---
_id: '11080'
abstract:
- lang: eng
text: The spindle assembly checkpoint prevents separation of sister chromatids until
each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report
that the nuclear pore complex scaffolds spindle assembly checkpoint signaling
in interphase, providing a store of inhibitory signals that limits the speed of
the subsequent mitosis.
article_processing_charge: No
article_type: original
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Buchwalter A, Hetzer M. Nuclear pores set the speed limit for mitosis. Cell.
2014;156(5):868-869. doi:10.1016/j.cell.2014.02.004
apa: Buchwalter, A., & Hetzer, M. (2014). Nuclear pores set the speed limit
for mitosis. Cell. Elsevier. https://doi.org/10.1016/j.cell.2014.02.004
chicago: Buchwalter, Abigail, and Martin Hetzer. “Nuclear Pores Set the Speed Limit
for Mitosis.” Cell. Elsevier, 2014. https://doi.org/10.1016/j.cell.2014.02.004.
ieee: A. Buchwalter and M. Hetzer, “Nuclear pores set the speed limit for mitosis,”
Cell, vol. 156, no. 5. Elsevier, pp. 868–869, 2014.
ista: Buchwalter A, Hetzer M. 2014. Nuclear pores set the speed limit for mitosis.
Cell. 156(5), 868–869.
mla: Buchwalter, Abigail, and Martin Hetzer. “Nuclear Pores Set the Speed Limit
for Mitosis.” Cell, vol. 156, no. 5, Elsevier, 2014, pp. 868–69, doi:10.1016/j.cell.2014.02.004.
short: A. Buchwalter, M. Hetzer, Cell 156 (2014) 868–869.
date_created: 2022-04-07T07:50:04Z
date_published: 2014-02-27T00:00:00Z
date_updated: 2022-07-18T08:44:33Z
day: '27'
doi: 10.1016/j.cell.2014.02.004
extern: '1'
external_id:
pmid:
- '24581486'
intvolume: ' 156'
issue: '5'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2014.02.004
month: '02'
oa: 1
oa_version: Published Version
page: 868-869
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nuclear pores set the speed limit for mitosis
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 156
year: '2014'
...
---
_id: '11082'
abstract:
- lang: eng
text: The nuclear pore complex (NPC) plays a critical role in gene expression by
mediating import of transcription regulators into the nucleus and export of RNA
transcripts to the cytoplasm. Emerging evidence suggests that in addition to mediating
transport, a subset of nucleoporins (Nups) engage in transcriptional activation
and elongation at genomic loci that are not associated with NPCs. The underlying
mechanism and regulation of Nup mobility on and off nuclear pores remain unclear.
Here we show that Nup50 is a mobile Nup with a pronounced presence both at the
NPC and in the nucleoplasm that can move between these different localizations.
Strikingly, the dynamic behavior of Nup50 in both locations is dependent on active
transcription by RNA polymerase II and requires the N-terminal half of the protein,
which contains importin α– and Nup153-binding domains. However, Nup50 dynamics
are independent of importin α, Nup153, and Nup98, even though the latter two proteins
also exhibit transcription-dependent mobility. Of interest, depletion of Nup50
from C2C12 myoblasts does not affect cell proliferation but inhibits differentiation
into myotubes. Taken together, our results suggest a transport-independent role
for Nup50 in chromatin biology that occurs away from the NPC.
article_processing_charge: No
article_type: original
author:
- first_name: Abigail L.
full_name: Buchwalter, Abigail L.
last_name: Buchwalter
- first_name: Yun
full_name: Liang, Yun
last_name: Liang
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Buchwalter AL, Liang Y, Hetzer M. Nup50 is required for cell differentiation
and exhibits transcription-dependent dynamics. Molecular Biology of the Cell.
2014;25(16):2472-2484. doi:10.1091/mbc.e14-04-0865
apa: Buchwalter, A. L., Liang, Y., & Hetzer, M. (2014). Nup50 is required for
cell differentiation and exhibits transcription-dependent dynamics. Molecular
Biology of the Cell. American Society for Cell Biology. https://doi.org/10.1091/mbc.e14-04-0865
chicago: Buchwalter, Abigail L., Yun Liang, and Martin Hetzer. “Nup50 Is Required
for Cell Differentiation and Exhibits Transcription-Dependent Dynamics.” Molecular
Biology of the Cell. American Society for Cell Biology, 2014. https://doi.org/10.1091/mbc.e14-04-0865.
ieee: A. L. Buchwalter, Y. Liang, and M. Hetzer, “Nup50 is required for cell differentiation
and exhibits transcription-dependent dynamics,” Molecular Biology of the Cell,
vol. 25, no. 16. American Society for Cell Biology, pp. 2472–2484, 2014.
ista: Buchwalter AL, Liang Y, Hetzer M. 2014. Nup50 is required for cell differentiation
and exhibits transcription-dependent dynamics. Molecular Biology of the Cell.
25(16), 2472–2484.
mla: Buchwalter, Abigail L., et al. “Nup50 Is Required for Cell Differentiation
and Exhibits Transcription-Dependent Dynamics.” Molecular Biology of the Cell,
vol. 25, no. 16, American Society for Cell Biology, 2014, pp. 2472–84, doi:10.1091/mbc.e14-04-0865.
short: A.L. Buchwalter, Y. Liang, M. Hetzer, Molecular Biology of the Cell 25 (2014)
2472–2484.
date_created: 2022-04-07T07:50:24Z
date_published: 2014-08-15T00:00:00Z
date_updated: 2022-07-18T08:45:20Z
day: '15'
doi: 10.1091/mbc.e14-04-0865
extern: '1'
intvolume: ' 25'
issue: '16'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1091/mbc.e14-04-0865
month: '08'
oa: 1
oa_version: Published Version
page: 2472-2484
publication: Molecular Biology of the Cell
publication_identifier:
issn:
- 1059-1524
- 1939-4586
publication_status: published
publisher: American Society for Cell Biology
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nup50 is required for cell differentiation and exhibits transcription-dependent
dynamics
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 25
year: '2014'
...
---
_id: '11081'
abstract:
- lang: eng
text: In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope
(NE). In metazoans, the NE breaks down in mitosis and it has been assumed that
the physical barrier separating nucleoplasm and cytoplasm remains intact during
the rest of the cell cycle and cell differentiation. However, recent studies suggest
that nonmitotic NE remodeling plays a critical role in development, virus infection,
laminopathies, and cancer. Although the mechanisms underlying these NE restructuring
events are currently being defined, one common theme is activation of protein
kinase C family members in the interphase nucleus to disrupt the nuclear lamina,
demonstrating the importance of the lamina in maintaining nuclear integrity.
article_processing_charge: No
article_type: review
author:
- first_name: Emily
full_name: Hatch, Emily
last_name: Hatch
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease.
Journal of Cell Biology. 2014;205(2):133-141. doi:10.1083/jcb.201402003
apa: Hatch, E., & Hetzer, M. (2014). Breaching the nuclear envelope in development
and disease. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201402003
chicago: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
and Disease.” Journal of Cell Biology. Rockefeller University Press, 2014.
https://doi.org/10.1083/jcb.201402003.
ieee: E. Hatch and M. Hetzer, “Breaching the nuclear envelope in development and
disease,” Journal of Cell Biology, vol. 205, no. 2. Rockefeller University
Press, pp. 133–141, 2014.
ista: Hatch E, Hetzer M. 2014. Breaching the nuclear envelope in development and
disease. Journal of Cell Biology. 205(2), 133–141.
mla: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
and Disease.” Journal of Cell Biology, vol. 205, no. 2, Rockefeller University
Press, 2014, pp. 133–41, doi:10.1083/jcb.201402003.
short: E. Hatch, M. Hetzer, Journal of Cell Biology 205 (2014) 133–141.
date_created: 2022-04-07T07:50:13Z
date_published: 2014-04-21T00:00:00Z
date_updated: 2022-07-18T08:45:09Z
day: '21'
doi: 10.1083/jcb.201402003
extern: '1'
external_id:
pmid:
- '24751535'
intvolume: ' 205'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1083/jcb.201402003
month: '04'
oa: 1
oa_version: Published Version
page: 133-141
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 1540-8140
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaching the nuclear envelope in development and disease
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 205
year: '2014'
...
---
_id: '11583'
abstract:
- lang: eng
text: 'Candidate galaxies at redshifts of z ∼ 10 are now being found in extremely
deep surveys, probing very small areas. As a consequence, candidates are very
faint, making spectroscopic confirmation practically impossible. In order to overcome
such limitations, we have undertaken the CF-HiZELS survey, which is a large-area,
medium-depth near-infrared narrow-band survey targeted at z = 8.8 Lyman α (Lyα)
emitters (LAEs) and covering 10 deg2 in part of the SSA22 field with the Canada–France–Hawaii
Telescope (CFHT). We surveyed a comoving volume of 4.7 × 106 Mpc3 to a Lyα luminosity
limit of 6.3 × 1043舁erg舁s−1. We look for Lyα candidates by applying the following
criteria: (i) clear emission-line source, (ii) no optical detections (ugriz from
CFHTLS), (iii) no visible detection in the optical stack (ugriz > 27), (iv) visually
checked reliable NBJ and J detections and (v) J − K ≤ 0. We compute photometric
redshifts and remove a significant amount of dusty lower redshift line-emitters
at z ∼ 1.4 or 2.2. A total of 13 Lyα candidates were found, of which two are marked
as strong candidates, but the majority have very weak constraints on their spectral
energy distributions. Using follow-up observations with SINFONI/VLT, we are able
to exclude the most robust candidates as LAEs. We put a strong constraint on the
Lyα luminosity function at z ∼ 9 and make realistic predictions for ongoing and
future surveys. Our results show that surveys for the highest redshift LAEs are
susceptible of multiple contaminations and that spectroscopic follow-up is absolutely
necessary.'
acknowledgement: We thank the anonymous referee for the comments and suggestions which
improved both the quality and clarity of this work. DS acknowledges financial support
from the Netherlands Organisation for Scientific Research (NWO) through a Veni fellowship.
IRS acknowledges support from STFC (ST/I001573/1), a Leverhulme Fellowship, the
ERC Advanced Investigator programme DUSTYGAL 321334 and a Royal Society/Wolfson
Merit Award. PNB acknowledges support from the Leverhulme Trust. JWK acknowledges
the support from the Creative Research Initiative Program, no. 2008- 0060544, of
the National Research Foundation of Korea (NRF) funded by the Korean government
(MSIP). JPUF and BMJ acknowledge support from the ERC-StG grant EGGS-278202. The
Dark Cosmology Centre is funded by the Danish National Research Foundation. This
work is based in part on data obtained as part of the UKIRT Infrared Deep Sky Survey.
Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and
CEA/IRFU, at the Canada–France–Hawaii Telescope (CFHT) which is operated by the
National Research Council (NRC) of Canada, the Institut National des Science de
l’Univers of the Centre National de la Recherche Scientifique (CNRS) of France and
the University of Hawaii. This work is based in part on data products produced at
Terapix available at the Canadian Astronomy Data Centre as part of the Canada-France-Hawaii
Telescope Legacy Survey, a collaborative project of NRC and CNRS. This work was
only possible due to OPTICON/FP7 and the access that it granted to the CFHT telescope.
The authors also wish to acknowledge the CFHTLS and UKIDSS surveys for their excellent
legacy and complementary value – without such high-quality data sets, this research
would not have been possible.
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: A. M.
full_name: Swinbank, A. M.
last_name: Swinbank
- first_name: Ian
full_name: Smail, Ian
last_name: Smail
- first_name: P. N.
full_name: Best, P. N.
last_name: Best
- first_name: Jae-Woo
full_name: Kim, Jae-Woo
last_name: Kim
- first_name: Marijn
full_name: Franx, Marijn
last_name: Franx
- first_name: Bo
full_name: Milvang-Jensen, Bo
last_name: Milvang-Jensen
- first_name: Johan
full_name: Fynbo, Johan
last_name: Fynbo
citation:
ama: 'Matthee JJ, Sobral D, Swinbank AM, et al. A 10 deg2 Lyman α survey at z=8.8
with spectroscopic follow-up: Strong constraints on the luminosity function and
implications for other surveys. Monthly Notices of the Royal Astronomical Society.
2014;440(3):2375-2387. doi:10.1093/mnras/stu392'
apa: 'Matthee, J. J., Sobral, D., Swinbank, A. M., Smail, I., Best, P. N., Kim,
J.-W., … Fynbo, J. (2014). A 10 deg2 Lyman α survey at z=8.8 with spectroscopic
follow-up: Strong constraints on the luminosity function and implications for
other surveys. Monthly Notices of the Royal Astronomical Society. Oxford
University Press. https://doi.org/10.1093/mnras/stu392'
chicago: 'Matthee, Jorryt J, David Sobral, A. M. Swinbank, Ian Smail, P. N. Best,
Jae-Woo Kim, Marijn Franx, Bo Milvang-Jensen, and Johan Fynbo. “A 10 Deg2 Lyman
α Survey at Z=8.8 with Spectroscopic Follow-up: Strong Constraints on the Luminosity
Function and Implications for Other Surveys.” Monthly Notices of the Royal
Astronomical Society. Oxford University Press, 2014. https://doi.org/10.1093/mnras/stu392.'
ieee: 'J. J. Matthee et al., “A 10 deg2 Lyman α survey at z=8.8 with spectroscopic
follow-up: Strong constraints on the luminosity function and implications for
other surveys,” Monthly Notices of the Royal Astronomical Society, vol.
440, no. 3. Oxford University Press, pp. 2375–2387, 2014.'
ista: 'Matthee JJ, Sobral D, Swinbank AM, Smail I, Best PN, Kim J-W, Franx M, Milvang-Jensen
B, Fynbo J. 2014. A 10 deg2 Lyman α survey at z=8.8 with spectroscopic follow-up:
Strong constraints on the luminosity function and implications for other surveys.
Monthly Notices of the Royal Astronomical Society. 440(3), 2375–2387.'
mla: 'Matthee, Jorryt J., et al. “A 10 Deg2 Lyman α Survey at Z=8.8 with Spectroscopic
Follow-up: Strong Constraints on the Luminosity Function and Implications for
Other Surveys.” Monthly Notices of the Royal Astronomical Society, vol.
440, no. 3, Oxford University Press, 2014, pp. 2375–87, doi:10.1093/mnras/stu392.'
short: J.J. Matthee, D. Sobral, A.M. Swinbank, I. Smail, P.N. Best, J.-W. Kim, M.
Franx, B. Milvang-Jensen, J. Fynbo, Monthly Notices of the Royal Astronomical
Society 440 (2014) 2375–2387.
date_created: 2022-07-14T12:33:24Z
date_published: 2014-05-21T00:00:00Z
date_updated: 2022-08-19T08:30:30Z
day: '21'
doi: 10.1093/mnras/stu392
extern: '1'
external_id:
arxiv:
- '1402.6697'
intvolume: ' 440'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'cosmology: observations'
- dark ages
- reionization
- first stars
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1402.6697
month: '05'
oa: 1
oa_version: Preprint
page: 2375-2387
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A 10 deg2 Lyman α survey at z=8.8 with spectroscopic follow-up: Strong constraints
on the luminosity function and implications for other surveys'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 440
year: '2014'
...
---
_id: '11582'
abstract:
- lang: eng
text: We have observed a sample of typical z ∼ 1 star-forming galaxies, selected
from the HiZELS survey, with the new K-band Multi-Object Spectrograph (KMOS) near-infrared,
multi-integral field unit instrument on the Very Large Telescope (VLT), in order
to obtain their dynamics and metallicity gradients. The majority of our galaxies
have a metallicity gradient consistent with being flat or negative (i.e. higher
metallicity cores than outskirts). Intriguingly, we find a trend between metallicity
gradient and specific star formation rate (sSFR), such that galaxies with a high
sSFR tend to have relatively metal poor centres, a result which is strengthened
when combined with data sets from the literature. This result appears to explain
the discrepancies reported between different high-redshift studies and varying
claims for evolution. From a galaxy evolution perspective, the trend we see would
mean that a galaxy's sSFR is governed by the amount of metal-poor gas that can
be funnelled into its core, triggered either by merging or through efficient accretion.
In fact, merging may play a significant role as it is the starburst galaxies at
all epochs, which have the more positive metallicity gradients. Our results may
help to explain the origin of the fundamental metallicity relation, in which galaxies
at a fixed mass are observed to have lower metallicities at higher star formation
rates, especially if the metallicity is measured in an aperture encompassing only
the central regions of the galaxy. Finally, we note that this study demonstrates
the power of KMOS as an efficient instrument for large-scale resolved galaxy surveys.
acknowledgement: First, we acknowledge the referee for their comments, which have
improved the clarity of this paper. JPS and IRS acknowledge support from STFC (ST/I001573/1).
IRS also acknowledges support from the ERC Advanced Investigator programme DUSTYGAL
and a Royal Society/Wolfson Merit Award. DS acknowledges financial support from
NWO through a Veni fellowship and from FCT through the award of an FCT-IF starting
grant. PNB acknowledges STFC for financial support.
article_processing_charge: No
article_type: original
author:
- first_name: John P.
full_name: Stott, John P.
last_name: Stott
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: A. M.
full_name: Swinbank, A. M.
last_name: Swinbank
- first_name: Ian
full_name: Smail, Ian
last_name: Smail
- first_name: Richard
full_name: Bower, Richard
last_name: Bower
- first_name: Philip N.
full_name: Best, Philip N.
last_name: Best
- first_name: Ray M.
full_name: Sharples, Ray M.
last_name: Sharples
- first_name: James E.
full_name: Geach, James E.
last_name: Geach
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: Stott JP, Sobral D, Swinbank AM, et al. A relationship between specific star
formation rate and metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS.
Monthly Notices of the Royal Astronomical Society. 2014;443(3):2695-2704.
doi:10.1093/mnras/stu1343
apa: Stott, J. P., Sobral, D., Swinbank, A. M., Smail, I., Bower, R., Best, P. N.,
… Matthee, J. J. (2014). A relationship between specific star formation rate and
metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS. Monthly Notices
of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stu1343
chicago: Stott, John P., David Sobral, A. M. Swinbank, Ian Smail, Richard Bower,
Philip N. Best, Ray M. Sharples, James E. Geach, and Jorryt J Matthee. “A Relationship
between Specific Star Formation Rate and Metallicity Gradient within z ∼ 1 Galaxies
from KMOS-HiZELS.” Monthly Notices of the Royal Astronomical Society. Oxford
University Press, 2014. https://doi.org/10.1093/mnras/stu1343.
ieee: J. P. Stott et al., “A relationship between specific star formation
rate and metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS,” Monthly
Notices of the Royal Astronomical Society, vol. 443, no. 3. Oxford University
Press, pp. 2695–2704, 2014.
ista: Stott JP, Sobral D, Swinbank AM, Smail I, Bower R, Best PN, Sharples RM, Geach
JE, Matthee JJ. 2014. A relationship between specific star formation rate and
metallicity gradient within z ∼ 1 galaxies from KMOS-HiZELS. Monthly Notices of
the Royal Astronomical Society. 443(3), 2695–2704.
mla: Stott, John P., et al. “A Relationship between Specific Star Formation Rate
and Metallicity Gradient within z ∼ 1 Galaxies from KMOS-HiZELS.” Monthly Notices
of the Royal Astronomical Society, vol. 443, no. 3, Oxford University Press,
2014, pp. 2695–704, doi:10.1093/mnras/stu1343.
short: J.P. Stott, D. Sobral, A.M. Swinbank, I. Smail, R. Bower, P.N. Best, R.M.
Sharples, J.E. Geach, J.J. Matthee, Monthly Notices of the Royal Astronomical
Society 443 (2014) 2695–2704.
date_created: 2022-07-14T12:16:10Z
date_published: 2014-09-21T00:00:00Z
date_updated: 2022-08-19T08:27:25Z
day: '21'
doi: 10.1093/mnras/stu1343
extern: '1'
external_id:
arxiv:
- '1407.1047'
intvolume: ' 443'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: abundances'
- 'galaxies: evolution'
- 'galaxies: kinematics and dynamics'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1407.1047
month: '09'
oa: 1
oa_version: Preprint
page: 2695-2704
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A relationship between specific star formation rate and metallicity gradient
within z ∼ 1 galaxies from KMOS-HiZELS
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 443
year: '2014'
...