---
_id: '7552'
abstract:
- lang: eng
text: 'There is increasing evidence that protein binding to specific sites along
DNA can activate the reading out of genetic information without coming into direct
physical contact with the gene. There also is evidence that these distant but
interacting sites are embedded in a liquid droplet of proteins which condenses
out of the surrounding solution. We argue that droplet-mediated interactions can
account for crucial features of gene regulation only if the droplet is poised
at a non-generic point in its phase diagram. We explore a minimal model that embodies
this idea, show that this model has a natural mechanism for self-tuning, and suggest
direct experimental tests. '
article_processing_charge: No
author:
- first_name: William
full_name: Bialek, William
last_name: Bialek
- first_name: Thomas
full_name: Gregor, Thomas
last_name: Gregor
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Bialek W, Gregor T, Tkačik G. Action at a distance in transcriptional regulation.
arXiv:191208579.
apa: Bialek, W., Gregor, T., & Tkačik, G. (n.d.). Action at a distance in transcriptional
regulation. arXiv:1912.08579. ArXiv.
chicago: Bialek, William, Thomas Gregor, and Gašper Tkačik. “Action at a Distance
in Transcriptional Regulation.” ArXiv:1912.08579. ArXiv, n.d.
ieee: W. Bialek, T. Gregor, and G. Tkačik, “Action at a distance in transcriptional
regulation,” arXiv:1912.08579. ArXiv.
ista: Bialek W, Gregor T, Tkačik G. Action at a distance in transcriptional regulation.
arXiv:1912.08579, .
mla: Bialek, William, et al. “Action at a Distance in Transcriptional Regulation.”
ArXiv:1912.08579, ArXiv.
short: W. Bialek, T. Gregor, G. Tkačik, ArXiv:1912.08579 (n.d.).
date_created: 2020-02-28T10:57:08Z
date_published: 2019-12-18T00:00:00Z
date_updated: 2021-01-12T08:14:09Z
day: '18'
department:
- _id: GaTk
external_id:
arxiv:
- '1912.08579'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.08579
month: '12'
oa: 1
oa_version: Preprint
page: '5'
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: arXiv:1912.08579
publication_status: submitted
publisher: ArXiv
status: public
title: Action at a distance in transcriptional regulation
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '7576'
abstract:
- lang: eng
text: We present the results of a friendly competition for formal verification of
continuous and hybrid systems with nonlinear continuous dynamics. The friendly
competition took place as part of the workshop Applied Verification for Continuous
and Hybrid Systems (ARCH) in 2019. In this year, 6 tools Ariadne, CORA, DynIbex,
Flow*, Isabelle/HOL, and JuliaReach (in alphabetic order) participated. They are
applied to solve reachability analysis problems on four benchmark problems, one
of them with hybrid dynamics. We do not rank the tools based on the results, but
show the current status and discover the potential advantages of different tools.
article_processing_charge: No
author:
- first_name: Fabian
full_name: Immler, Fabian
last_name: Immler
- first_name: Matthias
full_name: Althoff, Matthias
last_name: Althoff
- first_name: Luis
full_name: Benet, Luis
last_name: Benet
- first_name: Alexandre
full_name: Chapoutot, Alexandre
last_name: Chapoutot
- first_name: Xin
full_name: Chen, Xin
last_name: Chen
- first_name: Marcelo
full_name: Forets, Marcelo
last_name: Forets
- first_name: Luca
full_name: Geretti, Luca
last_name: Geretti
- first_name: Niklas
full_name: Kochdumper, Niklas
last_name: Kochdumper
- first_name: David P.
full_name: Sanders, David P.
last_name: Sanders
- first_name: Christian
full_name: Schilling, Christian
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
citation:
ama: 'Immler F, Althoff M, Benet L, et al. ARCH-COMP19 Category Report: Continuous
and hybrid systems with nonlinear dynamics. In: EPiC Series in Computing.
Vol 61. EasyChair Publications; 2019:41-61. doi:10.29007/m75b'
apa: 'Immler, F., Althoff, M., Benet, L., Chapoutot, A., Chen, X., Forets, M., …
Schilling, C. (2019). ARCH-COMP19 Category Report: Continuous and hybrid systems
with nonlinear dynamics. In EPiC Series in Computing (Vol. 61, pp. 41–61).
Montreal, Canada: EasyChair Publications. https://doi.org/10.29007/m75b'
chicago: 'Immler, Fabian, Matthias Althoff, Luis Benet, Alexandre Chapoutot, Xin
Chen, Marcelo Forets, Luca Geretti, Niklas Kochdumper, David P. Sanders, and Christian
Schilling. “ARCH-COMP19 Category Report: Continuous and Hybrid Systems with Nonlinear
Dynamics.” In EPiC Series in Computing, 61:41–61. EasyChair Publications,
2019. https://doi.org/10.29007/m75b.'
ieee: 'F. Immler et al., “ARCH-COMP19 Category Report: Continuous and hybrid
systems with nonlinear dynamics,” in EPiC Series in Computing, Montreal,
Canada, 2019, vol. 61, pp. 41–61.'
ista: 'Immler F, Althoff M, Benet L, Chapoutot A, Chen X, Forets M, Geretti L, Kochdumper
N, Sanders DP, Schilling C. 2019. ARCH-COMP19 Category Report: Continuous and
hybrid systems with nonlinear dynamics. EPiC Series in Computing. ARCH: International
Workshop on Applied Verification on Continuous and Hybrid Systems vol. 61, 41–61.'
mla: 'Immler, Fabian, et al. “ARCH-COMP19 Category Report: Continuous and Hybrid
Systems with Nonlinear Dynamics.” EPiC Series in Computing, vol. 61, EasyChair
Publications, 2019, pp. 41–61, doi:10.29007/m75b.'
short: F. Immler, M. Althoff, L. Benet, A. Chapoutot, X. Chen, M. Forets, L. Geretti,
N. Kochdumper, D.P. Sanders, C. Schilling, in:, EPiC Series in Computing, EasyChair
Publications, 2019, pp. 41–61.
conference:
end_date: 2019-04-15
location: Montreal, Canada
name: 'ARCH: International Workshop on Applied Verification on Continuous and Hybrid
Systems'
start_date: 2019-04-15
date_created: 2020-03-08T23:00:49Z
date_published: 2019-05-25T00:00:00Z
date_updated: 2021-01-12T08:14:17Z
day: '25'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.29007/m75b
file:
- access_level: open_access
checksum: 9138977a06fcd6a95976eb4bca875f0c
content_type: application/pdf
creator: dernst
date_created: 2020-03-24T07:36:36Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7617'
file_name: 2019_ARCH19_Immler.pdf
file_size: 1934830
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
has_accepted_license: '1'
intvolume: ' 61'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 41-61
publication: EPiC Series in Computing
publication_identifier:
eissn:
- '23987340'
publication_status: published
publisher: EasyChair Publications
quality_controlled: '1'
scopus_import: 1
status: public
title: 'ARCH-COMP19 Category Report: Continuous and hybrid systems with nonlinear
dynamics'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2019'
...
---
_id: '7627'
abstract:
- lang: eng
text: 'Electrodepositing insulating and insoluble Li2O2 is the key process during discharge of aprotic Li-O2
batteries and determines rate, capacity, and reversibility. Current understanding states that the
partition between surface adsorbed and solvated LiO2 governs whether Li2O2 grows as surface film,
leading to low capacity even at low rates, or in solution, leading to particles
and high capacities. Here we show that Li2O2 forms to the widest extent as particles
via solution mediated LiO2 disproportionation. We describe a unified Li2O2 growth model that conclusively explains capacity limitations across the
whole range of electrolytes. Deciding for particle morphology, achievable rate
and capacities are species mobilities, electrode specific surface area (determining true areal rate) and the concentration
distribution of associated LiO2 in solution. Provided that species mobilities
and surface are high, high, capacities are possible even with low-donor-number
electrolytes, previously considered prototypical for low capacity via surface growth. The tools for these insights are microscopy, hydrodynamic
voltammetry, a numerical reaction model, and in situ small/wide angle X-ray scattering
(SAXS/WAXS). Combined with sophisticated data analysis, SAXS allows retrieving
rich quantitative information from complex multi-phase systems. On a wider perspective,
this SAXS method is a powerful in situ metrology with atomic to sub-micron resolution to study mechanisms in complex electrochemical systems and
beyond. '
article_processing_charge: No
author:
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Aleksej
full_name: Samojlov, Aleksej
last_name: Samojlov
- first_name: Manfred
full_name: Nachtnebel, Manfred
last_name: Nachtnebel
- first_name: Manfred
full_name: Kriechbaum, Manfred
last_name: Kriechbaum
- first_name: Heinz
full_name: Amenitsch, Heinz
last_name: Amenitsch
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Prehal C, Samojlov A, Nachtnebel M, Kriechbaum M, Amenitsch H, Freunberger
SA. A revised O2 reduction model in Li-O2 batteries as revealed by in situ small
angle X-ray scattering.
apa: Prehal, C., Samojlov, A., Nachtnebel, M., Kriechbaum, M., Amenitsch, H., &
Freunberger, S. A. (n.d.). A revised O2 reduction model in Li-O2 batteries as
revealed by in situ small angle X-ray scattering. ChemRxiv.
chicago: Prehal, Christian, Aleksej Samojlov, Manfred Nachtnebel, Manfred Kriechbaum,
Heinz Amenitsch, and Stefan Alexander Freunberger. “A Revised O2 Reduction Model
in Li-O2 Batteries as Revealed by in Situ Small Angle X-Ray Scattering.” ChemRxiv,
n.d.
ieee: C. Prehal, A. Samojlov, M. Nachtnebel, M. Kriechbaum, H. Amenitsch, and S.
A. Freunberger, “A revised O2 reduction model in Li-O2 batteries as revealed by
in situ small angle X-ray scattering.” ChemRxiv.
ista: Prehal C, Samojlov A, Nachtnebel M, Kriechbaum M, Amenitsch H, Freunberger
SA. A revised O2 reduction model in Li-O2 batteries as revealed by in situ small
angle X-ray scattering.
mla: Prehal, Christian, et al. A Revised O2 Reduction Model in Li-O2 Batteries
as Revealed by in Situ Small Angle X-Ray Scattering. ChemRxiv.
short: C. Prehal, A. Samojlov, M. Nachtnebel, M. Kriechbaum, H. Amenitsch, S.A.
Freunberger, (n.d.).
date_created: 2020-04-01T10:10:21Z
date_published: 2019-12-26T00:00:00Z
date_updated: 2020-04-06T10:36:21Z
day: '26'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.26434/chemrxiv.11447775.v1
month: '12'
oa: 1
oa_version: Preprint
page: '50'
publication_status: submitted
publisher: ChemRxiv
status: public
title: A revised O2 reduction model in Li-O2 batteries as revealed by in situ small
angle X-ray scattering
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '7710'
abstract:
- lang: eng
text: 'The number of human genomes being genotyped or sequenced increases exponentially
and efficient haplotype estimation methods able to handle this amount of data
are now required. Here we present a method, SHAPEIT4, which substantially improves
upon other methods to process large genotype and high coverage sequencing datasets.
It notably exhibits sub-linear running times with sample size, provides highly
accurate haplotypes and allows integrating external phasing information such as
large reference panels of haplotypes, collections of pre-phased variants and long
sequencing reads. We provide SHAPEIT4 in an open source format and demonstrate
its performance in terms of accuracy and running times on two gold standard datasets:
the UK Biobank data and the Genome In A Bottle.'
article_number: '5436'
article_processing_charge: No
article_type: original
author:
- first_name: Olivier
full_name: Delaneau, Olivier
last_name: Delaneau
- first_name: Jean-François
full_name: Zagury, Jean-François
last_name: Zagury
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Jonathan L.
full_name: Marchini, Jonathan L.
last_name: Marchini
- first_name: Emmanouil T.
full_name: Dermitzakis, Emmanouil T.
last_name: Dermitzakis
citation:
ama: Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. Accurate,
scalable and integrative haplotype estimation. Nature Communications. 2019;10.
doi:10.1038/s41467-019-13225-y
apa: Delaneau, O., Zagury, J.-F., Robinson, M. R., Marchini, J. L., & Dermitzakis,
E. T. (2019). Accurate, scalable and integrative haplotype estimation. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-019-13225-y
chicago: Delaneau, Olivier, Jean-François Zagury, Matthew Richard Robinson, Jonathan
L. Marchini, and Emmanouil T. Dermitzakis. “Accurate, Scalable and Integrative
Haplotype Estimation.” Nature Communications. Springer Nature, 2019. https://doi.org/10.1038/s41467-019-13225-y.
ieee: O. Delaneau, J.-F. Zagury, M. R. Robinson, J. L. Marchini, and E. T. Dermitzakis,
“Accurate, scalable and integrative haplotype estimation,” Nature Communications,
vol. 10. Springer Nature, 2019.
ista: Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. 2019. Accurate,
scalable and integrative haplotype estimation. Nature Communications. 10, 5436.
mla: Delaneau, Olivier, et al. “Accurate, Scalable and Integrative Haplotype Estimation.”
Nature Communications, vol. 10, 5436, Springer Nature, 2019, doi:10.1038/s41467-019-13225-y.
short: O. Delaneau, J.-F. Zagury, M.R. Robinson, J.L. Marchini, E.T. Dermitzakis,
Nature Communications 10 (2019).
date_created: 2020-04-30T10:40:32Z
date_published: 2019-11-28T00:00:00Z
date_updated: 2021-01-12T08:15:01Z
day: '28'
doi: 10.1038/s41467-019-13225-y
extern: '1'
intvolume: ' 10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-019-13225-y
month: '11'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Accurate, scalable and integrative haplotype estimation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2019'
...
---
_id: '7711'
abstract:
- lang: eng
text: The nature and extent of mitochondrial DNA variation in a population and how
it affects traits is poorly understood. Here we resequence the mitochondrial genomes
of 169 Drosophila Genetic Reference Panel lines, identifying 231 variants that
stratify along 12 mitochondrial haplotypes. We identify 1,845 cases of mitonuclear
allelic imbalances, thus implying that mitochondrial haplotypes are reflected
in the nuclear genome. However, no major fitness effects are associated with mitonuclear
imbalance, suggesting that such imbalances reflect population structure at the
mitochondrial level rather than genomic incompatibilities. Although mitochondrial
haplotypes have no direct impact on mitochondrial respiration, some haplotypes
are associated with stress- and metabolism-related phenotypes, including food
intake in males. Finally, through reciprocal swapping of mitochondrial genomes,
we demonstrate that a mitochondrial haplotype associated with high food intake
can rescue a low food intake phenotype. Together, our findings provide new insight
into population structure at the mitochondrial level and point to the importance
of incorporating mitochondrial haplotypes in genotype–phenotype relationship studies.
article_processing_charge: No
article_type: original
author:
- first_name: Roel P. J.
full_name: Bevers, Roel P. J.
last_name: Bevers
- first_name: Maria
full_name: Litovchenko, Maria
last_name: Litovchenko
- first_name: Adamandia
full_name: Kapopoulou, Adamandia
last_name: Kapopoulou
- first_name: Virginie S.
full_name: Braman, Virginie S.
last_name: Braman
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Johan
full_name: Auwerx, Johan
last_name: Auwerx
- first_name: Brian
full_name: Hollis, Brian
last_name: Hollis
- first_name: Bart
full_name: Deplancke, Bart
last_name: Deplancke
citation:
ama: Bevers RPJ, Litovchenko M, Kapopoulou A, et al. Mitochondrial haplotypes affect
metabolic phenotypes in the Drosophila Genetic Reference Panel. Nature Metabolism.
2019;1(12):1226-1242. doi:10.1038/s42255-019-0147-3
apa: Bevers, R. P. J., Litovchenko, M., Kapopoulou, A., Braman, V. S., Robinson,
M. R., Auwerx, J., … Deplancke, B. (2019). Mitochondrial haplotypes affect metabolic
phenotypes in the Drosophila Genetic Reference Panel. Nature Metabolism.
Springer Nature. https://doi.org/10.1038/s42255-019-0147-3
chicago: Bevers, Roel P. J., Maria Litovchenko, Adamandia Kapopoulou, Virginie S.
Braman, Matthew Richard Robinson, Johan Auwerx, Brian Hollis, and Bart Deplancke.
“Mitochondrial Haplotypes Affect Metabolic Phenotypes in the Drosophila Genetic
Reference Panel.” Nature Metabolism. Springer Nature, 2019. https://doi.org/10.1038/s42255-019-0147-3.
ieee: R. P. J. Bevers et al., “Mitochondrial haplotypes affect metabolic
phenotypes in the Drosophila Genetic Reference Panel,” Nature Metabolism,
vol. 1, no. 12. Springer Nature, pp. 1226–1242, 2019.
ista: Bevers RPJ, Litovchenko M, Kapopoulou A, Braman VS, Robinson MR, Auwerx J,
Hollis B, Deplancke B. 2019. Mitochondrial haplotypes affect metabolic phenotypes
in the Drosophila Genetic Reference Panel. Nature Metabolism. 1(12), 1226–1242.
mla: Bevers, Roel P. J., et al. “Mitochondrial Haplotypes Affect Metabolic Phenotypes
in the Drosophila Genetic Reference Panel.” Nature Metabolism, vol. 1,
no. 12, Springer Nature, 2019, pp. 1226–42, doi:10.1038/s42255-019-0147-3.
short: R.P.J. Bevers, M. Litovchenko, A. Kapopoulou, V.S. Braman, M.R. Robinson,
J. Auwerx, B. Hollis, B. Deplancke, Nature Metabolism 1 (2019) 1226–1242.
date_created: 2020-04-30T10:40:56Z
date_published: 2019-12-09T00:00:00Z
date_updated: 2021-01-12T08:15:01Z
day: '09'
doi: 10.1038/s42255-019-0147-3
extern: '1'
intvolume: ' 1'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1226-1242
publication: Nature Metabolism
publication_identifier:
issn:
- 2522-5812
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s42255-020-0202-0
status: public
title: Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic
Reference Panel
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2019'
...