---
_id: '7619'
abstract:
- lang: eng
text: Cell polarity is a fundamental feature of all multicellular organisms. In
plants, prominent cell polarity markers are PIN auxin transporters crucial for
plant development. To identify novel components involved in cell polarity establishment
and maintenance, we carried out a forward genetic screening with PIN2:PIN1-HA;pin2
Arabidopsis plants, which ectopically express predominantly basally localized
PIN1 in the root epidermal cells leading to agravitropic root growth. From the
screen, we identified the regulator of PIN polarity 12 (repp12) mutation, which
restored gravitropic root growth and caused PIN1-HA polarity switch from basal
to apical side of root epidermal cells. Complementation experiments established
the repp12 causative mutation as an amino acid substitution in Aminophospholipid
ATPase3 (ALA3), a phospholipid flippase with predicted function in vesicle formation.
ala3 T-DNA mutants show defects in many auxin-regulated processes, in asymmetric
auxin distribution and in PIN trafficking. Analysis of quintuple and sextuple
mutants confirmed a crucial role of ALA proteins in regulating plant development
and in PIN trafficking and polarity. Genetic and physical interaction studies
revealed that ALA3 functions together with GNOM and BIG3 ARF GEFs. Taken together,
our results identified ALA3 flippase as an important interactor and regulator
of ARF GEF functioning in PIN polarity, trafficking and auxin-mediated development.
acknowledged_ssus:
- _id: Bio
article_processing_charge: No
article_type: original
author:
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Maciek
full_name: Adamowski, Maciek
id: 45F536D2-F248-11E8-B48F-1D18A9856A87
last_name: Adamowski
orcid: 0000-0001-6463-5257
- first_name: Petra
full_name: Marhavá, Petra
id: 44E59624-F248-11E8-B48F-1D18A9856A87
last_name: Marhavá
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Marta
full_name: Zwiewka, Marta
last_name: Zwiewka
- first_name: Vendula
full_name: Pukyšová, Vendula
last_name: Pukyšová
- first_name: Adrià Sans
full_name: Sánchez, Adrià Sans
last_name: Sánchez
- first_name: Vivek Kumar
full_name: Raxwal, Vivek Kumar
last_name: Raxwal
- first_name: Christian S.
full_name: Hardtke, Christian S.
last_name: Hardtke
- first_name: Tomasz
full_name: Nodzynski, Tomasz
last_name: Nodzynski
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Zhang X, Adamowski M, Marhavá P, et al. Arabidopsis flippases cooperate with
ARF GTPase exchange factors to regulate the trafficking and polarity of PIN auxin
transporters. The Plant Cell. 2020;32(5):1644-1664. doi:10.1105/tpc.19.00869
apa: Zhang, X., Adamowski, M., Marhavá, P., Tan, S., Zhang, Y., Rodriguez Solovey,
L., … Friml, J. (2020). Arabidopsis flippases cooperate with ARF GTPase exchange
factors to regulate the trafficking and polarity of PIN auxin transporters. The
Plant Cell. American Society of Plant Biologists. https://doi.org/10.1105/tpc.19.00869
chicago: Zhang, Xixi, Maciek Adamowski, Petra Marhavá, Shutang Tan, Yuzhou Zhang,
Lesia Rodriguez Solovey, Marta Zwiewka, et al. “Arabidopsis Flippases Cooperate
with ARF GTPase Exchange Factors to Regulate the Trafficking and Polarity of PIN
Auxin Transporters.” The Plant Cell. American Society of Plant Biologists,
2020. https://doi.org/10.1105/tpc.19.00869.
ieee: X. Zhang et al., “Arabidopsis flippases cooperate with ARF GTPase exchange
factors to regulate the trafficking and polarity of PIN auxin transporters,” The
Plant Cell, vol. 32, no. 5. American Society of Plant Biologists, pp. 1644–1664,
2020.
ista: Zhang X, Adamowski M, Marhavá P, Tan S, Zhang Y, Rodriguez Solovey L, Zwiewka
M, Pukyšová V, Sánchez AS, Raxwal VK, Hardtke CS, Nodzynski T, Friml J. 2020.
Arabidopsis flippases cooperate with ARF GTPase exchange factors to regulate the
trafficking and polarity of PIN auxin transporters. The Plant Cell. 32(5), 1644–1664.
mla: Zhang, Xixi, et al. “Arabidopsis Flippases Cooperate with ARF GTPase Exchange
Factors to Regulate the Trafficking and Polarity of PIN Auxin Transporters.” The
Plant Cell, vol. 32, no. 5, American Society of Plant Biologists, 2020, pp.
1644–64, doi:10.1105/tpc.19.00869.
short: X. Zhang, M. Adamowski, P. Marhavá, S. Tan, Y. Zhang, L. Rodriguez Solovey,
M. Zwiewka, V. Pukyšová, A.S. Sánchez, V.K. Raxwal, C.S. Hardtke, T. Nodzynski,
J. Friml, The Plant Cell 32 (2020) 1644–1664.
date_created: 2020-03-28T07:39:22Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-09-05T12:21:06Z
day: '01'
department:
- _id: JiFr
doi: 10.1105/tpc.19.00869
ec_funded: 1
external_id:
isi:
- '000545741500030'
pmid:
- '32193204'
intvolume: ' 32'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1105/tpc.19.00869
month: '05'
oa: 1
oa_version: Published Version
page: 1644-1664
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: The Plant Cell
publication_identifier:
eissn:
- 1532-298X
issn:
- 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arabidopsis flippases cooperate with ARF GTPase exchange factors to regulate
the trafficking and polarity of PIN auxin transporters
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2020'
...
---
_id: '8607'
abstract:
- lang: eng
text: Clathrin-mediated endocytosis (CME) and its core endocytic machinery are evolutionarily
conserved across all eukaryotes. In mammals, the heterotetrameric adaptor protein
complex-2 (AP-2) sorts plasma membrane (PM) cargoes into vesicles through the
recognition of motifs based on tyrosine or di-leucine in their cytoplasmic tails.
However, in plants, very little is known on how PM proteins are sorted for CME
and whether similar motifs are required. In Arabidopsis thaliana, the brassinosteroid
(BR) receptor, BR INSENSITIVE1 (BRI1), undergoes endocytosis that depends on clathrin
and AP-2. Here we demonstrate that BRI1 binds directly to the medium AP-2 subunit,
AP2M. The cytoplasmic domain of BRI1 contains five putative canonical surface-exposed
tyrosine-based endocytic motifs. The tyrosine-to-phenylalanine substitution in
Y898KAI reduced BRI1 internalization without affecting its kinase activity. Consistently,
plants carrying the BRI1Y898F mutation were hypersensitive to BRs. Our study demonstrates
that AP-2-dependent internalization of PM proteins via the recognition of functional
tyrosine motifs also operates in plants.
article_processing_charge: No
article_type: original
author:
- first_name: D
full_name: Liu, D
last_name: Liu
- first_name: R
full_name: Kumar, R
last_name: Kumar
- first_name: Claus
full_name: LAN, Claus
last_name: LAN
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: W
full_name: Siao, W
last_name: Siao
- first_name: I
full_name: Vanhoutte, I
last_name: Vanhoutte
- first_name: P
full_name: Wang, P
last_name: Wang
- first_name: KW
full_name: Bender, KW
last_name: Bender
- first_name: K
full_name: Yperman, K
last_name: Yperman
- first_name: S
full_name: Martins, S
last_name: Martins
- first_name: X
full_name: Zhao, X
last_name: Zhao
- first_name: G
full_name: Vert, G
last_name: Vert
- first_name: D
full_name: Van Damme, D
last_name: Van Damme
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: E
full_name: Russinova, E
last_name: Russinova
citation:
ama: Liu D, Kumar R, LAN C, et al. Endocytosis of BRASSINOSTEROID INSENSITIVE1 is
partly driven by a canonical tyrosine-based Motif. Plant Cell. 2020;32(11):3598-3612.
doi:10.1105/tpc.20.00384
apa: Liu, D., Kumar, R., LAN, C., Johnson, A. J., Siao, W., Vanhoutte, I., … Russinova,
E. (2020). Endocytosis of BRASSINOSTEROID INSENSITIVE1 is partly driven by a canonical
tyrosine-based Motif. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.20.00384
chicago: Liu, D, R Kumar, Claus LAN, Alexander J Johnson, W Siao, I Vanhoutte, P
Wang, et al. “Endocytosis of BRASSINOSTEROID INSENSITIVE1 Is Partly Driven by
a Canonical Tyrosine-Based Motif.” Plant Cell. American Society of Plant
Biologists, 2020. https://doi.org/10.1105/tpc.20.00384.
ieee: D. Liu et al., “Endocytosis of BRASSINOSTEROID INSENSITIVE1 is partly
driven by a canonical tyrosine-based Motif,” Plant Cell, vol. 32, no. 11.
American Society of Plant Biologists, pp. 3598–3612, 2020.
ista: Liu D, Kumar R, LAN C, Johnson AJ, Siao W, Vanhoutte I, Wang P, Bender K,
Yperman K, Martins S, Zhao X, Vert G, Van Damme D, Friml J, Russinova E. 2020.
Endocytosis of BRASSINOSTEROID INSENSITIVE1 is partly driven by a canonical tyrosine-based
Motif. Plant Cell. 32(11), 3598–3612.
mla: Liu, D., et al. “Endocytosis of BRASSINOSTEROID INSENSITIVE1 Is Partly Driven
by a Canonical Tyrosine-Based Motif.” Plant Cell, vol. 32, no. 11, American
Society of Plant Biologists, 2020, pp. 3598–612, doi:10.1105/tpc.20.00384.
short: D. Liu, R. Kumar, C. LAN, A.J. Johnson, W. Siao, I. Vanhoutte, P. Wang, K.
Bender, K. Yperman, S. Martins, X. Zhao, G. Vert, D. Van Damme, J. Friml, E. Russinova,
Plant Cell 32 (2020) 3598–3612.
date_created: 2020-10-05T12:45:16Z
date_published: 2020-11-01T00:00:00Z
date_updated: 2023-09-05T12:21:32Z
day: '01'
department:
- _id: JiFr
doi: 10.1105/tpc.20.00384
ec_funded: 1
external_id:
isi:
- '000600226800021'
pmid:
- '32958564'
intvolume: ' 32'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/MED/32958564
month: '11'
oa: 1
oa_version: Published Version
page: 3598-3612
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: Plant Cell
publication_identifier:
eissn:
- 1532-298x
issn:
- 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Endocytosis of BRASSINOSTEROID INSENSITIVE1 is partly driven by a canonical
tyrosine-based Motif
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2020'
...
---
_id: '7695'
abstract:
- lang: eng
text: The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.
TPC in Arabidopsis (Arabidopsis thaliana) contains six evolutionarily conserved
subunits and two plant-specific subunits, AtEH1/Pan1 and AtEH2/Pan1, although
cytoplasmic proteins are not associated with the hexameric subcomplex in the cytoplasm.
To investigate the dynamic assembly of the octameric TPC at the plasma membrane
(PM), we performed state-of-the-art dual-color live cell imaging at physiological
and lowered temperatures. Lowering the temperature slowed down endocytosis, thereby
enhancing the temporal resolution of the differential recruitment of endocytic
components. Under both normal and lowered temperature conditions, the core TPC
subunit TPLATE and the AtEH/Pan1 proteins exhibited simultaneous recruitment at
the PM. These results, together with co-localization analysis of different TPC
subunits, allow us to conclude that TPC in plant cells is not recruited to the
PM sequentially but as an octameric complex.
article_processing_charge: No
article_type: original
author:
- first_name: J
full_name: Wang, J
last_name: Wang
- first_name: E
full_name: Mylle, E
last_name: Mylle
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: N
full_name: Besbrugge, N
last_name: Besbrugge
- first_name: G
full_name: De Jaeger, G
last_name: De Jaeger
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: R
full_name: Pleskot, R
last_name: Pleskot
- first_name: D
full_name: van Damme, D
last_name: van Damme
citation:
ama: Wang J, Mylle E, Johnson AJ, et al. High temporal resolution reveals simultaneous
plasma membrane recruitment of TPLATE complex subunits. Plant Physiology.
2020;183(3):986-997. doi:10.1104/pp.20.00178
apa: Wang, J., Mylle, E., Johnson, A. J., Besbrugge, N., De Jaeger, G., Friml, J.,
… van Damme, D. (2020). High temporal resolution reveals simultaneous plasma membrane
recruitment of TPLATE complex subunits. Plant Physiology. American Society
of Plant Biologists. https://doi.org/10.1104/pp.20.00178
chicago: Wang, J, E Mylle, Alexander J Johnson, N Besbrugge, G De Jaeger, Jiří Friml,
R Pleskot, and D van Damme. “High Temporal Resolution Reveals Simultaneous Plasma
Membrane Recruitment of TPLATE Complex Subunits.” Plant Physiology. American
Society of Plant Biologists, 2020. https://doi.org/10.1104/pp.20.00178.
ieee: J. Wang et al., “High temporal resolution reveals simultaneous plasma
membrane recruitment of TPLATE complex subunits,” Plant Physiology, vol.
183, no. 3. American Society of Plant Biologists, pp. 986–997, 2020.
ista: Wang J, Mylle E, Johnson AJ, Besbrugge N, De Jaeger G, Friml J, Pleskot R,
van Damme D. 2020. High temporal resolution reveals simultaneous plasma membrane
recruitment of TPLATE complex subunits. Plant Physiology. 183(3), 986–997.
mla: Wang, J., et al. “High Temporal Resolution Reveals Simultaneous Plasma Membrane
Recruitment of TPLATE Complex Subunits.” Plant Physiology, vol. 183, no.
3, American Society of Plant Biologists, 2020, pp. 986–97, doi:10.1104/pp.20.00178.
short: J. Wang, E. Mylle, A.J. Johnson, N. Besbrugge, G. De Jaeger, J. Friml, R.
Pleskot, D. van Damme, Plant Physiology 183 (2020) 986–997.
date_created: 2020-04-29T15:23:00Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-09-05T12:20:02Z
day: '01'
department:
- _id: JiFr
doi: 10.1104/pp.20.00178
external_id:
isi:
- '000550682000018'
pmid:
- '32321842'
intvolume: ' 183'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.02.13.948109
month: '07'
oa: 1
oa_version: Preprint
page: 986-997
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Plant Physiology
publication_identifier:
eissn:
- 1532-2548
issn:
- 0032-0889
publication_status: published
publisher: American Society of Plant Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: High temporal resolution reveals simultaneous plasma membrane recruitment of
TPLATE complex subunits
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 183
year: '2020'
...
---
_id: '9197'
abstract:
- lang: eng
text: In this paper we introduce and study all-pay bidding games, a class of two
player, zero-sum games on graphs. The game proceeds as follows. We place a token
on some vertex in the graph and assign budgets to the two players. Each turn,
each player submits a sealed legal bid (non-negative and below their remaining
budget), which is deducted from their budget and the highest bidder moves the
token onto an adjacent vertex. The game ends once a sink is reached, and Player
1 pays Player 2 the outcome that is associated with the sink. The players attempt
to maximize their expected outcome. Our games model settings where effort (of
no inherent value) needs to be invested in an ongoing and stateful manner. On
the negative side, we show that even in simple games on DAGs, optimal strategies
may require a distribution over bids with infinite support. A central quantity
in bidding games is the ratio of the players budgets. On the positive side, we
show a simple FPTAS for DAGs, that, for each budget ratio, outputs an approximation
for the optimal strategy for that ratio. We also implement it, show that it performs
well, and suggests interesting properties of these games. Then, given an outcome
c, we show an algorithm for finding the necessary and sufficient initial ratio
for guaranteeing outcome c with probability 1 and a strategy ensuring such. Finally,
while the general case has not previously been studied, solving the specific game
in which Player 1 wins iff he wins the first two auctions, has been long stated
as an open question, which we solve.
acknowledgement: This research was supported by the Austrian Science Fund (FWF) under
grants S11402-N23 (RiSE/SHiNE), Z211-N23 (Wittgenstein Award), and M 2369-N33 (Meitner
fellowship).
article_processing_charge: No
article_type: original
author:
- first_name: Guy
full_name: Avni, Guy
id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
last_name: Avni
orcid: 0000-0001-5588-8287
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
citation:
ama: Avni G, Ibsen-Jensen R, Tkadlec J. All-pay bidding games on graphs. Proceedings
of the AAAI Conference on Artificial Intelligence. 2020;34(02):1798-1805.
doi:10.1609/aaai.v34i02.5546
apa: 'Avni, G., Ibsen-Jensen, R., & Tkadlec, J. (2020). All-pay bidding games
on graphs. Proceedings of the AAAI Conference on Artificial Intelligence.
New York, NY, United States: Association for the Advancement of Artificial Intelligence.
https://doi.org/10.1609/aaai.v34i02.5546'
chicago: Avni, Guy, Rasmus Ibsen-Jensen, and Josef Tkadlec. “All-Pay Bidding Games
on Graphs.” Proceedings of the AAAI Conference on Artificial Intelligence.
Association for the Advancement of Artificial Intelligence, 2020. https://doi.org/10.1609/aaai.v34i02.5546.
ieee: G. Avni, R. Ibsen-Jensen, and J. Tkadlec, “All-pay bidding games on graphs,”
Proceedings of the AAAI Conference on Artificial Intelligence, vol. 34,
no. 02. Association for the Advancement of Artificial Intelligence, pp. 1798–1805,
2020.
ista: Avni G, Ibsen-Jensen R, Tkadlec J. 2020. All-pay bidding games on graphs.
Proceedings of the AAAI Conference on Artificial Intelligence. 34(02), 1798–1805.
mla: Avni, Guy, et al. “All-Pay Bidding Games on Graphs.” Proceedings of the
AAAI Conference on Artificial Intelligence, vol. 34, no. 02, Association for
the Advancement of Artificial Intelligence, 2020, pp. 1798–805, doi:10.1609/aaai.v34i02.5546.
short: G. Avni, R. Ibsen-Jensen, J. Tkadlec, Proceedings of the AAAI Conference
on Artificial Intelligence 34 (2020) 1798–1805.
conference:
end_date: 2020-02-12
location: New York, NY, United States
name: 'AAAI: Conference on Artificial Intelligence'
start_date: 2020-02-07
date_created: 2021-02-25T09:05:18Z
date_published: 2020-04-03T00:00:00Z
date_updated: 2023-09-05T12:40:00Z
day: '03'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1609/aaai.v34i02.5546
external_id:
arxiv:
- '1911.08360'
intvolume: ' 34'
issue: '02'
language:
- iso: eng
month: '04'
oa_version: Preprint
page: 1798-1805
project:
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 264B3912-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02369
name: Formal Methods meets Algorithmic Game Theory
publication: Proceedings of the AAAI Conference on Artificial Intelligence
publication_identifier:
eissn:
- 2374-3468
isbn:
- '9781577358350'
issn:
- 2159-5399
publication_status: published
publisher: Association for the Advancement of Artificial Intelligence
quality_controlled: '1'
scopus_import: '1'
status: public
title: All-pay bidding games on graphs
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 34
year: '2020'
...
---
_id: '8142'
abstract:
- lang: eng
text: Cell production and differentiation for the acquisition of specific functions
are key features of living systems. The dynamic network of cellular microtubules
provides the necessary platform to accommodate processes associated with the transition
of cells through the individual phases of cytogenesis. Here, we show that the
plant hormone cytokinin fine‐tunes the activity of the microtubular cytoskeleton
during cell differentiation and counteracts microtubular rearrangements driven
by the hormone auxin. The endogenous upward gradient of cytokinin activity along
the longitudinal growth axis in Arabidopsis thaliana roots correlates with robust
rearrangements of the microtubule cytoskeleton in epidermal cells progressing
from the proliferative to the differentiation stage. Controlled increases in cytokinin
activity result in premature re‐organization of the microtubule network from transversal
to an oblique disposition in cells prior to their differentiation, whereas attenuated
hormone perception delays cytoskeleton conversion into a configuration typical
for differentiated cells. Intriguingly, cytokinin can interfere with microtubules
also in animal cells, such as leukocytes, suggesting that a cytokinin‐sensitive
control pathway for the microtubular cytoskeleton may be at least partially conserved
between plant and animal cells.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank Takashi Aoyama, David Alabadi, and Bert De Rybel for sharing
material, Jiří Friml, Maciek Adamowski, and Katerina Schwarzerová for inspiring
discussions, and Martine De Cock for help in preparing the manuscript. This research
was supported by the Scientific Service Units (SSUs) of IST Austria through resources
provided by the Bioimaging Facility (BIF), especially to Robert Hauschild; and the
Life Science Facility (LSF). J.C.M. is the recipient of a EMBO Long‐Term Fellowship
(ALTF number 710‐2016). This work was supported with MEYS CR, project no.CZ.02.1.01/0.0/0.0/16_019/0000738
to J.P., and by the Austrian Science Fund (FWF01_I1774S) to E.B.
article_number: e104238
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Juan C
full_name: Montesinos López, Juan C
id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
last_name: Montesinos López
orcid: 0000-0001-9179-6099
- first_name: A
full_name: Abuzeineh, A
last_name: Abuzeineh
- first_name: Aglaja
full_name: Kopf, Aglaja
id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
last_name: Kopf
orcid: 0000-0002-2187-6656
- first_name: Alba
full_name: Juanes Garcia, Alba
id: 40F05888-F248-11E8-B48F-1D18A9856A87
last_name: Juanes Garcia
orcid: 0000-0002-1009-9652
- first_name: Krisztina
full_name: Ötvös, Krisztina
id: 29B901B0-F248-11E8-B48F-1D18A9856A87
last_name: Ötvös
orcid: 0000-0002-5503-4983
- first_name: J
full_name: Petrášek, J
last_name: Petrášek
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Montesinos López JC, Abuzeineh A, Kopf A, et al. Phytohormone cytokinin guides
microtubule dynamics during cell progression from proliferative to differentiated
stage. The Embo Journal. 2020;39(17). doi:10.15252/embj.2019104238
apa: Montesinos López, J. C., Abuzeineh, A., Kopf, A., Juanes Garcia, A., Ötvös,
K., Petrášek, J., … Benková, E. (2020). Phytohormone cytokinin guides microtubule
dynamics during cell progression from proliferative to differentiated stage. The
Embo Journal. Embo Press. https://doi.org/10.15252/embj.2019104238
chicago: Montesinos López, Juan C, A Abuzeineh, Aglaja Kopf, Alba Juanes Garcia,
Krisztina Ötvös, J Petrášek, Michael K Sixt, and Eva Benková. “Phytohormone Cytokinin
Guides Microtubule Dynamics during Cell Progression from Proliferative to Differentiated
Stage.” The Embo Journal. Embo Press, 2020. https://doi.org/10.15252/embj.2019104238.
ieee: J. C. Montesinos López et al., “Phytohormone cytokinin guides microtubule
dynamics during cell progression from proliferative to differentiated stage,”
The Embo Journal, vol. 39, no. 17. Embo Press, 2020.
ista: Montesinos López JC, Abuzeineh A, Kopf A, Juanes Garcia A, Ötvös K, Petrášek
J, Sixt MK, Benková E. 2020. Phytohormone cytokinin guides microtubule dynamics
during cell progression from proliferative to differentiated stage. The Embo Journal.
39(17), e104238.
mla: Montesinos López, Juan C., et al. “Phytohormone Cytokinin Guides Microtubule
Dynamics during Cell Progression from Proliferative to Differentiated Stage.”
The Embo Journal, vol. 39, no. 17, e104238, Embo Press, 2020, doi:10.15252/embj.2019104238.
short: J.C. Montesinos López, A. Abuzeineh, A. Kopf, A. Juanes Garcia, K. Ötvös,
J. Petrášek, M.K. Sixt, E. Benková, The Embo Journal 39 (2020).
date_created: 2020-07-21T09:08:38Z
date_published: 2020-09-01T00:00:00Z
date_updated: 2023-09-05T13:05:47Z
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department:
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doi: 10.15252/embj.2019104238
external_id:
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title: Phytohormone cytokinin guides microtubule dynamics during cell progression
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