---
_id: '10408'
abstract:
- lang: eng
text: 'Key trees are often the best solution in terms of transmission cost and storage
requirements for managing keys in a setting where a group needs to share a secret
key, while being able to efficiently rotate the key material of users (in order
to recover from a potential compromise, or to add or remove users). Applications
include multicast encryption protocols like LKH (Logical Key Hierarchies) or group
messaging like the current IETF proposal TreeKEM. A key tree is a (typically balanced)
binary tree, where each node is identified with a key: leaf nodes hold users’
secret keys while the root is the shared group key. For a group of size N, each
user just holds log(N) keys (the keys on the path from its leaf to the root)
and its entire key material can be rotated by broadcasting 2log(N) ciphertexts
(encrypting each fresh key on the path under the keys of its parents). In this
work we consider the natural setting where we have many groups with partially
overlapping sets of users, and ask if we can find solutions where the cost of
rotating a key is better than in the trivial one where we have a separate key
tree for each group. We show that in an asymptotic setting (where the number m
of groups is fixed while the number N of users grows) there exist more general
key graphs whose cost converges to the cost of a single group, thus saving a factor
linear in the number of groups over the trivial solution. As our asymptotic “solution”
converges very slowly and performs poorly on concrete examples, we propose an
algorithm that uses a natural heuristic to compute a key graph for any given group
structure. Our algorithm combines two greedy algorithms, and is thus very efficient:
it first converts the group structure into a “lattice graph”, which is then turned
into a key graph by repeatedly applying the algorithm for constructing a Huffman
code. To better understand how far our proposal is from an optimal solution, we
prove lower bounds on the update cost of continuous group-key agreement and multicast
encryption in a symbolic model admitting (asymmetric) encryption, pseudorandom
generators, and secret sharing as building blocks.'
acknowledgement: B. Auerbach, M.A. Baig and K. Pietrzak—received funding from the
European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (682815 - TOCNeT); Karen Klein was supported in part by
ERC CoG grant 724307 and conducted part of this work at IST Austria, funded by the
ERC under the European Union’s Horizon 2020 research and innovation programme (682815
- TOCNeT); Guillermo Pascual-Perez was funded by the European Union’s Horizon 2020
research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 665385; Michael Walter conducted part of this work at IST Austria, funded by
the ERC under the European Union’s Horizon 2020 research and innovation programme
(682815 - TOCNeT).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joel F
full_name: Alwen, Joel F
id: 2A8DFA8C-F248-11E8-B48F-1D18A9856A87
last_name: Alwen
- first_name: Benedikt
full_name: Auerbach, Benedikt
id: D33D2B18-E445-11E9-ABB7-15F4E5697425
last_name: Auerbach
orcid: 0000-0002-7553-6606
- first_name: Mirza Ahad
full_name: Baig, Mirza Ahad
id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425
last_name: Baig
- first_name: Miguel
full_name: Cueto Noval, Miguel
id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
last_name: Cueto Noval
- first_name: Karen
full_name: Klein, Karen
id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
last_name: Klein
- first_name: Guillermo
full_name: Pascual Perez, Guillermo
id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
last_name: Pascual Perez
orcid: 0000-0001-8630-415X
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Michael
full_name: Walter, Michael
id: 488F98B0-F248-11E8-B48F-1D18A9856A87
last_name: Walter
orcid: 0000-0003-3186-2482
citation:
ama: 'Alwen JF, Auerbach B, Baig MA, et al. Grafting key trees: Efficient key management
for overlapping groups. In: 19th International Conference. Vol 13044. Springer
Nature; 2021:222-253. doi:10.1007/978-3-030-90456-2_8'
apa: 'Alwen, J. F., Auerbach, B., Baig, M. A., Cueto Noval, M., Klein, K., Pascual
Perez, G., … Walter, M. (2021). Grafting key trees: Efficient key management for
overlapping groups. In 19th International Conference (Vol. 13044, pp. 222–253).
Raleigh, NC, United States: Springer Nature. https://doi.org/10.1007/978-3-030-90456-2_8'
chicago: 'Alwen, Joel F, Benedikt Auerbach, Mirza Ahad Baig, Miguel Cueto Noval,
Karen Klein, Guillermo Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter.
“Grafting Key Trees: Efficient Key Management for Overlapping Groups.” In 19th
International Conference, 13044:222–53. Springer Nature, 2021. https://doi.org/10.1007/978-3-030-90456-2_8.'
ieee: 'J. F. Alwen et al., “Grafting key trees: Efficient key management
for overlapping groups,” in 19th International Conference, Raleigh, NC,
United States, 2021, vol. 13044, pp. 222–253.'
ista: 'Alwen JF, Auerbach B, Baig MA, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak
KZ, Walter M. 2021. Grafting key trees: Efficient key management for overlapping
groups. 19th International Conference. TCC: Theory of Cryptography, LNCS, vol.
13044, 222–253.'
mla: 'Alwen, Joel F., et al. “Grafting Key Trees: Efficient Key Management for Overlapping
Groups.” 19th International Conference, vol. 13044, Springer Nature, 2021,
pp. 222–53, doi:10.1007/978-3-030-90456-2_8.'
short: J.F. Alwen, B. Auerbach, M.A. Baig, M. Cueto Noval, K. Klein, G. Pascual
Perez, K.Z. Pietrzak, M. Walter, in:, 19th International Conference, Springer
Nature, 2021, pp. 222–253.
conference:
end_date: 2021-11-11
location: Raleigh, NC, United States
name: 'TCC: Theory of Cryptography'
start_date: 2021-11-08
date_created: 2021-12-05T23:01:42Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T13:19:39Z
day: '04'
department:
- _id: KrPi
doi: 10.1007/978-3-030-90456-2_8
ec_funded: 1
external_id:
isi:
- '000728363700008'
intvolume: ' 13044'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2021/1158
month: '11'
oa: 1
oa_version: Preprint
page: 222-253
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: 19th International Conference
publication_identifier:
eisbn:
- 978-3-030-90456-2
eissn:
- 1611-3349
isbn:
- 9-783-0309-0455-5
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Grafting key trees: Efficient key management for overlapping groups'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13044
year: '2021'
...
---
_id: '10527'
abstract:
- lang: eng
text: We show that in a two-dimensional electron gas with an annular Fermi surface,
long-range Coulomb interactions can lead to unconventional superconductivity by
the Kohn-Luttinger mechanism. Superconductivity is strongly enhanced when the
inner and outer Fermi surfaces are close to each other. The most prevalent state
has chiral p-wave symmetry, but d-wave and extended s-wave pairing are also possible.
We discuss these results in the context of rhombohedral trilayer graphene, where
superconductivity was recently discovered in regimes where the normal state has
an annular Fermi surface. Using realistic parameters, our mechanism can account
for the order of magnitude of Tc, as well as its trends as a function of electron
density and perpendicular displacement field. Moreover, it naturally explains
some of the outstanding puzzles in this material, that include the weak temperature
dependence of the resistivity above Tc, and the proximity of spin singlet superconductivity
to the ferromagnetic phase.
acknowledgement: We thank Yang-Zhi Chou, Andrey Chubukov, Johannes Hofmann, Steve
Kivelson, Sri Raghu, and Sankar das Sarma, Jay Sau, Fengcheng Wu, and Andrea Young
for many stimulating discussions and for their comments on the manuscript. E.B.
thanks S. Chatterjee, T. Wang, and M. Zaletel for a collaboration on a related topic.
A.G. acknowledges support by the European Unions Horizon 2020 research and innovation
program under the Marie Sklodowska-Curie Grant Agreement No. 754411. E.B. and T.H.
were supported by the European Research Council (ERC) under grant HQMAT (Grant Agreement
No. 817799), by the Israel-USA Binational Science Foundation (BSF), and by a Research
grant from Irving and Cherna Moskowitz.
article_number: '247001'
article_processing_charge: No
article_type: original
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: Tobias
full_name: Holder, Tobias
last_name: Holder
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Erez
full_name: Berg, Erez
last_name: Berg
citation:
ama: 'Ghazaryan A, Holder T, Serbyn M, Berg E. Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene.
Physical Review Letters. 2021;127(24). doi:10.1103/physrevlett.127.247001'
apa: 'Ghazaryan, A., Holder, T., Serbyn, M., & Berg, E. (2021). Unconventional
superconductivity in systems with annular Fermi surfaces: Application to rhombohedral
trilayer graphene. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/physrevlett.127.247001'
chicago: 'Ghazaryan, Areg, Tobias Holder, Maksym Serbyn, and Erez Berg. “Unconventional
Superconductivity in Systems with Annular Fermi Surfaces: Application to Rhombohedral
Trilayer Graphene.” Physical Review Letters. American Physical Society,
2021. https://doi.org/10.1103/physrevlett.127.247001.'
ieee: 'A. Ghazaryan, T. Holder, M. Serbyn, and E. Berg, “Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene,”
Physical Review Letters, vol. 127, no. 24. American Physical Society, 2021.'
ista: 'Ghazaryan A, Holder T, Serbyn M, Berg E. 2021. Unconventional superconductivity
in systems with annular Fermi surfaces: Application to rhombohedral trilayer graphene.
Physical Review Letters. 127(24), 247001.'
mla: 'Ghazaryan, Areg, et al. “Unconventional Superconductivity in Systems with
Annular Fermi Surfaces: Application to Rhombohedral Trilayer Graphene.” Physical
Review Letters, vol. 127, no. 24, 247001, American Physical Society, 2021,
doi:10.1103/physrevlett.127.247001.'
short: A. Ghazaryan, T. Holder, M. Serbyn, E. Berg, Physical Review Letters 127
(2021).
date_created: 2021-12-10T07:51:33Z
date_published: 2021-12-09T00:00:00Z
date_updated: 2023-08-14T13:19:13Z
day: '09'
department:
- _id: MaSe
doi: 10.1103/physrevlett.127.247001
ec_funded: 1
external_id:
arxiv:
- '2109.00011'
isi:
- '000923819400004'
intvolume: ' 127'
isi: 1
issue: '24'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2109.00011
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/resolving-the-puzzles-of-graphene-superconductivity/
scopus_import: '1'
status: public
title: 'Unconventional superconductivity in systems with annular Fermi surfaces: Application
to rhombohedral trilayer graphene'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 127
year: '2021'
...
---
_id: '10534'
abstract:
- lang: eng
text: For many years, fullerene derivatives have been the main n-type material of
organic electronics and optoelectronics. Recently, fullerene derivatives functionalized
with ethylene glycol (EG) side chains have been showing important properties such
as enhanced dielectric constants, facile doping and enhanced self-assembly capabilities.
Here, we have prepared field-effect transistors using a series of these fullerene
derivatives equipped with EG side chains of different lengths. Transport data
show the beneficial effect of increasing the EG side chain. In order to understand
the material properties, full structural determination of these fullerene derivatives
has been achieved by coupling the X-ray data with molecular dynamics (MD) simulations.
The increase in transport properties is paired with the formation of extended
layered structures, efficient molecular packing and an increase in the crystallite
alignment. The layer-like structure is composed of conducting layers, containing
of closely packed C60 balls approaching the inter-distance of 1 nm, that are separated
by well-defined EG layers, where the EG chains are rather splayed with the chain
direction almost perpendicular to the layer normal. Such a layered structure appears
highly ordered and highly aligned with the C60 planes oriented parallel to the
substrate in the thin film configuration. The order inside the thin film increases
with the EG chain length, allowing the systems to achieve mobilities as high as
0.053 cm2 V−1 s−1. Our work elucidates the structure of these interesting semiconducting
organic molecules and shows that the synergistic use of X-ray structural analysis
and MD simulations is a powerful tool to identify the structure of thin organic
films for optoelectronic applications.
acknowledgement: J. D. gratefully acknowledges the China Scholarship Council (CSC
No. 201606340158) for supporting his PhD studies. S. S. thanks J. Antoja-Lleonart
for insightful discussions on simulating the X-ray diffraction patterns. Part of
the work was sponsored by NWO Exact and Natural Sciences for the use of supercomputer
facilities (Contract no. 17197 7095). Regarding S. S., R. A., R. W. A. H., J. C.
H., and M. A. L., this is a publication by the FOM Focus Group “Next Generation
Organic Photovoltaics”, participating in the Dutch Institute for Fundamental Energy
Research (DIFFER). The ESRF is acknowledged for providing the beamtime. J. D. and
G. P. are grateful to the BM26B staff for their great support during the beamtime.
M. A. L., D. M. B. are grateful for the financial support of the European Research
Council via a Starting Grant (HySPOD, No. 306983).
article_processing_charge: No
article_type: original
author:
- first_name: Jingjin
full_name: Dong, Jingjin
last_name: Dong
- first_name: Selim
full_name: Sami, Selim
last_name: Sami
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Riccardo
full_name: Alessandri, Riccardo
last_name: Alessandri
- first_name: Fatimeh
full_name: Jahani, Fatimeh
last_name: Jahani
- first_name: Li
full_name: Qiu, Li
last_name: Qiu
- first_name: Siewert J.
full_name: Marrink, Siewert J.
last_name: Marrink
- first_name: Remco W.A.
full_name: Havenith, Remco W.A.
last_name: Havenith
- first_name: Jan C.
full_name: Hummelen, Jan C.
last_name: Hummelen
- first_name: Maria A.
full_name: Loi, Maria A.
last_name: Loi
- first_name: Giuseppe
full_name: Portale, Giuseppe
last_name: Portale
citation:
ama: 'Dong J, Sami S, Balazs D, et al. Fullerene derivatives with oligoethylene-glycol
side chains: An investigation on the origin of their outstanding transport properties.
Journal of Materials Chemistry C. 2021;9(45):16217-16225. doi:10.1039/d1tc02753k'
apa: 'Dong, J., Sami, S., Balazs, D., Alessandri, R., Jahani, F., Qiu, L., … Portale,
G. (2021). Fullerene derivatives with oligoethylene-glycol side chains: An investigation
on the origin of their outstanding transport properties. Journal of Materials
Chemistry C. Royal Society of Chemistry. https://doi.org/10.1039/d1tc02753k'
chicago: 'Dong, Jingjin, Selim Sami, Daniel Balazs, Riccardo Alessandri, Fatimeh
Jahani, Li Qiu, Siewert J. Marrink, et al. “Fullerene Derivatives with Oligoethylene-Glycol
Side Chains: An Investigation on the Origin of Their Outstanding Transport Properties.”
Journal of Materials Chemistry C. Royal Society of Chemistry, 2021. https://doi.org/10.1039/d1tc02753k.'
ieee: 'J. Dong et al., “Fullerene derivatives with oligoethylene-glycol side
chains: An investigation on the origin of their outstanding transport properties,”
Journal of Materials Chemistry C, vol. 9, no. 45. Royal Society of Chemistry,
pp. 16217–16225, 2021.'
ista: 'Dong J, Sami S, Balazs D, Alessandri R, Jahani F, Qiu L, Marrink SJ, Havenith
RWA, Hummelen JC, Loi MA, Portale G. 2021. Fullerene derivatives with oligoethylene-glycol
side chains: An investigation on the origin of their outstanding transport properties.
Journal of Materials Chemistry C. 9(45), 16217–16225.'
mla: 'Dong, Jingjin, et al. “Fullerene Derivatives with Oligoethylene-Glycol Side
Chains: An Investigation on the Origin of Their Outstanding Transport Properties.”
Journal of Materials Chemistry C, vol. 9, no. 45, Royal Society of Chemistry,
2021, pp. 16217–25, doi:10.1039/d1tc02753k.'
short: J. Dong, S. Sami, D. Balazs, R. Alessandri, F. Jahani, L. Qiu, S.J. Marrink,
R.W.A. Havenith, J.C. Hummelen, M.A. Loi, G. Portale, Journal of Materials Chemistry
C 9 (2021) 16217–16225.
date_created: 2021-12-12T23:01:27Z
date_published: 2021-12-07T00:00:00Z
date_updated: 2023-08-17T06:18:44Z
day: '07'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1039/d1tc02753k
external_id:
isi:
- '000688135700001'
file:
- access_level: open_access
checksum: 6b73c214ce54a6894a5854b4364413d7
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-13T09:24:42Z
date_updated: 2021-12-13T09:24:42Z
file_id: '10538'
file_name: 2021_JMaterChemC_Dong.pdf
file_size: 4979390
relation: main_file
success: 1
file_date_updated: 2021-12-13T09:24:42Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '45'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 16217-16225
publication: Journal of Materials Chemistry C
publication_identifier:
eissn:
- 2050-7526
issn:
- 2050-7534
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Fullerene derivatives with oligoethylene-glycol side chains: An investigation
on the origin of their outstanding transport properties'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '10533'
abstract:
- lang: eng
text: Flowering plants utilize small RNA molecules to guide DNA methyltransferases
to genomic sequences. This RNA-directed DNA methylation (RdDM) pathway preferentially
targets euchromatic transposable elements. However, RdDM is thought to be recruited
by methylation of histone H3 at lysine 9 (H3K9me), a hallmark of heterochromatin.
How RdDM is targeted to euchromatin despite an affinity for H3K9me is unclear.
Here we show that loss of histone H1 enhances heterochromatic RdDM, preferentially
at nucleosome linker DNA. Surprisingly, this does not require SHH1, the RdDM component
that binds H3K9me. Furthermore, H3K9me is dispensable for RdDM, as is CG DNA methylation.
Instead, we find that non-CG methylation is specifically associated with small
RNA biogenesis, and without H1 small RNA production quantitatively expands to
non-CG methylated loci. Our results demonstrate that H1 enforces the separation
of euchromatic and heterochromatic DNA methylation pathways by excluding the small
RNA-generating branch of RdDM from non-CG methylated heterochromatin.
acknowledgement: We thank X Feng for helpful comments on the manuscript. This work
was supported by a European Research Council grant MaintainMeth (725746) to DZ.
article_number: e72676
article_processing_charge: No
article_type: original
author:
- first_name: Jaemyung
full_name: Choi, Jaemyung
last_name: Choi
- first_name: David B
full_name: Lyons, David B
last_name: Lyons
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Choi J, Lyons DB, Zilberman D. Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin. eLife. 2021;10. doi:10.7554/elife.72676
apa: Choi, J., Lyons, D. B., & Zilberman, D. (2021). Histone H1 prevents non-CG
methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin. ELife.
eLife Sciences Publications. https://doi.org/10.7554/elife.72676
chicago: Choi, Jaemyung, David B Lyons, and Daniel Zilberman. “Histone H1 Prevents
Non-CG Methylation-Mediated Small RNA Biogenesis in Arabidopsis Heterochromatin.”
ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.72676.
ieee: J. Choi, D. B. Lyons, and D. Zilberman, “Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin,” eLife, vol. 10. eLife
Sciences Publications, 2021.
ista: Choi J, Lyons DB, Zilberman D. 2021. Histone H1 prevents non-CG methylation-mediated
small RNA biogenesis in Arabidopsis heterochromatin. eLife. 10, e72676.
mla: Choi, Jaemyung, et al. “Histone H1 Prevents Non-CG Methylation-Mediated Small
RNA Biogenesis in Arabidopsis Heterochromatin.” ELife, vol. 10, e72676,
eLife Sciences Publications, 2021, doi:10.7554/elife.72676.
short: J. Choi, D.B. Lyons, D. Zilberman, ELife 10 (2021).
date_created: 2021-12-10T13:12:08Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2023-08-17T06:21:08Z
day: '01'
ddc:
- '570'
department:
- _id: DaZi
doi: 10.7554/elife.72676
ec_funded: 1
external_id:
isi:
- '000754832000001'
pmid:
- '34850679'
file:
- access_level: open_access
checksum: 22ed4c55fb550f6da02ae55c359be651
content_type: application/pdf
creator: dernst
date_created: 2022-05-16T10:42:22Z
date_updated: 2022-05-16T10:42:22Z
file_id: '11384'
file_name: 2021_eLife_Choi.pdf
file_size: 2715200
relation: main_file
success: 1
file_date_updated: 2022-05-16T10:42:22Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- genetics and molecular biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 62935a00-2b32-11ec-9570-eff30fa39068
call_identifier: H2020
grant_number: '725746'
name: Quantitative analysis of DNA methylation maintenance with chromatin
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis
heterochromatin
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10536'
abstract:
- lang: eng
text: TGFβ overexpression is commonly detected in cancer patients and correlates
with poor prognosis and metastasis. Cancer progression is often associated with
an enhanced recruitment of myeloid-derived cells to the tumor microenvironment.
Here we show that functional TGFβ-signaling in myeloid cells is required for metastasis
to the lungs and the liver. Myeloid-specific deletion of Tgfbr2 resulted in reduced
spontaneous lung metastasis, which was associated with a reduction of proinflammatory
cytokines in the metastatic microenvironment. Notably, CD8+ T cell depletion in
myeloid-specific Tgfbr2-deficient mice rescued lung metastasis. Myeloid-specific
Tgfbr2-deficiency resulted in reduced liver metastasis with an almost complete
absence of myeloid cells within metastatic foci. On contrary, an accumulation
of Tgfβ-responsive myeloid cells was associated with an increased recruitment
of monocytes and granulocytes and higher proinflammatory cytokine levels in control
mice. Monocytic cells isolated from metastatic livers of Tgfbr2-deficient mice
showed increased polarization towards the M1 phenotype, Tnfα and Il-1β expression,
reduced levels of M2 markers and reduced production of chemokines responsible
for myeloid-cell recruitment. No significant differences in Tgfβ levels were observed
at metastatic sites of any model. These data demonstrate that Tgfβ signaling in
monocytic myeloid cells suppresses CD8+ T cell activity during lung metastasis,
while these cells actively contribute to tumor growth during liver metastasis.
Thus, myeloid cells modulate metastasis through different mechanisms in a tissue-specific
manner.
acknowledgement: The authors acknowledge the assistance of the Laboratory Animal Services
Center (LASC) – UZH, Center for Microscopy and Image Analysis, and the Flow Cytometry
Center of the University of Zurich.
article_number: '765151'
article_processing_charge: No
article_type: original
author:
- first_name: Cristina
full_name: Stefanescu, Cristina
last_name: Stefanescu
- first_name: Merel
full_name: Van Gogh, Merel
last_name: Van Gogh
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: Mathias
full_name: Heikenwalder, Mathias
last_name: Heikenwalder
- first_name: Lubor
full_name: Borsig, Lubor
last_name: Borsig
citation:
ama: Stefanescu C, Van Gogh M, Roblek M, Heikenwalder M, Borsig L. TGFβ signaling
in myeloid cells promotes lung and liver metastasis through different mechanisms.
Frontiers in Oncology. 2021;11. doi:10.3389/fonc.2021.765151
apa: Stefanescu, C., Van Gogh, M., Roblek, M., Heikenwalder, M., & Borsig, L.
(2021). TGFβ signaling in myeloid cells promotes lung and liver metastasis through
different mechanisms. Frontiers in Oncology. Frontiers. https://doi.org/10.3389/fonc.2021.765151
chicago: Stefanescu, Cristina, Merel Van Gogh, Marko Roblek, Mathias Heikenwalder,
and Lubor Borsig. “TGFβ Signaling in Myeloid Cells Promotes Lung and Liver Metastasis
through Different Mechanisms.” Frontiers in Oncology. Frontiers, 2021.
https://doi.org/10.3389/fonc.2021.765151.
ieee: C. Stefanescu, M. Van Gogh, M. Roblek, M. Heikenwalder, and L. Borsig, “TGFβ
signaling in myeloid cells promotes lung and liver metastasis through different
mechanisms,” Frontiers in Oncology, vol. 11. Frontiers, 2021.
ista: Stefanescu C, Van Gogh M, Roblek M, Heikenwalder M, Borsig L. 2021. TGFβ signaling
in myeloid cells promotes lung and liver metastasis through different mechanisms.
Frontiers in Oncology. 11, 765151.
mla: Stefanescu, Cristina, et al. “TGFβ Signaling in Myeloid Cells Promotes Lung
and Liver Metastasis through Different Mechanisms.” Frontiers in Oncology,
vol. 11, 765151, Frontiers, 2021, doi:10.3389/fonc.2021.765151.
short: C. Stefanescu, M. Van Gogh, M. Roblek, M. Heikenwalder, L. Borsig, Frontiers
in Oncology 11 (2021).
date_created: 2021-12-12T23:01:27Z
date_published: 2021-11-18T00:00:00Z
date_updated: 2023-08-17T06:20:32Z
day: '18'
ddc:
- '610'
department:
- _id: DaSi
doi: 10.3389/fonc.2021.765151
external_id:
isi:
- '000726603400001'
pmid:
- '34868988'
file:
- access_level: open_access
checksum: 56cbac80e6891ce750511a30161b7792
content_type: application/pdf
creator: alisjak
date_created: 2021-12-13T13:32:37Z
date_updated: 2021-12-13T13:32:37Z
file_id: '10539'
file_name: 2021_Frontiers_Stefanescu.pdf
file_size: 9245199
relation: main_file
success: 1
file_date_updated: 2021-12-13T13:32:37Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Oncology
publication_identifier:
eissn:
- 2234-943X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: TGFβ signaling in myeloid cells promotes lung and liver metastasis through
different mechanisms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...