---
_id: '12866'
abstract:
- lang: eng
text: "Autism spectrum disorder (ASD) and epilepsy are frequently comorbid neurodevelopmental
disorders. Extensive research has demonstrated shared pathological pathways, etiologies,
and phenotypes. Many risk factors for these disorders, like genetic mutations
and environmental pressures, are linked to changes in childhood brain development,
which is a critical period for their manifestation.\r\nDecades of research have
yielded many signatures for ASD and epilepsy, some shared and others unique or
opposing. The anatomical, physiological, and behavioral correlates of these disorders
are discussed in this chapter in the context of understanding shared pathological
pathways. We end with important takeaways on the presentation, prevention, intervention,
and policy changes for ASD and epilepsy. This chapter aims to explore the complexity
of these disorders, both in etiology and phenotypes, with the further goal of
appreciating the expanse of unknowns still to explore about the brain."
alternative_title:
- 'Vol. 1: Biological Development and Physical Health'
article_processing_charge: No
author:
- first_name: Christopher
full_name: Currin, Christopher
id: e8321fc5-3091-11eb-8a53-83f309a11ac9
last_name: Currin
orcid: 0000-0002-4809-5059
- first_name: Chad
full_name: Beyer, Chad
last_name: Beyer
citation:
ama: 'Currin C, Beyer C. Altered childhood brain development in autism and epilepsy.
In: Halpern-Felsher B, ed. Encyclopedia of Child and Adolescent Health.
1st ed. Elsevier; 2023:86-98. doi:10.1016/b978-0-12-818872-9.00129-1'
apa: Currin, C., & Beyer, C. (2023). Altered childhood brain development in
autism and epilepsy. In B. Halpern-Felsher (Ed.), Encyclopedia of Child and
Adolescent Health (1st ed., pp. 86–98). Elsevier. https://doi.org/10.1016/b978-0-12-818872-9.00129-1
chicago: Currin, Christopher, and Chad Beyer. “Altered Childhood Brain Development
in Autism and Epilepsy.” In Encyclopedia of Child and Adolescent Health,
edited by Bonnie Halpern-Felsher, 1st ed., 86–98. Elsevier, 2023. https://doi.org/10.1016/b978-0-12-818872-9.00129-1.
ieee: C. Currin and C. Beyer, “Altered childhood brain development in autism and
epilepsy,” in Encyclopedia of Child and Adolescent Health, 1st ed., B.
Halpern-Felsher, Ed. Elsevier, 2023, pp. 86–98.
ista: 'Currin C, Beyer C. 2023.Altered childhood brain development in autism and
epilepsy. In: Encyclopedia of Child and Adolescent Health. Vol. 1: Biological
Development and Physical Health, , 86–98.'
mla: Currin, Christopher, and Chad Beyer. “Altered Childhood Brain Development in
Autism and Epilepsy.” Encyclopedia of Child and Adolescent Health, edited
by Bonnie Halpern-Felsher, 1st ed., Elsevier, 2023, pp. 86–98, doi:10.1016/b978-0-12-818872-9.00129-1.
short: C. Currin, C. Beyer, in:, B. Halpern-Felsher (Ed.), Encyclopedia of Child
and Adolescent Health, 1st ed., Elsevier, 2023, pp. 86–98.
date_created: 2023-04-25T07:52:43Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-04-25T09:25:40Z
day: '01'
department:
- _id: TiVo
doi: 10.1016/b978-0-12-818872-9.00129-1
edition: '1'
editor:
- first_name: Bonnie
full_name: Halpern-Felsher, Bonnie
last_name: Halpern-Felsher
language:
- iso: eng
month: '02'
oa_version: None
page: 86-98
publication: Encyclopedia of Child and Adolescent Health
publication_identifier:
isbn:
- '9780128188736'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Altered childhood brain development in autism and epilepsy
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12809'
abstract:
- lang: eng
text: "Understanding the mechanisms of learning and memory formation has always
been one of\r\nthe main goals in neuroscience. Already Pavlov (1927) in his early
days has used his classic\r\nconditioning experiments to study the neural mechanisms
governing behavioral adaptation.\r\nWhat was not known back then was that the
part of the brain that is largely responsible for\r\nthis type of associative
learning is the cerebellum.\r\nSince then, plenty of theories on cerebellar learning
have emerged. Despite their differences,\r\none thing they all have in common
is that learning relies on synaptic and intrinsic plasticity.\r\nThe goal of my
PhD project was to unravel the molecular mechanisms underlying synaptic\r\nplasticity
in two synapses that have been shown to be implicated in motor learning, in an\r\neffort
to understand how learning and memory formation are processed in the cerebellum.\r\nOne
of the earliest and most well-known cerebellar theories postulates that motor
learning\r\nlargely depends on long-term depression at the parallel fiber-Purkinje
cell (PC-PC) synapse.\r\nHowever, the discovery of other types of plasticity in
the cerebellar circuitry, like long-term\r\npotentiation (LTP) at the PC-PC synapse,
potentiation of molecular layer interneurons (MLIs),\r\nand plasticity transfer
from the cortex to the cerebellar/ vestibular nuclei has increased the\r\npopularity
of the idea that multiple sites of plasticity might be involved in learning.\r\nStill
a lot remains unknown about the molecular mechanisms responsible for these types
of\r\nplasticity and whether they occur during physiological learning.\r\nIn the
first part of this thesis we have analyzed the variation and nanodistribution
of voltagegated calcium channels (VGCCs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid\r\ntype glutamate receptors (AMPARs) on the parallel fiber-Purkinje cell
synapse after vestibuloocular reflex phase reversal adaptation, a behavior that
has been suggested to rely on PF-PC\r\nLTP. We have found that on the last day
of adaptation there is no learning trace in form of\r\nVGCCs nor AMPARs variation
at the PF-PC synapse, but instead a decrease in the number of\r\nPF-PC synapses.
These data seem to support the view that learning is only stored in the\r\ncerebellar
cortex in an initial learning phase, being transferred later to the vestibular
nuclei.\r\nNext, we have studied the role of MLIs in motor learning using a relatively
simple and well characterized behavioral paradigm – horizontal optokinetic reflex
(HOKR) adaptation. We\r\nhave found behavior-induced MLI potentiation in form
of release probability increase that\r\ncould be explained by the increase of
VGCCs at the presynaptic side. Our results strengthen\r\nthe idea of distributed
cerebellar plasticity contributing to learning and provide a novel\r\nmechanism
for release probability increase. "
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Catarina
full_name: Alcarva, Catarina
id: 3A96634C-F248-11E8-B48F-1D18A9856A87
last_name: Alcarva
citation:
ama: 'Alcarva C. Plasticity in the cerebellum: What molecular mechanisms are behind
physiological learning. 2023. doi:10.15479/at:ista:12809'
apa: 'Alcarva, C. (2023). Plasticity in the cerebellum: What molecular mechanisms
are behind physiological learning. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:12809'
chicago: 'Alcarva, Catarina. “Plasticity in the Cerebellum: What Molecular Mechanisms
Are behind Physiological Learning.” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/at:ista:12809.'
ieee: 'C. Alcarva, “Plasticity in the cerebellum: What molecular mechanisms are
behind physiological learning,” Institute of Science and Technology Austria, 2023.'
ista: 'Alcarva C. 2023. Plasticity in the cerebellum: What molecular mechanisms
are behind physiological learning. Institute of Science and Technology Austria.'
mla: 'Alcarva, Catarina. Plasticity in the Cerebellum: What Molecular Mechanisms
Are behind Physiological Learning. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12809.'
short: 'C. Alcarva, Plasticity in the Cerebellum: What Molecular Mechanisms Are
behind Physiological Learning, Institute of Science and Technology Austria, 2023.'
date_created: 2023-04-06T07:54:09Z
date_published: 2023-04-06T00:00:00Z
date_updated: 2023-04-26T12:16:56Z
day: '06'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RySh
doi: 10.15479/at:ista:12809
file:
- access_level: closed
checksum: 35b5997d2b0acb461f9d33d073da0df5
content_type: application/pdf
creator: cchlebak
date_created: 2023-04-07T06:16:06Z
date_updated: 2023-04-07T06:16:06Z
embargo: 2024-04-07
embargo_to: open_access
file_id: '12814'
file_name: Thesis_CatarinaAlcarva_final pdfA.pdf
file_size: 9881969
relation: main_file
- access_level: closed
checksum: 81198f63c294890f6d58e8b29782efdc
content_type: application/pdf
creator: cchlebak
date_created: 2023-04-07T06:17:11Z
date_updated: 2023-04-07T06:17:11Z
file_id: '12815'
file_name: Thesis_CatarinaAlcarva_final_for printing.pdf
file_size: 44201583
relation: source_file
- access_level: closed
checksum: 0317bf7f457bb585f99d453ffa69eb53
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: cchlebak
date_created: 2023-04-07T06:18:05Z
date_updated: 2023-04-07T06:18:05Z
file_id: '12816'
file_name: Thesis_CatarinaAlcarva_final.docx
file_size: 84731244
relation: source_file
file_date_updated: 2023-04-07T06:18:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa_version: Published Version
page: '115'
project:
- _id: 267DFB90-B435-11E9-9278-68D0E5697425
name: 'Plasticity in the cerebellum: Which molecular mechanisms are behind physiological
learning?'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: 'Plasticity in the cerebellum: What molecular mechanisms are behind physiological
learning'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12668'
abstract:
- lang: eng
text: "Background: Plant and animal embryogenesis have conserved and distinct features.
Cell fate transitions occur during embryogenesis in both plants and animals. The
epigenomic processes regulating plant embryogenesis remain largely elusive.\r\n\r\nResults:
Here, we elucidate chromatin and transcriptomic dynamics during embryogenesis
of the most cultivated crop, hexaploid wheat. Time-series analysis reveals stage-specific
and proximal–distal distinct chromatin accessibility and dynamics concordant with
transcriptome changes. Following fertilization, the remodeling kinetics of H3K4me3,
H3K27ac, and H3K27me3 differ from that in mammals, highlighting considerable species-specific
epigenomic dynamics during zygotic genome activation. Polycomb repressive complex
2 (PRC2)-mediated H3K27me3 deposition is important for embryo establishment. Later
H3K27ac, H3K27me3, and chromatin accessibility undergo dramatic remodeling to
establish a permissive chromatin environment facilitating the access of transcription
factors to cis-elements for fate patterning. Embryonic maturation is characterized
by increasing H3K27me3 and decreasing chromatin accessibility, which likely participates
in restricting totipotency while preventing extensive organogenesis. Finally,
epigenomic signatures are correlated with biased expression among homeolog triads
and divergent expression after polyploidization, revealing an epigenomic contributor
to subgenome diversification in an allohexaploid genome.\r\n\r\nConclusions: Collectively,
we present an invaluable resource for comparative and mechanistic analysis of
the epigenomic regulation of crop embryogenesis."
article_number: '7'
article_processing_charge: No
article_type: original
author:
- first_name: Long
full_name: Zhao, Long
last_name: Zhao
- first_name: Yiman
full_name: Yang, Yiman
last_name: Yang
- first_name: Jinchao
full_name: Chen, Jinchao
last_name: Chen
- first_name: Xuelei
full_name: Lin, Xuelei
last_name: Lin
- first_name: Hao
full_name: Zhang, Hao
last_name: Zhang
- first_name: Hao
full_name: Wang, Hao
last_name: Wang
- first_name: Hongzhe
full_name: Wang, Hongzhe
last_name: Wang
- first_name: Xiaomin
full_name: Bie, Xiaomin
last_name: Bie
- first_name: Jiafu
full_name: Jiang, Jiafu
last_name: Jiang
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Xiangdong
full_name: Fu, Xiangdong
last_name: Fu
- first_name: Xiansheng
full_name: Zhang, Xiansheng
last_name: Zhang
- first_name: Zhuo
full_name: Du, Zhuo
last_name: Du
- first_name: Jun
full_name: Xiao, Jun
last_name: Xiao
citation:
ama: Zhao L, Yang Y, Chen J, et al. Dynamic chromatin regulatory programs during
embryogenesis of hexaploid wheat. Genome Biology. 2023;24. doi:10.1186/s13059-022-02844-2
apa: Zhao, L., Yang, Y., Chen, J., Lin, X., Zhang, H., Wang, H., … Xiao, J. (2023).
Dynamic chromatin regulatory programs during embryogenesis of hexaploid wheat.
Genome Biology. Springer Nature. https://doi.org/10.1186/s13059-022-02844-2
chicago: Zhao, Long, Yiman Yang, Jinchao Chen, Xuelei Lin, Hao Zhang, Hao Wang,
Hongzhe Wang, et al. “Dynamic Chromatin Regulatory Programs during Embryogenesis
of Hexaploid Wheat.” Genome Biology. Springer Nature, 2023. https://doi.org/10.1186/s13059-022-02844-2.
ieee: L. Zhao et al., “Dynamic chromatin regulatory programs during embryogenesis
of hexaploid wheat,” Genome Biology, vol. 24. Springer Nature, 2023.
ista: Zhao L, Yang Y, Chen J, Lin X, Zhang H, Wang H, Wang H, Bie X, Jiang J, Feng
X, Fu X, Zhang X, Du Z, Xiao J. 2023. Dynamic chromatin regulatory programs during
embryogenesis of hexaploid wheat. Genome Biology. 24, 7.
mla: Zhao, Long, et al. “Dynamic Chromatin Regulatory Programs during Embryogenesis
of Hexaploid Wheat.” Genome Biology, vol. 24, 7, Springer Nature, 2023,
doi:10.1186/s13059-022-02844-2.
short: L. Zhao, Y. Yang, J. Chen, X. Lin, H. Zhang, H. Wang, H. Wang, X. Bie, J.
Jiang, X. Feng, X. Fu, X. Zhang, Z. Du, J. Xiao, Genome Biology 24 (2023).
date_created: 2023-02-23T09:13:49Z
date_published: 2023-01-13T00:00:00Z
date_updated: 2023-05-08T10:52:49Z
day: '13'
department:
- _id: XiFe
doi: 10.1186/s13059-022-02844-2
extern: '1'
external_id:
pmid:
- '36639687'
intvolume: ' 24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1186/s13059-022-02844-2
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
issn:
- 1474-760X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic chromatin regulatory programs during embryogenesis of hexaploid wheat
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2023'
...
---
_id: '12920'
abstract:
- lang: eng
text: The multicomponent approach allows to incorporate several functionalities
into a single covalent organic framework (COF) and consequently allows the construction
of bifunctional materials for cooperative catalysis. The well-defined structure
of such multicomponent COFs is furthermore ideally suited for structure-activity
relationship studies. We report a series of multicomponent COFs that contain acridine-
and 2,2’-bipyridine linkers connected through 1,3,5-benzenetrialdehyde derivatives.
The acridine motif is responsible for broad light absorption, while the bipyridine
unit enables complexation of nickel catalysts. These features enable the usage
of the framework materials as catalysts for light-mediated carbon−heteroatom cross-couplings.
Variation of the node units shows that the catalytic activity correlates to the
keto-enamine tautomer isomerism. This allows switching between high charge-carrier
mobility and persistent, localized charge-separated species depending on the nodes,
a tool to tailor the materials for specific reactions. Moreover, nickel-loaded
COFs are recyclable and catalyze cross-couplings even using red light irradiation.
article_number: e202202967
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Traxler, Michael
last_name: Traxler
- first_name: Susanne
full_name: Reischauer, Susanne
last_name: Reischauer
- first_name: Sarah
full_name: Vogl, Sarah
last_name: Vogl
- first_name: Jérôme
full_name: Roeser, Jérôme
last_name: Roeser
- first_name: Jabor
full_name: Rabeah, Jabor
last_name: Rabeah
- first_name: Christopher
full_name: Penschke, Christopher
last_name: Penschke
- first_name: Peter
full_name: Saalfrank, Peter
last_name: Saalfrank
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Arne
full_name: Thomas, Arne
last_name: Thomas
citation:
ama: Traxler M, Reischauer S, Vogl S, et al. Programmable photocatalytic activity
of multicomponent covalent organic frameworks used as metallaphotocatalysts. Chemistry
– A European Journal. 2023;29(4). doi:10.1002/chem.202202967
apa: Traxler, M., Reischauer, S., Vogl, S., Roeser, J., Rabeah, J., Penschke, C.,
… Thomas, A. (2023). Programmable photocatalytic activity of multicomponent covalent
organic frameworks used as metallaphotocatalysts. Chemistry – A European Journal.
Wiley. https://doi.org/10.1002/chem.202202967
chicago: Traxler, Michael, Susanne Reischauer, Sarah Vogl, Jérôme Roeser, Jabor
Rabeah, Christopher Penschke, Peter Saalfrank, Bartholomäus Pieber, and Arne Thomas.
“Programmable Photocatalytic Activity of Multicomponent Covalent Organic Frameworks
Used as Metallaphotocatalysts.” Chemistry – A European Journal. Wiley,
2023. https://doi.org/10.1002/chem.202202967.
ieee: M. Traxler et al., “Programmable photocatalytic activity of multicomponent
covalent organic frameworks used as metallaphotocatalysts,” Chemistry – A European
Journal, vol. 29, no. 4. Wiley, 2023.
ista: Traxler M, Reischauer S, Vogl S, Roeser J, Rabeah J, Penschke C, Saalfrank
P, Pieber B, Thomas A. 2023. Programmable photocatalytic activity of multicomponent
covalent organic frameworks used as metallaphotocatalysts. Chemistry – A European
Journal. 29(4), e202202967.
mla: Traxler, Michael, et al. “Programmable Photocatalytic Activity of Multicomponent
Covalent Organic Frameworks Used as Metallaphotocatalysts.” Chemistry – A European
Journal, vol. 29, no. 4, e202202967, Wiley, 2023, doi:10.1002/chem.202202967.
short: M. Traxler, S. Reischauer, S. Vogl, J. Roeser, J. Rabeah, C. Penschke, P.
Saalfrank, B. Pieber, A. Thomas, Chemistry – A European Journal 29 (2023).
date_created: 2023-05-08T08:25:34Z
date_published: 2023-01-18T00:00:00Z
date_updated: 2023-05-15T08:39:24Z
day: '18'
doi: 10.1002/chem.202202967
extern: '1'
intvolume: ' 29'
issue: '4'
keyword:
- General Chemistry
- Catalysis
- Organic Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/chem.202202967
month: '01'
oa: 1
oa_version: Published Version
publication: Chemistry – A European Journal
publication_identifier:
eissn:
- 1521-3765
issn:
- 0947-6539
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Programmable photocatalytic activity of multicomponent covalent organic frameworks
used as metallaphotocatalysts
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2023'
...
---
_id: '12921'
abstract:
- lang: eng
text: Visible-light photocatalysis provides numerous useful methodologies for synthetic
organic chemistry. However, the mechanisms of these reactions are often not fully
understood. Common mechanistic experiments mainly aim to characterize excited
state properties of photocatalysts and their interaction with other species. Recently,
in situ reaction monitoring using dedicated techniques was shown to be well-suited
for the identification of intermediates and to obtain kinetic insights, thereby
providing more holistic pictures of the reactions of interest. This minireview
surveys these technologies and discusses selected examples where reaction monitoring
was used to elucidate the mechanism of photocatalytic reactions.
article_number: e202201583
article_processing_charge: No
article_type: original
author:
- first_name: Amiera
full_name: Madani, Amiera
last_name: Madani
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Madani A, Pieber B. In situ reaction monitoring in photocatalytic organic synthesis.
ChemCatChem. 2023;15(7). doi:10.1002/cctc.202201583
apa: Madani, A., & Pieber, B. (2023). In situ reaction monitoring in photocatalytic
organic synthesis. ChemCatChem. Wiley. https://doi.org/10.1002/cctc.202201583
chicago: Madani, Amiera, and Bartholomäus Pieber. “In Situ Reaction Monitoring in
Photocatalytic Organic Synthesis.” ChemCatChem. Wiley, 2023. https://doi.org/10.1002/cctc.202201583.
ieee: A. Madani and B. Pieber, “In situ reaction monitoring in photocatalytic organic
synthesis,” ChemCatChem, vol. 15, no. 7. Wiley, 2023.
ista: Madani A, Pieber B. 2023. In situ reaction monitoring in photocatalytic organic
synthesis. ChemCatChem. 15(7), e202201583.
mla: Madani, Amiera, and Bartholomäus Pieber. “In Situ Reaction Monitoring in Photocatalytic
Organic Synthesis.” ChemCatChem, vol. 15, no. 7, e202201583, Wiley, 2023,
doi:10.1002/cctc.202201583.
short: A. Madani, B. Pieber, ChemCatChem 15 (2023).
date_created: 2023-05-08T08:25:55Z
date_published: 2023-04-06T00:00:00Z
date_updated: 2023-05-15T08:35:48Z
day: '06'
doi: 10.1002/cctc.202201583
extern: '1'
intvolume: ' 15'
issue: '7'
keyword:
- Inorganic Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Catalysis
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/cctc.202201583
month: '04'
oa: 1
oa_version: Published Version
publication: ChemCatChem
publication_identifier:
eissn:
- 1867-3899
issn:
- 1867-3880
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: In situ reaction monitoring in photocatalytic organic synthesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...