--- _id: '2942' abstract: - lang: eng text: Interface theories provide a formal framework for component-based development of software and hardware which supports the incremental design of systems and the independent implementability of components. These capabilities are ensured through mathematical properties of the parallel composition operator and the refinement relation for components. More recently, a conjunction operation was added to interface theories in order to provide support for handling multiple viewpoints, requirements engineering, and component reuse. Unfortunately, the conjunction operator does not allow independent implementability in general. In this paper, we study conditions that need to be imposed on interface models in order to enforce independent implementability with respect to conjunction. We focus on multiple viewpoint specifications and propose a new compatibility criterion between two interfaces, which we call orthogonality. We show that orthogonal interfaces can be refined separately, while preserving both orthogonality and composability with other interfaces. We illustrate the independent implementability of different viewpoints with a FIFO buffer example. acknowledgement: ERC Advanced Grant QUAREM (Quantitative Reactive Modeling), FWF National Research Network RISE (Rigorous Systems Engineering) alternative_title: - LNCS author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Dejan full_name: Nickovic, Dejan id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87 last_name: Nickovic citation: ama: 'Henzinger TA, Nickovic D. Independent implementability of viewpoints. In: Conference Proceedings Monterey Workshop 2012. Vol 7539. Springer; 2012:380-395. doi:10.1007/978-3-642-34059-8_20' apa: 'Henzinger, T. A., & Nickovic, D. (2012). Independent implementability of viewpoints. In Conference proceedings Monterey Workshop 2012 (Vol. 7539, pp. 380–395). Oxford, UK: Springer. https://doi.org/10.1007/978-3-642-34059-8_20' chicago: Henzinger, Thomas A, and Dejan Nickovic. “Independent Implementability of Viewpoints.” In Conference Proceedings Monterey Workshop 2012, 7539:380–95. Springer, 2012. https://doi.org/10.1007/978-3-642-34059-8_20. ieee: T. A. Henzinger and D. Nickovic, “Independent implementability of viewpoints,” in Conference proceedings Monterey Workshop 2012, Oxford, UK, 2012, vol. 7539, pp. 380–395. ista: Henzinger TA, Nickovic D. 2012. Independent implementability of viewpoints. Conference proceedings Monterey Workshop 2012. Monterey Workshop 2012, LNCS, vol. 7539, 380–395. mla: Henzinger, Thomas A., and Dejan Nickovic. “Independent Implementability of Viewpoints.” Conference Proceedings Monterey Workshop 2012, vol. 7539, Springer, 2012, pp. 380–95, doi:10.1007/978-3-642-34059-8_20. short: T.A. Henzinger, D. Nickovic, in:, Conference Proceedings Monterey Workshop 2012, Springer, 2012, pp. 380–395. conference: end_date: 2012-03-21 location: Oxford, UK name: Monterey Workshop 2012 start_date: 2012-03-19 date_created: 2018-12-11T12:00:28Z date_published: 2012-09-16T00:00:00Z date_updated: 2021-01-12T07:39:56Z day: '16' department: - _id: ToHe doi: 10.1007/978-3-642-34059-8_20 ec_funded: 1 intvolume: ' 7539' language: - iso: eng month: '09' oa_version: None page: 380 - 395 project: - _id: 25EE3708-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '267989' name: Quantitative Reactive Modeling - _id: 25832EC2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: S 11407_N23 name: Rigorous Systems Engineering publication: ' Conference proceedings Monterey Workshop 2012' publication_status: published publisher: Springer publist_id: '3791' quality_controlled: '1' scopus_import: 1 status: public title: Independent implementability of viewpoints type: conference user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 7539 year: '2012' ... --- _id: '2943' abstract: - lang: eng text: We examine whether the Escherichia coli chromosome is folded into a self-adherent nucleoprotein complex, or alternately is a confined but otherwise unconstrained self-avoiding polymer. We address this through in vivo visualization, using an inducible GFP fusion to the nucleoid-associated protein Fis to non-specifically decorate the entire chromosome. For a range of different growth conditions, the chromosome is a compact structure that does not fill the volume of the cell, and which moves from the new pole to the cell centre. During rapid growth, chromosome segregation occurs well before cell division, with daughter chromosomes coupled by a thin inter-daughter filament before complete segregation, whereas during slow growth chromosomes stay adjacent until cell division occurs. Image correlation analysis indicates that sub-nucleoid structure is stable on a 1min timescale, comparable to the timescale for redistribution time measured for GFP-Fis after photobleaching. Optical deconvolution and writhe calculation analysis indicate that the nucleoid has a large-scale coiled organization rather than being an amorphous mass. Our observations are consistent with the chromosome having a self-adherent filament organization. acknowledgement: We thank Professor Philippe Cluzel and Mr Lance Min for providing advice and materials. Jeannette Chau provided technical support. Work at NU was supported by NSF Grants DMR-0715099, MCB-1022117, DMR-1206868, DMR-0520513 and DMR-1121262 (NU-MRSEC), by NIH-NCI Grant U54CA143869-01 (NU-PS-OC) and by the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust. Work at UCLA was supported by NIH Grant GM038509. author: - first_name: Nastaran full_name: Hadizadeh Yazdi, Nastaran last_name: Hadizadeh Yazdi - first_name: Calin C full_name: Guet, Calin C id: 47F8433E-F248-11E8-B48F-1D18A9856A87 last_name: Guet orcid: 0000-0001-6220-2052 - first_name: Reid full_name: Johnson, Reid last_name: Johnson - first_name: John full_name: Marko, John last_name: Marko citation: ama: Hadizadeh Yazdi N, Guet CC, Johnson R, Marko J. Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions. Molecular Microbiology. 2012;86(6):1318-1333. doi:10.1111/mmi.12071 apa: Hadizadeh Yazdi, N., Guet, C. C., Johnson, R., & Marko, J. (2012). Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions. Molecular Microbiology. Wiley-Blackwell. https://doi.org/10.1111/mmi.12071 chicago: Hadizadeh Yazdi, Nastaran, Calin C Guet, Reid Johnson, and John Marko. “Variation of the Folding and Dynamics of the Escherichia Coli Chromosome with Growth Conditions.” Molecular Microbiology. Wiley-Blackwell, 2012. https://doi.org/10.1111/mmi.12071. ieee: N. Hadizadeh Yazdi, C. C. Guet, R. Johnson, and J. Marko, “Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions,” Molecular Microbiology, vol. 86, no. 6. Wiley-Blackwell, pp. 1318–1333, 2012. ista: Hadizadeh Yazdi N, Guet CC, Johnson R, Marko J. 2012. Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions. Molecular Microbiology. 86(6), 1318–1333. mla: Hadizadeh Yazdi, Nastaran, et al. “Variation of the Folding and Dynamics of the Escherichia Coli Chromosome with Growth Conditions.” Molecular Microbiology, vol. 86, no. 6, Wiley-Blackwell, 2012, pp. 1318–33, doi:10.1111/mmi.12071. short: N. Hadizadeh Yazdi, C.C. Guet, R. Johnson, J. Marko, Molecular Microbiology 86 (2012) 1318–1333. date_created: 2018-12-11T12:00:28Z date_published: 2012-11-09T00:00:00Z date_updated: 2021-01-12T07:39:56Z day: '09' department: - _id: CaGu doi: 10.1111/mmi.12071 intvolume: ' 86' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: http://europepmc.org/articles/pmc3524407 month: '11' oa: 1 oa_version: Submitted Version page: 1318 - 1333 publication: Molecular Microbiology publication_status: published publisher: Wiley-Blackwell publist_id: '3790' quality_controlled: '1' scopus_import: 1 status: public title: Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2012' ... --- _id: '2941' author: - first_name: Nikolai full_name: Dolbilin, Nikolai last_name: Dolbilin - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Oleg full_name: Musin, Oleg last_name: Musin citation: ama: Dolbilin N, Edelsbrunner H, Musin O. On the optimality of functionals over triangulations of Delaunay sets. Russian Mathematical Surveys. 2012;67(4):781-783. doi:10.1070/RM2012v067n04ABEH004807 apa: Dolbilin, N., Edelsbrunner, H., & Musin, O. (2012). On the optimality of functionals over triangulations of Delaunay sets. Russian Mathematical Surveys. IOP Publishing. https://doi.org/10.1070/RM2012v067n04ABEH004807 chicago: Dolbilin, Nikolai, Herbert Edelsbrunner, and Oleg Musin. “On the Optimality of Functionals over Triangulations of Delaunay Sets.” Russian Mathematical Surveys. IOP Publishing, 2012. https://doi.org/10.1070/RM2012v067n04ABEH004807. ieee: N. Dolbilin, H. Edelsbrunner, and O. Musin, “On the optimality of functionals over triangulations of Delaunay sets,” Russian Mathematical Surveys, vol. 67, no. 4. IOP Publishing, pp. 781–783, 2012. ista: Dolbilin N, Edelsbrunner H, Musin O. 2012. On the optimality of functionals over triangulations of Delaunay sets. Russian Mathematical Surveys. 67(4), 781–783. mla: Dolbilin, Nikolai, et al. “On the Optimality of Functionals over Triangulations of Delaunay Sets.” Russian Mathematical Surveys, vol. 67, no. 4, IOP Publishing, 2012, pp. 781–83, doi:10.1070/RM2012v067n04ABEH004807. short: N. Dolbilin, H. Edelsbrunner, O. Musin, Russian Mathematical Surveys 67 (2012) 781–783. date_created: 2018-12-11T12:00:28Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:39:55Z day: '01' ddc: - '510' department: - _id: HeEd doi: 10.1070/RM2012v067n04ABEH004807 file: - access_level: open_access checksum: 389a5ae53d6347de36c3468034f2821d content_type: application/pdf creator: system date_created: 2018-12-12T10:16:49Z date_updated: 2020-07-14T12:45:55Z file_id: '5239' file_name: IST-2013-132-v1+1_2012-J-04-Functional-E.pdf file_size: 253816 relation: main_file file_date_updated: 2020-07-14T12:45:55Z has_accepted_license: '1' intvolume: ' 67' issue: '4' language: - iso: eng month: '11' oa: 1 oa_version: Submitted Version page: 781 - 783 publication: Russian Mathematical Surveys publication_status: published publisher: IOP Publishing publist_id: '3792' pubrep_id: '132' quality_controlled: '1' scopus_import: 1 status: public title: On the optimality of functionals over triangulations of Delaunay sets type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 67 year: '2012' ... --- _id: '2946' abstract: - lang: eng text: MicroRNAs (miRNAs) are small noncoding RNAs that function in literally all cellular processes. miRNAs interact with Argonaute (Ago) proteins and guide them to specific target sites located in the 3′-untranslated region (3′-UTR) of target mRNAs leading to translational repression and deadenylation-induced mRNA degradation. Most miRNAs are processed from hairpin-structured precursors by the consecutive action of the RNase III enzymes Drosha and Dicer. However, processing of miR-451 is Dicer independent and cleavage is mediated by the endonuclease Ago2. Here we have characterized miR-451 sequence and structure requirements for processing as well as sorting of miRNAs into different Ago proteins. Pre-miR-451 appears to be optimized for Ago2 cleavage and changes result in reduced processing. In addition, we show that the mature miR-451 only associates with Ago2 suggesting that mature miRNAs are not exchanged between different members of the Ago protein family. Based on cloning and deep sequencing of endogenous miRNAs associated with Ago1-3, we do not find evidence for miRNA sorting in human cells. However, Ago identity appears to influence the length of some miRNAs, while others remain unaffected. acknowledgement: "Deutsche Forschungsgemeinschaft (DFG) (SFB 960 and FOR855); European Research Council (ERC grant ‘sRNAs’); European Union (FP7 project ‘ONCOMIRs’); German Bundesministerium für Bildung und Forschung (BMBF, NGFN+, FKZ PIM-01GS0804-5); Bavarian Genome Research Network (BayGene to G.M.); The Netherlands Organization for Scientific Research (NWO, VIDI grant to E.B.). Funding for open access charge: DFG via the open access publishing program. \r\n\r\nWe thank Sigrun Ammon and Corinna Friederich for technical assistance and Sebastian Petri and Daniel Schraivogel for helpful discussions." author: - first_name: Anne full_name: Dueck, Anne last_name: Dueck - first_name: Christian full_name: Ziegler, Christian last_name: Ziegler - first_name: Alexander full_name: Eichner, Alexander id: 4DFA52AE-F248-11E8-B48F-1D18A9856A87 last_name: Eichner - first_name: Eugène full_name: Berezikov, Eugène last_name: Berezikov - first_name: Gunter full_name: Meister, Gunter last_name: Meister citation: ama: Dueck A, Ziegler C, Eichner A, Berezikov E, Meister G. MicroRNAs associated with the different human Argonaute proteins. Nucleic Acids Research. 2012;40(19):9850-9862. doi:10.1093/nar/gks705 apa: Dueck, A., Ziegler, C., Eichner, A., Berezikov, E., & Meister, G. (2012). MicroRNAs associated with the different human Argonaute proteins. Nucleic Acids Research. Oxford University Press. https://doi.org/10.1093/nar/gks705 chicago: Dueck, Anne, Christian Ziegler, Alexander Eichner, Eugène Berezikov, and Gunter Meister. “MicroRNAs Associated with the Different Human Argonaute Proteins.” Nucleic Acids Research. Oxford University Press, 2012. https://doi.org/10.1093/nar/gks705. ieee: A. Dueck, C. Ziegler, A. Eichner, E. Berezikov, and G. Meister, “MicroRNAs associated with the different human Argonaute proteins,” Nucleic Acids Research, vol. 40, no. 19. Oxford University Press, pp. 9850–9862, 2012. ista: Dueck A, Ziegler C, Eichner A, Berezikov E, Meister G. 2012. MicroRNAs associated with the different human Argonaute proteins. Nucleic Acids Research. 40(19), 9850–9862. mla: Dueck, Anne, et al. “MicroRNAs Associated with the Different Human Argonaute Proteins.” Nucleic Acids Research, vol. 40, no. 19, Oxford University Press, 2012, pp. 9850–62, doi:10.1093/nar/gks705. short: A. Dueck, C. Ziegler, A. Eichner, E. Berezikov, G. Meister, Nucleic Acids Research 40 (2012) 9850–9862. date_created: 2018-12-11T12:00:29Z date_published: 2012-10-01T00:00:00Z date_updated: 2021-01-12T07:39:57Z day: '01' ddc: - '570' department: - _id: MiSi doi: 10.1093/nar/gks705 file: - access_level: open_access checksum: 1bb8d1ff894014b481657a21083c941c content_type: application/pdf creator: system date_created: 2018-12-12T10:13:12Z date_updated: 2020-07-14T12:45:55Z file_id: '4993' file_name: IST-2015-383-v1+1_Nucl._Acids_Res.-2012-Dueck-9850-62.pdf file_size: 8126936 relation: main_file file_date_updated: 2020-07-14T12:45:55Z has_accepted_license: '1' intvolume: ' 40' issue: '19' language: - iso: eng license: https://creativecommons.org/licenses/by-nc/4.0/ month: '10' oa: 1 oa_version: Published Version page: 9850 - 9862 publication: Nucleic Acids Research publication_status: published publisher: Oxford University Press publist_id: '3786' pubrep_id: '383' quality_controlled: '1' scopus_import: 1 status: public title: MicroRNAs associated with the different human Argonaute proteins tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 40 year: '2012' ... --- _id: '2947' abstract: - lang: eng text: We introduce games with probabilistic uncertainty, a model for controller synthesis in which the controller observes the state through imprecise sensors that provide correct information about the current state with a fixed probability. That is, in each step, the sensors return an observed state, and given the observed state, there is a probability distribution (due to the estimation error) over the actual current state. The controller must base its decision on the observed state (rather than the actual current state, which it does not know). On the other hand, we assume that the environment can perfectly observe the current state. We show that controller synthesis for qualitative ω-regular objectives in our model can be reduced in polynomial time to standard partial-observation stochastic games, and vice-versa. As a consequence we establish the precise decidability frontier for the new class of games, and establish optimal complexity results for all the decidable problems. acknowledgement: 'The research was supported by Austrian Science Fund (FWF) Grant No P 23499-N23 on Modern Graph Algorithmic Techniques in Formal Verification, FWF NFN Grant No S11407-N23 (RiSE), ERC Start grant (279307: Graph Games), and Microsoft faculty fellows award.' alternative_title: - LNCS author: - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Martin full_name: Chmelik, Martin id: 3624234E-F248-11E8-B48F-1D18A9856A87 last_name: Chmelik - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar citation: ama: 'Chatterjee K, Chmelik M, Majumdar R. Equivalence of games with probabilistic uncertainty and partial observation games. In: Vol 7561. Springer; 2012:385-399. doi:10.1007/978-3-642-33386-6_30' apa: 'Chatterjee, K., Chmelik, M., & Majumdar, R. (2012). Equivalence of games with probabilistic uncertainty and partial observation games (Vol. 7561, pp. 385–399). Presented at the ATVA: Automated Technology for Verification and Analysis, Thiruvananthapuram, India: Springer. https://doi.org/10.1007/978-3-642-33386-6_30' chicago: Chatterjee, Krishnendu, Martin Chmelik, and Ritankar Majumdar. “Equivalence of Games with Probabilistic Uncertainty and Partial Observation Games,” 7561:385–99. Springer, 2012. https://doi.org/10.1007/978-3-642-33386-6_30. ieee: 'K. Chatterjee, M. Chmelik, and R. Majumdar, “Equivalence of games with probabilistic uncertainty and partial observation games,” presented at the ATVA: Automated Technology for Verification and Analysis, Thiruvananthapuram, India, 2012, vol. 7561, pp. 385–399.' ista: 'Chatterjee K, Chmelik M, Majumdar R. 2012. Equivalence of games with probabilistic uncertainty and partial observation games. ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 7561, 385–399.' mla: Chatterjee, Krishnendu, et al. Equivalence of Games with Probabilistic Uncertainty and Partial Observation Games. Vol. 7561, Springer, 2012, pp. 385–99, doi:10.1007/978-3-642-33386-6_30. short: K. Chatterjee, M. Chmelik, R. Majumdar, in:, Springer, 2012, pp. 385–399. conference: end_date: 2012-10-06 location: Thiruvananthapuram, India name: ' ATVA: Automated Technology for Verification and Analysis' start_date: 2012-10-03 date_created: 2018-12-11T12:00:29Z date_published: 2012-06-01T00:00:00Z date_updated: 2021-01-12T07:39:58Z day: '01' department: - _id: KrCh doi: 10.1007/978-3-642-33386-6_30 ec_funded: 1 intvolume: ' 7561' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1202.4140 month: '06' oa: 1 oa_version: Preprint page: 385 - 399 project: - _id: 2584A770-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: P 23499-N23 name: Modern Graph Algorithmic Techniques in Formal Verification - _id: 25832EC2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: S 11407_N23 name: Rigorous Systems Engineering - _id: 2581B60A-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '279307' name: 'Quantitative Graph Games: Theory and Applications' - _id: 2587B514-B435-11E9-9278-68D0E5697425 name: Microsoft Research Faculty Fellowship publication_status: published publisher: Springer publist_id: '3785' quality_controlled: '1' scopus_import: 1 status: public title: Equivalence of games with probabilistic uncertainty and partial observation games type: conference user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 7561 year: '2012' ... --- _id: '2945' abstract: - lang: eng text: In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes, into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal interaction with lymphocytes. This continuous trafficking of immune cells into and out of lymph nodes is essential for immune surveillance of foreign invaders. In this article, we review our current understanding of the functions of high endothelial venules (HEVs), stroma and lymphatics in the entry, positioning and exit of immune cells in lymph nodes during homeostasis, and we highlight the unexpected role of dendritic cells in the control of lymphocyte homing through HEVs. acknowledgement: We thank M. Sixt and A. Peixoto for helpful comments on the manuscript. Work in the laboratory of J.-P.G. is supported by grants from Fondation ARC pour la Recherche sur le Cancer, Agence Nationale de la Recherche (ANR), Institut National du Cancer (INCA), Fondation RITC and Région Midi-Pyrénées. Research by R.F. is supported by Deutsche Forschungsgemeinschaft (DFG) grants SFB621-A1, SFB738-B5, SFB587-B3, SFB900-B1 and KFO 250-FO 334/2-1. We regret that, owing to space limitations, we could not always quote the work of colleagues who have contributed to the field. author: - first_name: Jean full_name: Girard, Jean last_name: Girard - first_name: Christine full_name: Moussion, Christine id: 3356F664-F248-11E8-B48F-1D18A9856A87 last_name: Moussion - first_name: Reinhold full_name: Förster, Reinhold last_name: Förster citation: ama: Girard J, Moussion C, Förster R. HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nature Reviews Immunology. 2012;12(11):762-773. doi:10.1038/nri3298 apa: Girard, J., Moussion, C., & Förster, R. (2012). HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nature Reviews Immunology. Nature Publishing Group. https://doi.org/10.1038/nri3298 chicago: Girard, Jean, Christine Moussion, and Reinhold Förster. “HEVs, Lymphatics and Homeostatic Immune Cell Trafficking in Lymph Nodes.” Nature Reviews Immunology. Nature Publishing Group, 2012. https://doi.org/10.1038/nri3298. ieee: J. Girard, C. Moussion, and R. Förster, “HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes,” Nature Reviews Immunology, vol. 12, no. 11. Nature Publishing Group, pp. 762–773, 2012. ista: Girard J, Moussion C, Förster R. 2012. HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nature Reviews Immunology. 12(11), 762–773. mla: Girard, Jean, et al. “HEVs, Lymphatics and Homeostatic Immune Cell Trafficking in Lymph Nodes.” Nature Reviews Immunology, vol. 12, no. 11, Nature Publishing Group, 2012, pp. 762–73, doi:10.1038/nri3298. short: J. Girard, C. Moussion, R. Förster, Nature Reviews Immunology 12 (2012) 762–773. date_created: 2018-12-11T12:00:29Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:39:57Z day: '01' department: - _id: MiSi doi: 10.1038/nri3298 intvolume: ' 12' issue: '11' language: - iso: eng month: '11' oa_version: None page: 762 - 773 publication: Nature Reviews Immunology publication_status: published publisher: Nature Publishing Group publist_id: '3787' quality_controlled: '1' scopus_import: 1 status: public title: HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2012' ... --- _id: '2949' author: - first_name: David full_name: Dupret, David last_name: Dupret - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Dupret D, Csicsvari JL. The medial entorhinal cortex keeps Up. Nature Neuroscience. 2012;15(11):1471-1472. doi:10.1038/nn.3245 apa: Dupret, D., & Csicsvari, J. L. (2012). The medial entorhinal cortex keeps Up. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3245 chicago: Dupret, David, and Jozsef L Csicsvari. “The Medial Entorhinal Cortex Keeps Up.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3245. ieee: D. Dupret and J. L. Csicsvari, “The medial entorhinal cortex keeps Up,” Nature Neuroscience, vol. 15, no. 11. Nature Publishing Group, pp. 1471–1472, 2012. ista: Dupret D, Csicsvari JL. 2012. The medial entorhinal cortex keeps Up. Nature Neuroscience. 15(11), 1471–1472. mla: Dupret, David, and Jozsef L. Csicsvari. “The Medial Entorhinal Cortex Keeps Up.” Nature Neuroscience, vol. 15, no. 11, Nature Publishing Group, 2012, pp. 1471–72, doi:10.1038/nn.3245. short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 15 (2012) 1471–1472. date_created: 2018-12-11T12:00:30Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:39:59Z day: '01' department: - _id: JoCs doi: 10.1038/nn.3245 intvolume: ' 15' issue: '11' language: - iso: eng main_file_link: - url: http://www.mrcbndu.ox.ac.uk/publications/medial-entorhinal-cortex-keeps month: '11' oa_version: None page: 1471 - 1472 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '3782' quality_controlled: '1' scopus_import: 1 status: public title: The medial entorhinal cortex keeps Up type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 15 year: '2012' ... --- _id: '2954' abstract: - lang: eng text: Spontaneous postsynaptic currents (PSCs) provide key information about the mechanisms of synaptic transmission and the activity modes of neuronal networks. However, detecting spontaneous PSCs in vitro and in vivo has been challenging, because of the small amplitude, the variable kinetics, and the undefined time of generation of these events. Here, we describe a, to our knowledge, new method for detecting spontaneous synaptic events by deconvolution, using a template that approximates the average time course of spontaneous PSCs. A recorded PSC trace is deconvolved from the template, resulting in a series of delta-like functions. The maxima of these delta-like events are reliably detected, revealing the precise onset times of the spontaneous PSCs. Among all detection methods, the deconvolution-based method has a unique temporal resolution, allowing the detection of individual events in high-frequency bursts. Furthermore, the deconvolution-based method has a high amplitude resolution, because deconvolution can substantially increase the signal/noise ratio. When tested against previously published methods using experimental data, the deconvolution-based method was superior for spontaneous PSCs recorded in vivo. Using the high-resolution deconvolution-based detection algorithm, we show that the frequency of spontaneous excitatory postsynaptic currents in dentate gyrus granule cells is 4.5 times higher in vivo than in vitro. acknowledgement: "This work was supported by the Deutsche Forschungsgemeinschaft (TR3/B10) and a European Research Council Advanced grant to P.J.\r\nWe thank H. Hu, S. J. Guzman, and C. Schmidt-Hieber for critically reading the manuscript, I. Koeva and F. Marr for technical support, and E. Kramberger for editorial assistance.\r\n" author: - first_name: Alejandro full_name: Pernia-Andrade, Alejandro id: 36963E98-F248-11E8-B48F-1D18A9856A87 last_name: Pernia-Andrade - first_name: Sarit full_name: Goswami, Sarit id: 3A578F32-F248-11E8-B48F-1D18A9856A87 last_name: Goswami - first_name: Yvonne full_name: Stickler, Yvonne id: 63B76600-E9CC-11E9-9B5F-82450873F7A1 last_name: Stickler - first_name: Ulrich full_name: Fröbe, Ulrich last_name: Fröbe - first_name: Alois full_name: Schlögl, Alois id: 45BF87EE-F248-11E8-B48F-1D18A9856A87 last_name: Schlögl orcid: 0000-0002-5621-8100 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal. 2012;103(7):1429-1439. doi:10.1016/j.bpj.2012.08.039 apa: Pernia-Andrade, A., Goswami, S., Stickler, Y., Fröbe, U., Schlögl, A., & Jonas, P. M. (2012). A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal. Biophysical. https://doi.org/10.1016/j.bpj.2012.08.039 chicago: Pernia-Andrade, Alejandro, Sarit Goswami, Yvonne Stickler, Ulrich Fröbe, Alois Schlögl, and Peter M Jonas. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” Biophysical Journal. Biophysical, 2012. https://doi.org/10.1016/j.bpj.2012.08.039. ieee: A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, and P. M. Jonas, “A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo,” Biophysical Journal, vol. 103, no. 7. Biophysical, pp. 1429–1439, 2012. ista: Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. 2012. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal. 103(7), 1429–1439. mla: Pernia-Andrade, Alejandro, et al. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” Biophysical Journal, vol. 103, no. 7, Biophysical, 2012, pp. 1429–39, doi:10.1016/j.bpj.2012.08.039. short: A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, P.M. Jonas, Biophysical Journal 103 (2012) 1429–1439. date_created: 2018-12-11T12:00:32Z date_published: 2012-10-03T00:00:00Z date_updated: 2021-01-12T07:40:01Z day: '03' department: - _id: PeJo - _id: ScienComp doi: 10.1016/j.bpj.2012.08.039 external_id: pmid: - '23062335' intvolume: ' 103' issue: '7' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471482/ month: '10' oa: 1 oa_version: Submitted Version page: 1429 - 1439 pmid: 1 project: - _id: 25BDE9A4-B435-11E9-9278-68D0E5697425 grant_number: SFB-TR3-TP10B name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen publication: Biophysical Journal publication_status: published publisher: Biophysical publist_id: '3774' quality_controlled: '1' scopus_import: 1 status: public title: A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 103 year: '2012' ... --- _id: '2950' abstract: - lang: eng text: Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms. acknowledged_ssus: - _id: SSU author: - first_name: Martin full_name: Behrndt, Martin id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87 last_name: Behrndt - first_name: Guillaume full_name: Salbreux, Guillaume last_name: Salbreux - first_name: Pedro full_name: Campinho, Pedro id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87 last_name: Campinho orcid: 0000-0002-8526-5416 - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Felix full_name: Oswald, Felix last_name: Oswald - first_name: Julia full_name: Roensch, Julia id: 4220E59C-F248-11E8-B48F-1D18A9856A87 last_name: Roensch - first_name: Stephan full_name: Grill, Stephan last_name: Grill - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading in zebrafish gastrulation. Science. 2012;338(6104):257-260. doi:10.1126/science.1224143 apa: Behrndt, M., Salbreux, G., Campinho, P., Hauschild, R., Oswald, F., Roensch, J., … Heisenberg, C.-P. J. (2012). Forces driving epithelial spreading in zebrafish gastrulation. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1224143 chicago: Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild, Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” Science. American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1224143. ieee: M. Behrndt et al., “Forces driving epithelial spreading in zebrafish gastrulation,” Science, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 257–260, 2012. ista: Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill S, Heisenberg C-PJ. 2012. Forces driving epithelial spreading in zebrafish gastrulation. Science. 338(6104), 257–260. mla: Behrndt, Martin, et al. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” Science, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 257–60, doi:10.1126/science.1224143. short: M. Behrndt, G. Salbreux, P. Campinho, R. Hauschild, F. Oswald, J. Roensch, S. Grill, C.-P.J. Heisenberg, Science 338 (2012) 257–260. date_created: 2018-12-11T12:00:30Z date_published: 2012-10-12T00:00:00Z date_updated: 2023-02-21T17:02:44Z day: '12' department: - _id: CaHe - _id: Bio doi: 10.1126/science.1224143 intvolume: ' 338' issue: '6104' language: - iso: eng month: '10' oa_version: None page: 257 - 260 project: - _id: 252ABD0A-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I 930-B20 name: Control of Epithelial Cell Layer Spreading in Zebrafish publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '3778' quality_controlled: '1' related_material: record: - id: '1403' relation: dissertation_contains status: public scopus_import: 1 status: public title: Forces driving epithelial spreading in zebrafish gastrulation type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 338 year: '2012' ... --- _id: '2951' abstract: - lang: eng text: Differential cell adhesion and cortex tension are thought to drive cell sorting by controlling cell-cell contact formation. Here, we show that cell adhesion and cortex tension have different mechanical functions in controlling progenitor cell-cell contact formation and sorting during zebrafish gastrulation. Cortex tension controls cell-cell contact expansion by modulating interfacial tension at the contact. By contrast, adhesion has little direct function in contact expansion, but instead is needed to mechanically couple the cortices of adhering cells at their contacts, allowing cortex tension to control contact expansion. The coupling function of adhesion is mediated by E-cadherin and limited by the mechanical anchoring of E-cadherin to the cortex. Thus, cell adhesion provides the mechanical scaffold for cell cortex tension to drive cell sorting during gastrulation. acknowledged_ssus: - _id: SSU author: - first_name: Jean-Léon full_name: Maître, Jean-Léon id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87 last_name: Maître orcid: 0000-0002-3688-1474 - first_name: Hélène full_name: Berthoumieux, Hélène last_name: Berthoumieux - first_name: Gabriel full_name: Krens, Gabriel id: 2B819732-F248-11E8-B48F-1D18A9856A87 last_name: Krens orcid: 0000-0003-4761-5996 - first_name: Guillaume full_name: Salbreux, Guillaume last_name: Salbreux - first_name: Frank full_name: Julicher, Frank last_name: Julicher - first_name: Ewa full_name: Paluch, Ewa last_name: Paluch - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Maître J-L, Berthoumieux H, Krens G, et al. Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science. 2012;338(6104):253-256. doi:10.1126/science.1225399 apa: Maître, J.-L., Berthoumieux, H., Krens, G., Salbreux, G., Julicher, F., Paluch, E., & Heisenberg, C.-P. J. (2012). Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1225399 chicago: Maître, Jean-Léon, Hélène Berthoumieux, Gabriel Krens, Guillaume Salbreux, Frank Julicher, Ewa Paluch, and Carl-Philipp J Heisenberg. “Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells.” Science. American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225399. ieee: J.-L. Maître et al., “Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells,” Science, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 253–256, 2012. ista: Maître J-L, Berthoumieux H, Krens G, Salbreux G, Julicher F, Paluch E, Heisenberg C-PJ. 2012. Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science. 338(6104), 253–256. mla: Maître, Jean-Léon, et al. “Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells.” Science, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 253–56, doi:10.1126/science.1225399. short: J.-L. Maître, H. Berthoumieux, G. Krens, G. Salbreux, F. Julicher, E. Paluch, C.-P.J. Heisenberg, Science 338 (2012) 253–256. date_created: 2018-12-11T12:00:31Z date_published: 2012-10-12T00:00:00Z date_updated: 2021-01-12T07:40:00Z day: '12' department: - _id: CaHe doi: 10.1126/science.1225399 intvolume: ' 338' issue: '6104' language: - iso: eng month: '10' oa_version: None page: 253 - 256 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '3777' quality_controlled: '1' scopus_import: 1 status: public title: Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 338 year: '2012' ... --- _id: '2952' abstract: - lang: eng text: Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and extension. Both collective cell migration and cell intercalation are thought to drive CE and are used to different degrees in various species as they elongate their body axis. Here, we provide an overview of CE as a general strategy for body axis elongation and discuss conserved and divergent mechanisms underlying CE among different species. acknowledgement: 'M.T. is supported by the UK Medical Research Council (MRC) and Royal Society and C.-P.H. by the Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Deutsche Forschungsgemeinschaft (DFG) and Institute of Science and Technology Austria. ' author: - first_name: Masazumi full_name: Tada, Masazumi last_name: Tada - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: Tada M, Heisenberg C-PJ. Convergent extension Using collective cell migration and cell intercalation to shape embryos. Development. 2012;139(21):3897-3904. doi:10.1242/dev.073007 apa: Tada, M., & Heisenberg, C.-P. J. (2012). Convergent extension Using collective cell migration and cell intercalation to shape embryos. Development. Company of Biologists. https://doi.org/10.1242/dev.073007 chicago: Tada, Masazumi, and Carl-Philipp J Heisenberg. “Convergent Extension Using Collective Cell Migration and Cell Intercalation to Shape Embryos.” Development. Company of Biologists, 2012. https://doi.org/10.1242/dev.073007. ieee: M. Tada and C.-P. J. Heisenberg, “Convergent extension Using collective cell migration and cell intercalation to shape embryos,” Development, vol. 139, no. 21. Company of Biologists, pp. 3897–3904, 2012. ista: Tada M, Heisenberg C-PJ. 2012. Convergent extension Using collective cell migration and cell intercalation to shape embryos. Development. 139(21), 3897–3904. mla: Tada, Masazumi, and Carl-Philipp J. Heisenberg. “Convergent Extension Using Collective Cell Migration and Cell Intercalation to Shape Embryos.” Development, vol. 139, no. 21, Company of Biologists, 2012, pp. 3897–904, doi:10.1242/dev.073007. short: M. Tada, C.-P.J. Heisenberg, Development 139 (2012) 3897–3904. date_created: 2018-12-11T12:00:31Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:40:00Z day: '01' department: - _id: CaHe doi: 10.1242/dev.073007 intvolume: ' 139' issue: '21' language: - iso: eng month: '11' oa_version: None page: 3897 - 3904 publication: Development publication_status: published publisher: Company of Biologists publist_id: '3776' quality_controlled: '1' scopus_import: 1 status: public title: Convergent extension Using collective cell migration and cell intercalation to shape embryos type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 139 year: '2012' ... --- _id: '2953' author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Reinhard full_name: Fässler, Reinhard last_name: Fässler citation: ama: Heisenberg C-PJ, Fässler R. Cell-cell adhesion and extracellular matrix diversity counts. Current Opinion in Cell Biology. 2012;24(5):559-561. doi:10.1016/j.ceb.2012.09.002 apa: Heisenberg, C.-P. J., & Fässler, R. (2012). Cell-cell adhesion and extracellular matrix diversity counts. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2012.09.002 chicago: Heisenberg, Carl-Philipp J, and Reinhard Fässler. “Cell-Cell Adhesion and Extracellular Matrix Diversity Counts.” Current Opinion in Cell Biology. Elsevier, 2012. https://doi.org/10.1016/j.ceb.2012.09.002. ieee: C.-P. J. Heisenberg and R. Fässler, “Cell-cell adhesion and extracellular matrix diversity counts,” Current Opinion in Cell Biology, vol. 24, no. 5. Elsevier, pp. 559–561, 2012. ista: Heisenberg C-PJ, Fässler R. 2012. Cell-cell adhesion and extracellular matrix diversity counts. Current Opinion in Cell Biology. 24(5), 559–561. mla: Heisenberg, Carl-Philipp J., and Reinhard Fässler. “Cell-Cell Adhesion and Extracellular Matrix Diversity Counts.” Current Opinion in Cell Biology, vol. 24, no. 5, Elsevier, 2012, pp. 559–61, doi:10.1016/j.ceb.2012.09.002. short: C.-P.J. Heisenberg, R. Fässler, Current Opinion in Cell Biology 24 (2012) 559–561. date_created: 2018-12-11T12:00:31Z date_published: 2012-10-01T00:00:00Z date_updated: 2021-01-12T07:40:01Z day: '01' department: - _id: CaHe doi: 10.1016/j.ceb.2012.09.002 intvolume: ' 24' issue: '5' language: - iso: eng month: '10' oa_version: None page: 559 - 561 publication: Current Opinion in Cell Biology publication_status: published publisher: Elsevier publist_id: '3773' quality_controlled: '1' scopus_import: 1 status: public title: Cell-cell adhesion and extracellular matrix diversity counts type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 24 year: '2012' ... --- _id: '2958' abstract: - lang: eng text: 'The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, instead, via firing rate modulation of spatially stable place cells. To address these two questions, the activity of hippocampal neurons was recorded in rats performing a conditional discrimination task on a modified T-maze in which the identity of a food reward guided behavior. When the rat was on the central arm of the maze, the firing rate of pyramidal cells changed depending on two independent factors: (1) the identity of the food reward given to the animal and (2) the previous location of the animal on the maze. Importantly, some pyramidal cells encoded information relative to both factors. This trial-type specific and retrospective coding did not interfere with the spatial representation of the maze: hippocampal cells had stable place fields and their theta-phase precession profiles were unaltered during the task, indicating that trial-related information was encoded via rate remapping. During error trials, encoding of both trial-related information and spatial location was impaired. Finally, we found that pyramidal cells also encode trial-related information via rate remapping during the continuous version of the rewarded alternation task without delays. These results suggest that hippocampal neurons can encode several task-related cognitive aspects via rate remapping.' acknowledgement: J.C. was supported by a MRC Intramural Programme Grant (U138197111) and a European Research Council Starter Grant (281511). K.A. held a Wellcome Trust PhD studentship and a Humboldt Research Fellowship for Postdoctoral Researchers. D.M.B. was supported by Wellcome Trust Senior Fellowships (074385 and 087736). author: - first_name: Kevin full_name: Allen, Kevin last_name: Allen - first_name: J Nick full_name: Rawlins, J Nick last_name: Rawlins - first_name: David full_name: Bannerman, David last_name: Bannerman - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. 2012;32(42):14752-14766. doi:10.1523/JNEUROSCI.6175-11.2012 apa: Allen, K., Rawlins, J. N., Bannerman, D., & Csicsvari, J. L. (2012). Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6175-11.2012 chicago: Allen, Kevin, J Nick Rawlins, David Bannerman, and Jozsef L Csicsvari. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through Rate Remapping.” Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.6175-11.2012. ieee: K. Allen, J. N. Rawlins, D. Bannerman, and J. L. Csicsvari, “Hippocampal place cells can encode multiple trial-dependent features through rate remapping,” Journal of Neuroscience, vol. 32, no. 42. Society for Neuroscience, pp. 14752–14766, 2012. ista: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. 2012. Hippocampal place cells can encode multiple trial-dependent features through rate remapping. Journal of Neuroscience. 32(42), 14752–14766. mla: Allen, Kevin, et al. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through Rate Remapping.” Journal of Neuroscience, vol. 32, no. 42, Society for Neuroscience, 2012, pp. 14752–66, doi:10.1523/JNEUROSCI.6175-11.2012. short: K. Allen, J.N. Rawlins, D. Bannerman, J.L. Csicsvari, Journal of Neuroscience 32 (2012) 14752–14766. date_created: 2018-12-11T12:00:33Z date_published: 2012-10-17T00:00:00Z date_updated: 2021-01-12T07:40:03Z day: '17' department: - _id: JoCs doi: 10.1523/JNEUROSCI.6175-11.2012 ec_funded: 1 external_id: pmid: - '23077060' intvolume: ' 32' issue: '42' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531717/ month: '10' oa: 1 oa_version: Submitted Version page: 14752 - 14766 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '3768' quality_controlled: '1' scopus_import: 1 status: public title: Hippocampal place cells can encode multiple trial-dependent features through rate remapping type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 32 year: '2012' ... --- _id: '2959' abstract: - lang: eng text: We study maximum likelihood estimation in Gaussian graphical models from a geometric point of view. An algebraic elimination criterion allows us to find exact lower bounds on the number of observations needed to ensure that the maximum likelihood estimator (MLE) exists with probability one. This is applied to bipartite graphs, grids and colored graphs. We also study the ML degree, and we present the first instance of a graph for which the MLE exists with probability one, even when the number of observations equals the treewidth. acknowledgement: "I wish to thank Bernd Sturmfels for many helpful discus- sions and Steffen Lauritzen for introducing me to the problem of the existence of the MLE in Gaussian graphical models. I would also like to thank two referees who provided helpful comments on the original version of this paper.\r\n" author: - first_name: Caroline full_name: Uhler, Caroline id: 49ADD78E-F248-11E8-B48F-1D18A9856A87 last_name: Uhler orcid: 0000-0002-7008-0216 citation: ama: Uhler C. Geometry of maximum likelihood estimation in Gaussian graphical models. Annals of Statistics. 2012;40(1):238-261. doi:10.1214/11-AOS957 apa: Uhler, C. (2012). Geometry of maximum likelihood estimation in Gaussian graphical models. Annals of Statistics. Institute of Mathematical Statistics. https://doi.org/10.1214/11-AOS957 chicago: Uhler, Caroline. “Geometry of Maximum Likelihood Estimation in Gaussian Graphical Models.” Annals of Statistics. Institute of Mathematical Statistics, 2012. https://doi.org/10.1214/11-AOS957. ieee: C. Uhler, “Geometry of maximum likelihood estimation in Gaussian graphical models,” Annals of Statistics, vol. 40, no. 1. Institute of Mathematical Statistics, pp. 238–261, 2012. ista: Uhler C. 2012. Geometry of maximum likelihood estimation in Gaussian graphical models. Annals of Statistics. 40(1), 238–261. mla: Uhler, Caroline. “Geometry of Maximum Likelihood Estimation in Gaussian Graphical Models.” Annals of Statistics, vol. 40, no. 1, Institute of Mathematical Statistics, 2012, pp. 238–61, doi:10.1214/11-AOS957. short: C. Uhler, Annals of Statistics 40 (2012) 238–261. date_created: 2018-12-11T12:00:33Z date_published: 2012-02-01T00:00:00Z date_updated: 2021-01-12T07:40:04Z day: '01' department: - _id: CaUh doi: 10.1214/11-AOS957 intvolume: ' 40' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1012.2643 month: '02' oa: 1 oa_version: Preprint page: 238 - 261 publication: Annals of Statistics publication_status: published publisher: Institute of Mathematical Statistics publist_id: '3767' quality_controlled: '1' scopus_import: 1 status: public title: Geometry of maximum likelihood estimation in Gaussian graphical models type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 40 year: '2012' ... --- _id: '2966' abstract: - lang: eng text: 'Background: The outcome of male-male competition can be predicted from the relative fighting qualities of the opponents, which often depend on their age. In insects, freshly emerged and still sexually inactive males are morphologically indistinct from older, sexually active males. These young inactive males may thus be easy targets for older males if they cannot conceal themselves from their attacks. The ant Cardiocondyla obscurior is characterised by lethal fighting between wingless (" ergatoid" ) males. Here, we analyse for how long young males are defenceless after eclosion, and how early adult males can detect the presence of rival males.Results: We found that old ergatoid males consistently won fights against ergatoid males younger than two days. Old males did not differentiate between different types of unpigmented pupae several days before emergence, but had more frequent contact to ready-to-eclose pupae of female sexuals and winged males than of workers and ergatoid males. In rare cases, old ergatoid males displayed alleviated biting of pigmented ergatoid male pupae shortly before adult eclosion, as well as copulation attempts to dark pupae of female sexuals and winged males. Ergatoid male behaviour may be promoted by a closer similarity of the chemical profile of ready-to-eclose pupae to the profile of adults than that of young pupae several days prior to emergence.Conclusion: Young ergatoid males of C. obscurior would benefit greatly by hiding their identity from older, resident males, as they are highly vulnerable during the first two days of their adult lives. In contrast to the winged males of the same species, which are able to prevent ergatoid male attacks by chemical female mimicry, young ergatoids do not seem to be able to produce a protective chemical profile. Conflicts in male-male competition between ergatoid males of different age thus seem to be resolved in favour of the older males. This might represent selection at the colony level rather than the individual level. © 2012 Cremer et al.; licensee BioMed Central Ltd.' article_number: '7' author: - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Masaki full_name: Suefuji, Masaki last_name: Suefuji - first_name: Alexandra full_name: Schrempf, Alexandra last_name: Schrempf - first_name: Jürgen full_name: Heinze, Jürgen last_name: Heinze citation: ama: Cremer S, Suefuji M, Schrempf A, Heinze J. The dynamics of male-male competition in Cardiocondyla obscurior ants. BMC Ecology. 2012;12. doi:10.1186/1472-6785-12-7 apa: Cremer, S., Suefuji, M., Schrempf, A., & Heinze, J. (2012). The dynamics of male-male competition in Cardiocondyla obscurior ants. BMC Ecology. BioMed Central. https://doi.org/10.1186/1472-6785-12-7 chicago: Cremer, Sylvia, Masaki Suefuji, Alexandra Schrempf, and Jürgen Heinze. “The Dynamics of Male-Male Competition in Cardiocondyla Obscurior Ants.” BMC Ecology. BioMed Central, 2012. https://doi.org/10.1186/1472-6785-12-7. ieee: S. Cremer, M. Suefuji, A. Schrempf, and J. Heinze, “The dynamics of male-male competition in Cardiocondyla obscurior ants,” BMC Ecology, vol. 12. BioMed Central, 2012. ista: Cremer S, Suefuji M, Schrempf A, Heinze J. 2012. The dynamics of male-male competition in Cardiocondyla obscurior ants. BMC Ecology. 12, 7. mla: Cremer, Sylvia, et al. “The Dynamics of Male-Male Competition in Cardiocondyla Obscurior Ants.” BMC Ecology, vol. 12, 7, BioMed Central, 2012, doi:10.1186/1472-6785-12-7. short: S. Cremer, M. Suefuji, A. Schrempf, J. Heinze, BMC Ecology 12 (2012). date_created: 2018-12-11T12:00:35Z date_published: 2012-06-15T00:00:00Z date_updated: 2021-01-12T07:40:07Z day: '15' ddc: - '570' department: - _id: SyCr doi: 10.1186/1472-6785-12-7 file: - access_level: open_access checksum: 03d004bdff3724fb1627e3f5004bad80 content_type: application/pdf creator: system date_created: 2018-12-12T10:08:44Z date_updated: 2020-07-14T12:45:57Z file_id: '4706' file_name: IST-2012-94-v1+1_1472-6785-12-7.pdf file_size: 489994 relation: main_file file_date_updated: 2020-07-14T12:45:57Z has_accepted_license: '1' intvolume: ' 12' language: - iso: eng license: https://creativecommons.org/licenses/by/4.0/ month: '06' oa: 1 oa_version: Published Version publication: BMC Ecology publication_status: published publisher: BioMed Central publist_id: '3753' pubrep_id: '94' quality_controlled: '1' scopus_import: 1 status: public title: The dynamics of male-male competition in Cardiocondyla obscurior ants tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2012' ... --- _id: '2962' abstract: - lang: eng text: The choice of summary statistics is a crucial step in approximate Bayesian computation (ABC). Since statistics are often not sufficient, this choice involves a trade-off between loss of information and reduction of dimensionality. The latter may increase the efficiency of ABC. Here, we propose an approach for choosing summary statistics based on boosting, a technique from the machine learning literature. We consider different types of boosting and compare them to partial least squares regression as an alternative. To mitigate the lack of sufficiency, we also propose an approach for choosing summary statistics locally, in the putative neighborhood of the true parameter value. We study a demographic model motivated by the re-introduction of Alpine ibex (Capra ibex) into the Swiss Alps. The parameters of interest are the mean and standard deviation across microsatellites of the scaled ancestral mutation rate (θanc = 4 Ne u), and the proportion of males obtaining access to matings per breeding season (ω). By simulation, we assess the properties of the posterior distribution obtained with the various methods. According to our criteria, ABC with summary statistics chosen locally via boosting with the L2-loss performs best. Applying that method to the ibex data, we estimate θanc ≈ 1.288, and find that most of the variation across loci of the ancestral mutation rate u is between 7.7×10−4 and 3.5×10−3 per locus per generation. The proportion of males with access to matings is estimated to ω ≈ 0.21, which is in good agreement with recent independent estimates. acknowledged_ssus: - _id: ScienComp author: - first_name: Simon full_name: Aeschbacher, Simon id: 2D35326E-F248-11E8-B48F-1D18A9856A87 last_name: Aeschbacher - first_name: Mark full_name: Beaumont, Mark last_name: Beaumont - first_name: Andreas full_name: Futschik, Andreas last_name: Futschik citation: ama: Aeschbacher S, Beaumont M, Futschik A. A novel approach for choosing summary statistics in approximate Bayesian computation. Genetics. 2012;192(3):1027-1047. doi:10.1534/genetics.112.143164 apa: Aeschbacher, S., Beaumont, M., & Futschik, A. (2012). A novel approach for choosing summary statistics in approximate Bayesian computation. Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.112.143164 chicago: Aeschbacher, Simon, Mark Beaumont, and Andreas Futschik. “A Novel Approach for Choosing Summary Statistics in Approximate Bayesian Computation.” Genetics. Genetics Society of America, 2012. https://doi.org/10.1534/genetics.112.143164. ieee: S. Aeschbacher, M. Beaumont, and A. Futschik, “A novel approach for choosing summary statistics in approximate Bayesian computation,” Genetics, vol. 192, no. 3. Genetics Society of America, pp. 1027–1047, 2012. ista: Aeschbacher S, Beaumont M, Futschik A. 2012. A novel approach for choosing summary statistics in approximate Bayesian computation. Genetics. 192(3), 1027–1047. mla: Aeschbacher, Simon, et al. “A Novel Approach for Choosing Summary Statistics in Approximate Bayesian Computation.” Genetics, vol. 192, no. 3, Genetics Society of America, 2012, pp. 1027–47, doi:10.1534/genetics.112.143164. short: S. Aeschbacher, M. Beaumont, A. Futschik, Genetics 192 (2012) 1027–1047. date_created: 2018-12-11T12:00:34Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:40:05Z day: '01' department: - _id: NiBa doi: 10.1534/genetics.112.143164 external_id: pmid: - '22960215' intvolume: ' 192' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522150/ month: '11' oa: 1 oa_version: Submitted Version page: 1027 - 1047 pmid: 1 publication: Genetics publication_status: published publisher: Genetics Society of America publist_id: '3763' quality_controlled: '1' scopus_import: 1 status: public title: A novel approach for choosing summary statistics in approximate Bayesian computation type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 192 year: '2012' ... --- _id: '2965' abstract: - lang: eng text: Dieser Artikel soll die sechs verschiedenen Creative Commons Lizenzen erläutern und ihre Bedeutung im Rahmen des wissenschaftlichen Publizierens und des Open Access erklären (CC-BY, CC-BY-SA, CC-BY-NC, CC-BY-ND, CC-BYNC-SA, CC-BY-NC-ND). author: - first_name: Patrick full_name: Danowski, Patrick id: 2EBD1598-F248-11E8-B48F-1D18A9856A87 last_name: Danowski orcid: 0000-0002-6026-4409 citation: ama: 'Danowski P. Kontext Open Access: Creative Commons. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare. 2012;65(2):200-212.' apa: 'Danowski, P. (2012). Kontext Open Access: Creative Commons. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare. VÖB.' chicago: 'Danowski, Patrick. “Kontext Open Access: Creative Commons.” Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare. VÖB, 2012.' ieee: 'P. Danowski, “Kontext Open Access: Creative Commons,” Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare, vol. 65, no. 2. VÖB, pp. 200–212, 2012.' ista: 'Danowski P. 2012. Kontext Open Access: Creative Commons. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare. 65(2), 200–212.' mla: 'Danowski, Patrick. “Kontext Open Access: Creative Commons.” Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare, vol. 65, no. 2, VÖB, 2012, pp. 200–12.' short: P. Danowski, Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare 65 (2012) 200–212. date_created: 2018-12-11T12:00:35Z date_published: 2012-09-01T00:00:00Z date_updated: 2021-01-12T07:40:07Z day: '01' ddc: - '020' department: - _id: E-Lib file: - access_level: open_access checksum: 162eea47d9d840c26b496ba6ae4d1c09 content_type: application/pdf creator: system date_created: 2018-12-12T10:08:42Z date_updated: 2020-07-14T12:45:57Z file_id: '4703' file_name: IST-2012-95-v1+1_sp-beitrag_danowski_kontext_open_access_creative_commons.pdf file_size: 503345 relation: main_file file_date_updated: 2020-07-14T12:45:57Z has_accepted_license: '1' intvolume: ' 65' issue: '2' language: - iso: ger main_file_link: - open_access: '1' url: ' http://hdl.handle.net/10760/17625' month: '09' oa: 1 oa_version: Published Version page: 200 - 212 popular_science: '1' publication: Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare publication_status: published publisher: VÖB publist_id: '3754' pubrep_id: '95' scopus_import: 1 status: public title: 'Kontext Open Access: Creative Commons' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 65 year: '2012' ... --- _id: '2963' abstract: - lang: eng text: 'Zebra finches are an ubiquitous model system for the study of vocal learning in animal communication. Their song has been well described, but its possible function(s) in social communication are only partly understood. The so-called ‘directed song’ is a high-intensity, high-performance song given during courtship in close proximity to the female, which is known to mediate mate choice and mating. However, this singing mode constitutes only a fraction of zebra finch males’ prolific song output. Potential communicative functions of their second, ‘undirected’ singing mode remain unresolved in the face of contradicting reports of both facilitating and inhibiting effects of social company on singing. We addressed this issue by experimentally manipulating social contexts in a within-subject design, comparing a solo versus male or female only company condition, each lasting for 24 hours. Males’ total song output was significantly higher when a conspecific was in audible and visible distance than when they were alone. Male and female company had an equally facilitating effect on song output. Our findings thus indicate that singing motivation is facilitated rather than inhibited by social company, suggesting that singing in zebra finches might function both in inter- and intrasexual communication. ' author: - first_name: Fabienne full_name: Jesse, Fabienne id: 4C8C26A4-F248-11E8-B48F-1D18A9856A87 last_name: Jesse - first_name: Katharina full_name: Riebel, Katharina last_name: Riebel citation: ama: Jesse F, Riebel K. Social facilitation of male song by male and female conspecifics in the zebra finch, Taeniopygia guttata. Behavioural Processes. 2012;91(3):262-266. doi:10.1016/j.beproc.2012.09.006 apa: Jesse, F., & Riebel, K. (2012). Social facilitation of male song by male and female conspecifics in the zebra finch, Taeniopygia guttata. Behavioural Processes. Elsevier. https://doi.org/10.1016/j.beproc.2012.09.006 chicago: Jesse, Fabienne, and Katharina Riebel. “Social Facilitation of Male Song by Male and Female Conspecifics in the Zebra Finch, Taeniopygia Guttata.” Behavioural Processes. Elsevier, 2012. https://doi.org/10.1016/j.beproc.2012.09.006. ieee: F. Jesse and K. Riebel, “Social facilitation of male song by male and female conspecifics in the zebra finch, Taeniopygia guttata,” Behavioural Processes, vol. 91, no. 3. Elsevier, pp. 262–266, 2012. ista: Jesse F, Riebel K. 2012. Social facilitation of male song by male and female conspecifics in the zebra finch, Taeniopygia guttata. Behavioural Processes. 91(3), 262–266. mla: Jesse, Fabienne, and Katharina Riebel. “Social Facilitation of Male Song by Male and Female Conspecifics in the Zebra Finch, Taeniopygia Guttata.” Behavioural Processes, vol. 91, no. 3, Elsevier, 2012, pp. 262–66, doi:10.1016/j.beproc.2012.09.006. short: F. Jesse, K. Riebel, Behavioural Processes 91 (2012) 262–266. date_created: 2018-12-11T12:00:35Z date_published: 2012-11-01T00:00:00Z date_updated: 2021-01-12T07:40:06Z day: '01' department: - _id: JoBo doi: 10.1016/j.beproc.2012.09.006 intvolume: ' 91' issue: '3' language: - iso: eng month: '11' oa_version: None page: 262 - 266 publication: Behavioural Processes publication_status: published publisher: Elsevier publist_id: '3756' quality_controlled: '1' status: public title: Social facilitation of male song by male and female conspecifics in the zebra finch, Taeniopygia guttata type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 91 year: '2012' ... --- _id: '2974' abstract: - lang: eng text: "We construct a perfectly binding string commitment scheme whose security is based on the learning parity with noise (LPN) assumption, or equivalently, the hardness of decoding random linear codes. Our scheme not only allows for a simple and efficient zero-knowledge proof of knowledge for committed values (essentially a Σ-protocol), but also for such proofs showing any kind of relation amongst committed values, i.e. proving that messages m_0,...,m_u, are such that m_0=C(m_1,...,m_u) for any circuit C.\r\n\r\nTo get soundness which is exponentially small in a security parameter t, and when the zero-knowledge property relies on the LPN problem with secrets of length l, our 3 round protocol has communication complexity O(t|C|l log(l)) and computational complexity of O(t|C|l) bit operations. The hidden constants are small, and the computation consists mostly of computing inner products of bit-vectors." acknowledgement: "We are grateful to Petros Mol for helpful discussions on the reduction for the hardness of the xLPN problem.\r\n" alternative_title: - LNCS author: - first_name: Abhishek full_name: Jain, Abhishek last_name: Jain - first_name: Stephan full_name: Krenn, Stephan id: 329FCCF0-F248-11E8-B48F-1D18A9856A87 last_name: Krenn orcid: 0000-0003-2835-9093 - first_name: Krzysztof Z full_name: Pietrzak, Krzysztof Z id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 - first_name: Aris full_name: Tentes, Aris last_name: Tentes citation: ama: 'Jain A, Krenn S, Pietrzak KZ, Tentes A. Commitments and efficient zero knowledge proofs from learning parity with noise. In: Wang X, Sako K, eds. Vol 7658. Springer; 2012:663-680. doi:10.1007/978-3-642-34961-4_40' apa: 'Jain, A., Krenn, S., Pietrzak, K. Z., & Tentes, A. (2012). Commitments and efficient zero knowledge proofs from learning parity with noise. In X. Wang & K. Sako (Eds.) (Vol. 7658, pp. 663–680). Presented at the ASIACRYPT: Theory and Application of Cryptology and Information Security, Beijing, China: Springer. https://doi.org/10.1007/978-3-642-34961-4_40' chicago: Jain, Abhishek, Stephan Krenn, Krzysztof Z Pietrzak, and Aris Tentes. “Commitments and Efficient Zero Knowledge Proofs from Learning Parity with Noise.” edited by Xiaoyun Wang and Kazue Sako, 7658:663–80. Springer, 2012. https://doi.org/10.1007/978-3-642-34961-4_40. ieee: 'A. Jain, S. Krenn, K. Z. Pietrzak, and A. Tentes, “Commitments and efficient zero knowledge proofs from learning parity with noise,” presented at the ASIACRYPT: Theory and Application of Cryptology and Information Security, Beijing, China, 2012, vol. 7658, pp. 663–680.' ista: 'Jain A, Krenn S, Pietrzak KZ, Tentes A. 2012. Commitments and efficient zero knowledge proofs from learning parity with noise. ASIACRYPT: Theory and Application of Cryptology and Information Security, LNCS, vol. 7658, 663–680.' mla: Jain, Abhishek, et al. Commitments and Efficient Zero Knowledge Proofs from Learning Parity with Noise. Edited by Xiaoyun Wang and Kazue Sako, vol. 7658, Springer, 2012, pp. 663–80, doi:10.1007/978-3-642-34961-4_40. short: A. Jain, S. Krenn, K.Z. Pietrzak, A. Tentes, in:, X. Wang, K. Sako (Eds.), Springer, 2012, pp. 663–680. conference: end_date: 2012-12-06 location: Beijing, China name: 'ASIACRYPT: Theory and Application of Cryptology and Information Security' start_date: 2012-12-02 date_created: 2018-12-11T12:00:38Z date_published: 2012-12-01T00:00:00Z date_updated: 2021-01-12T07:40:11Z day: '01' ddc: - '004' - '005' department: - _id: KrPi doi: 10.1007/978-3-642-34961-4_40 ec_funded: 1 editor: - first_name: Xiaoyun full_name: Wang, Xiaoyun last_name: Wang - first_name: Kazue full_name: Sako, Kazue last_name: Sako file: - access_level: open_access checksum: ab879537385efc4cb4203e7ef0fea17b content_type: application/pdf creator: system date_created: 2018-12-12T10:14:00Z date_updated: 2020-07-14T12:45:58Z file_id: '5048' file_name: IST-2016-721-v1+1_513.pdf file_size: 482570 relation: main_file file_date_updated: 2020-07-14T12:45:58Z has_accepted_license: '1' intvolume: ' 7658' language: - iso: eng month: '12' oa: 1 oa_version: Submitted Version page: 663 - 680 project: - _id: 258C570E-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '259668' name: Provable Security for Physical Cryptography publication_status: published publisher: Springer publist_id: '3730' pubrep_id: '721' scopus_import: 1 status: public title: Commitments and efficient zero knowledge proofs from learning parity with noise tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 7658 year: '2012' ... --- _id: '2969' abstract: - lang: eng text: "The coupling between presynaptic Ca^(2+) channels and Ca^(2+) sensors of exocytosis is a key determinant of synaptic transmission. Evoked release from parvalbumin (PV)-expressing interneurons is triggered by nanodomain coupling of P/Q-type Ca^(2+) channels, whereas release from cholecystokinin (CCK)-containing interneurons is generated by microdomain coupling of N-type channels. Nanodomain coupling has several functional advantages, including speed and efficacy of transmission. One potential disadvantage is that stochastic\r\nopening of presynaptic Ca^(2+) channels may trigger spontaneous transmitter release. We addressed this possibility in rat hippocampal\r\ngranule cells, which receive converging inputs from different inhibitory sources. Both reduction of extracellular Ca^(2+) concentration and the unselective Ca^(2+) channel blocker Cd^(2+) reduced the frequency of miniature IPSCs (mIPSCs) in granule cells by ~50%, suggesting that the opening of presynaptic Ca^(2+) channels contributes to spontaneous release. Application of the selective P/Q-type Ca^(2+) channel blocker\r\nω-agatoxin IVa had no detectable effects, whereas both the N-type blocker ω-conotoxin GVIa and the L-type blocker nimodipine reduced\r\nmIPSC frequency. Furthermore, both the fast Ca^(2+) chelator BAPTA-AM and the slow chelator EGTA-AM reduced the mIPSC frequency,\r\nsuggesting that Ca^(2+)-dependent spontaneous release is triggered by microdomain rather than nanodomain coupling. The CB_(1) receptor\r\nagonist WIN 55212-2 also decreased spontaneous release; this effect was occluded by prior application of ω-conotoxin GVIa, suggesting that a major fraction of Ca^(2+)-dependent spontaneous release was generated at the terminals of CCK-expressing interneurons. Tonic inhibition generated by spontaneous opening of presynaptic N- and L-type Ca^(2+) channels may be important for hippocampal information processing.\r\n" acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR 3/B10, Leibniz program, GSC-4 Spemann Graduate School) and the European Union (European Research Council Advanced Grant). author: - first_name: Sarit full_name: Goswami, Sarit id: 3A578F32-F248-11E8-B48F-1D18A9856A87 last_name: Goswami - first_name: Iancu full_name: Bucurenciu, Iancu last_name: Bucurenciu - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Goswami S, Bucurenciu I, Jonas PM. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. Journal of Neuroscience. 2012;32(41):14294-14304. doi:10.1523/JNEUROSCI.6104-11.2012 apa: Goswami, S., Bucurenciu, I., & Jonas, P. M. (2012). Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6104-11.2012 chicago: Goswami, Sarit, Iancu Bucurenciu, and Peter M Jonas. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.6104-11.2012. ieee: S. Goswami, I. Bucurenciu, and P. M. Jonas, “Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling,” Journal of Neuroscience, vol. 32, no. 41. Society for Neuroscience, pp. 14294–14304, 2012. ista: Goswami S, Bucurenciu I, Jonas PM. 2012. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. Journal of Neuroscience. 32(41), 14294–14304. mla: Goswami, Sarit, et al. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” Journal of Neuroscience, vol. 32, no. 41, Society for Neuroscience, 2012, pp. 14294–304, doi:10.1523/JNEUROSCI.6104-11.2012. short: S. Goswami, I. Bucurenciu, P.M. Jonas, Journal of Neuroscience 32 (2012) 14294–14304. date_created: 2018-12-11T12:00:36Z date_published: 2012-10-10T00:00:00Z date_updated: 2021-01-12T07:40:08Z day: '10' department: - _id: PeJo doi: 10.1523/JNEUROSCI.6104-11.2012 external_id: pmid: - '23055500' intvolume: ' 32' issue: '41' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632771/ month: '10' oa: 1 oa_version: Submitted Version page: 14294 - 14304 pmid: 1 project: - _id: 25BDE9A4-B435-11E9-9278-68D0E5697425 grant_number: SFB-TR3-TP10B name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '3744' quality_controlled: '1' scopus_import: 1 status: public title: Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 32 year: '2012' ...