---
_id: '1898'
abstract:
- lang: eng
text: Fast synaptic transmission is important for rapid information processing.
To explore the maximal rate of neuronal signaling and to analyze the presynaptic
mechanisms, we focused on the input layer of the cerebellar cortex, where exceptionally
high action potential (AP) frequencies have been reported invivo. With paired
recordings between presynaptic cerebellar mossy fiber boutons and postsynaptic
granule cells, we demonstrate reliable neurotransmission upto ~1 kHz. Presynaptic
APs are ultrafast, with ~100μs half-duration. Both Kv1 and Kv3 potassium channels
mediate the fast repolarization, rapidly inactivating sodium channels ensure metabolic
efficiency, and little AP broadening occurs during bursts of up to 1.5 kHz. Presynaptic
Cav2.1 (P/Q-type) calcium channels open efficiently during ultrafast APs. Furthermore,
a subset of synaptic vesicles is tightly coupled to Ca2+ channels, and vesicles
are rapidly recruited to the release site. These data reveal mechanisms of presynaptic
AP generation and transmitter release underlying neuronal kHz signaling.
author:
- first_name: Andreas
full_name: Ritzau Jost, Andreas
last_name: Ritzau Jost
- first_name: Igor
full_name: Delvendahl, Igor
last_name: Delvendahl
- first_name: Annika
full_name: Rings, Annika
last_name: Rings
- first_name: Niklas
full_name: Byczkowicz, Niklas
last_name: Byczkowicz
- first_name: Harumi
full_name: Harada, Harumi
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Johannes
full_name: Hirrlinger, Johannes
last_name: Hirrlinger
- first_name: Jens
full_name: Eilers, Jens
last_name: Eilers
- first_name: Stefan
full_name: Hallermann, Stefan
last_name: Hallermann
citation:
ama: Ritzau Jost A, Delvendahl I, Rings A, et al. Ultrafast action potentials mediate
kilohertz signaling at a central synapse. Neuron. 2014;84(1):152-163. doi:10.1016/j.neuron.2014.08.036
apa: Ritzau Jost, A., Delvendahl, I., Rings, A., Byczkowicz, N., Harada, H., Shigemoto,
R., … Hallermann, S. (2014). Ultrafast action potentials mediate kilohertz signaling
at a central synapse. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.08.036
chicago: Ritzau Jost, Andreas, Igor Delvendahl, Annika Rings, Niklas Byczkowicz,
Harumi Harada, Ryuichi Shigemoto, Johannes Hirrlinger, Jens Eilers, and Stefan
Hallermann. “Ultrafast Action Potentials Mediate Kilohertz Signaling at a Central
Synapse.” Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.08.036.
ieee: A. Ritzau Jost et al., “Ultrafast action potentials mediate kilohertz
signaling at a central synapse,” Neuron, vol. 84, no. 1. Elsevier, pp.
152–163, 2014.
ista: Ritzau Jost A, Delvendahl I, Rings A, Byczkowicz N, Harada H, Shigemoto R,
Hirrlinger J, Eilers J, Hallermann S. 2014. Ultrafast action potentials mediate
kilohertz signaling at a central synapse. Neuron. 84(1), 152–163.
mla: Ritzau Jost, Andreas, et al. “Ultrafast Action Potentials Mediate Kilohertz
Signaling at a Central Synapse.” Neuron, vol. 84, no. 1, Elsevier, 2014,
pp. 152–63, doi:10.1016/j.neuron.2014.08.036.
short: A. Ritzau Jost, I. Delvendahl, A. Rings, N. Byczkowicz, H. Harada, R. Shigemoto,
J. Hirrlinger, J. Eilers, S. Hallermann, Neuron 84 (2014) 152–163.
date_created: 2018-12-11T11:54:36Z
date_published: 2014-10-01T00:00:00Z
date_updated: 2021-01-12T06:53:55Z
day: '01'
department:
- _id: RySh
doi: 10.1016/j.neuron.2014.08.036
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '10'
oa_version: None
page: 152 - 163
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5197'
quality_controlled: '1'
scopus_import: 1
status: public
title: Ultrafast action potentials mediate kilohertz signaling at a central synapse
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2014'
...
---
_id: '1906'
abstract:
- lang: eng
text: In this paper, we introduce a novel scene representation for the visualization
of large-scale point clouds accompanied by a set of high-resolution photographs.
Many real-world applications deal with very densely sampled point-cloud data,
which are augmented with photographs that often reveal lighting variations and
inaccuracies in registration. Consequently, the high-quality representation of
the captured data, i.e., both point clouds and photographs together, is a challenging
and time-consuming task. We propose a two-phase approach, in which the first (preprocessing)
phase generates multiple overlapping surface patches and handles the problem of
seamless texture generation locally for each patch. The second phase stitches
these patches at render-time to produce a high-quality visualization of the data.
As a result of the proposed localization of the global texturing problem, our
algorithm is more than an order of magnitude faster than equivalent mesh-based
texturing techniques. Furthermore, since our preprocessing phase requires only
a minor fraction of the whole data set at once, we provide maximum flexibility
when dealing with growing data sets.
acknowledgement: This research was supported by the Austrian Research Promotion Agency
(FFG) project REPLICATE (no. 835948), the EU FP7 project HARVEST4D (no. 323567).
author:
- first_name: Murat
full_name: Arikan, Murat
last_name: Arikan
- first_name: Reinhold
full_name: Preiner, Reinhold
last_name: Preiner
- first_name: Claus
full_name: Scheiblauer, Claus
last_name: Scheiblauer
- first_name: Stefan
full_name: Jeschke, Stefan
id: 44D6411A-F248-11E8-B48F-1D18A9856A87
last_name: Jeschke
- first_name: Michael
full_name: Wimmer, Michael
last_name: Wimmer
citation:
ama: Arikan M, Preiner R, Scheiblauer C, Jeschke S, Wimmer M. Large-scale point-cloud
visualization through localized textured surface reconstruction. IEEE Transactions
on Visualization and Computer Graphics. 2014;20(9):1280-1292. doi:10.1109/TVCG.2014.2312011
apa: Arikan, M., Preiner, R., Scheiblauer, C., Jeschke, S., & Wimmer, M. (2014).
Large-scale point-cloud visualization through localized textured surface reconstruction.
IEEE Transactions on Visualization and Computer Graphics. IEEE. https://doi.org/10.1109/TVCG.2014.2312011
chicago: Arikan, Murat, Reinhold Preiner, Claus Scheiblauer, Stefan Jeschke, and
Michael Wimmer. “Large-Scale Point-Cloud Visualization through Localized Textured
Surface Reconstruction.” IEEE Transactions on Visualization and Computer Graphics.
IEEE, 2014. https://doi.org/10.1109/TVCG.2014.2312011.
ieee: M. Arikan, R. Preiner, C. Scheiblauer, S. Jeschke, and M. Wimmer, “Large-scale
point-cloud visualization through localized textured surface reconstruction,”
IEEE Transactions on Visualization and Computer Graphics, vol. 20, no.
9. IEEE, pp. 1280–1292, 2014.
ista: Arikan M, Preiner R, Scheiblauer C, Jeschke S, Wimmer M. 2014. Large-scale
point-cloud visualization through localized textured surface reconstruction. IEEE
Transactions on Visualization and Computer Graphics. 20(9), 1280–1292.
mla: Arikan, Murat, et al. “Large-Scale Point-Cloud Visualization through Localized
Textured Surface Reconstruction.” IEEE Transactions on Visualization and Computer
Graphics, vol. 20, no. 9, IEEE, 2014, pp. 1280–92, doi:10.1109/TVCG.2014.2312011.
short: M. Arikan, R. Preiner, C. Scheiblauer, S. Jeschke, M. Wimmer, IEEE Transactions
on Visualization and Computer Graphics 20 (2014) 1280–1292.
date_created: 2018-12-11T11:54:39Z
date_published: 2014-09-09T00:00:00Z
date_updated: 2021-01-12T06:53:59Z
day: '09'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1109/TVCG.2014.2312011
file:
- access_level: open_access
checksum: 5bf58942d2eb20adf03c7f9ea2e68124
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:41Z
date_updated: 2020-07-14T12:45:20Z
file_id: '5297'
file_name: IST-2016-573-v1+1_arikan-2014-pcvis-draft.pdf
file_size: 13594598
relation: main_file
file_date_updated: 2020-07-14T12:45:20Z
has_accepted_license: '1'
intvolume: ' 20'
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 1280 - 1292
project:
- _id: 25357BD2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 24352-N23
name: 'Deep Pictures: Creating Visual and Haptic Vector Images'
publication: IEEE Transactions on Visualization and Computer Graphics
publication_status: published
publisher: IEEE
publist_id: '5189'
pubrep_id: '573'
scopus_import: 1
status: public
title: Large-scale point-cloud visualization through localized textured surface reconstruction
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2014'
...
---
_id: '1905'
abstract:
- lang: eng
text: The unprecedented polymorphism in the major histocompatibility complex (MHC)
genes is thought to be maintained by balancing selection from parasites. However,
do parasites also drive divergence at MHC loci between host populations, or do
the effects of balancing selection maintain similarities among populations? We
examined MHC variation in populations of the livebearing fish Poecilia mexicana
and characterized their parasite communities. Poecilia mexicana populations in
the Cueva del Azufre system are locally adapted to darkness and the presence of
toxic hydrogen sulphide, representing highly divergent ecotypes or incipient species.
Parasite communities differed significantly across populations, and populations
with higher parasite loads had higher levels of diversity at class II MHC genes.
However, despite different parasite communities, marked divergence in adaptive
traits and in neutral genetic markers, we found MHC alleles to be remarkably similar
among host populations. Our findings indicate that balancing selection from parasites
maintains immunogenetic diversity of hosts, but this process does not promote
MHC divergence in this system. On the contrary, we suggest that balancing selection
on immunogenetic loci may outweigh divergent selection causing divergence, thereby
hindering host divergence and speciation. Our findings support the hypothesis
that balancing selection maintains MHC similarities among lineages during and
after speciation (trans-species evolution).
acknowledgement: This study was funded by grants from the National Science Foundation
(NSF) to MT (IOS-1121832) and IS (DEB-0743406) and from the German Science Foundation
(DFG; PL 470/1-2) and ‘LOEWE − Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer
Exzellenz’ of Hesse's Ministry of Higher Education, Research, and the Arts, to MP.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Tobler, Michael
last_name: Tobler
- first_name: Martin
full_name: Plath, Martin
last_name: Plath
- first_name: Rüdiger
full_name: Riesch, Rüdiger
last_name: Riesch
- first_name: Ingo
full_name: Schlupp, Ingo
last_name: Schlupp
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Gopi
full_name: Munimanda, Gopi
last_name: Munimanda
- first_name: C
full_name: Setzer, C
last_name: Setzer
- first_name: Dustin
full_name: Penn, Dustin
last_name: Penn
- first_name: Yoshan
full_name: Moodley, Yoshan
last_name: Moodley
citation:
ama: Tobler M, Plath M, Riesch R, et al. Selection from parasites favours immunogenetic
diversity but not divergence among locally adapted host populations. Journal
of Evolutionary Biology. 2014;27(5):960-974. doi:10.1111/jeb.12370
apa: Tobler, M., Plath, M., Riesch, R., Schlupp, I., Grasse, A. V., Munimanda, G.,
… Moodley, Y. (2014). Selection from parasites favours immunogenetic diversity
but not divergence among locally adapted host populations. Journal of Evolutionary
Biology. Wiley. https://doi.org/10.1111/jeb.12370
chicago: Tobler, Michael, Martin Plath, Rüdiger Riesch, Ingo Schlupp, Anna V Grasse,
Gopi Munimanda, C Setzer, Dustin Penn, and Yoshan Moodley. “Selection from Parasites
Favours Immunogenetic Diversity but Not Divergence among Locally Adapted Host
Populations.” Journal of Evolutionary Biology. Wiley, 2014. https://doi.org/10.1111/jeb.12370.
ieee: M. Tobler et al., “Selection from parasites favours immunogenetic diversity
but not divergence among locally adapted host populations,” Journal of Evolutionary
Biology, vol. 27, no. 5. Wiley, pp. 960–974, 2014.
ista: Tobler M, Plath M, Riesch R, Schlupp I, Grasse AV, Munimanda G, Setzer C,
Penn D, Moodley Y. 2014. Selection from parasites favours immunogenetic diversity
but not divergence among locally adapted host populations. Journal of Evolutionary
Biology. 27(5), 960–974.
mla: Tobler, Michael, et al. “Selection from Parasites Favours Immunogenetic Diversity
but Not Divergence among Locally Adapted Host Populations.” Journal of Evolutionary
Biology, vol. 27, no. 5, Wiley, 2014, pp. 960–74, doi:10.1111/jeb.12370.
short: M. Tobler, M. Plath, R. Riesch, I. Schlupp, A.V. Grasse, G. Munimanda, C.
Setzer, D. Penn, Y. Moodley, Journal of Evolutionary Biology 27 (2014) 960–974.
date_created: 2018-12-11T11:54:38Z
date_published: 2014-04-12T00:00:00Z
date_updated: 2022-06-07T09:22:20Z
day: '12'
department:
- _id: SyCr
doi: 10.1111/jeb.12370
external_id:
pmid:
- '24725091'
intvolume: ' 27'
issue: '5'
language:
- iso: eng
month: '04'
oa_version: None
page: 960 - 974
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
publist_id: '5190'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selection from parasites favours immunogenetic diversity but not divergence
among locally adapted host populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2014'
...
---
_id: '1902'
abstract:
- lang: eng
text: In the 1960s-1980s, determination of bacterial growth rates was an important
tool in microbial genetics, biochemistry, molecular biology, and microbial physiology.
The exciting technical developments of the 1990s and the 2000s eclipsed that tool;
as a result, many investigators today lack experience with growth rate measurements.
Recently, investigators in a number of areas have started to use measurements
of bacterial growth rates for a variety of purposes. Those measurements have been
greatly facilitated by the availability of microwell plate readers that permit
the simultaneous measurements on up to 384 different cultures. Only the exponential
(logarithmic) portions of the resulting growth curves are useful for determining
growth rates, and manual determination of that portion and calculation of growth
rates can be tedious for high-throughput purposes. Here, we introduce the program
GrowthRates that uses plate reader output files to automatically determine the
exponential portion of the curve and to automatically calculate the growth rate,
the maximum culture density, and the duration of the growth lag phase. GrowthRates
is freely available for Macintosh, Windows, and Linux.We discuss the effects of
culture volume, the classical bacterial growth curve, and the differences between
determinations in rich media and minimal (mineral salts) media. This protocol
covers calibration of the plate reader, growth of culture inocula for both rich
and minimal media, and experimental setup. As a guide to reliability, we report
typical day-to-day variation in growth rates and variation within experiments
with respect to position of wells within the plates.
article_processing_charge: No
article_type: original
author:
- first_name: Barry
full_name: Hall, Barry
last_name: Hall
- first_name: Hande
full_name: Acar, Hande
id: 2DDF136A-F248-11E8-B48F-1D18A9856A87
last_name: Acar
orcid: 0000-0003-1986-9753
- first_name: Anna
full_name: Nandipati, Anna
last_name: Nandipati
- first_name: Miriam
full_name: Barlow, Miriam
last_name: Barlow
citation:
ama: Hall B, Acar H, Nandipati A, Barlow M. Growth rates made easy. Molecular
Biology and Evolution. 2014;31(1):232-238. doi:10.1093/molbev/mst187
apa: Hall, B., Acar, H., Nandipati, A., & Barlow, M. (2014). Growth rates made
easy. Molecular Biology and Evolution. Oxford University Press. https://doi.org/10.1093/molbev/mst187
chicago: Hall, Barry, Hande Acar, Anna Nandipati, and Miriam Barlow. “Growth Rates
Made Easy.” Molecular Biology and Evolution. Oxford University Press, 2014.
https://doi.org/10.1093/molbev/mst187.
ieee: B. Hall, H. Acar, A. Nandipati, and M. Barlow, “Growth rates made easy,” Molecular
Biology and Evolution, vol. 31, no. 1. Oxford University Press, pp. 232–238,
2014.
ista: Hall B, Acar H, Nandipati A, Barlow M. 2014. Growth rates made easy. Molecular
Biology and Evolution. 31(1), 232–238.
mla: Hall, Barry, et al. “Growth Rates Made Easy.” Molecular Biology and Evolution,
vol. 31, no. 1, Oxford University Press, 2014, pp. 232–38, doi:10.1093/molbev/mst187.
short: B. Hall, H. Acar, A. Nandipati, M. Barlow, Molecular Biology and Evolution
31 (2014) 232–238.
date_created: 2018-12-11T11:54:37Z
date_published: 2014-01-01T00:00:00Z
date_updated: 2022-06-07T11:08:13Z
day: '01'
department:
- _id: JoBo
doi: 10.1093/molbev/mst187
external_id:
pmid:
- '24170494'
intvolume: ' 31'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 232 - 238
pmid: 1
publication: Molecular Biology and Evolution
publication_identifier:
eissn:
- 1537-1719
issn:
- 0737-4038
publication_status: published
publisher: Oxford University Press
publist_id: '5193'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Growth rates made easy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2014'
...
---
_id: '1901'
abstract:
- lang: eng
text: In plants, the patterning of stem cell-enriched meristems requires a graded
auxin response maximum that emerges from the concerted action of polar auxin transport,
auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However,
mechanisms underlying this auxin response maximum-mediated root stem cell maintenance
are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED
HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic
genes in the quiescent center (QC) of the root and thus provides a robust mechanism
for the maintenance of auxin response maximum in the root tip. This WOX5 action
is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response
repressor. Our combined genetic, cell biology, and computational modeling studies
revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin
production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback
circuit further assures the maintenance of auxin response maximum in the root
tip and thereby contributes to the maintenance of distal stem cell (DSC) populations.
Our experimental studies and in silico computer simulations both demonstrate that
the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient
in the root tip and the auxin-mediated root DSC differentiation.
acknowledgement: "This work was supported by funding from the projects CZ.1.07/2.3.00/20.0043
and CZ.1.05/1.1.00/02.0068 (to CEITEC, Central European Institute of Technology)
and the Odysseus program of the Research Foundation-Flanders to J.F\r\n"
author:
- first_name: Huiyu
full_name: Tian, Huiyu
last_name: Tian
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
last_name: Wabnik
- first_name: Tiantian
full_name: Niu, Tiantian
last_name: Niu
- first_name: Hongjiang
full_name: Li, Hongjiang
last_name: Li
- first_name: Qianqian
full_name: Yu, Qianqian
last_name: Yu
- first_name: Stephan
full_name: Pollmann, Stephan
last_name: Pollmann
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Willy
full_name: Govaerts, Willy
last_name: Govaerts
- first_name: Jakub
full_name: Rolčík, Jakub
last_name: Rolčík
- first_name: Markus
full_name: Geisler, Markus
last_name: Geisler
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Zhaojun
full_name: Ding, Zhaojun
last_name: Ding
citation:
ama: Tian H, Wabnik KT, Niu T, et al. WOX5-IAA17 feedback circuit-mediated cellular
auxin response is crucial for the patterning of root stem cell niches in arabidopsis.
Molecular Plant. 2014;7(2):277-289. doi:10.1093/mp/sst118
apa: Tian, H., Wabnik, K. T., Niu, T., Li, H., Yu, Q., Pollmann, S., … Ding, Z.
(2014). WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial
for the patterning of root stem cell niches in arabidopsis. Molecular Plant.
Oxford University Press. https://doi.org/10.1093/mp/sst118
chicago: Tian, Huiyu, Krzysztof T Wabnik, Tiantian Niu, Hongjiang Li, Qianqian Yu,
Stephan Pollmann, Steffen Vanneste, et al. “WOX5-IAA17 Feedback Circuit-Mediated
Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches
in Arabidopsis.” Molecular Plant. Oxford University Press, 2014. https://doi.org/10.1093/mp/sst118.
ieee: H. Tian et al., “WOX5-IAA17 feedback circuit-mediated cellular auxin
response is crucial for the patterning of root stem cell niches in arabidopsis,”
Molecular Plant, vol. 7, no. 2. Oxford University Press, pp. 277–289, 2014.
ista: Tian H, Wabnik KT, Niu T, Li H, Yu Q, Pollmann S, Vanneste S, Govaerts W,
Rolčík J, Geisler M, Friml J, Ding Z. 2014. WOX5-IAA17 feedback circuit-mediated
cellular auxin response is crucial for the patterning of root stem cell niches
in arabidopsis. Molecular Plant. 7(2), 277–289.
mla: Tian, Huiyu, et al. “WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response
Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis.” Molecular
Plant, vol. 7, no. 2, Oxford University Press, 2014, pp. 277–89, doi:10.1093/mp/sst118.
short: H. Tian, K.T. Wabnik, T. Niu, H. Li, Q. Yu, S. Pollmann, S. Vanneste, W.
Govaerts, J. Rolčík, M. Geisler, J. Friml, Z. Ding, Molecular Plant 7 (2014) 277–289.
date_created: 2018-12-11T11:54:37Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2021-01-12T06:53:57Z
day: '01'
department:
- _id: JiFr
doi: 10.1093/mp/sst118
intvolume: ' 7'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 277 - 289
publication: Molecular Plant
publication_status: published
publisher: Oxford University Press
publist_id: '5194'
scopus_import: 1
status: public
title: WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for
the patterning of root stem cell niches in arabidopsis
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2014'
...
---
_id: '1904'
abstract:
- lang: eng
text: We prove a Strichartz inequality for a system of orthonormal functions, with
an optimal behavior of the constant in the limit of a large number of functions.
The estimate generalizes the usual Strichartz inequality, in the same fashion
as the Lieb-Thirring inequality generalizes the Sobolev inequality. As an application,
we consider the Schrödinger equation with a time-dependent potential and we show
the existence of the wave operator in Schatten spaces.
author:
- first_name: Rupert
full_name: Frank, Rupert
last_name: Frank
- first_name: Mathieu
full_name: Lewin, Mathieu
last_name: Lewin
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Frank R, Lewin M, Lieb É, Seiringer R. Strichartz inequality for orthonormal
functions. Journal of the European Mathematical Society. 2014;16(7):1507-1526.
doi:10.4171/JEMS/467
apa: Frank, R., Lewin, M., Lieb, É., & Seiringer, R. (2014). Strichartz inequality
for orthonormal functions. Journal of the European Mathematical Society.
European Mathematical Society. https://doi.org/10.4171/JEMS/467
chicago: Frank, Rupert, Mathieu Lewin, Élliott Lieb, and Robert Seiringer. “Strichartz
Inequality for Orthonormal Functions.” Journal of the European Mathematical
Society. European Mathematical Society, 2014. https://doi.org/10.4171/JEMS/467.
ieee: R. Frank, M. Lewin, É. Lieb, and R. Seiringer, “Strichartz inequality for
orthonormal functions,” Journal of the European Mathematical Society, vol.
16, no. 7. European Mathematical Society, pp. 1507–1526, 2014.
ista: Frank R, Lewin M, Lieb É, Seiringer R. 2014. Strichartz inequality for orthonormal
functions. Journal of the European Mathematical Society. 16(7), 1507–1526.
mla: Frank, Rupert, et al. “Strichartz Inequality for Orthonormal Functions.” Journal
of the European Mathematical Society, vol. 16, no. 7, European Mathematical
Society, 2014, pp. 1507–26, doi:10.4171/JEMS/467.
short: R. Frank, M. Lewin, É. Lieb, R. Seiringer, Journal of the European Mathematical
Society 16 (2014) 1507–1526.
date_created: 2018-12-11T11:54:38Z
date_published: 2014-08-23T00:00:00Z
date_updated: 2021-01-12T06:53:58Z
day: '23'
department:
- _id: RoSe
doi: 10.4171/JEMS/467
intvolume: ' 16'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1306.1309
month: '08'
oa: 1
oa_version: Submitted Version
page: 1507 - 1526
project:
- _id: 26450934-B435-11E9-9278-68D0E5697425
name: NSERC Postdoctoral fellowship
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society
publist_id: '5191'
quality_controlled: '1'
scopus_import: 1
status: public
title: Strichartz inequality for orthonormal functions
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2014'
...
---
_id: '1900'
abstract:
- lang: eng
text: Epithelial cell layers need to be tightly regulated to maintain their integrity
and correct function. Cell integration into epithelial sheets is now shown to
depend on the N-WASP-regulated stabilization of cortical F-actin, which generates
distinct patterns of apical-lateral contractility at E-cadherin-based cell-cell
junctions.
author:
- first_name: Martin
full_name: Behrndt, Martin
id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
last_name: Behrndt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Behrndt M, Heisenberg C-PJ. Lateral junction dynamics lead the way out. Nature
Cell Biology. 2014;16(2):127-129. doi:10.1038/ncb2913
apa: Behrndt, M., & Heisenberg, C.-P. J. (2014). Lateral junction dynamics lead
the way out. Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/ncb2913
chicago: Behrndt, Martin, and Carl-Philipp J Heisenberg. “Lateral Junction Dynamics
Lead the Way Out.” Nature Cell Biology. Nature Publishing Group, 2014.
https://doi.org/10.1038/ncb2913.
ieee: M. Behrndt and C.-P. J. Heisenberg, “Lateral junction dynamics lead the way
out,” Nature Cell Biology, vol. 16, no. 2. Nature Publishing Group, pp.
127–129, 2014.
ista: Behrndt M, Heisenberg C-PJ. 2014. Lateral junction dynamics lead the way out.
Nature Cell Biology. 16(2), 127–129.
mla: Behrndt, Martin, and Carl-Philipp J. Heisenberg. “Lateral Junction Dynamics
Lead the Way Out.” Nature Cell Biology, vol. 16, no. 2, Nature Publishing
Group, 2014, pp. 127–29, doi:10.1038/ncb2913.
short: M. Behrndt, C.-P.J. Heisenberg, Nature Cell Biology 16 (2014) 127–129.
date_created: 2018-12-11T11:54:37Z
date_published: 2014-01-31T00:00:00Z
date_updated: 2021-01-12T06:53:56Z
day: '31'
department:
- _id: CaHe
doi: 10.1038/ncb2913
intvolume: ' 16'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 127 - 129
publication: Nature Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5195'
quality_controlled: '1'
scopus_import: 1
status: public
title: Lateral junction dynamics lead the way out
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2014'
...
---
_id: '1909'
abstract:
- lang: eng
text: 'Summary: Phenotypes are often environmentally dependent, which requires organisms
to track environmental change. The challenge for organisms is to construct phenotypes
using the most accurate environmental cue. Here, we use a quantitative genetic
model of adaptation by additive genetic variance, within- and transgenerational
plasticity via linear reaction norms and indirect genetic effects respectively.
We show how the relative influence on the eventual phenotype of these components
depends on the predictability of environmental change (fast or slow, sinusoidal
or stochastic) and the developmental lag τ between when the environment is perceived
and when selection acts. We then decompose expected mean fitness into three components
(variance load, adaptation and fluctuation load) to study the fitness costs of
within- and transgenerational plasticity. A strongly negative maternal effect
coefficient m minimizes the variance load, but a strongly positive m minimises
the fluctuation load. The adaptation term is maximized closer to zero, with positive
or negative m preferred under different environmental scenarios. Phenotypic plasticity
is higher when τ is shorter and when the environment changes frequently between
seasonal extremes. Expected mean population fitness is highest away from highest
observed levels of phenotypic plasticity. Within- and transgenerational plasticity
act in concert to deliver well-adapted phenotypes, which emphasizes the need to
study both simultaneously when investigating phenotypic evolution.'
acknowledgement: 'Engineering and Physical Sciences Research Council. Grant Number:
EP/H031928/1'
author:
- first_name: Thomas
full_name: Ezard, Thomas
last_name: Ezard
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
- first_name: Rebecca
full_name: Hoyle, Rebecca
last_name: Hoyle
citation:
ama: Ezard T, Prizak R, Hoyle R. The fitness costs of adaptation via phenotypic
plasticity and maternal effects. Functional Ecology. 2014;28(3):693-701.
doi:10.1111/1365-2435.12207
apa: Ezard, T., Prizak, R., & Hoyle, R. (2014). The fitness costs of adaptation
via phenotypic plasticity and maternal effects. Functional Ecology. Wiley-Blackwell.
https://doi.org/10.1111/1365-2435.12207
chicago: Ezard, Thomas, Roshan Prizak, and Rebecca Hoyle. “The Fitness Costs of
Adaptation via Phenotypic Plasticity and Maternal Effects.” Functional Ecology.
Wiley-Blackwell, 2014. https://doi.org/10.1111/1365-2435.12207.
ieee: T. Ezard, R. Prizak, and R. Hoyle, “The fitness costs of adaptation via phenotypic
plasticity and maternal effects,” Functional Ecology, vol. 28, no. 3. Wiley-Blackwell,
pp. 693–701, 2014.
ista: Ezard T, Prizak R, Hoyle R. 2014. The fitness costs of adaptation via phenotypic
plasticity and maternal effects. Functional Ecology. 28(3), 693–701.
mla: Ezard, Thomas, et al. “The Fitness Costs of Adaptation via Phenotypic Plasticity
and Maternal Effects.” Functional Ecology, vol. 28, no. 3, Wiley-Blackwell,
2014, pp. 693–701, doi:10.1111/1365-2435.12207.
short: T. Ezard, R. Prizak, R. Hoyle, Functional Ecology 28 (2014) 693–701.
date_created: 2018-12-11T11:54:40Z
date_published: 2014-06-01T00:00:00Z
date_updated: 2021-01-12T06:54:00Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1111/1365-2435.12207
file:
- access_level: open_access
checksum: 3cbe8623174709a8ceec2103246f8fe0
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:45Z
date_updated: 2020-07-14T12:45:20Z
file_id: '5167'
file_name: IST-2016-419-v1+1_Ezard_et_al-2014-Functional_Ecology.pdf
file_size: 536154
relation: main_file
file_date_updated: 2020-07-14T12:45:20Z
has_accepted_license: '1'
intvolume: ' 28'
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 693 - 701
publication: Functional Ecology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5186'
pubrep_id: '419'
scopus_import: 1
status: public
title: The fitness costs of adaptation via phenotypic plasticity and maternal effects
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2014'
...
---
_id: '1910'
abstract:
- lang: eng
text: angerhans cells (LCs) are a unique subset of dendritic cells (DCs) that express
epithelial adhesion molecules, allowing them to form contacts with epithelial
cells and reside in epidermal/epithelial tissues. The dynamic regulation of epithelial
adhesion plays a decisive role in the life cycle of LCs. It controls whether LCs
remain immature and sessile within the epidermis or mature and egress to initiate
immune responses. So far, the molecular machinery regulating epithelial adhesion
molecules during LC maturation remains elusive. Here, we generated pure populations
of immature human LCs in vitro to systematically probe for gene-expression changes
during LC maturation. LCs down-regulate a set of epithelial genes including E-cadherin,
while they upregulate the mesenchymal marker N-cadherin known to facilitate cell
migration. In addition, N-cadherin is constitutively expressed by monocyte-derived
DCs known to exhibit characteristics of both inflammatory-type and interstitial/dermal
DCs. Moreover, the transcription factors ZEB1 and ZEB2 (ZEB is zinc-finger E-box-binding
homeobox) are upregulated in migratory LCs. ZEB1 and ZEB2 have been shown to induce
epithelial-to-mesenchymal transition (EMT) and invasive behavior in cancer cells
undergoing metastasis. Our results provide the first hint that the molecular EMT
machinery might facilitate LC mobilization. Moreover, our study suggests that
N-cadherin plays a role during DC migration.
acknowledgement: 'FWF. Grant Number: P22058-B20'
author:
- first_name: Sabine
full_name: Konradi, Sabine
last_name: Konradi
- first_name: Nighat
full_name: Yasmin, Nighat
last_name: Yasmin
- first_name: Denise
full_name: Haslwanter, Denise
last_name: Haslwanter
- first_name: Michele
full_name: Weber, Michele
id: 3A3FC708-F248-11E8-B48F-1D18A9856A87
last_name: Weber
- first_name: Bernd
full_name: Gesslbauer, Bernd
last_name: Gesslbauer
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Herbert
full_name: Strobl, Herbert
last_name: Strobl
citation:
ama: Konradi S, Yasmin N, Haslwanter D, et al. Langerhans cell maturation is accompanied
by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal
transition ZEB1/2. European Journal of Immunology. 2014;44(2):553-560.
doi:10.1002/eji.201343681
apa: Konradi, S., Yasmin, N., Haslwanter, D., Weber, M., Gesslbauer, B., Sixt, M.
K., & Strobl, H. (2014). Langerhans cell maturation is accompanied by induction
of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition
ZEB1/2. European Journal of Immunology. Wiley-Blackwell. https://doi.org/10.1002/eji.201343681
chicago: Konradi, Sabine, Nighat Yasmin, Denise Haslwanter, Michele Weber, Bernd
Gesslbauer, Michael K Sixt, and Herbert Strobl. “Langerhans Cell Maturation Is
Accompanied by Induction of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal
Transition ZEB1/2.” European Journal of Immunology. Wiley-Blackwell, 2014.
https://doi.org/10.1002/eji.201343681.
ieee: S. Konradi et al., “Langerhans cell maturation is accompanied by induction
of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition
ZEB1/2,” European Journal of Immunology, vol. 44, no. 2. Wiley-Blackwell,
pp. 553–560, 2014.
ista: Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt MK, Strobl
H. 2014. Langerhans cell maturation is accompanied by induction of N-cadherin
and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
European Journal of Immunology. 44(2), 553–560.
mla: Konradi, Sabine, et al. “Langerhans Cell Maturation Is Accompanied by Induction
of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal Transition
ZEB1/2.” European Journal of Immunology, vol. 44, no. 2, Wiley-Blackwell,
2014, pp. 553–60, doi:10.1002/eji.201343681.
short: S. Konradi, N. Yasmin, D. Haslwanter, M. Weber, B. Gesslbauer, M.K. Sixt,
H. Strobl, European Journal of Immunology 44 (2014) 553–560.
date_created: 2018-12-11T11:54:40Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2021-01-12T06:54:01Z
day: '01'
department:
- _id: MiSi
doi: 10.1002/eji.201343681
intvolume: ' 44'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 553 - 560
publication: European Journal of Immunology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5185'
scopus_import: 1
status: public
title: Langerhans cell maturation is accompanied by induction of N-cadherin and the
transcriptional regulators of epithelial-mesenchymal transition ZEB1/2
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 44
year: '2014'
...
---
_id: '1907'
abstract:
- lang: eng
text: 'Most cryptographic security proofs require showing that two systems are indistinguishable.
A central tool in such proofs is that of a game, where winning the game means
provoking a certain condition, and it is shown that the two systems considered
cannot be distinguished unless this condition is provoked. Upper bounding the
probability of winning such a game, i.e., provoking this condition, for an arbitrary
strategy is usually hard, except in the special case where the best strategy for
winning such a game is known to be non-adaptive. A sufficient criterion for ensuring
the optimality of non-adaptive strategies is that of conditional equivalence to
a system, a notion introduced in [1]. In this paper, we show that this criterion
is not necessary to ensure the optimality of non-adaptive strategies by giving
two results of independent interest: 1) the optimality of non-adaptive strategies
is not preserved under parallel composition; 2) in contrast, conditional equivalence
is preserved under parallel composition.'
article_number: '6875125'
author:
- first_name: Grégory
full_name: Demay, Grégory
last_name: Demay
- first_name: Peter
full_name: Gazi, Peter
id: 3E0BFE38-F248-11E8-B48F-1D18A9856A87
last_name: Gazi
- first_name: Ueli
full_name: Maurer, Ueli
last_name: Maurer
- first_name: Björn
full_name: Tackmann, Björn
last_name: Tackmann
citation:
ama: 'Demay G, Gazi P, Maurer U, Tackmann B. Optimality of non-adaptive strategies:
The case of parallel games. In: IEEE International Symposium on Information
Theory. IEEE; 2014. doi:10.1109/ISIT.2014.6875125'
apa: 'Demay, G., Gazi, P., Maurer, U., & Tackmann, B. (2014). Optimality of
non-adaptive strategies: The case of parallel games. In IEEE International
Symposium on Information Theory. Honolulu, USA: IEEE. https://doi.org/10.1109/ISIT.2014.6875125'
chicago: 'Demay, Grégory, Peter Gazi, Ueli Maurer, and Björn Tackmann. “Optimality
of Non-Adaptive Strategies: The Case of Parallel Games.” In IEEE International
Symposium on Information Theory. IEEE, 2014. https://doi.org/10.1109/ISIT.2014.6875125.'
ieee: 'G. Demay, P. Gazi, U. Maurer, and B. Tackmann, “Optimality of non-adaptive
strategies: The case of parallel games,” in IEEE International Symposium on
Information Theory, Honolulu, USA, 2014.'
ista: 'Demay G, Gazi P, Maurer U, Tackmann B. 2014. Optimality of non-adaptive strategies:
The case of parallel games. IEEE International Symposium on Information Theory.
IEEE International Symposium on Information Theory Proceedings, 6875125.'
mla: 'Demay, Grégory, et al. “Optimality of Non-Adaptive Strategies: The Case of
Parallel Games.” IEEE International Symposium on Information Theory, 6875125,
IEEE, 2014, doi:10.1109/ISIT.2014.6875125.'
short: G. Demay, P. Gazi, U. Maurer, B. Tackmann, in:, IEEE International Symposium
on Information Theory, IEEE, 2014.
conference:
end_date: 2014-07-04
location: Honolulu, USA
name: IEEE International Symposium on Information Theory Proceedings
start_date: 2014-06-29
date_created: 2018-12-11T11:54:39Z
date_published: 2014-01-01T00:00:00Z
date_updated: 2021-01-12T06:53:59Z
day: '01'
department:
- _id: KrPi
doi: 10.1109/ISIT.2014.6875125
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2014/299
month: '01'
oa: 1
oa_version: Submitted Version
publication: IEEE International Symposium on Information Theory
publication_status: published
publisher: IEEE
publist_id: '5188'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Optimality of non-adaptive strategies: The case of parallel games'
type: conference
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
year: '2014'
...
---
_id: '1908'
abstract:
- lang: eng
text: In large populations, multiple beneficial mutations may be simultaneously
spreading. In asexual populations, these mutations must either arise on the same
background or compete against each other. In sexual populations, recombination
can bring together beneficial alleles from different backgrounds, but tightly
linked alleles may still greatly interfere with each other. We show for well-mixed
populations that when this interference is strong, the genome can be seen as consisting
of many effectively asexual stretches linked together. The rate at which beneficial
alleles fix is thus roughly proportional to the rate of recombination and depends
only logarithmically on the mutation supply and the strength of selection. Our
scaling arguments also allow us to predict, with reasonable accuracy, the fitness
distribution of fixed mutations when the mutational effect sizes are broad. We
focus on the regime in which crossovers occur more frequently than beneficial
mutations, as is likely to be the case for many natural populations.
author:
- first_name: Daniel
full_name: Weissman, Daniel
id: 2D0CE020-F248-11E8-B48F-1D18A9856A87
last_name: Weissman
- first_name: Oskar
full_name: Hallatschek, Oskar
last_name: Hallatschek
citation:
ama: Weissman D, Hallatschek O. The rate of adaptation in large sexual populations
with linear chromosomes. Genetics. 2014;196(4):1167-1183. doi:10.1534/genetics.113.160705
apa: Weissman, D., & Hallatschek, O. (2014). The rate of adaptation in large
sexual populations with linear chromosomes. Genetics. Genetics Society
of America. https://doi.org/10.1534/genetics.113.160705
chicago: Weissman, Daniel, and Oskar Hallatschek. “The Rate of Adaptation in Large
Sexual Populations with Linear Chromosomes.” Genetics. Genetics Society
of America, 2014. https://doi.org/10.1534/genetics.113.160705.
ieee: D. Weissman and O. Hallatschek, “The rate of adaptation in large sexual populations
with linear chromosomes,” Genetics, vol. 196, no. 4. Genetics Society of
America, pp. 1167–1183, 2014.
ista: Weissman D, Hallatschek O. 2014. The rate of adaptation in large sexual populations
with linear chromosomes. Genetics. 196(4), 1167–1183.
mla: Weissman, Daniel, and Oskar Hallatschek. “The Rate of Adaptation in Large Sexual
Populations with Linear Chromosomes.” Genetics, vol. 196, no. 4, Genetics
Society of America, 2014, pp. 1167–83, doi:10.1534/genetics.113.160705.
short: D. Weissman, O. Hallatschek, Genetics 196 (2014) 1167–1183.
date_created: 2018-12-11T11:54:39Z
date_published: 2014-04-01T00:00:00Z
date_updated: 2021-01-12T06:53:59Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.113.160705
ec_funded: 1
intvolume: ' 196'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1307.0737
month: '04'
oa: 1
oa_version: Submitted Version
page: 1167 - 1183
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '5187'
quality_controlled: '1'
scopus_import: 1
status: public
title: The rate of adaptation in large sexual populations with linear chromosomes
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 196
year: '2014'
...
---
_id: '1911'
abstract:
- lang: eng
text: The topological Tverberg theorem has been generalized in several directions
by setting extra restrictions on the Tverberg partitions. Restricted Tverberg
partitions, defined by the idea that certain points cannot be in the same part,
are encoded with graphs. When two points are adjacent in the graph, they are not
in the same part. If the restrictions are too harsh, then the topological Tverberg
theorem fails. The colored Tverberg theorem corresponds to graphs constructed
as disjoint unions of small complete graphs. Hell studied the case of paths and
cycles. In graph theory these partitions are usually viewed as graph colorings.
As explored by Aharoni, Haxell, Meshulam and others there are fundamental connections
between several notions of graph colorings and topological combinatorics. For
ordinary graph colorings it is enough to require that the number of colors q satisfy
q>Δ, where Δ is the maximal degree of the graph. It was proven by the first
author using equivariant topology that if q>Δ 2 then the topological Tverberg
theorem still works. It is conjectured that q>KΔ is also enough for some constant
K, and in this paper we prove a fixed-parameter version of that conjecture. The
required topological connectivity results are proven with shellability, which
also strengthens some previous partial results where the topological connectivity
was proven with the nerve lemma.
acknowledgement: Patrik Norén gratefully acknowledges support from the Wallenberg
foundation
author:
- first_name: Alexander
full_name: Engström, Alexander
last_name: Engström
- first_name: Patrik
full_name: Noren, Patrik
id: 46870C74-F248-11E8-B48F-1D18A9856A87
last_name: Noren
citation:
ama: Engström A, Noren P. Tverberg’s Theorem and Graph Coloring. Discrete &
Computational Geometry. 2014;51(1):207-220. doi:10.1007/s00454-013-9556-3
apa: Engström, A., & Noren, P. (2014). Tverberg’s Theorem and Graph Coloring.
Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-013-9556-3
chicago: Engström, Alexander, and Patrik Noren. “Tverberg’s Theorem and Graph Coloring.”
Discrete & Computational Geometry. Springer, 2014. https://doi.org/10.1007/s00454-013-9556-3.
ieee: A. Engström and P. Noren, “Tverberg’s Theorem and Graph Coloring,” Discrete
& Computational Geometry, vol. 51, no. 1. Springer, pp. 207–220, 2014.
ista: Engström A, Noren P. 2014. Tverberg’s Theorem and Graph Coloring. Discrete
& Computational Geometry. 51(1), 207–220.
mla: Engström, Alexander, and Patrik Noren. “Tverberg’s Theorem and Graph Coloring.”
Discrete & Computational Geometry, vol. 51, no. 1, Springer, 2014,
pp. 207–20, doi:10.1007/s00454-013-9556-3.
short: A. Engström, P. Noren, Discrete & Computational Geometry 51 (2014) 207–220.
date_created: 2018-12-11T11:54:40Z
date_published: 2014-01-01T00:00:00Z
date_updated: 2021-01-12T06:54:01Z
day: '01'
department:
- _id: CaUh
doi: 10.1007/s00454-013-9556-3
intvolume: ' 51'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 207 - 220
publication: Discrete & Computational Geometry
publication_status: published
publisher: Springer
publist_id: '5183'
scopus_import: 1
status: public
title: Tverberg's Theorem and Graph Coloring
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2014'
...
---
_id: '1916'
abstract:
- lang: eng
text: Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron diseases
characterized by progressive age-dependent loss of corticospinal motor tract function.
Although the genetic basis is partly understood, only a fraction of cases can
receive a genetic diagnosis, and a global view of HSP is lacking. By using whole-exome
sequencing in combination with network analysis, we identified 18 previously unknown
putative HSP genes and validated nearly all of these genes functionally or genetically.
The pathways highlighted by these mutations link HSP to cellular transport, nucleotide
metabolism, and synapse and axon development. Network analysis revealed a host
of further candidate genes, of which three were mutated in our cohort. Our analysis
links HSP to other neurodegenerative disorders and can facilitate gene discovery
and mechanistic understanding of disease.
acknowledgement: Supported by the Deutsche Forschungsgemeinschaft (G.N.)
article_processing_charge: No
article_type: original
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Ali
full_name: Fenstermaker, Ali
last_name: Fenstermaker
- first_name: Maha
full_name: Zaki, Maha
last_name: Zaki
- first_name: Matan
full_name: Hofree, Matan
last_name: Hofree
- first_name: Jennifer
full_name: Silhavy, Jennifer
last_name: Silhavy
- first_name: Andrew
full_name: Heiberg, Andrew
last_name: Heiberg
- first_name: Mostafa
full_name: Abdellateef, Mostafa
last_name: Abdellateef
- first_name: Başak
full_name: Rosti, Başak
last_name: Rosti
- first_name: Eric
full_name: Scott, Eric
last_name: Scott
- first_name: Lobna
full_name: Mansour, Lobna
last_name: Mansour
- first_name: Amira
full_name: Masri, Amira
last_name: Masri
- first_name: Hülya
full_name: Kayserili, Hülya
last_name: Kayserili
- first_name: Jumana
full_name: Al Aama, Jumana
last_name: Al Aama
- first_name: Ghada
full_name: Abdel Salam, Ghada
last_name: Abdel Salam
- first_name: Ariana
full_name: Karminejad, Ariana
last_name: Karminejad
- first_name: Majdi
full_name: Kara, Majdi
last_name: Kara
- first_name: Bülent
full_name: Kara, Bülent
last_name: Kara
- first_name: Bita
full_name: Bozorgmehri, Bita
last_name: Bozorgmehri
- first_name: Tawfeg
full_name: Ben Omran, Tawfeg
last_name: Ben Omran
- first_name: Faezeh
full_name: Mojahedi, Faezeh
last_name: Mojahedi
- first_name: Iman
full_name: Mahmoud, Iman
last_name: Mahmoud
- first_name: Naïma
full_name: Bouslam, Naïma
last_name: Bouslam
- first_name: Ahmed
full_name: Bouhouche, Ahmed
last_name: Bouhouche
- first_name: Ali
full_name: Benomar, Ali
last_name: Benomar
- first_name: Sylvain
full_name: Hanein, Sylvain
last_name: Hanein
- first_name: Laure
full_name: Raymond, Laure
last_name: Raymond
- first_name: Sylvie
full_name: Forlani, Sylvie
last_name: Forlani
- first_name: Massimo
full_name: Mascaro, Massimo
last_name: Mascaro
- first_name: Laila
full_name: Selim, Laila
last_name: Selim
- first_name: Nabil
full_name: Shehata, Nabil
last_name: Shehata
- first_name: Nasir
full_name: Al Allawi, Nasir
last_name: Al Allawi
- first_name: Parayil
full_name: Bindu, Parayil
last_name: Bindu
- first_name: Matloob
full_name: Azam, Matloob
last_name: Azam
- first_name: Murat
full_name: Günel, Murat
last_name: Günel
- first_name: Ahmet
full_name: Caglayan, Ahmet
last_name: Caglayan
- first_name: Kaya
full_name: Bilgüvar, Kaya
last_name: Bilgüvar
- first_name: Aslihan
full_name: Tolun, Aslihan
last_name: Tolun
- first_name: Mahmoud
full_name: Issa, Mahmoud
last_name: Issa
- first_name: Jana
full_name: Schroth, Jana
last_name: Schroth
- first_name: Emily
full_name: Spencer, Emily
last_name: Spencer
- first_name: Rasim
full_name: Rosti, Rasim
last_name: Rosti
- first_name: Naiara
full_name: Akizu, Naiara
last_name: Akizu
- first_name: Keith
full_name: Vaux, Keith
last_name: Vaux
- first_name: Anide
full_name: Johansen, Anide
last_name: Johansen
- first_name: Alice
full_name: Koh, Alice
last_name: Koh
- first_name: Hisham
full_name: Megahed, Hisham
last_name: Megahed
- first_name: Alexandra
full_name: Dürr, Alexandra
last_name: Dürr
- first_name: Alexis
full_name: Brice, Alexis
last_name: Brice
- first_name: Giovanni
full_name: Stévanin, Giovanni
last_name: Stévanin
- first_name: Stacy
full_name: Gabriel, Stacy
last_name: Gabriel
- first_name: Trey
full_name: Ideker, Trey
last_name: Ideker
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
citation:
ama: Novarino G, Fenstermaker A, Zaki M, et al. Exome sequencing links corticospinal
motor neuron disease to common neurodegenerative disorders. Science. 2014;343(6170):506-511.
doi:10.1126/science.1247363
apa: Novarino, G., Fenstermaker, A., Zaki, M., Hofree, M., Silhavy, J., Heiberg,
A., … Gleeson, J. (2014). Exome sequencing links corticospinal motor neuron disease
to common neurodegenerative disorders. Science. American Association for
the Advancement of Science. https://doi.org/10.1126/science.1247363
chicago: Novarino, Gaia, Ali Fenstermaker, Maha Zaki, Matan Hofree, Jennifer Silhavy,
Andrew Heiberg, Mostafa Abdellateef, et al. “Exome Sequencing Links Corticospinal
Motor Neuron Disease to Common Neurodegenerative Disorders.” Science. American
Association for the Advancement of Science, 2014. https://doi.org/10.1126/science.1247363.
ieee: G. Novarino et al., “Exome sequencing links corticospinal motor neuron
disease to common neurodegenerative disorders,” Science, vol. 343, no.
6170. American Association for the Advancement of Science, pp. 506–511, 2014.
ista: Novarino G, Fenstermaker A, Zaki M, Hofree M, Silhavy J, Heiberg A, Abdellateef
M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al Aama J, Abdel Salam G,
Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben Omran T, Mojahedi F, Mahmoud
I, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro
M, Selim L, Shehata N, Al Allawi N, Bindu P, Azam M, Günel M, Caglayan A, Bilgüvar
K, Tolun A, Issa M, Schroth J, Spencer E, Rosti R, Akizu N, Vaux K, Johansen A,
Koh A, Megahed H, Dürr A, Brice A, Stévanin G, Gabriel S, Ideker T, Gleeson J.
2014. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative
disorders. Science. 343(6170), 506–511.
mla: Novarino, Gaia, et al. “Exome Sequencing Links Corticospinal Motor Neuron Disease
to Common Neurodegenerative Disorders.” Science, vol. 343, no. 6170, American
Association for the Advancement of Science, 2014, pp. 506–11, doi:10.1126/science.1247363.
short: G. Novarino, A. Fenstermaker, M. Zaki, M. Hofree, J. Silhavy, A. Heiberg,
M. Abdellateef, B. Rosti, E. Scott, L. Mansour, A. Masri, H. Kayserili, J. Al
Aama, G. Abdel Salam, A. Karminejad, M. Kara, B. Kara, B. Bozorgmehri, T. Ben
Omran, F. Mojahedi, I. Mahmoud, N. Bouslam, A. Bouhouche, A. Benomar, S. Hanein,
L. Raymond, S. Forlani, M. Mascaro, L. Selim, N. Shehata, N. Al Allawi, P. Bindu,
M. Azam, M. Günel, A. Caglayan, K. Bilgüvar, A. Tolun, M. Issa, J. Schroth, E.
Spencer, R. Rosti, N. Akizu, K. Vaux, A. Johansen, A. Koh, H. Megahed, A. Dürr,
A. Brice, G. Stévanin, S. Gabriel, T. Ideker, J. Gleeson, Science 343 (2014) 506–511.
date_created: 2018-12-11T11:54:42Z
date_published: 2014-01-31T00:00:00Z
date_updated: 2021-01-12T06:54:03Z
day: '31'
department:
- _id: GaNo
doi: 10.1126/science.1247363
external_id:
pmid:
- '24482476'
intvolume: ' 343'
issue: '6170'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157572/
month: '01'
oa: 1
oa_version: Submitted Version
page: 506 - 511
pmid: 1
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5178'
quality_controlled: '1'
scopus_import: 1
status: public
title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative
disorders
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 343
year: '2014'
...
---
_id: '1917'
abstract:
- lang: eng
text: Auxin-binding protein 1 (ABP1) was discovered nearly 40 years ago and was
shown to be essential for plant development and morphogenesis, but its mode of
action remains unclear. Here, we report that the plasma membrane-localized transmembrane
kinase (TMK) receptor-like kinases interact with ABP1 and transduce auxin signal
to activate plasma membrane-associated ROPs [Rho-like guanosine triphosphatases
(GTPase) from plants], leading to changes in the cytoskeleton and the shape of
leaf pavement cells in Arabidopsis. The interaction between ABP1 and TMK at the
cell surface is induced by auxin and requires ABP1 sensing of auxin. These findings
show that TMK proteins and ABP1 form a cell surface auxin perception complex that
activates ROP signaling pathways, regulating nontranscriptional cytoplasmic responses
and associated fundamental processes.
acknowledgement: Supported by the intramural research program of the National Institute
of Arthritis and Musculoskeletal and Skin Diseases and by its Laboratory Animal
Care and Use Section and Flow Cytometry Group, Office of Science and Technology
article_processing_charge: No
article_type: original
author:
- first_name: Tongda
full_name: Xu, Tongda
last_name: Xu
- first_name: Ning
full_name: Dai, Ning
last_name: Dai
- first_name: Jisheng
full_name: Chen, Jisheng
last_name: Chen
- first_name: Shingo
full_name: Nagawa, Shingo
last_name: Nagawa
- first_name: Min
full_name: Cao, Min
last_name: Cao
- first_name: Hongjiang
full_name: Li, Hongjiang
id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0001-5039-9660
- first_name: Zimin
full_name: Zhou, Zimin
last_name: Zhou
- first_name: Xu
full_name: Chen, Xu
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Riet
full_name: De Rycke, Riet
last_name: De Rycke
- first_name: Hana
full_name: Rakusová, Hana
last_name: Rakusová
- first_name: Wen
full_name: Wang, Wen
last_name: Wang
- first_name: Alan
full_name: Jones, Alan
last_name: Jones
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Sara
full_name: Patterson, Sara
last_name: Patterson
- first_name: Anthony
full_name: Bleecker, Anthony
last_name: Bleecker
- first_name: Zhenbiao
full_name: Yang, Zhenbiao
last_name: Yang
citation:
ama: Xu T, Dai N, Chen J, et al. Cell surface ABP1-TMK auxin sensing complex activates
ROP GTPase signaling. Science. 2014;343(6174):1025-1028. doi:10.1126/science.1245125
apa: Xu, T., Dai, N., Chen, J., Nagawa, S., Cao, M., Li, H., … Yang, Z. (2014).
Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1245125
chicago: Xu, Tongda, Ning Dai, Jisheng Chen, Shingo Nagawa, Min Cao, Hongjiang Li,
Zimin Zhou, et al. “Cell Surface ABP1-TMK Auxin Sensing Complex Activates ROP
GTPase Signaling.” Science. American Association for the Advancement of
Science, 2014. https://doi.org/10.1126/science.1245125.
ieee: T. Xu et al., “Cell surface ABP1-TMK auxin sensing complex activates
ROP GTPase signaling,” Science, vol. 343, no. 6174. American Association
for the Advancement of Science, pp. 1025–1028, 2014.
ista: Xu T, Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, De Rycke R, Rakusová
H, Wang W, Jones A, Friml J, Patterson S, Bleecker A, Yang Z. 2014. Cell surface
ABP1-TMK auxin sensing complex activates ROP GTPase signaling. Science. 343(6174),
1025–1028.
mla: Xu, Tongda, et al. “Cell Surface ABP1-TMK Auxin Sensing Complex Activates ROP
GTPase Signaling.” Science, vol. 343, no. 6174, American Association for
the Advancement of Science, 2014, pp. 1025–28, doi:10.1126/science.1245125.
short: T. Xu, N. Dai, J. Chen, S. Nagawa, M. Cao, H. Li, Z. Zhou, X. Chen, R. De
Rycke, H. Rakusová, W. Wang, A. Jones, J. Friml, S. Patterson, A. Bleecker, Z.
Yang, Science 343 (2014) 1025–1028.
date_created: 2018-12-11T11:54:42Z
date_published: 2014-02-28T00:00:00Z
date_updated: 2021-01-12T06:54:03Z
day: '28'
department:
- _id: JiFr
doi: 10.1126/science.1245125
external_id:
pmid:
- '24578577'
intvolume: ' 343'
issue: '6174'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166562/
month: '02'
oa: 1
oa_version: Submitted Version
page: 1025 - 1028
pmid: 1
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5177'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 343
year: '2014'
...
---
_id: '1920'
abstract:
- lang: eng
text: Cerebellar motor learning is suggested to be caused by long-term plasticity
of excitatory parallel fiber-Purkinje cell (PF-PC) synapses associated with changes
in the number of synaptic AMPA-type glutamate receptors (AMPARs). However, whether
the AMPARs decrease or increase in individual PF-PC synapses occurs in physiological
motor learning and accounts for memory that lasts over days remains elusive. We
combined quantitative SDS-digested freeze-fracture replica labeling for AMPAR
and physical dissector electron microscopy with a simple model of cerebellar motor
learning, adaptation of horizontal optokinetic response (HOKR) in mouse. After
1-h training of HOKR, short-term adaptation (STA) was accompanied with transient
decrease in AMPARs by 28% in target PF-PC synapses. STA was well correlated with
AMPAR decrease in individual animals and both STA and AMPAR decrease recovered
to basal levels within 24 h. Surprisingly, long-termadaptation (LTA) after five
consecutive daily trainings of 1-h HOKR did not alter the number of AMPARs in
PF-PC synapses but caused gradual and persistent synapse elimination by 45%, with
corresponding PC spine loss by the fifth training day. Furthermore, recovery of
LTA after 2 wk was well correlated with increase of PF-PC synapses to the control
level. Our findings indicate that the AMPARs decrease in PF-PC synapses and the
elimination of these synapses are in vivo engrams in short- and long-term motor
learning, respectively, showing a unique type of synaptic plasticity that may
contribute to memory consolidation.
acknowledgement: This work was supported by Solution-Oriented Research for Science
and Technology from the Japan Science and Technology Agency; Ministry of Education,
Culture, Sports, Science and Technology of Japan Grant 16300114 (to R.S.).
author:
- first_name: Wen
full_name: Wang, Wen
last_name: Wang
- first_name: Kazuhiko
full_name: Nakadate, Kazuhiko
last_name: Nakadate
- first_name: Miwako
full_name: Masugi Tokita, Miwako
last_name: Masugi Tokita
- first_name: Fumihiro
full_name: Shutoh, Fumihiro
last_name: Shutoh
- first_name: Wajeeha
full_name: Aziz, Wajeeha
last_name: Aziz
- first_name: Etsuko
full_name: Tarusawa, Etsuko
last_name: Tarusawa
- first_name: Andrea
full_name: Lörincz, Andrea
last_name: Lörincz
- first_name: Elek
full_name: Molnár, Elek
last_name: Molnár
- first_name: Sebnem
full_name: Kesaf, Sebnem
id: 401AB46C-F248-11E8-B48F-1D18A9856A87
last_name: Kesaf
- first_name: Yunqing
full_name: Li, Yunqing
last_name: Li
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Soichi
full_name: Nagao, Soichi
last_name: Nagao
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Wang W, Nakadate K, Masugi Tokita M, et al. Distinct cerebellar engrams in
short-term and long-term motor learning. PNAS. 2014;111(1):E188-E193. doi:10.1073/pnas.1315541111
apa: Wang, W., Nakadate, K., Masugi Tokita, M., Shutoh, F., Aziz, W., Tarusawa,
E., … Shigemoto, R. (2014). Distinct cerebellar engrams in short-term and long-term
motor learning. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1315541111
chicago: Wang, Wen, Kazuhiko Nakadate, Miwako Masugi Tokita, Fumihiro Shutoh, Wajeeha
Aziz, Etsuko Tarusawa, Andrea Lörincz, et al. “Distinct Cerebellar Engrams in
Short-Term and Long-Term Motor Learning.” PNAS. National Academy of Sciences,
2014. https://doi.org/10.1073/pnas.1315541111.
ieee: W. Wang et al., “Distinct cerebellar engrams in short-term and long-term
motor learning,” PNAS, vol. 111, no. 1. National Academy of Sciences, pp.
E188–E193, 2014.
ista: Wang W, Nakadate K, Masugi Tokita M, Shutoh F, Aziz W, Tarusawa E, Lörincz
A, Molnár E, Kesaf S, Li Y, Fukazawa Y, Nagao S, Shigemoto R. 2014. Distinct cerebellar
engrams in short-term and long-term motor learning. PNAS. 111(1), E188–E193.
mla: Wang, Wen, et al. “Distinct Cerebellar Engrams in Short-Term and Long-Term
Motor Learning.” PNAS, vol. 111, no. 1, National Academy of Sciences, 2014,
pp. E188–93, doi:10.1073/pnas.1315541111.
short: W. Wang, K. Nakadate, M. Masugi Tokita, F. Shutoh, W. Aziz, E. Tarusawa,
A. Lörincz, E. Molnár, S. Kesaf, Y. Li, Y. Fukazawa, S. Nagao, R. Shigemoto, PNAS
111 (2014) E188–E193.
date_created: 2018-12-11T11:54:43Z
date_published: 2014-01-07T00:00:00Z
date_updated: 2021-01-12T06:54:05Z
day: '07'
department:
- _id: RySh
doi: 10.1073/pnas.1315541111
intvolume: ' 111'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890858/
month: '01'
oa: 1
oa_version: Submitted Version
page: E188 - E193
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5174'
scopus_import: 1
status: public
title: Distinct cerebellar engrams in short-term and long-term motor learning
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 111
year: '2014'
...
---
_id: '1915'
abstract:
- lang: eng
text: ROPs (Rho of plants) belong to a large family of plant-specific Rho-like small
GTPases that function as essential molecular switches to control diverse cellular
processes including cytoskeleton organization, cell polarization, cytokinesis,
cell differentiation and vesicle trafficking. Although the machineries of vesicle
trafficking and cell polarity in plants have been individually well addressed,
how ROPs co-ordinate those processes is still largely unclear. Recent progress
has been made towards an understanding of the coordination of ROP signalling and
trafficking of PIN (PINFORMED) transporters for the plant hormone auxin in both
root and leaf pavement cells. PIN transporters constantly shuttle between the
endosomal compartments and the polar plasma membrane domains, therefore the modulation
of PIN-dependent auxin transport between cells is a main developmental output
of ROP-regulated vesicle trafficking. The present review focuses on these cellular
mechanisms, especially the integration of ROP-based vesicle trafficking and plant
cell polarity.
acknowledgement: This work was supported by the European Research Council [project
ERC-2011-StG-20101109-PSDP], Central European Institute of Technology (CEITEC) [grant
number CZ.1.05/1.1.00/02.0068], European Social Fund [grant number CZ.1.07/2.3.00/20.0043]
and the Czec
article_processing_charge: No
article_type: original
author:
- first_name: Xu
full_name: Chen, Xu
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Chen X, Friml J. Rho-GTPase-regulated vesicle trafficking in plant cell polarity.
Biochemical Society Transactions. 2014;42(1):212-218. doi:10.1042/BST20130269
apa: Chen, X., & Friml, J. (2014). Rho-GTPase-regulated vesicle trafficking
in plant cell polarity. Biochemical Society Transactions. Portland Press.
https://doi.org/10.1042/BST20130269
chicago: Chen, Xu, and Jiří Friml. “Rho-GTPase-Regulated Vesicle Trafficking in
Plant Cell Polarity.” Biochemical Society Transactions. Portland Press,
2014. https://doi.org/10.1042/BST20130269.
ieee: X. Chen and J. Friml, “Rho-GTPase-regulated vesicle trafficking in plant cell
polarity,” Biochemical Society Transactions, vol. 42, no. 1. Portland Press,
pp. 212–218, 2014.
ista: Chen X, Friml J. 2014. Rho-GTPase-regulated vesicle trafficking in plant cell
polarity. Biochemical Society Transactions. 42(1), 212–218.
mla: Chen, Xu, and Jiří Friml. “Rho-GTPase-Regulated Vesicle Trafficking in Plant
Cell Polarity.” Biochemical Society Transactions, vol. 42, no. 1, Portland
Press, 2014, pp. 212–18, doi:10.1042/BST20130269.
short: X. Chen, J. Friml, Biochemical Society Transactions 42 (2014) 212–218.
date_created: 2018-12-11T11:54:41Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2022-06-07T11:20:56Z
day: '01'
department:
- _id: JiFr
doi: 10.1042/BST20130269
ec_funded: 1
external_id:
pmid:
- '24450654'
intvolume: ' 42'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 212 - 218
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Biochemical Society Transactions
publication_identifier:
eissn:
- 1470-8752
issn:
- 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5179'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rho-GTPase-regulated vesicle trafficking in plant cell polarity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2014'
...
---
_id: '1919'
abstract:
- lang: eng
text: Long-lasting memories are formed when the stimulus is temporally distributed
(spacing effect). However, the synaptic mechanisms underlying this robust phenomenon
and the precise time course of the synaptic modifications that occur during learning
remain unclear. Here we examined the adaptation of horizontal optokinetic response
in mice that underwent 1 h of massed and spaced training at varying intervals.
Despite similar acquisition by all training protocols, 1 h of spacing produced
the highest memory retention at 24 h, which lasted for 1 mo. The distinct kinetics
of memory are strongly correlated with the reduction of floccular parallel fiber-Purkinje
cell synapses but not with AMPA receptor (AMPAR) number and synapse size. After
the spaced training, we observed 25%, 23%, and 12% reduction in AMPAR density,
synapse size, and synapse number, respectively. Four hours after the spaced training,
half of the synapses and Purkinje cell spines had been eliminated, whereas AMPAR
density and synapse size were recovered in remaining synapses. Surprisingly, massed
training also produced long-term memory and halving of synapses; however, this
occurred slowly over days, and the memory lasted for only 1 wk. This distinct
kinetics of structural plasticity may serve as a basis for unique temporal profiles
in the formation and decay of memory with or without intervals.
acknowledgement: his work was supported by Solution Oriented Research for Science
and Technology (R.S.), Core Research for Evolutional Science and Technology, Japan
Science and Technology Agency (Y.F.), and Grants-in-Aid for Scientific Research
on Priority Areas-Molecular Brain Sciences 16300114 (to R.S.) and 18022043 (to Y.F.).
author:
- first_name: Wajeeha
full_name: Aziz, Wajeeha
last_name: Aziz
- first_name: Wen
full_name: Wang, Wen
last_name: Wang
- first_name: Sebnem
full_name: Kesaf, Sebnem
id: 401AB46C-F248-11E8-B48F-1D18A9856A87
last_name: Kesaf
- first_name: Alsayed
full_name: Mohamed, Alsayed
last_name: Mohamed
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Aziz W, Wang W, Kesaf S, Mohamed A, Fukazawa Y, Shigemoto R. Distinct kinetics
of synaptic structural plasticity, memory formation, and memory decay in massed
and spaced learning. PNAS. 2014;111(1):E194-E202. doi:10.1073/pnas.1303317110
apa: Aziz, W., Wang, W., Kesaf, S., Mohamed, A., Fukazawa, Y., & Shigemoto,
R. (2014). Distinct kinetics of synaptic structural plasticity, memory formation,
and memory decay in massed and spaced learning. PNAS. National Academy
of Sciences. https://doi.org/10.1073/pnas.1303317110
chicago: Aziz, Wajeeha, Wen Wang, Sebnem Kesaf, Alsayed Mohamed, Yugo Fukazawa,
and Ryuichi Shigemoto. “Distinct Kinetics of Synaptic Structural Plasticity, Memory
Formation, and Memory Decay in Massed and Spaced Learning.” PNAS. National
Academy of Sciences, 2014. https://doi.org/10.1073/pnas.1303317110.
ieee: W. Aziz, W. Wang, S. Kesaf, A. Mohamed, Y. Fukazawa, and R. Shigemoto, “Distinct
kinetics of synaptic structural plasticity, memory formation, and memory decay
in massed and spaced learning,” PNAS, vol. 111, no. 1. National Academy
of Sciences, pp. E194–E202, 2014.
ista: Aziz W, Wang W, Kesaf S, Mohamed A, Fukazawa Y, Shigemoto R. 2014. Distinct
kinetics of synaptic structural plasticity, memory formation, and memory decay
in massed and spaced learning. PNAS. 111(1), E194–E202.
mla: Aziz, Wajeeha, et al. “Distinct Kinetics of Synaptic Structural Plasticity,
Memory Formation, and Memory Decay in Massed and Spaced Learning.” PNAS,
vol. 111, no. 1, National Academy of Sciences, 2014, pp. E194–202, doi:10.1073/pnas.1303317110.
short: W. Aziz, W. Wang, S. Kesaf, A. Mohamed, Y. Fukazawa, R. Shigemoto, PNAS 111
(2014) E194–E202.
date_created: 2018-12-11T11:54:43Z
date_published: 2014-01-07T00:00:00Z
date_updated: 2021-01-12T06:54:04Z
day: '07'
department:
- _id: RySh
doi: 10.1073/pnas.1303317110
intvolume: ' 111'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890840/
month: '01'
oa: 1
oa_version: Submitted Version
page: E194 - E202
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5175'
scopus_import: 1
status: public
title: Distinct kinetics of synaptic structural plasticity, memory formation, and
memory decay in massed and spaced learning
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 111
year: '2014'
...
---
_id: '1918'
abstract:
- lang: eng
text: As the nuclear charge Z is continuously decreased an N-electron atom undergoes
a binding-unbinding transition. We investigate whether the electrons remain bound
and whether the radius of the system stays finite as the critical value Zc is
approached. Existence of a ground state at Zc is shown under the condition Zc
< N-K, where K is the maximal number of electrons that can be removed at Zc
without changing the energy.
article_number: '1350021'
author:
- first_name: Jacopo
full_name: Bellazzini, Jacopo
last_name: Bellazzini
- first_name: Rupert
full_name: Frank, Rupert
last_name: Frank
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Bellazzini J, Frank R, Lieb É, Seiringer R. Existence of ground states for
negative ions at the binding threshold. Reviews in Mathematical Physics.
2014;26(1). doi:10.1142/S0129055X13500219
apa: Bellazzini, J., Frank, R., Lieb, É., & Seiringer, R. (2014). Existence
of ground states for negative ions at the binding threshold. Reviews in Mathematical
Physics. World Scientific Publishing. https://doi.org/10.1142/S0129055X13500219
chicago: Bellazzini, Jacopo, Rupert Frank, Élliott Lieb, and Robert Seiringer. “Existence
of Ground States for Negative Ions at the Binding Threshold.” Reviews in Mathematical
Physics. World Scientific Publishing, 2014. https://doi.org/10.1142/S0129055X13500219.
ieee: J. Bellazzini, R. Frank, É. Lieb, and R. Seiringer, “Existence of ground states
for negative ions at the binding threshold,” Reviews in Mathematical Physics,
vol. 26, no. 1. World Scientific Publishing, 2014.
ista: Bellazzini J, Frank R, Lieb É, Seiringer R. 2014. Existence of ground states
for negative ions at the binding threshold. Reviews in Mathematical Physics. 26(1),
1350021.
mla: Bellazzini, Jacopo, et al. “Existence of Ground States for Negative Ions at
the Binding Threshold.” Reviews in Mathematical Physics, vol. 26, no. 1,
1350021, World Scientific Publishing, 2014, doi:10.1142/S0129055X13500219.
short: J. Bellazzini, R. Frank, É. Lieb, R. Seiringer, Reviews in Mathematical Physics
26 (2014).
date_created: 2018-12-11T11:54:42Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2021-01-12T06:54:04Z
day: '01'
department:
- _id: RoSe
doi: 10.1142/S0129055X13500219
intvolume: ' 26'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1301.5370
month: '02'
oa: 1
oa_version: Submitted Version
project:
- _id: 26450934-B435-11E9-9278-68D0E5697425
name: NSERC Postdoctoral fellowship
publication: Reviews in Mathematical Physics
publication_status: published
publisher: World Scientific Publishing
publist_id: '5176'
quality_controlled: '1'
scopus_import: 1
status: public
title: Existence of ground states for negative ions at the binding threshold
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2014'
...
---
_id: '1914'
abstract:
- lang: eng
text: Targeting membrane proteins for degradation requires the sequential action
of ESCRT sub-complexes ESCRT-0 to ESCRT-III. Although this machinery is generally
conserved among kingdoms, plants lack the essential ESCRT-0 components. A new
report closes this gap by identifying a novel protein family that substitutes
for ESCRT-0 function in plants.
author:
- first_name: Michael
full_name: Sauer, Michael
last_name: Sauer
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: 'Sauer M, Friml J. Plant biology: Gatekeepers of the road to protein perdition.
Current Biology. 2014;24(1):R27-R29. doi:10.1016/j.cub.2013.11.019'
apa: 'Sauer, M., & Friml, J. (2014). Plant biology: Gatekeepers of the road
to protein perdition. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2013.11.019'
chicago: 'Sauer, Michael, and Jiří Friml. “Plant Biology: Gatekeepers of the Road
to Protein Perdition.” Current Biology. Cell Press, 2014. https://doi.org/10.1016/j.cub.2013.11.019.'
ieee: 'M. Sauer and J. Friml, “Plant biology: Gatekeepers of the road to protein
perdition,” Current Biology, vol. 24, no. 1. Cell Press, pp. R27–R29, 2014.'
ista: 'Sauer M, Friml J. 2014. Plant biology: Gatekeepers of the road to protein
perdition. Current Biology. 24(1), R27–R29.'
mla: 'Sauer, Michael, and Jiří Friml. “Plant Biology: Gatekeepers of the Road to
Protein Perdition.” Current Biology, vol. 24, no. 1, Cell Press, 2014,
pp. R27–29, doi:10.1016/j.cub.2013.11.019.'
short: M. Sauer, J. Friml, Current Biology 24 (2014) R27–R29.
date_created: 2018-12-11T11:54:41Z
date_published: 2014-01-06T00:00:00Z
date_updated: 2021-01-12T06:54:02Z
day: '06'
department:
- _id: JiFr
doi: 10.1016/j.cub.2013.11.019
intvolume: ' 24'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: R27 - R29
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '5180'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Plant biology: Gatekeepers of the road to protein perdition'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2014'
...
---
_id: '1925'
abstract:
- lang: eng
text: In the past decade carbon nanotubes (CNTs) have been widely studied as a potential
drug-delivery system, especially with functionality for cellular targeting. Yet,
little is known about the actual process of docking to cell receptors and transport
dynamics after internalization. Here we performed single-particle studies of folic
acid (FA) mediated CNT binding to human carcinoma cells and their transport inside
the cytosol. In particular, we employed molecular recognition force spectroscopy,
an atomic force microscopy based method, to visualize and quantify docking of
FA functionalized CNTs to FA binding receptors in terms of binding probability
and binding force. We then traced individual fluorescently labeled, FA functionalized
CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed
trajectories of directed diffusion and areas of nanotube confinement in the cytosol.
Our results demonstrate the potential of a single-molecule approach for investigation
of drug-delivery vehicles and their targeting capacity.
acknowledgement: "This work was supported by EC grant Marie Curie RTN-CT-2006-035616,
CARBIO 'Carbon nanotubes for biomedical applications' and Austrian FFG grant mnt-era.net
823980, 'IntelliTip'.\r\n"
article_number: '125704'
article_processing_charge: No
article_type: original
author:
- first_name: Constanze
full_name: Lamprecht, Constanze
last_name: Lamprecht
- first_name: Birgit
full_name: Plochberger, Birgit
last_name: Plochberger
- first_name: Verena
full_name: Ruprecht, Verena
id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
last_name: Ruprecht
orcid: 0000-0003-4088-8633
- first_name: Stefan
full_name: Wieser, Stefan
id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
last_name: Wieser
orcid: 0000-0002-2670-2217
- first_name: Christian
full_name: Rankl, Christian
last_name: Rankl
- first_name: Elena
full_name: Heister, Elena
last_name: Heister
- first_name: Barbara
full_name: Unterauer, Barbara
last_name: Unterauer
- first_name: Mario
full_name: Brameshuber, Mario
last_name: Brameshuber
- first_name: Jürgen
full_name: Danzberger, Jürgen
last_name: Danzberger
- first_name: Petar
full_name: Lukanov, Petar
last_name: Lukanov
- first_name: Emmanuel
full_name: Flahaut, Emmanuel
last_name: Flahaut
- first_name: Gerhard
full_name: Schütz, Gerhard
last_name: Schütz
- first_name: Peter
full_name: Hinterdorfer, Peter
last_name: Hinterdorfer
- first_name: Andreas
full_name: Ebner, Andreas
last_name: Ebner
citation:
ama: Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to
explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology.
2014;25(12). doi:10.1088/0957-4484/25/12/125704
apa: Lamprecht, C., Plochberger, B., Ruprecht, V., Wieser, S., Rankl, C., Heister,
E., … Ebner, A. (2014). A single-molecule approach to explore binding uptake and
transport of cancer cell targeting nanotubes. Nanotechnology. IOP Publishing.
https://doi.org/10.1088/0957-4484/25/12/125704
chicago: Lamprecht, Constanze, Birgit Plochberger, Verena Ruprecht, Stefan Wieser,
Christian Rankl, Elena Heister, Barbara Unterauer, et al. “A Single-Molecule Approach
to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” Nanotechnology.
IOP Publishing, 2014. https://doi.org/10.1088/0957-4484/25/12/125704.
ieee: C. Lamprecht et al., “A single-molecule approach to explore binding
uptake and transport of cancer cell targeting nanotubes,” Nanotechnology,
vol. 25, no. 12. IOP Publishing, 2014.
ista: Lamprecht C, Plochberger B, Ruprecht V, Wieser S, Rankl C, Heister E, Unterauer
B, Brameshuber M, Danzberger J, Lukanov P, Flahaut E, Schütz G, Hinterdorfer P,
Ebner A. 2014. A single-molecule approach to explore binding uptake and transport
of cancer cell targeting nanotubes. Nanotechnology. 25(12), 125704.
mla: Lamprecht, Constanze, et al. “A Single-Molecule Approach to Explore Binding
Uptake and Transport of Cancer Cell Targeting Nanotubes.” Nanotechnology,
vol. 25, no. 12, 125704, IOP Publishing, 2014, doi:10.1088/0957-4484/25/12/125704.
short: C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister,
B. Unterauer, M. Brameshuber, J. Danzberger, P. Lukanov, E. Flahaut, G. Schütz,
P. Hinterdorfer, A. Ebner, Nanotechnology 25 (2014).
date_created: 2018-12-11T11:54:45Z
date_published: 2014-03-28T00:00:00Z
date_updated: 2021-01-12T06:54:07Z
day: '28'
ddc:
- '570'
department:
- _id: CaHe
- _id: MiSi
doi: 10.1088/0957-4484/25/12/125704
file:
- access_level: open_access
checksum: df4e03d225a19179e7790f6d87a12332
content_type: application/pdf
creator: dernst
date_created: 2020-05-15T09:21:19Z
date_updated: 2020-07-14T12:45:21Z
file_id: '7856'
file_name: 2014_Nanotechnology_Lamprecht.pdf
file_size: 3804152
relation: main_file
file_date_updated: 2020-07-14T12:45:21Z
has_accepted_license: '1'
intvolume: ' 25'
issue: '12'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
publication: Nanotechnology
publication_status: published
publisher: IOP Publishing
publist_id: '5169'
scopus_import: 1
status: public
title: A single-molecule approach to explore binding uptake and transport of cancer
cell targeting nanotubes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2014'
...