---
_id: '1666'
abstract:
- lang: eng
text: Evolution of gene regulation is crucial for our understanding of the phenotypic
differences between species, populations and individuals. Sequence-specific binding
of transcription factors to the regulatory regions on the DNA is a key regulatory
mechanism that determines gene expression and hence heritable phenotypic variation.
We use a biophysical model for directional selection on gene expression to estimate
the rates of gain and loss of transcription factor binding sites (TFBS) in finite
populations under both point and insertion/deletion mutations. Our results show
that these rates are typically slow for a single TFBS in an isolated DNA region,
unless the selection is extremely strong. These rates decrease drastically with
increasing TFBS length or increasingly specific protein-DNA interactions, making
the evolution of sites longer than ∼ 10 bp unlikely on typical eukaryotic speciation
timescales. Similarly, evolution converges to the stationary distribution of binding
sequences very slowly, making the equilibrium assumption questionable. The availability
of longer regulatory sequences in which multiple binding sites can evolve simultaneously,
the presence of “pre-sites” or partially decayed old sites in the initial sequence,
and biophysical cooperativity between transcription factors, can all facilitate
gain of TFBS and reconcile theoretical calculations with timescales inferred from
comparative genomics.
author:
- first_name: Murat
full_name: Tugrul, Murat
id: 37C323C6-F248-11E8-B48F-1D18A9856A87
last_name: Tugrul
orcid: 0000-0002-8523-0758
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
citation:
ama: Tugrul M, Paixao T, Barton NH, Tkačik G. Dynamics of transcription factor binding
site evolution. PLoS Genetics. 2015;11(11). doi:10.1371/journal.pgen.1005639
apa: Tugrul, M., Paixao, T., Barton, N. H., & Tkačik, G. (2015). Dynamics of
transcription factor binding site evolution. PLoS Genetics. Public Library
of Science. https://doi.org/10.1371/journal.pgen.1005639
chicago: Tugrul, Murat, Tiago Paixao, Nicholas H Barton, and Gašper Tkačik. “Dynamics
of Transcription Factor Binding Site Evolution.” PLoS Genetics. Public
Library of Science, 2015. https://doi.org/10.1371/journal.pgen.1005639.
ieee: M. Tugrul, T. Paixao, N. H. Barton, and G. Tkačik, “Dynamics of transcription
factor binding site evolution,” PLoS Genetics, vol. 11, no. 11. Public
Library of Science, 2015.
ista: Tugrul M, Paixao T, Barton NH, Tkačik G. 2015. Dynamics of transcription factor
binding site evolution. PLoS Genetics. 11(11).
mla: Tugrul, Murat, et al. “Dynamics of Transcription Factor Binding Site Evolution.”
PLoS Genetics, vol. 11, no. 11, Public Library of Science, 2015, doi:10.1371/journal.pgen.1005639.
short: M. Tugrul, T. Paixao, N.H. Barton, G. Tkačik, PLoS Genetics 11 (2015).
date_created: 2018-12-11T11:53:21Z
date_published: 2015-11-06T00:00:00Z
date_updated: 2023-09-07T11:53:49Z
day: '06'
ddc:
- '576'
department:
- _id: NiBa
- _id: CaGu
- _id: GaTk
doi: 10.1371/journal.pgen.1005639
ec_funded: 1
file:
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checksum: a4e72fca5ccf40ddacf4d08c8e46b554
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:07:58Z
date_updated: 2020-07-14T12:45:10Z
file_id: '4657'
file_name: IST-2016-463-v1+1_journal.pgen.1005639.pdf
file_size: 2580778
relation: main_file
file_date_updated: 2020-07-14T12:45:10Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '5483'
pubrep_id: '463'
quality_controlled: '1'
related_material:
record:
- id: '9712'
relation: research_data
status: public
- id: '1131'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Dynamics of transcription factor binding site evolution
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2015'
...
---
_id: '1502'
abstract:
- lang: eng
text: We extend the theory of input-output conformance with operators for merge
and quotient. The former is useful when testing against multiple requirements
or views. The latter can be used to generate tests for patches of an already tested
system. Both operators can combine systems with different action alphabets, which
is usually the case when constructing complex systems and specifications from
parts, for instance different views as well as newly defined functionality of
a~previous version of the system.
acknowledgement: "This research was funded in part by the European Research Council
(ERC) under grant agreement 267989 (QUAREM), by the Austrian Science Fund (FWF)
projects S11402-N23(RiSE) and Z211-N23 (Wittgestein Award), by People Programme
(Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement 291734, and by the ARTEMIS JU under grant agreement 295373
(nSafeCer). Jan Křetínský has been partially supported by the Czech Science Foundation,
grant No. P202/12/G061. Nikola Beneš has been supported by the\r\nMEYS project
No. CZ.1.07/2.3.00/30.0009 Employment of Newly Graduated Doctors of Science for
Scientific Excellence."
alternative_title:
- 'Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
Software Engineering '
author:
- first_name: Nikola
full_name: Beneš, Nikola
last_name: Beneš
- first_name: Przemyslaw
full_name: Daca, Przemyslaw
id: 49351290-F248-11E8-B48F-1D18A9856A87
last_name: Daca
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Kretinsky, Jan
id: 44CEF464-F248-11E8-B48F-1D18A9856A87
last_name: Kretinsky
orcid: 0000-0002-8122-2881
- first_name: Dejan
full_name: Nickovic, Dejan
last_name: Nickovic
citation:
ama: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. Complete composition
operators for IOCO-testing theory. In: ACM; 2015:101-110. doi:10.1145/2737166.2737175'
apa: 'Beneš, N., Daca, P., Henzinger, T. A., Kretinsky, J., & Nickovic, D. (2015).
Complete composition operators for IOCO-testing theory (pp. 101–110). Presented
at the CBSE: Component-Based Software Engineering , Montreal, QC, Canada: ACM.
https://doi.org/10.1145/2737166.2737175'
chicago: Beneš, Nikola, Przemyslaw Daca, Thomas A Henzinger, Jan Kretinsky, and
Dejan Nickovic. “Complete Composition Operators for IOCO-Testing Theory,” 101–10.
ACM, 2015. https://doi.org/10.1145/2737166.2737175.
ieee: 'N. Beneš, P. Daca, T. A. Henzinger, J. Kretinsky, and D. Nickovic, “Complete
composition operators for IOCO-testing theory,” presented at the CBSE: Component-Based
Software Engineering , Montreal, QC, Canada, 2015, pp. 101–110.'
ista: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. 2015. Complete composition
operators for IOCO-testing theory. CBSE: Component-Based Software Engineering
, Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
Software Engineering , , 101–110.'
mla: Beneš, Nikola, et al. Complete Composition Operators for IOCO-Testing Theory.
ACM, 2015, pp. 101–10, doi:10.1145/2737166.2737175.
short: N. Beneš, P. Daca, T.A. Henzinger, J. Kretinsky, D. Nickovic, in:, ACM, 2015,
pp. 101–110.
conference:
end_date: 2015-05-08
location: Montreal, QC, Canada
name: 'CBSE: Component-Based Software Engineering '
start_date: 2015-05-04
date_created: 2018-12-11T11:52:24Z
date_published: 2015-05-01T00:00:00Z
date_updated: 2023-09-07T11:58:33Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1145/2737166.2737175
ec_funded: 1
file:
- access_level: open_access
checksum: c6ce681035c163a158751f240cb7d389
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:46Z
date_updated: 2020-07-14T12:44:59Z
file_id: '5303'
file_name: IST-2016-625-v1+1_conf-cbse-BenesDHKN15.pdf
file_size: 467561
relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 101 - 110
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_identifier:
isbn:
- 978-1-4503-3471-6
publication_status: published
publisher: ACM
publist_id: '5676'
pubrep_id: '625'
quality_controlled: '1'
related_material:
record:
- id: '1155'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Complete composition operators for IOCO-testing theory
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1501'
abstract:
- lang: eng
text: 'We consider Markov decision processes (MDPs) which are a standard model for
probabilistic systems. We focus on qualitative properties for MDPs that can express
that desired behaviors of the system arise almost-surely (with probability 1)
or with positive probability. We introduce a new simulation relation to capture
the refinement relation of MDPs with respect to qualitative properties, and present
discrete graph algorithms with quadratic complexity to compute the simulation
relation. We present an automated technique for assume-guarantee style reasoning
for compositional analysis of two-player games by giving a counterexample guided
abstraction-refinement approach to compute our new simulation relation. We show
a tight link between two-player games and MDPs, and as a consequence the results
for games are lifted to MDPs with qualitative properties. We have implemented
our algorithms and show that the compositional analysis leads to significant improvements. '
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
Grant No. P23499- N23, FWF NFN Grant No. S11407-N23, FWF Grant S11403-N23 (RiSE),
and FWF Grant Z211-N23 (Wittgenstein Award), ERC Start Grant (279307: Graph Games),
Microsoft faculty fellows award, the ERC Advanced Grant QUAREM (Quantitative Reactive
Modeling).'
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Chmelik, Martin
id: 3624234E-F248-11E8-B48F-1D18A9856A87
last_name: Chmelik
- first_name: Przemyslaw
full_name: Daca, Przemyslaw
id: 49351290-F248-11E8-B48F-1D18A9856A87
last_name: Daca
citation:
ama: Chatterjee K, Chmelik M, Daca P. CEGAR for compositional analysis of qualitative
properties in Markov decision processes. Formal Methods in System Design.
2015;47(2):230-264. doi:10.1007/s10703-015-0235-2
apa: Chatterjee, K., Chmelik, M., & Daca, P. (2015). CEGAR for compositional
analysis of qualitative properties in Markov decision processes. Formal Methods
in System Design. Springer. https://doi.org/10.1007/s10703-015-0235-2
chicago: Chatterjee, Krishnendu, Martin Chmelik, and Przemyslaw Daca. “CEGAR for
Compositional Analysis of Qualitative Properties in Markov Decision Processes.”
Formal Methods in System Design. Springer, 2015. https://doi.org/10.1007/s10703-015-0235-2.
ieee: K. Chatterjee, M. Chmelik, and P. Daca, “CEGAR for compositional analysis
of qualitative properties in Markov decision processes,” Formal Methods in
System Design, vol. 47, no. 2. Springer, pp. 230–264, 2015.
ista: Chatterjee K, Chmelik M, Daca P. 2015. CEGAR for compositional analysis of
qualitative properties in Markov decision processes. Formal Methods in System
Design. 47(2), 230–264.
mla: Chatterjee, Krishnendu, et al. “CEGAR for Compositional Analysis of Qualitative
Properties in Markov Decision Processes.” Formal Methods in System Design,
vol. 47, no. 2, Springer, 2015, pp. 230–64, doi:10.1007/s10703-015-0235-2.
short: K. Chatterjee, M. Chmelik, P. Daca, Formal Methods in System Design 47 (2015)
230–264.
date_created: 2018-12-11T11:52:23Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2023-09-07T11:58:33Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1007/s10703-015-0235-2
ec_funded: 1
intvolume: ' 47'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1405.0835
month: '10'
oa: 1
oa_version: Preprint
page: 230 - 264
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '5677'
quality_controlled: '1'
related_material:
record:
- id: '1155'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: CEGAR for compositional analysis of qualitative properties in Markov decision
processes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2015'
...
---
_id: '1602'
abstract:
- lang: eng
text: Interprocedural analysis is at the heart of numerous applications in programming
languages, such as alias analysis, constant propagation, etc. Recursive state
machines (RSMs) are standard models for interprocedural analysis. We consider
a general framework with RSMs where the transitions are labeled from a semiring,
and path properties are algebraic with semiring operations. RSMs with algebraic
path properties can model interprocedural dataflow analysis problems, the shortest
path problem, the most probable path problem, etc. The traditional algorithms
for interprocedural analysis focus on path properties where the starting point
is fixed as the entry point of a specific method. In this work, we consider possible
multiple queries as required in many applications such as in alias analysis. The
study of multiple queries allows us to bring in a very important algorithmic distinction
between the resource usage of the one-time preprocessing vs for each individual
query. The second aspect that we consider is that the control flow graphs for
most programs have constant treewidth. Our main contributions are simple and implementable
algorithms that supportmultiple queries for algebraic path properties for RSMs
that have constant treewidth. Our theoretical results show that our algorithms
have small additional one-time preprocessing, but can answer subsequent queries
significantly faster as compared to the current best-known solutions for several
important problems, such as interprocedural reachability and shortest path. We
provide a prototype implementation for interprocedural reachability and intraprocedural
shortest path that gives a significant speed-up on several benchmarks.
acknowledgement: We thank anonymous reviewers for helpful comments to improve the
presentation of the paper.
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Prateesh
full_name: Goyal, Prateesh
last_name: Goyal
citation:
ama: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A, Goyal P. Faster algorithms for
algebraic path properties in recursive state machines with constant treewidth.
ACM SIGPLAN Notices. 2015;50(1):97-109. doi:10.1145/2676726.2676979
apa: 'Chatterjee, K., Ibsen-Jensen, R., Pavlogiannis, A., & Goyal, P. (2015).
Faster algorithms for algebraic path properties in recursive state machines with
constant treewidth. ACM SIGPLAN Notices. Mumbai, India: ACM. https://doi.org/10.1145/2676726.2676979'
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, Andreas Pavlogiannis, and
Prateesh Goyal. “Faster Algorithms for Algebraic Path Properties in Recursive
State Machines with Constant Treewidth.” ACM SIGPLAN Notices. ACM, 2015.
https://doi.org/10.1145/2676726.2676979.
ieee: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, and P. Goyal, “Faster algorithms
for algebraic path properties in recursive state machines with constant treewidth,”
ACM SIGPLAN Notices, vol. 50, no. 1. ACM, pp. 97–109, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A, Goyal P. 2015. Faster algorithms
for algebraic path properties in recursive state machines with constant treewidth.
ACM SIGPLAN Notices. 50(1), 97–109.
mla: Chatterjee, Krishnendu, et al. “Faster Algorithms for Algebraic Path Properties
in Recursive State Machines with Constant Treewidth.” ACM SIGPLAN Notices,
vol. 50, no. 1, ACM, 2015, pp. 97–109, doi:10.1145/2676726.2676979.
short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, P. Goyal, ACM SIGPLAN Notices
50 (2015) 97–109.
conference:
end_date: 2015-01-17
location: Mumbai, India
name: 'SIGPLAN: Symposium on Principles of Programming Languages'
start_date: 2015-01-15
date_created: 2018-12-11T11:52:58Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-09-07T12:01:58Z
day: '01'
department:
- _id: KrCh
doi: 10.1145/2676726.2676979
ec_funded: 1
external_id:
arxiv:
- '1410.7724'
intvolume: ' 50'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1410.7724
month: '01'
oa: 1
oa_version: Preprint
page: 97 - 109
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: ACM SIGPLAN Notices
publication_status: published
publisher: ACM
publist_id: '5565'
quality_controlled: '1'
related_material:
record:
- id: '821'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Faster algorithms for algebraic path properties in recursive state machines
with constant treewidth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2015'
...
---
_id: '1604'
abstract:
- lang: eng
text: We consider the quantitative analysis problem for interprocedural control-flow
graphs (ICFGs). The input consists of an ICFG, a positive weight function that
assigns every transition a positive integer-valued number, and a labelling of
the transitions (events) as good, bad, and neutral events. The weight function
assigns to each transition a numerical value that represents ameasure of how good
or bad an event is. The quantitative analysis problem asks whether there is a
run of the ICFG where the ratio of the sum of the numerical weights of good events
versus the sum of weights of bad events in the long-run is at least a given threshold
(or equivalently, to compute the maximal ratio among all valid paths in the ICFG).
The quantitative analysis problem for ICFGs can be solved in polynomial time,
and we present an efficient and practical algorithm for the problem. We show that
several problems relevant for static program analysis, such as estimating the
worst-case execution time of a program or the average energy consumption of a
mobile application, can be modeled in our framework. We have implemented our algorithm
as a tool in the Java Soot framework. We demonstrate the effectiveness of our
approach with two case studies. First, we show that our framework provides a sound
approach (no false positives) for the analysis of inefficiently-used containers.
Second, we show that our approach can also be used for static profiling of programs
which reasons about methods that are frequently invoked. Our experimental results
show that our tool scales to relatively large benchmarks, and discovers relevant
and useful information that can be used to optimize performance of the programs.
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Yaron
full_name: Velner, Yaron
last_name: Velner
citation:
ama: Chatterjee K, Pavlogiannis A, Velner Y. Quantitative interprocedural analysis.
Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT . 2015;50(1):539-551.
doi:10.1145/2676726.2676968
apa: 'Chatterjee, K., Pavlogiannis, A., & Velner, Y. (2015). Quantitative interprocedural
analysis. Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT . Mumbai, India:
ACM. https://doi.org/10.1145/2676726.2676968'
chicago: Chatterjee, Krishnendu, Andreas Pavlogiannis, and Yaron Velner. “Quantitative
Interprocedural Analysis.” Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT
. ACM, 2015. https://doi.org/10.1145/2676726.2676968.
ieee: K. Chatterjee, A. Pavlogiannis, and Y. Velner, “Quantitative interprocedural
analysis,” Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT , vol. 50,
no. 1. ACM, pp. 539–551, 2015.
ista: Chatterjee K, Pavlogiannis A, Velner Y. 2015. Quantitative interprocedural
analysis. Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT . 50(1), 539–551.
mla: Chatterjee, Krishnendu, et al. “Quantitative Interprocedural Analysis.” Proceedings
of the 42nd Annual ACM SIGPLAN-SIGACT , vol. 50, no. 1, ACM, 2015, pp. 539–51,
doi:10.1145/2676726.2676968.
short: K. Chatterjee, A. Pavlogiannis, Y. Velner, Proceedings of the 42nd Annual
ACM SIGPLAN-SIGACT 50 (2015) 539–551.
conference:
end_date: 2015-01-17
location: Mumbai, India
name: 'SIGPLAN: Symposium on Principles of Programming Languages'
start_date: 2015-01-15
date_created: 2018-12-11T11:52:59Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-09-07T12:01:59Z
day: '01'
department:
- _id: KrCh
doi: 10.1145/2676726.2676968
ec_funded: 1
intvolume: ' 50'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 539 - 551
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: 'Proceedings of the 42nd Annual ACM SIGPLAN-SIGACT '
publication_identifier:
isbn:
- 978-1-4503-3300-9
publication_status: published
publisher: ACM
publist_id: '5563'
pubrep_id: '523'
quality_controlled: '1'
related_material:
record:
- id: '5445'
relation: earlier_version
status: public
- id: '821'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Quantitative interprocedural analysis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2015'
...
---
_id: '1607'
abstract:
- lang: eng
text: We consider the core algorithmic problems related to verification of systems
with respect to three classical quantitative properties, namely, the mean-payoff
property, the ratio property, and the minimum initial credit for energy property.
The algorithmic problem given a graph and a quantitative property asks to compute
the optimal value (the infimum value over all traces) from every node of the graph.
We consider graphs with constant treewidth, and it is well-known that the control-flow
graphs of most programs have constant treewidth. Let n denote the number of nodes
of a graph, m the number of edges (for constant treewidth graphs m=O(n)) and W
the largest absolute value of the weights. Our main theoretical results are as
follows. First, for constant treewidth graphs we present an algorithm that approximates
the mean-payoff value within a multiplicative factor of ϵ in time O(n⋅log(n/ϵ))
and linear space, as compared to the classical algorithms that require quadratic
time. Second, for the ratio property we present an algorithm that for constant
treewidth graphs works in time O(n⋅log(|a⋅b|))=O(n⋅log(n⋅W)), when the output
is ab, as compared to the previously best known algorithm with running time O(n2⋅log(n⋅W)).
Third, for the minimum initial credit problem we show that (i) for general graphs
the problem can be solved in O(n2⋅m) time and the associated decision problem
can be solved in O(n⋅m) time, improving the previous known O(n3⋅m⋅log(n⋅W)) and
O(n2⋅m) bounds, respectively; and (ii) for constant treewidth graphs we present
an algorithm that requires O(n⋅logn) time, improving the previous known O(n4⋅log(n⋅W))
bound. We have implemented some of our algorithms and show that they present a
significant speedup on standard benchmarks.
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
Grant No P23499- N23, FWF NFN Grant No S11407-N23 (RiSE/SHiNE), ERC Start grant
(279307: Graph Games), and Microsoft faculty fellows award.'
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Faster algorithms for quantitative
verification in constant treewidth graphs. In: Vol 9206. Springer; 2015:140-157.
doi:10.1007/978-3-319-21690-4_9'
apa: 'Chatterjee, K., Ibsen-Jensen, R., & Pavlogiannis, A. (2015). Faster algorithms
for quantitative verification in constant treewidth graphs (Vol. 9206, pp. 140–157).
Presented at the CAV: Computer Aided Verification, San Francisco, CA, USA: Springer.
https://doi.org/10.1007/978-3-319-21690-4_9'
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis.
“Faster Algorithms for Quantitative Verification in Constant Treewidth Graphs,”
9206:140–57. Springer, 2015. https://doi.org/10.1007/978-3-319-21690-4_9.
ieee: 'K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, “Faster algorithms for
quantitative verification in constant treewidth graphs,” presented at the CAV:
Computer Aided Verification, San Francisco, CA, USA, 2015, vol. 9206, pp. 140–157.'
ista: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2015. Faster algorithms for
quantitative verification in constant treewidth graphs. CAV: Computer Aided Verification,
LNCS, vol. 9206, 140–157.'
mla: Chatterjee, Krishnendu, et al. Faster Algorithms for Quantitative Verification
in Constant Treewidth Graphs. Vol. 9206, Springer, 2015, pp. 140–57, doi:10.1007/978-3-319-21690-4_9.
short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, in:, Springer, 2015, pp.
140–157.
conference:
end_date: 2015-07-24
location: San Francisco, CA, USA
name: 'CAV: Computer Aided Verification'
start_date: 2015-07-18
date_created: 2018-12-11T11:52:59Z
date_published: 2015-07-16T00:00:00Z
date_updated: 2023-09-07T12:01:59Z
day: '16'
department:
- _id: KrCh
doi: 10.1007/978-3-319-21690-4_9
ec_funded: 1
intvolume: ' 9206'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1504.07384
month: '07'
oa: 1
oa_version: Preprint
page: 140 - 157
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication_status: published
publisher: Springer
publist_id: '5560'
quality_controlled: '1'
related_material:
record:
- id: '5430'
relation: earlier_version
status: public
- id: '5437'
relation: earlier_version
status: public
- id: '821'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Faster algorithms for quantitative verification in constant treewidth graphs
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9206
year: '2015'
...
---
_id: '1714'
abstract:
- lang: eng
text: 'We present a flexible framework for the automated competitive analysis of
on-line scheduling algorithms for firm-deadline real-time tasks based on multi-objective
graphs: Given a task set and an on-line scheduling algorithm specified as a labeled
transition system, along with some optional safety, liveness, and/or limit-average
constraints for the adversary, we automatically compute the competitive ratio
of the algorithm w.r.t. A clairvoyant scheduler. We demonstrate the flexibility
and power of our approach by comparing the competitive ratio of several on-line
algorithms, including Dover, that have been proposed in the past, for various
task sets. Our experimental results reveal that none of these algorithms is universally
optimal, in the sense that there are task sets where other schedulers provide
better performance. Our framework is hence a very useful design tool for selecting
optimal algorithms for a given application.'
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Alexander
full_name: Kößler, Alexander
last_name: Kößler
- first_name: Ulrich
full_name: Schmid, Ulrich
last_name: Schmid
citation:
ama: 'Chatterjee K, Pavlogiannis A, Kößler A, Schmid U. A framework for automated
competitive analysis of on-line scheduling of firm-deadline tasks. In: Real-Time
Systems Symposium. Vol 2015. IEEE; 2015:118-127. doi:10.1109/RTSS.2014.9'
apa: 'Chatterjee, K., Pavlogiannis, A., Kößler, A., & Schmid, U. (2015). A framework
for automated competitive analysis of on-line scheduling of firm-deadline tasks.
In Real-Time Systems Symposium (Vol. 2015, pp. 118–127). Rome, Italy: IEEE.
https://doi.org/10.1109/RTSS.2014.9'
chicago: Chatterjee, Krishnendu, Andreas Pavlogiannis, Alexander Kößler, and Ulrich
Schmid. “A Framework for Automated Competitive Analysis of On-Line Scheduling
of Firm-Deadline Tasks.” In Real-Time Systems Symposium, 2015:118–27. IEEE,
2015. https://doi.org/10.1109/RTSS.2014.9.
ieee: K. Chatterjee, A. Pavlogiannis, A. Kößler, and U. Schmid, “A framework for
automated competitive analysis of on-line scheduling of firm-deadline tasks,”
in Real-Time Systems Symposium, Rome, Italy, 2015, vol. 2015, no. January,
pp. 118–127.
ista: 'Chatterjee K, Pavlogiannis A, Kößler A, Schmid U. 2015. A framework for automated
competitive analysis of on-line scheduling of firm-deadline tasks. Real-Time Systems
Symposium. RTSS: Real-Time Systems Symposium vol. 2015, 118–127.'
mla: Chatterjee, Krishnendu, et al. “A Framework for Automated Competitive Analysis
of On-Line Scheduling of Firm-Deadline Tasks.” Real-Time Systems Symposium,
vol. 2015, no. January, IEEE, 2015, pp. 118–27, doi:10.1109/RTSS.2014.9.
short: K. Chatterjee, A. Pavlogiannis, A. Kößler, U. Schmid, in:, Real-Time Systems
Symposium, IEEE, 2015, pp. 118–127.
conference:
end_date: 2014-12-05
location: Rome, Italy
name: 'RTSS: Real-Time Systems Symposium'
start_date: 2014-12-02
date_created: 2018-12-11T11:53:37Z
date_published: 2015-01-15T00:00:00Z
date_updated: 2023-09-07T12:01:59Z
day: '15'
department:
- _id: KrCh
doi: 10.1109/RTSS.2014.9
intvolume: ' 2015'
issue: January
language:
- iso: eng
month: '01'
oa_version: None
page: 118 - 127
publication: Real-Time Systems Symposium
publication_status: published
publisher: IEEE
publist_id: '5417'
quality_controlled: '1'
related_material:
record:
- id: '5423'
relation: earlier_version
status: public
- id: '821'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: A framework for automated competitive analysis of on-line scheduling of firm-deadline
tasks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2015
year: '2015'
...
---
_id: '1633'
abstract:
- lang: eng
text: "We present a method for simulating brittle fracture under the assumptions
of quasi-static linear elastic fracture mechanics (LEFM). Using the boundary element
method (BEM) and Lagrangian crack-fronts, we produce highly detailed fracture
surfaces. The computational cost of the BEM is alleviated by using a low-resolution
mesh and interpolating the resulting stress intensity factors when propagating
the high-resolution crack-front.\r\n\r\nOur system produces physics-based fracture
surfaces with high spatial and temporal resolution, taking spatial variation of
material toughness and/or strength into account. It also allows for crack initiation
to be handled separately from crack propagation, which is not only more reasonable
from a physics perspective, but can also be used to control the simulation.\r\n\r\nSeparating
the resolution of the crack-front from the resolution of the computational mesh
increases the efficiency and therefore the amount of visual detail on the resulting
fracture surfaces. The BEM also allows us to re-use previously computed blocks
of the system matrix."
article_number: '151'
author:
- first_name: David
full_name: Hahn, David
id: 357A6A66-F248-11E8-B48F-1D18A9856A87
last_name: Hahn
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: 'Hahn D, Wojtan C. High-resolution brittle fracture simulation with boundary
elements. In: Vol 34. ACM; 2015. doi:10.1145/2766896'
apa: 'Hahn, D., & Wojtan, C. (2015). High-resolution brittle fracture simulation
with boundary elements (Vol. 34). Presented at the SIGGRAPH: Special Interest
Group on Computer Graphics and Interactive Techniques, Los Angeles, CA, United
States: ACM. https://doi.org/10.1145/2766896'
chicago: Hahn, David, and Chris Wojtan. “High-Resolution Brittle Fracture Simulation
with Boundary Elements,” Vol. 34. ACM, 2015. https://doi.org/10.1145/2766896.
ieee: 'D. Hahn and C. Wojtan, “High-resolution brittle fracture simulation with
boundary elements,” presented at the SIGGRAPH: Special Interest Group on Computer
Graphics and Interactive Techniques, Los Angeles, CA, United States, 2015, vol.
34, no. 4.'
ista: 'Hahn D, Wojtan C. 2015. High-resolution brittle fracture simulation with
boundary elements. SIGGRAPH: Special Interest Group on Computer Graphics and Interactive
Techniques vol. 34, 151.'
mla: Hahn, David, and Chris Wojtan. High-Resolution Brittle Fracture Simulation
with Boundary Elements. Vol. 34, no. 4, 151, ACM, 2015, doi:10.1145/2766896.
short: D. Hahn, C. Wojtan, in:, ACM, 2015.
conference:
end_date: 2015-08-13
location: Los Angeles, CA, United States
name: 'SIGGRAPH: Special Interest Group on Computer Graphics and Interactive Techniques'
start_date: 2015-08-09
date_created: 2018-12-11T11:53:09Z
date_published: 2015-07-27T00:00:00Z
date_updated: 2023-09-07T12:02:56Z
day: '27'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/2766896
ec_funded: 1
file:
- access_level: open_access
checksum: 955aee971983f6b6152bcc1c9b4a7c20
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:13Z
date_updated: 2020-07-14T12:45:07Z
file_id: '5131'
file_name: IST-2016-609-v1+1_FractureBEM.pdf
file_size: 20154270
relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: ' 34'
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: Efficient Simulation of Natural Phenomena at Extremely Large Scales
publication_status: published
publisher: ACM
publist_id: '5522'
pubrep_id: '609'
quality_controlled: '1'
related_material:
record:
- id: '839'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: High-resolution brittle fracture simulation with boundary elements
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2015'
...
---
_id: '1537'
abstract:
- lang: eng
text: 3D amoeboid cell migration is central to many developmental and disease-related
processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid
cell migration mode in early zebrafish embryos, termed stable-bleb migration.
Stable-bleb cells display an invariant polarized balloon-like shape with exceptional
migration speed and persistence. Progenitor cells can be reversibly transformed
into stable-bleb cells irrespective of their primary fate and motile characteristics
by increasing myosin II activity through biochemical or mechanical stimuli. Using
a combination of theory and experiments, we show that, in stable-bleb cells, cortical
contractility fluctuations trigger a stochastic switch into amoeboid motility,
and a positive feedback between cortical flows and gradients in contractility
maintains stable-bleb cell polarization. We further show that rearward cortical
flows drive stable-bleb cell migration in various adhesive and non-adhesive environments,
unraveling a highly versatile amoeboid migration phenotype.
acknowledged_ssus:
- _id: SSU
acknowledgement: 'We would like to thank R. Hausschild and E. Papusheva for technical
assistance and the service facilities at the IST Austria for continuous support.
The caRhoA plasmid was a kind gift of T. Kudoh and A. Takesono. We thank M. Piel
and E. Paluch for exchanging unpublished data. '
author:
- first_name: Verena
full_name: Ruprecht, Verena
id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
last_name: Ruprecht
orcid: 0000-0003-4088-8633
- first_name: Stefan
full_name: Wieser, Stefan
id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
last_name: Wieser
orcid: 0000-0002-2670-2217
- first_name: Andrew
full_name: Callan Jones, Andrew
last_name: Callan Jones
- first_name: Michael
full_name: Smutny, Michael
id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
last_name: Smutny
orcid: 0000-0002-5920-9090
- first_name: Hitoshi
full_name: Morita, Hitoshi
id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
last_name: Morita
- first_name: Keisuke
full_name: Sako, Keisuke
id: 3BED66BE-F248-11E8-B48F-1D18A9856A87
last_name: Sako
orcid: 0000-0002-6453-8075
- first_name: Vanessa
full_name: Barone, Vanessa
id: 419EECCC-F248-11E8-B48F-1D18A9856A87
last_name: Barone
orcid: 0000-0003-2676-3367
- first_name: Monika
full_name: Ritsch Marte, Monika
last_name: Ritsch Marte
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Raphaël
full_name: Voituriez, Raphaël
last_name: Voituriez
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Ruprecht V, Wieser S, Callan Jones A, et al. Cortical contractility triggers
a stochastic switch to fast amoeboid cell motility. Cell. 2015;160(4):673-685.
doi:10.1016/j.cell.2015.01.008
apa: Ruprecht, V., Wieser, S., Callan Jones, A., Smutny, M., Morita, H., Sako, K.,
… Heisenberg, C.-P. J. (2015). Cortical contractility triggers a stochastic switch
to fast amoeboid cell motility. Cell. Cell Press. https://doi.org/10.1016/j.cell.2015.01.008
chicago: Ruprecht, Verena, Stefan Wieser, Andrew Callan Jones, Michael Smutny, Hitoshi
Morita, Keisuke Sako, Vanessa Barone, et al. “Cortical Contractility Triggers
a Stochastic Switch to Fast Amoeboid Cell Motility.” Cell. Cell Press,
2015. https://doi.org/10.1016/j.cell.2015.01.008.
ieee: V. Ruprecht et al., “Cortical contractility triggers a stochastic switch
to fast amoeboid cell motility,” Cell, vol. 160, no. 4. Cell Press, pp.
673–685, 2015.
ista: Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, Barone V,
Ritsch Marte M, Sixt MK, Voituriez R, Heisenberg C-PJ. 2015. Cortical contractility
triggers a stochastic switch to fast amoeboid cell motility. Cell. 160(4), 673–685.
mla: Ruprecht, Verena, et al. “Cortical Contractility Triggers a Stochastic Switch
to Fast Amoeboid Cell Motility.” Cell, vol. 160, no. 4, Cell Press, 2015,
pp. 673–85, doi:10.1016/j.cell.2015.01.008.
short: V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V.
Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160
(2015) 673–685.
date_created: 2018-12-11T11:52:35Z
date_published: 2015-02-12T00:00:00Z
date_updated: 2023-09-07T12:05:08Z
day: '12'
ddc:
- '570'
department:
- _id: CaHe
- _id: MiSi
doi: 10.1016/j.cell.2015.01.008
file:
- access_level: open_access
checksum: 228d3edf40627d897b3875088a0ac51f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:21Z
date_updated: 2020-07-14T12:45:01Z
file_id: '5003'
file_name: IST-2016-484-v1+1_1-s2.0-S0092867415000094-main.pdf
file_size: 4362653
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: ' 160'
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 673 - 685
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: T 560-B17
name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 2527D5CC-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 812-B12
name: Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5634'
pubrep_id: '484'
quality_controlled: '1'
related_material:
record:
- id: '961'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Cortical contractility triggers a stochastic switch to fast amoeboid cell motility
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2015'
...
---
_id: '1591'
abstract:
- lang: eng
text: Auxin participates in a multitude of developmental processes, as well as responses
to environmental cues. Compared with other plant hormones, auxin exhibits a unique
property, as it undergoes directional, cell-to-cell transport facilitated by plasma
membrane-localized transport proteins. Among them, a prominent role has been ascribed
to the PIN family of auxin efflux facilitators. PIN proteins direct polar auxin
transport on account of their asymmetric subcellular localizations. In this review,
we provide an overview of the multiple developmental roles of PIN proteins, including
the atypical endoplasmic reticulum-localized members of the family, and look at
the family from an evolutionary perspective. Next, we cover the cell biological
and molecular aspects of PIN function, in particular the establishment of their
polar subcellular localization. Hormonal and environmental inputs into the regulation
of PIN action are summarized as well.
author:
- first_name: Maciek
full_name: Adamowski, Maciek
id: 45F536D2-F248-11E8-B48F-1D18A9856A87
last_name: Adamowski
orcid: 0000-0001-6463-5257
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: 'Adamowski M, Friml J. PIN-dependent auxin transport: Action, regulation, and
evolution. Plant Cell. 2015;27(1):20-32. doi:10.1105/tpc.114.134874'
apa: 'Adamowski, M., & Friml, J. (2015). PIN-dependent auxin transport: Action,
regulation, and evolution. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.114.134874'
chicago: 'Adamowski, Maciek, and Jiří Friml. “PIN-Dependent Auxin Transport: Action,
Regulation, and Evolution.” Plant Cell. American Society of Plant Biologists,
2015. https://doi.org/10.1105/tpc.114.134874.'
ieee: 'M. Adamowski and J. Friml, “PIN-dependent auxin transport: Action, regulation,
and evolution,” Plant Cell, vol. 27, no. 1. American Society of Plant Biologists,
pp. 20–32, 2015.'
ista: 'Adamowski M, Friml J. 2015. PIN-dependent auxin transport: Action, regulation,
and evolution. Plant Cell. 27(1), 20–32.'
mla: 'Adamowski, Maciek, and Jiří Friml. “PIN-Dependent Auxin Transport: Action,
Regulation, and Evolution.” Plant Cell, vol. 27, no. 1, American Society
of Plant Biologists, 2015, pp. 20–32, doi:10.1105/tpc.114.134874.'
short: M. Adamowski, J. Friml, Plant Cell 27 (2015) 20–32.
date_created: 2018-12-11T11:52:54Z
date_published: 2015-01-20T00:00:00Z
date_updated: 2023-09-07T12:06:09Z
day: '20'
department:
- _id: JiFr
doi: 10.1105/tpc.114.134874
external_id:
pmid:
- '25604445'
intvolume: ' 27'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330589/
month: '01'
oa: 1
oa_version: Submitted Version
page: 20 - 32
pmid: 1
publication: Plant Cell
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '5580'
quality_controlled: '1'
related_material:
record:
- id: '938'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: 'PIN-dependent auxin transport: Action, regulation, and evolution'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2015'
...
---
_id: '1677'
abstract:
- lang: eng
text: We consider real symmetric and complex Hermitian random matrices with the
additional symmetry hxy = hN-y,N-x. The matrix elements are independent (up to
the fourfold symmetry) and not necessarily identically distributed. This ensemble
naturally arises as the Fourier transform of a Gaussian orthogonal ensemble. Italso
occurs as the flip matrix model - an approximation of the two-dimensional Anderson
model at small disorder. We show that the density of states converges to the Wigner
semicircle law despite the new symmetry type. We also prove the local version
of the semicircle law on the optimal scale.
article_number: '103301'
author:
- first_name: Johannes
full_name: Alt, Johannes
id: 36D3D8B6-F248-11E8-B48F-1D18A9856A87
last_name: Alt
citation:
ama: Alt J. The local semicircle law for random matrices with a fourfold symmetry.
Journal of Mathematical Physics. 2015;56(10). doi:10.1063/1.4932606
apa: Alt, J. (2015). The local semicircle law for random matrices with a fourfold
symmetry. Journal of Mathematical Physics. American Institute of Physics.
https://doi.org/10.1063/1.4932606
chicago: Alt, Johannes. “The Local Semicircle Law for Random Matrices with a Fourfold
Symmetry.” Journal of Mathematical Physics. American Institute of Physics,
2015. https://doi.org/10.1063/1.4932606.
ieee: J. Alt, “The local semicircle law for random matrices with a fourfold symmetry,”
Journal of Mathematical Physics, vol. 56, no. 10. American Institute of
Physics, 2015.
ista: Alt J. 2015. The local semicircle law for random matrices with a fourfold
symmetry. Journal of Mathematical Physics. 56(10), 103301.
mla: Alt, Johannes. “The Local Semicircle Law for Random Matrices with a Fourfold
Symmetry.” Journal of Mathematical Physics, vol. 56, no. 10, 103301, American
Institute of Physics, 2015, doi:10.1063/1.4932606.
short: J. Alt, Journal of Mathematical Physics 56 (2015).
date_created: 2018-12-11T11:53:25Z
date_published: 2015-10-09T00:00:00Z
date_updated: 2023-09-07T12:38:08Z
day: '09'
department:
- _id: LaEr
doi: 10.1063/1.4932606
ec_funded: 1
intvolume: ' 56'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1506.04683
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
publication: Journal of Mathematical Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '5472'
quality_controlled: '1'
related_material:
record:
- id: '149'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: The local semicircle law for random matrices with a fourfold symmetry
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 56
year: '2015'
...
---
_id: '1678'
abstract:
- lang: eng
text: High-throughput live-cell screens are intricate elements of systems biology
studies and drug discovery pipelines. Here, we demonstrate an optogenetics-assisted
method that avoids the need for chemical activators and reporters, reduces the
number of operational steps and increases information content in a cell-based
small-molecule screen against human protein kinases, including an orphan receptor
tyrosine kinase. This blueprint for all-optical screening can be adapted to many
drug targets and cellular processes.
acknowledgement: 'This work was supported by grants from the European Union Seventh
Framework Programme (CIG-303564 to H.J. and ERC-StG-311166 to S.M.B.N.), the Human
Frontier Science Program (RGY0084_2012 to H.J.) and the Herzfelder Foundation (to
M.G.). A.I.-P. was supported by a Ramon Areces fellowship, and E.R. by the graduate
program MolecularDrugTargets (Austrian Science Fund (FWF): W 1232) and a FemTech
fellowship (3580812 Austrian Research Promotion Agency).'
author:
- first_name: Álvaro
full_name: Inglés Prieto, Álvaro
id: 2A9DB292-F248-11E8-B48F-1D18A9856A87
last_name: Inglés Prieto
orcid: 0000-0002-5409-8571
- first_name: Eva
full_name: Gschaider-Reichhart, Eva
id: 3FEE232A-F248-11E8-B48F-1D18A9856A87
last_name: Gschaider-Reichhart
orcid: 0000-0002-7218-7738
- first_name: Markus
full_name: Muellner, Markus
last_name: Muellner
- first_name: Matthias
full_name: Nowak, Matthias
id: 30845DAA-F248-11E8-B48F-1D18A9856A87
last_name: Nowak
- first_name: Sebastian
full_name: Nijman, Sebastian
last_name: Nijman
- first_name: Michael
full_name: Grusch, Michael
last_name: Grusch
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, et al. Light-assisted small-molecule
screening against protein kinases. Nature Chemical Biology. 2015;11(12):952-954.
doi:10.1038/nchembio.1933
apa: Inglés Prieto, Á., Gschaider-Reichhart, E., Muellner, M., Nowak, M., Nijman,
S., Grusch, M., & Janovjak, H. L. (2015). Light-assisted small-molecule screening
against protein kinases. Nature Chemical Biology. Nature Publishing Group.
https://doi.org/10.1038/nchembio.1933
chicago: Inglés Prieto, Álvaro, Eva Gschaider-Reichhart, Markus Muellner, Matthias
Nowak, Sebastian Nijman, Michael Grusch, and Harald L Janovjak. “Light-Assisted
Small-Molecule Screening against Protein Kinases.” Nature Chemical Biology.
Nature Publishing Group, 2015. https://doi.org/10.1038/nchembio.1933.
ieee: Á. Inglés Prieto et al., “Light-assisted small-molecule screening against
protein kinases,” Nature Chemical Biology, vol. 11, no. 12. Nature Publishing
Group, pp. 952–954, 2015.
ista: Inglés Prieto Á, Gschaider-Reichhart E, Muellner M, Nowak M, Nijman S, Grusch
M, Janovjak HL. 2015. Light-assisted small-molecule screening against protein
kinases. Nature Chemical Biology. 11(12), 952–954.
mla: Inglés Prieto, Álvaro, et al. “Light-Assisted Small-Molecule Screening against
Protein Kinases.” Nature Chemical Biology, vol. 11, no. 12, Nature Publishing
Group, 2015, pp. 952–54, doi:10.1038/nchembio.1933.
short: Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman,
M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.
date_created: 2018-12-11T11:53:25Z
date_published: 2015-10-12T00:00:00Z
date_updated: 2023-09-07T12:49:09Z
day: '12'
ddc:
- '571'
department:
- _id: HaJa
- _id: LifeSc
doi: 10.1038/nchembio.1933
ec_funded: 1
file:
- access_level: open_access
checksum: e9fb251dfcb7cd209b83f17867e61321
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:51Z
date_updated: 2020-07-14T12:45:12Z
file_id: '4842'
file_name: IST-2017-837-v1+1_ingles-prieto.pdf
file_size: 1308364
relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '12'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 952 - 954
project:
- _id: 25548C20-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303564'
name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 255BFFFA-B435-11E9-9278-68D0E5697425
grant_number: RGY0084/2012
name: In situ real-time imaging of neurotransmitter signaling using designer optical
sensors (HFSP Young Investigator)
- _id: 255A6082-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: Nature Chemical Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5471'
pubrep_id: '837'
quality_controlled: '1'
related_material:
record:
- id: '418'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Light-assisted small-molecule screening against protein kinases
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2015'
...
---
_id: '1576'
abstract:
- lang: eng
text: 'Gene expression is controlled primarily by interactions between transcription
factor proteins (TFs) and the regulatory DNA sequence, a process that can be captured
well by thermodynamic models of regulation. These models, however, neglect regulatory
crosstalk: the possibility that noncognate TFs could initiate transcription, with
potentially disastrous effects for the cell. Here, we estimate the importance
of crosstalk, suggest that its avoidance strongly constrains equilibrium models
of TF binding, and propose an alternative nonequilibrium scheme that implements
kinetic proofreading to suppress erroneous initiation. This proposal is consistent
with the observed covalent modifications of the transcriptional apparatus and
predicts increased noise in gene expression as a trade-off for improved specificity.
Using information theory, we quantify this trade-off to find when optimal proofreading
architectures are favored over their equilibrium counterparts. Such architectures
exhibit significant super-Poisson noise at low expression in steady state.'
article_number: '248101'
author:
- first_name: Sarah A
full_name: Cepeda Humerez, Sarah A
id: 3DEE19A4-F248-11E8-B48F-1D18A9856A87
last_name: Cepeda Humerez
- first_name: Georg
full_name: Rieckh, Georg
id: 34DA8BD6-F248-11E8-B48F-1D18A9856A87
last_name: Rieckh
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
citation:
ama: Cepeda Humerez SA, Rieckh G, Tkačik G. Stochastic proofreading mechanism alleviates
crosstalk in transcriptional regulation. Physical Review Letters. 2015;115(24).
doi:10.1103/PhysRevLett.115.248101
apa: Cepeda Humerez, S. A., Rieckh, G., & Tkačik, G. (2015). Stochastic proofreading
mechanism alleviates crosstalk in transcriptional regulation. Physical Review
Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.115.248101
chicago: Cepeda Humerez, Sarah A, Georg Rieckh, and Gašper Tkačik. “Stochastic Proofreading
Mechanism Alleviates Crosstalk in Transcriptional Regulation.” Physical Review
Letters. American Physical Society, 2015. https://doi.org/10.1103/PhysRevLett.115.248101.
ieee: S. A. Cepeda Humerez, G. Rieckh, and G. Tkačik, “Stochastic proofreading mechanism
alleviates crosstalk in transcriptional regulation,” Physical Review Letters,
vol. 115, no. 24. American Physical Society, 2015.
ista: Cepeda Humerez SA, Rieckh G, Tkačik G. 2015. Stochastic proofreading mechanism
alleviates crosstalk in transcriptional regulation. Physical Review Letters. 115(24),
248101.
mla: Cepeda Humerez, Sarah A., et al. “Stochastic Proofreading Mechanism Alleviates
Crosstalk in Transcriptional Regulation.” Physical Review Letters, vol.
115, no. 24, 248101, American Physical Society, 2015, doi:10.1103/PhysRevLett.115.248101.
short: S.A. Cepeda Humerez, G. Rieckh, G. Tkačik, Physical Review Letters 115 (2015).
date_created: 2018-12-11T11:52:49Z
date_published: 2015-12-08T00:00:00Z
date_updated: 2023-09-07T12:55:21Z
day: '08'
department:
- _id: GaTk
doi: 10.1103/PhysRevLett.115.248101
ec_funded: 1
intvolume: ' 115'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1504.05716
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5595'
quality_controlled: '1'
related_material:
record:
- id: '6473'
relation: part_of_dissertation
status: public
scopus_import: 1
status: public
title: Stochastic proofreading mechanism alleviates crosstalk in transcriptional regulation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2015'
...
---
_id: '8183'
abstract:
- lang: eng
text: "We study conditions under which a finite simplicial complex $K$ can be mapped
to $\\mathbb R^d$ without higher-multiplicity intersections. An almost $r$-embedding
is a map $f: K\\to \\mathbb R^d$ such that the images of any $r$\r\npairwise disjoint
simplices of $K$ do not have a common point. We show that if $r$ is not a prime
power and $d\\geq 2r+1$, then there is a counterexample to the topological Tverberg
conjecture, i.e., there is an almost $r$-embedding of\r\nthe $(d+1)(r-1)$-simplex
in $\\mathbb R^d$. This improves on previous constructions of counterexamples
(for $d\\geq 3r$) based on a series of papers by M. \\\"Ozaydin, M. Gromov, P.
Blagojevi\\'c, F. Frick, G. Ziegler, and the second and fourth present authors.
The counterexamples are obtained by proving the following algebraic criterion
in codimension 2: If $r\\ge3$ and if $K$ is a finite $2(r-1)$-complex then there
exists an almost $r$-embedding $K\\to \\mathbb R^{2r}$ if and only if there exists
a general position PL map $f:K\\to \\mathbb R^{2r}$ such that the algebraic intersection
number of the $f$-images of any $r$ pairwise disjoint simplices of $K$ is zero.
This result can be restated in terms of cohomological obstructions or equivariant
maps, and extends an analogous codimension 3 criterion by the second and fourth
authors. As another application we classify ornaments $f:S^3 \\sqcup S^3\\sqcup
S^3\\to \\mathbb R^5$ up to ornament\r\nconcordance. It follows from work of M.
Freedman, V. Krushkal and P. Teichner that the analogous criterion for $r=2$ is
false. We prove a lemma on singular higher-dimensional Borromean rings, yielding
an elementary proof of the counterexample."
acknowledgement: We would like to thank A. Klyachko, V. Krushkal, S. Melikhov, M.
Tancer, P. Teichner and anonymous referees for helpful discussions.
article_number: '1511.03501'
article_processing_charge: No
author:
- first_name: Sergey
full_name: Avvakumov, Sergey
id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
last_name: Avvakumov
- first_name: Isaac
full_name: Mabillard, Isaac
id: 32BF9DAA-F248-11E8-B48F-1D18A9856A87
last_name: Mabillard
- first_name: A.
full_name: Skopenkov, A.
last_name: Skopenkov
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: Avvakumov S, Mabillard I, Skopenkov A, Wagner U. Eliminating higher-multiplicity
intersections, III. Codimension 2. arXiv.
apa: Avvakumov, S., Mabillard, I., Skopenkov, A., & Wagner, U. (n.d.). Eliminating
higher-multiplicity intersections, III. Codimension 2. arXiv.
chicago: Avvakumov, Sergey, Isaac Mabillard, A. Skopenkov, and Uli Wagner. “Eliminating
Higher-Multiplicity Intersections, III. Codimension 2.” ArXiv, n.d.
ieee: S. Avvakumov, I. Mabillard, A. Skopenkov, and U. Wagner, “Eliminating higher-multiplicity
intersections, III. Codimension 2,” arXiv. .
ista: Avvakumov S, Mabillard I, Skopenkov A, Wagner U. Eliminating higher-multiplicity
intersections, III. Codimension 2. arXiv, 1511.03501.
mla: Avvakumov, Sergey, et al. “Eliminating Higher-Multiplicity Intersections, III.
Codimension 2.” ArXiv, 1511.03501.
short: S. Avvakumov, I. Mabillard, A. Skopenkov, U. Wagner, ArXiv (n.d.).
date_created: 2020-07-30T10:45:19Z
date_published: 2015-11-15T00:00:00Z
date_updated: 2023-09-07T13:12:17Z
day: '15'
department:
- _id: UlWa
external_id:
arxiv:
- '1511.03501'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1511.03501
month: '11'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '9308'
relation: later_version
status: public
- id: '10220'
relation: later_version
status: public
- id: '8156'
relation: dissertation_contains
status: public
status: public
title: Eliminating higher-multiplicity intersections, III. Codimension 2
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5441'
abstract:
- lang: eng
text: We study algorithmic questions for concurrent systems where the transitions
are labeled from a complete, closed semiring, and path properties are algebraic
with semiring operations. The algebraic path properties can model dataflow analysis
problems, the shortest path problem, and many other natural problems that arise
in program analysis. We consider that each component of the concurrent system
is a graph with constant treewidth, a property satisfied by the controlflow graphs
of most programs. We allow for multiple possible queries, which arise naturally
in demand driven dataflow analysis. The study of multiple queries allows us to
consider the tradeoff between the resource usage of the one-time preprocessing
and for each individual query. The traditional approach constructs the product
graph of all components and applies the best-known graph algorithm on the product.
In this approach, even the answer to a single query requires the transitive closure
(i.e., the results of all possible queries), which provides no room for tradeoff
between preprocessing and query time. Our main contributions are algorithms that
significantly improve the worst-case running time of the traditional approach,
and provide various tradeoffs depending on the number of queries. For example,
in a concurrent system of two components, the traditional approach requires hexic
time in the worst case for answering one query as well as computing the transitive
closure, whereas we show that with one-time preprocessing in almost cubic time,
each subsequent query can be answered in at most linear time, and even the transitive
closure can be computed in almost quartic time. Furthermore, we establish conditional
optimality results showing that the worst-case running time of our algorithms
cannot be improved without achieving major breakthroughs in graph algorithms (i.e.,
improving the worst-case bound for the shortest path problem in general graphs).
Preliminary experimental results show that our algorithms perform favorably on
several benchmarks.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Amir
full_name: Goharshady, Amir
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: Chatterjee K, Ibsen-Jensen R, Goharshady AK, Pavlogiannis A. Algorithms
for Algebraic Path Properties in Concurrent Systems of Constant Treewidth Components.
IST Austria; 2015. doi:10.15479/AT:IST-2015-340-v1-1
apa: Chatterjee, K., Ibsen-Jensen, R., Goharshady, A. K., & Pavlogiannis, A.
(2015). Algorithms for algebraic path properties in concurrent systems of constant
treewidth components. IST Austria. https://doi.org/10.15479/AT:IST-2015-340-v1-1
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, Amir Kafshdar Goharshady,
and Andreas Pavlogiannis. Algorithms for Algebraic Path Properties in Concurrent
Systems of Constant Treewidth Components. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-340-v1-1.
ieee: K. Chatterjee, R. Ibsen-Jensen, A. K. Goharshady, and A. Pavlogiannis, Algorithms
for algebraic path properties in concurrent systems of constant treewidth components.
IST Austria, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Goharshady AK, Pavlogiannis A. 2015. Algorithms
for algebraic path properties in concurrent systems of constant treewidth components,
IST Austria, 24p.
mla: Chatterjee, Krishnendu, et al. Algorithms for Algebraic Path Properties
in Concurrent Systems of Constant Treewidth Components. IST Austria, 2015,
doi:10.15479/AT:IST-2015-340-v1-1.
short: K. Chatterjee, R. Ibsen-Jensen, A.K. Goharshady, A. Pavlogiannis, Algorithms
for Algebraic Path Properties in Concurrent Systems of Constant Treewidth Components,
IST Austria, 2015.
date_created: 2018-12-12T11:39:21Z
date_published: 2015-07-11T00:00:00Z
date_updated: 2023-09-19T14:36:19Z
day: '11'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-340-v1-1
file:
- access_level: open_access
checksum: df383dc62c94d7b2ea639aba088a76c6
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:54:09Z
date_updated: 2020-07-14T12:46:56Z
file_id: '5531'
file_name: IST-2015-340-v1+1_main.pdf
file_size: 861396
relation: main_file
file_date_updated: 2020-07-14T12:46:56Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '24'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '340'
related_material:
record:
- id: '1437'
relation: later_version
status: public
- id: '5442'
relation: earlier_version
status: public
- id: '6009'
relation: later_version
status: public
status: public
title: Algorithms for algebraic path properties in concurrent systems of constant
treewidth components
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5442'
abstract:
- lang: eng
text: "We study algorithmic questions for concurrent systems where the transitions
are labeled from a complete, closed semiring, and path properties are algebraic
with semiring operations. The algebraic path properties can model dataflow analysis
problems, the shortest path problem, and many other natural properties that arise
in program analysis.\r\nWe consider that each component of the concurrent system
is a graph with constant treewidth, and it is known that the controlflow graphs
of most programs have constant treewidth. We allow for multiple possible queries,
which arise naturally in demand driven dataflow analysis problems (e.g., alias
analysis). The study of multiple queries allows us to consider the tradeoff between
the resource usage of the \\emph{one-time} preprocessing and for \\emph{each individual}
query. The traditional approaches construct the product graph of all components
and apply the best-known graph algorithm on the product. In the traditional approach,
even the answer to a single query requires the transitive closure computation
(i.e., the results of all possible queries), which provides no room for tradeoff
between preprocessing and query time.\r\n\r\nOur main contributions are algorithms
that significantly improve the worst-case running time of the traditional approach,
and provide various tradeoffs depending on the number of queries. For example,
in a concurrent system of two components, the traditional approach requires hexic
time in the worst case for answering one query as well as computing the transitive
closure, whereas we show that with one-time preprocessing in almost cubic time,
\r\neach subsequent query can be answered in at most linear time, and even the
transitive closure can be computed in almost quartic time. Furthermore, we establish
conditional optimality results that show that the worst-case running times of
our algorithms cannot be improved without achieving major breakthroughs in graph
algorithms (such as improving \r\nthe worst-case bounds for the shortest path
problem in general graphs whose current best-known bound has not been improved
in five decades). Finally, we provide a prototype implementation of our algorithms
which significantly outperforms the existing algorithmic methods on several benchmarks."
alternative_title:
- IST Austria Technical Report
author:
- first_name: '1'
full_name: Anonymous, 1
last_name: Anonymous
- first_name: '2'
full_name: Anonymous, 2
last_name: Anonymous
- first_name: '3'
full_name: Anonymous, 3
last_name: Anonymous
- first_name: '4'
full_name: Anonymous, 4
last_name: Anonymous
citation:
ama: Anonymous 1, Anonymous 2, Anonymous 3, Anonymous 4. Algorithms for Algebraic
Path Properties in Concurrent Systems of Constant Treewidth Components. IST
Austria; 2015.
apa: Anonymous, 1, Anonymous, 2, Anonymous, 3, & Anonymous, 4. (2015). Algorithms
for algebraic path properties in concurrent systems of constant treewidth components.
IST Austria.
chicago: Anonymous, 1, 2 Anonymous, 3 Anonymous, and 4 Anonymous. Algorithms
for Algebraic Path Properties in Concurrent Systems of Constant Treewidth Components.
IST Austria, 2015.
ieee: 1 Anonymous, 2 Anonymous, 3 Anonymous, and 4 Anonymous, Algorithms for
algebraic path properties in concurrent systems of constant treewidth components.
IST Austria, 2015.
ista: Anonymous 1, Anonymous 2, Anonymous 3, Anonymous 4. 2015. Algorithms for algebraic
path properties in concurrent systems of constant treewidth components, IST Austria,
22p.
mla: Anonymous, 1, et al. Algorithms for Algebraic Path Properties in Concurrent
Systems of Constant Treewidth Components. IST Austria, 2015.
short: 1 Anonymous, 2 Anonymous, 3 Anonymous, 4 Anonymous, Algorithms for Algebraic
Path Properties in Concurrent Systems of Constant Treewidth Components, IST Austria,
2015.
date_created: 2018-12-12T11:39:21Z
date_published: 2015-07-14T00:00:00Z
date_updated: 2023-09-19T14:36:19Z
day: '14'
ddc:
- '000'
file:
- access_level: open_access
checksum: 98fd936102f3e057fc321ef6d316001d
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:37Z
date_updated: 2020-07-14T12:46:57Z
file_id: '5498'
file_name: IST-2015-343-v2+1_main.pdf
file_size: 658747
relation: main_file
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checksum: b31d09b1241b59c75e1f42dadf09d258
content_type: text/plain
creator: dernst
date_created: 2019-04-16T12:36:08Z
date_updated: 2020-07-14T12:46:57Z
file_id: '6316'
file_name: IST-2015-343-v2+2_anonymous.txt
file_size: 139
relation: main_file
file_date_updated: 2020-07-14T12:46:57Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '22'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '344'
related_material:
record:
- id: '1437'
relation: later_version
status: public
- id: '5441'
relation: later_version
status: public
- id: '6009'
relation: later_version
status: public
scopus_import: 1
status: public
title: Algorithms for algebraic path properties in concurrent systems of constant
treewidth components
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1689'
abstract:
- lang: eng
text: We consider the problem of computing the set of initial states of a dynamical
system such that there exists a control strategy to ensure that the trajectories
satisfy a temporal logic specification with probability 1 (almost-surely). We
focus on discrete-time, stochastic linear dynamics and specifications given as
formulas of the Generalized Reactivity(1) fragment of Linear Temporal Logic over
linear predicates in the states of the system. We propose a solution based on
iterative abstraction-refinement, and turn-based 2-player probabilistic games.
While the theoretical guarantee of our algorithm after any finite number of iterations
is only a partial solution, we show that if our algorithm terminates, then the
result is the set of satisfying initial states. Moreover, for any (partial) solution
our algorithm synthesizes witness control strategies to ensure almost-sure satisfaction
of the temporal logic specification. We demonstrate our approach on an illustrative
case study.
author:
- first_name: Mária
full_name: Svoreňová, Mária
last_name: Svoreňová
- first_name: Jan
full_name: Kretinsky, Jan
id: 44CEF464-F248-11E8-B48F-1D18A9856A87
last_name: Kretinsky
orcid: 0000-0002-8122-2881
- first_name: Martin
full_name: Chmelik, Martin
id: 3624234E-F248-11E8-B48F-1D18A9856A87
last_name: Chmelik
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Ivana
full_name: Cěrná, Ivana
last_name: Cěrná
- first_name: Cǎlin
full_name: Belta, Cǎlin
last_name: Belta
citation:
ama: 'Svoreňová M, Kretinsky J, Chmelik M, Chatterjee K, Cěrná I, Belta C. Temporal
logic control for stochastic linear systems using abstraction refinement of probabilistic
games. In: Proceedings of the 18th International Conference on Hybrid Systems:
Computation and Control. ACM; 2015:259-268. doi:10.1145/2728606.2728608'
apa: 'Svoreňová, M., Kretinsky, J., Chmelik, M., Chatterjee, K., Cěrná, I., &
Belta, C. (2015). Temporal logic control for stochastic linear systems using abstraction
refinement of probabilistic games. In Proceedings of the 18th International
Conference on Hybrid Systems: Computation and Control (pp. 259–268). Seattle,
WA, United States: ACM. https://doi.org/10.1145/2728606.2728608'
chicago: 'Svoreňová, Mária, Jan Kretinsky, Martin Chmelik, Krishnendu Chatterjee,
Ivana Cěrná, and Cǎlin Belta. “Temporal Logic Control for Stochastic Linear Systems
Using Abstraction Refinement of Probabilistic Games.” In Proceedings of the
18th International Conference on Hybrid Systems: Computation and Control,
259–68. ACM, 2015. https://doi.org/10.1145/2728606.2728608.'
ieee: 'M. Svoreňová, J. Kretinsky, M. Chmelik, K. Chatterjee, I. Cěrná, and C. Belta,
“Temporal logic control for stochastic linear systems using abstraction refinement
of probabilistic games,” in Proceedings of the 18th International Conference
on Hybrid Systems: Computation and Control, Seattle, WA, United States, 2015,
pp. 259–268.'
ista: 'Svoreňová M, Kretinsky J, Chmelik M, Chatterjee K, Cěrná I, Belta C. 2015.
Temporal logic control for stochastic linear systems using abstraction refinement
of probabilistic games. Proceedings of the 18th International Conference on Hybrid
Systems: Computation and Control. HSCC: Hybrid Systems - Computation and Control,
259–268.'
mla: 'Svoreňová, Mária, et al. “Temporal Logic Control for Stochastic Linear Systems
Using Abstraction Refinement of Probabilistic Games.” Proceedings of the 18th
International Conference on Hybrid Systems: Computation and Control, ACM,
2015, pp. 259–68, doi:10.1145/2728606.2728608.'
short: 'M. Svoreňová, J. Kretinsky, M. Chmelik, K. Chatterjee, I. Cěrná, C. Belta,
in:, Proceedings of the 18th International Conference on Hybrid Systems: Computation
and Control, ACM, 2015, pp. 259–268.'
conference:
end_date: 2015-04-16
location: Seattle, WA, United States
name: 'HSCC: Hybrid Systems - Computation and Control'
start_date: 2015-04-14
date_created: 2018-12-11T11:53:29Z
date_published: 2015-04-14T00:00:00Z
date_updated: 2023-09-20T09:43:09Z
day: '14'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1145/2728606.2728608
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1410.5387
month: '04'
oa: 1
oa_version: Preprint
page: 259 - 268
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: 'Proceedings of the 18th International Conference on Hybrid Systems:
Computation and Control'
publication_status: published
publisher: ACM
publist_id: '5456'
related_material:
record:
- id: '1407'
relation: later_version
status: public
scopus_import: 1
status: public
title: Temporal logic control for stochastic linear systems using abstraction refinement
of probabilistic games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1729'
abstract:
- lang: eng
text: We present a computer-aided programming approach to concurrency. The approach
allows programmers to program assuming a friendly, non-preemptive scheduler, and
our synthesis procedure inserts synchronization to ensure that the final program
works even with a preemptive scheduler. The correctness specification is implicit,
inferred from the non-preemptive behavior. Let us consider sequences of calls
that the program makes to an external interface. The specification requires that
any such sequence produced under a preemptive scheduler should be included in
the set of such sequences produced under a non-preemptive scheduler. The solution
is based on a finitary abstraction, an algorithm for bounded language inclusion
modulo an independence relation, and rules for inserting synchronization. We apply
the approach to device-driver programming, where the driver threads call the software
interface of the device and the API provided by the operating system. Our experiments
demonstrate that our synthesis method is precise and efficient, and, since it
does not require explicit specifications, is more practical than the conventional
approach based on user-provided assertions.
alternative_title:
- LNCS
author:
- first_name: Pavol
full_name: Cerny, Pavol
id: 4DCBEFFE-F248-11E8-B48F-1D18A9856A87
last_name: Cerny
- first_name: Edmund
full_name: Clarke, Edmund
last_name: Clarke
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Arjun
full_name: Radhakrishna, Arjun
id: 3B51CAC4-F248-11E8-B48F-1D18A9856A87
last_name: Radhakrishna
- first_name: Leonid
full_name: Ryzhyk, Leonid
last_name: Ryzhyk
- first_name: Roopsha
full_name: Samanta, Roopsha
id: 3D2AAC08-F248-11E8-B48F-1D18A9856A87
last_name: Samanta
- first_name: Thorsten
full_name: Tarrach, Thorsten
id: 3D6E8F2C-F248-11E8-B48F-1D18A9856A87
last_name: Tarrach
orcid: 0000-0003-4409-8487
citation:
ama: Cerny P, Clarke E, Henzinger TA, et al. From non-preemptive to preemptive scheduling
using synchronization synthesis. 2015;9207:180-197. doi:10.1007/978-3-319-21668-3_11
apa: 'Cerny, P., Clarke, E., Henzinger, T. A., Radhakrishna, A., Ryzhyk, L., Samanta,
R., & Tarrach, T. (2015). From non-preemptive to preemptive scheduling using
synchronization synthesis. Presented at the CAV: Computer Aided Verification,
San Francisco, CA, United States: Springer. https://doi.org/10.1007/978-3-319-21668-3_11'
chicago: Cerny, Pavol, Edmund Clarke, Thomas A Henzinger, Arjun Radhakrishna, Leonid
Ryzhyk, Roopsha Samanta, and Thorsten Tarrach. “From Non-Preemptive to Preemptive
Scheduling Using Synchronization Synthesis.” Lecture Notes in Computer Science.
Springer, 2015. https://doi.org/10.1007/978-3-319-21668-3_11.
ieee: P. Cerny et al., “From non-preemptive to preemptive scheduling using
synchronization synthesis,” vol. 9207. Springer, pp. 180–197, 2015.
ista: Cerny P, Clarke E, Henzinger TA, Radhakrishna A, Ryzhyk L, Samanta R, Tarrach
T. 2015. From non-preemptive to preemptive scheduling using synchronization synthesis.
9207, 180–197.
mla: Cerny, Pavol, et al. From Non-Preemptive to Preemptive Scheduling Using
Synchronization Synthesis. Vol. 9207, Springer, 2015, pp. 180–97, doi:10.1007/978-3-319-21668-3_11.
short: P. Cerny, E. Clarke, T.A. Henzinger, A. Radhakrishna, L. Ryzhyk, R. Samanta,
T. Tarrach, 9207 (2015) 180–197.
conference:
end_date: 2015-07-24
location: San Francisco, CA, United States
name: 'CAV: Computer Aided Verification'
start_date: 2015-07-18
date_created: 2018-12-11T11:53:42Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2023-09-20T11:13:50Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-21668-3_11
ec_funded: 1
file:
- access_level: local
checksum: 6ff58ac220e2f20cb001ba35d4924495
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:53Z
date_updated: 2020-07-14T12:45:13Z
file_id: '4715'
file_name: IST-2015-336-v1+1_long_version.pdf
file_size: 481922
relation: main_file
file_date_updated: 2020-07-14T12:45:13Z
has_accepted_license: '1'
intvolume: ' 9207'
language:
- iso: eng
month: '07'
oa_version: Submitted Version
page: 180 - 197
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '5398'
pubrep_id: '336'
quality_controlled: '1'
related_material:
record:
- id: '1130'
relation: dissertation_contains
status: public
- id: '1338'
relation: later_version
status: public
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: From non-preemptive to preemptive scheduling using synchronization synthesis
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9207
year: '2015'
...
---
_id: '1835'
abstract:
- lang: eng
text: The behaviour of gene regulatory networks (GRNs) is typically analysed using
simulation-based statistical testing-like methods. In this paper, we demonstrate
that we can replace this approach by a formal verification-like method that gives
higher assurance and scalability. We focus on Wagner’s weighted GRN model with
varying weights, which is used in evolutionary biology. In the model, weight parameters
represent the gene interaction strength that may change due to genetic mutations.
For a property of interest, we synthesise the constraints over the parameter space
that represent the set of GRNs satisfying the property. We experimentally show
that our parameter synthesis procedure computes the mutational robustness of GRNs
–an important problem of interest in evolutionary biology– more efficiently than
the classical simulation method. We specify the property in linear temporal logics.
We employ symbolic bounded model checking and SMT solving to compute the space
of GRNs that satisfy the property, which amounts to synthesizing a set of linear
constraints on the weights.
acknowledgement: "SNSF Early Postdoc.Mobility Fellowship, the grant number P2EZP2
148797.\r\n"
alternative_title:
- LNCS
author:
- first_name: Mirco
full_name: Giacobbe, Mirco
id: 3444EA5E-F248-11E8-B48F-1D18A9856A87
last_name: Giacobbe
orcid: 0000-0001-8180-0904
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Ashutosh
full_name: Gupta, Ashutosh
id: 335E5684-F248-11E8-B48F-1D18A9856A87
last_name: Gupta
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Tatjana
full_name: Petrov, Tatjana
id: 3D5811FC-F248-11E8-B48F-1D18A9856A87
last_name: Petrov
orcid: 0000-0002-9041-0905
citation:
ama: Giacobbe M, Guet CC, Gupta A, Henzinger TA, Paixao T, Petrov T. Model checking
gene regulatory networks. 2015;9035:469-483. doi:10.1007/978-3-662-46681-0_47
apa: 'Giacobbe, M., Guet, C. C., Gupta, A., Henzinger, T. A., Paixao, T., &
Petrov, T. (2015). Model checking gene regulatory networks. Presented at the TACAS:
Tools and Algorithms for the Construction and Analysis of Systems, London, United
Kingdom: Springer. https://doi.org/10.1007/978-3-662-46681-0_47'
chicago: Giacobbe, Mirco, Calin C Guet, Ashutosh Gupta, Thomas A Henzinger, Tiago
Paixao, and Tatjana Petrov. “Model Checking Gene Regulatory Networks.” Lecture
Notes in Computer Science. Springer, 2015. https://doi.org/10.1007/978-3-662-46681-0_47.
ieee: M. Giacobbe, C. C. Guet, A. Gupta, T. A. Henzinger, T. Paixao, and T. Petrov,
“Model checking gene regulatory networks,” vol. 9035. Springer, pp. 469–483, 2015.
ista: Giacobbe M, Guet CC, Gupta A, Henzinger TA, Paixao T, Petrov T. 2015. Model
checking gene regulatory networks. 9035, 469–483.
mla: Giacobbe, Mirco, et al. Model Checking Gene Regulatory Networks. Vol.
9035, Springer, 2015, pp. 469–83, doi:10.1007/978-3-662-46681-0_47.
short: M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, 9035
(2015) 469–483.
conference:
end_date: 2015-04-18
location: London, United Kingdom
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2015-04-11
date_created: 2018-12-11T11:54:16Z
date_published: 2015-04-01T00:00:00Z
date_updated: 2023-09-20T11:06:03Z
day: '01'
department:
- _id: ToHe
- _id: CaGu
- _id: NiBa
doi: 10.1007/978-3-662-46681-0_47
ec_funded: 1
intvolume: ' 9035'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1410.7704
month: '04'
oa: 1
oa_version: Preprint
page: 469 - 483
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Springer
publist_id: '5267'
quality_controlled: '1'
related_material:
record:
- id: '1351'
relation: later_version
status: public
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: Model checking gene regulatory networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9035
year: '2015'
...
---
_id: '1509'
abstract:
- lang: eng
text: The Auxin Binding Protein1 (ABP1) has been identified based on its ability
to bind auxin with high affinity and studied for a long time as a prime candidate
for the extracellular auxin receptor responsible for mediating in particular the
fast non-transcriptional auxin responses. However, the contradiction between the
embryo-lethal phenotypes of the originally described Arabidopsis T-DNA insertional
knock-out alleles (abp1-1 and abp1-1s) and the wild type-like phenotypes of other
recently described loss-of-function alleles (abp1-c1 and abp1-TD1) questions the
biological importance of ABP1 and relevance of the previous genetic studies. Here
we show that there is no hidden copy of the ABP1 gene in the Arabidopsis genome
but the embryo-lethal phenotypes of abp1-1 and abp1-1s alleles are very similar
to the knock-out phenotypes of the neighboring gene, BELAYA SMERT (BSM). Furthermore,
the allelic complementation test between bsm and abp1 alleles shows that the embryo-lethality
in the abp1-1 and abp1-1s alleles is caused by the off-target disruption of the
BSM locus by the T-DNA insertions. This clarifies the controversy of different
phenotypes among published abp1 knock-out alleles and asks for reflections on
the developmental role of ABP1.
acknowledgement: "This work was supported by ERC Independent Research grant (ERC-2011-StG-20101109-PSDP
to JF). JM internship was supported by the grant “Action Austria – Slovakia”.\r\nData
associated with the article are available under the terms of the Creative Commons
Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication). \r\n\r\nData
availability: \r\nF1000Research: Dataset 1. Dataset 1, 10.5256/f1000research.7143.d104552\r\n\r\nF1000Research:
Dataset 2. Dataset 2, 10.5256/f1000research.7143.d104553\r\n\r\nF1000Research: Dataset
3. Dataset 3, 10.5256/f1000research.7143.d104554"
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author:
- first_name: Jaroslav
full_name: Michalko, Jaroslav
id: 483727CA-F248-11E8-B48F-1D18A9856A87
last_name: Michalko
- first_name: Marta
full_name: Dravecka, Marta
id: 4342E402-F248-11E8-B48F-1D18A9856A87
last_name: Dravecka
orcid: 0000-0002-2519-8004
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Michalko J, Lukacisinova M, Bollenbach MT, Friml J. Embryo-lethal phenotypes
in early abp1 mutants are due to disruption of the neighboring BSM gene. F1000
Research . 2015;4. doi:10.12688/f1000research.7143.1
apa: Michalko, J., Lukacisinova, M., Bollenbach, M. T., & Friml, J. (2015).
Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring
BSM gene. F1000 Research . F1000 Research. https://doi.org/10.12688/f1000research.7143.1
chicago: Michalko, Jaroslav, Marta Lukacisinova, Mark Tobias Bollenbach, and Jiří
Friml. “Embryo-Lethal Phenotypes in Early Abp1 Mutants Are Due to Disruption of
the Neighboring BSM Gene.” F1000 Research . F1000 Research, 2015. https://doi.org/10.12688/f1000research.7143.1.
ieee: J. Michalko, M. Lukacisinova, M. T. Bollenbach, and J. Friml, “Embryo-lethal
phenotypes in early abp1 mutants are due to disruption of the neighboring BSM
gene,” F1000 Research , vol. 4. F1000 Research, 2015.
ista: Michalko J, Lukacisinova M, Bollenbach MT, Friml J. 2015. Embryo-lethal phenotypes
in early abp1 mutants are due to disruption of the neighboring BSM gene. F1000
Research . 4.
mla: Michalko, Jaroslav, et al. “Embryo-Lethal Phenotypes in Early Abp1 Mutants
Are Due to Disruption of the Neighboring BSM Gene.” F1000 Research , vol.
4, F1000 Research, 2015, doi:10.12688/f1000research.7143.1.
short: J. Michalko, M. Lukacisinova, M.T. Bollenbach, J. Friml, F1000 Research 4
(2015).
date_created: 2018-12-11T11:52:26Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2023-10-10T14:10:24Z
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- _id: ToBo
doi: 10.12688/f1000research.7143.1
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project:
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grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: 'F1000 Research '
publication_status: published
publisher: F1000 Research
publist_id: '5668'
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title: Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the
neighboring BSM gene
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...