---
_id: '5436'
abstract:
- lang: eng
text: "Recently there has been a significant effort to handle quantitative properties
in formal verification and synthesis. While weighted automata over finite and
infinite words provide a natural and flexible framework to express quantitative
properties, perhaps surprisingly, some basic system properties such as average
response time cannot be expressed using weighted automata, nor in any other know
decidable formalism. In this work, we introduce nested weighted automata as a
natural extension of weighted automata which makes it possible to express important
quantitative properties such as average response time.\r\nIn nested weighted automata,
a master automaton spins off and collects results from weighted slave automata,
each of which computes a quantity along a finite portion of an infinite word.
Nested weighted automata can be viewed as the quantitative analogue of monitor
automata, which are used in run-time verification. We establish an almost complete
decidability picture for the basic decision problems about nested weighted automata,
and illustrate their applicability in several domains. In particular, nested weighted
automata can be used to decide average response time properties."
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
citation:
ama: Chatterjee K, Henzinger TA, Otop J. Nested Weighted Automata. IST Austria;
2015. doi:10.15479/AT:IST-2015-170-v2-2
apa: Chatterjee, K., Henzinger, T. A., & Otop, J. (2015). Nested weighted
automata. IST Austria. https://doi.org/10.15479/AT:IST-2015-170-v2-2
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Jan Otop. Nested Weighted
Automata. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-170-v2-2.
ieee: K. Chatterjee, T. A. Henzinger, and J. Otop, Nested weighted automata.
IST Austria, 2015.
ista: Chatterjee K, Henzinger TA, Otop J. 2015. Nested weighted automata, IST Austria,
29p.
mla: Chatterjee, Krishnendu, et al. Nested Weighted Automata. IST Austria,
2015, doi:10.15479/AT:IST-2015-170-v2-2.
short: K. Chatterjee, T.A. Henzinger, J. Otop, Nested Weighted Automata, IST Austria,
2015.
date_created: 2018-12-12T11:39:19Z
date_published: 2015-04-24T00:00:00Z
date_updated: 2023-02-23T12:25:21Z
day: '24'
ddc:
- '000'
department:
- _id: KrCh
- _id: ToHe
doi: 10.15479/AT:IST-2015-170-v2-2
file:
- access_level: open_access
checksum: 3c402f47d3669c28d04d1af405a08e3f
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:54:19Z
date_updated: 2020-07-14T12:46:54Z
file_id: '5541'
file_name: IST-2015-170-v2+2_report.pdf
file_size: 569991
relation: main_file
file_date_updated: 2020-07-14T12:46:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '29'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '331'
related_material:
record:
- id: '1656'
relation: later_version
status: public
- id: '467'
relation: later_version
status: public
- id: '5415'
relation: earlier_version
status: public
status: public
title: Nested weighted automata
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1659'
abstract:
- lang: eng
text: 'The target discounted-sum problem is the following: Given a rational discount
factor 0 < λ < 1 and three rational values a, b, and t, does there exist
a finite or an infinite sequence w ε(a, b)∗ or w ε(a, b)w, such that Σ|w| i=0
w(i)λi equals t? The problem turns out to relate to many fields of mathematics
and computer science, and its decidability question is surprisingly hard to solve.
We solve the finite version of the problem, and show the hardness of the infinite
version, linking it to various areas and open problems in mathematics and computer
science: β-expansions, discounted-sum automata, piecewise affine maps, and generalizations
of the Cantor set. We provide some partial results to the infinite version, among
which are solutions to its restriction to eventually-periodic sequences and to
the cases that λ λ 1/2 or λ = 1/n, for every n ε N. We use our results for solving
some open problems on discounted-sum automata, among which are the exact-value
problem for nondeterministic automata over finite words and the universality and
inclusion problems for functional automata.'
acknowledgement: 'A technical report of the article is available at: https://research-explorer.app.ist.ac.at/record/5439'
article_processing_charge: No
author:
- first_name: Udi
full_name: Boker, Udi
id: 31E297B6-F248-11E8-B48F-1D18A9856A87
last_name: Boker
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
citation:
ama: 'Boker U, Henzinger TA, Otop J. The target discounted-sum problem. In: LICS.
Logic in Computer Science. IEEE; 2015:750-761. doi:10.1109/LICS.2015.74'
apa: 'Boker, U., Henzinger, T. A., & Otop, J. (2015). The target discounted-sum
problem. In LICS (pp. 750–761). Kyoto, Japan: IEEE. https://doi.org/10.1109/LICS.2015.74'
chicago: Boker, Udi, Thomas A Henzinger, and Jan Otop. “The Target Discounted-Sum
Problem.” In LICS, 750–61. Logic in Computer Science. IEEE, 2015. https://doi.org/10.1109/LICS.2015.74.
ieee: U. Boker, T. A. Henzinger, and J. Otop, “The target discounted-sum problem,”
in LICS, Kyoto, Japan, 2015, pp. 750–761.
ista: 'Boker U, Henzinger TA, Otop J. 2015. The target discounted-sum problem. LICS.
LICS: Logic in Computer ScienceLogic in Computer Science, 750–761.'
mla: Boker, Udi, et al. “The Target Discounted-Sum Problem.” LICS, IEEE,
2015, pp. 750–61, doi:10.1109/LICS.2015.74.
short: U. Boker, T.A. Henzinger, J. Otop, in:, LICS, IEEE, 2015, pp. 750–761.
conference:
end_date: 2015-07-10
location: Kyoto, Japan
name: 'LICS: Logic in Computer Science'
start_date: 2015-007-06
date_created: 2018-12-11T11:53:19Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2023-02-23T12:26:27Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1109/LICS.2015.74
ec_funded: 1
file:
- access_level: open_access
checksum: 6abebca9c1a620e9e103a8f9222befac
content_type: application/pdf
creator: dernst
date_created: 2020-05-15T08:53:29Z
date_updated: 2020-07-14T12:45:10Z
file_id: '7852'
file_name: 2015_LICS_Boker.pdf
file_size: 340215
relation: main_file
file_date_updated: 2020-07-14T12:45:10Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 750 - 761
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: LICS
publication_identifier:
eisbn:
- '978-1-4799-8875-4 '
issn:
- '1043-6871 '
publication_status: published
publisher: IEEE
publist_id: '5491'
quality_controlled: '1'
related_material:
record:
- id: '5439'
relation: earlier_version
status: public
scopus_import: 1
series_title: Logic in Computer Science
status: public
title: The target discounted-sum problem
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1610'
abstract:
- lang: eng
text: The edit distance between two words w1, w2 is the minimal number of word operations
(letter insertions, deletions, and substitutions) necessary to transform w1 to
w2. The edit distance generalizes to languages L1,L2, where the edit distance
is the minimal number k such that for every word from L1 there exists a word in
L2 with edit distance at most k. We study the edit distance computation problem
between pushdown automata and their subclasses. The problem of computing edit
distance to pushdown automata is undecidable, and in practice, the interesting
question is to compute the edit distance from a pushdown automaton (the implementation,
a standard model for programs with recursion) to a regular language (the specification).
In this work, we present a complete picture of decidability and complexity for
deciding whether, for a given threshold k, the edit distance from a pushdown automaton
to a finite automaton is at most k.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
citation:
ama: 'Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. Edit distance for pushdown
automata. In: 42nd International Colloquium. Vol 9135. Springer Nature;
2015:121-133. doi:10.1007/978-3-662-47666-6_10'
apa: 'Chatterjee, K., Henzinger, T. A., Ibsen-Jensen, R., & Otop, J. (2015).
Edit distance for pushdown automata. In 42nd International Colloquium (Vol.
9135, pp. 121–133). Kyoto, Japan: Springer Nature. https://doi.org/10.1007/978-3-662-47666-6_10'
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, Rasmus Ibsen-Jensen, and Jan
Otop. “Edit Distance for Pushdown Automata.” In 42nd International Colloquium,
9135:121–33. Springer Nature, 2015. https://doi.org/10.1007/978-3-662-47666-6_10.
ieee: K. Chatterjee, T. A. Henzinger, R. Ibsen-Jensen, and J. Otop, “Edit distance
for pushdown automata,” in 42nd International Colloquium, Kyoto, Japan,
2015, vol. 9135, no. Part II, pp. 121–133.
ista: 'Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. 2015. Edit distance for
pushdown automata. 42nd International Colloquium. ICALP: Automata, Languages and
Programming, LNCS, vol. 9135, 121–133.'
mla: Chatterjee, Krishnendu, et al. “Edit Distance for Pushdown Automata.” 42nd
International Colloquium, vol. 9135, no. Part II, Springer Nature, 2015, pp.
121–33, doi:10.1007/978-3-662-47666-6_10.
short: K. Chatterjee, T.A. Henzinger, R. Ibsen-Jensen, J. Otop, in:, 42nd International
Colloquium, Springer Nature, 2015, pp. 121–133.
conference:
end_date: 2015-07-10
location: Kyoto, Japan
name: 'ICALP: Automata, Languages and Programming'
start_date: 2015-07-06
date_created: 2018-12-11T11:53:01Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2023-02-23T12:26:24Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1007/978-3-662-47666-6_10
ec_funded: 1
external_id:
arxiv:
- '1504.08259'
intvolume: ' 9135'
issue: Part II
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1504.08259
month: '07'
oa: 1
oa_version: None
page: 121 - 133
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication: 42nd International Colloquium
publication_identifier:
isbn:
- 978-3-662-47665-9
publication_status: published
publisher: Springer Nature
publist_id: '5556'
pubrep_id: '321'
quality_controlled: '1'
related_material:
record:
- id: '465'
relation: later_version
status: public
- id: '5438'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Edit distance for pushdown automata
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 9135
year: '2015'
...
---
_id: '5437'
abstract:
- lang: eng
text: "We consider the core algorithmic problems related to verification of systems
with respect to three classical quantitative properties, namely, the mean-payoff
property, the ratio property, and the minimum initial credit for energy property.
\r\nThe algorithmic problem given a graph and a quantitative property asks to
compute the optimal value (the infimum value over all traces) from every node
of the graph. We consider graphs with constant treewidth, and it is well-known
that the control-flow graphs of most programs have constant treewidth. Let $n$
denote the number of nodes of a graph, $m$ the number of edges (for constant treewidth
graphs $m=O(n)$) and $W$ the largest absolute value of the weights.\r\nOur main
theoretical results are as follows.\r\nFirst, for constant treewidth graphs we
present an algorithm that approximates the mean-payoff value within a multiplicative
factor of $\\epsilon$ in time $O(n \\cdot \\log (n/\\epsilon))$ and linear space,
as compared to the classical algorithms that require quadratic time. Second, for
the ratio property we present an algorithm that for constant treewidth graphs
works in time $O(n \\cdot \\log (|a\\cdot b|))=O(n\\cdot\\log (n\\cdot W))$, when
the output is $\\frac{a}{b}$, as compared to the previously best known algorithm
with running time $O(n^2 \\cdot \\log (n\\cdot W))$. Third, for the minimum initial
credit problem we show that (i)~for general graphs the problem can be solved in
$O(n^2\\cdot m)$ time and the associated decision problem can be solved in $O(n\\cdot
m)$ time, improving the previous known $O(n^3\\cdot m\\cdot \\log (n\\cdot W))$
and $O(n^2 \\cdot m)$ bounds, respectively; and (ii)~for constant treewidth graphs
we present an algorithm that requires $O(n\\cdot \\log n)$ time, improving the
previous known $O(n^4 \\cdot \\log (n \\cdot W))$ bound.\r\nWe have implemented
some of our algorithms and show that they present a significant speedup on standard
benchmarks. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Faster Algorithms for Quantitative
Verification in Constant Treewidth Graphs. IST Austria; 2015. doi:10.15479/AT:IST-2015-330-v2-1
apa: Chatterjee, K., Ibsen-Jensen, R., & Pavlogiannis, A. (2015). Faster
algorithms for quantitative verification in constant treewidth graphs. IST
Austria. https://doi.org/10.15479/AT:IST-2015-330-v2-1
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis.
Faster Algorithms for Quantitative Verification in Constant Treewidth Graphs.
IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-330-v2-1.
ieee: K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, Faster algorithms
for quantitative verification in constant treewidth graphs. IST Austria, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2015. Faster algorithms for
quantitative verification in constant treewidth graphs, IST Austria, 27p.
mla: Chatterjee, Krishnendu, et al. Faster Algorithms for Quantitative Verification
in Constant Treewidth Graphs. IST Austria, 2015, doi:10.15479/AT:IST-2015-330-v2-1.
short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, Faster Algorithms for Quantitative
Verification in Constant Treewidth Graphs, IST Austria, 2015.
date_created: 2018-12-12T11:39:19Z
date_published: 2015-04-27T00:00:00Z
date_updated: 2023-02-23T12:26:05Z
day: '27'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-330-v2-1
file:
- access_level: open_access
checksum: f5917c20f84018b362d385c000a2e123
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:12Z
date_updated: 2020-07-14T12:46:54Z
file_id: '5473'
file_name: IST-2015-330-v2+1_main.pdf
file_size: 1072137
relation: main_file
file_date_updated: 2020-07-14T12:46:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '27'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '333'
related_material:
record:
- id: '1607'
relation: later_version
status: public
- id: '5430'
relation: earlier_version
status: public
status: public
title: Faster algorithms for quantitative verification in constant treewidth graphs
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5430'
abstract:
- lang: eng
text: We consider the core algorithmic problems related to verification of systems
with respect to three classical quantitative properties, namely, the mean- payoff
property, the ratio property, and the minimum initial credit for energy property.
The algorithmic problem given a graph and a quantitative property asks to compute
the optimal value (the infimum value over all traces) from every node of the graph.
We consider graphs with constant treewidth, and it is well-known that the control-flow
graphs of most programs have constant treewidth. Let n denote the number of nodes
of a graph, m the number of edges (for constant treewidth graphs m = O ( n ) )
and W the largest absolute value of the weights. Our main theoretical results
are as follows. First, for constant treewidth graphs we present an algorithm that
approximates the mean-payoff value within a mul- tiplicative factor of ∊ in time
O ( n · log( n/∊ )) and linear space, as compared to the classical algorithms
that require quadratic time. Second, for the ratio property we present an algorithm
that for constant treewidth graphs works in time O ( n · log( | a · b · n | ))
= O ( n · log( n · W )) , when the output is a b , as compared to the previously
best known algorithm with running time O ( n 2 · log( n · W )) . Third, for the
minimum initial credit problem we show that (i) for general graphs the problem
can be solved in O ( n 2 · m ) time and the associated decision problem can be
solved in O ( n · m ) time, improving the previous known O ( n 3 · m · log( n
· W )) and O ( n 2 · m ) bounds, respectively; and (ii) for constant treewidth
graphs we present an algorithm that requires O ( n · log n ) time, improving the
previous known O ( n 4 · log( n · W )) bound. We have implemented some of our
algorithms and show that they present a significant speedup on standard benchmarks.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Faster Algorithms for Quantitative
Verification in Constant Treewidth Graphs. IST Austria; 2015. doi:10.15479/AT:IST-2015-319-v1-1
apa: Chatterjee, K., Ibsen-Jensen, R., & Pavlogiannis, A. (2015). Faster
algorithms for quantitative verification in constant treewidth graphs. IST
Austria. https://doi.org/10.15479/AT:IST-2015-319-v1-1
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis.
Faster Algorithms for Quantitative Verification in Constant Treewidth Graphs.
IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-319-v1-1.
ieee: K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, Faster algorithms
for quantitative verification in constant treewidth graphs. IST Austria, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2015. Faster algorithms for
quantitative verification in constant treewidth graphs, IST Austria, 31p.
mla: Chatterjee, Krishnendu, et al. Faster Algorithms for Quantitative Verification
in Constant Treewidth Graphs. IST Austria, 2015, doi:10.15479/AT:IST-2015-319-v1-1.
short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, Faster Algorithms for Quantitative
Verification in Constant Treewidth Graphs, IST Austria, 2015.
date_created: 2018-12-12T11:39:17Z
date_published: 2015-02-10T00:00:00Z
date_updated: 2023-02-23T12:26:22Z
day: '10'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-319-v1-1
file:
- access_level: open_access
checksum: 62c6ea01e342553dcafb88a070fb1ad5
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:21Z
date_updated: 2020-07-14T12:46:52Z
file_id: '5482'
file_name: IST-2015-319-v1+1_long.pdf
file_size: 1089651
relation: main_file
file_date_updated: 2020-07-14T12:46:52Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '31'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '319'
related_material:
record:
- id: '1607'
relation: later_version
status: public
- id: '5437'
relation: later_version
status: public
status: public
title: Faster algorithms for quantitative verification in constant treewidth graphs
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5439'
abstract:
- lang: eng
text: 'The target discounted-sum problem is the following: Given a rational discount
factor 0 < λ < 1 and three rational values a, b, and t, does there exist a finite
or an infinite sequence w ε(a, b)∗ or w ε(a, b)w, such that Σ|w| i=0 w(i)λi equals
t? The problem turns out to relate to many fields of mathematics and computer
science, and its decidability question is surprisingly hard to solve. We solve
the finite version of the problem, and show the hardness of the infinite version,
linking it to various areas and open problems in mathematics and computer science:
β-expansions, discounted-sum automata, piecewise affine maps, and generalizations
of the Cantor set. We provide some partial results to the infinite version, among
which are solutions to its restriction to eventually-periodic sequences and to
the cases that λ λ 1/2 or λ = 1/n, for every n ε N. We use our results for solving
some open problems on discounted-sum automata, among which are the exact-value
problem for nondeterministic automata over finite words and the universality and
inclusion problems for functional automata. '
alternative_title:
- IST Austria Technical Report
author:
- first_name: Udi
full_name: Boker, Udi
id: 31E297B6-F248-11E8-B48F-1D18A9856A87
last_name: Boker
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
citation:
ama: Boker U, Henzinger TA, Otop J. The Target Discounted-Sum Problem. IST
Austria; 2015. doi:10.15479/AT:IST-2015-335-v1-1
apa: Boker, U., Henzinger, T. A., & Otop, J. (2015). The target discounted-sum
problem. IST Austria. https://doi.org/10.15479/AT:IST-2015-335-v1-1
chicago: Boker, Udi, Thomas A Henzinger, and Jan Otop. The Target Discounted-Sum
Problem. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-335-v1-1.
ieee: U. Boker, T. A. Henzinger, and J. Otop, The target discounted-sum problem.
IST Austria, 2015.
ista: Boker U, Henzinger TA, Otop J. 2015. The target discounted-sum problem, IST
Austria, 20p.
mla: Boker, Udi, et al. The Target Discounted-Sum Problem. IST Austria, 2015,
doi:10.15479/AT:IST-2015-335-v1-1.
short: U. Boker, T.A. Henzinger, J. Otop, The Target Discounted-Sum Problem, IST
Austria, 2015.
date_created: 2018-12-12T11:39:20Z
date_published: 2015-05-18T00:00:00Z
date_updated: 2023-02-23T10:08:48Z
day: '18'
ddc:
- '004'
- '512'
- '513'
department:
- _id: ToHe
doi: 10.15479/AT:IST-2015-335-v1-1
file:
- access_level: open_access
checksum: 40405907aa012acece1bc26cf0be554d
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:55Z
date_updated: 2020-07-14T12:46:55Z
file_id: '5517'
file_name: IST-2015-335-v1+1_report.pdf
file_size: 589619
relation: main_file
file_date_updated: 2020-07-14T12:46:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '20'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '335'
related_material:
record:
- id: '1659'
relation: later_version
status: public
status: public
title: The target discounted-sum problem
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5438'
abstract:
- lang: eng
text: "The edit distance between two words w1, w2 is the minimal number of word
operations (letter insertions, deletions, and substitutions) necessary to transform
w1 to w2. The edit distance generalizes to languages L1, L2, where the edit distance
is the minimal number k such that for every word from L1 there exists a word in
L2 with edit distance at most k. We study the edit distance computation problem
between pushdown automata and their subclasses.\r\nThe problem of computing edit
distance to a pushdown automaton is undecidable, and in practice, the interesting
question is to compute the edit distance from a pushdown automaton (the implementation,
a standard model for programs with recursion) to a regular language (the specification).
In this work, we present a complete picture of decidability and complexity for
deciding whether, for a given threshold k, the edit distance from a pushdown automaton
to a finite automaton is at most k. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Jan
full_name: Otop, Jan
id: 2FC5DA74-F248-11E8-B48F-1D18A9856A87
last_name: Otop
citation:
ama: Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. Edit Distance for Pushdown
Automata. IST Austria; 2015. doi:10.15479/AT:IST-2015-334-v1-1
apa: Chatterjee, K., Henzinger, T. A., Ibsen-Jensen, R., & Otop, J. (2015).
Edit distance for pushdown automata. IST Austria. https://doi.org/10.15479/AT:IST-2015-334-v1-1
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, Rasmus Ibsen-Jensen, and Jan
Otop. Edit Distance for Pushdown Automata. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-334-v1-1.
ieee: K. Chatterjee, T. A. Henzinger, R. Ibsen-Jensen, and J. Otop, Edit distance
for pushdown automata. IST Austria, 2015.
ista: Chatterjee K, Henzinger TA, Ibsen-Jensen R, Otop J. 2015. Edit distance for
pushdown automata, IST Austria, 15p.
mla: Chatterjee, Krishnendu, et al. Edit Distance for Pushdown Automata.
IST Austria, 2015, doi:10.15479/AT:IST-2015-334-v1-1.
short: K. Chatterjee, T.A. Henzinger, R. Ibsen-Jensen, J. Otop, Edit Distance for
Pushdown Automata, IST Austria, 2015.
date_created: 2018-12-12T11:39:20Z
date_published: 2015-05-05T00:00:00Z
date_updated: 2023-02-23T12:20:08Z
day: '05'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-334-v1-1
file:
- access_level: open_access
checksum: 8a5f2d77560e552af87eb1982437a43b
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:56Z
date_updated: 2020-07-14T12:46:55Z
file_id: '5518'
file_name: IST-2015-334-v1+1_report.pdf
file_size: 422573
relation: main_file
file_date_updated: 2020-07-14T12:46:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '15'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '334'
related_material:
record:
- id: '1610'
relation: later_version
status: public
- id: '465'
relation: later_version
status: public
status: public
title: Edit distance for pushdown automata
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5440'
abstract:
- lang: eng
text: 'Evolution occurs in populations of reproducing individuals. The structure
of the population affects the outcome of the evolutionary process. Evolutionary
graph theory is a powerful approach to study this phenomenon. There are two graphs.
The interaction graph specifies who interacts with whom for payoff in the context
of evolution. The replacement graph specifies who competes with whom for reproduction.
The vertices of the two graphs are the same, and each vertex corresponds to an
individual of the population. The fitness (or the reproductive rate) is a non-negative
number, and depends on the payoff. A key quantity is the fixation probability
of a new mutant. It is defined as the probability that a newly introduced mutant
(on a single vertex) generates a lineage of offspring which eventually takes over
the entire population of resident individuals. The basic computational questions
are as follows: (i) the qualitative question asks whether the fixation probability
is positive; and (ii) the quantitative approximation question asks for an approximation
of the fixation probability. Our main results are as follows: First, we consider
a special case of the general problem, where the residents do not reproduce. We
show that the qualitative question is NP-complete, and the quantitative approximation
question is #P-complete, and the hardness results hold even in the special case
where the interaction and the replacement graphs coincide. Second, we show that
in general both the qualitative and the quantitative approximation questions are
PSPACE-complete. The PSPACE-hardness result for quantitative approximation holds
even when the fitness is always positive.'
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Chatterjee K, Ibsen-Jensen R, Nowak M. The Complexity of Evolutionary Games
on Graphs. IST Austria; 2015. doi:10.15479/AT:IST-2015-323-v2-2
apa: Chatterjee, K., Ibsen-Jensen, R., & Nowak, M. (2015). The complexity
of evolutionary games on graphs. IST Austria. https://doi.org/10.15479/AT:IST-2015-323-v2-2
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Martin Nowak. The Complexity
of Evolutionary Games on Graphs. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-323-v2-2.
ieee: K. Chatterjee, R. Ibsen-Jensen, and M. Nowak, The complexity of evolutionary
games on graphs. IST Austria, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Nowak M. 2015. The complexity of evolutionary
games on graphs, IST Austria, 18p.
mla: Chatterjee, Krishnendu, et al. The Complexity of Evolutionary Games on Graphs.
IST Austria, 2015, doi:10.15479/AT:IST-2015-323-v2-2.
short: K. Chatterjee, R. Ibsen-Jensen, M. Nowak, The Complexity of Evolutionary
Games on Graphs, IST Austria, 2015.
date_created: 2018-12-12T11:39:21Z
date_published: 2015-06-16T00:00:00Z
date_updated: 2023-02-23T12:26:10Z
day: '16'
ddc:
- '005'
- '576'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-323-v2-2
file:
- access_level: open_access
checksum: 66aace7d367032af97c15e35c9be9636
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:23Z
date_updated: 2020-07-14T12:46:56Z
file_id: '5484'
file_name: IST-2015-323-v2+2_main.pdf
file_size: 466161
relation: main_file
file_date_updated: 2020-07-14T12:46:56Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '18'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '338'
related_material:
record:
- id: '5421'
relation: earlier_version
status: public
- id: '5432'
relation: earlier_version
status: public
status: public
title: The complexity of evolutionary games on graphs
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5432'
abstract:
- lang: eng
text: "Evolution occurs in populations of reproducing individuals. The structure
of the population affects the outcome of the evolutionary process. Evolutionary
graph theory is a powerful approach to study this phenomenon. There are two graphs.
The interaction graph specifies who interacts with whom in the context of evolution.The
replacement graph specifies who competes with whom for reproduction. \r\nThe vertices
of the two graphs are the same, and each vertex corresponds to an individual of
the population. A key quantity is the fixation probability of a new mutant. It
is defined as the probability that a newly introduced mutant (on a single vertex)
generates a lineage of offspring which eventually takes over the entire population
of resident individuals. The basic computational questions are as follows: (i)
the qualitative question asks whether the fixation probability is positive; and
(ii) the quantitative approximation question asks for an approximation of the
fixation probability. \r\nOur main results are:\r\n(1) We show that the qualitative
question is NP-complete and the quantitative approximation question is #P-hard
in the special case when the interaction and the replacement graphs coincide and
even with the restriction that the resident individuals do not reproduce (which
corresponds to an invading population taking over an empty structure).\r\n(2)
We show that in general the qualitative question is PSPACE-complete and the quantitative
approximation question is PSPACE-hard and can be solved in exponential time.\r\n"
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Chatterjee K, Ibsen-Jensen R, Nowak M. The Complexity of Evolutionary Games
on Graphs. IST Austria; 2015. doi:10.15479/AT:IST-2015-323-v1-1
apa: Chatterjee, K., Ibsen-Jensen, R., & Nowak, M. (2015). The complexity
of evolutionary games on graphs. IST Austria. https://doi.org/10.15479/AT:IST-2015-323-v1-1
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Martin Nowak. The Complexity
of Evolutionary Games on Graphs. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-323-v1-1.
ieee: K. Chatterjee, R. Ibsen-Jensen, and M. Nowak, The complexity of evolutionary
games on graphs. IST Austria, 2015.
ista: Chatterjee K, Ibsen-Jensen R, Nowak M. 2015. The complexity of evolutionary
games on graphs, IST Austria, 29p.
mla: Chatterjee, Krishnendu, et al. The Complexity of Evolutionary Games on Graphs.
IST Austria, 2015, doi:10.15479/AT:IST-2015-323-v1-1.
short: K. Chatterjee, R. Ibsen-Jensen, M. Nowak, The Complexity of Evolutionary
Games on Graphs, IST Austria, 2015.
date_created: 2018-12-12T11:39:18Z
date_published: 2015-02-19T00:00:00Z
date_updated: 2023-02-23T12:26:33Z
day: '19'
ddc:
- '005'
- '576'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-323-v1-1
file:
- access_level: open_access
checksum: 546c1b291d545e7b24aaaf4199dac671
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:57Z
date_updated: 2020-07-14T12:46:53Z
file_id: '5519'
file_name: IST-2015-323-v1+1_main.pdf
file_size: 576347
relation: main_file
file_date_updated: 2020-07-14T12:46:53Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '29'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '323'
related_material:
record:
- id: '5421'
relation: earlier_version
status: public
- id: '5440'
relation: later_version
status: public
status: public
title: The complexity of evolutionary games on graphs
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5444'
abstract:
- lang: eng
text: A comprehensive understanding of the clonal evolution of cancer is critical
for understanding neoplasia. Genome-wide sequencing data enables evolutionary
studies at unprecedented depth. However, classical phylogenetic methods often
struggle with noisy sequencing data of impure DNA samples and fail to detect subclones
that have different evolutionary trajectories. We have developed a tool, called
Treeomics, that allows us to reconstruct the phylogeny of a cancer with commonly
available sequencing technologies. Using Bayesian inference and Integer Linear
Programming, robust phylogenies consistent with the biological processes underlying
cancer evolution were obtained for pancreatic, ovarian, and prostate cancers.
Furthermore, Treeomics correctly identified sequencing artifacts such as those
resulting from low statistical power; nearly 7% of variants were misclassified
by conventional statistical methods. These artifacts can skew phylogenies by creating
illusory tumor heterogeneity among distinct samples. Importantly, we show that
the evolutionary trees generated with Treeomics are mathematically optimal.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Alvin
full_name: Makohon-Moore, Alvin
last_name: Makohon-Moore
- first_name: Jeffrey
full_name: Gerold, Jeffrey
last_name: Gerold
- first_name: Ivana
full_name: Bozic, Ivana
last_name: Bozic
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Christine
full_name: Iacobuzio-Donahue, Christine
last_name: Iacobuzio-Donahue
- first_name: Bert
full_name: Vogelstein, Bert
last_name: Vogelstein
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Reiter J, Makohon-Moore A, Gerold J, et al. Reconstructing Robust Phylogenies
of Metastatic Cancers. IST Austria; 2015. doi:10.15479/AT:IST-2015-399-v1-1
apa: Reiter, J., Makohon-Moore, A., Gerold, J., Bozic, I., Chatterjee, K., Iacobuzio-Donahue,
C., … Nowak, M. (2015). Reconstructing robust phylogenies of metastatic cancers.
IST Austria. https://doi.org/10.15479/AT:IST-2015-399-v1-1
chicago: Reiter, Johannes, Alvin Makohon-Moore, Jeffrey Gerold, Ivana Bozic, Krishnendu
Chatterjee, Christine Iacobuzio-Donahue, Bert Vogelstein, and Martin Nowak. Reconstructing
Robust Phylogenies of Metastatic Cancers. IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-399-v1-1.
ieee: J. Reiter et al., Reconstructing robust phylogenies of metastatic
cancers. IST Austria, 2015.
ista: Reiter J, Makohon-Moore A, Gerold J, Bozic I, Chatterjee K, Iacobuzio-Donahue
C, Vogelstein B, Nowak M. 2015. Reconstructing robust phylogenies of metastatic
cancers, IST Austria, 25p.
mla: Reiter, Johannes, et al. Reconstructing Robust Phylogenies of Metastatic
Cancers. IST Austria, 2015, doi:10.15479/AT:IST-2015-399-v1-1.
short: J. Reiter, A. Makohon-Moore, J. Gerold, I. Bozic, K. Chatterjee, C. Iacobuzio-Donahue,
B. Vogelstein, M. Nowak, Reconstructing Robust Phylogenies of Metastatic Cancers,
IST Austria, 2015.
date_created: 2018-12-12T11:39:22Z
date_published: 2015-12-30T00:00:00Z
date_updated: 2020-07-14T23:05:07Z
day: '30'
ddc:
- '000'
- '576'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-399-v1-1
file:
- access_level: open_access
checksum: c47d33bdda06181753c0af36f16e7b5d
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:24Z
date_updated: 2020-07-14T12:46:58Z
file_id: '5485'
file_name: IST-2015-399-v1+1_treeomics.pdf
file_size: 3533200
relation: main_file
file_date_updated: 2020-07-14T12:46:58Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '25'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '399'
status: public
title: Reconstructing robust phylogenies of metastatic cancers
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5443'
abstract:
- lang: eng
text: POMDPs are standard models for probabilistic planning problems, where an agent
interacts with an uncertain environment. We study the problem of almost-sure reachability,
where given a set of target states, the question is to decide whether there is
a policy to ensure that the target set is reached with probability 1 (almost-surely).
While in general the problem is EXPTIME-complete, in many practical cases policies
with a small amount of memory suffice. Moreover, the existing solution to the
problem is explicit, which first requires to construct explicitly an exponential
reduction to a belief-support MDP. In this work, we first study the existence
of observation-stationary strategies, which is NP-complete, and then small-memory
strategies. We present a symbolic algorithm by an efficient encoding to SAT and
using a SAT solver for the problem. We report experimental results demonstrating
the scalability of our symbolic (SAT-based) approach.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Chmelik, Martin
id: 3624234E-F248-11E8-B48F-1D18A9856A87
last_name: Chmelik
- first_name: Jessica
full_name: Davies, Jessica
id: 378E0060-F248-11E8-B48F-1D18A9856A87
last_name: Davies
citation:
ama: Chatterjee K, Chmelik M, Davies J. A Symbolic SAT-Based Algorithm for Almost-Sure
Reachability with Small Strategies in POMDPs. IST Austria; 2015. doi:10.15479/AT:IST-2015-325-v2-1
apa: Chatterjee, K., Chmelik, M., & Davies, J. (2015). A symbolic SAT-based
algorithm for almost-sure reachability with small strategies in POMDPs. IST
Austria. https://doi.org/10.15479/AT:IST-2015-325-v2-1
chicago: Chatterjee, Krishnendu, Martin Chmelik, and Jessica Davies. A Symbolic
SAT-Based Algorithm for Almost-Sure Reachability with Small Strategies in POMDPs.
IST Austria, 2015. https://doi.org/10.15479/AT:IST-2015-325-v2-1.
ieee: K. Chatterjee, M. Chmelik, and J. Davies, A symbolic SAT-based algorithm
for almost-sure reachability with small strategies in POMDPs. IST Austria,
2015.
ista: Chatterjee K, Chmelik M, Davies J. 2015. A symbolic SAT-based algorithm for
almost-sure reachability with small strategies in POMDPs, IST Austria, 23p.
mla: Chatterjee, Krishnendu, et al. A Symbolic SAT-Based Algorithm for Almost-Sure
Reachability with Small Strategies in POMDPs. IST Austria, 2015, doi:10.15479/AT:IST-2015-325-v2-1.
short: K. Chatterjee, M. Chmelik, J. Davies, A Symbolic SAT-Based Algorithm for
Almost-Sure Reachability with Small Strategies in POMDPs, IST Austria, 2015.
date_created: 2018-12-12T11:39:22Z
date_published: 2015-11-06T00:00:00Z
date_updated: 2023-02-21T16:24:05Z
day: '06'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2015-325-v2-1
file:
- access_level: open_access
checksum: f0fa31ad8161ed655137e94012123ef9
content_type: application/pdf
creator: system
date_created: 2018-12-12T11:53:05Z
date_updated: 2020-07-14T12:46:57Z
file_id: '5466'
file_name: IST-2015-325-v2+1_main.pdf
file_size: 412379
relation: main_file
file_date_updated: 2020-07-14T12:46:57Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '23'
publication_identifier:
issn:
- 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '362'
related_material:
record:
- id: '1166'
relation: later_version
status: public
status: public
title: A symbolic SAT-based algorithm for almost-sure reachability with small strategies
in POMDPs
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '5804'
abstract:
- lang: eng
text: We present here the first integer-based algorithm for constructing a well-defined
lattice sphere specified by integer radius and integer center. The algorithm evolves
from a unique correspondence between the lattice points comprising the sphere
and the distribution of sum of three square numbers in integer intervals. We characterize
these intervals to derive a useful set of recurrences, which, in turn, aids in
efficient computation. Each point of the lattice sphere is determined by resorting
to only a few primitive operations in the integer domain. The symmetry of its
quadraginta octants provides an added advantage by confining the computation to
its prima quadraginta octant. Detailed theoretical analysis and experimental results
have been furnished to demonstrate its simplicity and elegance.
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Partha
full_name: Bhowmick, Partha
last_name: Bhowmick
citation:
ama: Biswas R, Bhowmick P. From prima quadraginta octant to lattice sphere through
primitive integer operations. Theoretical Computer Science. 2015;624(4):56-72.
doi:10.1016/j.tcs.2015.11.018
apa: Biswas, R., & Bhowmick, P. (2015). From prima quadraginta octant to lattice
sphere through primitive integer operations. Theoretical Computer Science.
Elsevier. https://doi.org/10.1016/j.tcs.2015.11.018
chicago: Biswas, Ranita, and Partha Bhowmick. “From Prima Quadraginta Octant to
Lattice Sphere through Primitive Integer Operations.” Theoretical Computer
Science. Elsevier, 2015. https://doi.org/10.1016/j.tcs.2015.11.018.
ieee: R. Biswas and P. Bhowmick, “From prima quadraginta octant to lattice sphere
through primitive integer operations,” Theoretical Computer Science, vol.
624, no. 4. Elsevier, pp. 56–72, 2015.
ista: Biswas R, Bhowmick P. 2015. From prima quadraginta octant to lattice sphere
through primitive integer operations. Theoretical Computer Science. 624(4), 56–72.
mla: Biswas, Ranita, and Partha Bhowmick. “From Prima Quadraginta Octant to Lattice
Sphere through Primitive Integer Operations.” Theoretical Computer Science,
vol. 624, no. 4, Elsevier, 2015, pp. 56–72, doi:10.1016/j.tcs.2015.11.018.
short: R. Biswas, P. Bhowmick, Theoretical Computer Science 624 (2015) 56–72.
date_created: 2019-01-08T20:44:06Z
date_published: 2015-04-18T00:00:00Z
date_updated: 2021-01-12T08:03:36Z
day: '18'
doi: 10.1016/j.tcs.2015.11.018
extern: '1'
intvolume: ' 624'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 56-72
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: From prima quadraginta octant to lattice sphere through primitive integer operations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 624
year: '2015'
...
---
_id: '5807'
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Partha
full_name: Bhowmick, Partha
last_name: Bhowmick
citation:
ama: Biswas R, Bhowmick P. On different topological classes of spherical geodesic
paths and circles inZ3. Theoretical Computer Science. 2015;605(11):146-163.
doi:10.1016/j.tcs.2015.09.003
apa: Biswas, R., & Bhowmick, P. (2015). On different topological classes of
spherical geodesic paths and circles inZ3. Theoretical Computer Science.
Elsevier. https://doi.org/10.1016/j.tcs.2015.09.003
chicago: Biswas, Ranita, and Partha Bhowmick. “On Different Topological Classes
of Spherical Geodesic Paths and Circles InZ3.” Theoretical Computer Science.
Elsevier, 2015. https://doi.org/10.1016/j.tcs.2015.09.003.
ieee: R. Biswas and P. Bhowmick, “On different topological classes of spherical
geodesic paths and circles inZ3,” Theoretical Computer Science, vol. 605,
no. 11. Elsevier, pp. 146–163, 2015.
ista: Biswas R, Bhowmick P. 2015. On different topological classes of spherical
geodesic paths and circles inZ3. Theoretical Computer Science. 605(11), 146–163.
mla: Biswas, Ranita, and Partha Bhowmick. “On Different Topological Classes of Spherical
Geodesic Paths and Circles InZ3.” Theoretical Computer Science, vol. 605,
no. 11, Elsevier, 2015, pp. 146–63, doi:10.1016/j.tcs.2015.09.003.
short: R. Biswas, P. Bhowmick, Theoretical Computer Science 605 (2015) 146–163.
date_created: 2019-01-08T20:44:52Z
date_published: 2015-11-09T00:00:00Z
date_updated: 2021-01-12T08:03:37Z
day: '09'
doi: 10.1016/j.tcs.2015.09.003
extern: '1'
intvolume: ' 605'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 146-163
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: On different topological classes of spherical geodesic paths and circles inZ3
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 605
year: '2015'
...
---
_id: '5808'
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Partha
full_name: Bhowmick, Partha
last_name: Bhowmick
citation:
ama: Biswas R, Bhowmick P. Layer the sphere. The Visual Computer. 2015;31(6-8):787-797.
doi:10.1007/s00371-015-1101-3
apa: Biswas, R., & Bhowmick, P. (2015). Layer the sphere. The Visual Computer.
Springer Nature. https://doi.org/10.1007/s00371-015-1101-3
chicago: Biswas, Ranita, and Partha Bhowmick. “Layer the Sphere.” The Visual
Computer. Springer Nature, 2015. https://doi.org/10.1007/s00371-015-1101-3.
ieee: R. Biswas and P. Bhowmick, “Layer the sphere,” The Visual Computer,
vol. 31, no. 6–8. Springer Nature, pp. 787–797, 2015.
ista: Biswas R, Bhowmick P. 2015. Layer the sphere. The Visual Computer. 31(6–8),
787–797.
mla: Biswas, Ranita, and Partha Bhowmick. “Layer the Sphere.” The Visual Computer,
vol. 31, no. 6–8, Springer Nature, 2015, pp. 787–97, doi:10.1007/s00371-015-1101-3.
short: R. Biswas, P. Bhowmick, The Visual Computer 31 (2015) 787–797.
date_created: 2019-01-08T20:45:05Z
date_published: 2015-05-08T00:00:00Z
date_updated: 2021-01-12T08:03:37Z
day: '08'
doi: 10.1007/s00371-015-1101-3
extern: '1'
intvolume: ' 31'
issue: 6-8
language:
- iso: eng
month: '05'
oa_version: None
page: 787-797
publication: The Visual Computer
publication_identifier:
issn:
- 0178-2789
- 1432-2315
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Layer the sphere
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2015'
...
---
_id: '594'
abstract:
- lang: eng
text: Transcription of eukaryotic protein-coding genes commences with the assembly
of a conserved initiation complex, which consists of RNA polymerase II (Pol II)
and the general transcription factors, at promoter DNA. After two decades of research,
the structural basis of transcription initiation is emerging. Crystal structures
of many components of the initiation complex have been resolved, and structural
information on Pol II complexes with general transcription factors has recently
been obtained. Although mechanistic details await elucidation, available data
outline how Pol II cooperates with the general transcription factors to bind to
and open promoter DNA, and how Pol II directs RNA synthesis and escapes from the
promoter.
article_processing_charge: No
author:
- first_name: Sarah
full_name: Sainsbury, Sarah
last_name: Sainsbury
- first_name: Carrie A
full_name: Bernecky, Carrie A
id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
last_name: Bernecky
orcid: 0000-0003-0893-7036
- first_name: Patrick
full_name: Cramer, Patrick
last_name: Cramer
citation:
ama: Sainsbury S, Bernecky C, Cramer P. Structural basis of transcription initiation
by RNA polymerase II. Nature Reviews Molecular Cell Biology. 2015;16(3):129-143.
doi:10.1038/nrm3952
apa: Sainsbury, S., Bernecky, C., & Cramer, P. (2015). Structural basis of transcription
initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology.
Nature Publishing Group. https://doi.org/10.1038/nrm3952
chicago: Sainsbury, Sarah, Carrie Bernecky, and Patrick Cramer. “Structural Basis
of Transcription Initiation by RNA Polymerase II.” Nature Reviews Molecular
Cell Biology. Nature Publishing Group, 2015. https://doi.org/10.1038/nrm3952.
ieee: S. Sainsbury, C. Bernecky, and P. Cramer, “Structural basis of transcription
initiation by RNA polymerase II,” Nature Reviews Molecular Cell Biology,
vol. 16, no. 3. Nature Publishing Group, pp. 129–143, 2015.
ista: Sainsbury S, Bernecky C, Cramer P. 2015. Structural basis of transcription
initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 16(3),
129–143.
mla: Sainsbury, Sarah, et al. “Structural Basis of Transcription Initiation by RNA
Polymerase II.” Nature Reviews Molecular Cell Biology, vol. 16, no. 3,
Nature Publishing Group, 2015, pp. 129–43, doi:10.1038/nrm3952.
short: S. Sainsbury, C. Bernecky, P. Cramer, Nature Reviews Molecular Cell Biology
16 (2015) 129–143.
date_created: 2018-12-11T11:47:23Z
date_published: 2015-03-26T00:00:00Z
date_updated: 2021-01-12T08:05:16Z
day: '26'
doi: 10.1038/nrm3952
extern: '1'
intvolume: ' 16'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 129 - 143
publication: Nature Reviews Molecular Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '7206'
status: public
title: Structural basis of transcription initiation by RNA polymerase II
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2015'
...
---
_id: '1511'
abstract:
- lang: eng
text: 'The fact that the complete graph K_5 does not embed in the plane has been
generalized in two independent directions. On the one hand, the solution of the
classical Heawood problem for graphs on surfaces established that the complete
graph K_n embeds in a closed surface M if and only if (n-3)(n-4) is at most 6b_1(M),
where b_1(M) is the first Z_2-Betti number of M. On the other hand, Van Kampen
and Flores proved that the k-skeleton of the n-dimensional simplex (the higher-dimensional
analogue of K_{n+1}) embeds in R^{2k} if and only if n is less or equal to 2k+2.
Two decades ago, Kuhnel conjectured that the k-skeleton of the n-simplex embeds
in a compact, (k-1)-connected 2k-manifold with kth Z_2-Betti number b_k only if
the following generalized Heawood inequality holds: binom{n-k-1}{k+1} is at most
binom{2k+1}{k+1} b_k. This is a common generalization of the case of graphs on
surfaces as well as the Van Kampen--Flores theorem. In the spirit of Kuhnel''s
conjecture, we prove that if the k-skeleton of the n-simplex embeds in a 2k-manifold
with kth Z_2-Betti number b_k, then n is at most 2b_k binom{2k+2}{k} + 2k + 5.
This bound is weaker than the generalized Heawood inequality, but does not require
the assumption that M is (k-1)-connected. Our proof uses a result of Volovikov
about maps that satisfy a certain homological triviality condition.'
acknowledgement: "The work by Z. P. was partially supported by the Charles University
Grant SVV-2014-260103. The\r\nwork by Z. P. and M. T. was partially supported by
the project CE-ITI (GACR P202/12/G061) of\r\nthe Czech Science Foundation and by
the ERC Advanced Grant No. 267165. Part of the research\r\nwork of M. T. was conducted
at IST Austria, supported by an IST Fellowship. The work by U.W.\r\nwas partially
supported by the Swiss National Science Foundation (grants SNSF-200020-138230 and\r\nSNSF-PP00P2-138948)."
alternative_title:
- LIPIcs
author:
- first_name: Xavier
full_name: Goaoc, Xavier
last_name: Goaoc
- first_name: Isaac
full_name: Mabillard, Isaac
id: 32BF9DAA-F248-11E8-B48F-1D18A9856A87
last_name: Mabillard
- first_name: Pavel
full_name: Paták, Pavel
last_name: Paták
- first_name: Zuzana
full_name: Patakova, Zuzana
id: 48B57058-F248-11E8-B48F-1D18A9856A87
last_name: Patakova
orcid: 0000-0002-3975-1683
- first_name: Martin
full_name: Tancer, Martin
id: 38AC689C-F248-11E8-B48F-1D18A9856A87
last_name: Tancer
orcid: 0000-0002-1191-6714
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: 'Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. On generalized
Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
result. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:476-490.
doi:10.4230/LIPIcs.SOCG.2015.476'
apa: 'Goaoc, X., Mabillard, I., Paták, P., Patakova, Z., Tancer, M., & Wagner,
U. (2015). On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type
nonembeddability result (Vol. 34, pp. 476–490). Presented at the SoCG: Symposium
on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.SOCG.2015.476'
chicago: 'Goaoc, Xavier, Isaac Mabillard, Pavel Paták, Zuzana Patakova, Martin Tancer,
and Uli Wagner. “On Generalized Heawood Inequalities for Manifolds: A Van Kampen–Flores-Type
Nonembeddability Result,” 34:476–90. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015. https://doi.org/10.4230/LIPIcs.SOCG.2015.476.'
ieee: 'X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, and U. Wagner,
“On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
result,” presented at the SoCG: Symposium on Computational Geometry, Eindhoven,
Netherlands, 2015, vol. 34, pp. 476–490.'
ista: 'Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. 2015. On generalized
Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
result. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 476–490.'
mla: 'Goaoc, Xavier, et al. On Generalized Heawood Inequalities for Manifolds:
A Van Kampen–Flores-Type Nonembeddability Result. Vol. 34, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2015, pp. 476–90, doi:10.4230/LIPIcs.SOCG.2015.476.'
short: X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:,
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 476–490.
conference:
end_date: 2015-06-25
location: Eindhoven, Netherlands
name: 'SoCG: Symposium on Computational Geometry'
start_date: 2015-06-22
date_created: 2018-12-11T11:52:27Z
date_published: 2015-06-11T00:00:00Z
date_updated: 2023-02-23T12:38:00Z
day: '11'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SOCG.2015.476
ec_funded: 1
file:
- access_level: open_access
checksum: 0945811875351796324189312ca29e9e
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:18Z
date_updated: 2020-07-14T12:44:59Z
file_id: '4871'
file_name: IST-2016-502-v1+1_42.pdf
file_size: 636735
relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 476 - 490
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5666'
pubrep_id: '502'
quality_controlled: '1'
related_material:
record:
- id: '610'
relation: later_version
status: public
scopus_import: 1
status: public
title: 'On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type
nonembeddability result'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: '34 '
year: '2015'
...
---
_id: '6118'
abstract:
- lang: eng
text: 'Carbon dioxide (CO2) gradients are ubiquitous and provide animals with information
about their environment, such as the potential presence of prey or predators.
The nematode Caenorhabditis elegans avoids elevated CO2, and previous work identified
three neuron pairs called “BAG,” “AFD,” and “ASE” that respond to CO2 stimuli.
Using in vivo Ca2+ imaging and behavioral analysis, we show that C. elegans can
detect CO2 independently of these sensory pathways. Many of the C. elegans sensory
neurons we examined, including the AWC olfactory neurons, the ASJ and ASK gustatory
neurons, and the ASH and ADL nociceptors, respond to a rise in CO2 with a rise
in Ca2+. In contrast, glial sheath cells harboring the sensory endings of C. elegans’
major chemosensory neurons exhibit strong and sustained decreases in Ca2+ in response
to high CO2. Some of these CO2 responses appear to be cell intrinsic. Worms therefore
may couple detection of CO2 to that of other cues at the earliest stages of sensory
processing. We show that C. elegans persistently suppresses oviposition at high
CO2. Hermaphrodite-specific neurons (HSNs), the executive neurons driving egg-laying,
are tonically inhibited when CO2 is elevated. CO2 modulates the egg-laying system
partly through the AWC olfactory neurons: High CO2 tonically activates AWC by
a cGMP-dependent mechanism, and AWC output inhibits the HSNs. Our work shows that
CO2 is a more complex sensory cue for C. elegans than previously thought, both
in terms of behavior and neural circuitry.'
author:
- first_name: Lorenz A.
full_name: Fenk, Lorenz A.
last_name: Fenk
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Fenk LA, de Bono M. Environmental CO2 inhibits Caenorhabditis elegans egg-laying
by modulating olfactory neurons and evokes widespread changes in neural activity.
Proceedings of the National Academy of Sciences. 2015;112(27):E3525-E3534.
doi:10.1073/pnas.1423808112
apa: Fenk, L. A., & de Bono, M. (2015). Environmental CO2 inhibits Caenorhabditis
elegans egg-laying by modulating olfactory neurons and evokes widespread changes
in neural activity. Proceedings of the National Academy of Sciences. National
Academy of Sciences. https://doi.org/10.1073/pnas.1423808112
chicago: Fenk, Lorenz A., and Mario de Bono. “Environmental CO2 Inhibits Caenorhabditis
Elegans Egg-Laying by Modulating Olfactory Neurons and Evokes Widespread Changes
in Neural Activity.” Proceedings of the National Academy of Sciences. National
Academy of Sciences, 2015. https://doi.org/10.1073/pnas.1423808112.
ieee: L. A. Fenk and M. de Bono, “Environmental CO2 inhibits Caenorhabditis elegans
egg-laying by modulating olfactory neurons and evokes widespread changes in neural
activity,” Proceedings of the National Academy of Sciences, vol. 112, no.
27. National Academy of Sciences, pp. E3525–E3534, 2015.
ista: Fenk LA, de Bono M. 2015. Environmental CO2 inhibits Caenorhabditis elegans
egg-laying by modulating olfactory neurons and evokes widespread changes in neural
activity. Proceedings of the National Academy of Sciences. 112(27), E3525–E3534.
mla: Fenk, Lorenz A., and Mario de Bono. “Environmental CO2 Inhibits Caenorhabditis
Elegans Egg-Laying by Modulating Olfactory Neurons and Evokes Widespread Changes
in Neural Activity.” Proceedings of the National Academy of Sciences, vol.
112, no. 27, National Academy of Sciences, 2015, pp. E3525–34, doi:10.1073/pnas.1423808112.
short: L.A. Fenk, M. de Bono, Proceedings of the National Academy of Sciences 112
(2015) E3525–E3534.
date_created: 2019-03-19T14:15:50Z
date_published: 2015-07-07T00:00:00Z
date_updated: 2021-01-12T08:06:12Z
day: '07'
ddc:
- '570'
doi: 10.1073/pnas.1423808112
extern: '1'
external_id:
pmid:
- '26100886'
file:
- access_level: open_access
checksum: 3d2da5af8d72467e382a565abc2e003d
content_type: application/pdf
creator: kschuh
date_created: 2019-03-19T14:21:07Z
date_updated: 2020-07-14T12:47:20Z
file_id: '6119'
file_name: 2015_PNAS_Fenk.pdf
file_size: 2822681
relation: main_file
file_date_updated: 2020-07-14T12:47:20Z
has_accepted_license: '1'
intvolume: ' 112'
issue: '27'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: E3525-E3534
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
issn:
- 0027-8424
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
status: public
title: Environmental CO2 inhibits Caenorhabditis elegans egg-laying by modulating
olfactory neurons and evokes widespread changes in neural activity
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2015'
...
---
_id: '6120'
abstract:
- lang: eng
text: Brains organize behavior and physiology to optimize the response to threats
or opportunities. We dissect how 21% O2, an indicator of surface exposure, reprograms
C. elegans' global state, inducing sustained locomotory arousal and altering expression
of neuropeptides, metabolic enzymes, and other non-neural genes. The URX O2-sensing
neurons drive arousal at 21% O2 by tonically activating the RMG interneurons.
Stimulating RMG is sufficient to switch behavioral state. Ablating the ASH, ADL,
or ASK sensory neurons connected to RMG by gap junctions does not disrupt arousal.
However, disrupting cation currents in these neurons curtails RMG neurosecretion
and arousal. RMG signals high O2 by peptidergic secretion. Neuropeptide reporters
reveal neural circuit state, as neurosecretion stimulates neuropeptide expression.
Neural imaging in unrestrained animals shows that URX and RMG encode O2 concentration
rather than behavior, while the activity of downstream interneurons such as AVB
and AIY reflect both O2 levels and the behavior being executed.
article_number: e04241
author:
- first_name: Patrick
full_name: Laurent, Patrick
last_name: Laurent
- first_name: Zoltan
full_name: Soltesz, Zoltan
last_name: Soltesz
- first_name: Geoffrey M
full_name: Nelson, Geoffrey M
last_name: Nelson
- first_name: Changchun
full_name: Chen, Changchun
last_name: Chen
- first_name: Fausto
full_name: Arellano-Carbajal, Fausto
last_name: Arellano-Carbajal
- first_name: Emmanuel
full_name: Levy, Emmanuel
last_name: Levy
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Laurent P, Soltesz Z, Nelson GM, et al. Decoding a neural circuit controlling
global animal state in C. elegans. eLife. 2015;4. doi:10.7554/elife.04241
apa: Laurent, P., Soltesz, Z., Nelson, G. M., Chen, C., Arellano-Carbajal, F., Levy,
E., & de Bono, M. (2015). Decoding a neural circuit controlling global animal
state in C. elegans. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.04241
chicago: Laurent, Patrick, Zoltan Soltesz, Geoffrey M Nelson, Changchun Chen, Fausto
Arellano-Carbajal, Emmanuel Levy, and Mario de Bono. “Decoding a Neural Circuit
Controlling Global Animal State in C. Elegans.” ELife. eLife Sciences Publications,
2015. https://doi.org/10.7554/elife.04241.
ieee: P. Laurent et al., “Decoding a neural circuit controlling global animal
state in C. elegans,” eLife, vol. 4. eLife Sciences Publications, 2015.
ista: Laurent P, Soltesz Z, Nelson GM, Chen C, Arellano-Carbajal F, Levy E, de Bono
M. 2015. Decoding a neural circuit controlling global animal state in C. elegans.
eLife. 4, e04241.
mla: Laurent, Patrick, et al. “Decoding a Neural Circuit Controlling Global Animal
State in C. Elegans.” ELife, vol. 4, e04241, eLife Sciences Publications,
2015, doi:10.7554/elife.04241.
short: P. Laurent, Z. Soltesz, G.M. Nelson, C. Chen, F. Arellano-Carbajal, E. Levy,
M. de Bono, ELife 4 (2015).
date_created: 2019-03-19T14:23:51Z
date_published: 2015-03-11T00:00:00Z
date_updated: 2021-01-12T08:06:13Z
day: '11'
ddc:
- '570'
doi: 10.7554/elife.04241
extern: '1'
external_id:
pmid:
- '25760081'
file:
- access_level: open_access
checksum: cf641b7a363aecd0a101755d23dee7e0
content_type: application/pdf
creator: kschuh
date_created: 2019-03-19T14:29:43Z
date_updated: 2020-07-14T12:47:20Z
file_id: '6121'
file_name: 2015_elife_Laurent.pdf
file_size: 6723528
relation: main_file
file_date_updated: 2020-07-14T12:47:20Z
has_accepted_license: '1'
intvolume: ' 4'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
status: public
title: Decoding a neural circuit controlling global animal state in C. elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...
---
_id: '1637'
abstract:
- lang: eng
text: An instance of the Valued Constraint Satisfaction Problem (VCSP) is given
by a finite set of variables, a finite domain of labels, and a sum of functions,
each function depending on a subset of the variables. Each function can take finite
values specifying costs of assignments of labels to its variables or the infinite
value, which indicates an infeasible assignment. The goal is to find an assignment
of labels to the variables that minimizes the sum. We study, assuming that P ≠
NP, how the complexity of this very general problem depends on the set of functions
allowed in the instances, the so-called constraint language. The case when all
allowed functions take values in {0, ∞} corresponds to ordinary CSPs, where one
deals only with the feasibility issue and there is no optimization. This case
is the subject of the Algebraic CSP Dichotomy Conjecture predicting for which
constraint languages CSPs are tractable (i.e. solvable in polynomial time) and
for which NP-hard. The case when all allowed functions take only finite values
corresponds to finite-valued CSP, where the feasibility aspect is trivial and
one deals only with the optimization issue. The complexity of finite-valued CSPs
was fully classified by Thapper and Zivny. An algebraic necessary condition for
tractability of a general-valued CSP with a fixed constraint language was recently
given by Kozik and Ochremiak. As our main result, we prove that if a constraint
language satisfies this algebraic necessary condition, and the feasibility CSP
(i.e. the problem of deciding whether a given instance has a feasible solution)
corresponding to the VCSP with this language is tractable, then the VCSP is tractable.
The algorithm is a simple combination of the assumed algorithm for the feasibility
CSP and the standard LP relaxation. As a corollary, we obtain that a dichotomy
for ordinary CSPs would imply a dichotomy for general-valued CSPs.
alternative_title:
- 56th Annual Symposium on Foundations of Computer Science
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: Andrei
full_name: Krokhin, Andrei
last_name: Krokhin
- first_name: Michal
full_name: Rolinek, Michal
id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
last_name: Rolinek
citation:
ama: 'Kolmogorov V, Krokhin A, Rolinek M. The complexity of general-valued CSPs.
In: IEEE; 2015:1246-1258. doi:10.1109/FOCS.2015.80'
apa: 'Kolmogorov, V., Krokhin, A., & Rolinek, M. (2015). The complexity of general-valued
CSPs (pp. 1246–1258). Presented at the FOCS: Foundations of Computer Science,
Berkeley, CA, United States: IEEE. https://doi.org/10.1109/FOCS.2015.80'
chicago: Kolmogorov, Vladimir, Andrei Krokhin, and Michal Rolinek. “The Complexity
of General-Valued CSPs,” 1246–58. IEEE, 2015. https://doi.org/10.1109/FOCS.2015.80.
ieee: 'V. Kolmogorov, A. Krokhin, and M. Rolinek, “The complexity of general-valued
CSPs,” presented at the FOCS: Foundations of Computer Science, Berkeley, CA, United
States, 2015, pp. 1246–1258.'
ista: 'Kolmogorov V, Krokhin A, Rolinek M. 2015. The complexity of general-valued
CSPs. FOCS: Foundations of Computer Science, 56th Annual Symposium on Foundations
of Computer Science, , 1246–1258.'
mla: Kolmogorov, Vladimir, et al. The Complexity of General-Valued CSPs.
IEEE, 2015, pp. 1246–58, doi:10.1109/FOCS.2015.80.
short: V. Kolmogorov, A. Krokhin, M. Rolinek, in:, IEEE, 2015, pp. 1246–1258.
conference:
end_date: 2015-10-20
location: Berkeley, CA, United States
name: 'FOCS: Foundations of Computer Science'
start_date: 2015-10-18
date_created: 2018-12-11T11:53:10Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2023-02-23T12:44:26Z
day: '01'
department:
- _id: VlKo
doi: 10.1109/FOCS.2015.80
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1502.07327
month: '12'
oa: 1
oa_version: Preprint
page: 1246 - 1258
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication_status: published
publisher: IEEE
publist_id: '5518'
quality_controlled: '1'
related_material:
record:
- id: '644'
relation: other
status: public
scopus_import: 1
status: public
title: The complexity of general-valued CSPs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '6507'
abstract:
- lang: eng
text: The osteoclast-associated receptor (OSCAR) is a collagen-binding immune receptor
with important roles in dendritic cell maturation and activation of inflammatory
monocytes as well as in osteoclastogenesis. The crystal structure of the OSCAR
ectodomain is presented, both free and in complex with a consensus triple-helical
peptide (THP). The structures revealed a collagen-binding site in each immunoglobulin-like
domain (D1 and D2). The THP binds near a predicted collagen-binding groove in
D1, but a more extensive interaction with D2 is facilitated by the unusually wide
D1-D2 interdomain angle in OSCAR. Direct binding assays, combined with site-directed
mutagenesis, confirm that the primary collagen-binding site in OSCAR resides in
D2, in marked contrast to the related collagen receptors, glycoprotein VI (GPVI)
and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). Monomeric OSCAR
D1D2 binds to the consensus THP with a KD of 28 µM measured in solution, but shows
a higher affinity (KD 1.5 μM) when binding to a solid-phase THP, most likely due
to an avidity effect. These data suggest a 2-stage model for the interaction of
OSCAR with a collagen fibril, with transient, low-affinity interactions initiated
by the membrane-distal D1, followed by firm adhesion to the primary binding site
in D2.
author:
- first_name: Long
full_name: Zhou, Long
id: 3E751364-F248-11E8-B48F-1D18A9856A87
last_name: Zhou
orcid: 0000-0002-1864-8951
- first_name: J. M.
full_name: Hinerman, J. M.
last_name: Hinerman
- first_name: M.
full_name: Blaszczyk, M.
last_name: Blaszczyk
- first_name: J. L. C.
full_name: Miller, J. L. C.
last_name: Miller
- first_name: D. G.
full_name: Conrady, D. G.
last_name: Conrady
- first_name: A. D.
full_name: Barrow, A. D.
last_name: Barrow
- first_name: D. Y.
full_name: Chirgadze, D. Y.
last_name: Chirgadze
- first_name: D.
full_name: Bihan, D.
last_name: Bihan
- first_name: R. W.
full_name: Farndale, R. W.
last_name: Farndale
- first_name: A. B.
full_name: Herr, A. B.
last_name: Herr
citation:
ama: Zhou L, Hinerman JM, Blaszczyk M, et al. Structural basis for collagen recognition
by the immune receptor OSCAR. Blood. 2015;127(5):529-537. doi:10.1182/blood-2015-08-667055
apa: Zhou, L., Hinerman, J. M., Blaszczyk, M., Miller, J. L. C., Conrady, D. G.,
Barrow, A. D., … Herr, A. B. (2015). Structural basis for collagen recognition
by the immune receptor OSCAR. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2015-08-667055
chicago: Zhou, Long, J. M. Hinerman, M. Blaszczyk, J. L. C. Miller, D. G. Conrady,
A. D. Barrow, D. Y. Chirgadze, D. Bihan, R. W. Farndale, and A. B. Herr. “Structural
Basis for Collagen Recognition by the Immune Receptor OSCAR.” Blood. American
Society of Hematology, 2015. https://doi.org/10.1182/blood-2015-08-667055.
ieee: L. Zhou et al., “Structural basis for collagen recognition by the immune
receptor OSCAR,” Blood, vol. 127, no. 5. American Society of Hematology,
pp. 529–537, 2015.
ista: Zhou L, Hinerman JM, Blaszczyk M, Miller JLC, Conrady DG, Barrow AD, Chirgadze
DY, Bihan D, Farndale RW, Herr AB. 2015. Structural basis for collagen recognition
by the immune receptor OSCAR. Blood. 127(5), 529–537.
mla: Zhou, Long, et al. “Structural Basis for Collagen Recognition by the Immune
Receptor OSCAR.” Blood, vol. 127, no. 5, American Society of Hematology,
2015, pp. 529–37, doi:10.1182/blood-2015-08-667055.
short: L. Zhou, J.M. Hinerman, M. Blaszczyk, J.L.C. Miller, D.G. Conrady, A.D. Barrow,
D.Y. Chirgadze, D. Bihan, R.W. Farndale, A.B. Herr, Blood 127 (2015) 529–537.
date_created: 2019-05-31T09:38:50Z
date_published: 2015-11-02T00:00:00Z
date_updated: 2021-01-12T08:07:47Z
day: '02'
doi: 10.1182/blood-2015-08-667055
extern: '1'
external_id:
pmid:
- '26552697'
intvolume: ' 127'
issue: '5'
language:
- iso: eng
month: '11'
oa_version: None
page: 529-537
pmid: 1
publication: Blood
publication_identifier:
issn:
- 0006-4971
- 1528-0020
publication_status: published
publisher: American Society of Hematology
quality_controlled: '1'
status: public
title: Structural basis for collagen recognition by the immune receptor OSCAR
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 127
year: '2015'
...