---
_id: '8013'
article_number: e1007049
article_processing_charge: No
article_type: original
author:
- first_name: Christopher B.
full_name: Currin, Christopher B.
last_name: Currin
- first_name: Phumlani N.
full_name: Khoza, Phumlani N.
last_name: Khoza
- first_name: Alexander D.
full_name: Antrobus, Alexander D.
last_name: Antrobus
- first_name: Peter E.
full_name: Latham, Peter E.
last_name: Latham
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Joseph V.
full_name: Raimondo, Joseph V.
last_name: Raimondo
citation:
ama: 'Currin CB, Khoza PN, Antrobus AD, Latham PE, Vogels TP, Raimondo JV. Think:
Theory for Africa. PLOS Computational Biology. 2019;15(7). doi:10.1371/journal.pcbi.1007049'
apa: 'Currin, C. B., Khoza, P. N., Antrobus, A. D., Latham, P. E., Vogels, T. P.,
& Raimondo, J. V. (2019). Think: Theory for Africa. PLOS Computational
Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1007049'
chicago: 'Currin, Christopher B., Phumlani N. Khoza, Alexander D. Antrobus, Peter
E. Latham, Tim P Vogels, and Joseph V. Raimondo. “Think: Theory for Africa.” PLOS
Computational Biology. Public Library of Science, 2019. https://doi.org/10.1371/journal.pcbi.1007049.'
ieee: 'C. B. Currin, P. N. Khoza, A. D. Antrobus, P. E. Latham, T. P. Vogels, and
J. V. Raimondo, “Think: Theory for Africa,” PLOS Computational Biology,
vol. 15, no. 7. Public Library of Science, 2019.'
ista: 'Currin CB, Khoza PN, Antrobus AD, Latham PE, Vogels TP, Raimondo JV. 2019.
Think: Theory for Africa. PLOS Computational Biology. 15(7), e1007049.'
mla: 'Currin, Christopher B., et al. “Think: Theory for Africa.” PLOS Computational
Biology, vol. 15, no. 7, e1007049, Public Library of Science, 2019, doi:10.1371/journal.pcbi.1007049.'
short: C.B. Currin, P.N. Khoza, A.D. Antrobus, P.E. Latham, T.P. Vogels, J.V. Raimondo,
PLOS Computational Biology 15 (2019).
date_created: 2020-06-25T12:50:39Z
date_published: 2019-07-11T00:00:00Z
date_updated: 2021-01-12T08:16:31Z
day: '11'
ddc:
- '570'
doi: 10.1371/journal.pcbi.1007049
extern: '1'
external_id:
pmid:
- '31295253'
file:
- access_level: open_access
checksum: 723bdfb6ee5c747cbbb32baf01d17fad
content_type: application/pdf
creator: cziletti
date_created: 2020-07-02T12:22:57Z
date_updated: 2020-07-14T12:48:08Z
file_id: '8079'
file_name: 2019_PlosCompBio_Currin.pdf
file_size: 773969
relation: main_file
file_date_updated: 2020-07-14T12:48:08Z
has_accepted_license: '1'
intvolume: ' 15'
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Computational Biology
publication_identifier:
issn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
status: public
title: 'Think: Theory for Africa'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 15
year: '2019'
...
---
_id: '8014'
abstract:
- lang: eng
text: 'Working memory, the ability to keep recently accessed information available
for immediate manipulation, has been proposed to rely on two mechanisms that appear
difficult to reconcile: self-sustained neural firing, or the opposite—activity-silent
synaptic traces. Here we review and contrast models of these two mechanisms, and
then show that both phenomena can co-exist within a unified system in which neurons
hold information in both activity and synapses. Rapid plasticity in flexibly-coding
neurons allows features to be bound together into objects, with an important emergent
property being the focus of attention. One memory item is held by persistent activity
in an attended or “focused” state, and is thus remembered better than other items.
Other, previously attended items can remain in memory but in the background, encoded
in activity-silent synaptic traces. This dual functional architecture provides
a unified common mechanism accounting for a diversity of perplexing attention
and memory effects that have been hitherto difficult to explain in a single theoretical
framework.'
article_processing_charge: No
article_type: original
author:
- first_name: Sanjay G.
full_name: Manohar, Sanjay G.
last_name: Manohar
- first_name: Nahid
full_name: Zokaei, Nahid
last_name: Zokaei
- first_name: Sean J.
full_name: Fallon, Sean J.
last_name: Fallon
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Masud
full_name: Husain, Masud
last_name: Husain
citation:
ama: Manohar SG, Zokaei N, Fallon SJ, Vogels TP, Husain M. Neural mechanisms of
attending to items in working memory. Neuroscience and Biobehavioral Reviews.
2019;101:1-12. doi:10.1016/j.neubiorev.2019.03.017
apa: Manohar, S. G., Zokaei, N., Fallon, S. J., Vogels, T. P., & Husain, M.
(2019). Neural mechanisms of attending to items in working memory. Neuroscience
and Biobehavioral Reviews. Elsevier . https://doi.org/10.1016/j.neubiorev.2019.03.017
chicago: Manohar, Sanjay G., Nahid Zokaei, Sean J. Fallon, Tim P Vogels, and Masud
Husain. “Neural Mechanisms of Attending to Items in Working Memory.” Neuroscience
and Biobehavioral Reviews. Elsevier , 2019. https://doi.org/10.1016/j.neubiorev.2019.03.017.
ieee: S. G. Manohar, N. Zokaei, S. J. Fallon, T. P. Vogels, and M. Husain, “Neural
mechanisms of attending to items in working memory,” Neuroscience and Biobehavioral
Reviews, vol. 101. Elsevier , pp. 1–12, 2019.
ista: Manohar SG, Zokaei N, Fallon SJ, Vogels TP, Husain M. 2019. Neural mechanisms
of attending to items in working memory. Neuroscience and Biobehavioral Reviews.
101, 1–12.
mla: Manohar, Sanjay G., et al. “Neural Mechanisms of Attending to Items in Working
Memory.” Neuroscience and Biobehavioral Reviews, vol. 101, Elsevier , 2019,
pp. 1–12, doi:10.1016/j.neubiorev.2019.03.017.
short: S.G. Manohar, N. Zokaei, S.J. Fallon, T.P. Vogels, M. Husain, Neuroscience
and Biobehavioral Reviews 101 (2019) 1–12.
date_created: 2020-06-25T12:52:13Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2021-01-12T08:16:31Z
day: '01'
ddc:
- '570'
doi: 10.1016/j.neubiorev.2019.03.017
extern: '1'
external_id:
pmid:
- '30922977'
file:
- access_level: open_access
checksum: 7b972e3d6f7bb3122c8c5648f44e60ca
content_type: application/pdf
creator: cziletti
date_created: 2020-07-02T13:17:52Z
date_updated: 2020-07-14T12:48:08Z
file_id: '8080'
file_name: 2019_NeurosBiobehavRev_Manohar.pdf
file_size: 1754418
relation: main_file
file_date_updated: 2020-07-14T12:48:08Z
has_accepted_license: '1'
intvolume: ' 101'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://doi.org/10.1101/233007 '
month: '06'
oa: 1
oa_version: Published Version
page: 1-12
pmid: 1
publication: Neuroscience and Biobehavioral Reviews
publication_identifier:
issn:
- 0149-7634
publication_status: published
publisher: 'Elsevier '
quality_controlled: '1'
status: public
title: Neural mechanisms of attending to items in working memory
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 101
year: '2019'
...
---
_id: '8175'
abstract:
- lang: eng
text: We study edge asymptotics of poissonized Plancherel-type measures on skew
Young diagrams (integer partitions). These measures can be seen as generalizations
of those studied by Baik--Deift--Johansson and Baik--Rains in resolving Ulam's
problem on longest increasing subsequences of random permutations and the last
passage percolation (corner growth) discrete versions thereof. Moreover they interpolate
between said measures and the uniform measure on partitions. In the new KPZ-like
1/3 exponent edge scaling limit with logarithmic corrections, we find new probability
distributions generalizing the classical Tracy--Widom GUE, GOE and GSE distributions
from the theory of random matrices.
acknowledgement: "D.B. is especially grateful to Patrik Ferrari for suggesting simplifications
in Section 3 and\r\nto Alessandra Occelli for suggesting the name for the models
of Section 2.\r\n"
article_number: '34'
article_processing_charge: No
author:
- first_name: Dan
full_name: Betea, Dan
last_name: Betea
- first_name: Jérémie
full_name: Bouttier, Jérémie
last_name: Bouttier
- first_name: Peter
full_name: Nejjar, Peter
id: 4BF426E2-F248-11E8-B48F-1D18A9856A87
last_name: Nejjar
- first_name: Mirjana
full_name: Vuletíc, Mirjana
last_name: Vuletíc
citation:
ama: 'Betea D, Bouttier J, Nejjar P, Vuletíc M. New edge asymptotics of skew Young
diagrams via free boundaries. In: Proceedings on the 31st International Conference
on Formal Power Series and Algebraic Combinatorics. Formal Power Series and
Algebraic Combinatorics; 2019.'
apa: 'Betea, D., Bouttier, J., Nejjar, P., & Vuletíc, M. (2019). New edge asymptotics
of skew Young diagrams via free boundaries. In Proceedings on the 31st International
Conference on Formal Power Series and Algebraic Combinatorics. Ljubljana,
Slovenia: Formal Power Series and Algebraic Combinatorics.'
chicago: Betea, Dan, Jérémie Bouttier, Peter Nejjar, and Mirjana Vuletíc. “New Edge
Asymptotics of Skew Young Diagrams via Free Boundaries.” In Proceedings on
the 31st International Conference on Formal Power Series and Algebraic Combinatorics.
Formal Power Series and Algebraic Combinatorics, 2019.
ieee: D. Betea, J. Bouttier, P. Nejjar, and M. Vuletíc, “New edge asymptotics of
skew Young diagrams via free boundaries,” in Proceedings on the 31st International
Conference on Formal Power Series and Algebraic Combinatorics, Ljubljana,
Slovenia, 2019.
ista: 'Betea D, Bouttier J, Nejjar P, Vuletíc M. 2019. New edge asymptotics of skew
Young diagrams via free boundaries. Proceedings on the 31st International Conference
on Formal Power Series and Algebraic Combinatorics. FPSAC: International Conference
on Formal Power Series and Algebraic Combinatorics, 34.'
mla: Betea, Dan, et al. “New Edge Asymptotics of Skew Young Diagrams via Free Boundaries.”
Proceedings on the 31st International Conference on Formal Power Series and
Algebraic Combinatorics, 34, Formal Power Series and Algebraic Combinatorics,
2019.
short: D. Betea, J. Bouttier, P. Nejjar, M. Vuletíc, in:, Proceedings on the 31st
International Conference on Formal Power Series and Algebraic Combinatorics, Formal
Power Series and Algebraic Combinatorics, 2019.
conference:
end_date: 2019-07-05
location: Ljubljana, Slovenia
name: 'FPSAC: International Conference on Formal Power Series and Algebraic Combinatorics'
start_date: 2019-07-01
date_created: 2020-07-26T22:01:04Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2021-01-12T08:17:18Z
day: '01'
department:
- _id: LaEr
ec_funded: 1
external_id:
arxiv:
- '1902.08750'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.08750
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
publication: Proceedings on the 31st International Conference on Formal Power Series
and Algebraic Combinatorics
publication_status: published
publisher: Formal Power Series and Algebraic Combinatorics
quality_controlled: '1'
scopus_import: '1'
status: public
title: New edge asymptotics of skew Young diagrams via free boundaries
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '8228'
abstract:
- lang: eng
text: "Background: Atopics have a lower risk for malignancies, and IgE targeted
to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or
adaptive immune surveillance can confer protection against tumors remains unclear.\r\nObjective:
We aimed to investigate the effects of active and passive immunotherapy to the
tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor
expression affecting the levels of expressed IgE.\r\nMethods: We compared the
levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b,
IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic
domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1
mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated
serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2
mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle
control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated
with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy).\r\nResults:
Overall, among the three strains of mice, HER-2 vaccination induced significantly
higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while low-IgE ΔM1M2
mice had higher IgG2a levels. HER-2 vaccination and passive immunotherapy prolonged
the survival in tumor-grafted WT and low-IgE ΔM1M2 strains compared with treatment
controls; active vaccination provided the highest benefit. Notably, untreated
high-IgE KN1 mice displayed the longest survival of all strains, which could not
be further extended by active or passive immunotherapy.\r\nConclusion: Active
and passive immunotherapies prolong survival in wild type and low-IgE ΔM1M2 mice
engrafted with mammary tumors. High-IgE KN1 mice have an innate survival benefit
following tumor challenge."
article_number: '100044'
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Singer, Josef
last_name: Singer
orcid: 0000-0002-8701-2412
- first_name: Gertrude
full_name: Achatz-Straussberger, Gertrude
last_name: Achatz-Straussberger
- first_name: Anna
full_name: Bentley-Lukschal, Anna
last_name: Bentley-Lukschal
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Gernot
full_name: Achatz, Gernot
last_name: Achatz
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
citation:
ama: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, et al. AllergoOncology:
High innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. 2019;12(7). doi:10.1016/j.waojou.2019.100044'
apa: 'Singer, J., Achatz-Straussberger, G., Bentley-Lukschal, A., Singer, J., Achatz,
G., Karagiannis, S. N., & Jensen-Jarolim, E. (2019). AllergoOncology: High
innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. Elsevier. https://doi.org/10.1016/j.waojou.2019.100044'
chicago: 'Singer, Josef, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit
Singer, Gernot Achatz, Sophia N. Karagiannis, and Erika Jensen-Jarolim. “AllergoOncology:
High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.”
World Allergy Organization Journal. Elsevier, 2019. https://doi.org/10.1016/j.waojou.2019.100044.'
ieee: 'J. Singer et al., “AllergoOncology: High innate IgE levels are decisive
for the survival of cancer-bearing mice,” World Allergy Organization Journal,
vol. 12, no. 7. Elsevier, 2019.'
ista: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, Singer J, Achatz G,
Karagiannis SN, Jensen-Jarolim E. 2019. AllergoOncology: High innate IgE levels
are decisive for the survival of cancer-bearing mice. World Allergy Organization
Journal. 12(7), 100044.'
mla: 'Singer, Josef, et al. “AllergoOncology: High Innate IgE Levels Are Decisive
for the Survival of Cancer-Bearing Mice.” World Allergy Organization Journal,
vol. 12, no. 7, 100044, Elsevier, 2019, doi:10.1016/j.waojou.2019.100044.'
short: J. Singer, G. Achatz-Straussberger, A. Bentley-Lukschal, J. Singer, G. Achatz,
S.N. Karagiannis, E. Jensen-Jarolim, World Allergy Organization Journal 12 (2019).
date_created: 2020-08-10T11:50:54Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '29'
doi: 10.1016/j.waojou.2019.100044
extern: '1'
intvolume: ' 12'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.waojou.2019.100044
month: '07'
oa: 1
oa_version: Published Version
publication: World Allergy Organization Journal
publication_identifier:
issn:
- 1939-4551
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing
mice'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...
---
_id: '8229'
abstract:
- lang: eng
text: Food proteins may get nitrated by various exogenous or endogenous mechanisms.
As individuals might get recurrently exposed to nitrated proteins via daily diet,
we aimed to investigate the effect of repeatedly ingested nitrated food proteins
on the subsequent immune response in non-allergic and allergic mice using the
milk allergen beta-lactoglobulin (BLG) as model food protein in a mouse model.
Evaluating the presence of nitrated proteins in food, we could detect 3-nitrotyrosine
(3-NT) in extracts of different foods and in stomach content extracts of non-allergic
mice under physiological conditions. Chemically nitrated BLG (BLGn) exhibited
enhanced susceptibility to degradation in simulated gastric fluid experiments
compared to untreated BLG (BLGu). Gavage of BLGn to non-allergic animals increased
interferon-γ and interleukin-10 release of stimulated spleen cells and led to
the formation of BLG-specific serum IgA. Allergic mice receiving three oral gavages
of BLGn had higher levels of mouse mast cell protease-1 (mMCP-1) compared to allergic
mice receiving BLGu. Regardless of the preceding immune status, non-allergic or
allergic, repeatedly ingested nitrated food proteins seem to considerably influence
the subsequent immune response.
article_number: '2463'
article_processing_charge: No
article_type: original
author:
- first_name: Anna S.
full_name: Ondracek, Anna S.
last_name: Ondracek
orcid: 0000-0001-7625-3651
- first_name: Denise
full_name: Heiden, Denise
last_name: Heiden
- first_name: Gertie J.
full_name: Oostingh, Gertie J.
last_name: Oostingh
- first_name: Elisabeth
full_name: Fuerst, Elisabeth
last_name: Fuerst
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Cornelia
full_name: Bergmayr, Cornelia
last_name: Bergmayr
- first_name: Johanna
full_name: Rohrhofer, Johanna
last_name: Rohrhofer
orcid: 0000-0002-2783-2099
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
orcid: 0000-0003-4019-5765
- first_name: Albert
full_name: Duschl, Albert
last_name: Duschl
orcid: 0000-0002-7034-9860
- first_name: Eva
full_name: Untersmayr, Eva
last_name: Untersmayr
orcid: 0000-0002-1963-499X
citation:
ama: Ondracek AS, Heiden D, Oostingh GJ, et al. Immune effects of the nitrated food
allergen beta-lactoglobulin in an experimental food allergy model. Nutrients.
2019;11(10). doi:10.3390/nu11102463
apa: Ondracek, A. S., Heiden, D., Oostingh, G. J., Fuerst, E., Singer, J., Bergmayr,
C., … Untersmayr, E. (2019). Immune effects of the nitrated food allergen beta-lactoglobulin
in an experimental food allergy model. Nutrients. MDPI. https://doi.org/10.3390/nu11102463
chicago: Ondracek, Anna S., Denise Heiden, Gertie J. Oostingh, Elisabeth Fuerst,
Judit Singer, Cornelia Bergmayr, Johanna Rohrhofer, Erika Jensen-Jarolim, Albert
Duschl, and Eva Untersmayr. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
in an Experimental Food Allergy Model.” Nutrients. MDPI, 2019. https://doi.org/10.3390/nu11102463.
ieee: A. S. Ondracek et al., “Immune effects of the nitrated food allergen
beta-lactoglobulin in an experimental food allergy model,” Nutrients, vol.
11, no. 10. MDPI, 2019.
ista: Ondracek AS, Heiden D, Oostingh GJ, Fuerst E, Singer J, Bergmayr C, Rohrhofer
J, Jensen-Jarolim E, Duschl A, Untersmayr E. 2019. Immune effects of the nitrated
food allergen beta-lactoglobulin in an experimental food allergy model. Nutrients.
11(10), 2463.
mla: Ondracek, Anna S., et al. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
in an Experimental Food Allergy Model.” Nutrients, vol. 11, no. 10, 2463,
MDPI, 2019, doi:10.3390/nu11102463.
short: A.S. Ondracek, D. Heiden, G.J. Oostingh, E. Fuerst, J. Singer, C. Bergmayr,
J. Rohrhofer, E. Jensen-Jarolim, A. Duschl, E. Untersmayr, Nutrients 11 (2019).
date_created: 2020-08-10T11:51:04Z
date_published: 2019-10-15T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '15'
doi: 10.3390/nu11102463
extern: '1'
intvolume: ' 11'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3390/nu11102463
month: '10'
oa: 1
oa_version: Published Version
publication: Nutrients
publication_identifier:
issn:
- 2072-6643
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental
food allergy model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...
---
_id: '8227'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Kristina M.
full_name: Ilieva, Kristina M.
last_name: Ilieva
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Heather J.
full_name: Bax, Heather J.
last_name: Bax
- first_name: Silvia
full_name: Crescioli, Silvia
last_name: Crescioli
- first_name: Laura
full_name: Montero‐Morales, Laura
last_name: Montero‐Morales
- first_name: Silvia
full_name: Mele, Silvia
last_name: Mele
- first_name: Heng Sheng
full_name: Sow, Heng Sheng
last_name: Sow
- first_name: Chara
full_name: Stavraka, Chara
last_name: Stavraka
- first_name: Debra H.
full_name: Josephs, Debra H.
last_name: Josephs
- first_name: James F.
full_name: Spicer, James F.
last_name: Spicer
- first_name: Herta
full_name: Steinkellner, Herta
last_name: Steinkellner
orcid: 0000-0003-4823-1505
- first_name: Erika
full_name: Jensen‐Jarolim, Erika
last_name: Jensen‐Jarolim
orcid: 0000-0003-4019-5765
- first_name: Andrew N. J.
full_name: Tutt, Andrew N. J.
last_name: Tutt
orcid: 0000-0001-8715-2901
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
orcid: 0000-0002-4100-7810
citation:
ama: 'Ilieva KM, Singer J, Bax HJ, et al. AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody. Allergy. 2019;74(10):1985-1989.
doi:10.1111/all.13818'
apa: 'Ilieva, K. M., Singer, J., Bax, H. J., Crescioli, S., Montero‐Morales, L.,
Mele, S., … Karagiannis, S. N. (2019). AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody. Allergy. Wiley.
https://doi.org/10.1111/all.13818'
chicago: 'Ilieva, Kristina M., Judit Singer, Heather J. Bax, Silvia Crescioli, Laura
Montero‐Morales, Silvia Mele, Heng Sheng Sow, et al. “AllergoOncology: Expression
Platform Development and Functional Profiling of an Anti‐HER2 IgE Antibody.” Allergy.
Wiley, 2019. https://doi.org/10.1111/all.13818.'
ieee: 'K. M. Ilieva et al., “AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody,” Allergy, vol. 74,
no. 10. Wiley, pp. 1985–1989, 2019.'
ista: 'Ilieva KM, Singer J, Bax HJ, Crescioli S, Montero‐Morales L, Mele S, Sow
HS, Stavraka C, Josephs DH, Spicer JF, Steinkellner H, Jensen‐Jarolim E, Tutt
ANJ, Karagiannis SN. 2019. AllergoOncology: Expression platform development and
functional profiling of an anti‐HER2 IgE antibody. Allergy. 74(10), 1985–1989.'
mla: 'Ilieva, Kristina M., et al. “AllergoOncology: Expression Platform Development
and Functional Profiling of an Anti‐HER2 IgE Antibody.” Allergy, vol. 74,
no. 10, Wiley, 2019, pp. 1985–89, doi:10.1111/all.13818.'
short: K.M. Ilieva, J. Singer, H.J. Bax, S. Crescioli, L. Montero‐Morales, S. Mele,
H.S. Sow, C. Stavraka, D.H. Josephs, J.F. Spicer, H. Steinkellner, E. Jensen‐Jarolim,
A.N.J. Tutt, S.N. Karagiannis, Allergy 74 (2019) 1985–1989.
date_created: 2020-08-10T11:50:42Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2021-01-12T08:17:35Z
day: '01'
doi: 10.1111/all.13818
extern: '1'
intvolume: ' 74'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/all.13818
month: '10'
oa: 1
oa_version: Published Version
page: 1985-1989
publication: Allergy
publication_identifier:
issn:
- 0105-4538
- 1398-9995
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'AllergoOncology: Expression platform development and functional profiling
of an anti‐HER2 IgE antibody'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 74
year: '2019'
...
---
_id: '8263'
abstract:
- lang: eng
text: "Background: The genus Streptococcus comprises pathogens that strongly influence
the health of humans and animals. Genome sequencing of multiple Streptococcus
strains demonstrated high variability in gene content and order even in closely
related strains of the same species and created a newly emerged object for genomic
analysis, the pan-genome. Here we analysed the genome evolution of 25 strains
of Streptococcus suis, 50 strains of Streptococcus pyogenes and 28 strains of
Streptococcus pneumoniae.\r\n\r\nResults: Fractions of the pan-genome, unique,
periphery, and universal genes differ in size, functional composition, the level
of nucleotide substitutions, and predisposition to horizontal gene transfer and
genomic rearrangements. The density of substitutions in intergenic regions appears
to be correlated with selection acting on adjacent genes, implying that more conserved
genes tend to have more conserved regulatory regions.\r\nThe total pan-genome
of the genus is open, but only due to strain-specific genes, whereas other pan-genome
fractions reach saturation. We have identified the set of genes with phylogenies
inconsistent with species and non-conserved location in the chromosome; these
genes are rare in at least one species and have likely experienced recent horizontal
transfer between species. The strain-specific fraction is enriched with mobile
elements and hypothetical proteins, but also contains a number of candidate virulence-related
genes, so it may have a strong impact on adaptability and pathogenicity.\r\nMapping
the rearrangements to the phylogenetic tree revealed large parallel inversions
in all species. A parallel inversion of length 15 kB with breakpoints formed by
genes encoding surface antigen proteins PhtD and PhtB in S. pneumoniae leads to
replacement of gene fragments that likely indicates the action of an antigen variation
mechanism.\r\n\r\nConclusions: Members of genus Streptococcus have a highly dynamic,
open pan-genome, that potentially confers them with the ability to adapt to changing
environmental conditions, i.e. antibiotic resistance or transmission between different
hosts. Hence, integrated analysis of all aspects of genome evolution is important
for the identification of potential pathogens and design of drugs and vaccines."
article_number: '83'
article_processing_charge: No
article_type: original
author:
- first_name: Pavel V.
full_name: Shelyakin, Pavel V.
last_name: Shelyakin
orcid: 0000-0003-0120-9319
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Anna A.
full_name: Karan, Anna A.
last_name: Karan
- first_name: Mikhail S.
full_name: Gelfand, Mikhail S.
last_name: Gelfand
citation:
ama: 'Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. Micro-evolution of three
Streptococcus species: Selection, antigenic variation, and horizontal gene inflow.
BMC Evolutionary Biology. 2019;19. doi:10.1186/s12862-019-1403-6'
apa: 'Shelyakin, P. V., Bochkareva, O., Karan, A. A., & Gelfand, M. S. (2019).
Micro-evolution of three Streptococcus species: Selection, antigenic variation,
and horizontal gene inflow. BMC Evolutionary Biology. Springer Nature.
https://doi.org/10.1186/s12862-019-1403-6'
chicago: 'Shelyakin, Pavel V., Olga Bochkareva, Anna A. Karan, and Mikhail S. Gelfand.
“Micro-Evolution of Three Streptococcus Species: Selection, Antigenic Variation,
and Horizontal Gene Inflow.” BMC Evolutionary Biology. Springer Nature,
2019. https://doi.org/10.1186/s12862-019-1403-6.'
ieee: 'P. V. Shelyakin, O. Bochkareva, A. A. Karan, and M. S. Gelfand, “Micro-evolution
of three Streptococcus species: Selection, antigenic variation, and horizontal
gene inflow,” BMC Evolutionary Biology, vol. 19. Springer Nature, 2019.'
ista: 'Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. 2019. Micro-evolution of
three Streptococcus species: Selection, antigenic variation, and horizontal gene
inflow. BMC Evolutionary Biology. 19, 83.'
mla: 'Shelyakin, Pavel V., et al. “Micro-Evolution of Three Streptococcus Species:
Selection, Antigenic Variation, and Horizontal Gene Inflow.” BMC Evolutionary
Biology, vol. 19, 83, Springer Nature, 2019, doi:10.1186/s12862-019-1403-6.'
short: P.V. Shelyakin, O. Bochkareva, A.A. Karan, M.S. Gelfand, BMC Evolutionary
Biology 19 (2019).
date_created: 2020-08-15T11:04:07Z
date_published: 2019-03-27T00:00:00Z
date_updated: 2023-02-23T13:28:54Z
day: '27'
doi: 10.1186/s12862-019-1403-6
extern: '1'
intvolume: ' 19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1186/s12862-019-1403-6
month: '03'
oa: 1
oa_version: Published Version
publication: BMC Evolutionary Biology
publication_identifier:
issn:
- 1471-2148
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Micro-evolution of three Streptococcus species: Selection, antigenic variation,
and horizontal gene inflow'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2019'
...
---
_id: '8296'
abstract:
- lang: eng
text: While showing great promise, smart contracts are difficult to program correctly,
as they need a deep understanding of cryptography and distributed algorithms,
and offer limited functionality, as they have to be deterministic and cannot operate
on secret data. In this paper we present Protean, a general-purpose decentralized
computing platform that addresses these limitations by moving from a monolithic
execution model, where all participating nodes store all the state and execute
every computation, to a modular execution-model. Protean employs secure specialized
modules, called functional units, for building decentralized applications that
are currently insecure or impossible to implement with smart contracts. Each functional
unit is a distributed system that provides a special-purpose functionality by
exposing atomic transactions to the smart-contract developer. Combining these
transactions into arbitrarily-defined workflows, developers can build a larger
class of decentralized applications, such as provably-secure and fair lotteries
or e-voting.
article_processing_charge: No
author:
- first_name: Enis Ceyhun
full_name: Alp, Enis Ceyhun
last_name: Alp
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Georgia
full_name: Fragkouli, Georgia
last_name: Fragkouli
- first_name: Bryan
full_name: Ford, Bryan
last_name: Ford
citation:
ama: 'Alp EC, Kokoris Kogias E, Fragkouli G, Ford B. Rethinking general-purpose
decentralized computing. In: Proceedings of the Workshop on Hot Topics in Operating
Systems. ACM; 2019:105-112. doi:10.1145/3317550.3321448'
apa: 'Alp, E. C., Kokoris Kogias, E., Fragkouli, G., & Ford, B. (2019). Rethinking
general-purpose decentralized computing. In Proceedings of the Workshop on
Hot Topics in Operating Systems (pp. 105–112). Bertinoro, Italy: ACM. https://doi.org/10.1145/3317550.3321448'
chicago: Alp, Enis Ceyhun, Eleftherios Kokoris Kogias, Georgia Fragkouli, and Bryan
Ford. “Rethinking General-Purpose Decentralized Computing.” In Proceedings
of the Workshop on Hot Topics in Operating Systems, 105–12. ACM, 2019. https://doi.org/10.1145/3317550.3321448.
ieee: E. C. Alp, E. Kokoris Kogias, G. Fragkouli, and B. Ford, “Rethinking general-purpose
decentralized computing,” in Proceedings of the Workshop on Hot Topics in Operating
Systems, Bertinoro, Italy, 2019, pp. 105–112.
ista: 'Alp EC, Kokoris Kogias E, Fragkouli G, Ford B. 2019. Rethinking general-purpose
decentralized computing. Proceedings of the Workshop on Hot Topics in Operating
Systems. HotOS: Workshop on Hot Topics in Operating Systems, 105–112.'
mla: Alp, Enis Ceyhun, et al. “Rethinking General-Purpose Decentralized Computing.”
Proceedings of the Workshop on Hot Topics in Operating Systems, ACM, 2019,
pp. 105–12, doi:10.1145/3317550.3321448.
short: E.C. Alp, E. Kokoris Kogias, G. Fragkouli, B. Ford, in:, Proceedings of the
Workshop on Hot Topics in Operating Systems, ACM, 2019, pp. 105–112.
conference:
end_date: 2019-05-15
location: Bertinoro, Italy
name: 'HotOS: Workshop on Hot Topics in Operating Systems'
start_date: 2019-05-13
date_created: 2020-08-26T11:45:45Z
date_published: 2019-05-01T00:00:00Z
date_updated: 2021-01-12T08:17:56Z
day: '01'
doi: 10.1145/3317550.3321448
extern: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 105-112
publication: Proceedings of the Workshop on Hot Topics in Operating Systems
publication_identifier:
isbn:
- '9781450367271'
publication_status: published
publisher: ACM
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rethinking general-purpose decentralized computing
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '8304'
abstract:
- lang: eng
text: "Enabling secure communication across distributed systems is usually studied
under the assumption of trust between the different systems and an external adversary
trying to compromise the messages. With the appearance of distributed ledgers
or blockchains, numerous protocols have emerged, which attempt to achieve trustless
communication between distrusting ledgers and participants. Cross-chain communication
(CCC) thereby plays a fundamental role in cryptocurrency exchanges, sharding,
bootstrapping of new and feature-extension of existing distributed ledgers. Unfortunately,
existing proposals are designed ad-hoc for specific use-cases, making it hard
to gain confidence on their correctness and composability.\r\nWe provide the first
systematic exposition of protocols for CCC. First, we formalize the underlying
research problem and show that CCC is impossible without a trusted third party,
contrary to common beliefs in the blockchain community. We then develop a framework
to evaluate existing and to design new cross-chain protocols. The framework is
based on the use case, the trust model, and the security assumptions of interlinked
blockchains. Finally, we identify security and privacy challenges faced by protocols
in the cross-chain setting.\r\nThis Systematization of Knowledge (SoK) offers
a comprehensive guide for designing protocols bridging the numerous distributed
ledgers available today. It aims to facilitate clearer communication between academia
and industry in the field."
article_number: 2019/1128
article_processing_charge: No
author:
- first_name: Alexei
full_name: Zamyatin, Alexei
last_name: Zamyatin
- first_name: Mustafa
full_name: Al-Bassam, Mustafa
last_name: Al-Bassam
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Pedro
full_name: Moreno-Sanchez, Pedro
last_name: Moreno-Sanchez
- first_name: Aggelos
full_name: Kiayias, Aggelos
last_name: Kiayias
- first_name: William J.
full_name: Knottenbelt, William J.
last_name: Knottenbelt
citation:
ama: 'Zamyatin A, Al-Bassam M, Zindros D, et al. SoK: Communication across distributed
ledgers. Cryptology ePrint Archive.'
apa: 'Zamyatin, A., Al-Bassam, M., Zindros, D., Kokoris Kogias, E., Moreno-Sanchez,
P., Kiayias, A., & Knottenbelt, W. J. (n.d.). SoK: Communication across distributed
ledgers. Cryptology ePrint Archive.'
chicago: 'Zamyatin, Alexei, Mustafa Al-Bassam, Dionysis Zindros, Eleftherios Kokoris
Kogias, Pedro Moreno-Sanchez, Aggelos Kiayias, and William J. Knottenbelt. “SoK:
Communication across Distributed Ledgers.” Cryptology EPrint Archive, n.d.'
ieee: 'A. Zamyatin et al., “SoK: Communication across distributed ledgers,”
Cryptology ePrint Archive. .'
ista: 'Zamyatin A, Al-Bassam M, Zindros D, Kokoris Kogias E, Moreno-Sanchez P, Kiayias
A, Knottenbelt WJ. SoK: Communication across distributed ledgers. Cryptology ePrint
Archive, 2019/1128.'
mla: 'Zamyatin, Alexei, et al. “SoK: Communication across Distributed Ledgers.”
Cryptology EPrint Archive, 2019/1128.'
short: A. Zamyatin, M. Al-Bassam, D. Zindros, E. Kokoris Kogias, P. Moreno-Sanchez,
A. Kiayias, W.J. Knottenbelt, Cryptology EPrint Archive (n.d.).
date_created: 2020-08-26T12:16:38Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2021-09-24T12:08:14Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://eprint.iacr.org/2019/1128 '
month: '10'
oa: 1
oa_version: Preprint
publication: Cryptology ePrint Archive
publication_status: submitted
status: public
title: 'SoK: Communication across distributed ledgers'
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '8303'
abstract:
- lang: eng
text: 'ByzCoin, a promising alternative of Bitcoin, is a scalable consensus protocol
used as a building block of many research and enterprise-level decentralized systems.
In this paper, we show that ByzCoin is unsuitable for deployment in an anopen,
adversarial network and instead introduceMOTOR. MOTORis designed as a secure,
robust, and scalable consensus suitable for permissionless sharded blockchains.
MOTORachieves these properties by making four key design choices: (a) it prioritizes
robustness in adversarial environments while maintaining adequate scalability,
(b) it employees provably correct cryptography that resists DoS attacks from individual
nodes, (c) it deploys unpredictable rotating leaders to defend against mildly-adaptive
adversaries and prevents censorship, and (d) it creates an incentive compatible
reward mechanism. These choices are materialized as (a) a “rotating subleader”
communication pattern that balances the scalability needs with the robustness
requirements under failures, (b) deployment of provable secure BLS multi-signatures,
(c) use of deterministic thresh-old signatures as a source of randomness and (d)
careful design of the reward allocation mechanism. We have implemented MOTORand
compare it withByzCoin. We show that MOTORcan scale similar to ByzCoin with an
at most2xoverhead whereas it maintains good performance even under high-percentage
of faults, unlike ByzCoin.'
article_number: 2019/676
article_processing_charge: No
author:
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
citation:
ama: Kokoris Kogias E. Robust and scalable consensus for sharded distributed ledgers.
Cryptology ePrint Archive.
apa: Kokoris Kogias, E. (n.d.). Robust and scalable consensus for sharded distributed
ledgers. Cryptology ePrint Archive.
chicago: Kokoris Kogias, Eleftherios. “Robust and Scalable Consensus for Sharded
Distributed Ledgers.” Cryptology EPrint Archive, n.d.
ieee: E. Kokoris Kogias, “Robust and scalable consensus for sharded distributed
ledgers,” Cryptology ePrint Archive. .
ista: Kokoris Kogias E. Robust and scalable consensus for sharded distributed ledgers.
Cryptology ePrint Archive, 2019/676.
mla: Kokoris Kogias, Eleftherios. “Robust and Scalable Consensus for Sharded Distributed
Ledgers.” Cryptology EPrint Archive, 2019/676.
short: E. Kokoris Kogias, Cryptology EPrint Archive (n.d.).
date_created: 2020-08-26T12:13:56Z
date_published: 2019-06-06T00:00:00Z
date_updated: 2021-09-24T12:07:11Z
day: '06'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/676
month: '06'
oa: 1
oa_version: Preprint
publication: Cryptology ePrint Archive
publication_status: submitted
status: public
title: Robust and scalable consensus for sharded distributed ledgers
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '8311'
abstract:
- lang: eng
text: 'One of the core promises of blockchain technology is that of enabling trustworthy
data dissemination in a trustless environment. What current blockchain systems
deliver, however, is slow dissemination of public data, rendering blockchain technology
unusable in settings where latency, transaction capacity, or data confidentiality
are important. In this thesis we focus on providing solutions on two of the most
pressing problems blockchain technology currently faces: scalability and data
confidentiality. To address the scalability issue, we present OMNILEDGER, a novel
scale-out distributed ledger that preserves long-term security under permissionless
operation. It ensures security and correctness by using a bias-resistant public-randomness
protocol for choosing large, statistically representative shards that process
transactions, and by introducing an efficient cross-shard commit protocol that
atomically handles transactions affecting multiple shards. To enable secure sharing
of confidential data we present CALYPSO, the first fully decentralized, auditable
access-control framework for secure blockchain-based data sharing which builds
upon two abstractions. First, on-chain secrets enable collective management of
(verifiably shared) secrets under a Byzantine adversary where an access-control
blockchain enforces user-specific access rules and a secret-management cothority
administers encrypted data. Second, skipchain-based identity and access management
enables efficient administration of dynamic, sovereign identities and access policies
and, in particular, permits clients to maintain long-term relationships with respect
to evolving user identities thanks to the trust-delegating forward links of skipchains.
In order to build OMNILEDGER and CALYPSO, we first build a set of tools for efficient
decentralization, which are presented in Part II of this dissertation. These tools
can be used in decentralized and distributed systems to achieve (1) scalable consensus
(BYZCOIN), (2) bias- resistant distributed randomness creations (RANDHOUND), and
(3) relationship-keeping between independently updating communication endpoints
(SKIPCHAINIAC). Although we use this tools in the scope off this thesis, they
can be (and already have been) used in a far wider scope.'
article_processing_charge: No
author:
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
citation:
ama: Kokoris Kogias E. Secure, confidential blockchains providing high throughput
and low latency. 2019. doi:10.5075/epfl-thesis-7101
apa: Kokoris Kogias, E. (2019). Secure, confidential blockchains providing high
throughput and low latency. École Polytechnique Fédérale de Lausanne. https://doi.org/10.5075/epfl-thesis-7101
chicago: Kokoris Kogias, Eleftherios. “Secure, Confidential Blockchains Providing
High Throughput and Low Latency.” École Polytechnique Fédérale de Lausanne, 2019.
https://doi.org/10.5075/epfl-thesis-7101.
ieee: E. Kokoris Kogias, “Secure, confidential blockchains providing high throughput
and low latency,” École Polytechnique Fédérale de Lausanne, 2019.
ista: Kokoris Kogias E. 2019. Secure, confidential blockchains providing high throughput
and low latency. École Polytechnique Fédérale de Lausanne.
mla: Kokoris Kogias, Eleftherios. Secure, Confidential Blockchains Providing
High Throughput and Low Latency. École Polytechnique Fédérale de Lausanne,
2019, doi:10.5075/epfl-thesis-7101.
short: E. Kokoris Kogias, Secure, Confidential Blockchains Providing High Throughput
and Low Latency, École Polytechnique Fédérale de Lausanne, 2019.
date_created: 2020-08-27T11:22:24Z
date_published: 2019-09-27T00:00:00Z
date_updated: 2021-12-20T15:30:47Z
day: '27'
degree_awarded: PhD
doi: 10.5075/epfl-thesis-7101
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.5075/epfl-thesis-7101
month: '09'
oa: 1
oa_version: Published Version
page: '244'
publication_status: published
publisher: École Polytechnique Fédérale de Lausanne
status: public
supervisor:
- first_name: Bryan Alexander
full_name: Ford, Bryan Alexander
last_name: Ford
title: Secure, confidential blockchains providing high throughput and low latency
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '8314'
abstract:
- lang: eng
text: "Off-chain protocols (channels) are a promising solution to the scalability
and privacy challenges of blockchain payments. Current proposals, however, require
synchrony assumptions to preserve the safety of a channel, leaking to an adversary
the exact amount of time needed to control the network for a successful attack.
In this paper, we introduce Brick, the first payment channel that remains secure
under network asynchrony and concurrently provides correct incentives. The core
idea is to incorporate the conflict resolution process within the channel by introducing
a rational committee of external parties, called Wardens. Hence, if a party wants
to close a channel unilaterally, it can only get the committee's approval for
the last valid state. Brick provides sub-second latency because it does not employ
heavy-weight consensus. Instead,\r\nBrick uses consistent broadcast to announce
updates and close the channel, a light-weight abstraction that is powerful enough
to preserve safety and liveness to any rational parties. Furthermore, we consider
permissioned blockchains, where the additional property of auditability might
be desired for regulatory purposes. We introduce Brick+, an off-chain construction
that provides auditability on top of Brick without conflicting with its privacy
guarantees. We formally define the properties our payment channel construction
should fulfill, and prove that both Brick and Brick+ satisfy them. We also design
incentives for Brick such that honest and rational behavior aligns. Finally, we
provide a reference implementation of the smart contracts in Solidity."
article_number: '1905.11360'
article_processing_charge: No
author:
- first_name: Georgia
full_name: Avarikioti, Georgia
last_name: Avarikioti
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Roger
full_name: Wattenhofer, Roger
last_name: Wattenhofer
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
citation:
ama: 'Avarikioti G, Kokoris Kogias E, Wattenhofer R, Zindros D. Brick: Asynchronous
payment channels. arXiv.'
apa: 'Avarikioti, G., Kokoris Kogias, E., Wattenhofer, R., & Zindros, D. (n.d.).
Brick: Asynchronous payment channels. arXiv.'
chicago: 'Avarikioti, Georgia, Eleftherios Kokoris Kogias, Roger Wattenhofer, and
Dionysis Zindros. “Brick: Asynchronous Payment Channels.” ArXiv, n.d.'
ieee: 'G. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, and D. Zindros, “Brick:
Asynchronous payment channels,” arXiv. .'
ista: 'Avarikioti G, Kokoris Kogias E, Wattenhofer R, Zindros D. Brick: Asynchronous
payment channels. arXiv, 1905.11360.'
mla: 'Avarikioti, Georgia, et al. “Brick: Asynchronous Payment Channels.” ArXiv,
1905.11360.'
short: G. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, D. Zindros, ArXiv (n.d.).
date_created: 2020-08-27T11:36:54Z
date_published: 2019-05-27T00:00:00Z
date_updated: 2021-01-12T08:18:04Z
day: '27'
extern: '1'
external_id:
arxiv:
- '1905.11360'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.11360
month: '05'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: 'Brick: Asynchronous payment channels'
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '8315'
abstract:
- lang: eng
text: "Sharding distributed ledgers is the most promising on-chain solution for
scaling blockchain technology. In this work, we define and analyze the properties
a sharded distributed ledger should fulfill. More specifically, we show that a
sharded blockchain cannot be scalable under a fully adaptive adversary, but it
can scale up to $O(n/\\log n)$ under an epoch-adaptive adversary. This is possible
only if the distributed ledger creates succinct proofs of the valid state updates
at the end of each epoch. Our model builds upon and extends the Bitcoin backbone
protocol by defining consistency and\r\nscalability. Consistency encompasses the
need for atomic execution of cross-shard transactions to preserve safety, whereas
scalability encapsulates the speedup a sharded system can gain in comparison to
a non-sharded system. In\r\norder to show the power of our framework, we analyze
the most prominent sharded blockchains and either prove their correctness (OmniLedger,
RapidChain) under our model or pinpoint where they fail to balance the consistency
and\r\nscalability requirements (Elastico, Monoxide). "
article_number: '1910.10434'
article_processing_charge: No
author:
- first_name: Georgia
full_name: Avarikioti, Georgia
last_name: Avarikioti
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Roger
full_name: Wattenhofer, Roger
last_name: Wattenhofer
citation:
ama: 'Avarikioti G, Kokoris Kogias E, Wattenhofer R. Divide and scale: Formalization
of distributed ledger sharding protocols. arXiv.'
apa: 'Avarikioti, G., Kokoris Kogias, E., & Wattenhofer, R. (n.d.). Divide and
scale: Formalization of distributed ledger sharding protocols. arXiv.'
chicago: 'Avarikioti, Georgia, Eleftherios Kokoris Kogias, and Roger Wattenhofer.
“Divide and Scale: Formalization of Distributed Ledger Sharding Protocols.” ArXiv,
n.d.'
ieee: 'G. Avarikioti, E. Kokoris Kogias, and R. Wattenhofer, “Divide and scale:
Formalization of distributed ledger sharding protocols,” arXiv. .'
ista: 'Avarikioti G, Kokoris Kogias E, Wattenhofer R. Divide and scale: Formalization
of distributed ledger sharding protocols. arXiv, 1910.10434.'
mla: 'Avarikioti, Georgia, et al. “Divide and Scale: Formalization of Distributed
Ledger Sharding Protocols.” ArXiv, 1910.10434.'
short: G. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, ArXiv (n.d.).
date_created: 2020-08-27T11:37:43Z
date_published: 2019-10-23T00:00:00Z
date_updated: 2021-01-12T08:18:05Z
day: '23'
extern: '1'
external_id:
arxiv:
- '1910.10434'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1910.10434
month: '10'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: 'Divide and scale: Formalization of distributed ledger sharding protocols'
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '8313'
abstract:
- lang: eng
text: The present invention concerns a computer-implemented method for secure data
exchange between a sender (A) and a recipient (B), wherein the method is performed
by the sender (A) and comprises encrypting data using a symmetric key k, creating
a write transaction T W , wherein the write transaction T W comprises information
usable to derive the symmetric key k and an access policy identifying the recipient
(B) as being allowed to decrypt the encrypted data, providing the recipient (B)
access to the encrypted data, and sending the write transaction T W to a first
group of servers (AC) for being stored in a blockchain data structure maintained
by the first group of servers (AC).
applicant:
- 'École Polytechnique Fédérale De Lausanne '
article_processing_charge: No
author:
- first_name: Bryan
full_name: Ford, Bryan
last_name: Ford
- first_name: Linus
full_name: Gasser, Linus
last_name: Gasser
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Philipp
full_name: Janovic, Philipp
last_name: Janovic
citation:
ama: Ford B, Gasser L, Kokoris Kogias E, Janovic P. Methods and systems for secure
data exchange. 2019.
apa: Ford, B., Gasser, L., Kokoris Kogias, E., & Janovic, P. (2019). Methods
and systems for secure data exchange.
chicago: Ford, Bryan, Linus Gasser, Eleftherios Kokoris Kogias, and Philipp Janovic.
“Methods and Systems for Secure Data Exchange,” 2019.
ieee: B. Ford, L. Gasser, E. Kokoris Kogias, and P. Janovic, “Methods and systems
for secure data exchange.” 2019.
ista: Ford B, Gasser L, Kokoris Kogias E, Janovic P. 2019. Methods and systems for
secure data exchange.
mla: Ford, Bryan, et al. Methods and Systems for Secure Data Exchange. 2019.
short: B. Ford, L. Gasser, E. Kokoris Kogias, P. Janovic, (2019).
date_created: 2020-08-27T11:24:44Z
date_published: 2019-08-22T00:00:00Z
date_updated: 2022-01-05T14:00:32Z
day: '22'
extern: '1'
ipc: G06F21/62 ; H04L9/08 ; H04L9/32
ipn: WO2019158209 (A1)
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/WO2019158209A1
month: '08'
oa: 1
oa_version: Published Version
publication_date: 2019-08-22
status: public
title: Methods and systems for secure data exchange
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '8405'
abstract:
- lang: eng
text: Atomic-resolution structure determination is crucial for understanding protein
function. Cryo-EM and NMR spectroscopy both provide structural information, but
currently cryo-EM does not routinely give access to atomic-level structural data,
and, generally, NMR structure determination is restricted to small (<30 kDa) proteins.
We introduce an integrated structure determination approach that simultaneously
uses NMR and EM data to overcome the limits of each of these methods. The approach
enables structure determination of the 468 kDa large dodecameric aminopeptidase
TET2 to a precision and accuracy below 1 Å by combining secondary-structure information
obtained from near-complete magic-angle-spinning NMR assignments of the 39 kDa-large
subunits, distance restraints from backbone amides and ILV methyl groups, and
a 4.1 Å resolution EM map. The resulting structure exceeds current standards of
NMR and EM structure determination in terms of molecular weight and precision.
Importantly, the approach is successful even in cases where only medium-resolution
cryo-EM data are available.
article_number: '2697'
article_processing_charge: No
article_type: original
author:
- first_name: Diego F.
full_name: Gauto, Diego F.
last_name: Gauto
- first_name: Leandro F.
full_name: Estrozi, Leandro F.
last_name: Estrozi
- first_name: Charles D.
full_name: Schwieters, Charles D.
last_name: Schwieters
- first_name: Gregory
full_name: Effantin, Gregory
last_name: Effantin
- first_name: Pavel
full_name: Macek, Pavel
last_name: Macek
- first_name: Remy
full_name: Sounier, Remy
last_name: Sounier
- first_name: Astrid C.
full_name: Sivertsen, Astrid C.
last_name: Sivertsen
- first_name: Elena
full_name: Schmidt, Elena
last_name: Schmidt
- first_name: Rime
full_name: Kerfah, Rime
last_name: Kerfah
- first_name: Guillaume
full_name: Mas, Guillaume
last_name: Mas
- first_name: Jacques-Philippe
full_name: Colletier, Jacques-Philippe
last_name: Colletier
- first_name: Peter
full_name: Güntert, Peter
last_name: Güntert
- first_name: Adrien
full_name: Favier, Adrien
last_name: Favier
- first_name: Guy
full_name: Schoehn, Guy
last_name: Schoehn
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Jerome
full_name: Boisbouvier, Jerome
last_name: Boisbouvier
citation:
ama: Gauto DF, Estrozi LF, Schwieters CD, et al. Integrated NMR and cryo-EM atomic-resolution
structure determination of a half-megadalton enzyme complex. Nature Communications.
2019;10. doi:10.1038/s41467-019-10490-9
apa: Gauto, D. F., Estrozi, L. F., Schwieters, C. D., Effantin, G., Macek, P., Sounier,
R., … Boisbouvier, J. (2019). Integrated NMR and cryo-EM atomic-resolution structure
determination of a half-megadalton enzyme complex. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-019-10490-9
chicago: Gauto, Diego F., Leandro F. Estrozi, Charles D. Schwieters, Gregory Effantin,
Pavel Macek, Remy Sounier, Astrid C. Sivertsen, et al. “Integrated NMR and Cryo-EM
Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.”
Nature Communications. Springer Nature, 2019. https://doi.org/10.1038/s41467-019-10490-9.
ieee: D. F. Gauto et al., “Integrated NMR and cryo-EM atomic-resolution structure
determination of a half-megadalton enzyme complex,” Nature Communications,
vol. 10. Springer Nature, 2019.
ista: Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen
AC, Schmidt E, Kerfah R, Mas G, Colletier J-P, Güntert P, Favier A, Schoehn G,
Schanda P, Boisbouvier J. 2019. Integrated NMR and cryo-EM atomic-resolution structure
determination of a half-megadalton enzyme complex. Nature Communications. 10,
2697.
mla: Gauto, Diego F., et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure
Determination of a Half-Megadalton Enzyme Complex.” Nature Communications,
vol. 10, 2697, Springer Nature, 2019, doi:10.1038/s41467-019-10490-9.
short: D.F. Gauto, L.F. Estrozi, C.D. Schwieters, G. Effantin, P. Macek, R. Sounier,
A.C. Sivertsen, E. Schmidt, R. Kerfah, G. Mas, J.-P. Colletier, P. Güntert, A.
Favier, G. Schoehn, P. Schanda, J. Boisbouvier, Nature Communications 10 (2019).
date_created: 2020-09-17T10:28:25Z
date_published: 2019-06-19T00:00:00Z
date_updated: 2021-01-12T08:19:03Z
day: '19'
doi: 10.1038/s41467-019-10490-9
extern: '1'
external_id:
pmid:
- '31217444'
intvolume: ' 10'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- General Physics and Astronomy
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-019-10490-9
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton
enzyme complex
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2019'
...
---
_id: '8406'
abstract:
- lang: eng
text: Coordinated conformational transitions in oligomeric enzymatic complexes modulate
function in response to substrates and play a crucial role in enzyme inhibition
and activation. Caseinolytic protease (ClpP) is a tetradecameric complex, which
has emerged as a drug target against multiple pathogenic bacteria. Activation
of different ClpPs by inhibitors has been independently reported from drug development
efforts, but no rationale for inhibitor-induced activation has been hitherto proposed.
Using an integrated approach that includes x-ray crystallography, solid- and solution-state
nuclear magnetic resonance, molecular dynamics simulations, and isothermal titration
calorimetry, we show that the proteasome inhibitor bortezomib binds to the ClpP
active-site serine, mimicking a peptide substrate, and induces a concerted allosteric
activation of the complex. The bortezomib-activated conformation also exhibits
a higher affinity for its cognate unfoldase ClpX. We propose a universal allosteric
mechanism, where substrate binding to a single subunit locks ClpP into an active
conformation optimized for chaperone association and protein processive degradation.
article_number: eaaw3818
article_processing_charge: No
article_type: original
author:
- first_name: Jan
full_name: Felix, Jan
last_name: Felix
- first_name: Katharina
full_name: Weinhäupl, Katharina
last_name: Weinhäupl
- first_name: Christophe
full_name: Chipot, Christophe
last_name: Chipot
- first_name: François
full_name: Dehez, François
last_name: Dehez
- first_name: Audrey
full_name: Hessel, Audrey
last_name: Hessel
- first_name: Diego F.
full_name: Gauto, Diego F.
last_name: Gauto
- first_name: Cecile
full_name: Morlot, Cecile
last_name: Morlot
- first_name: Olga
full_name: Abian, Olga
last_name: Abian
- first_name: Irina
full_name: Gutsche, Irina
last_name: Gutsche
- first_name: Adrian
full_name: Velazquez-Campoy, Adrian
last_name: Velazquez-Campoy
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Hugo
full_name: Fraga, Hugo
last_name: Fraga
citation:
ama: Felix J, Weinhäupl K, Chipot C, et al. Mechanism of the allosteric activation
of the ClpP protease machinery by substrates and active-site inhibitors. Science
Advances. 2019;5(9). doi:10.1126/sciadv.aaw3818
apa: Felix, J., Weinhäupl, K., Chipot, C., Dehez, F., Hessel, A., Gauto, D. F.,
… Fraga, H. (2019). Mechanism of the allosteric activation of the ClpP protease
machinery by substrates and active-site inhibitors. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aaw3818
chicago: Felix, Jan, Katharina Weinhäupl, Christophe Chipot, François Dehez, Audrey
Hessel, Diego F. Gauto, Cecile Morlot, et al. “Mechanism of the Allosteric Activation
of the ClpP Protease Machinery by Substrates and Active-Site Inhibitors.” Science
Advances. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/sciadv.aaw3818.
ieee: J. Felix et al., “Mechanism of the allosteric activation of the ClpP
protease machinery by substrates and active-site inhibitors,” Science Advances,
vol. 5, no. 9. American Association for the Advancement of Science, 2019.
ista: Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian
O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H. 2019. Mechanism of the allosteric
activation of the ClpP protease machinery by substrates and active-site inhibitors.
Science Advances. 5(9), eaaw3818.
mla: Felix, Jan, et al. “Mechanism of the Allosteric Activation of the ClpP Protease
Machinery by Substrates and Active-Site Inhibitors.” Science Advances,
vol. 5, no. 9, eaaw3818, American Association for the Advancement of Science,
2019, doi:10.1126/sciadv.aaw3818.
short: J. Felix, K. Weinhäupl, C. Chipot, F. Dehez, A. Hessel, D.F. Gauto, C. Morlot,
O. Abian, I. Gutsche, A. Velazquez-Campoy, P. Schanda, H. Fraga, Science Advances
5 (2019).
date_created: 2020-09-17T10:28:36Z
date_published: 2019-09-04T00:00:00Z
date_updated: 2021-01-12T08:19:03Z
day: '04'
doi: 10.1126/sciadv.aaw3818
extern: '1'
intvolume: ' 5'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.1126/sciadv.aaw3818'
month: '09'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
issn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Mechanism of the allosteric activation of the ClpP protease machinery by substrates
and active-site inhibitors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2019'
...
---
_id: '8413'
abstract:
- lang: eng
text: NMR relaxation dispersion methods provide a holistic way to observe microsecond
time-scale protein backbone motion both in solution and in the solid state. Different
nuclei (1H and 15N) and different relaxation dispersion techniques (Bloch–McConnell
and near-rotary-resonance) give complementary information about the amplitudes
and time scales of the conformational dynamics and provide comprehensive insights
into the mechanistic details of the structural rearrangements. In this paper,
we exemplify the benefits of the combination of various solution- and solid-state
relaxation dispersion methods on a microcrystalline protein (α-spectrin SH3 domain),
for which we are able to identify and model the functionally relevant conformational
rearrangements around the ligand recognition loop occurring on multiple microsecond
time scales. The observed loop motions suggest that the SH3 domain exists in a
binding-competent conformation in dynamic equilibrium with a sterically impaired
ground-state conformation both in solution and in crystalline form. This inherent
plasticity between the interconverting macrostates is compatible with a conformational-preselection
model and provides new insights into the recognition mechanisms of SH3 domains.
article_processing_charge: No
article_type: original
author:
- first_name: Petra
full_name: Rovó, Petra
last_name: Rovó
- first_name: Colin A.
full_name: Smith, Colin A.
last_name: Smith
- first_name: Diego
full_name: Gauto, Diego
last_name: Gauto
- first_name: Bert L.
full_name: de Groot, Bert L.
last_name: de Groot
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Rasmus
full_name: Linser, Rasmus
last_name: Linser
citation:
ama: Rovó P, Smith CA, Gauto D, de Groot BL, Schanda P, Linser R. Mechanistic insights
into microsecond time-scale motion of solid proteins using complementary 15N and
1H relaxation dispersion techniques. Journal of the American Chemical Society.
2019;141(2):858-869. doi:10.1021/jacs.8b09258
apa: Rovó, P., Smith, C. A., Gauto, D., de Groot, B. L., Schanda, P., & Linser,
R. (2019). Mechanistic insights into microsecond time-scale motion of solid proteins
using complementary 15N and 1H relaxation dispersion techniques. Journal of
the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.8b09258
chicago: Rovó, Petra, Colin A. Smith, Diego Gauto, Bert L. de Groot, Paul Schanda,
and Rasmus Linser. “Mechanistic Insights into Microsecond Time-Scale Motion of
Solid Proteins Using Complementary 15N and 1H Relaxation Dispersion Techniques.”
Journal of the American Chemical Society. American Chemical Society, 2019.
https://doi.org/10.1021/jacs.8b09258.
ieee: P. Rovó, C. A. Smith, D. Gauto, B. L. de Groot, P. Schanda, and R. Linser,
“Mechanistic insights into microsecond time-scale motion of solid proteins using
complementary 15N and 1H relaxation dispersion techniques,” Journal of the
American Chemical Society, vol. 141, no. 2. American Chemical Society, pp.
858–869, 2019.
ista: Rovó P, Smith CA, Gauto D, de Groot BL, Schanda P, Linser R. 2019. Mechanistic
insights into microsecond time-scale motion of solid proteins using complementary
15N and 1H relaxation dispersion techniques. Journal of the American Chemical
Society. 141(2), 858–869.
mla: Rovó, Petra, et al. “Mechanistic Insights into Microsecond Time-Scale Motion
of Solid Proteins Using Complementary 15N and 1H Relaxation Dispersion Techniques.”
Journal of the American Chemical Society, vol. 141, no. 2, American Chemical
Society, 2019, pp. 858–69, doi:10.1021/jacs.8b09258.
short: P. Rovó, C.A. Smith, D. Gauto, B.L. de Groot, P. Schanda, R. Linser, Journal
of the American Chemical Society 141 (2019) 858–869.
date_created: 2020-09-17T10:29:50Z
date_published: 2019-01-08T00:00:00Z
date_updated: 2021-01-12T08:19:07Z
day: '08'
doi: 10.1021/jacs.8b09258
extern: '1'
external_id:
pmid:
- '30620186'
intvolume: ' 141'
issue: '2'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '01'
oa_version: Submitted Version
page: 858-869
pmid: 1
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Mechanistic insights into microsecond time-scale motion of solid proteins using
complementary 15N and 1H relaxation dispersion techniques
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 141
year: '2019'
...
---
_id: '8412'
abstract:
- lang: eng
text: Microsecond to millisecond timescale backbone dynamics of the amyloid core
residues in Y145Stop human prion protein (PrP) fibrils were investigated by using
15N rotating frame (R1ρ) relaxation dispersion solid‐state nuclear magnetic resonance
spectroscopy over a wide range of spin‐lock fields. Numerical simulations enabled
the experimental relaxation dispersion profiles for most of the fibril core residues
to be modelled by using a two‐state exchange process with a common exchange rate
of 1000 s−1, corresponding to protein backbone motion on the timescale of 1 ms,
and an excited‐state population of 2 %. We also found that the relaxation dispersion
profiles for several amino acids positioned near the edges of the most structured
regions of the amyloid core were better modelled by assuming somewhat higher excited‐state
populations (∼5–15 %) and faster exchange rate constants, corresponding to protein
backbone motions on the timescale of ∼100–300 μs. The slow backbone dynamics of
the core residues were evaluated in the context of the structural model of human
Y145Stop PrP amyloid.
article_processing_charge: No
article_type: original
author:
- first_name: Matthew D.
full_name: Shannon, Matthew D.
last_name: Shannon
- first_name: Theint
full_name: Theint, Theint
last_name: Theint
- first_name: Dwaipayan
full_name: Mukhopadhyay, Dwaipayan
last_name: Mukhopadhyay
- first_name: Krystyna
full_name: Surewicz, Krystyna
last_name: Surewicz
- first_name: Witold K.
full_name: Surewicz, Witold K.
last_name: Surewicz
- first_name: Dominique
full_name: Marion, Dominique
last_name: Marion
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Christopher P.
full_name: Jaroniec, Christopher P.
last_name: Jaroniec
citation:
ama: Shannon MD, Theint T, Mukhopadhyay D, et al. Conformational dynamics in the
core of human Y145Stop prion protein amyloid probed by relaxation dispersion NMR.
ChemPhysChem. 2019;20(2):311-317. doi:10.1002/cphc.201800779
apa: Shannon, M. D., Theint, T., Mukhopadhyay, D., Surewicz, K., Surewicz, W. K.,
Marion, D., … Jaroniec, C. P. (2019). Conformational dynamics in the core of human
Y145Stop prion protein amyloid probed by relaxation dispersion NMR. ChemPhysChem.
Wiley. https://doi.org/10.1002/cphc.201800779
chicago: Shannon, Matthew D., Theint Theint, Dwaipayan Mukhopadhyay, Krystyna Surewicz,
Witold K. Surewicz, Dominique Marion, Paul Schanda, and Christopher P. Jaroniec.
“Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed
by Relaxation Dispersion NMR.” ChemPhysChem. Wiley, 2019. https://doi.org/10.1002/cphc.201800779.
ieee: M. D. Shannon et al., “Conformational dynamics in the core of human
Y145Stop prion protein amyloid probed by relaxation dispersion NMR,” ChemPhysChem,
vol. 20, no. 2. Wiley, pp. 311–317, 2019.
ista: Shannon MD, Theint T, Mukhopadhyay D, Surewicz K, Surewicz WK, Marion D, Schanda
P, Jaroniec CP. 2019. Conformational dynamics in the core of human Y145Stop prion
protein amyloid probed by relaxation dispersion NMR. ChemPhysChem. 20(2), 311–317.
mla: Shannon, Matthew D., et al. “Conformational Dynamics in the Core of Human Y145Stop
Prion Protein Amyloid Probed by Relaxation Dispersion NMR.” ChemPhysChem,
vol. 20, no. 2, Wiley, 2019, pp. 311–17, doi:10.1002/cphc.201800779.
short: M.D. Shannon, T. Theint, D. Mukhopadhyay, K. Surewicz, W.K. Surewicz, D.
Marion, P. Schanda, C.P. Jaroniec, ChemPhysChem 20 (2019) 311–317.
date_created: 2020-09-17T10:29:43Z
date_published: 2019-01-21T00:00:00Z
date_updated: 2021-01-12T08:19:06Z
day: '21'
doi: 10.1002/cphc.201800779
extern: '1'
external_id:
pmid:
- '30276945'
intvolume: ' 20'
issue: '2'
keyword:
- Physical and Theoretical Chemistry
- Atomic and Molecular Physics
- and Optics
language:
- iso: eng
month: '01'
oa_version: Submitted Version
page: 311-317
pmid: 1
publication: ChemPhysChem
publication_identifier:
issn:
- 1439-4235
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Conformational dynamics in the core of human Y145Stop prion protein amyloid
probed by relaxation dispersion NMR
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2019'
...
---
_id: '8411'
abstract:
- lang: eng
text: 'Studying protein dynamics on microsecond‐to‐millisecond (μs‐ms) time scales
can provide important insight into protein function. In magic‐angle‐spinning (MAS)
NMR, μs dynamics can be visualized by R1p rotating‐frame relaxation dispersion
experiments in different regimes of radio‐frequency field strengths: at low RF
field strength, isotropic‐chemical‐shift fluctuation leads to “Bloch‐McConnell‐type”
relaxation dispersion, while when the RF field approaches rotary resonance conditions
bond angle fluctuations manifest as increased R1p rate constants (“Near‐Rotary‐Resonance
Relaxation Dispersion”, NERRD). Here we explore the joint analysis of both regimes
to gain comprehensive insight into motion in terms of geometric amplitudes, chemical‐shift
changes, populations and exchange kinetics. We use a numerical simulation procedure
to illustrate these effects and the potential of extracting exchange parameters,
and apply the methodology to the study of a previously described conformational
exchange process in microcrystalline ubiquitin.'
article_processing_charge: No
article_type: original
author:
- first_name: Dominique
full_name: Marion, Dominique
last_name: Marion
- first_name: Diego F.
full_name: Gauto, Diego F.
last_name: Gauto
- first_name: Isabel
full_name: Ayala, Isabel
last_name: Ayala
- first_name: Karine
full_name: Giandoreggio-Barranco, Karine
last_name: Giandoreggio-Barranco
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Marion D, Gauto DF, Ayala I, Giandoreggio-Barranco K, Schanda P. Microsecond
protein dynamics from combined Bloch-McConnell and Near-Rotary-Resonance R1p relaxation-dispersion
MAS NMR. ChemPhysChem. 2019;20(2):276-284. doi:10.1002/cphc.201800935
apa: Marion, D., Gauto, D. F., Ayala, I., Giandoreggio-Barranco, K., & Schanda,
P. (2019). Microsecond protein dynamics from combined Bloch-McConnell and Near-Rotary-Resonance
R1p relaxation-dispersion MAS NMR. ChemPhysChem. Wiley. https://doi.org/10.1002/cphc.201800935
chicago: Marion, Dominique, Diego F. Gauto, Isabel Ayala, Karine Giandoreggio-Barranco,
and Paul Schanda. “Microsecond Protein Dynamics from Combined Bloch-McConnell
and Near-Rotary-Resonance R1p Relaxation-Dispersion MAS NMR.” ChemPhysChem.
Wiley, 2019. https://doi.org/10.1002/cphc.201800935.
ieee: D. Marion, D. F. Gauto, I. Ayala, K. Giandoreggio-Barranco, and P. Schanda,
“Microsecond protein dynamics from combined Bloch-McConnell and Near-Rotary-Resonance
R1p relaxation-dispersion MAS NMR,” ChemPhysChem, vol. 20, no. 2. Wiley,
pp. 276–284, 2019.
ista: Marion D, Gauto DF, Ayala I, Giandoreggio-Barranco K, Schanda P. 2019. Microsecond
protein dynamics from combined Bloch-McConnell and Near-Rotary-Resonance R1p relaxation-dispersion
MAS NMR. ChemPhysChem. 20(2), 276–284.
mla: Marion, Dominique, et al. “Microsecond Protein Dynamics from Combined Bloch-McConnell
and Near-Rotary-Resonance R1p Relaxation-Dispersion MAS NMR.” ChemPhysChem,
vol. 20, no. 2, Wiley, 2019, pp. 276–84, doi:10.1002/cphc.201800935.
short: D. Marion, D.F. Gauto, I. Ayala, K. Giandoreggio-Barranco, P. Schanda, ChemPhysChem
20 (2019) 276–284.
date_created: 2020-09-17T10:29:36Z
date_published: 2019-01-21T00:00:00Z
date_updated: 2021-01-12T08:19:06Z
day: '21'
doi: 10.1002/cphc.201800935
extern: '1'
external_id:
pmid:
- '30444575'
intvolume: ' 20'
issue: '2'
keyword:
- Physical and Theoretical Chemistry
- Atomic and Molecular Physics
- and Optics
language:
- iso: eng
month: '01'
oa_version: Submitted Version
page: 276-284
pmid: 1
publication: ChemPhysChem
publication_identifier:
issn:
- 1439-4235
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Microsecond protein dynamics from combined Bloch-McConnell and Near-Rotary-Resonance
R1p relaxation-dispersion MAS NMR
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2019'
...
---
_id: '8415'
abstract:
- lang: eng
text: 'We consider billiards obtained by removing three strictly convex obstacles
satisfying the non-eclipse condition on the plane. The restriction of the dynamics
to the set of non-escaping orbits is conjugated to a subshift on three symbols
that provides a natural labeling of all periodic orbits. We study the following
inverse problem: does the Marked Length Spectrum (i.e., the set of lengths of
periodic orbits together with their labeling), determine the geometry of the billiard
table? We show that from the Marked Length Spectrum it is possible to recover
the curvature at periodic points of period two, as well as the Lyapunov exponent
of each periodic orbit.'
article_processing_charge: No
article_type: original
author:
- first_name: Péter
full_name: Bálint, Péter
last_name: Bálint
- first_name: Jacopo
full_name: De Simoi, Jacopo
last_name: De Simoi
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Martin
full_name: Leguil, Martin
last_name: Leguil
citation:
ama: Bálint P, De Simoi J, Kaloshin V, Leguil M. Marked length spectrum, homoclinic
orbits and the geometry of open dispersing billiards. Communications in Mathematical
Physics. 2019;374(3):1531-1575. doi:10.1007/s00220-019-03448-x
apa: Bálint, P., De Simoi, J., Kaloshin, V., & Leguil, M. (2019). Marked length
spectrum, homoclinic orbits and the geometry of open dispersing billiards. Communications
in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-019-03448-x
chicago: Bálint, Péter, Jacopo De Simoi, Vadim Kaloshin, and Martin Leguil. “Marked
Length Spectrum, Homoclinic Orbits and the Geometry of Open Dispersing Billiards.”
Communications in Mathematical Physics. Springer Nature, 2019. https://doi.org/10.1007/s00220-019-03448-x.
ieee: P. Bálint, J. De Simoi, V. Kaloshin, and M. Leguil, “Marked length spectrum,
homoclinic orbits and the geometry of open dispersing billiards,” Communications
in Mathematical Physics, vol. 374, no. 3. Springer Nature, pp. 1531–1575,
2019.
ista: Bálint P, De Simoi J, Kaloshin V, Leguil M. 2019. Marked length spectrum,
homoclinic orbits and the geometry of open dispersing billiards. Communications
in Mathematical Physics. 374(3), 1531–1575.
mla: Bálint, Péter, et al. “Marked Length Spectrum, Homoclinic Orbits and the Geometry
of Open Dispersing Billiards.” Communications in Mathematical Physics,
vol. 374, no. 3, Springer Nature, 2019, pp. 1531–75, doi:10.1007/s00220-019-03448-x.
short: P. Bálint, J. De Simoi, V. Kaloshin, M. Leguil, Communications in Mathematical
Physics 374 (2019) 1531–1575.
date_created: 2020-09-17T10:41:27Z
date_published: 2019-05-09T00:00:00Z
date_updated: 2021-01-12T08:19:08Z
day: '09'
doi: 10.1007/s00220-019-03448-x
extern: '1'
external_id:
arxiv:
- '1809.08947'
intvolume: ' 374'
issue: '3'
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1809.08947
month: '05'
oa: 1
oa_version: Preprint
page: 1531-1575
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
- 1432-0916
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Marked length spectrum, homoclinic orbits and the geometry of open dispersing
billiards
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 374
year: '2019'
...