---
_id: '7128'
abstract:
- lang: eng
text: Loss of functional cardiomyocytes is a major determinant of heart failure
after myocardial infarction. Previous high throughput screening studies have identified
a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate
cardiac regeneration in mice. Here, we show that all of the most effective of
these miRNAs activate nuclear localization of the master transcriptional cofactor
Yes-associated protein (YAP) and induce expression of YAP-responsive genes. In
particular, miR-199a-3p directly targets two mRNAs coding for proteins impinging
on the Hippo pathway, the upstream YAP inhibitory kinase TAOK1, and the E3 ubiquitin
ligase β-TrCP, which leads to YAP degradation. Several of the pro-proliferative
miRNAs (including miR-199a-3p) also inhibit filamentous actin depolymerization
by targeting Cofilin2, a process that by itself activates YAP nuclear translocation.
Thus, activation of YAP and modulation of the actin cytoskeleton are major components
of the pro-proliferative action of miR-199a-3p and other miRNAs that induce cardiomyocyte
proliferation.
article_processing_charge: Yes
article_type: original
author:
- first_name: Consuelo
full_name: Torrini, Consuelo
last_name: Torrini
- first_name: Ryan J
full_name: Cubero, Ryan J
id: 850B2E12-9CD4-11E9-837F-E719E6697425
last_name: Cubero
orcid: 0000-0003-0002-1867
- first_name: Ellen
full_name: Dirkx, Ellen
last_name: Dirkx
- first_name: Luca
full_name: Braga, Luca
last_name: Braga
- first_name: Hashim
full_name: Ali, Hashim
last_name: Ali
- first_name: Giulia
full_name: Prosdocimo, Giulia
last_name: Prosdocimo
- first_name: Maria Ines
full_name: Gutierrez, Maria Ines
last_name: Gutierrez
- first_name: Chiara
full_name: Collesi, Chiara
last_name: Collesi
- first_name: Danilo
full_name: Licastro, Danilo
last_name: Licastro
- first_name: Lorena
full_name: Zentilin, Lorena
last_name: Zentilin
- first_name: Miguel
full_name: Mano, Miguel
last_name: Mano
- first_name: Serena
full_name: Zacchigna, Serena
last_name: Zacchigna
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Matteo
full_name: Marsili, Matteo
last_name: Marsili
- first_name: Areejit
full_name: Samal, Areejit
last_name: Samal
- first_name: Mauro
full_name: Giacca, Mauro
last_name: Giacca
citation:
ama: Torrini C, Cubero RJ, Dirkx E, et al. Common regulatory pathways mediate activity
of microRNAs inducing cardiomyocyte proliferation. Cell Reports. 2019;27(9):2759-2771.e5.
doi:10.1016/j.celrep.2019.05.005
apa: Torrini, C., Cubero, R. J., Dirkx, E., Braga, L., Ali, H., Prosdocimo, G.,
… Giacca, M. (2019). Common regulatory pathways mediate activity of microRNAs
inducing cardiomyocyte proliferation. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2019.05.005
chicago: Torrini, Consuelo, Ryan J Cubero, Ellen Dirkx, Luca Braga, Hashim Ali,
Giulia Prosdocimo, Maria Ines Gutierrez, et al. “Common Regulatory Pathways Mediate
Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.” Cell Reports.
Elsevier, 2019. https://doi.org/10.1016/j.celrep.2019.05.005.
ieee: C. Torrini et al., “Common regulatory pathways mediate activity of
microRNAs inducing cardiomyocyte proliferation,” Cell Reports, vol. 27,
no. 9. Elsevier, p. 2759–2771.e5, 2019.
ista: Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI,
Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili
M, Samal A, Giacca M. 2019. Common regulatory pathways mediate activity of microRNAs
inducing cardiomyocyte proliferation. Cell Reports. 27(9), 2759–2771.e5.
mla: Torrini, Consuelo, et al. “Common Regulatory Pathways Mediate Activity of MicroRNAs
Inducing Cardiomyocyte Proliferation.” Cell Reports, vol. 27, no. 9, Elsevier,
2019, p. 2759–2771.e5, doi:10.1016/j.celrep.2019.05.005.
short: C. Torrini, R.J. Cubero, E. Dirkx, L. Braga, H. Ali, G. Prosdocimo, M.I.
Gutierrez, C. Collesi, D. Licastro, L. Zentilin, M. Mano, S. Zacchigna, M. Vendruscolo,
M. Marsili, A. Samal, M. Giacca, Cell Reports 27 (2019) 2759–2771.e5.
date_created: 2019-11-26T22:30:07Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2021-01-12T08:11:56Z
day: '28'
ddc:
- '576'
doi: 10.1016/j.celrep.2019.05.005
extern: '1'
external_id:
pmid:
- '31141697'
file:
- access_level: open_access
checksum: c5d855d07263bfec718673385d0ea2d7
content_type: application/pdf
creator: rcubero
date_created: 2019-11-26T22:30:43Z
date_updated: 2020-07-14T12:47:50Z
file_id: '7129'
file_name: torrini_cellreports_2019.pdf
file_size: 4650750
relation: main_file
file_date_updated: 2020-07-14T12:47:50Z
has_accepted_license: '1'
intvolume: ' 27'
issue: '9'
keyword:
- cardiomyocyte
- cell cycle
- Cofilin2
- cytoskeleton
- Hippo
- microRNA
- regeneration
- YAP
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 2759-2771.e5
pmid: 1
publication: Cell Reports
publication_identifier:
issn:
- 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte
proliferation
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2019'
...
---
_id: '7130'
abstract:
- lang: eng
text: "We show that statistical criticality, i.e. the occurrence of power law frequency
distributions, arises in samples that are maximally informative about the underlying
generating process. In order to reach this conclusion, we first identify the frequency
with which different outcomes occur in a sample, as the variable carrying useful
information on the generative process. The entropy of the frequency, that we call
relevance, provides an upper bound to the number of informative bits. This differs
from the entropy of the data, that we take as a measure of resolution. Samples
that maximise relevance at a given resolution—that we call maximally informative
samples—exhibit statistical criticality. In particular, Zipf's law arises at the
optimal trade-off between resolution (i.e. compression) and relevance. As a byproduct,
we derive a bound of the maximal number of parameters that can be estimated from
a dataset, in the absence of prior knowledge on the generative model.\r\n\r\nFurthermore,
we relate criticality to the statistical properties of the representation of the
data generating process. We show that, as a consequence of the concentration property
of the asymptotic equipartition property, representations that are maximally informative
about the data generating process are characterised by an exponential distribution
of energy levels. This arises from a principle of minimal entropy, that is conjugate
of the maximum entropy principle in statistical mechanics. This explains why statistical
criticality requires no parameter fine tuning in maximally informative samples."
acknowledgement: We acknowledge interesting discussions with M Abbott, E Aurell, J
Barbier, R Monasson, T Mora, I Nemenman, N Tishby and R Zecchina. This research
was supported by the Kavli Foundation and the Centre of Excellence scheme of the
Research Council of Norway (Centre for Neural Computation) (RJC and YR), by the
Basic Science Research Program through the National Research Foundation of Korea
(NRF), funded by the Ministry of Education (2016R1D1A1B03932264) (JJ), and, in part,
by the ICTP through the OEA-AC-98 (JS).
article_number: '063402'
article_processing_charge: No
article_type: original
author:
- first_name: Ryan J
full_name: Cubero, Ryan J
id: 850B2E12-9CD4-11E9-837F-E719E6697425
last_name: Cubero
orcid: 0000-0003-0002-1867
- first_name: Junghyo
full_name: Jo, Junghyo
last_name: Jo
- first_name: Matteo
full_name: Marsili, Matteo
last_name: Marsili
- first_name: Yasser
full_name: Roudi, Yasser
last_name: Roudi
- first_name: Juyong
full_name: Song, Juyong
last_name: Song
citation:
ama: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. Statistical criticality arises
in most informative representations. Journal of Statistical Mechanics: Theory
and Experiment. 2019;2019(6). doi:10.1088/1742-5468/ab16c8'
apa: 'Cubero, R. J., Jo, J., Marsili, M., Roudi, Y., & Song, J. (2019). Statistical
criticality arises in most informative representations. Journal of Statistical
Mechanics: Theory and Experiment. IOP Publishing. https://doi.org/10.1088/1742-5468/ab16c8'
chicago: 'Cubero, Ryan J, Junghyo Jo, Matteo Marsili, Yasser Roudi, and Juyong Song.
“Statistical Criticality Arises in Most Informative Representations.” Journal
of Statistical Mechanics: Theory and Experiment. IOP Publishing, 2019. https://doi.org/10.1088/1742-5468/ab16c8.'
ieee: 'R. J. Cubero, J. Jo, M. Marsili, Y. Roudi, and J. Song, “Statistical criticality
arises in most informative representations,” Journal of Statistical Mechanics:
Theory and Experiment, vol. 2019, no. 6. IOP Publishing, 2019.'
ista: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. 2019. Statistical criticality
arises in most informative representations. Journal of Statistical Mechanics:
Theory and Experiment. 2019(6), 063402.'
mla: 'Cubero, Ryan J., et al. “Statistical Criticality Arises in Most Informative
Representations.” Journal of Statistical Mechanics: Theory and Experiment,
vol. 2019, no. 6, 063402, IOP Publishing, 2019, doi:10.1088/1742-5468/ab16c8.'
short: 'R.J. Cubero, J. Jo, M. Marsili, Y. Roudi, J. Song, Journal of Statistical
Mechanics: Theory and Experiment 2019 (2019).'
date_created: 2019-11-26T22:36:09Z
date_published: 2019-06-17T00:00:00Z
date_updated: 2021-01-12T08:11:57Z
day: '17'
doi: 10.1088/1742-5468/ab16c8
extern: '1'
external_id:
arxiv:
- '1808.00249'
intvolume: ' 2019'
issue: '6'
keyword:
- optimization under uncertainty
- source coding
- large deviation
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1808.00249
month: '06'
oa: 1
oa_version: Preprint
publication: 'Journal of Statistical Mechanics: Theory and Experiment'
publication_identifier:
issn:
- 1742-5468
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
status: public
title: Statistical criticality arises in most informative representations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2019
year: '2019'
...
---
_id: '7150'
abstract:
- lang: eng
text: "In this work, we use algebraic methods for studying distance computation
and subgraph detection tasks in the congested clique model. Specifically, we adapt
parallel matrix multiplication implementations to the congested clique, obtaining
an O(n1−2/ω) round matrix multiplication algorithm, where ω<2.3728639 is the exponent
of matrix multiplication. In conjunction with known techniques from centralised
algorithmics, this gives significant improvements over previous best upper bounds
in the congested clique model. The highlight results include:\r\n\r\n1. triangle
and 4-cycle counting in O(n0.158) rounds, improving upon the O(n1/3) algorithm
of Dolev et al. [DISC 2012],\r\n2. a (1+o(1))-approximation of all-pairs shortest
paths in O(n0.158) rounds, improving upon the O~(n1/2)-round (2+o(1))-approximation
algorithm given by Nanongkai [STOC 2014], and\r\n 3. computing the girth in O(n0.158)
rounds, which is the first non-trivial solution in this model.\r\n \r\nIn addition,
we present a novel constant-round combinatorial algorithm for detecting 4-cycles."
article_processing_charge: No
article_type: original
author:
- first_name: Keren
full_name: Censor-Hillel, Keren
last_name: Censor-Hillel
- first_name: Petteri
full_name: Kaski, Petteri
last_name: Kaski
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Christoph
full_name: Lenzen, Christoph
last_name: Lenzen
- first_name: Ami
full_name: Paz, Ami
last_name: Paz
- first_name: Jukka
full_name: Suomela, Jukka
last_name: Suomela
citation:
ama: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. Algebraic
methods in the congested clique. Distributed Computing. 2019;32(6):461-478.
doi:10.1007/s00446-016-0270-2
apa: Censor-Hillel, K., Kaski, P., Korhonen, J., Lenzen, C., Paz, A., & Suomela,
J. (2019). Algebraic methods in the congested clique. Distributed Computing.
Springer Nature. https://doi.org/10.1007/s00446-016-0270-2
chicago: Censor-Hillel, Keren, Petteri Kaski, Janne Korhonen, Christoph Lenzen,
Ami Paz, and Jukka Suomela. “Algebraic Methods in the Congested Clique.” Distributed
Computing. Springer Nature, 2019. https://doi.org/10.1007/s00446-016-0270-2.
ieee: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, and J. Suomela,
“Algebraic methods in the congested clique,” Distributed Computing, vol.
32, no. 6. Springer Nature, pp. 461–478, 2019.
ista: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. 2019. Algebraic
methods in the congested clique. Distributed Computing. 32(6), 461–478.
mla: Censor-Hillel, Keren, et al. “Algebraic Methods in the Congested Clique.” Distributed
Computing, vol. 32, no. 6, Springer Nature, 2019, pp. 461–78, doi:10.1007/s00446-016-0270-2.
short: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, J. Suomela, Distributed
Computing 32 (2019) 461–478.
date_created: 2019-12-05T09:49:49Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2021-01-12T08:12:05Z
day: '01'
doi: 10.1007/s00446-016-0270-2
extern: '1'
external_id:
arxiv:
- '1503.04963'
intvolume: ' 32'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1503.04963
month: '12'
oa: 1
oa_version: Preprint
page: 461-478
publication: Distributed Computing
publication_identifier:
issn:
- 0178-2770
- 1432-0452
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Algebraic methods in the congested clique
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2019'
...
---
_id: '7171'
abstract:
- lang: ger
text: "Wissen Sie, was sich hinter künstlicher Intelligenz und maschinellem Lernen
verbirgt? \r\nDieses Sachbuch erklärt Ihnen leicht verständlich und ohne komplizierte
Formeln die grundlegenden Methoden und Vorgehensweisen des maschinellen Lernens.
Mathematisches Vorwissen ist dafür nicht nötig. Kurzweilig und informativ illustriert
Lisa, die Protagonistin des Buches, diese anhand von Alltagssituationen. \r\nEin
Buch für alle, die in Diskussionen über Chancen und Risiken der aktuellen Entwicklung
der künstlichen Intelligenz und des maschinellen Lernens mit Faktenwissen punkten
möchten. Auch für Schülerinnen und Schüler geeignet!"
article_processing_charge: No
citation:
ama: 'Kersting K, Lampert C, Rothkopf C, eds. Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden: Springer Nature; 2019.
doi:10.1007/978-3-658-26763-6'
apa: 'Kersting, K., Lampert, C., & Rothkopf, C. (Eds.). (2019). Wie Maschinen
Lernen: Künstliche Intelligenz Verständlich Erklärt (1st ed.). Wiesbaden:
Springer Nature. https://doi.org/10.1007/978-3-658-26763-6'
chicago: 'Kersting, Kristian, Christoph Lampert, and Constantin Rothkopf, eds. Wie
Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden:
Springer Nature, 2019. https://doi.org/10.1007/978-3-658-26763-6.'
ieee: 'K. Kersting, C. Lampert, and C. Rothkopf, Eds., Wie Maschinen Lernen:
Künstliche Intelligenz Verständlich Erklärt, 1st ed. Wiesbaden: Springer Nature,
2019.'
ista: 'Kersting K, Lampert C, Rothkopf C eds. 2019. Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt 1st ed., Wiesbaden: Springer Nature, XIV, 245p.'
mla: 'Kersting, Kristian, et al., editors. Wie Maschinen Lernen: Künstliche Intelligenz
Verständlich Erklärt. 1st ed., Springer Nature, 2019, doi:10.1007/978-3-658-26763-6.'
short: 'K. Kersting, C. Lampert, C. Rothkopf, eds., Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt, 1st ed., Springer Nature, Wiesbaden, 2019.'
date_created: 2019-12-11T14:15:56Z
date_published: 2019-10-30T00:00:00Z
date_updated: 2021-12-22T14:40:58Z
day: '30'
department:
- _id: ChLa
doi: 10.1007/978-3-658-26763-6
edition: '1'
editor:
- first_name: Kristian
full_name: Kersting, Kristian
last_name: Kersting
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Constantin
full_name: Rothkopf, Constantin
last_name: Rothkopf
language:
- iso: ger
month: '10'
oa_version: None
page: XIV, 245
place: Wiesbaden
publication_identifier:
eisbn:
- 978-3-658-26763-6
isbn:
- 978-3-658-26762-9
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/book-release-how-machines-learn/
status: public
title: 'Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt'
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '7275'
abstract:
- lang: eng
text: Aprotic alkali metal–oxygen batteries require reversible formation of metal
superoxide or peroxide on cycling. Severe parasitic reactions cause poor rechargeability,
efficiency, and cycle life and have been shown to be caused by singlet oxygen
(1O2) that forms at all stages of cycling. However, its formation mechanism remains
unclear. We show that disproportionation of superoxide, the product or intermediate
on discharge and charge, to peroxide and oxygen is responsible for 1O2 formation.
While the overall reaction is driven by the stability of peroxide and thus favored
by stronger Lewis acidic cations such as Li+, the 1O2 fraction is enhanced by
weak Lewis acids such as organic cations. Concurrently, the metal peroxide yield
drops with increasing 1O2. The results explain a major parasitic pathway during
cell cycling and the growing severity in K–, Na–, and Li–O2 cells based on the
growing propensity for disproportionation. High capacities and rates with peroxides
are now realized to require solution processes, which form peroxide or release
O2via disproportionation. The results therefore establish the central dilemma
that disproportionation is required for high capacity but also responsible for
irreversible reactions. Highly reversible cell operation requires hence finding
reaction routes that avoid disproportionation.
article_processing_charge: No
article_type: original
author:
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Riccardo
full_name: Spezia, Riccardo
last_name: Spezia
- first_name: Aleksej
full_name: Samojlov, Aleksej
last_name: Samojlov
- first_name: Francesco F.
full_name: Summa, Francesco F.
last_name: Summa
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
- first_name: Sergio
full_name: Brutti, Sergio
last_name: Brutti
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Mourad E, Petit YK, Spezia R, et al. Singlet oxygen from cation driven superoxide
disproportionation and consequences for aprotic metal–O2 batteries. Energy
& Environmental Science. 2019;12(8):2559-2568. doi:10.1039/c9ee01453e
apa: Mourad, E., Petit, Y. K., Spezia, R., Samojlov, A., Summa, F. F., Prehal, C.,
… Freunberger, S. A. (2019). Singlet oxygen from cation driven superoxide disproportionation
and consequences for aprotic metal–O2 batteries. Energy & Environmental
Science. RSC. https://doi.org/10.1039/c9ee01453e
chicago: Mourad, Eléonore, Yann K. Petit, Riccardo Spezia, Aleksej Samojlov, Francesco
F. Summa, Christian Prehal, Christian Leypold, et al. “Singlet Oxygen from Cation
Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.”
Energy & Environmental Science. RSC, 2019. https://doi.org/10.1039/c9ee01453e.
ieee: E. Mourad et al., “Singlet oxygen from cation driven superoxide disproportionation
and consequences for aprotic metal–O2 batteries,” Energy & Environmental
Science, vol. 12, no. 8. RSC, pp. 2559–2568, 2019.
ista: Mourad E, Petit YK, Spezia R, Samojlov A, Summa FF, Prehal C, Leypold C, Mahne
N, Slugovc C, Fontaine O, Brutti S, Freunberger SA. 2019. Singlet oxygen from
cation driven superoxide disproportionation and consequences for aprotic metal–O2
batteries. Energy & Environmental Science. 12(8), 2559–2568.
mla: Mourad, Eléonore, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation
and Consequences for Aprotic Metal–O2 Batteries.” Energy & Environmental
Science, vol. 12, no. 8, RSC, 2019, pp. 2559–68, doi:10.1039/c9ee01453e.
short: E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C.
Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy
& Environmental Science 12 (2019) 2559–2568.
date_created: 2020-01-15T07:18:04Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:12:41Z
day: '01'
ddc:
- '530'
- '541'
- '540'
doi: 10.1039/c9ee01453e
extern: '1'
file:
- access_level: open_access
checksum: 94d4cfb2ab0b4c90ef76a7f3cc811feb
content_type: application/pdf
creator: dernst
date_created: 2020-01-30T16:11:05Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7424'
file_name: 2019_EnergyEnvironScienc_Mourad.pdf
file_size: 2888027
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 2559-2568
publication: Energy & Environmental Science
publication_identifier:
issn:
- 1754-5692
- 1754-5706
publication_status: published
publisher: RSC
quality_controlled: '1'
status: public
title: Singlet oxygen from cation driven superoxide disproportionation and consequences
for aprotic metal–O2 batteries
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...
---
_id: '7280'
abstract:
- lang: eng
text: Non-aqueous lithium-oxygen batteries cycle by forming lithium peroxide during
discharge and oxidizing it during recharge. The significant problem of oxidizing
the solid insulating lithium peroxide can greatly be facilitated by incorporating
redox mediators that shuttle electron-holes between the porous substrate and lithium
peroxide. Redox mediator stability is thus key for energy efficiency, reversibility,
and cycle life. However, the gradual deactivation of redox mediators during repeated
cycling has not conclusively been explained. Here, we show that organic redox
mediators are predominantly decomposed by singlet oxygen that forms during cycling.
Their reaction with superoxide, previously assumed to mainly trigger their degradation,
peroxide, and dioxygen, is orders of magnitude slower in comparison. The reduced
form of the mediator is markedly more reactive towards singlet oxygen than the
oxidized form, from which we derive reaction mechanisms supported by density functional
theory calculations. Redox mediators must thus be designed for stability against
singlet oxygen.
article_number: '1380'
article_processing_charge: No
article_type: original
author:
- first_name: Won-Jin
full_name: Kwak, Won-Jin
last_name: Kwak
- first_name: Hun
full_name: Kim, Hun
last_name: Kim
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Trung Thien
full_name: Nguyen, Trung Thien
last_name: Nguyen
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Paul
full_name: Redfern, Paul
last_name: Redfern
- first_name: Larry A.
full_name: Curtiss, Larry A.
last_name: Curtiss
- first_name: Hun-Gi
full_name: Jung, Hun-Gi
last_name: Jung
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Yang-Kook
full_name: Sun, Yang-Kook
last_name: Sun
citation:
ama: Kwak W-J, Kim H, Petit YK, et al. Deactivation of redox mediators in lithium-oxygen
batteries by singlet oxygen. Nature Communications. 2019;10. doi:10.1038/s41467-019-09399-0
apa: Kwak, W.-J., Kim, H., Petit, Y. K., Leypold, C., Nguyen, T. T., Mahne, N.,
… Sun, Y.-K. (2019). Deactivation of redox mediators in lithium-oxygen batteries
by singlet oxygen. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-019-09399-0
chicago: Kwak, Won-Jin, Hun Kim, Yann K. Petit, Christian Leypold, Trung Thien Nguyen,
Nika Mahne, Paul Redfern, et al. “Deactivation of Redox Mediators in Lithium-Oxygen
Batteries by Singlet Oxygen.” Nature Communications. Springer Nature, 2019.
https://doi.org/10.1038/s41467-019-09399-0.
ieee: W.-J. Kwak et al., “Deactivation of redox mediators in lithium-oxygen
batteries by singlet oxygen,” Nature Communications, vol. 10. Springer
Nature, 2019.
ista: Kwak W-J, Kim H, Petit YK, Leypold C, Nguyen TT, Mahne N, Redfern P, Curtiss
LA, Jung H-G, Borisov SM, Freunberger SA, Sun Y-K. 2019. Deactivation of redox
mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications.
10, 1380.
mla: Kwak, Won-Jin, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries
by Singlet Oxygen.” Nature Communications, vol. 10, 1380, Springer Nature,
2019, doi:10.1038/s41467-019-09399-0.
short: W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern,
L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications
10 (2019).
date_created: 2020-01-15T12:12:26Z
date_published: 2019-03-26T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '26'
ddc:
- '540'
doi: 10.1038/s41467-019-09399-0
extern: '1'
file:
- access_level: open_access
checksum: 123dd33e7f26761c82c74e10811a1e4d
content_type: application/pdf
creator: dernst
date_created: 2020-01-22T15:58:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7355'
file_name: 2019_NatureComm_Kwak.pdf
file_size: 1003676
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 10'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2019'
...
---
_id: '7276'
abstract:
- lang: eng
text: Singlet oxygen (1O2) causes a major fraction of the parasitic chemistry during
the cycling of non‐aqueous alkali metal‐O2 batteries and also contributes to interfacial
reactivity of transition‐metal oxide intercalation compounds. We introduce DABCOnium,
the mono alkylated form of 1,4‐diazabicyclo[2.2.2]octane (DABCO), as an efficient
1O2 quencher with an unusually high oxidative stability of ca. 4.2 V vs. Li/Li+.
Previous quenchers are strongly Lewis basic amines with too low oxidative stability.
DABCOnium is an ionic liquid, non‐volatile, highly soluble in the electrolyte,
stable against superoxide and peroxide, and compatible with lithium metal. The
electrochemical stability covers the required range for metal–O2 batteries and
greatly reduces 1O2 related parasitic chemistry as demonstrated for the Li–O2
cell.
article_processing_charge: No
article_type: original
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Lukas
full_name: Schafzahl, Lukas
last_name: Schafzahl
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: 'Petit YK, Leypold C, Mahne N, et al. DABCOnium: An efficient and high-voltage
stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International
Edition. 2019;58(20):6535-6539. doi:10.1002/anie.201901869'
apa: 'Petit, Y. K., Leypold, C., Mahne, N., Mourad, E., Schafzahl, L., Slugovc,
C., … Freunberger, S. A. (2019). DABCOnium: An efficient and high-voltage stable
singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International
Edition. Wiley. https://doi.org/10.1002/anie.201901869'
chicago: 'Petit, Yann K., Christian Leypold, Nika Mahne, Eléonore Mourad, Lukas
Schafzahl, Christian Slugovc, Sergey M. Borisov, and Stefan Alexander Freunberger.
“DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2
Cells.” Angewandte Chemie International Edition. Wiley, 2019. https://doi.org/10.1002/anie.201901869.'
ieee: 'Y. K. Petit et al., “DABCOnium: An efficient and high-voltage stable
singlet oxygen quencher for metal-O2 cells,” Angewandte Chemie International
Edition, vol. 58, no. 20. Wiley, pp. 6535–6539, 2019.'
ista: 'Petit YK, Leypold C, Mahne N, Mourad E, Schafzahl L, Slugovc C, Borisov SM,
Freunberger SA. 2019. DABCOnium: An efficient and high-voltage stable singlet
oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. 58(20),
6535–6539.'
mla: 'Petit, Yann K., et al. “DABCOnium: An Efficient and High-Voltage Stable Singlet
Oxygen Quencher for Metal-O2 Cells.” Angewandte Chemie International Edition,
vol. 58, no. 20, Wiley, 2019, pp. 6535–39, doi:10.1002/anie.201901869.'
short: Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M.
Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539.
date_created: 2020-01-15T07:19:27Z
date_published: 2019-05-13T00:00:00Z
date_updated: 2021-01-12T08:12:42Z
day: '13'
ddc:
- '540'
doi: 10.1002/anie.201901869
extern: '1'
file:
- access_level: open_access
checksum: 9620b6a511a910d7abe1f26c42dc7f83
content_type: application/pdf
creator: dernst
date_created: 2020-01-22T16:16:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7356'
file_name: 2019_AngewChemie_Petit.pdf
file_size: 952737
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 58'
issue: '20'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 6535-6539
publication: Angewandte Chemie International Edition
publication_identifier:
issn:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for
metal-O2 cells'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2019'
...
---
_id: '7281'
abstract:
- lang: eng
text: Li–O2 batteries are plagued by side reactions that cause poor rechargeability
and efficiency. These reactions were recently revealed to be predominantly caused
by singlet oxygen, which can be neutralized by chemical traps or physical quenchers.
However, traps are irreversibly consumed and thus only active for a limited time,
and so far identified quenchers lack oxidative stability to be suitable for typically
required recharge potentials. Thus, reducing the charge potential within the stability
limit of the quencher and/or finding more stable quenchers is required. Here,
we show that dimethylphenazine as a redox mediator decreases the charge potential
well within the stability limit of the quencher 1,4-diazabicyclo[2.2.2]octane.
The quencher can thus mitigate the parasitic reactions without being oxidatively
decomposed. At the same time the quencher protects the redox mediator from singlet
oxygen attack. The mutual conservation of the redox mediator and the quencher
is rational for stable and effective Li–O2 batteries.
article_processing_charge: No
article_type: original
author:
- first_name: Won-Jin
full_name: Kwak, Won-Jin
last_name: Kwak
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Hun
full_name: Kim, Hun
last_name: Kim
- first_name: Jiwon
full_name: Park, Jiwon
last_name: Park
- first_name: Trung Thien
full_name: Nguyen, Trung Thien
last_name: Nguyen
- first_name: Hun-Gi
full_name: Jung, Hun-Gi
last_name: Jung
- first_name: Hye Ryung
full_name: Byon, Hye Ryung
last_name: Byon
- first_name: Yang-Kook
full_name: Sun, Yang-Kook
last_name: Sun
citation:
ama: Kwak W-J, Freunberger SA, Kim H, et al. Mutual conservation of redox mediator
and singlet oxygen quencher in Lithium–Oxygen batteries. ACS Catalysis.
2019;9(11):9914-9922. doi:10.1021/acscatal.9b01337
apa: Kwak, W.-J., Freunberger, S. A., Kim, H., Park, J., Nguyen, T. T., Jung, H.-G.,
… Sun, Y.-K. (2019). Mutual conservation of redox mediator and singlet oxygen
quencher in Lithium–Oxygen batteries. ACS Catalysis. ACS. https://doi.org/10.1021/acscatal.9b01337
chicago: Kwak, Won-Jin, Stefan Alexander Freunberger, Hun Kim, Jiwon Park, Trung
Thien Nguyen, Hun-Gi Jung, Hye Ryung Byon, and Yang-Kook Sun. “Mutual Conservation
of Redox Mediator and Singlet Oxygen Quencher in Lithium–Oxygen Batteries.” ACS
Catalysis. ACS, 2019. https://doi.org/10.1021/acscatal.9b01337.
ieee: W.-J. Kwak et al., “Mutual conservation of redox mediator and singlet
oxygen quencher in Lithium–Oxygen batteries,” ACS Catalysis, vol. 9, no.
11. ACS, pp. 9914–9922, 2019.
ista: Kwak W-J, Freunberger SA, Kim H, Park J, Nguyen TT, Jung H-G, Byon HR, Sun
Y-K. 2019. Mutual conservation of redox mediator and singlet oxygen quencher in
Lithium–Oxygen batteries. ACS Catalysis. 9(11), 9914–9922.
mla: Kwak, Won-Jin, et al. “Mutual Conservation of Redox Mediator and Singlet Oxygen
Quencher in Lithium–Oxygen Batteries.” ACS Catalysis, vol. 9, no. 11, ACS,
2019, pp. 9914–22, doi:10.1021/acscatal.9b01337.
short: W.-J. Kwak, S.A. Freunberger, H. Kim, J. Park, T.T. Nguyen, H.-G. Jung, H.R.
Byon, Y.-K. Sun, ACS Catalysis 9 (2019) 9914–9922.
date_created: 2020-01-15T12:12:40Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '01'
ddc:
- '540'
doi: 10.1021/acscatal.9b01337
extern: '1'
file:
- access_level: open_access
checksum: bbaebfe5ff0bcab6235821ba3460b7de
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T15:19:30Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8053'
file_name: Revised Manuscript.pdf
file_size: 1199086
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 9'
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 9914-9922
publication: ACS Catalysis
publication_identifier:
issn:
- 2155-5435
publication_status: published
publisher: ACS
quality_controlled: '1'
status: public
title: Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen
batteries
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2019'
...
---
_id: '7282'
abstract:
- lang: eng
text: Interphases that form on the anode surface of lithium-ion batteries are critical
for performance and lifetime, but are poorly understood. Now, a decade-old misconception
regarding a main component of the interphase has been revealed, which could potentially
lead to improved devices.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Freunberger SA. Interphase identity crisis. Nature Chemistry. 2019;11(9):761-763.
doi:10.1038/s41557-019-0311-0
apa: Freunberger, S. A. (2019). Interphase identity crisis. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/s41557-019-0311-0
chicago: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature
Chemistry. Springer Nature, 2019. https://doi.org/10.1038/s41557-019-0311-0.
ieee: S. A. Freunberger, “Interphase identity crisis,” Nature Chemistry,
vol. 11, no. 9. Springer Nature, pp. 761–763, 2019.
ista: Freunberger SA. 2019. Interphase identity crisis. Nature Chemistry. 11(9),
761–763.
mla: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature Chemistry,
vol. 11, no. 9, Springer Nature, 2019, pp. 761–63, doi:10.1038/s41557-019-0311-0.
short: S.A. Freunberger, Nature Chemistry 11 (2019) 761–763.
date_created: 2020-01-15T12:12:53Z
date_published: 2019-08-19T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '19'
ddc:
- '540'
- '547'
doi: 10.1038/s41557-019-0311-0
extern: '1'
file:
- access_level: open_access
checksum: 76806cff3d5b62f846499a8617cee7ef
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T15:38:21Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8054'
file_name: Freunberger on Eichhorn.pdf
file_size: 286805
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '9'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 761-763
publication: Nature Chemistry
publication_identifier:
issn:
- 1755-4330
- 1755-4349
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Interphase identity crisis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...
---
_id: '7283'
abstract:
- lang: eng
text: Potassium–air batteries, which suffer from oxygen cathode and potassium metal
anode degradation, can be cycled thousands of times when an organic anode replaces
the metal.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Petit YK, Freunberger SA. Thousands of cycles. Nature Materials. 2019;18(4):301-302.
doi:10.1038/s41563-019-0313-8
apa: Petit, Y. K., & Freunberger, S. A. (2019). Thousands of cycles. Nature
Materials. Springer Nature. https://doi.org/10.1038/s41563-019-0313-8
chicago: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.”
Nature Materials. Springer Nature, 2019. https://doi.org/10.1038/s41563-019-0313-8.
ieee: Y. K. Petit and S. A. Freunberger, “Thousands of cycles,” Nature Materials,
vol. 18, no. 4. Springer Nature, pp. 301–302, 2019.
ista: Petit YK, Freunberger SA. 2019. Thousands of cycles. Nature Materials. 18(4),
301–302.
mla: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.” Nature
Materials, vol. 18, no. 4, Springer Nature, 2019, pp. 301–02, doi:10.1038/s41563-019-0313-8.
short: Y.K. Petit, S.A. Freunberger, Nature Materials 18 (2019) 301–302.
date_created: 2020-01-15T12:13:05Z
date_published: 2019-03-20T00:00:00Z
date_updated: 2021-01-12T08:12:45Z
day: '20'
ddc:
- '540'
- '541'
doi: 10.1038/s41563-019-0313-8
extern: '1'
file:
- access_level: open_access
checksum: 4c9a0314327028a22dd902bc109b8798
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T16:26:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8059'
file_name: NaV_final.pdf
file_size: 398123
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 18'
issue: '4'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 301-302
publication: Nature Materials
publication_identifier:
issn:
- 1476-1122
- 1476-4660
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Thousands of cycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2019'
...
---
_id: '7284'
abstract:
- lang: eng
text: In this issue of Joule, Dongmin Im and coworkers from Samsung in South Korea
describe a prototype lithium-O2 battery that reaches ∼700 Wh kg–1 and ∼600 Wh
L–1 on the cell level. They cut all components to the minimum to reach this value.
Difficulties filling the pores with discharge product and inhomogeneous cell utilization
turn out to limit the achievable energy. Their work underlines the importance
of reporting performance with respect to full cell weight and volume.
article_processing_charge: No
article_type: review
author:
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Prehal C, Freunberger SA. Li-O2 cell-scale energy densities. Joule.
2019;3(2):321-323. doi:10.1016/j.joule.2019.01.020
apa: Prehal, C., & Freunberger, S. A. (2019). Li-O2 cell-scale energy densities.
Joule. Elsevier. https://doi.org/10.1016/j.joule.2019.01.020
chicago: Prehal, Christian, and Stefan Alexander Freunberger. “Li-O2 Cell-Scale
Energy Densities.” Joule. Elsevier, 2019. https://doi.org/10.1016/j.joule.2019.01.020.
ieee: C. Prehal and S. A. Freunberger, “Li-O2 cell-scale energy densities,” Joule,
vol. 3, no. 2. Elsevier, pp. 321–323, 2019.
ista: Prehal C, Freunberger SA. 2019. Li-O2 cell-scale energy densities. Joule.
3(2), 321–323.
mla: Prehal, Christian, and Stefan Alexander Freunberger. “Li-O2 Cell-Scale Energy
Densities.” Joule, vol. 3, no. 2, Elsevier, 2019, pp. 321–23, doi:10.1016/j.joule.2019.01.020.
short: C. Prehal, S.A. Freunberger, Joule 3 (2019) 321–323.
date_created: 2020-01-15T12:13:15Z
date_published: 2019-02-20T00:00:00Z
date_updated: 2021-01-12T08:12:45Z
day: '20'
doi: 10.1016/j.joule.2019.01.020
extern: '1'
intvolume: ' 3'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.1016/j.joule.2019.01.020
month: '02'
oa: 1
oa_version: Published Version
page: 321-323
publication: Joule
publication_identifier:
issn:
- 2542-4351
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Li-O2 cell-scale energy densities
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2019'
...
---
_id: '7358'
abstract:
- lang: eng
text: Telencephalic organoids generated from human pluripotent stem cells (hPSCs)
are emerging as an effective system to study the distinct features of the developing
human brain and the underlying causes of many neurological disorders. While progress
in organoid technology has been steadily advancing, many challenges remain including
rampant batch-to-batch and cell line-to-cell line variability and irreproducibility.
Here, we demonstrate that a major contributor to successful cortical organoid
production is the manner in which hPSCs are maintained prior to differentiation.
Optimal results were achieved using fibroblast-feeder-supported hPSCs compared
to feeder-independent cells, related to differences in their transcriptomic states.
Feeder-supported hPSCs display elevated activation of diverse TGFβ superfamily
signaling pathways and increased expression of genes associated with naïve pluripotency.
We further identify combinations of TGFβ-related growth factors that are necessary
and together sufficient to impart broad telencephalic organoid competency to feeder-free
hPSCs and enable reproducible formation of brain structures suitable for disease
modeling.
article_processing_charge: No
author:
- first_name: Momoko
full_name: Watanabe, Momoko
last_name: Watanabe
- first_name: Jillian R.
full_name: Haney, Jillian R.
last_name: Haney
- first_name: Neda
full_name: Vishlaghi, Neda
last_name: Vishlaghi
- first_name: Felix
full_name: Turcios, Felix
last_name: Turcios
- first_name: Jessie E.
full_name: Buth, Jessie E.
last_name: Buth
- first_name: Wen
full_name: Gu, Wen
last_name: Gu
- first_name: Amanda J.
full_name: Collier, Amanda J.
last_name: Collier
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Di
full_name: Chen, Di
last_name: Chen
- first_name: Shan
full_name: Sabri, Shan
last_name: Sabri
- first_name: Amander T.
full_name: Clark, Amander T.
last_name: Clark
- first_name: Kathrin
full_name: Plath, Kathrin
last_name: Plath
- first_name: Heather R.
full_name: Christofk, Heather R.
last_name: Christofk
- first_name: Michael J.
full_name: Gandal, Michael J.
last_name: Gandal
- first_name: Bennett G.
full_name: Novitch, Bennett G.
last_name: Novitch
citation:
ama: Watanabe M, Haney JR, Vishlaghi N, et al. TGFβ superfamily signaling regulates
the state of human stem cell pluripotency and competency to create telencephalic
organoids. bioRxiv. 2019. doi:10.1101/2019.12.13.875773
apa: Watanabe, M., Haney, J. R., Vishlaghi, N., Turcios, F., Buth, J. E., Gu, W.,
… Novitch, B. G. (2019). TGFβ superfamily signaling regulates the state of human
stem cell pluripotency and competency to create telencephalic organoids. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2019.12.13.875773
chicago: Watanabe, Momoko, Jillian R. Haney, Neda Vishlaghi, Felix Turcios, Jessie
E. Buth, Wen Gu, Amanda J. Collier, et al. “TGFβ Superfamily Signaling Regulates
the State of Human Stem Cell Pluripotency and Competency to Create Telencephalic
Organoids.” BioRxiv. Cold Spring Harbor Laboratory, 2019. https://doi.org/10.1101/2019.12.13.875773.
ieee: M. Watanabe et al., “TGFβ superfamily signaling regulates the state
of human stem cell pluripotency and competency to create telencephalic organoids,”
bioRxiv. Cold Spring Harbor Laboratory, 2019.
ista: Watanabe M, Haney JR, Vishlaghi N, Turcios F, Buth JE, Gu W, Collier AJ, Miranda
O, Chen D, Sabri S, Clark AT, Plath K, Christofk HR, Gandal MJ, Novitch BG. 2019.
TGFβ superfamily signaling regulates the state of human stem cell pluripotency
and competency to create telencephalic organoids. bioRxiv, 10.1101/2019.12.13.875773.
mla: Watanabe, Momoko, et al. “TGFβ Superfamily Signaling Regulates the State of
Human Stem Cell Pluripotency and Competency to Create Telencephalic Organoids.”
BioRxiv, Cold Spring Harbor Laboratory, 2019, doi:10.1101/2019.12.13.875773.
short: M. Watanabe, J.R. Haney, N. Vishlaghi, F. Turcios, J.E. Buth, W. Gu, A.J.
Collier, O. Miranda, D. Chen, S. Sabri, A.T. Clark, K. Plath, H.R. Christofk,
M.J. Gandal, B.G. Novitch, BioRxiv (2019).
date_created: 2020-01-23T09:53:40Z
date_published: 2019-12-13T00:00:00Z
date_updated: 2022-06-17T08:03:32Z
day: '13'
doi: 10.1101/2019.12.13.875773
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2019.12.13.875773
month: '12'
oa: 1
oa_version: Preprint
page: '75'
publication: bioRxiv
publication_status: published
publisher: Cold Spring Harbor Laboratory
status: public
title: TGFβ superfamily signaling regulates the state of human stem cell pluripotency
and competency to create telencephalic organoids
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '7401'
abstract:
- lang: eng
text: 'The genus g(G) of a graph G is the minimum g such that G has an embedding
on the orientable surface M_g of genus g. A drawing of a graph on a surface is
independently even if every pair of nonadjacent edges in the drawing crosses an
even number of times. The Z_2-genus of a graph G, denoted by g_0(G), is the minimum
g such that G has an independently even drawing on M_g. By a result of Battle,
Harary, Kodama and Youngs from 1962, the graph genus is additive over 2-connected
blocks. In 2013, Schaefer and Stefankovic proved that the Z_2-genus of a graph
is additive over 2-connected blocks as well, and asked whether this result can
be extended to so-called 2-amalgamations, as an analogue of results by Decker,
Glover, Huneke, and Stahl for the genus. We give the following partial answer.
If G=G_1 cup G_2, G_1 and G_2 intersect in two vertices u and v, and G-u-v has
k connected components (among which we count the edge uv if present), then |g_0(G)-(g_0(G_1)+g_0(G_2))|<=k+1.
For complete bipartite graphs K_{m,n}, with n >= m >= 3, we prove that g_0(K_{m,n})/g(K_{m,n})=1-O(1/n).
Similar results are proved also for the Euler Z_2-genus. We express the Z_2-genus
of a graph using the minimum rank of partial symmetric matrices over Z_2; a problem
that might be of independent interest. '
alternative_title:
- LIPIcs
article_number: '39'
article_processing_charge: No
author:
- first_name: Radoslav
full_name: Fulek, Radoslav
id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
last_name: Fulek
orcid: 0000-0001-8485-1774
- first_name: Jan
full_name: Kyncl, Jan
last_name: Kyncl
citation:
ama: 'Fulek R, Kyncl J. Z_2-Genus of graphs and minimum rank of partial symmetric
matrices. In: 35th International Symposium on Computational Geometry (SoCG
2019). Vol 129. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2019. doi:10.4230/LIPICS.SOCG.2019.39'
apa: 'Fulek, R., & Kyncl, J. (2019). Z_2-Genus of graphs and minimum rank of
partial symmetric matrices. In 35th International Symposium on Computational
Geometry (SoCG 2019) (Vol. 129). Portland, OR, United States: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPICS.SOCG.2019.39'
chicago: Fulek, Radoslav, and Jan Kyncl. “Z_2-Genus of Graphs and Minimum Rank of
Partial Symmetric Matrices.” In 35th International Symposium on Computational
Geometry (SoCG 2019), Vol. 129. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2019. https://doi.org/10.4230/LIPICS.SOCG.2019.39.
ieee: R. Fulek and J. Kyncl, “Z_2-Genus of graphs and minimum rank of partial symmetric
matrices,” in 35th International Symposium on Computational Geometry (SoCG
2019), Portland, OR, United States, 2019, vol. 129.
ista: 'Fulek R, Kyncl J. 2019. Z_2-Genus of graphs and minimum rank of partial symmetric
matrices. 35th International Symposium on Computational Geometry (SoCG 2019).
SoCG: Symposium on Computational Geometry, LIPIcs, vol. 129, 39.'
mla: Fulek, Radoslav, and Jan Kyncl. “Z_2-Genus of Graphs and Minimum Rank of Partial
Symmetric Matrices.” 35th International Symposium on Computational Geometry
(SoCG 2019), vol. 129, 39, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2019, doi:10.4230/LIPICS.SOCG.2019.39.
short: R. Fulek, J. Kyncl, in:, 35th International Symposium on Computational Geometry
(SoCG 2019), Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019.
conference:
end_date: 2019-06-21
location: Portland, OR, United States
name: 'SoCG: Symposium on Computational Geometry'
start_date: 2019-06-18
date_created: 2020-01-29T16:17:05Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2021-01-12T08:13:24Z
day: '01'
ddc:
- '000'
department:
- _id: UlWa
doi: 10.4230/LIPICS.SOCG.2019.39
external_id:
arxiv:
- '1903.08637'
file:
- access_level: open_access
checksum: aac37b09118cc0ab58cf77129e691f8c
content_type: application/pdf
creator: dernst
date_created: 2020-02-04T09:14:31Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7445'
file_name: 2019_LIPIcs_Fulek.pdf
file_size: 628347
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
intvolume: ' 129'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 261FA626-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02281
name: Eliminating intersections in drawings of graphs
publication: 35th International Symposium on Computational Geometry (SoCG 2019)
publication_identifier:
isbn:
- 978-3-95977-104-7
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: 1
status: public
title: Z_2-Genus of graphs and minimum rank of partial symmetric matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 129
year: '2019'
...
---
_id: '7453'
abstract:
- lang: eng
text: We illustrate the ingredients of the state-of-the-art of model-based approach
for the formal design and verification of cyber-physical systems. To capture the
interaction between a discrete controller and its continuously evolving environment,
we use the formal models of timed and hybrid automata. We explain the steps of
modeling and verification in the tools Uppaal and SpaceEx using a case study based
on a dual-chamber implantable pacemaker monitoring a human heart. We show how
to design a model as a composition of components, how to construct models at varying
levels of detail, how to establish that one model is an abstraction of another,
how to specify correctness requirements using temporal logic, and how to verify
that a model satisfies a logical requirement.
acknowledgement: This research was supported in part by the Austrian Science Fund
(FWF) under grants S11402-N23(RiSE/SHiNE) and Z211-N23 (Wittgenstein Award). This
research has received funding from the Sino-Danish Basic Research Centre, IDEA4CPS,
funded by the Danish National Research Foundation and the National Science Foundation,
China, the Innovation Fund Denmark centre DiCyPS, as well as the ERC Advanced Grant
LASSO.
alternative_title:
- Lecture Notes in Computer Science
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Mirco
full_name: Giacobbe, Mirco
id: 3444EA5E-F248-11E8-B48F-1D18A9856A87
last_name: Giacobbe
orcid: 0000-0001-8180-0904
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Kim G.
full_name: Larsen, Kim G.
last_name: Larsen
- first_name: Marius
full_name: Mikučionis, Marius
last_name: Mikučionis
citation:
ama: 'Alur R, Giacobbe M, Henzinger TA, Larsen KG, Mikučionis M. Continuous-time
models for system design and analysis. In: Steffen B, Woeginger G, eds. Computing
and Software Science. Vol 10000. LNCS. Springer Nature; 2019:452-477. doi:10.1007/978-3-319-91908-9_22'
apa: Alur, R., Giacobbe, M., Henzinger, T. A., Larsen, K. G., & Mikučionis,
M. (2019). Continuous-time models for system design and analysis. In B. Steffen
& G. Woeginger (Eds.), Computing and Software Science (Vol. 10000,
pp. 452–477). Springer Nature. https://doi.org/10.1007/978-3-319-91908-9_22
chicago: Alur, Rajeev, Mirco Giacobbe, Thomas A Henzinger, Kim G. Larsen, and Marius
Mikučionis. “Continuous-Time Models for System Design and Analysis.” In Computing
and Software Science, edited by Bernhard Steffen and Gerhard Woeginger, 10000:452–77.
LNCS. Springer Nature, 2019. https://doi.org/10.1007/978-3-319-91908-9_22.
ieee: R. Alur, M. Giacobbe, T. A. Henzinger, K. G. Larsen, and M. Mikučionis, “Continuous-time
models for system design and analysis,” in Computing and Software Science,
vol. 10000, B. Steffen and G. Woeginger, Eds. Springer Nature, 2019, pp. 452–477.
ista: 'Alur R, Giacobbe M, Henzinger TA, Larsen KG, Mikučionis M. 2019.Continuous-time
models for system design and analysis. In: Computing and Software Science. Lecture
Notes in Computer Science, vol. 10000, 452–477.'
mla: Alur, Rajeev, et al. “Continuous-Time Models for System Design and Analysis.”
Computing and Software Science, edited by Bernhard Steffen and Gerhard
Woeginger, vol. 10000, Springer Nature, 2019, pp. 452–77, doi:10.1007/978-3-319-91908-9_22.
short: R. Alur, M. Giacobbe, T.A. Henzinger, K.G. Larsen, M. Mikučionis, in:, B.
Steffen, G. Woeginger (Eds.), Computing and Software Science, Springer Nature,
2019, pp. 452–477.
date_created: 2020-02-05T10:51:44Z
date_published: 2019-10-05T00:00:00Z
date_updated: 2022-09-06T08:25:52Z
day: '05'
department:
- _id: ToHe
doi: 10.1007/978-3-319-91908-9_22
editor:
- first_name: Bernhard
full_name: Steffen, Bernhard
last_name: Steffen
- first_name: Gerhard
full_name: Woeginger, Gerhard
last_name: Woeginger
intvolume: ' 10000'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1007/978-3-319-91908-9_22
month: '10'
oa: 1
oa_version: Published Version
page: 452-477
project:
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Computing and Software Science
publication_identifier:
eisbn:
- '9783319919089'
eissn:
- 0302-9743
isbn:
- '9783319919072'
issn:
- 1611-3349
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: Continuous-time models for system design and analysis
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10000
year: '2019'
...
---
_id: '7459'
abstract:
- lang: eng
text: We report the fabrication of BaTiO3-Ni magnetoelectric nanocomposites comprising
of BaTiO3 nanotubes surrounded by Ni matrix. BaTiO3 nanotubes obtained from the
hydrothermal transformation of TiO2 have both inner and outer surfaces, which
facilitates greater magnetoelectric coupling with the surrounding Ni matrix. The
magnetoelectric coupling was studied by measuring the piezoelectric behavior in
the presence of an in-plane direct magnetic field. A higher magnetoelectric voltage
coefficient of 110 mV/cm·Oe was obtained, because of better coupling between Ni
and BaTiO3 through the walls of the nanotubes. Such nanocomposite developed directly
on Ti substrate may lead to efficient fabrication of magnetoelectric devices.
article_processing_charge: No
article_type: original
author:
- first_name: Samba Siva
full_name: Vadla, Samba Siva
last_name: Vadla
- first_name: Tommaso
full_name: Costanzo, Tommaso
id: D93824F4-D9BA-11E9-BB12-F207E6697425
last_name: Costanzo
orcid: 0000-0001-9732-3815
- first_name: Subish
full_name: John, Subish
last_name: John
- first_name: Gabriel
full_name: Caruntu, Gabriel
last_name: Caruntu
- first_name: Somnath C.
full_name: Roy, Somnath C.
last_name: Roy
citation:
ama: Vadla SS, Costanzo T, John S, Caruntu G, Roy SC. Local probing of magnetoelectric
coupling in BaTiO3-Ni 1–3 composites. Scripta Materialia. 2019;159:33-36.
doi:10.1016/j.scriptamat.2018.09.003
apa: Vadla, S. S., Costanzo, T., John, S., Caruntu, G., & Roy, S. C. (2019).
Local probing of magnetoelectric coupling in BaTiO3-Ni 1–3 composites. Scripta
Materialia. Elsevier. https://doi.org/10.1016/j.scriptamat.2018.09.003
chicago: Vadla, Samba Siva, Tommaso Costanzo, Subish John, Gabriel Caruntu, and
Somnath C. Roy. “Local Probing of Magnetoelectric Coupling in BaTiO3-Ni 1–3 Composites.”
Scripta Materialia. Elsevier, 2019. https://doi.org/10.1016/j.scriptamat.2018.09.003.
ieee: S. S. Vadla, T. Costanzo, S. John, G. Caruntu, and S. C. Roy, “Local probing
of magnetoelectric coupling in BaTiO3-Ni 1–3 composites,” Scripta Materialia,
vol. 159. Elsevier, pp. 33–36, 2019.
ista: Vadla SS, Costanzo T, John S, Caruntu G, Roy SC. 2019. Local probing of magnetoelectric
coupling in BaTiO3-Ni 1–3 composites. Scripta Materialia. 159, 33–36.
mla: Vadla, Samba Siva, et al. “Local Probing of Magnetoelectric Coupling in BaTiO3-Ni
1–3 Composites.” Scripta Materialia, vol. 159, Elsevier, 2019, pp. 33–36,
doi:10.1016/j.scriptamat.2018.09.003.
short: S.S. Vadla, T. Costanzo, S. John, G. Caruntu, S.C. Roy, Scripta Materialia
159 (2019) 33–36.
date_created: 2020-02-05T14:19:17Z
date_published: 2019-01-15T00:00:00Z
date_updated: 2023-02-23T13:08:31Z
day: '15'
doi: 10.1016/j.scriptamat.2018.09.003
extern: '1'
intvolume: ' 159'
language:
- iso: eng
month: '01'
oa_version: None
page: 33-36
publication: Scripta Materialia
publication_identifier:
issn:
- 1359-6462
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Local probing of magnetoelectric coupling in BaTiO3-Ni 1–3 composites
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 159
year: '2019'
...
---
_id: '7476'
abstract:
- lang: eng
text: The sebaceous gland (SG) is an essential component of the skin, and SG dysfunction
is debilitating1,2. Yet, the cellular bases for its origin, development and subsequent
maintenance remain poorly understood. Here, we apply large-scale quantitative
fate mapping to define the patterns of cell fate behaviour during SG development
and maintenance. We show that the SG develops from a defined number of lineage-restricted
progenitors that undergo a programme of independent and stochastic cell fate decisions.
Following an expansion phase, equipotent progenitors transition into a phase of
homeostatic turnover, which is correlated with changes in the mechanical properties
of the stroma and spatial restrictions on gland size. Expression of the oncogene
KrasG12D results in a release from these constraints and unbridled gland expansion.
Quantitative clonal fate analysis reveals that, during this phase, the primary
effect of the Kras oncogene is to drive a constant fate bias with little effect
on cell division rates. These findings provide insight into the developmental
programme of the SG, as well as the mechanisms that drive tumour progression and
gland dysfunction.
article_processing_charge: No
article_type: original
author:
- first_name: Marianne Stemann
full_name: Andersen, Marianne Stemann
last_name: Andersen
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Svetlana
full_name: Ulyanchenko, Svetlana
last_name: Ulyanchenko
- first_name: Soline
full_name: Estrach, Soline
last_name: Estrach
- first_name: Yasuko
full_name: Antoku, Yasuko
last_name: Antoku
- first_name: Sabrina
full_name: Pisano, Sabrina
last_name: Pisano
- first_name: Kim E.
full_name: Boonekamp, Kim E.
last_name: Boonekamp
- first_name: Sarah
full_name: Sendrup, Sarah
last_name: Sendrup
- first_name: Martti
full_name: Maimets, Martti
last_name: Maimets
- first_name: Marianne Terndrup
full_name: Pedersen, Marianne Terndrup
last_name: Pedersen
- first_name: Jens V.
full_name: Johansen, Jens V.
last_name: Johansen
- first_name: Ditte L.
full_name: Clement, Ditte L.
last_name: Clement
- first_name: Chloe C.
full_name: Feral, Chloe C.
last_name: Feral
- first_name: Benjamin D.
full_name: Simons, Benjamin D.
last_name: Simons
- first_name: Kim B.
full_name: Jensen, Kim B.
last_name: Jensen
citation:
ama: Andersen MS, Hannezo EB, Ulyanchenko S, et al. Tracing the cellular dynamics
of sebaceous gland development in normal and perturbed states. Nature Cell
Biology. 2019;21(8):924-932. doi:10.1038/s41556-019-0362-x
apa: Andersen, M. S., Hannezo, E. B., Ulyanchenko, S., Estrach, S., Antoku, Y.,
Pisano, S., … Jensen, K. B. (2019). Tracing the cellular dynamics of sebaceous
gland development in normal and perturbed states. Nature Cell Biology.
Springer Nature. https://doi.org/10.1038/s41556-019-0362-x
chicago: Andersen, Marianne Stemann, Edouard B Hannezo, Svetlana Ulyanchenko, Soline
Estrach, Yasuko Antoku, Sabrina Pisano, Kim E. Boonekamp, et al. “Tracing the
Cellular Dynamics of Sebaceous Gland Development in Normal and Perturbed States.”
Nature Cell Biology. Springer Nature, 2019. https://doi.org/10.1038/s41556-019-0362-x.
ieee: M. S. Andersen et al., “Tracing the cellular dynamics of sebaceous
gland development in normal and perturbed states,” Nature Cell Biology,
vol. 21, no. 8. Springer Nature, pp. 924–932, 2019.
ista: Andersen MS, Hannezo EB, Ulyanchenko S, Estrach S, Antoku Y, Pisano S, Boonekamp
KE, Sendrup S, Maimets M, Pedersen MT, Johansen JV, Clement DL, Feral CC, Simons
BD, Jensen KB. 2019. Tracing the cellular dynamics of sebaceous gland development
in normal and perturbed states. Nature Cell Biology. 21(8), 924–932.
mla: Andersen, Marianne Stemann, et al. “Tracing the Cellular Dynamics of Sebaceous
Gland Development in Normal and Perturbed States.” Nature Cell Biology,
vol. 21, no. 8, Springer Nature, 2019, pp. 924–32, doi:10.1038/s41556-019-0362-x.
short: M.S. Andersen, E.B. Hannezo, S. Ulyanchenko, S. Estrach, Y. Antoku, S. Pisano,
K.E. Boonekamp, S. Sendrup, M. Maimets, M.T. Pedersen, J.V. Johansen, D.L. Clement,
C.C. Feral, B.D. Simons, K.B. Jensen, Nature Cell Biology 21 (2019) 924–932.
date_created: 2020-02-11T08:43:49Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:13:47Z
day: '01'
doi: 10.1038/s41556-019-0362-x
extern: '1'
external_id:
pmid:
- '31358966'
intvolume: ' 21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978139/
month: '08'
oa: 1
oa_version: Submitted Version
page: 924-932
pmid: 1
publication: Nature Cell Biology
publication_identifier:
issn:
- 1465-7392
- 1476-4679
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Tracing the cellular dynamics of sebaceous gland development in normal and
perturbed states
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2019'
...
---
_id: '7548'
abstract:
- lang: eng
text: Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils
is a well-established hallmark of Alzheimer’s disease, the complex mechanisms
linking this process to neurodegeneration are still incompletely understood. The
nematode worm C. elegans is a valuable model organism through which to study these
mechanisms because of its simple nervous system and its relatively short lifespan.
Standard Aβ-based C. elegans models of Alzheimer’s disease are designed to study
the toxic effects of the overexpression of Aβ in the muscle or nervous systems.
However, the wide variety of effects associated with the tissue-level overexpression
of Aβ makes it difficult to single out and study specific cellular mechanisms
related to the onset of Alzheimer’s disease. Here, to better understand how to
investigate the early events affecting neuronal signalling, we created a C. elegans
model expressing Aβ42, the 42-residue form of Aβ, from a single-copy gene insertion
in just one pair of glutamatergic sensory neurons, the BAG neurons. In behavioural
assays, we found that the Aβ42-expressing animals displayed a subtle modulation
of the response to CO2, compared to controls. Ca2+ imaging revealed that the BAG
neurons in young Aβ42-expressing nematodes were activated more strongly than in
control animals, and that neuronal activation remained intact until old age. Taken
together, our results suggest that Aβ42-expression in this very subtle model of
AD is sufficient to modulate the behavioural response but not strong enough to
generate significant neurotoxicity, suggesting that slightly more aggressive perturbations
will enable effectively studies of the links between the modulation of a physiological
response and its associated neurotoxicity.
article_number: e0217746
article_processing_charge: No
article_type: original
author:
- first_name: Tessa
full_name: Sinnige, Tessa
last_name: Sinnige
- first_name: Prashanth
full_name: Ciryam, Prashanth
last_name: Ciryam
- first_name: Samuel
full_name: Casford, Samuel
last_name: Casford
- first_name: Christopher M.
full_name: Dobson, Christopher M.
last_name: Dobson
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
citation:
ama: Sinnige T, Ciryam P, Casford S, Dobson CM, de Bono M, Vendruscolo M. Expression
of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates
the associated behavioural response. PLOS ONE. 2019;14(5). doi:10.1371/journal.pone.0217746
apa: Sinnige, T., Ciryam, P., Casford, S., Dobson, C. M., de Bono, M., & Vendruscolo,
M. (2019). Expression of the amyloid-β peptide in a single pair of C. elegans
sensory neurons modulates the associated behavioural response. PLOS ONE.
Public Library of Science. https://doi.org/10.1371/journal.pone.0217746
chicago: Sinnige, Tessa, Prashanth Ciryam, Samuel Casford, Christopher M. Dobson,
Mario de Bono, and Michele Vendruscolo. “Expression of the Amyloid-β Peptide in
a Single Pair of C. Elegans Sensory Neurons Modulates the Associated Behavioural
Response.” PLOS ONE. Public Library of Science, 2019. https://doi.org/10.1371/journal.pone.0217746.
ieee: T. Sinnige, P. Ciryam, S. Casford, C. M. Dobson, M. de Bono, and M. Vendruscolo,
“Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons
modulates the associated behavioural response,” PLOS ONE, vol. 14, no.
5. Public Library of Science, 2019.
ista: Sinnige T, Ciryam P, Casford S, Dobson CM, de Bono M, Vendruscolo M. 2019.
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons
modulates the associated behavioural response. PLOS ONE. 14(5), e0217746.
mla: Sinnige, Tessa, et al. “Expression of the Amyloid-β Peptide in a Single Pair
of C. Elegans Sensory Neurons Modulates the Associated Behavioural Response.”
PLOS ONE, vol. 14, no. 5, e0217746, Public Library of Science, 2019, doi:10.1371/journal.pone.0217746.
short: T. Sinnige, P. Ciryam, S. Casford, C.M. Dobson, M. de Bono, M. Vendruscolo,
PLOS ONE 14 (2019).
date_created: 2020-02-28T10:45:13Z
date_published: 2019-05-31T00:00:00Z
date_updated: 2021-01-12T08:14:08Z
day: '31'
doi: 10.1371/journal.pone.0217746
extern: '1'
intvolume: ' 14'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: Published Version
publication: PLOS ONE
publication_identifier:
issn:
- 1932-6203
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
status: public
title: Expression of the amyloid-β peptide in a single pair of C. elegans sensory
neurons modulates the associated behavioural response
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2019'
...
---
_id: '7547'
abstract:
- lang: eng
text: The BH3-only family of proteins is key for initiating apoptosis in a variety
of contexts, and may also contribute to non-apoptotic cellular processes. Historically,
the nematode Caenorhabditis elegans has provided a powerful system for studying
and identifying conserved regulators of BH3-only proteins. In C. elegans, the
BH3-only protein egl-1 is expressed during development to cell-autonomously trigger
most developmental cell deaths. Here we provide evidence that egl-1 is also transcribed
after development in the sensory neuron pair URX without inducing apoptosis. We
used genetic screening and epistasis analysis to determine that its transcription
is regulated in URX by neuronal activity and/or in parallel by orthologs of Protein
Kinase G and the Salt-Inducible Kinase family. Because several BH3-only family
proteins are also expressed in the adult nervous system of mammals, we suggest
that studying egl-1 expression in URX may shed light on mechanisms that regulate
conserved family members in higher organisms.
article_processing_charge: No
article_type: original
author:
- first_name: Jesse
full_name: Cohn, Jesse
last_name: Cohn
- first_name: Vivek
full_name: Dwivedi, Vivek
last_name: Dwivedi
- first_name: Giulio
full_name: Valperga, Giulio
last_name: Valperga
- first_name: Nicole
full_name: Zarate, Nicole
last_name: Zarate
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: H. Robert
full_name: Horvitz, H. Robert
last_name: Horvitz
- first_name: Jonathan T.
full_name: Pierce, Jonathan T.
last_name: Pierce
citation:
ama: 'Cohn J, Dwivedi V, Valperga G, et al. Activity-dependent regulation of the
proapoptotic BH3-only gene egl-1 in a living neuron pair in Caenorhabditis elegans.
G3: Genes, Genomes, Genetics. 2019;9(11):3703-3714. doi:10.1534/g3.119.400654'
apa: 'Cohn, J., Dwivedi, V., Valperga, G., Zarate, N., de Bono, M., Horvitz, H.
R., & Pierce, J. T. (2019). Activity-dependent regulation of the proapoptotic
BH3-only gene egl-1 in a living neuron pair in Caenorhabditis elegans. G3:
Genes, Genomes, Genetics. Genetics Society of America. https://doi.org/10.1534/g3.119.400654'
chicago: 'Cohn, Jesse, Vivek Dwivedi, Giulio Valperga, Nicole Zarate, Mario de Bono,
H. Robert Horvitz, and Jonathan T. Pierce. “Activity-Dependent Regulation of the
Proapoptotic BH3-Only Gene Egl-1 in a Living Neuron Pair in Caenorhabditis Elegans.”
G3: Genes, Genomes, Genetics. Genetics Society of America, 2019. https://doi.org/10.1534/g3.119.400654.'
ieee: 'J. Cohn et al., “Activity-dependent regulation of the proapoptotic
BH3-only gene egl-1 in a living neuron pair in Caenorhabditis elegans,” G3:
Genes, Genomes, Genetics, vol. 9, no. 11. Genetics Society of America, pp.
3703–3714, 2019.'
ista: 'Cohn J, Dwivedi V, Valperga G, Zarate N, de Bono M, Horvitz HR, Pierce JT.
2019. Activity-dependent regulation of the proapoptotic BH3-only gene egl-1 in
a living neuron pair in Caenorhabditis elegans. G3: Genes, Genomes, Genetics.
9(11), 3703–3714.'
mla: 'Cohn, Jesse, et al. “Activity-Dependent Regulation of the Proapoptotic BH3-Only
Gene Egl-1 in a Living Neuron Pair in Caenorhabditis Elegans.” G3: Genes, Genomes,
Genetics, vol. 9, no. 11, Genetics Society of America, 2019, pp. 3703–14,
doi:10.1534/g3.119.400654.'
short: 'J. Cohn, V. Dwivedi, G. Valperga, N. Zarate, M. de Bono, H.R. Horvitz, J.T.
Pierce, G3: Genes, Genomes, Genetics 9 (2019) 3703–3714.'
date_created: 2020-02-28T10:44:27Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2021-01-12T08:14:07Z
day: '01'
doi: 10.1534/g3.119.400654
extern: '1'
external_id:
pmid:
- '31519744'
intvolume: ' 9'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: Published Version
page: 3703-3714
pmid: 1
publication: 'G3: Genes, Genomes, Genetics'
publication_identifier:
issn:
- 2160-1836
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: Activity-dependent regulation of the proapoptotic BH3-only gene egl-1 in a
living neuron pair in Caenorhabditis elegans
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2019'
...
---
_id: '7550'
abstract:
- lang: eng
text: 'We consider an optimal control problem for an abstract nonlinear dissipative
evolution equation. The differential constraint is penalized by augmenting the
target functional by a nonnegative global-in-time functional which is null-minimized
in the evolution equation is satisfied. Different variational settings are presented,
leading to the convergence of the penalization method for gradient flows, noncyclic
and semimonotone flows, doubly nonlinear evolutions, and GENERIC systems. '
acknowledgement: This work is supported by Vienna Science and Technology Fund (WWTF)
through Project MA14-009 and by the Austrian Science Fund (FWF) projects F 65 and
I 2375.
article_processing_charge: No
article_type: original
author:
- first_name: Lorenzo
full_name: Portinale, Lorenzo
id: 30AD2CBC-F248-11E8-B48F-1D18A9856A87
last_name: Portinale
- first_name: Ulisse
full_name: Stefanelli, Ulisse
last_name: Stefanelli
citation:
ama: Portinale L, Stefanelli U. Penalization via global functionals of optimal-control
problems for dissipative evolution. Advances in Mathematical Sciences and Applications.
2019;28(2):425-447.
apa: Portinale, L., & Stefanelli, U. (2019). Penalization via global functionals
of optimal-control problems for dissipative evolution. Advances in Mathematical
Sciences and Applications. Gakko Tosho.
chicago: Portinale, Lorenzo, and Ulisse Stefanelli. “Penalization via Global Functionals
of Optimal-Control Problems for Dissipative Evolution.” Advances in Mathematical
Sciences and Applications. Gakko Tosho, 2019.
ieee: L. Portinale and U. Stefanelli, “Penalization via global functionals of optimal-control
problems for dissipative evolution,” Advances in Mathematical Sciences and
Applications, vol. 28, no. 2. Gakko Tosho, pp. 425–447, 2019.
ista: Portinale L, Stefanelli U. 2019. Penalization via global functionals of optimal-control
problems for dissipative evolution. Advances in Mathematical Sciences and Applications.
28(2), 425–447.
mla: Portinale, Lorenzo, and Ulisse Stefanelli. “Penalization via Global Functionals
of Optimal-Control Problems for Dissipative Evolution.” Advances in Mathematical
Sciences and Applications, vol. 28, no. 2, Gakko Tosho, 2019, pp. 425–47.
short: L. Portinale, U. Stefanelli, Advances in Mathematical Sciences and Applications
28 (2019) 425–447.
date_created: 2020-02-28T10:54:41Z
date_published: 2019-10-22T00:00:00Z
date_updated: 2022-06-17T07:52:41Z
day: '22'
department:
- _id: JaMa
external_id:
arxiv:
- '1910.10050'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.1910.10050'
month: '10'
oa: 1
oa_version: Preprint
page: 425-447
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
publication: Advances in Mathematical Sciences and Applications
publication_identifier:
issn:
- 1343-4373
publication_status: published
publisher: Gakko Tosho
quality_controlled: '1'
status: public
title: Penalization via global functionals of optimal-control problems for dissipative
evolution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2019'
...
---
_id: '7552'
abstract:
- lang: eng
text: 'There is increasing evidence that protein binding to specific sites along
DNA can activate the reading out of genetic information without coming into direct
physical contact with the gene. There also is evidence that these distant but
interacting sites are embedded in a liquid droplet of proteins which condenses
out of the surrounding solution. We argue that droplet-mediated interactions can
account for crucial features of gene regulation only if the droplet is poised
at a non-generic point in its phase diagram. We explore a minimal model that embodies
this idea, show that this model has a natural mechanism for self-tuning, and suggest
direct experimental tests. '
article_processing_charge: No
author:
- first_name: William
full_name: Bialek, William
last_name: Bialek
- first_name: Thomas
full_name: Gregor, Thomas
last_name: Gregor
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Bialek W, Gregor T, Tkačik G. Action at a distance in transcriptional regulation.
arXiv:191208579.
apa: Bialek, W., Gregor, T., & Tkačik, G. (n.d.). Action at a distance in transcriptional
regulation. arXiv:1912.08579. ArXiv.
chicago: Bialek, William, Thomas Gregor, and Gašper Tkačik. “Action at a Distance
in Transcriptional Regulation.” ArXiv:1912.08579. ArXiv, n.d.
ieee: W. Bialek, T. Gregor, and G. Tkačik, “Action at a distance in transcriptional
regulation,” arXiv:1912.08579. ArXiv.
ista: Bialek W, Gregor T, Tkačik G. Action at a distance in transcriptional regulation.
arXiv:1912.08579, .
mla: Bialek, William, et al. “Action at a Distance in Transcriptional Regulation.”
ArXiv:1912.08579, ArXiv.
short: W. Bialek, T. Gregor, G. Tkačik, ArXiv:1912.08579 (n.d.).
date_created: 2020-02-28T10:57:08Z
date_published: 2019-12-18T00:00:00Z
date_updated: 2021-01-12T08:14:09Z
day: '18'
department:
- _id: GaTk
external_id:
arxiv:
- '1912.08579'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.08579
month: '12'
oa: 1
oa_version: Preprint
page: '5'
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: arXiv:1912.08579
publication_status: submitted
publisher: ArXiv
status: public
title: Action at a distance in transcriptional regulation
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...