---
_id: '1781'
abstract:
- lang: eng
text: Microwave cavities with high quality factors enable coherent coupling of distant
quantum systems. Virtual photons lead to a transverse interaction between qubits
when they are nonresonant with the cavity but resonant with each other. We experimentally
investigate the inverse scaling of the interqubit coupling with the detuning from
a cavity mode and its proportionality to the qubit-cavity interaction strength.
We demonstrate that the enhanced coupling at higher frequencies is mediated by
multiple higher-harmonic cavity modes. Moreover, we observe dark states of the
coupled qubit-qubit system and analyze their relation to the symmetry of the applied
driving field at different frequencies.
acknowledgement: This work was supported by the Swiss National Science Foundation
(SNF), the Austrian Science Foundation (FWF), and ETH Zurich
author:
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: M
full_name: Göppl, M
last_name: Göppl
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: R
full_name: Bianchetti, R
last_name: Bianchetti
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Filipp S, Göppl M, Fink JM, et al. Multimode mediated qubit-qubit coupling
and dark-state symmetries in circuit quantum electrodynamics. Physical Review
A - Atomic, Molecular, and Optical Physics. 2011;83(6). doi:10.1103/PhysRevA.83.063827
apa: Filipp, S., Göppl, M., Fink, J. M., Baur, M., Bianchetti, R., Steffen, L.,
& Wallraff, A. (2011). Multimode mediated qubit-qubit coupling and dark-state
symmetries in circuit quantum electrodynamics. Physical Review A - Atomic,
Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.83.063827
chicago: Filipp, Stefan, M Göppl, Johannes M Fink, Matthias Baur, R Bianchetti,
L. Steffen, and Andreas Wallraff. “Multimode Mediated Qubit-Qubit Coupling and
Dark-State Symmetries in Circuit Quantum Electrodynamics.” Physical Review
A - Atomic, Molecular, and Optical Physics. American Physical Society, 2011.
https://doi.org/10.1103/PhysRevA.83.063827.
ieee: S. Filipp et al., “Multimode mediated qubit-qubit coupling and dark-state
symmetries in circuit quantum electrodynamics,” Physical Review A - Atomic,
Molecular, and Optical Physics, vol. 83, no. 6. American Physical Society,
2011.
ista: Filipp S, Göppl M, Fink JM, Baur M, Bianchetti R, Steffen L, Wallraff A. 2011.
Multimode mediated qubit-qubit coupling and dark-state symmetries in circuit quantum
electrodynamics. Physical Review A - Atomic, Molecular, and Optical Physics. 83(6).
mla: Filipp, Stefan, et al. “Multimode Mediated Qubit-Qubit Coupling and Dark-State
Symmetries in Circuit Quantum Electrodynamics.” Physical Review A - Atomic,
Molecular, and Optical Physics, vol. 83, no. 6, American Physical Society,
2011, doi:10.1103/PhysRevA.83.063827.
short: S. Filipp, M. Göppl, J.M. Fink, M. Baur, R. Bianchetti, L. Steffen, A. Wallraff,
Physical Review A - Atomic, Molecular, and Optical Physics 83 (2011).
date_created: 2018-12-11T11:53:58Z
date_published: 2011-06-22T00:00:00Z
date_updated: 2021-01-12T06:53:09Z
day: '22'
doi: 10.1103/PhysRevA.83.063827
extern: 1
intvolume: ' 83'
issue: '6'
month: '06'
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_status: published
publisher: American Physical Society
publist_id: '5335'
quality_controlled: 0
status: public
title: Multimode mediated qubit-qubit coupling and dark-state symmetries in circuit
quantum electrodynamics
type: journal_article
volume: 83
year: '2011'
...
---
_id: '1780'
abstract:
- lang: eng
text: Continuous variable entanglement between two modes of a radiation field is
usually studied at optical frequencies. Here we demonstrate experiments that show
the entanglement between microwave photons of different energy in a broadband
squeezed beam. We use a Josephson parametric amplifier to generate the two-mode
correlated state and detect all four quadrature components simultaneously in a
two-channel heterodyne setup using amplitude detectors. Analyzing two-dimensional
phase space histograms for all possible pairs of quadratures allows us to determine
the full covariance matrix, which is in good agreement with the one expected for
a two-mode squeezed state.
acknowledgement: This work was supported by the European Research Council (ERC) through
a Starting grant and by ETHZ. S. F. acknowledges the Austrian Science Foundation
(FWF) for support
author:
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Eichler C, Bozyigit D, Lang C, et al. Observation of two-mode squeezing in
the microwave frequency domain. Physical Review Letters. 2011;107(11).
doi:10.1103/PhysRevLett.107.113601
apa: Eichler, C., Bozyigit, D., Lang, C., Baur, M., Steffen, L., Fink, J. M., …
Wallraff, A. (2011). Observation of two-mode squeezing in the microwave frequency
domain. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.107.113601
chicago: Eichler, Christopher, Deniz Bozyigit, C Lang, Matthias Baur, L. Steffen,
Johannes M Fink, Stefan Filipp, and Andreas Wallraff. “Observation of Two-Mode
Squeezing in the Microwave Frequency Domain.” Physical Review Letters.
American Physical Society, 2011. https://doi.org/10.1103/PhysRevLett.107.113601.
ieee: C. Eichler et al., “Observation of two-mode squeezing in the microwave
frequency domain,” Physical Review Letters, vol. 107, no. 11. American
Physical Society, 2011.
ista: Eichler C, Bozyigit D, Lang C, Baur M, Steffen L, Fink JM, Filipp S, Wallraff
A. 2011. Observation of two-mode squeezing in the microwave frequency domain.
Physical Review Letters. 107(11).
mla: Eichler, Christopher, et al. “Observation of Two-Mode Squeezing in the Microwave
Frequency Domain.” Physical Review Letters, vol. 107, no. 11, American
Physical Society, 2011, doi:10.1103/PhysRevLett.107.113601.
short: C. Eichler, D. Bozyigit, C. Lang, M. Baur, L. Steffen, J.M. Fink, S. Filipp,
A. Wallraff, Physical Review Letters 107 (2011).
date_created: 2018-12-11T11:53:58Z
date_published: 2011-09-06T00:00:00Z
date_updated: 2021-01-12T06:53:09Z
day: '06'
doi: 10.1103/PhysRevLett.107.113601
extern: 1
intvolume: ' 107'
issue: '11'
month: '09'
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5334'
quality_controlled: 0
status: public
title: Observation of two-mode squeezing in the microwave frequency domain
type: journal_article
volume: 107
year: '2011'
...
---
_id: '1815'
abstract:
- lang: eng
text: Many membrane channels and receptors exhibit adaptive, or desensitized, response
to a strong sustained input stimulus, often supported by protein activity-dependent
inactivation. Adaptive response is thought to be related to various cellular functions
such as homeostasis and enlargement of dynamic range by background compensation.
Here we study the quantitative relation between adaptive response and background
compensation within a modeling framework. We show that any particular type of
adaptive response is neither sufficient nor necessary for adaptive enlargement
of dynamic range. In particular a precise adaptive response, where system activity
is maintained at a constant level at steady state, does not ensure a large dynamic
range neither in input signal nor in system output. A general mechanism for input
dynamic range enlargement can come about from the activity-dependent modulation
of protein responsiveness by multiple biochemical modification, regardless of
the type of adaptive response it induces. Therefore hierarchical biochemical processes
such as methylation and phosphorylation are natural candidates to induce this
property in signaling systems.
author:
- first_name: Tamar
full_name: Tamar Friedlander
id: 36A5845C-F248-11E8-B48F-1D18A9856A87
last_name: Friedlander
- first_name: Naama
full_name: Brenner, Naama
last_name: Brenner
citation:
ama: Friedlander T, Brenner N. Adaptive response and enlargement of dynamic range.
Mathematical Biosciences and Engineering. 2011;8(2):515-526. doi:10.3934/mbe.2011.8.515
apa: Friedlander, T., & Brenner, N. (2011). Adaptive response and enlargement
of dynamic range. Mathematical Biosciences and Engineering. Arizona State
University. https://doi.org/10.3934/mbe.2011.8.515
chicago: Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement
of Dynamic Range.” Mathematical Biosciences and Engineering. Arizona State
University, 2011. https://doi.org/10.3934/mbe.2011.8.515.
ieee: T. Friedlander and N. Brenner, “Adaptive response and enlargement of dynamic
range,” Mathematical Biosciences and Engineering, vol. 8, no. 2. Arizona
State University, pp. 515–526, 2011.
ista: Friedlander T, Brenner N. 2011. Adaptive response and enlargement of dynamic
range. Mathematical Biosciences and Engineering. 8(2), 515–526.
mla: Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement of
Dynamic Range.” Mathematical Biosciences and Engineering, vol. 8, no. 2,
Arizona State University, 2011, pp. 515–26, doi:10.3934/mbe.2011.8.515.
short: T. Friedlander, N. Brenner, Mathematical Biosciences and Engineering 8 (2011)
515–526.
date_created: 2018-12-11T11:54:10Z
date_published: 2011-04-02T00:00:00Z
date_updated: 2021-01-12T06:53:23Z
day: '02'
doi: 10.3934/mbe.2011.8.515
extern: 1
intvolume: ' 8'
issue: '2'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1003.2791
month: '04'
oa: 1
page: 515 - 526
publication: Mathematical Biosciences and Engineering
publication_status: published
publisher: Arizona State University
publist_id: '5291'
quality_controlled: 0
status: public
title: Adaptive response and enlargement of dynamic range
type: journal_article
volume: 8
year: '2011'
...
---
_id: '1863'
abstract:
- lang: eng
text: The Levene model is the simplest mathematical model to describe the evolution
of gene frequencies in spatially subdivided populations. It provides insight into
how locally varying selection promotes a population’s genetic diversity. Despite
its simplicity, interesting problems have remained unsolved even in the diallelic
case. In this paper we answer an open problem by establishing that for two alleles
at one locus and J demes, up to 2J−1 polymorphic equilibria may coexist. We first
present a proof for the case of stable monomorphisms and then show that the result
also holds for protected alleles. These findings allow us to prove that any odd
number (up to 2J−1) of equilibria is possible, before we extend the proof to even
numbers. We conclude with some numerical results and show that for J>2, the
proportion of parameter space affording this maximum is extremely small.
acknowledgement: FWF 21305
author:
- first_name: Sebastian
full_name: Sebastian Novak
id: 461468AE-F248-11E8-B48F-1D18A9856A87
last_name: Novak
citation:
ama: Novak S. The number of equilibria in the diallelic Levene model with multiple
demes. Theoretical Population Biology. 2011;79(3):97-101. doi:10.1016/j.tpb.2010.12.002
apa: Novak, S. (2011). The number of equilibria in the diallelic Levene model with
multiple demes. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/j.tpb.2010.12.002
chicago: Novak, Sebastian. “The Number of Equilibria in the Diallelic Levene Model
with Multiple Demes.” Theoretical Population Biology. Academic Press, 2011.
https://doi.org/10.1016/j.tpb.2010.12.002.
ieee: S. Novak, “The number of equilibria in the diallelic Levene model with multiple
demes,” Theoretical Population Biology, vol. 79, no. 3. Academic Press,
pp. 97–101, 2011.
ista: Novak S. 2011. The number of equilibria in the diallelic Levene model with
multiple demes. Theoretical Population Biology. 79(3), 97–101.
mla: Novak, Sebastian. “The Number of Equilibria in the Diallelic Levene Model with
Multiple Demes.” Theoretical Population Biology, vol. 79, no. 3, Academic
Press, 2011, pp. 97–101, doi:10.1016/j.tpb.2010.12.002.
short: S. Novak, Theoretical Population Biology 79 (2011) 97–101.
date_created: 2018-12-11T11:54:25Z
date_published: 2011-05-01T00:00:00Z
date_updated: 2021-01-12T06:53:42Z
day: '01'
doi: 10.1016/j.tpb.2010.12.002
extern: 1
intvolume: ' 79'
issue: '3'
month: '05'
page: 97 - 101
publication: Theoretical Population Biology
publication_status: published
publisher: Academic Press
publist_id: '5236'
quality_controlled: 0
status: public
title: The number of equilibria in the diallelic Levene model with multiple demes
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
volume: 79
year: '2011'
...
---
_id: '1975'
abstract:
- lang: eng
text: 'Modern α-proteobacteria are thought to be closely related to the ancient
symbiont of eukaryotes, an ancestor of mitochondria. Respiratory complex I from
α-proteobacteria and mitochondria is well conserved at the level of the 14 "core"
subunits, consistent with that notion. Mitochondrial complex I contains the core
subunits, present in all species, and up to 31 "supernumerary" subunits,
generally thought to have originated only within eukaryotic lineages. However,
the full protein composition of an α-proteobacterial complex I has not been established
previously. Here, we report the first purification and characterization of complex
I from the α-proteobacterium Paracoccus denitrificans. Single particle electron
microscopy shows that the complex has a well defined L-shape. Unexpectedly, in
addition to the 14 core subunits, the enzyme also contains homologues of three
supernumerary mitochondrial subunits as follows: B17.2, AQDQ/18, and 13 kDa (bovine
nomenclature). This finding suggests that evolution of complex I via addition
of supernumerary or "accessory" subunits started before the original
endosymbiotic event that led to the creation of the eukaryotic cell. It also provides
further confirmation that α-proteobacteria are the closest extant relatives of
mitochondria.'
acknowledgement: 'This work was supported by the Medical Research Council. '
author:
- first_name: Chui
full_name: Yip, Chui Y
last_name: Yip
- first_name: Michael
full_name: Harbour, Michael E
last_name: Harbour
- first_name: Kamburapola
full_name: Jayawardena, Kamburapola G
last_name: Jayawardena
- first_name: Ian
full_name: Fearnley, Ian M
last_name: Fearnley
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. Evolution of respiratory
complex I "Supernumerary" subunits are present in the α-proteobacterial
enzyme. Journal of Biological Chemistry. 2011;286(7):5023-5033. doi:10.1074/jbc.M110.194993
apa: Yip, C., Harbour, M., Jayawardena, K., Fearnley, I., & Sazanov, L. A. (2011).
Evolution of respiratory complex I "Supernumerary" subunits
are present in the α-proteobacterial enzyme. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M110.194993
chicago: Yip, Chui, Michael Harbour, Kamburapola Jayawardena, Ian Fearnley, and
Leonid A Sazanov. “Evolution of Respiratory Complex I "Supernumerary"
Subunits Are Present in the α-Proteobacterial Enzyme.” Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology, 2011.
https://doi.org/10.1074/jbc.M110.194993.
ieee: C. Yip, M. Harbour, K. Jayawardena, I. Fearnley, and L. A. Sazanov, “Evolution
of respiratory complex I "Supernumerary" subunits are present
in the α-proteobacterial enzyme,” Journal of Biological Chemistry, vol.
286, no. 7. American Society for Biochemistry and Molecular Biology, pp. 5023–5033,
2011.
ista: Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. 2011. Evolution of
respiratory complex I "Supernumerary" subunits are present in
the α-proteobacterial enzyme. Journal of Biological Chemistry. 286(7), 5023–5033.
mla: Yip, Chui, et al. “Evolution of Respiratory Complex I "Supernumerary"
Subunits Are Present in the α-Proteobacterial Enzyme.” Journal of Biological
Chemistry, vol. 286, no. 7, American Society for Biochemistry and Molecular
Biology, 2011, pp. 5023–33, doi:10.1074/jbc.M110.194993.
short: C. Yip, M. Harbour, K. Jayawardena, I. Fearnley, L.A. Sazanov, Journal of
Biological Chemistry 286 (2011) 5023–5033.
date_created: 2018-12-11T11:55:00Z
date_published: 2011-02-18T00:00:00Z
date_updated: 2021-01-12T06:54:27Z
day: '18'
doi: 10.1074/jbc.M110.194993
extern: 1
intvolume: ' 286'
issue: '7'
month: '02'
page: 5023 - 5033
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '5112'
quality_controlled: 0
status: public
title: Evolution of respiratory complex I "Supernumerary" subunits are present
in the α-proteobacterial enzyme
type: journal_article
volume: 286
year: '2011'
...
---
_id: '1973'
abstract:
- lang: eng
text: Complex I is the first and largest enzyme of the respiratory chain, coupling
electron transfer between NADH and ubiquinone to the translocation of four protons
across the membrane. It has a central role in cellular energy production and has
been implicated in many human neurodegenerative diseases. The L-shaped enzyme
consists of hydrophilic and membrane domains. Previously, we determined the structure
of the hydrophilic domain. Here we report the crystal structure of the Esherichia
coli complex I membrane domain at 3.0 Ã. resolution. It includes six subunits,
NuoL, NuoM, NuoN, NuoA, NuoJ and NuoK, with 55 transmembrane helices. The fold
of the homologous antiporter-like subunits L, M and N is novel, with two inverted
structural repeats of five transmembrane helices arranged, unusually, face-to-back.
Each repeat includes a discontinuous transmembrane helix and forms half of a channel
across the membrane. A network of conserved polar residues connects the two half-channels,
completing the proton translocation pathway. Unexpectedly, lysines rather than
carboxylate residues act as the main elements of the proton pump in these subunits.
The fourth probable proton-translocation channel is at the interface of subunits
N, K, J and A. The structure indicates that proton translocation in complex I,
uniquely, involves coordinated conformational changes in six symmetrical structural
elements.
acknowledgement: This work was funded by the Medical Research Council.
author:
- first_name: Rouslan
full_name: Efremov, Rouslan G
last_name: Efremov
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Efremov R, Sazanov LA. Structure of the membrane domain of respiratory complex
i. Nature. 2011;476(7361):414-421. doi:10.1038/nature10330
apa: Efremov, R., & Sazanov, L. A. (2011). Structure of the membrane domain
of respiratory complex i. Nature. Nature Publishing Group. https://doi.org/10.1038/nature10330
chicago: Efremov, Rouslan, and Leonid A Sazanov. “Structure of the Membrane Domain
of Respiratory Complex I.” Nature. Nature Publishing Group, 2011. https://doi.org/10.1038/nature10330.
ieee: R. Efremov and L. A. Sazanov, “Structure of the membrane domain of respiratory
complex i,” Nature, vol. 476, no. 7361. Nature Publishing Group, pp. 414–421,
2011.
ista: Efremov R, Sazanov LA. 2011. Structure of the membrane domain of respiratory
complex i. Nature. 476(7361), 414–421.
mla: Efremov, Rouslan, and Leonid A. Sazanov. “Structure of the Membrane Domain
of Respiratory Complex I.” Nature, vol. 476, no. 7361, Nature Publishing
Group, 2011, pp. 414–21, doi:10.1038/nature10330.
short: R. Efremov, L.A. Sazanov, Nature 476 (2011) 414–421.
date_created: 2018-12-11T11:54:59Z
date_published: 2011-08-25T00:00:00Z
date_updated: 2021-01-12T06:54:26Z
day: '25'
doi: 10.1038/nature10330
extern: 1
intvolume: ' 476'
issue: '7361'
month: '08'
page: 414 - 421
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '5110'
quality_controlled: 0
status: public
title: Structure of the membrane domain of respiratory complex i
type: journal_article
volume: 476
year: '2011'
...
---
_id: '1974'
abstract:
- lang: eng
text: Complex I is the first enzyme of the respiratory chain and plays a central
role in cellular energy production. It has been implicated in many human neurodegenerative
diseases, as well as in ageing. One of the biggest membrane protein complexes,
it is an L-shaped assembly consisting of hydrophilic and membrane domains. Previously,
we have determined structures of the hydrophilic domain in several redox states.
Last year was marked by fascinating breakthroughs in the understanding of the
complete structure. We described the architecture of the membrane domain and of
the entire bacterial complex I. X-ray analysis of the larger mitochondrial enzyme
has also been published. The core subunits of the bacterial and mitochondrial
enzymes have remarkably similar structures. The proposed mechanism of coupling
between electron transfer and proton translocation involves long-range conformational
changes, coordinated in part by a long α-helix, akin to the coupling rod of a
steam engine.
acknowledgement: The work in authors’ laboratory was funded by the Medical Research
Council.
author:
- first_name: Rouslan
full_name: Efremov, Rouslan G
last_name: Efremov
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: 'Efremov R, Sazanov LA. Respiratory complex I: “steam engine” of the cell?
Current Opinion in Structural Biology. 2011;21(4):532-540. doi:10.1016/j.sbi.2011.07.002'
apa: 'Efremov, R., & Sazanov, L. A. (2011). Respiratory complex I: “steam engine”
of the cell? Current Opinion in Structural Biology. Elsevier. https://doi.org/10.1016/j.sbi.2011.07.002'
chicago: 'Efremov, Rouslan, and Leonid A Sazanov. “Respiratory Complex I: ‘steam
Engine’ of the Cell?” Current Opinion in Structural Biology. Elsevier,
2011. https://doi.org/10.1016/j.sbi.2011.07.002.'
ieee: 'R. Efremov and L. A. Sazanov, “Respiratory complex I: ‘steam engine’ of the
cell?,” Current Opinion in Structural Biology, vol. 21, no. 4. Elsevier,
pp. 532–540, 2011.'
ista: 'Efremov R, Sazanov LA. 2011. Respiratory complex I: ‘steam engine’ of the
cell? Current Opinion in Structural Biology. 21(4), 532–540.'
mla: 'Efremov, Rouslan, and Leonid A. Sazanov. “Respiratory Complex I: ‘steam Engine’
of the Cell?” Current Opinion in Structural Biology, vol. 21, no. 4, Elsevier,
2011, pp. 532–40, doi:10.1016/j.sbi.2011.07.002.'
short: R. Efremov, L.A. Sazanov, Current Opinion in Structural Biology 21 (2011)
532–540.
date_created: 2018-12-11T11:54:59Z
date_published: 2011-08-01T00:00:00Z
date_updated: 2021-01-12T06:54:27Z
day: '01'
doi: 10.1016/j.sbi.2011.07.002
extern: 1
intvolume: ' 21'
issue: '4'
month: '08'
page: 532 - 540
publication: Current Opinion in Structural Biology
publication_status: published
publisher: Elsevier
publist_id: '5111'
quality_controlled: 0
status: public
title: 'Respiratory complex I: ''steam engine'' of the cell?'
type: journal_article
volume: 21
year: '2011'
...
---
_id: '1985'
abstract:
- lang: eng
text: |2-
In Escherichia coli, the pole-to-pole oscillation of the Min proteins directs septum formation to midcell, which is required for symmetric cell division. In vitro, protein waves emerge from the self-organization of MinD, a membrane-binding ATPase, and its activator MinE. For wave propagation, the proteins need to cycle through states of collective membrane binding and unbinding. Although MinD presumably undergoes cooperative membrane attachment, it is unclear how synchronous detachment is coordinated. We used confocal and single-molecule microscopy to elucidate the order of events during Min wave propagation. We propose that protein detachment at the rear of the wave, and the formation of the E-ring, are accomplished by two complementary processes: first, local accumulation of MinE due to rapid rebinding, leading to dynamic instability; and second, a structural change induced by membrane-interaction of MinE in an equimolar MinD-MinE (MinDE) complex, which supports the robustness of pattern formation.
acknowledgement: This work was also supported by the Max Planck Society (M.L., E.F.-F.,
P.S.).
author:
- first_name: Martin
full_name: Martin Loose
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Elisabeth
full_name: Fischer-Friedrich, Elisabeth
last_name: Fischer Friedrich
- first_name: Christoph
full_name: Herold, Christoph
last_name: Herold
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Petra
full_name: 'Schwille, Petra '
last_name: Schwille
citation:
ama: Loose M, Fischer Friedrich E, Herold C, Kruse K, Schwille P. Min protein patterns
emerge from rapid rebinding and membrane interaction of MinE. Nature Structural
and Molecular Biology. 2011;18(5):577-583. doi:10.1038/nsmb.2037
apa: Loose, M., Fischer Friedrich, E., Herold, C., Kruse, K., & Schwille, P.
(2011). Min protein patterns emerge from rapid rebinding and membrane interaction
of MinE. Nature Structural and Molecular Biology. Nature Publishing Group.
https://doi.org/10.1038/nsmb.2037
chicago: Loose, Martin, Elisabeth Fischer Friedrich, Christoph Herold, Karsten Kruse,
and Petra Schwille. “Min Protein Patterns Emerge from Rapid Rebinding and Membrane
Interaction of MinE.” Nature Structural and Molecular Biology. Nature Publishing
Group, 2011. https://doi.org/10.1038/nsmb.2037.
ieee: M. Loose, E. Fischer Friedrich, C. Herold, K. Kruse, and P. Schwille, “Min
protein patterns emerge from rapid rebinding and membrane interaction of MinE,”
Nature Structural and Molecular Biology, vol. 18, no. 5. Nature Publishing
Group, pp. 577–583, 2011.
ista: Loose M, Fischer Friedrich E, Herold C, Kruse K, Schwille P. 2011. Min protein
patterns emerge from rapid rebinding and membrane interaction of MinE. Nature
Structural and Molecular Biology. 18(5), 577–583.
mla: Loose, Martin, et al. “Min Protein Patterns Emerge from Rapid Rebinding and
Membrane Interaction of MinE.” Nature Structural and Molecular Biology,
vol. 18, no. 5, Nature Publishing Group, 2011, pp. 577–83, doi:10.1038/nsmb.2037.
short: M. Loose, E. Fischer Friedrich, C. Herold, K. Kruse, P. Schwille, Nature
Structural and Molecular Biology 18 (2011) 577–583.
date_created: 2018-12-11T11:55:03Z
date_published: 2011-05-01T00:00:00Z
date_updated: 2021-01-12T06:54:31Z
day: '01'
doi: 10.1038/nsmb.2037
extern: 1
intvolume: ' 18'
issue: '5'
month: '05'
page: 577 - 583
publication: Nature Structural and Molecular Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5098'
quality_controlled: 0
status: public
title: Min protein patterns emerge from rapid rebinding and membrane interaction of
MinE
type: journal_article
volume: 18
year: '2011'
...
---
_id: '1986'
abstract:
- lang: eng
text: One of the most fundamental features of biological systems is probably their
ability to self-organize in space and time on different scales. Despite many elaborate
theoretical models of how molecular self-organization can come about, only a few
experimental systems of biological origin have so far been rigorously described,
due mostly to their inherent complexity. The most promising strategy of modern
biophysics is thus to identify minimal biological systems showing self-organized
emergent behavior. One of the best-understood examples of protein self-organization,
which has recently been successfully reconstituted in vitro, is represented by
the oscillations of the Min proteins in Escherichia coli. In this review, we summarize
the current understanding of the mechanism of Min protein self-organization in
vivo and in vitro. We discuss the potential of the Min oscillations to sense the
geometry of the cell and suggest that spontaneous protein waves could be a general
means of intracellular organization. We hypothesize that cooperative membrane
binding and unbinding, e.g., as an energy-dependent switch, may act as an important
regulatory mechanism for protein oscillations and pattern formation in the cell.
author:
- first_name: Martin
full_name: Martin Loose
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Petra
full_name: 'Schwille, Petra '
last_name: Schwille
citation:
ama: 'Loose M, Kruse K, Schwille P. Protein self-organization: Lessons from the
min system. Annual Review of Biophysics. 2011;40(1):315-336. doi:10.1146/annurev-biophys-042910-155332'
apa: 'Loose, M., Kruse, K., & Schwille, P. (2011). Protein self-organization:
Lessons from the min system. Annual Review of Biophysics. Annual Reviews.
https://doi.org/10.1146/annurev-biophys-042910-155332'
chicago: 'Loose, Martin, Karsten Kruse, and Petra Schwille. “Protein Self-Organization:
Lessons from the Min System.” Annual Review of Biophysics. Annual Reviews,
2011. https://doi.org/10.1146/annurev-biophys-042910-155332.'
ieee: 'M. Loose, K. Kruse, and P. Schwille, “Protein self-organization: Lessons
from the min system,” Annual Review of Biophysics, vol. 40, no. 1. Annual
Reviews, pp. 315–336, 2011.'
ista: 'Loose M, Kruse K, Schwille P. 2011. Protein self-organization: Lessons from
the min system. Annual Review of Biophysics. 40(1), 315–336.'
mla: 'Loose, Martin, et al. “Protein Self-Organization: Lessons from the Min System.”
Annual Review of Biophysics, vol. 40, no. 1, Annual Reviews, 2011, pp.
315–36, doi:10.1146/annurev-biophys-042910-155332.'
short: M. Loose, K. Kruse, P. Schwille, Annual Review of Biophysics 40 (2011) 315–336.
date_created: 2018-12-11T11:55:04Z
date_published: 2011-06-09T00:00:00Z
date_updated: 2021-01-12T06:54:31Z
day: '09'
doi: 10.1146/annurev-biophys-042910-155332
extern: 1
intvolume: ' 40'
issue: '1'
month: '06'
page: 315 - 336
publication: Annual Review of Biophysics
publication_status: published
publisher: Annual Reviews
publist_id: '5097'
quality_controlled: 0
status: public
title: 'Protein self-organization: Lessons from the min system'
type: journal_article
volume: 40
year: '2011'
...
---
_id: '2072'
abstract:
- lang: eng
text: Many species have morphologically and genetically differentiated sex chromosomes,
such as the XY pair of mammals. Y chromosomes are often highly degenerated and
carry few functional genes, so that XY males have only one copy of most Xlinked
genes (whereas females have two). As a result, chromosome-wide mechanisms of dosage
compensation, such as the mammalian X-inactivation, often evolve to reestablish
expression balance. A similar phenomenon is expected in femaleheterogametic species,
where ZW females should suffer from imbalances due to W-chromosome degeneration.
However, no global dosage compensation mechanisms have been detected in the two
independent ZW systems that have been studied systematically (birds and silkworm),
leading to the suggestion that lack of global dosage compensation may be a general
feature of female-heterogametic species. However, analyses of other independently
evolved ZW systems are required to test if this is the case. In this study, we
use published genomic and expression data to test for the presence of global dosage
compensation in Schistosoma mansoni, a trematode parasite that causes schistosomiasis
in humans. We find that Z-linked expression is reduced relative to autosomal expression
in females but not males, consistent with incomplete or localized dosage compensation.
This gives further support to the theory that female-heterogametic species may
not require global mechanisms of dosage compensation.
author:
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Doris
full_name: Bachtrog, Doris
last_name: Bachtrog
citation:
ama: Vicoso B, Bachtrog D. Lack of global dosage compensation in Schistosoma mansoni,
a female-heterogametic parasite. Genome Biology and Evolution. 2011;3(1):230-235.
doi:10.1093/gbe/evr010
apa: Vicoso, B., & Bachtrog, D. (2011). Lack of global dosage compensation in
Schistosoma mansoni, a female-heterogametic parasite. Genome Biology and Evolution.
Oxford University Press. https://doi.org/10.1093/gbe/evr010
chicago: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation
in Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and
Evolution. Oxford University Press, 2011. https://doi.org/10.1093/gbe/evr010.
ieee: B. Vicoso and D. Bachtrog, “Lack of global dosage compensation in Schistosoma
mansoni, a female-heterogametic parasite,” Genome Biology and Evolution,
vol. 3, no. 1. Oxford University Press, pp. 230–235, 2011.
ista: Vicoso B, Bachtrog D. 2011. Lack of global dosage compensation in Schistosoma
mansoni, a female-heterogametic parasite. Genome Biology and Evolution. 3(1),
230–235.
mla: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation in
Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and Evolution,
vol. 3, no. 1, Oxford University Press, 2011, pp. 230–35, doi:10.1093/gbe/evr010.
short: B. Vicoso, D. Bachtrog, Genome Biology and Evolution 3 (2011) 230–235.
date_created: 2018-12-11T11:55:33Z
date_published: 2011-02-11T00:00:00Z
date_updated: 2021-01-12T06:55:08Z
day: '11'
ddc:
- '570'
doi: 10.1093/gbe/evr010
extern: '1'
file:
- access_level: open_access
checksum: 7855c134436e4f6a13d63b6606d7e8dd
content_type: application/pdf
creator: dernst
date_created: 2019-05-10T07:41:28Z
date_updated: 2020-07-14T12:45:27Z
file_id: '6395'
file_name: 2011_GBE_Vicoso.pdf
file_size: 212547
relation: main_file
file_date_updated: 2020-07-14T12:45:27Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 230 - 235
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '4966'
quality_controlled: '1'
status: public
title: Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic
parasite
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2011'
...