---
_id: '12192'
abstract:
- lang: eng
text: Transposable elements (TEs), the movement of which can damage the genome,
are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in
the sperm companion cell – vegetative cell (VC) – of the flowering plant Arabidopsis
thaliana. However, the extent and mechanism of this activation are unknown. Here
we show that about 100 heterochromatic TEs are activated in VCs, mostly by DEMETER-catalyzed
DNA demethylation. We further demonstrate that DEMETER access to some of these
TEs is permitted by the natural depletion of linker histone H1 in VCs. Ectopically
expressed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent
mechanism. We demonstrate that H1 is required for heterochromatin condensation
in plant cells and show that H1 overexpression creates heterochromatic foci in
the VC progenitor cell. Taken together, our results demonstrate that the natural
depletion of H1 during male gametogenesis facilitates DEMETER-directed DNA demethylation,
heterochromatin relaxation, and TE activation.
acknowledgement: We thank David Twell for the pDONR-P4-P1R-pLAT52 and pDONR-P2R-P3-mRFP
vectors, the John Innes Centre Bioimaging Facility (Elaine Barclay and Grant Calder)
for their assistance with microscopy, and the Norwich BioScience Institute Partnership
Computing infrastructure for Science Group for High Performance Computing resources.
This work was funded by a Biotechnology and Biological Sciences Research Council
(BBSRC) David Phillips Fellowship (BB/L025043/1; SH, JZ and XF), a European Research
Council Starting Grant ('SexMeth' 804981; XF) and a Grant to Exceptional Researchers
by the Gatsby Charitable Foundation (SH and XF).
article_number: '42530'
article_processing_charge: No
article_type: original
author:
- first_name: Shengbo
full_name: He, Shengbo
last_name: He
- first_name: Martin
full_name: Vickers, Martin
last_name: Vickers
- first_name: Jingyi
full_name: Zhang, Jingyi
last_name: Zhang
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
citation:
ama: He S, Vickers M, Zhang J, Feng X. Natural depletion of histone H1 in sex cells
causes DNA demethylation, heterochromatin decondensation and transposon activation.
eLife. 2019;8. doi:10.7554/elife.42530
apa: He, S., Vickers, M., Zhang, J., & Feng, X. (2019). Natural depletion of
histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation
and transposon activation. ELife. eLife Sciences Publications, Ltd. https://doi.org/10.7554/elife.42530
chicago: He, Shengbo, Martin Vickers, Jingyi Zhang, and Xiaoqi Feng. “Natural Depletion
of Histone H1 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation
and Transposon Activation.” ELife. eLife Sciences Publications, Ltd, 2019.
https://doi.org/10.7554/elife.42530.
ieee: S. He, M. Vickers, J. Zhang, and X. Feng, “Natural depletion of histone H1
in sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation,” eLife, vol. 8. eLife Sciences Publications, Ltd, 2019.
ista: He S, Vickers M, Zhang J, Feng X. 2019. Natural depletion of histone H1 in
sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation. eLife. 8, 42530.
mla: He, Shengbo, et al. “Natural Depletion of Histone H1 in Sex Cells Causes DNA
Demethylation, Heterochromatin Decondensation and Transposon Activation.” ELife,
vol. 8, 42530, eLife Sciences Publications, Ltd, 2019, doi:10.7554/elife.42530.
short: S. He, M. Vickers, J. Zhang, X. Feng, ELife 8 (2019).
date_created: 2023-01-16T09:17:21Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2023-05-08T10:54:12Z
day: '28'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.7554/elife.42530
extern: '1'
external_id:
unknown:
- '31135340'
file:
- access_level: open_access
checksum: ea6b89c20d59e5eb3646916fe5d568ad
content_type: application/pdf
creator: alisjak
date_created: 2023-02-07T09:42:46Z
date_updated: 2023-02-07T09:42:46Z
file_id: '12525'
file_name: 2019_elife_He.pdf
file_size: 2493837
relation: main_file
success: 1
file_date_updated: 2023-02-07T09:42:46Z
has_accepted_license: '1'
intvolume: ' 8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594752/
month: '05'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications, Ltd
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin
decondensation and transposon activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2019'
...
---
_id: '12190'
abstract:
- lang: eng
text: Meiotic crossover frequency varies within genomes, which influences genetic
diversity and adaptation. In turn, genetic variation within populations can act
to modify crossover frequency in cis and trans. To identify genetic variation
that controls meiotic crossover frequency, we screened Arabidopsis accessions
using fluorescent recombination reporters. We mapped a genetic modifier of crossover
frequency in Col × Bur populations of Arabidopsis to a premature stop codon within
TBP-ASSOCIATED FACTOR 4b (TAF4b), which encodes a subunit of the RNA polymerase
II general transcription factor TFIID. The Arabidopsis taf4b mutation is a rare
variant found in the British Isles, originating in South-West Ireland. Using genetics,
genomics, and immunocytology, we demonstrate a genome-wide decrease in taf4b crossovers,
with strongest reduction in the sub-telomeric regions. Using RNA sequencing (RNA-seq)
from purified meiocytes, we show that TAF4b expression is meiocyte enriched, whereas
its paralog TAF4 is broadly expressed. Consistent with the role of TFIID in promoting
gene expression, RNA-seq of wild-type and taf4b meiocytes identified widespread
transcriptional changes, including in genes that regulate the meiotic cell cycle
and recombination. Therefore, TAF4b duplication is associated with acquisition
of meiocyte-specific expression and promotion of germline transcription, which
act directly or indirectly to elevate crossovers. This identifies a novel mode
of meiotic recombination control via a general transcription factor.
acknowledgement: "We thank Gregory Copenhaver (University of North Carolina), Avraham
Levy (The Weizmann Institute), and Scott Poethig (University of Pennsylvania) for
FTLs; Piotr Ziolkowski for Col-420/Bur seed; Sureshkumar Balasubramanian\r\n(Monash
University) for providing British and Irish Arabidopsis accessions; Mathilde Grelon
(INRA, Versailles) for providing the MLH1 antibody; and the Gurdon Institute for
access to microscopes. This work was supported by a BBSRC DTP studentship (E.J.L.),
European Research Area Network for Coordinating Action in Plant Sciences/BBSRC ‘‘DeCOP’’
(BB/M004937/1; C.L.), a BBSRC David Phillips Fellowship (BB/L025043/1; H.G. and
X.F.), the European Research Council (CoG ‘‘SynthHotspot,’’ A.J.T., C.L., and I.R.H.;
StG ‘‘SexMeth,’’ X.F.), and a Sainsbury Charitable Foundation Studentship (A.R.B.)."
article_processing_charge: No
article_type: original
author:
- first_name: Emma J.
full_name: Lawrence, Emma J.
last_name: Lawrence
- first_name: Hongbo
full_name: Gao, Hongbo
last_name: Gao
- first_name: Andrew J.
full_name: Tock, Andrew J.
last_name: Tock
- first_name: Christophe
full_name: Lambing, Christophe
last_name: Lambing
- first_name: Alexander R.
full_name: Blackwell, Alexander R.
last_name: Blackwell
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Ian R.
full_name: Henderson, Ian R.
last_name: Henderson
citation:
ama: Lawrence EJ, Gao H, Tock AJ, et al. Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis. Current
Biology. 2019;29(16):2676-2686.e3. doi:10.1016/j.cub.2019.06.084
apa: Lawrence, E. J., Gao, H., Tock, A. J., Lambing, C., Blackwell, A. R., Feng,
X., & Henderson, I. R. (2019). Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis. Current
Biology. Elsevier BV. https://doi.org/10.1016/j.cub.2019.06.084
chicago: Lawrence, Emma J., Hongbo Gao, Andrew J. Tock, Christophe Lambing, Alexander
R. Blackwell, Xiaoqi Feng, and Ian R. Henderson. “Natural Variation in TBP-ASSOCIATED
FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.”
Current Biology. Elsevier BV, 2019. https://doi.org/10.1016/j.cub.2019.06.084.
ieee: E. J. Lawrence et al., “Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis,” Current
Biology, vol. 29, no. 16. Elsevier BV, p. 2676–2686.e3, 2019.
ista: Lawrence EJ, Gao H, Tock AJ, Lambing C, Blackwell AR, Feng X, Henderson IR.
2019. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover
and germline transcription in Arabidopsis. Current Biology. 29(16), 2676–2686.e3.
mla: Lawrence, Emma J., et al. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls
Meiotic Crossover and Germline Transcription in Arabidopsis.” Current Biology,
vol. 29, no. 16, Elsevier BV, 2019, p. 2676–2686.e3, doi:10.1016/j.cub.2019.06.084.
short: E.J. Lawrence, H. Gao, A.J. Tock, C. Lambing, A.R. Blackwell, X. Feng, I.R.
Henderson, Current Biology 29 (2019) 2676–2686.e3.
date_created: 2023-01-16T09:16:33Z
date_published: 2019-08-19T00:00:00Z
date_updated: 2023-05-08T10:54:54Z
day: '19'
department:
- _id: XiFe
doi: 10.1016/j.cub.2019.06.084
extern: '1'
external_id:
pmid:
- '31378616'
intvolume: ' 29'
issue: '16'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '08'
oa_version: None
page: 2676-2686.e3
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and
germline transcription in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2019'
...
---
_id: '8305'
abstract:
- lang: eng
text: In this paper, we present the first fully asynchronous distributed key generation
(ADKG) algorithm as well as the first distributed key generation algorithm that
can create keys with a dual (f,2f+1)−threshold that are necessary for scalable
consensus (which so far needs a trusted dealer assumption). In order to create
a DKG with a dual (f,2f+1)− threshold we first answer in the affirmative the open
question posed by Cachin et al. how to create an AVSS protocol with recovery thresholds
f+1Cryptology
ePrint Archive.'
apa: 'Kokoris Kogias, E., Spiegelman, A., Malkhi, D., & Abraham, I. (n.d.).
Bootstrapping consensus without trusted setup: fully asynchronous distributed
key generation. Cryptology ePrint Archive.'
chicago: 'Kokoris Kogias, Eleftherios, Alexander Spiegelman, Dahlia Malkhi, and
Ittai Abraham. “Bootstrapping Consensus without Trusted Setup: Fully Asynchronous
Distributed Key Generation.” Cryptology EPrint Archive, n.d.'
ieee: 'E. Kokoris Kogias, A. Spiegelman, D. Malkhi, and I. Abraham, “Bootstrapping
consensus without trusted setup: fully asynchronous distributed key generation,”
Cryptology ePrint Archive. .'
ista: 'Kokoris Kogias E, Spiegelman A, Malkhi D, Abraham I. Bootstrapping consensus
without trusted setup: fully asynchronous distributed key generation. Cryptology
ePrint Archive, 2019/1015.'
mla: 'Kokoris Kogias, Eleftherios, et al. “Bootstrapping Consensus without Trusted
Setup: Fully Asynchronous Distributed Key Generation.” Cryptology EPrint Archive,
2019/1015.'
short: E. Kokoris Kogias, A. Spiegelman, D. Malkhi, I. Abraham, Cryptology EPrint
Archive (n.d.).
date_created: 2020-08-26T12:18:00Z
date_published: 2019-09-10T00:00:00Z
date_updated: 2023-05-10T09:27:54Z
day: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/1015
month: '09'
oa: 1
oa_version: Preprint
publication: Cryptology ePrint Archive
publication_status: submitted
status: public
title: 'Bootstrapping consensus without trusted setup: fully asynchronous distributed
key generation'
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '12901'
article_processing_charge: No
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Janos
full_name: Kiss, Janos
id: 3D3A06F8-F248-11E8-B48F-1D18A9856A87
last_name: Kiss
- first_name: Stefano
full_name: Elefante, Stefano
id: 490F40CE-F248-11E8-B48F-1D18A9856A87
last_name: Elefante
citation:
ama: 'Schlögl A, Kiss J, Elefante S. Is Debian suitable for running an HPC Cluster?
In: AHPC19 - Austrian HPC Meeting 2019 . Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz; 2019:25.'
apa: 'Schlögl, A., Kiss, J., & Elefante, S. (2019). Is Debian suitable for running
an HPC Cluster? In AHPC19 - Austrian HPC Meeting 2019 (p. 25). Grundlsee,
Austria: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz.'
chicago: Schlögl, Alois, Janos Kiss, and Stefano Elefante. “Is Debian Suitable for
Running an HPC Cluster?” In AHPC19 - Austrian HPC Meeting 2019 , 25. Institut
für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019.
ieee: A. Schlögl, J. Kiss, and S. Elefante, “Is Debian suitable for running an HPC
Cluster?,” in AHPC19 - Austrian HPC Meeting 2019 , Grundlsee, Austria,
2019, p. 25.
ista: 'Schlögl A, Kiss J, Elefante S. 2019. Is Debian suitable for running an HPC
Cluster? AHPC19 - Austrian HPC Meeting 2019 . AHPC: Austrian HPC Meeting, 25.'
mla: Schlögl, Alois, et al. “Is Debian Suitable for Running an HPC Cluster?” AHPC19
- Austrian HPC Meeting 2019 , Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz, 2019, p. 25.
short: A. Schlögl, J. Kiss, S. Elefante, in:, AHPC19 - Austrian HPC Meeting 2019
, Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz,
2019, p. 25.
conference:
end_date: 2019-02-27
location: Grundlsee, Austria
name: 'AHPC: Austrian HPC Meeting'
start_date: 2019-02-25
date_created: 2023-05-05T12:48:48Z
date_published: 2019-02-27T00:00:00Z
date_updated: 2023-05-16T07:29:32Z
day: '27'
ddc:
- '000'
department:
- _id: ScienComp
file:
- access_level: open_access
checksum: acc8272027faaf30709c51ac5c58ffa4
content_type: application/pdf
creator: dernst
date_created: 2023-05-16T07:27:09Z
date_updated: 2023-05-16T07:27:09Z
file_id: '12970'
file_name: 2019_AHPC_Schloegl.pdf
file_size: 1097603
relation: main_file
success: 1
file_date_updated: 2023-05-16T07:27:09Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc19/BOOKLET_AHPC19.pdf
month: '02'
oa: 1
oa_version: Published Version
page: '25'
publication: 'AHPC19 - Austrian HPC Meeting 2019 '
publication_status: published
publisher: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz
status: public
title: Is Debian suitable for running an HPC Cluster?
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11060'
abstract:
- lang: eng
text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
(ER) that is gated by the nuclear pore complex. It is unknown whether proteins
of the INM and ER are degraded through shared or distinct pathways in mammalian
cells. We applied dynamic proteomics to profile protein half-lives and report
that INM and ER residents turn over at similar rates, indicating that the INM’s
unique topology is not a barrier to turnover. Using a microscopy approach, we
observed that the proteasome can degrade INM proteins in situ. However, we also
uncovered evidence for selective, vesicular transport-mediated turnover of a single
INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
trafficking to lysosomes. This work demonstrates that the INM can be dynamically
remodeled in response to environmental inputs.
article_number: e49796
article_processing_charge: No
article_type: original
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Hsiao
full_name: Tsai, Hsiao
last_name: Tsai
- first_name: Juliana
full_name: Capitanio, Juliana
last_name: Capitanio
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance
of the inner nuclear membrane protein emerin by vesicular transport during ER
stress. eLife. 2019;8. doi:10.7554/elife.49796
apa: Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., & Hetzer, M. (2019).
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.49796
chicago: Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
Martin Hetzer. “Selective Clearance of the Inner Nuclear Membrane Protein Emerin
by Vesicular Transport during ER Stress.” ELife. eLife Sciences Publications,
2019. https://doi.org/10.7554/elife.49796.
ieee: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Selective
clearance of the inner nuclear membrane protein emerin by vesicular transport
during ER stress,” eLife, vol. 8. eLife Sciences Publications, 2019.
ista: Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Selective clearance
of the inner nuclear membrane protein emerin by vesicular transport during ER
stress. eLife. 8, e49796.
mla: Buchwalter, Abigail, et al. “Selective Clearance of the Inner Nuclear Membrane
Protein Emerin by Vesicular Transport during ER Stress.” ELife, vol. 8,
e49796, eLife Sciences Publications, 2019, doi:10.7554/elife.49796.
short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, ELife 8 (2019).
date_created: 2022-04-07T07:45:02Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2023-05-31T06:36:22Z
day: '10'
ddc:
- '570'
doi: 10.7554/elife.49796
extern: '1'
external_id:
pmid:
- '31599721'
file:
- access_level: open_access
checksum: 1e8672a1e9c3dc0a2d3d0dad89673616
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T08:18:01Z
date_updated: 2022-04-08T08:18:01Z
file_id: '11138'
file_name: 2019_eLife_Buchwalter.pdf
file_size: 6984654
relation: main_file
success: 1
file_date_updated: 2022-04-08T08:18:01Z
has_accepted_license: '1'
intvolume: ' 8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '13079'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 8
year: '2019'
...
---
_id: '13079'
abstract:
- lang: eng
text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
(ER) that is gated by the nuclear pore complex. It is unknown whether proteins
of the INM and ER are degraded through shared or distinct pathways in mammalian
cells. We applied dynamic proteomics to profile protein half-lives and report
that INM and ER residents turn over at similar rates, indicating that the INM’s
unique topology is not a barrier to turnover. Using a microscopy approach, we
observed that the proteasome can degrade INM proteins in situ. However, we also
uncovered evidence for selective, vesicular transport-mediated turnover of a single
INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
trafficking to lysosomes. This work demonstrates that the INM can be dynamically
remodeled in response to environmental inputs.
article_processing_charge: No
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Hsiao
full_name: Tsai, Hsiao
last_name: Tsai
- first_name: Juliana
full_name: Capitanio, Juliana
last_name: Capitanio
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective
clearance of the inner nuclear membrane protein emerin by vesicular transport
during ER stress. 2019. doi:10.5061/DRYAD.N0R525H'
apa: 'Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., & Hetzer, M. (2019).
Data from: Selective clearance of the inner nuclear membrane protein emerin by
vesicular transport during ER stress. Dryad. https://doi.org/10.5061/DRYAD.N0R525H'
chicago: 'Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
Martin Hetzer. “Data from: Selective Clearance of the Inner Nuclear Membrane Protein
Emerin by Vesicular Transport during ER Stress.” Dryad, 2019. https://doi.org/10.5061/DRYAD.N0R525H.'
ieee: 'A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress.” Dryad, 2019.'
ista: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress, Dryad, 10.5061/DRYAD.N0R525H.'
mla: 'Buchwalter, Abigail, et al. Data from: Selective Clearance of the Inner
Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress. Dryad,
2019, doi:10.5061/DRYAD.N0R525H.'
short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, (2019).
date_created: 2023-05-23T17:09:30Z
date_published: 2019-10-28T00:00:00Z
date_updated: 2023-05-31T06:36:23Z
day: '28'
ddc:
- '570'
doi: 10.5061/DRYAD.N0R525H
extern: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.n0r525h
month: '10'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '11060'
relation: used_in_publication
status: public
status: public
title: 'Data from: Selective clearance of the inner nuclear membrane protein emerin
by vesicular transport during ER stress'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '6989'
abstract:
- lang: eng
text: 'When can a polyomino piece of paper be folded into a unit cube? Prior work
studied tree-like polyominoes, but polyominoes with holes remain an intriguing
open problem. We present sufficient conditions for a polyomino with hole(s) to
fold into a cube, and conditions under which cube folding is impossible. In particular,
we show that all but five special simple holes guarantee foldability. '
acknowledgement: This research was performed in part at the 33rd BellairsWinter Workshop on Computational Geometry. Wethank
all other participants for a fruitful atmosphere.
article_processing_charge: No
author:
- first_name: Oswin
full_name: Aichholzer, Oswin
last_name: Aichholzer
- first_name: Hugo A
full_name: Akitaya, Hugo A
last_name: Akitaya
- first_name: Kenneth C
full_name: Cheung, Kenneth C
last_name: Cheung
- first_name: Erik D
full_name: Demaine, Erik D
last_name: Demaine
- first_name: Martin L
full_name: Demaine, Martin L
last_name: Demaine
- first_name: Sandor P
full_name: Fekete, Sandor P
last_name: Fekete
- first_name: Linda
full_name: Kleist, Linda
last_name: Kleist
- first_name: Irina
full_name: Kostitsyna, Irina
last_name: Kostitsyna
- first_name: Maarten
full_name: Löffler, Maarten
last_name: Löffler
- first_name: Zuzana
full_name: Masárová, Zuzana
id: 45CFE238-F248-11E8-B48F-1D18A9856A87
last_name: Masárová
orcid: 0000-0002-6660-1322
- first_name: Klara
full_name: Mundilova, Klara
last_name: Mundilova
- first_name: Christiane
full_name: Schmidt, Christiane
last_name: Schmidt
citation:
ama: 'Aichholzer O, Akitaya HA, Cheung KC, et al. Folding polyominoes with holes
into a cube. In: Proceedings of the 31st Canadian Conference on Computational
Geometry. Canadian Conference on Computational Geometry; 2019:164-170.'
apa: 'Aichholzer, O., Akitaya, H. A., Cheung, K. C., Demaine, E. D., Demaine, M.
L., Fekete, S. P., … Schmidt, C. (2019). Folding polyominoes with holes into a
cube. In Proceedings of the 31st Canadian Conference on Computational Geometry
(pp. 164–170). Edmonton, Canada: Canadian Conference on Computational Geometry.'
chicago: Aichholzer, Oswin, Hugo A Akitaya, Kenneth C Cheung, Erik D Demaine, Martin
L Demaine, Sandor P Fekete, Linda Kleist, et al. “Folding Polyominoes with Holes
into a Cube.” In Proceedings of the 31st Canadian Conference on Computational
Geometry, 164–70. Canadian Conference on Computational Geometry, 2019.
ieee: O. Aichholzer et al., “Folding polyominoes with holes into a cube,”
in Proceedings of the 31st Canadian Conference on Computational Geometry,
Edmonton, Canada, 2019, pp. 164–170.
ista: 'Aichholzer O, Akitaya HA, Cheung KC, Demaine ED, Demaine ML, Fekete SP, Kleist
L, Kostitsyna I, Löffler M, Masárová Z, Mundilova K, Schmidt C. 2019. Folding
polyominoes with holes into a cube. Proceedings of the 31st Canadian Conference
on Computational Geometry. CCCG: Canadian Conference in Computational Geometry,
164–170.'
mla: Aichholzer, Oswin, et al. “Folding Polyominoes with Holes into a Cube.” Proceedings
of the 31st Canadian Conference on Computational Geometry, Canadian Conference
on Computational Geometry, 2019, pp. 164–70.
short: O. Aichholzer, H.A. Akitaya, K.C. Cheung, E.D. Demaine, M.L. Demaine, S.P.
Fekete, L. Kleist, I. Kostitsyna, M. Löffler, Z. Masárová, K. Mundilova, C. Schmidt,
in:, Proceedings of the 31st Canadian Conference on Computational Geometry, Canadian
Conference on Computational Geometry, 2019, pp. 164–170.
conference:
end_date: 2019-08-10
location: Edmonton, Canada
name: 'CCCG: Canadian Conference in Computational Geometry'
start_date: 2019-08-08
date_created: 2019-11-04T16:46:11Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-08-04T10:57:42Z
day: '01'
department:
- _id: HeEd
external_id:
arxiv:
- '1910.09917'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://cccg.ca/proceedings/2019/proceedings.pdf
month: '08'
oa: 1
oa_version: Published Version
page: 164-170
publication: Proceedings of the 31st Canadian Conference on Computational Geometry
publication_status: published
publisher: Canadian Conference on Computational Geometry
quality_controlled: '1'
related_material:
record:
- id: '8317'
relation: extended_version
status: public
scopus_import: '1'
status: public
title: Folding polyominoes with holes into a cube
type: conference
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
year: '2019'
...
---
_id: '13366'
abstract:
- lang: eng
text: The ability to reversibly assemble nanoparticles using light is both fundamentally
interesting and important for applications ranging from reversible data storage
to controlled drug delivery. Here, the diverse approaches that have so far been
developed to control the self-assembly of nanoparticles using light are reviewed
and compared. These approaches include functionalizing nanoparticles with monolayers
of photoresponsive molecules, placing them in photoresponsive media capable of
reversibly protonating the particles under light, and decorating plasmonic nanoparticles
with thermoresponsive polymers, to name just a few. The applicability of these
methods to larger, micrometer-sized particles is also discussed. Finally, several
perspectives on further developments in the field are offered.
article_number: '1905866'
article_processing_charge: No
article_type: original
author:
- first_name: Tong
full_name: Bian, Tong
last_name: Bian
- first_name: Zonglin
full_name: Chu, Zonglin
last_name: Chu
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Bian T, Chu Z, Klajn R. The many ways to assemble nanoparticles using light.
Advanced Materials. 2019;32(20). doi:10.1002/adma.201905866
apa: Bian, T., Chu, Z., & Klajn, R. (2019). The many ways to assemble nanoparticles
using light. Advanced Materials. Wiley. https://doi.org/10.1002/adma.201905866
chicago: Bian, Tong, Zonglin Chu, and Rafal Klajn. “The Many Ways to Assemble Nanoparticles
Using Light.” Advanced Materials. Wiley, 2019. https://doi.org/10.1002/adma.201905866.
ieee: T. Bian, Z. Chu, and R. Klajn, “The many ways to assemble nanoparticles using
light,” Advanced Materials, vol. 32, no. 20. Wiley, 2019.
ista: Bian T, Chu Z, Klajn R. 2019. The many ways to assemble nanoparticles using
light. Advanced Materials. 32(20), 1905866.
mla: Bian, Tong, et al. “The Many Ways to Assemble Nanoparticles Using Light.” Advanced
Materials, vol. 32, no. 20, 1905866, Wiley, 2019, doi:10.1002/adma.201905866.
short: T. Bian, Z. Chu, R. Klajn, Advanced Materials 32 (2019).
date_created: 2023-08-01T09:37:26Z
date_published: 2019-11-19T00:00:00Z
date_updated: 2023-08-07T10:23:41Z
day: '19'
doi: 10.1002/adma.201905866
extern: '1'
external_id:
pmid:
- '31709655'
intvolume: ' 32'
issue: '20'
keyword:
- Mechanical Engineering
- Mechanics of Materials
- General Materials Science
language:
- iso: eng
month: '11'
oa_version: None
pmid: 1
publication: Advanced Materials
publication_identifier:
eissn:
- 1521-4095
issn:
- 0935-9648
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: The many ways to assemble nanoparticles using light
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2019'
...
---
_id: '13373'
abstract:
- lang: eng
text: The reversible photoisomerization of azobenzene has been utilized to construct
a plethora of systems in which optical, electronic, catalytic, and other properties
can be controlled by light. However, owing to azobenzene’s hydrophobic nature,
most of these examples have been realized only in organic solvents, and systems
operating in water are relatively scarce. Here, we show that by coadsorbing the
inherently hydrophobic azobenzenes with water-solubilizing ligands on the same
nanoparticulate platforms, it is possible to render them essentially water-soluble.
To this end, we developed a modified nanoparticle functionalization procedure
allowing us to precisely fine-tune the amount of azobenzene on the functionalized
nanoparticles. Molecular dynamics simulations helped us to identify two distinct
supramolecular architectures (depending on the length of the background ligand)
on these nanoparticles, which can explain their excellent aqueous solubilities.
Azobenzenes adsorbed on these water-soluble nanoparticles exhibit highly reversible
photoisomerization upon exposure to UV and visible light. Importantly, the mixed-monolayer
approach allowed us to systematically investigate how the background ligand affects
the switching properties of azobenzene. We found that the nature of the background
ligand has a profound effect on the kinetics of azobenzene switching. For example,
a hydroxy-terminated background ligand is capable of accelerating the back-isomerization
reaction by more than 6000-fold. These results pave the way toward the development
of novel light-responsive nanomaterials operating in aqueous media and, in the
long run, in biological environments.
article_processing_charge: No
article_type: original
author:
- first_name: Zonglin
full_name: Chu, Zonglin
last_name: Chu
- first_name: Yanxiao
full_name: Han, Yanxiao
last_name: Han
- first_name: Tong
full_name: Bian, Tong
last_name: Bian
- first_name: Soumen
full_name: De, Soumen
last_name: De
- first_name: Petr
full_name: Král, Petr
last_name: Král
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Chu Z, Han Y, Bian T, De S, Král P, Klajn R. Supramolecular control of azobenzene
switching on nanoparticles. Journal of the American Chemical Society. 2019;141(5):1949-1960.
doi:10.1021/jacs.8b09638
apa: Chu, Z., Han, Y., Bian, T., De, S., Král, P., & Klajn, R. (2019). Supramolecular
control of azobenzene switching on nanoparticles. Journal of the American Chemical
Society. American Chemical Society. https://doi.org/10.1021/jacs.8b09638
chicago: Chu, Zonglin, Yanxiao Han, Tong Bian, Soumen De, Petr Král, and Rafal Klajn.
“Supramolecular Control of Azobenzene Switching on Nanoparticles.” Journal
of the American Chemical Society. American Chemical Society, 2019. https://doi.org/10.1021/jacs.8b09638.
ieee: Z. Chu, Y. Han, T. Bian, S. De, P. Král, and R. Klajn, “Supramolecular control
of azobenzene switching on nanoparticles,” Journal of the American Chemical
Society, vol. 141, no. 5. American Chemical Society, pp. 1949–1960, 2019.
ista: Chu Z, Han Y, Bian T, De S, Král P, Klajn R. 2019. Supramolecular control
of azobenzene switching on nanoparticles. Journal of the American Chemical Society.
141(5), 1949–1960.
mla: Chu, Zonglin, et al. “Supramolecular Control of Azobenzene Switching on Nanoparticles.”
Journal of the American Chemical Society, vol. 141, no. 5, American Chemical
Society, 2019, pp. 1949–60, doi:10.1021/jacs.8b09638.
short: Z. Chu, Y. Han, T. Bian, S. De, P. Král, R. Klajn, Journal of the American
Chemical Society 141 (2019) 1949–1960.
date_created: 2023-08-01T09:39:19Z
date_published: 2019-02-06T00:00:00Z
date_updated: 2023-08-07T10:51:12Z
day: '06'
doi: 10.1021/jacs.8b09638
extern: '1'
external_id:
pmid:
- '30595017'
intvolume: ' 141'
issue: '5'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '02'
oa_version: Published Version
page: 1949-1960
pmid: 1
publication: Journal of the American Chemical Society
publication_identifier:
eissn:
- 1520-5126
issn:
- 0002-7863
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Supramolecular control of azobenzene switching on nanoparticles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 141
year: '2019'
...
---
_id: '13372'
abstract:
- lang: eng
text: 'The capacity to respond or adapt to environmental changes is an intrinsic
property of living systems that comprise highly-connected subcomponents communicating
through chemical networks. The development of responsive synthetic systems is
a relatively new research area that covers different disciplines, among which
nanochemistry brings conceptually new demonstrations. Especially attractive are
ligand-protected gold nanoparticles, which have been extensively used over the
last decade as building blocks in constructing superlattices or dynamic aggregates,
under the effect of an applied stimulus. To reflect the importance of surface
chemistry and nanoparticle core composition in the dynamic self-assembly of nanoparticles,
we provide here an overview of various available stimuli, as tools for synthetic
chemists to exploit. Along with this task, the review starts with the use of chemical
stimuli such as solvent, pH, gases, metal ions or biomolecules. It then focuses
on physical stimuli: temperature, magnetic and electric fields, as well as light.
To reflect on the increasing complexity of current architectures, we discuss systems
that are responsive to more than one stimulus, to finally encourage further research
by proposing future challenges.'
article_processing_charge: No
article_type: original
author:
- first_name: Marek
full_name: Grzelczak, Marek
last_name: Grzelczak
- first_name: Luis M.
full_name: Liz-Marzán, Luis M.
last_name: Liz-Marzán
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Grzelczak M, Liz-Marzán LM, Klajn R. Stimuli-responsive self-assembly of nanoparticles.
Chemical Society Reviews. 2019;48(5):1342-1361. doi:10.1039/c8cs00787j
apa: Grzelczak, M., Liz-Marzán, L. M., & Klajn, R. (2019). Stimuli-responsive
self-assembly of nanoparticles. Chemical Society Reviews. Royal Society
of Chemistry. https://doi.org/10.1039/c8cs00787j
chicago: Grzelczak, Marek, Luis M. Liz-Marzán, and Rafal Klajn. “Stimuli-Responsive
Self-Assembly of Nanoparticles.” Chemical Society Reviews. Royal Society
of Chemistry, 2019. https://doi.org/10.1039/c8cs00787j.
ieee: M. Grzelczak, L. M. Liz-Marzán, and R. Klajn, “Stimuli-responsive self-assembly
of nanoparticles,” Chemical Society Reviews, vol. 48, no. 5. Royal Society
of Chemistry, pp. 1342–1361, 2019.
ista: Grzelczak M, Liz-Marzán LM, Klajn R. 2019. Stimuli-responsive self-assembly
of nanoparticles. Chemical Society Reviews. 48(5), 1342–1361.
mla: Grzelczak, Marek, et al. “Stimuli-Responsive Self-Assembly of Nanoparticles.”
Chemical Society Reviews, vol. 48, no. 5, Royal Society of Chemistry, 2019,
pp. 1342–61, doi:10.1039/c8cs00787j.
short: M. Grzelczak, L.M. Liz-Marzán, R. Klajn, Chemical Society Reviews 48 (2019)
1342–1361.
date_created: 2023-08-01T09:38:52Z
date_published: 2019-01-28T00:00:00Z
date_updated: 2023-08-07T10:48:31Z
day: '28'
doi: 10.1039/c8cs00787j
extern: '1'
external_id:
pmid:
- '30688963'
intvolume: ' 48'
issue: '5'
keyword:
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1039/C8CS00787J
month: '01'
oa: 1
oa_version: Published Version
page: 1342-1361
pmid: 1
publication: Chemical Society Reviews
publication_identifier:
eissn:
- 1460-4744
issn:
- 0306-0012
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stimuli-responsive self-assembly of nanoparticles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2019'
...