---
_id: '7128'
abstract:
- lang: eng
text: Loss of functional cardiomyocytes is a major determinant of heart failure
after myocardial infarction. Previous high throughput screening studies have identified
a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate
cardiac regeneration in mice. Here, we show that all of the most effective of
these miRNAs activate nuclear localization of the master transcriptional cofactor
Yes-associated protein (YAP) and induce expression of YAP-responsive genes. In
particular, miR-199a-3p directly targets two mRNAs coding for proteins impinging
on the Hippo pathway, the upstream YAP inhibitory kinase TAOK1, and the E3 ubiquitin
ligase β-TrCP, which leads to YAP degradation. Several of the pro-proliferative
miRNAs (including miR-199a-3p) also inhibit filamentous actin depolymerization
by targeting Cofilin2, a process that by itself activates YAP nuclear translocation.
Thus, activation of YAP and modulation of the actin cytoskeleton are major components
of the pro-proliferative action of miR-199a-3p and other miRNAs that induce cardiomyocyte
proliferation.
article_processing_charge: Yes
article_type: original
author:
- first_name: Consuelo
full_name: Torrini, Consuelo
last_name: Torrini
- first_name: Ryan J
full_name: Cubero, Ryan J
id: 850B2E12-9CD4-11E9-837F-E719E6697425
last_name: Cubero
orcid: 0000-0003-0002-1867
- first_name: Ellen
full_name: Dirkx, Ellen
last_name: Dirkx
- first_name: Luca
full_name: Braga, Luca
last_name: Braga
- first_name: Hashim
full_name: Ali, Hashim
last_name: Ali
- first_name: Giulia
full_name: Prosdocimo, Giulia
last_name: Prosdocimo
- first_name: Maria Ines
full_name: Gutierrez, Maria Ines
last_name: Gutierrez
- first_name: Chiara
full_name: Collesi, Chiara
last_name: Collesi
- first_name: Danilo
full_name: Licastro, Danilo
last_name: Licastro
- first_name: Lorena
full_name: Zentilin, Lorena
last_name: Zentilin
- first_name: Miguel
full_name: Mano, Miguel
last_name: Mano
- first_name: Serena
full_name: Zacchigna, Serena
last_name: Zacchigna
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Matteo
full_name: Marsili, Matteo
last_name: Marsili
- first_name: Areejit
full_name: Samal, Areejit
last_name: Samal
- first_name: Mauro
full_name: Giacca, Mauro
last_name: Giacca
citation:
ama: Torrini C, Cubero RJ, Dirkx E, et al. Common regulatory pathways mediate activity
of microRNAs inducing cardiomyocyte proliferation. Cell Reports. 2019;27(9):2759-2771.e5.
doi:10.1016/j.celrep.2019.05.005
apa: Torrini, C., Cubero, R. J., Dirkx, E., Braga, L., Ali, H., Prosdocimo, G.,
… Giacca, M. (2019). Common regulatory pathways mediate activity of microRNAs
inducing cardiomyocyte proliferation. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2019.05.005
chicago: Torrini, Consuelo, Ryan J Cubero, Ellen Dirkx, Luca Braga, Hashim Ali,
Giulia Prosdocimo, Maria Ines Gutierrez, et al. “Common Regulatory Pathways Mediate
Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.” Cell Reports.
Elsevier, 2019. https://doi.org/10.1016/j.celrep.2019.05.005.
ieee: C. Torrini et al., “Common regulatory pathways mediate activity of
microRNAs inducing cardiomyocyte proliferation,” Cell Reports, vol. 27,
no. 9. Elsevier, p. 2759–2771.e5, 2019.
ista: Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI,
Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili
M, Samal A, Giacca M. 2019. Common regulatory pathways mediate activity of microRNAs
inducing cardiomyocyte proliferation. Cell Reports. 27(9), 2759–2771.e5.
mla: Torrini, Consuelo, et al. “Common Regulatory Pathways Mediate Activity of MicroRNAs
Inducing Cardiomyocyte Proliferation.” Cell Reports, vol. 27, no. 9, Elsevier,
2019, p. 2759–2771.e5, doi:10.1016/j.celrep.2019.05.005.
short: C. Torrini, R.J. Cubero, E. Dirkx, L. Braga, H. Ali, G. Prosdocimo, M.I.
Gutierrez, C. Collesi, D. Licastro, L. Zentilin, M. Mano, S. Zacchigna, M. Vendruscolo,
M. Marsili, A. Samal, M. Giacca, Cell Reports 27 (2019) 2759–2771.e5.
date_created: 2019-11-26T22:30:07Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2021-01-12T08:11:56Z
day: '28'
ddc:
- '576'
doi: 10.1016/j.celrep.2019.05.005
extern: '1'
external_id:
pmid:
- '31141697'
file:
- access_level: open_access
checksum: c5d855d07263bfec718673385d0ea2d7
content_type: application/pdf
creator: rcubero
date_created: 2019-11-26T22:30:43Z
date_updated: 2020-07-14T12:47:50Z
file_id: '7129'
file_name: torrini_cellreports_2019.pdf
file_size: 4650750
relation: main_file
file_date_updated: 2020-07-14T12:47:50Z
has_accepted_license: '1'
intvolume: ' 27'
issue: '9'
keyword:
- cardiomyocyte
- cell cycle
- Cofilin2
- cytoskeleton
- Hippo
- microRNA
- regeneration
- YAP
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 2759-2771.e5
pmid: 1
publication: Cell Reports
publication_identifier:
issn:
- 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte
proliferation
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2019'
...
---
_id: '7130'
abstract:
- lang: eng
text: "We show that statistical criticality, i.e. the occurrence of power law frequency
distributions, arises in samples that are maximally informative about the underlying
generating process. In order to reach this conclusion, we first identify the frequency
with which different outcomes occur in a sample, as the variable carrying useful
information on the generative process. The entropy of the frequency, that we call
relevance, provides an upper bound to the number of informative bits. This differs
from the entropy of the data, that we take as a measure of resolution. Samples
that maximise relevance at a given resolution—that we call maximally informative
samples—exhibit statistical criticality. In particular, Zipf's law arises at the
optimal trade-off between resolution (i.e. compression) and relevance. As a byproduct,
we derive a bound of the maximal number of parameters that can be estimated from
a dataset, in the absence of prior knowledge on the generative model.\r\n\r\nFurthermore,
we relate criticality to the statistical properties of the representation of the
data generating process. We show that, as a consequence of the concentration property
of the asymptotic equipartition property, representations that are maximally informative
about the data generating process are characterised by an exponential distribution
of energy levels. This arises from a principle of minimal entropy, that is conjugate
of the maximum entropy principle in statistical mechanics. This explains why statistical
criticality requires no parameter fine tuning in maximally informative samples."
acknowledgement: We acknowledge interesting discussions with M Abbott, E Aurell, J
Barbier, R Monasson, T Mora, I Nemenman, N Tishby and R Zecchina. This research
was supported by the Kavli Foundation and the Centre of Excellence scheme of the
Research Council of Norway (Centre for Neural Computation) (RJC and YR), by the
Basic Science Research Program through the National Research Foundation of Korea
(NRF), funded by the Ministry of Education (2016R1D1A1B03932264) (JJ), and, in part,
by the ICTP through the OEA-AC-98 (JS).
article_number: '063402'
article_processing_charge: No
article_type: original
author:
- first_name: Ryan J
full_name: Cubero, Ryan J
id: 850B2E12-9CD4-11E9-837F-E719E6697425
last_name: Cubero
orcid: 0000-0003-0002-1867
- first_name: Junghyo
full_name: Jo, Junghyo
last_name: Jo
- first_name: Matteo
full_name: Marsili, Matteo
last_name: Marsili
- first_name: Yasser
full_name: Roudi, Yasser
last_name: Roudi
- first_name: Juyong
full_name: Song, Juyong
last_name: Song
citation:
ama: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. Statistical criticality arises
in most informative representations. Journal of Statistical Mechanics: Theory
and Experiment. 2019;2019(6). doi:10.1088/1742-5468/ab16c8'
apa: 'Cubero, R. J., Jo, J., Marsili, M., Roudi, Y., & Song, J. (2019). Statistical
criticality arises in most informative representations. Journal of Statistical
Mechanics: Theory and Experiment. IOP Publishing. https://doi.org/10.1088/1742-5468/ab16c8'
chicago: 'Cubero, Ryan J, Junghyo Jo, Matteo Marsili, Yasser Roudi, and Juyong Song.
“Statistical Criticality Arises in Most Informative Representations.” Journal
of Statistical Mechanics: Theory and Experiment. IOP Publishing, 2019. https://doi.org/10.1088/1742-5468/ab16c8.'
ieee: 'R. J. Cubero, J. Jo, M. Marsili, Y. Roudi, and J. Song, “Statistical criticality
arises in most informative representations,” Journal of Statistical Mechanics:
Theory and Experiment, vol. 2019, no. 6. IOP Publishing, 2019.'
ista: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. 2019. Statistical criticality
arises in most informative representations. Journal of Statistical Mechanics:
Theory and Experiment. 2019(6), 063402.'
mla: 'Cubero, Ryan J., et al. “Statistical Criticality Arises in Most Informative
Representations.” Journal of Statistical Mechanics: Theory and Experiment,
vol. 2019, no. 6, 063402, IOP Publishing, 2019, doi:10.1088/1742-5468/ab16c8.'
short: 'R.J. Cubero, J. Jo, M. Marsili, Y. Roudi, J. Song, Journal of Statistical
Mechanics: Theory and Experiment 2019 (2019).'
date_created: 2019-11-26T22:36:09Z
date_published: 2019-06-17T00:00:00Z
date_updated: 2021-01-12T08:11:57Z
day: '17'
doi: 10.1088/1742-5468/ab16c8
extern: '1'
external_id:
arxiv:
- '1808.00249'
intvolume: ' 2019'
issue: '6'
keyword:
- optimization under uncertainty
- source coding
- large deviation
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1808.00249
month: '06'
oa: 1
oa_version: Preprint
publication: 'Journal of Statistical Mechanics: Theory and Experiment'
publication_identifier:
issn:
- 1742-5468
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
status: public
title: Statistical criticality arises in most informative representations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2019
year: '2019'
...
---
_id: '7150'
abstract:
- lang: eng
text: "In this work, we use algebraic methods for studying distance computation
and subgraph detection tasks in the congested clique model. Specifically, we adapt
parallel matrix multiplication implementations to the congested clique, obtaining
an O(n1−2/ω) round matrix multiplication algorithm, where ω<2.3728639 is the exponent
of matrix multiplication. In conjunction with known techniques from centralised
algorithmics, this gives significant improvements over previous best upper bounds
in the congested clique model. The highlight results include:\r\n\r\n1. triangle
and 4-cycle counting in O(n0.158) rounds, improving upon the O(n1/3) algorithm
of Dolev et al. [DISC 2012],\r\n2. a (1+o(1))-approximation of all-pairs shortest
paths in O(n0.158) rounds, improving upon the O~(n1/2)-round (2+o(1))-approximation
algorithm given by Nanongkai [STOC 2014], and\r\n 3. computing the girth in O(n0.158)
rounds, which is the first non-trivial solution in this model.\r\n \r\nIn addition,
we present a novel constant-round combinatorial algorithm for detecting 4-cycles."
article_processing_charge: No
article_type: original
author:
- first_name: Keren
full_name: Censor-Hillel, Keren
last_name: Censor-Hillel
- first_name: Petteri
full_name: Kaski, Petteri
last_name: Kaski
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Christoph
full_name: Lenzen, Christoph
last_name: Lenzen
- first_name: Ami
full_name: Paz, Ami
last_name: Paz
- first_name: Jukka
full_name: Suomela, Jukka
last_name: Suomela
citation:
ama: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. Algebraic
methods in the congested clique. Distributed Computing. 2019;32(6):461-478.
doi:10.1007/s00446-016-0270-2
apa: Censor-Hillel, K., Kaski, P., Korhonen, J., Lenzen, C., Paz, A., & Suomela,
J. (2019). Algebraic methods in the congested clique. Distributed Computing.
Springer Nature. https://doi.org/10.1007/s00446-016-0270-2
chicago: Censor-Hillel, Keren, Petteri Kaski, Janne Korhonen, Christoph Lenzen,
Ami Paz, and Jukka Suomela. “Algebraic Methods in the Congested Clique.” Distributed
Computing. Springer Nature, 2019. https://doi.org/10.1007/s00446-016-0270-2.
ieee: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, and J. Suomela,
“Algebraic methods in the congested clique,” Distributed Computing, vol.
32, no. 6. Springer Nature, pp. 461–478, 2019.
ista: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. 2019. Algebraic
methods in the congested clique. Distributed Computing. 32(6), 461–478.
mla: Censor-Hillel, Keren, et al. “Algebraic Methods in the Congested Clique.” Distributed
Computing, vol. 32, no. 6, Springer Nature, 2019, pp. 461–78, doi:10.1007/s00446-016-0270-2.
short: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, J. Suomela, Distributed
Computing 32 (2019) 461–478.
date_created: 2019-12-05T09:49:49Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2021-01-12T08:12:05Z
day: '01'
doi: 10.1007/s00446-016-0270-2
extern: '1'
external_id:
arxiv:
- '1503.04963'
intvolume: ' 32'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1503.04963
month: '12'
oa: 1
oa_version: Preprint
page: 461-478
publication: Distributed Computing
publication_identifier:
issn:
- 0178-2770
- 1432-0452
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Algebraic methods in the congested clique
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2019'
...
---
_id: '7171'
abstract:
- lang: ger
text: "Wissen Sie, was sich hinter künstlicher Intelligenz und maschinellem Lernen
verbirgt? \r\nDieses Sachbuch erklärt Ihnen leicht verständlich und ohne komplizierte
Formeln die grundlegenden Methoden und Vorgehensweisen des maschinellen Lernens.
Mathematisches Vorwissen ist dafür nicht nötig. Kurzweilig und informativ illustriert
Lisa, die Protagonistin des Buches, diese anhand von Alltagssituationen. \r\nEin
Buch für alle, die in Diskussionen über Chancen und Risiken der aktuellen Entwicklung
der künstlichen Intelligenz und des maschinellen Lernens mit Faktenwissen punkten
möchten. Auch für Schülerinnen und Schüler geeignet!"
article_processing_charge: No
citation:
ama: 'Kersting K, Lampert C, Rothkopf C, eds. Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden: Springer Nature; 2019.
doi:10.1007/978-3-658-26763-6'
apa: 'Kersting, K., Lampert, C., & Rothkopf, C. (Eds.). (2019). Wie Maschinen
Lernen: Künstliche Intelligenz Verständlich Erklärt (1st ed.). Wiesbaden:
Springer Nature. https://doi.org/10.1007/978-3-658-26763-6'
chicago: 'Kersting, Kristian, Christoph Lampert, and Constantin Rothkopf, eds. Wie
Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden:
Springer Nature, 2019. https://doi.org/10.1007/978-3-658-26763-6.'
ieee: 'K. Kersting, C. Lampert, and C. Rothkopf, Eds., Wie Maschinen Lernen:
Künstliche Intelligenz Verständlich Erklärt, 1st ed. Wiesbaden: Springer Nature,
2019.'
ista: 'Kersting K, Lampert C, Rothkopf C eds. 2019. Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt 1st ed., Wiesbaden: Springer Nature, XIV, 245p.'
mla: 'Kersting, Kristian, et al., editors. Wie Maschinen Lernen: Künstliche Intelligenz
Verständlich Erklärt. 1st ed., Springer Nature, 2019, doi:10.1007/978-3-658-26763-6.'
short: 'K. Kersting, C. Lampert, C. Rothkopf, eds., Wie Maschinen Lernen: Künstliche
Intelligenz Verständlich Erklärt, 1st ed., Springer Nature, Wiesbaden, 2019.'
date_created: 2019-12-11T14:15:56Z
date_published: 2019-10-30T00:00:00Z
date_updated: 2021-12-22T14:40:58Z
day: '30'
department:
- _id: ChLa
doi: 10.1007/978-3-658-26763-6
edition: '1'
editor:
- first_name: Kristian
full_name: Kersting, Kristian
last_name: Kersting
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Constantin
full_name: Rothkopf, Constantin
last_name: Rothkopf
language:
- iso: ger
month: '10'
oa_version: None
page: XIV, 245
place: Wiesbaden
publication_identifier:
eisbn:
- 978-3-658-26763-6
isbn:
- 978-3-658-26762-9
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/book-release-how-machines-learn/
status: public
title: 'Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt'
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
_id: '7275'
abstract:
- lang: eng
text: Aprotic alkali metal–oxygen batteries require reversible formation of metal
superoxide or peroxide on cycling. Severe parasitic reactions cause poor rechargeability,
efficiency, and cycle life and have been shown to be caused by singlet oxygen
(1O2) that forms at all stages of cycling. However, its formation mechanism remains
unclear. We show that disproportionation of superoxide, the product or intermediate
on discharge and charge, to peroxide and oxygen is responsible for 1O2 formation.
While the overall reaction is driven by the stability of peroxide and thus favored
by stronger Lewis acidic cations such as Li+, the 1O2 fraction is enhanced by
weak Lewis acids such as organic cations. Concurrently, the metal peroxide yield
drops with increasing 1O2. The results explain a major parasitic pathway during
cell cycling and the growing severity in K–, Na–, and Li–O2 cells based on the
growing propensity for disproportionation. High capacities and rates with peroxides
are now realized to require solution processes, which form peroxide or release
O2via disproportionation. The results therefore establish the central dilemma
that disproportionation is required for high capacity but also responsible for
irreversible reactions. Highly reversible cell operation requires hence finding
reaction routes that avoid disproportionation.
article_processing_charge: No
article_type: original
author:
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Riccardo
full_name: Spezia, Riccardo
last_name: Spezia
- first_name: Aleksej
full_name: Samojlov, Aleksej
last_name: Samojlov
- first_name: Francesco F.
full_name: Summa, Francesco F.
last_name: Summa
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
- first_name: Sergio
full_name: Brutti, Sergio
last_name: Brutti
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Mourad E, Petit YK, Spezia R, et al. Singlet oxygen from cation driven superoxide
disproportionation and consequences for aprotic metal–O2 batteries. Energy
& Environmental Science. 2019;12(8):2559-2568. doi:10.1039/c9ee01453e
apa: Mourad, E., Petit, Y. K., Spezia, R., Samojlov, A., Summa, F. F., Prehal, C.,
… Freunberger, S. A. (2019). Singlet oxygen from cation driven superoxide disproportionation
and consequences for aprotic metal–O2 batteries. Energy & Environmental
Science. RSC. https://doi.org/10.1039/c9ee01453e
chicago: Mourad, Eléonore, Yann K. Petit, Riccardo Spezia, Aleksej Samojlov, Francesco
F. Summa, Christian Prehal, Christian Leypold, et al. “Singlet Oxygen from Cation
Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.”
Energy & Environmental Science. RSC, 2019. https://doi.org/10.1039/c9ee01453e.
ieee: E. Mourad et al., “Singlet oxygen from cation driven superoxide disproportionation
and consequences for aprotic metal–O2 batteries,” Energy & Environmental
Science, vol. 12, no. 8. RSC, pp. 2559–2568, 2019.
ista: Mourad E, Petit YK, Spezia R, Samojlov A, Summa FF, Prehal C, Leypold C, Mahne
N, Slugovc C, Fontaine O, Brutti S, Freunberger SA. 2019. Singlet oxygen from
cation driven superoxide disproportionation and consequences for aprotic metal–O2
batteries. Energy & Environmental Science. 12(8), 2559–2568.
mla: Mourad, Eléonore, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation
and Consequences for Aprotic Metal–O2 Batteries.” Energy & Environmental
Science, vol. 12, no. 8, RSC, 2019, pp. 2559–68, doi:10.1039/c9ee01453e.
short: E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C.
Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy
& Environmental Science 12 (2019) 2559–2568.
date_created: 2020-01-15T07:18:04Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:12:41Z
day: '01'
ddc:
- '530'
- '541'
- '540'
doi: 10.1039/c9ee01453e
extern: '1'
file:
- access_level: open_access
checksum: 94d4cfb2ab0b4c90ef76a7f3cc811feb
content_type: application/pdf
creator: dernst
date_created: 2020-01-30T16:11:05Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7424'
file_name: 2019_EnergyEnvironScienc_Mourad.pdf
file_size: 2888027
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: 2559-2568
publication: Energy & Environmental Science
publication_identifier:
issn:
- 1754-5692
- 1754-5706
publication_status: published
publisher: RSC
quality_controlled: '1'
status: public
title: Singlet oxygen from cation driven superoxide disproportionation and consequences
for aprotic metal–O2 batteries
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...
---
_id: '7280'
abstract:
- lang: eng
text: Non-aqueous lithium-oxygen batteries cycle by forming lithium peroxide during
discharge and oxidizing it during recharge. The significant problem of oxidizing
the solid insulating lithium peroxide can greatly be facilitated by incorporating
redox mediators that shuttle electron-holes between the porous substrate and lithium
peroxide. Redox mediator stability is thus key for energy efficiency, reversibility,
and cycle life. However, the gradual deactivation of redox mediators during repeated
cycling has not conclusively been explained. Here, we show that organic redox
mediators are predominantly decomposed by singlet oxygen that forms during cycling.
Their reaction with superoxide, previously assumed to mainly trigger their degradation,
peroxide, and dioxygen, is orders of magnitude slower in comparison. The reduced
form of the mediator is markedly more reactive towards singlet oxygen than the
oxidized form, from which we derive reaction mechanisms supported by density functional
theory calculations. Redox mediators must thus be designed for stability against
singlet oxygen.
article_number: '1380'
article_processing_charge: No
article_type: original
author:
- first_name: Won-Jin
full_name: Kwak, Won-Jin
last_name: Kwak
- first_name: Hun
full_name: Kim, Hun
last_name: Kim
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Trung Thien
full_name: Nguyen, Trung Thien
last_name: Nguyen
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Paul
full_name: Redfern, Paul
last_name: Redfern
- first_name: Larry A.
full_name: Curtiss, Larry A.
last_name: Curtiss
- first_name: Hun-Gi
full_name: Jung, Hun-Gi
last_name: Jung
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Yang-Kook
full_name: Sun, Yang-Kook
last_name: Sun
citation:
ama: Kwak W-J, Kim H, Petit YK, et al. Deactivation of redox mediators in lithium-oxygen
batteries by singlet oxygen. Nature Communications. 2019;10. doi:10.1038/s41467-019-09399-0
apa: Kwak, W.-J., Kim, H., Petit, Y. K., Leypold, C., Nguyen, T. T., Mahne, N.,
… Sun, Y.-K. (2019). Deactivation of redox mediators in lithium-oxygen batteries
by singlet oxygen. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-019-09399-0
chicago: Kwak, Won-Jin, Hun Kim, Yann K. Petit, Christian Leypold, Trung Thien Nguyen,
Nika Mahne, Paul Redfern, et al. “Deactivation of Redox Mediators in Lithium-Oxygen
Batteries by Singlet Oxygen.” Nature Communications. Springer Nature, 2019.
https://doi.org/10.1038/s41467-019-09399-0.
ieee: W.-J. Kwak et al., “Deactivation of redox mediators in lithium-oxygen
batteries by singlet oxygen,” Nature Communications, vol. 10. Springer
Nature, 2019.
ista: Kwak W-J, Kim H, Petit YK, Leypold C, Nguyen TT, Mahne N, Redfern P, Curtiss
LA, Jung H-G, Borisov SM, Freunberger SA, Sun Y-K. 2019. Deactivation of redox
mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications.
10, 1380.
mla: Kwak, Won-Jin, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries
by Singlet Oxygen.” Nature Communications, vol. 10, 1380, Springer Nature,
2019, doi:10.1038/s41467-019-09399-0.
short: W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern,
L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications
10 (2019).
date_created: 2020-01-15T12:12:26Z
date_published: 2019-03-26T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '26'
ddc:
- '540'
doi: 10.1038/s41467-019-09399-0
extern: '1'
file:
- access_level: open_access
checksum: 123dd33e7f26761c82c74e10811a1e4d
content_type: application/pdf
creator: dernst
date_created: 2020-01-22T15:58:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7355'
file_name: 2019_NatureComm_Kwak.pdf
file_size: 1003676
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 10'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2019'
...
---
_id: '7276'
abstract:
- lang: eng
text: Singlet oxygen (1O2) causes a major fraction of the parasitic chemistry during
the cycling of non‐aqueous alkali metal‐O2 batteries and also contributes to interfacial
reactivity of transition‐metal oxide intercalation compounds. We introduce DABCOnium,
the mono alkylated form of 1,4‐diazabicyclo[2.2.2]octane (DABCO), as an efficient
1O2 quencher with an unusually high oxidative stability of ca. 4.2 V vs. Li/Li+.
Previous quenchers are strongly Lewis basic amines with too low oxidative stability.
DABCOnium is an ionic liquid, non‐volatile, highly soluble in the electrolyte,
stable against superoxide and peroxide, and compatible with lithium metal. The
electrochemical stability covers the required range for metal–O2 batteries and
greatly reduces 1O2 related parasitic chemistry as demonstrated for the Li–O2
cell.
article_processing_charge: No
article_type: original
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Nika
full_name: Mahne, Nika
last_name: Mahne
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Lukas
full_name: Schafzahl, Lukas
last_name: Schafzahl
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: 'Petit YK, Leypold C, Mahne N, et al. DABCOnium: An efficient and high-voltage
stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International
Edition. 2019;58(20):6535-6539. doi:10.1002/anie.201901869'
apa: 'Petit, Y. K., Leypold, C., Mahne, N., Mourad, E., Schafzahl, L., Slugovc,
C., … Freunberger, S. A. (2019). DABCOnium: An efficient and high-voltage stable
singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International
Edition. Wiley. https://doi.org/10.1002/anie.201901869'
chicago: 'Petit, Yann K., Christian Leypold, Nika Mahne, Eléonore Mourad, Lukas
Schafzahl, Christian Slugovc, Sergey M. Borisov, and Stefan Alexander Freunberger.
“DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2
Cells.” Angewandte Chemie International Edition. Wiley, 2019. https://doi.org/10.1002/anie.201901869.'
ieee: 'Y. K. Petit et al., “DABCOnium: An efficient and high-voltage stable
singlet oxygen quencher for metal-O2 cells,” Angewandte Chemie International
Edition, vol. 58, no. 20. Wiley, pp. 6535–6539, 2019.'
ista: 'Petit YK, Leypold C, Mahne N, Mourad E, Schafzahl L, Slugovc C, Borisov SM,
Freunberger SA. 2019. DABCOnium: An efficient and high-voltage stable singlet
oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. 58(20),
6535–6539.'
mla: 'Petit, Yann K., et al. “DABCOnium: An Efficient and High-Voltage Stable Singlet
Oxygen Quencher for Metal-O2 Cells.” Angewandte Chemie International Edition,
vol. 58, no. 20, Wiley, 2019, pp. 6535–39, doi:10.1002/anie.201901869.'
short: Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M.
Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539.
date_created: 2020-01-15T07:19:27Z
date_published: 2019-05-13T00:00:00Z
date_updated: 2021-01-12T08:12:42Z
day: '13'
ddc:
- '540'
doi: 10.1002/anie.201901869
extern: '1'
file:
- access_level: open_access
checksum: 9620b6a511a910d7abe1f26c42dc7f83
content_type: application/pdf
creator: dernst
date_created: 2020-01-22T16:16:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7356'
file_name: 2019_AngewChemie_Petit.pdf
file_size: 952737
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 58'
issue: '20'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 6535-6539
publication: Angewandte Chemie International Edition
publication_identifier:
issn:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for
metal-O2 cells'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2019'
...
---
_id: '7281'
abstract:
- lang: eng
text: Li–O2 batteries are plagued by side reactions that cause poor rechargeability
and efficiency. These reactions were recently revealed to be predominantly caused
by singlet oxygen, which can be neutralized by chemical traps or physical quenchers.
However, traps are irreversibly consumed and thus only active for a limited time,
and so far identified quenchers lack oxidative stability to be suitable for typically
required recharge potentials. Thus, reducing the charge potential within the stability
limit of the quencher and/or finding more stable quenchers is required. Here,
we show that dimethylphenazine as a redox mediator decreases the charge potential
well within the stability limit of the quencher 1,4-diazabicyclo[2.2.2]octane.
The quencher can thus mitigate the parasitic reactions without being oxidatively
decomposed. At the same time the quencher protects the redox mediator from singlet
oxygen attack. The mutual conservation of the redox mediator and the quencher
is rational for stable and effective Li–O2 batteries.
article_processing_charge: No
article_type: original
author:
- first_name: Won-Jin
full_name: Kwak, Won-Jin
last_name: Kwak
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Hun
full_name: Kim, Hun
last_name: Kim
- first_name: Jiwon
full_name: Park, Jiwon
last_name: Park
- first_name: Trung Thien
full_name: Nguyen, Trung Thien
last_name: Nguyen
- first_name: Hun-Gi
full_name: Jung, Hun-Gi
last_name: Jung
- first_name: Hye Ryung
full_name: Byon, Hye Ryung
last_name: Byon
- first_name: Yang-Kook
full_name: Sun, Yang-Kook
last_name: Sun
citation:
ama: Kwak W-J, Freunberger SA, Kim H, et al. Mutual conservation of redox mediator
and singlet oxygen quencher in Lithium–Oxygen batteries. ACS Catalysis.
2019;9(11):9914-9922. doi:10.1021/acscatal.9b01337
apa: Kwak, W.-J., Freunberger, S. A., Kim, H., Park, J., Nguyen, T. T., Jung, H.-G.,
… Sun, Y.-K. (2019). Mutual conservation of redox mediator and singlet oxygen
quencher in Lithium–Oxygen batteries. ACS Catalysis. ACS. https://doi.org/10.1021/acscatal.9b01337
chicago: Kwak, Won-Jin, Stefan Alexander Freunberger, Hun Kim, Jiwon Park, Trung
Thien Nguyen, Hun-Gi Jung, Hye Ryung Byon, and Yang-Kook Sun. “Mutual Conservation
of Redox Mediator and Singlet Oxygen Quencher in Lithium–Oxygen Batteries.” ACS
Catalysis. ACS, 2019. https://doi.org/10.1021/acscatal.9b01337.
ieee: W.-J. Kwak et al., “Mutual conservation of redox mediator and singlet
oxygen quencher in Lithium–Oxygen batteries,” ACS Catalysis, vol. 9, no.
11. ACS, pp. 9914–9922, 2019.
ista: Kwak W-J, Freunberger SA, Kim H, Park J, Nguyen TT, Jung H-G, Byon HR, Sun
Y-K. 2019. Mutual conservation of redox mediator and singlet oxygen quencher in
Lithium–Oxygen batteries. ACS Catalysis. 9(11), 9914–9922.
mla: Kwak, Won-Jin, et al. “Mutual Conservation of Redox Mediator and Singlet Oxygen
Quencher in Lithium–Oxygen Batteries.” ACS Catalysis, vol. 9, no. 11, ACS,
2019, pp. 9914–22, doi:10.1021/acscatal.9b01337.
short: W.-J. Kwak, S.A. Freunberger, H. Kim, J. Park, T.T. Nguyen, H.-G. Jung, H.R.
Byon, Y.-K. Sun, ACS Catalysis 9 (2019) 9914–9922.
date_created: 2020-01-15T12:12:40Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '01'
ddc:
- '540'
doi: 10.1021/acscatal.9b01337
extern: '1'
file:
- access_level: open_access
checksum: bbaebfe5ff0bcab6235821ba3460b7de
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T15:19:30Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8053'
file_name: Revised Manuscript.pdf
file_size: 1199086
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 9'
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 9914-9922
publication: ACS Catalysis
publication_identifier:
issn:
- 2155-5435
publication_status: published
publisher: ACS
quality_controlled: '1'
status: public
title: Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen
batteries
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2019'
...
---
_id: '7282'
abstract:
- lang: eng
text: Interphases that form on the anode surface of lithium-ion batteries are critical
for performance and lifetime, but are poorly understood. Now, a decade-old misconception
regarding a main component of the interphase has been revealed, which could potentially
lead to improved devices.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Freunberger SA. Interphase identity crisis. Nature Chemistry. 2019;11(9):761-763.
doi:10.1038/s41557-019-0311-0
apa: Freunberger, S. A. (2019). Interphase identity crisis. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/s41557-019-0311-0
chicago: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature
Chemistry. Springer Nature, 2019. https://doi.org/10.1038/s41557-019-0311-0.
ieee: S. A. Freunberger, “Interphase identity crisis,” Nature Chemistry,
vol. 11, no. 9. Springer Nature, pp. 761–763, 2019.
ista: Freunberger SA. 2019. Interphase identity crisis. Nature Chemistry. 11(9),
761–763.
mla: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature Chemistry,
vol. 11, no. 9, Springer Nature, 2019, pp. 761–63, doi:10.1038/s41557-019-0311-0.
short: S.A. Freunberger, Nature Chemistry 11 (2019) 761–763.
date_created: 2020-01-15T12:12:53Z
date_published: 2019-08-19T00:00:00Z
date_updated: 2021-01-12T08:12:44Z
day: '19'
ddc:
- '540'
- '547'
doi: 10.1038/s41557-019-0311-0
extern: '1'
file:
- access_level: open_access
checksum: 76806cff3d5b62f846499a8617cee7ef
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T15:38:21Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8054'
file_name: Freunberger on Eichhorn.pdf
file_size: 286805
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '9'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 761-763
publication: Nature Chemistry
publication_identifier:
issn:
- 1755-4330
- 1755-4349
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Interphase identity crisis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...
---
_id: '7283'
abstract:
- lang: eng
text: Potassium–air batteries, which suffer from oxygen cathode and potassium metal
anode degradation, can be cycled thousands of times when an organic anode replaces
the metal.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Petit YK, Freunberger SA. Thousands of cycles. Nature Materials. 2019;18(4):301-302.
doi:10.1038/s41563-019-0313-8
apa: Petit, Y. K., & Freunberger, S. A. (2019). Thousands of cycles. Nature
Materials. Springer Nature. https://doi.org/10.1038/s41563-019-0313-8
chicago: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.”
Nature Materials. Springer Nature, 2019. https://doi.org/10.1038/s41563-019-0313-8.
ieee: Y. K. Petit and S. A. Freunberger, “Thousands of cycles,” Nature Materials,
vol. 18, no. 4. Springer Nature, pp. 301–302, 2019.
ista: Petit YK, Freunberger SA. 2019. Thousands of cycles. Nature Materials. 18(4),
301–302.
mla: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.” Nature
Materials, vol. 18, no. 4, Springer Nature, 2019, pp. 301–02, doi:10.1038/s41563-019-0313-8.
short: Y.K. Petit, S.A. Freunberger, Nature Materials 18 (2019) 301–302.
date_created: 2020-01-15T12:13:05Z
date_published: 2019-03-20T00:00:00Z
date_updated: 2021-01-12T08:12:45Z
day: '20'
ddc:
- '540'
- '541'
doi: 10.1038/s41563-019-0313-8
extern: '1'
file:
- access_level: open_access
checksum: 4c9a0314327028a22dd902bc109b8798
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T16:26:54Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8059'
file_name: NaV_final.pdf
file_size: 398123
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 18'
issue: '4'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 301-302
publication: Nature Materials
publication_identifier:
issn:
- 1476-1122
- 1476-4660
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Thousands of cycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2019'
...