--- _id: '7128' abstract: - lang: eng text: Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate cardiac regeneration in mice. Here, we show that all of the most effective of these miRNAs activate nuclear localization of the master transcriptional cofactor Yes-associated protein (YAP) and induce expression of YAP-responsive genes. In particular, miR-199a-3p directly targets two mRNAs coding for proteins impinging on the Hippo pathway, the upstream YAP inhibitory kinase TAOK1, and the E3 ubiquitin ligase β-TrCP, which leads to YAP degradation. Several of the pro-proliferative miRNAs (including miR-199a-3p) also inhibit filamentous actin depolymerization by targeting Cofilin2, a process that by itself activates YAP nuclear translocation. Thus, activation of YAP and modulation of the actin cytoskeleton are major components of the pro-proliferative action of miR-199a-3p and other miRNAs that induce cardiomyocyte proliferation. article_processing_charge: Yes article_type: original author: - first_name: Consuelo full_name: Torrini, Consuelo last_name: Torrini - first_name: Ryan J full_name: Cubero, Ryan J id: 850B2E12-9CD4-11E9-837F-E719E6697425 last_name: Cubero orcid: 0000-0003-0002-1867 - first_name: Ellen full_name: Dirkx, Ellen last_name: Dirkx - first_name: Luca full_name: Braga, Luca last_name: Braga - first_name: Hashim full_name: Ali, Hashim last_name: Ali - first_name: Giulia full_name: Prosdocimo, Giulia last_name: Prosdocimo - first_name: Maria Ines full_name: Gutierrez, Maria Ines last_name: Gutierrez - first_name: Chiara full_name: Collesi, Chiara last_name: Collesi - first_name: Danilo full_name: Licastro, Danilo last_name: Licastro - first_name: Lorena full_name: Zentilin, Lorena last_name: Zentilin - first_name: Miguel full_name: Mano, Miguel last_name: Mano - first_name: Serena full_name: Zacchigna, Serena last_name: Zacchigna - first_name: Michele full_name: Vendruscolo, Michele last_name: Vendruscolo - first_name: Matteo full_name: Marsili, Matteo last_name: Marsili - first_name: Areejit full_name: Samal, Areejit last_name: Samal - first_name: Mauro full_name: Giacca, Mauro last_name: Giacca citation: ama: Torrini C, Cubero RJ, Dirkx E, et al. Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation. Cell Reports. 2019;27(9):2759-2771.e5. doi:10.1016/j.celrep.2019.05.005 apa: Torrini, C., Cubero, R. J., Dirkx, E., Braga, L., Ali, H., Prosdocimo, G., … Giacca, M. (2019). Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2019.05.005 chicago: Torrini, Consuelo, Ryan J Cubero, Ellen Dirkx, Luca Braga, Hashim Ali, Giulia Prosdocimo, Maria Ines Gutierrez, et al. “Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.” Cell Reports. Elsevier, 2019. https://doi.org/10.1016/j.celrep.2019.05.005. ieee: C. Torrini et al., “Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation,” Cell Reports, vol. 27, no. 9. Elsevier, p. 2759–2771.e5, 2019. ista: Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI, Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili M, Samal A, Giacca M. 2019. Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation. Cell Reports. 27(9), 2759–2771.e5. mla: Torrini, Consuelo, et al. “Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.” Cell Reports, vol. 27, no. 9, Elsevier, 2019, p. 2759–2771.e5, doi:10.1016/j.celrep.2019.05.005. short: C. Torrini, R.J. Cubero, E. Dirkx, L. Braga, H. Ali, G. Prosdocimo, M.I. Gutierrez, C. Collesi, D. Licastro, L. Zentilin, M. Mano, S. Zacchigna, M. Vendruscolo, M. Marsili, A. Samal, M. Giacca, Cell Reports 27 (2019) 2759–2771.e5. date_created: 2019-11-26T22:30:07Z date_published: 2019-05-28T00:00:00Z date_updated: 2021-01-12T08:11:56Z day: '28' ddc: - '576' doi: 10.1016/j.celrep.2019.05.005 extern: '1' external_id: pmid: - '31141697' file: - access_level: open_access checksum: c5d855d07263bfec718673385d0ea2d7 content_type: application/pdf creator: rcubero date_created: 2019-11-26T22:30:43Z date_updated: 2020-07-14T12:47:50Z file_id: '7129' file_name: torrini_cellreports_2019.pdf file_size: 4650750 relation: main_file file_date_updated: 2020-07-14T12:47:50Z has_accepted_license: '1' intvolume: ' 27' issue: '9' keyword: - cardiomyocyte - cell cycle - Cofilin2 - cytoskeleton - Hippo - microRNA - regeneration - YAP language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: 2759-2771.e5 pmid: 1 publication: Cell Reports publication_identifier: issn: - 2211-1247 publication_status: published publisher: Elsevier quality_controlled: '1' status: public title: Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 27 year: '2019' ... --- _id: '7130' abstract: - lang: eng text: "We show that statistical criticality, i.e. the occurrence of power law frequency distributions, arises in samples that are maximally informative about the underlying generating process. In order to reach this conclusion, we first identify the frequency with which different outcomes occur in a sample, as the variable carrying useful information on the generative process. The entropy of the frequency, that we call relevance, provides an upper bound to the number of informative bits. This differs from the entropy of the data, that we take as a measure of resolution. Samples that maximise relevance at a given resolution—that we call maximally informative samples—exhibit statistical criticality. In particular, Zipf's law arises at the optimal trade-off between resolution (i.e. compression) and relevance. As a byproduct, we derive a bound of the maximal number of parameters that can be estimated from a dataset, in the absence of prior knowledge on the generative model.\r\n\r\nFurthermore, we relate criticality to the statistical properties of the representation of the data generating process. We show that, as a consequence of the concentration property of the asymptotic equipartition property, representations that are maximally informative about the data generating process are characterised by an exponential distribution of energy levels. This arises from a principle of minimal entropy, that is conjugate of the maximum entropy principle in statistical mechanics. This explains why statistical criticality requires no parameter fine tuning in maximally informative samples." acknowledgement: We acknowledge interesting discussions with M Abbott, E Aurell, J Barbier, R Monasson, T Mora, I Nemenman, N Tishby and R Zecchina. This research was supported by the Kavli Foundation and the Centre of Excellence scheme of the Research Council of Norway (Centre for Neural Computation) (RJC and YR), by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2016R1D1A1B03932264) (JJ), and, in part, by the ICTP through the OEA-AC-98 (JS). article_number: '063402' article_processing_charge: No article_type: original author: - first_name: Ryan J full_name: Cubero, Ryan J id: 850B2E12-9CD4-11E9-837F-E719E6697425 last_name: Cubero orcid: 0000-0003-0002-1867 - first_name: Junghyo full_name: Jo, Junghyo last_name: Jo - first_name: Matteo full_name: Marsili, Matteo last_name: Marsili - first_name: Yasser full_name: Roudi, Yasser last_name: Roudi - first_name: Juyong full_name: Song, Juyong last_name: Song citation: ama: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. Statistical criticality arises in most informative representations. Journal of Statistical Mechanics: Theory and Experiment. 2019;2019(6). doi:10.1088/1742-5468/ab16c8' apa: 'Cubero, R. J., Jo, J., Marsili, M., Roudi, Y., & Song, J. (2019). Statistical criticality arises in most informative representations. Journal of Statistical Mechanics: Theory and Experiment. IOP Publishing. https://doi.org/10.1088/1742-5468/ab16c8' chicago: 'Cubero, Ryan J, Junghyo Jo, Matteo Marsili, Yasser Roudi, and Juyong Song. “Statistical Criticality Arises in Most Informative Representations.” Journal of Statistical Mechanics: Theory and Experiment. IOP Publishing, 2019. https://doi.org/10.1088/1742-5468/ab16c8.' ieee: 'R. J. Cubero, J. Jo, M. Marsili, Y. Roudi, and J. Song, “Statistical criticality arises in most informative representations,” Journal of Statistical Mechanics: Theory and Experiment, vol. 2019, no. 6. IOP Publishing, 2019.' ista: 'Cubero RJ, Jo J, Marsili M, Roudi Y, Song J. 2019. Statistical criticality arises in most informative representations. Journal of Statistical Mechanics: Theory and Experiment. 2019(6), 063402.' mla: 'Cubero, Ryan J., et al. “Statistical Criticality Arises in Most Informative Representations.” Journal of Statistical Mechanics: Theory and Experiment, vol. 2019, no. 6, 063402, IOP Publishing, 2019, doi:10.1088/1742-5468/ab16c8.' short: 'R.J. Cubero, J. Jo, M. Marsili, Y. Roudi, J. Song, Journal of Statistical Mechanics: Theory and Experiment 2019 (2019).' date_created: 2019-11-26T22:36:09Z date_published: 2019-06-17T00:00:00Z date_updated: 2021-01-12T08:11:57Z day: '17' doi: 10.1088/1742-5468/ab16c8 extern: '1' external_id: arxiv: - '1808.00249' intvolume: ' 2019' issue: '6' keyword: - optimization under uncertainty - source coding - large deviation language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1808.00249 month: '06' oa: 1 oa_version: Preprint publication: 'Journal of Statistical Mechanics: Theory and Experiment' publication_identifier: issn: - 1742-5468 publication_status: published publisher: IOP Publishing quality_controlled: '1' status: public title: Statistical criticality arises in most informative representations type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 2019 year: '2019' ... --- _id: '7150' abstract: - lang: eng text: "In this work, we use algebraic methods for studying distance computation and subgraph detection tasks in the congested clique model. Specifically, we adapt parallel matrix multiplication implementations to the congested clique, obtaining an O(n1−2/ω) round matrix multiplication algorithm, where ω<2.3728639 is the exponent of matrix multiplication. In conjunction with known techniques from centralised algorithmics, this gives significant improvements over previous best upper bounds in the congested clique model. The highlight results include:\r\n\r\n1. triangle and 4-cycle counting in O(n0.158) rounds, improving upon the O(n1/3) algorithm of Dolev et al. [DISC 2012],\r\n2. a (1+o(1))-approximation of all-pairs shortest paths in O(n0.158) rounds, improving upon the O~(n1/2)-round (2+o(1))-approximation algorithm given by Nanongkai [STOC 2014], and\r\n 3. computing the girth in O(n0.158) rounds, which is the first non-trivial solution in this model.\r\n \r\nIn addition, we present a novel constant-round combinatorial algorithm for detecting 4-cycles." article_processing_charge: No article_type: original author: - first_name: Keren full_name: Censor-Hillel, Keren last_name: Censor-Hillel - first_name: Petteri full_name: Kaski, Petteri last_name: Kaski - first_name: Janne full_name: Korhonen, Janne id: C5402D42-15BC-11E9-A202-CA2BE6697425 last_name: Korhonen - first_name: Christoph full_name: Lenzen, Christoph last_name: Lenzen - first_name: Ami full_name: Paz, Ami last_name: Paz - first_name: Jukka full_name: Suomela, Jukka last_name: Suomela citation: ama: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. Algebraic methods in the congested clique. Distributed Computing. 2019;32(6):461-478. doi:10.1007/s00446-016-0270-2 apa: Censor-Hillel, K., Kaski, P., Korhonen, J., Lenzen, C., Paz, A., & Suomela, J. (2019). Algebraic methods in the congested clique. Distributed Computing. Springer Nature. https://doi.org/10.1007/s00446-016-0270-2 chicago: Censor-Hillel, Keren, Petteri Kaski, Janne Korhonen, Christoph Lenzen, Ami Paz, and Jukka Suomela. “Algebraic Methods in the Congested Clique.” Distributed Computing. Springer Nature, 2019. https://doi.org/10.1007/s00446-016-0270-2. ieee: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, and J. Suomela, “Algebraic methods in the congested clique,” Distributed Computing, vol. 32, no. 6. Springer Nature, pp. 461–478, 2019. ista: Censor-Hillel K, Kaski P, Korhonen J, Lenzen C, Paz A, Suomela J. 2019. Algebraic methods in the congested clique. Distributed Computing. 32(6), 461–478. mla: Censor-Hillel, Keren, et al. “Algebraic Methods in the Congested Clique.” Distributed Computing, vol. 32, no. 6, Springer Nature, 2019, pp. 461–78, doi:10.1007/s00446-016-0270-2. short: K. Censor-Hillel, P. Kaski, J. Korhonen, C. Lenzen, A. Paz, J. Suomela, Distributed Computing 32 (2019) 461–478. date_created: 2019-12-05T09:49:49Z date_published: 2019-12-01T00:00:00Z date_updated: 2021-01-12T08:12:05Z day: '01' doi: 10.1007/s00446-016-0270-2 extern: '1' external_id: arxiv: - '1503.04963' intvolume: ' 32' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/1503.04963 month: '12' oa: 1 oa_version: Preprint page: 461-478 publication: Distributed Computing publication_identifier: issn: - 0178-2770 - 1432-0452 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Algebraic methods in the congested clique type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 32 year: '2019' ... --- _id: '7171' abstract: - lang: ger text: "Wissen Sie, was sich hinter künstlicher Intelligenz und maschinellem Lernen verbirgt? \r\nDieses Sachbuch erklärt Ihnen leicht verständlich und ohne komplizierte Formeln die grundlegenden Methoden und Vorgehensweisen des maschinellen Lernens. Mathematisches Vorwissen ist dafür nicht nötig. Kurzweilig und informativ illustriert Lisa, die Protagonistin des Buches, diese anhand von Alltagssituationen. \r\nEin Buch für alle, die in Diskussionen über Chancen und Risiken der aktuellen Entwicklung der künstlichen Intelligenz und des maschinellen Lernens mit Faktenwissen punkten möchten. Auch für Schülerinnen und Schüler geeignet!" article_processing_charge: No citation: ama: 'Kersting K, Lampert C, Rothkopf C, eds. Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden: Springer Nature; 2019. doi:10.1007/978-3-658-26763-6' apa: 'Kersting, K., Lampert, C., & Rothkopf, C. (Eds.). (2019). Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt (1st ed.). Wiesbaden: Springer Nature. https://doi.org/10.1007/978-3-658-26763-6' chicago: 'Kersting, Kristian, Christoph Lampert, and Constantin Rothkopf, eds. Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt. 1st ed. Wiesbaden: Springer Nature, 2019. https://doi.org/10.1007/978-3-658-26763-6.' ieee: 'K. Kersting, C. Lampert, and C. Rothkopf, Eds., Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt, 1st ed. Wiesbaden: Springer Nature, 2019.' ista: 'Kersting K, Lampert C, Rothkopf C eds. 2019. Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt 1st ed., Wiesbaden: Springer Nature, XIV, 245p.' mla: 'Kersting, Kristian, et al., editors. Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt. 1st ed., Springer Nature, 2019, doi:10.1007/978-3-658-26763-6.' short: 'K. Kersting, C. Lampert, C. Rothkopf, eds., Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt, 1st ed., Springer Nature, Wiesbaden, 2019.' date_created: 2019-12-11T14:15:56Z date_published: 2019-10-30T00:00:00Z date_updated: 2021-12-22T14:40:58Z day: '30' department: - _id: ChLa doi: 10.1007/978-3-658-26763-6 edition: '1' editor: - first_name: Kristian full_name: Kersting, Kristian last_name: Kersting - first_name: Christoph full_name: Lampert, Christoph id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 - first_name: Constantin full_name: Rothkopf, Constantin last_name: Rothkopf language: - iso: ger month: '10' oa_version: None page: XIV, 245 place: Wiesbaden publication_identifier: eisbn: - 978-3-658-26763-6 isbn: - 978-3-658-26762-9 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on IST Website relation: press_release url: https://ist.ac.at/en/news/book-release-how-machines-learn/ status: public title: 'Wie Maschinen Lernen: Künstliche Intelligenz Verständlich Erklärt' type: book_editor user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2019' ... --- _id: '7275' abstract: - lang: eng text: Aprotic alkali metal–oxygen batteries require reversible formation of metal superoxide or peroxide on cycling. Severe parasitic reactions cause poor rechargeability, efficiency, and cycle life and have been shown to be caused by singlet oxygen (1O2) that forms at all stages of cycling. However, its formation mechanism remains unclear. We show that disproportionation of superoxide, the product or intermediate on discharge and charge, to peroxide and oxygen is responsible for 1O2 formation. While the overall reaction is driven by the stability of peroxide and thus favored by stronger Lewis acidic cations such as Li+, the 1O2 fraction is enhanced by weak Lewis acids such as organic cations. Concurrently, the metal peroxide yield drops with increasing 1O2. The results explain a major parasitic pathway during cell cycling and the growing severity in K–, Na–, and Li–O2 cells based on the growing propensity for disproportionation. High capacities and rates with peroxides are now realized to require solution processes, which form peroxide or release O2via disproportionation. The results therefore establish the central dilemma that disproportionation is required for high capacity but also responsible for irreversible reactions. Highly reversible cell operation requires hence finding reaction routes that avoid disproportionation. article_processing_charge: No article_type: original author: - first_name: Eléonore full_name: Mourad, Eléonore last_name: Mourad - first_name: Yann K. full_name: Petit, Yann K. last_name: Petit - first_name: Riccardo full_name: Spezia, Riccardo last_name: Spezia - first_name: Aleksej full_name: Samojlov, Aleksej last_name: Samojlov - first_name: Francesco F. full_name: Summa, Francesco F. last_name: Summa - first_name: Christian full_name: Prehal, Christian last_name: Prehal - first_name: Christian full_name: Leypold, Christian last_name: Leypold - first_name: Nika full_name: Mahne, Nika last_name: Mahne - first_name: Christian full_name: Slugovc, Christian last_name: Slugovc - first_name: Olivier full_name: Fontaine, Olivier last_name: Fontaine - first_name: Sergio full_name: Brutti, Sergio last_name: Brutti - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 citation: ama: Mourad E, Petit YK, Spezia R, et al. Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. Energy & Environmental Science. 2019;12(8):2559-2568. doi:10.1039/c9ee01453e apa: Mourad, E., Petit, Y. K., Spezia, R., Samojlov, A., Summa, F. F., Prehal, C., … Freunberger, S. A. (2019). Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. Energy & Environmental Science. RSC. https://doi.org/10.1039/c9ee01453e chicago: Mourad, Eléonore, Yann K. Petit, Riccardo Spezia, Aleksej Samojlov, Francesco F. Summa, Christian Prehal, Christian Leypold, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.” Energy & Environmental Science. RSC, 2019. https://doi.org/10.1039/c9ee01453e. ieee: E. Mourad et al., “Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries,” Energy & Environmental Science, vol. 12, no. 8. RSC, pp. 2559–2568, 2019. ista: Mourad E, Petit YK, Spezia R, Samojlov A, Summa FF, Prehal C, Leypold C, Mahne N, Slugovc C, Fontaine O, Brutti S, Freunberger SA. 2019. Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries. Energy & Environmental Science. 12(8), 2559–2568. mla: Mourad, Eléonore, et al. “Singlet Oxygen from Cation Driven Superoxide Disproportionation and Consequences for Aprotic Metal–O2 Batteries.” Energy & Environmental Science, vol. 12, no. 8, RSC, 2019, pp. 2559–68, doi:10.1039/c9ee01453e. short: E. Mourad, Y.K. Petit, R. Spezia, A. Samojlov, F.F. Summa, C. Prehal, C. Leypold, N. Mahne, C. Slugovc, O. Fontaine, S. Brutti, S.A. Freunberger, Energy & Environmental Science 12 (2019) 2559–2568. date_created: 2020-01-15T07:18:04Z date_published: 2019-08-01T00:00:00Z date_updated: 2021-01-12T08:12:41Z day: '01' ddc: - '530' - '541' - '540' doi: 10.1039/c9ee01453e extern: '1' file: - access_level: open_access checksum: 94d4cfb2ab0b4c90ef76a7f3cc811feb content_type: application/pdf creator: dernst date_created: 2020-01-30T16:11:05Z date_updated: 2020-07-14T12:47:55Z file_id: '7424' file_name: 2019_EnergyEnvironScienc_Mourad.pdf file_size: 2888027 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 12' issue: '8' language: - iso: eng license: https://creativecommons.org/licenses/by-nc/4.0/ month: '08' oa: 1 oa_version: Published Version page: 2559-2568 publication: Energy & Environmental Science publication_identifier: issn: - 1754-5692 - 1754-5706 publication_status: published publisher: RSC quality_controlled: '1' status: public title: Singlet oxygen from cation driven superoxide disproportionation and consequences for aprotic metal–O2 batteries tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2019' ... --- _id: '7280' abstract: - lang: eng text: Non-aqueous lithium-oxygen batteries cycle by forming lithium peroxide during discharge and oxidizing it during recharge. The significant problem of oxidizing the solid insulating lithium peroxide can greatly be facilitated by incorporating redox mediators that shuttle electron-holes between the porous substrate and lithium peroxide. Redox mediator stability is thus key for energy efficiency, reversibility, and cycle life. However, the gradual deactivation of redox mediators during repeated cycling has not conclusively been explained. Here, we show that organic redox mediators are predominantly decomposed by singlet oxygen that forms during cycling. Their reaction with superoxide, previously assumed to mainly trigger their degradation, peroxide, and dioxygen, is orders of magnitude slower in comparison. The reduced form of the mediator is markedly more reactive towards singlet oxygen than the oxidized form, from which we derive reaction mechanisms supported by density functional theory calculations. Redox mediators must thus be designed for stability against singlet oxygen. article_number: '1380' article_processing_charge: No article_type: original author: - first_name: Won-Jin full_name: Kwak, Won-Jin last_name: Kwak - first_name: Hun full_name: Kim, Hun last_name: Kim - first_name: Yann K. full_name: Petit, Yann K. last_name: Petit - first_name: Christian full_name: Leypold, Christian last_name: Leypold - first_name: Trung Thien full_name: Nguyen, Trung Thien last_name: Nguyen - first_name: Nika full_name: Mahne, Nika last_name: Mahne - first_name: Paul full_name: Redfern, Paul last_name: Redfern - first_name: Larry A. full_name: Curtiss, Larry A. last_name: Curtiss - first_name: Hun-Gi full_name: Jung, Hun-Gi last_name: Jung - first_name: Sergey M. full_name: Borisov, Sergey M. last_name: Borisov - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 - first_name: Yang-Kook full_name: Sun, Yang-Kook last_name: Sun citation: ama: Kwak W-J, Kim H, Petit YK, et al. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications. 2019;10. doi:10.1038/s41467-019-09399-0 apa: Kwak, W.-J., Kim, H., Petit, Y. K., Leypold, C., Nguyen, T. T., Mahne, N., … Sun, Y.-K. (2019). Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-019-09399-0 chicago: Kwak, Won-Jin, Hun Kim, Yann K. Petit, Christian Leypold, Trung Thien Nguyen, Nika Mahne, Paul Redfern, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” Nature Communications. Springer Nature, 2019. https://doi.org/10.1038/s41467-019-09399-0. ieee: W.-J. Kwak et al., “Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen,” Nature Communications, vol. 10. Springer Nature, 2019. ista: Kwak W-J, Kim H, Petit YK, Leypold C, Nguyen TT, Mahne N, Redfern P, Curtiss LA, Jung H-G, Borisov SM, Freunberger SA, Sun Y-K. 2019. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications. 10, 1380. mla: Kwak, Won-Jin, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” Nature Communications, vol. 10, 1380, Springer Nature, 2019, doi:10.1038/s41467-019-09399-0. short: W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern, L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications 10 (2019). date_created: 2020-01-15T12:12:26Z date_published: 2019-03-26T00:00:00Z date_updated: 2021-01-12T08:12:44Z day: '26' ddc: - '540' doi: 10.1038/s41467-019-09399-0 extern: '1' file: - access_level: open_access checksum: 123dd33e7f26761c82c74e10811a1e4d content_type: application/pdf creator: dernst date_created: 2020-01-22T15:58:54Z date_updated: 2020-07-14T12:47:55Z file_id: '7355' file_name: 2019_NatureComm_Kwak.pdf file_size: 1003676 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 10' language: - iso: eng month: '03' oa: 1 oa_version: Published Version publication: Nature Communications publication_identifier: issn: - 2041-1723 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 10 year: '2019' ... --- _id: '7276' abstract: - lang: eng text: Singlet oxygen (1O2) causes a major fraction of the parasitic chemistry during the cycling of non‐aqueous alkali metal‐O2 batteries and also contributes to interfacial reactivity of transition‐metal oxide intercalation compounds. We introduce DABCOnium, the mono alkylated form of 1,4‐diazabicyclo[2.2.2]octane (DABCO), as an efficient 1O2 quencher with an unusually high oxidative stability of ca. 4.2 V vs. Li/Li+. Previous quenchers are strongly Lewis basic amines with too low oxidative stability. DABCOnium is an ionic liquid, non‐volatile, highly soluble in the electrolyte, stable against superoxide and peroxide, and compatible with lithium metal. The electrochemical stability covers the required range for metal–O2 batteries and greatly reduces 1O2 related parasitic chemistry as demonstrated for the Li–O2 cell. article_processing_charge: No article_type: original author: - first_name: Yann K. full_name: Petit, Yann K. last_name: Petit - first_name: Christian full_name: Leypold, Christian last_name: Leypold - first_name: Nika full_name: Mahne, Nika last_name: Mahne - first_name: Eléonore full_name: Mourad, Eléonore last_name: Mourad - first_name: Lukas full_name: Schafzahl, Lukas last_name: Schafzahl - first_name: Christian full_name: Slugovc, Christian last_name: Slugovc - first_name: Sergey M. full_name: Borisov, Sergey M. last_name: Borisov - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 citation: ama: 'Petit YK, Leypold C, Mahne N, et al. DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. 2019;58(20):6535-6539. doi:10.1002/anie.201901869' apa: 'Petit, Y. K., Leypold, C., Mahne, N., Mourad, E., Schafzahl, L., Slugovc, C., … Freunberger, S. A. (2019). DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. Wiley. https://doi.org/10.1002/anie.201901869' chicago: 'Petit, Yann K., Christian Leypold, Nika Mahne, Eléonore Mourad, Lukas Schafzahl, Christian Slugovc, Sergey M. Borisov, and Stefan Alexander Freunberger. “DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2 Cells.” Angewandte Chemie International Edition. Wiley, 2019. https://doi.org/10.1002/anie.201901869.' ieee: 'Y. K. Petit et al., “DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells,” Angewandte Chemie International Edition, vol. 58, no. 20. Wiley, pp. 6535–6539, 2019.' ista: 'Petit YK, Leypold C, Mahne N, Mourad E, Schafzahl L, Slugovc C, Borisov SM, Freunberger SA. 2019. DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells. Angewandte Chemie International Edition. 58(20), 6535–6539.' mla: 'Petit, Yann K., et al. “DABCOnium: An Efficient and High-Voltage Stable Singlet Oxygen Quencher for Metal-O2 Cells.” Angewandte Chemie International Edition, vol. 58, no. 20, Wiley, 2019, pp. 6535–39, doi:10.1002/anie.201901869.' short: Y.K. Petit, C. Leypold, N. Mahne, E. Mourad, L. Schafzahl, C. Slugovc, S.M. Borisov, S.A. Freunberger, Angewandte Chemie International Edition 58 (2019) 6535–6539. date_created: 2020-01-15T07:19:27Z date_published: 2019-05-13T00:00:00Z date_updated: 2021-01-12T08:12:42Z day: '13' ddc: - '540' doi: 10.1002/anie.201901869 extern: '1' file: - access_level: open_access checksum: 9620b6a511a910d7abe1f26c42dc7f83 content_type: application/pdf creator: dernst date_created: 2020-01-22T16:16:54Z date_updated: 2020-07-14T12:47:55Z file_id: '7356' file_name: 2019_AngewChemie_Petit.pdf file_size: 952737 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 58' issue: '20' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: 6535-6539 publication: Angewandte Chemie International Edition publication_identifier: issn: - 1433-7851 publication_status: published publisher: Wiley quality_controlled: '1' status: public title: 'DABCOnium: An efficient and high-voltage stable singlet oxygen quencher for metal-O2 cells' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 58 year: '2019' ... --- _id: '7281' abstract: - lang: eng text: Li–O2 batteries are plagued by side reactions that cause poor rechargeability and efficiency. These reactions were recently revealed to be predominantly caused by singlet oxygen, which can be neutralized by chemical traps or physical quenchers. However, traps are irreversibly consumed and thus only active for a limited time, and so far identified quenchers lack oxidative stability to be suitable for typically required recharge potentials. Thus, reducing the charge potential within the stability limit of the quencher and/or finding more stable quenchers is required. Here, we show that dimethylphenazine as a redox mediator decreases the charge potential well within the stability limit of the quencher 1,4-diazabicyclo[2.2.2]octane. The quencher can thus mitigate the parasitic reactions without being oxidatively decomposed. At the same time the quencher protects the redox mediator from singlet oxygen attack. The mutual conservation of the redox mediator and the quencher is rational for stable and effective Li–O2 batteries. article_processing_charge: No article_type: original author: - first_name: Won-Jin full_name: Kwak, Won-Jin last_name: Kwak - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 - first_name: Hun full_name: Kim, Hun last_name: Kim - first_name: Jiwon full_name: Park, Jiwon last_name: Park - first_name: Trung Thien full_name: Nguyen, Trung Thien last_name: Nguyen - first_name: Hun-Gi full_name: Jung, Hun-Gi last_name: Jung - first_name: Hye Ryung full_name: Byon, Hye Ryung last_name: Byon - first_name: Yang-Kook full_name: Sun, Yang-Kook last_name: Sun citation: ama: Kwak W-J, Freunberger SA, Kim H, et al. Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries. ACS Catalysis. 2019;9(11):9914-9922. doi:10.1021/acscatal.9b01337 apa: Kwak, W.-J., Freunberger, S. A., Kim, H., Park, J., Nguyen, T. T., Jung, H.-G., … Sun, Y.-K. (2019). Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries. ACS Catalysis. ACS. https://doi.org/10.1021/acscatal.9b01337 chicago: Kwak, Won-Jin, Stefan Alexander Freunberger, Hun Kim, Jiwon Park, Trung Thien Nguyen, Hun-Gi Jung, Hye Ryung Byon, and Yang-Kook Sun. “Mutual Conservation of Redox Mediator and Singlet Oxygen Quencher in Lithium–Oxygen Batteries.” ACS Catalysis. ACS, 2019. https://doi.org/10.1021/acscatal.9b01337. ieee: W.-J. Kwak et al., “Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries,” ACS Catalysis, vol. 9, no. 11. ACS, pp. 9914–9922, 2019. ista: Kwak W-J, Freunberger SA, Kim H, Park J, Nguyen TT, Jung H-G, Byon HR, Sun Y-K. 2019. Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries. ACS Catalysis. 9(11), 9914–9922. mla: Kwak, Won-Jin, et al. “Mutual Conservation of Redox Mediator and Singlet Oxygen Quencher in Lithium–Oxygen Batteries.” ACS Catalysis, vol. 9, no. 11, ACS, 2019, pp. 9914–22, doi:10.1021/acscatal.9b01337. short: W.-J. Kwak, S.A. Freunberger, H. Kim, J. Park, T.T. Nguyen, H.-G. Jung, H.R. Byon, Y.-K. Sun, ACS Catalysis 9 (2019) 9914–9922. date_created: 2020-01-15T12:12:40Z date_published: 2019-11-01T00:00:00Z date_updated: 2021-01-12T08:12:44Z day: '01' ddc: - '540' doi: 10.1021/acscatal.9b01337 extern: '1' file: - access_level: open_access checksum: bbaebfe5ff0bcab6235821ba3460b7de content_type: application/pdf creator: sfreunbe date_created: 2020-06-29T15:19:30Z date_updated: 2020-07-14T12:47:55Z file_id: '8053' file_name: Revised Manuscript.pdf file_size: 1199086 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 9' issue: '11' language: - iso: eng month: '11' oa: 1 oa_version: Submitted Version page: 9914-9922 publication: ACS Catalysis publication_identifier: issn: - 2155-5435 publication_status: published publisher: ACS quality_controlled: '1' status: public title: Mutual conservation of redox mediator and singlet oxygen quencher in Lithium–Oxygen batteries type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 9 year: '2019' ... --- _id: '7282' abstract: - lang: eng text: Interphases that form on the anode surface of lithium-ion batteries are critical for performance and lifetime, but are poorly understood. Now, a decade-old misconception regarding a main component of the interphase has been revealed, which could potentially lead to improved devices. article_processing_charge: No article_type: letter_note author: - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 citation: ama: Freunberger SA. Interphase identity crisis. Nature Chemistry. 2019;11(9):761-763. doi:10.1038/s41557-019-0311-0 apa: Freunberger, S. A. (2019). Interphase identity crisis. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-019-0311-0 chicago: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature Chemistry. Springer Nature, 2019. https://doi.org/10.1038/s41557-019-0311-0. ieee: S. A. Freunberger, “Interphase identity crisis,” Nature Chemistry, vol. 11, no. 9. Springer Nature, pp. 761–763, 2019. ista: Freunberger SA. 2019. Interphase identity crisis. Nature Chemistry. 11(9), 761–763. mla: Freunberger, Stefan Alexander. “Interphase Identity Crisis.” Nature Chemistry, vol. 11, no. 9, Springer Nature, 2019, pp. 761–63, doi:10.1038/s41557-019-0311-0. short: S.A. Freunberger, Nature Chemistry 11 (2019) 761–763. date_created: 2020-01-15T12:12:53Z date_published: 2019-08-19T00:00:00Z date_updated: 2021-01-12T08:12:44Z day: '19' ddc: - '540' - '547' doi: 10.1038/s41557-019-0311-0 extern: '1' file: - access_level: open_access checksum: 76806cff3d5b62f846499a8617cee7ef content_type: application/pdf creator: sfreunbe date_created: 2020-06-29T15:38:21Z date_updated: 2020-07-14T12:47:55Z file_id: '8054' file_name: Freunberger on Eichhorn.pdf file_size: 286805 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 11' issue: '9' language: - iso: eng month: '08' oa: 1 oa_version: Submitted Version page: 761-763 publication: Nature Chemistry publication_identifier: issn: - 1755-4330 - 1755-4349 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Interphase identity crisis type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 11 year: '2019' ... --- _id: '7283' abstract: - lang: eng text: Potassium–air batteries, which suffer from oxygen cathode and potassium metal anode degradation, can be cycled thousands of times when an organic anode replaces the metal. article_processing_charge: No article_type: letter_note author: - first_name: Yann K. full_name: Petit, Yann K. last_name: Petit - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 citation: ama: Petit YK, Freunberger SA. Thousands of cycles. Nature Materials. 2019;18(4):301-302. doi:10.1038/s41563-019-0313-8 apa: Petit, Y. K., & Freunberger, S. A. (2019). Thousands of cycles. Nature Materials. Springer Nature. https://doi.org/10.1038/s41563-019-0313-8 chicago: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.” Nature Materials. Springer Nature, 2019. https://doi.org/10.1038/s41563-019-0313-8. ieee: Y. K. Petit and S. A. Freunberger, “Thousands of cycles,” Nature Materials, vol. 18, no. 4. Springer Nature, pp. 301–302, 2019. ista: Petit YK, Freunberger SA. 2019. Thousands of cycles. Nature Materials. 18(4), 301–302. mla: Petit, Yann K., and Stefan Alexander Freunberger. “Thousands of Cycles.” Nature Materials, vol. 18, no. 4, Springer Nature, 2019, pp. 301–02, doi:10.1038/s41563-019-0313-8. short: Y.K. Petit, S.A. Freunberger, Nature Materials 18 (2019) 301–302. date_created: 2020-01-15T12:13:05Z date_published: 2019-03-20T00:00:00Z date_updated: 2021-01-12T08:12:45Z day: '20' ddc: - '540' - '541' doi: 10.1038/s41563-019-0313-8 extern: '1' file: - access_level: open_access checksum: 4c9a0314327028a22dd902bc109b8798 content_type: application/pdf creator: sfreunbe date_created: 2020-06-29T16:26:54Z date_updated: 2020-07-14T12:47:55Z file_id: '8059' file_name: NaV_final.pdf file_size: 398123 relation: main_file file_date_updated: 2020-07-14T12:47:55Z has_accepted_license: '1' intvolume: ' 18' issue: '4' language: - iso: eng month: '03' oa: 1 oa_version: Submitted Version page: 301-302 publication: Nature Materials publication_identifier: issn: - 1476-1122 - 1476-4660 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Thousands of cycles type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 18 year: '2019' ...