---
_id: '8254'
abstract:
- lang: eng
text: "Here are the research data underlying the publication \"Estimating inbreeding
and its effects in a long-term study of snapdragons (Antirrhinum majus)\". Further
information are summed up in the README document.\r\nThe files for this record
have been updated and are now found in the linked DOI https://doi.org/10.15479/AT:ISTA:9192."
article_processing_charge: No
author:
- first_name: Louise S
full_name: Arathoon, Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
orcid: 0000-0003-1771-714X
citation:
ama: Arathoon LS. Estimating inbreeding and its effects in a long-term study of
snapdragons (Antirrhinum majus). 2020. doi:10.15479/AT:ISTA:8254
apa: Arathoon, L. S. (2020). Estimating inbreeding and its effects in a long-term
study of snapdragons (Antirrhinum majus). Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8254
chicago: Arathoon, Louise S. “Estimating Inbreeding and Its Effects in a Long-Term
Study of Snapdragons (Antirrhinum Majus).” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8254.
ieee: L. S. Arathoon, “Estimating inbreeding and its effects in a long-term study
of snapdragons (Antirrhinum majus).” Institute of Science and Technology Austria,
2020.
ista: Arathoon LS. 2020. Estimating inbreeding and its effects in a long-term study
of snapdragons (Antirrhinum majus), Institute of Science and Technology Austria,
10.15479/AT:ISTA:8254.
mla: Arathoon, Louise S. Estimating Inbreeding and Its Effects in a Long-Term
Study of Snapdragons (Antirrhinum Majus). Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:8254.
short: L.S. Arathoon, (2020).
contributor:
- contributor_type: data_collector
first_name: Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
- contributor_type: project_member
first_name: Parvathy
id: 455235B8-F248-11E8-B48F-1D18A9856A87
last_name: Surendranadh
- contributor_type: project_member
first_name: Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- contributor_type: project_member
first_name: David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- contributor_type: project_member
first_name: Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- contributor_type: project_member
first_name: Carina
id: 3B4A7CE2-F248-11E8-B48F-1D18A9856A87
last_name: Baskett
date_created: 2020-08-12T12:49:23Z
date_published: 2020-08-18T00:00:00Z
date_updated: 2024-02-21T12:41:09Z
day: '18'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:8254
file:
- access_level: open_access
checksum: 4f1382ed4384751b6013398c11557bf6
content_type: application/x-zip-compressed
creator: dernst
date_created: 2020-08-18T08:03:23Z
date_updated: 2020-08-18T08:03:23Z
file_id: '8280'
file_name: Data_Rcode_MathematicaNB.zip
file_size: 5778420
relation: main_file
success: 1
file_date_updated: 2020-08-18T08:03:23Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11321'
relation: later_version
status: public
- id: '9192'
relation: later_version
status: public
status: public
title: Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum
majus)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7541'
abstract:
- lang: eng
text: Semiconductor nanowires have been playing a crucial role in the development
of nanoscale devices for the realization of spin qubits, Majorana fermions, single
photon emitters, nanoprocessors, etc. The monolithic growth of site‐controlled
nanowires is a prerequisite toward the next generation of devices that will require
addressability and scalability. Here, combining top‐down nanofabrication and bottom‐up
self‐assembly, the growth of Ge wires on prepatterned Si (001) substrates with
controllable position, distance, length, and structure is reported. This is achieved
by a novel growth process that uses a SiGe strain‐relaxation template and can
be potentially generalized to other material combinations. Transport measurements
show an electrically tunable spin–orbit coupling, with a spin–orbit length similar
to that of III–V materials. Also, charge sensing between quantum dots in closely
spaced wires is observed, which underlines their potential for the realization
of advanced quantum devices. The reported results open a path toward scalable
qubit devices using nanowires on silicon.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: 'This work was supported by the National Key R&D Program of China
(Grant Nos. 2016YFA0301701 and 2016YFA0300600), the NSFC (Grant Nos. 11574356, 11434010,
and 11404252), the Strategic Priority Research Program of CAS (Grant No. XDB30000000),
the ERC Starting Grant No. 335497, the FWF P32235 project, and the European Union''s
Horizon 2020 research and innovation program under Grant Agreement #862046. This
research was supported by the Scientific Service Units of IST Austria through resources
provided by the MIBA Machine Shop and the nanofabrication facility. F.L. thanks
support from DOE (Grant No. DE‐FG02‐04ER46148). H.H. thanks the Startup Funding
from Xi''an Jiaotong University.'
article_number: '1906523'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fei
full_name: Gao, Fei
last_name: Gao
- first_name: Jian-Huan
full_name: Wang, Jian-Huan
last_name: Wang
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
- first_name: Hao
full_name: Hu, Hao
last_name: Hu
- first_name: Marko J.
full_name: Rančić, Marko J.
last_name: Rančić
- first_name: Jie-Yin
full_name: Zhang, Jie-Yin
last_name: Zhang
- first_name: Ting
full_name: Wang, Ting
last_name: Wang
- first_name: Yuan
full_name: Yao, Yuan
last_name: Yao
- first_name: Gui-Lei
full_name: Wang, Gui-Lei
last_name: Wang
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Lada
full_name: Vukušić, Lada
id: 31E9F056-F248-11E8-B48F-1D18A9856A87
last_name: Vukušić
orcid: 0000-0003-2424-8636
- first_name: Christoph
full_name: Kloeffel, Christoph
last_name: Kloeffel
- first_name: Daniel
full_name: Loss, Daniel
last_name: Loss
- first_name: Feng
full_name: Liu, Feng
last_name: Liu
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Jian-Jun
full_name: Zhang, Jian-Jun
last_name: Zhang
citation:
ama: Gao F, Wang J-H, Watzinger H, et al. Site-controlled uniform Ge/Si hut wires
with electrically tunable spin-orbit coupling. Advanced Materials. 2020;32(16).
doi:10.1002/adma.201906523
apa: Gao, F., Wang, J.-H., Watzinger, H., Hu, H., Rančić, M. J., Zhang, J.-Y., …
Zhang, J.-J. (2020). Site-controlled uniform Ge/Si hut wires with electrically
tunable spin-orbit coupling. Advanced Materials. Wiley. https://doi.org/10.1002/adma.201906523
chicago: Gao, Fei, Jian-Huan Wang, Hannes Watzinger, Hao Hu, Marko J. Rančić, Jie-Yin
Zhang, Ting Wang, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically
Tunable Spin-Orbit Coupling.” Advanced Materials. Wiley, 2020. https://doi.org/10.1002/adma.201906523.
ieee: F. Gao et al., “Site-controlled uniform Ge/Si hut wires with electrically
tunable spin-orbit coupling,” Advanced Materials, vol. 32, no. 16. Wiley,
2020.
ista: Gao F, Wang J-H, Watzinger H, Hu H, Rančić MJ, Zhang J-Y, Wang T, Yao Y, Wang
G-L, Kukucka J, Vukušić L, Kloeffel C, Loss D, Liu F, Katsaros G, Zhang J-J. 2020.
Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling.
Advanced Materials. 32(16), 1906523.
mla: Gao, Fei, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically
Tunable Spin-Orbit Coupling.” Advanced Materials, vol. 32, no. 16, 1906523,
Wiley, 2020, doi:10.1002/adma.201906523.
short: F. Gao, J.-H. Wang, H. Watzinger, H. Hu, M.J. Rančić, J.-Y. Zhang, T. Wang,
Y. Yao, G.-L. Wang, J. Kukucka, L. Vukušić, C. Kloeffel, D. Loss, F. Liu, G. Katsaros,
J.-J. Zhang, Advanced Materials 32 (2020).
date_created: 2020-02-28T09:47:00Z
date_published: 2020-04-23T00:00:00Z
date_updated: 2024-02-21T12:42:12Z
day: '23'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.1002/adma.201906523
ec_funded: 1
external_id:
isi:
- '000516660900001'
file:
- access_level: open_access
checksum: c622737dc295972065782558337124a2
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T10:11:35Z
date_updated: 2020-11-20T10:11:35Z
file_id: '8782'
file_name: 2020_AdvancedMaterials_Gao.pdf
file_size: 5242880
relation: main_file
success: 1
file_date_updated: 2020-11-20T10:11:35Z
has_accepted_license: '1'
intvolume: ' 32'
isi: 1
issue: '16'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 25517E86-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '335497'
name: Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires
- _id: 237B3DA4-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: P32235
name: Towards scalable hut wire quantum devices
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
publication: Advanced Materials
publication_identifier:
issn:
- 0935-9648
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '7996'
relation: dissertation_contains
status: public
- id: '9222'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit
coupling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2020'
...
---
_id: '8930'
abstract:
- lang: eng
text: Phenomenological relations such as Ohm’s or Fourier’s law have a venerable
history in physics but are still scarce in biology. This situation restrains predictive
theory. Here, we build on bacterial “growth laws,” which capture physiological
feedback between translation and cell growth, to construct a minimal biophysical
model for the combined action of ribosome-targeting antibiotics. Our model predicts
drug interactions like antagonism or synergy solely from responses to individual
drugs. We provide analytical results for limiting cases, which agree well with
numerical results. We systematically refine the model by including direct physical
interactions of different antibiotics on the ribosome. In a limiting case, our
model provides a mechanistic underpinning for recent predictions of higher-order
interactions that were derived using entropy maximization. We further refine the
model to include the effects of antibiotics that mimic starvation and the presence
of resistance genes. We describe the impact of a starvation-mimicking antibiotic
on drug interactions analytically and verify it experimentally. Our extended model
suggests a change in the type of drug interaction that depends on the strength
of resistance, which challenges established rescaling paradigms. We experimentally
show that the presence of unregulated resistance genes can lead to altered drug
interaction, which agrees with the prediction of the model. While minimal, the
model is readily adaptable and opens the door to predicting interactions of second
and higher-order in a broad range of biological systems.
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
citation:
ama: Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical
model of combined antibiotic action.” 2020. doi:10.15479/AT:ISTA:8930
apa: Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal
biophysical model of combined antibiotic action.” Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8930
chicago: Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal
Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8930.
ieee: B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical
model of combined antibiotic action.’” Institute of Science and Technology Austria,
2020.
ista: Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal
biophysical model of combined antibiotic action’, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:8930.
mla: Kavcic, Bor. Analysis Scripts and Research Data for the Paper “Minimal Biophysical
Model of Combined Antibiotic Action.” Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:8930.
short: B. Kavcic, (2020).
contributor:
- contributor_type: supervisor
first_name: Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- contributor_type: supervisor
first_name: Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
date_created: 2020-12-09T15:04:02Z
date_published: 2020-12-10T00:00:00Z
date_updated: 2024-02-21T12:41:42Z
day: '10'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.15479/AT:ISTA:8930
file:
- access_level: open_access
checksum: 60a818edeffaa7da1ebf5f8fbea9ba18
content_type: application/zip
creator: bkavcic
date_created: 2020-12-09T15:00:19Z
date_updated: 2020-12-09T15:00:19Z
file_id: '8932'
file_name: PLoSCompBiol2020_datarep.zip
file_size: 315494370
relation: main_file
success: 1
file_date_updated: 2020-12-09T15:00:19Z
has_accepted_license: '1'
keyword:
- Escherichia coli
- antibiotic combinations
- translation
- growth laws
- drug interactions
- bacterial physiology
- translation inhibitors
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8997'
relation: used_in_publication
status: public
status: public
title: Analysis scripts and research data for the paper "Minimal biophysical model
of combined antibiotic action"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8951'
abstract:
- lang: eng
text: Gene expression levels are influenced by multiple coexisting molecular mechanisms.
Some of these interactions, such as those of transcription factors and promoters
have been studied extensively. However, predicting phenotypes of gene regulatory
networks remains a major challenge. Here, we use a well-defined synthetic gene
regulatory network to study how network phenotypes depend on local genetic context,
i.e. the genetic neighborhood of a transcription factor and its relative position.
We show that one gene regulatory network with fixed topology can display not only
quantitatively but also qualitatively different phenotypes, depending solely on
the local genetic context of its components. Our results demonstrate that changes
in local genetic context can place a single transcriptional unit within two separate
regulons without the need for complex regulatory sequences. We propose that relative
order of individual transcriptional units, with its potential for combinatorial
complexity, plays an important role in shaping phenotypes of gene regulatory networks.
article_processing_charge: No
author:
- first_name: Anna A
full_name: Nagy-Staron, Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
orcid: 0000-0002-1391-8377
citation:
ama: Nagy-Staron AA. Sequences of gene regulatory network permutations for the article
“Local genetic context shapes the function of a gene regulatory network.” 2020.
doi:10.15479/AT:ISTA:8951
apa: Nagy-Staron, A. A. (2020). Sequences of gene regulatory network permutations
for the article “Local genetic context shapes the function of a gene regulatory
network.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8951
chicago: Nagy-Staron, Anna A. “Sequences of Gene Regulatory Network Permutations
for the Article ‘Local Genetic Context Shapes the Function of a Gene Regulatory
Network.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8951.
ieee: A. A. Nagy-Staron, “Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network.’”
Institute of Science and Technology Austria, 2020.
ista: Nagy-Staron AA. 2020. Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network’,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:8951.
mla: Nagy-Staron, Anna A. Sequences of Gene Regulatory Network Permutations for
the Article “Local Genetic Context Shapes the Function of a Gene Regulatory Network.”
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8951.
short: A.A. Nagy-Staron, (2020).
contributor:
- contributor_type: project_member
first_name: Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
- contributor_type: project_member
first_name: Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
- contributor_type: project_member
first_name: Caroline
last_name: Caruso Carter
- contributor_type: project_member
first_name: Elisabeth
last_name: Sonnleitner
- contributor_type: project_member
first_name: Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- contributor_type: project_member
first_name: Tiago
last_name: Paixão
- contributor_type: project_manager
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
date_created: 2020-12-20T10:00:26Z
date_published: 2020-12-21T00:00:00Z
date_updated: 2024-02-21T12:41:57Z
day: '21'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8951
file:
- access_level: open_access
checksum: f57862aeee1690c7effd2b1117d40ed1
content_type: text/plain
creator: bkavcic
date_created: 2020-12-20T09:52:52Z
date_updated: 2020-12-20T09:52:52Z
file_id: '8952'
file_name: readme.txt
file_size: 523
relation: main_file
success: 1
- access_level: open_access
checksum: f2c6d5232ec6d551b6993991e8689e9f
content_type: application/octet-stream
creator: bkavcic
date_created: 2020-12-20T22:01:44Z
date_updated: 2020-12-20T22:01:44Z
file_id: '8954'
file_name: GRNs Research depository.gb
file_size: 379228
relation: main_file
success: 1
file_date_updated: 2020-12-20T22:01:44Z
has_accepted_license: '1'
keyword:
- Gene regulatory networks
- Gene expression
- Escherichia coli
- Synthetic Biology
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9283'
relation: used_in_publication
status: public
status: public
title: Sequences of gene regulatory network permutations for the article "Local genetic
context shapes the function of a gene regulatory network"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7383'
abstract:
- lang: eng
text: Organisms cope with change by employing transcriptional regulators. However,
when faced with rare environments, the evolution of transcriptional regulators
and their promoters may be too slow. We ask whether the intrinsic instability
of gene duplication and amplification provides a generic alternative to canonical
gene regulation. By real-time monitoring of gene copy number mutations in E. coli,
we show that gene duplications and amplifications enable adaptation to fluctuating
environments by rapidly generating copy number, and hence expression level, polymorphism.
This ‘amplification-mediated gene expression tuning’ occurs on timescales similar
to canonical gene regulation and can deal with rapid environmental changes. Mathematical
modeling shows that amplifications also tune gene expression in stochastic environments
where transcription factor-based schemes are hard to evolve or maintain. The fleeting
nature of gene amplifications gives rise to a generic population-level mechanism
that relies on genetic heterogeneity to rapidly tune expression of any gene, without
leaving any genomic signature.
article_processing_charge: No
author:
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
citation:
ama: 'Grah R. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation. 2020. doi:10.15479/AT:ISTA:7383'
apa: 'Grah, R. (2020). Matlab scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression regulation. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:7383'
chicago: 'Grah, Rok. “Matlab Scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression Regulation.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:7383.'
ieee: 'R. Grah, “Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation.” Institute of Science and Technology Austria, 2020.'
ista: 'Grah R. 2020. Matlab scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression regulation, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:7383.'
mla: 'Grah, Rok. Matlab Scripts for the Paper: Gene Amplification as a Form of
Population-Level Gene Expression Regulation. Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:7383.'
short: R. Grah, (2020).
contributor:
- contributor_type: project_leader
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
date_created: 2020-01-28T10:41:49Z
date_published: 2020-01-28T00:00:00Z
date_updated: 2024-02-21T12:42:31Z
day: '28'
department:
- _id: CaGu
- _id: GaTk
doi: 10.15479/AT:ISTA:7383
file:
- access_level: open_access
checksum: 9d292cf5207b3829225f44c044cdb3fd
content_type: application/zip
creator: rgrah
date_created: 2020-01-28T10:39:40Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7384'
file_name: Scripts.zip
file_size: 73363365
relation: main_file
- access_level: open_access
checksum: 4076ceab32ef588cc233802bab24c1ab
content_type: text/plain
creator: rgrah
date_created: 2020-01-28T10:39:30Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7385'
file_name: READ_ME_MAIN.txt
file_size: 962
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
keyword:
- Matlab scripts
- analysis of microfluidics
- mathematical model
month: '01'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7652'
relation: used_in_publication
status: public
status: public
title: 'Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation'
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '9222'
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: 'Katsaros G. Transport data for: Site‐controlled uniform Ge/Si Hut wires with
electrically tunable spin–orbit coupling. 2020. doi:10.15479/AT:ISTA:9222'
apa: 'Katsaros, G. (2020). Transport data for: Site‐controlled uniform Ge/Si Hut
wires with electrically tunable spin–orbit coupling. Institute of Science and
Technology Austria. https://doi.org/10.15479/AT:ISTA:9222'
chicago: 'Katsaros, Georgios. “Transport Data for: Site‐controlled Uniform Ge/Si
Hut Wires with Electrically Tunable Spin–Orbit Coupling.” Institute of Science
and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:9222.'
ieee: 'G. Katsaros, “Transport data for: Site‐controlled uniform Ge/Si Hut wires
with electrically tunable spin–orbit coupling.” Institute of Science and Technology
Austria, 2020.'
ista: 'Katsaros G. 2020. Transport data for: Site‐controlled uniform Ge/Si Hut wires
with electrically tunable spin–orbit coupling, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:9222.'
mla: 'Katsaros, Georgios. Transport Data for: Site‐controlled Uniform Ge/Si Hut
Wires with Electrically Tunable Spin–Orbit Coupling. Institute of Science
and Technology Austria, 2020, doi:10.15479/AT:ISTA:9222.'
short: G. Katsaros, (2020).
contributor:
- contributor_type: research_group
first_name: Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
date_created: 2021-03-05T18:00:47Z
date_published: 2020-03-16T00:00:00Z
date_updated: 2024-02-21T12:42:13Z
day: '16'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:9222
file:
- access_level: open_access
checksum: 41b66e195ed3dbd73077feee77b05652
content_type: application/x-zip-compressed
creator: gkatsaro
date_created: 2021-03-05T17:50:45Z
date_updated: 2021-03-05T17:50:45Z
file_id: '9223'
file_name: DOI_SiteControlledHWs.zip
file_size: 13317557
relation: main_file
- access_level: open_access
checksum: a1dc5f710ba4b3bb7f248195ba754ab2
content_type: text/plain
creator: dernst
date_created: 2021-03-10T07:31:50Z
date_updated: 2021-03-10T07:31:50Z
file_id: '9233'
file_name: Readme.txt
file_size: 3515
relation: main_file
success: 1
file_date_updated: 2021-03-10T07:31:50Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7541'
relation: used_in_publication
status: public
status: public
title: 'Transport data for: Site‐controlled uniform Ge/Si Hut wires with electrically
tunable spin–orbit coupling'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8366'
abstract:
- lang: eng
text: "Fabrication of curved shells plays an important role in modern design, industry,
and science. Among their remarkable properties are, for example, aesthetics of
organic shapes, ability to evenly distribute loads, or efficient flow separation.
They find applications across vast length scales ranging from sky-scraper architecture
to microscopic devices. But, at\r\nthe same time, the design of curved shells
and their manufacturing process pose a variety of challenges. In this thesis,
they are addressed from several perspectives. In particular, this thesis presents
approaches based on the transformation of initially flat sheets into the target
curved surfaces. This involves problems of interactive design of shells with nontrivial
mechanical constraints, inverse design of complex structural materials, and data-driven
modeling of delicate and time-dependent physical properties. At the same time,
two newly-developed self-morphing mechanisms targeting flat-to-curved transformation
are presented.\r\nIn architecture, doubly curved surfaces can be realized as cold
bent glass panelizations. Originally flat glass panels are bent into frames and
remain stressed. This is a cost-efficient fabrication approach compared to hot
bending, when glass panels are shaped plastically. However such constructions
are prone to breaking during bending, and it is highly\r\nnontrivial to navigate
the design space, keeping the panels fabricable and aesthetically pleasing at
the same time. We introduce an interactive design system for cold bent glass façades,
while previously even offline optimization for such scenarios has not been sufficiently
developed. Our method is based on a deep learning approach providing quick\r\nand
high precision estimation of glass panel shape and stress while handling the shape\r\nmultimodality.\r\nFabrication
of smaller objects of scales below 1 m, can also greatly benefit from shaping
originally flat sheets. In this respect, we designed new self-morphing shell mechanisms
transforming from an initial flat state to a doubly curved state with high precision
and detail. Our so-called CurveUps demonstrate the encodement of the geometric
information\r\ninto the shell. Furthermore, we explored the frontiers of programmable
materials and showed how temporal information can additionally be encoded into
a flat shell. This allows prescribing deformation sequences for doubly curved
surfaces and, thus, facilitates self-collision avoidance enabling complex shapes
and functionalities otherwise impossible.\r\nBoth of these methods include inverse
design tools keeping the user in the design loop."
acknowledged_ssus:
- _id: M-Shop
- _id: ScienComp
acknowledgement: "During the work on this thesis, I received substantial support from
IST Austria’s scientific service units. A big thank you to Todor Asenov and other
Miba Machine Shop team members for their help with fabrication of experimental prototypes.
In addition, I would like to thank Scientific Computing team for the support with
high performance computing.\r\nFinancial support was provided by the European Research
Council (ERC) under grant agreement No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented
Computational Design and Modeling, which I gratefully acknowledge."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: 'Guseinov R. Computational design of curved thin shells: From glass façades
to programmable matter. 2020. doi:10.15479/AT:ISTA:8366'
apa: 'Guseinov, R. (2020). Computational design of curved thin shells: From glass
façades to programmable matter. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:8366'
chicago: 'Guseinov, Ruslan. “Computational Design of Curved Thin Shells: From Glass
Façades to Programmable Matter.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:8366.'
ieee: 'R. Guseinov, “Computational design of curved thin shells: From glass façades
to programmable matter,” Institute of Science and Technology Austria, 2020.'
ista: 'Guseinov R. 2020. Computational design of curved thin shells: From glass
façades to programmable matter. Institute of Science and Technology Austria.'
mla: 'Guseinov, Ruslan. Computational Design of Curved Thin Shells: From Glass
Façades to Programmable Matter. Institute of Science and Technology Austria,
2020, doi:10.15479/AT:ISTA:8366.'
short: 'R. Guseinov, Computational Design of Curved Thin Shells: From Glass Façades
to Programmable Matter, Institute of Science and Technology Austria, 2020.'
date_created: 2020-09-10T16:19:55Z
date_published: 2020-09-21T00:00:00Z
date_updated: 2024-02-21T12:44:29Z
day: '21'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8366
ec_funded: 1
file:
- access_level: open_access
checksum: f8da89553da36037296b0a80f14ebf50
content_type: application/pdf
creator: rguseino
date_created: 2020-09-10T16:11:49Z
date_updated: 2020-09-10T16:11:49Z
file_id: '8367'
file_name: thesis_rguseinov.pdf
file_size: 70950442
relation: main_file
success: 1
- access_level: closed
checksum: e8fd944c960c20e0e27e6548af69121d
content_type: application/x-zip-compressed
creator: rguseino
date_created: 2020-09-11T09:39:48Z
date_updated: 2020-09-16T15:11:01Z
file_id: '8374'
file_name: thesis_source.zip
file_size: 76207597
relation: source_file
file_date_updated: 2020-09-16T15:11:01Z
has_accepted_license: '1'
keyword:
- computer-aided design
- shape modeling
- self-morphing
- mechanical engineering
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '118'
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication_identifier:
isbn:
- 978-3-99078-010-7
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7151'
relation: research_data
status: deleted
- id: '7262'
relation: part_of_dissertation
status: public
- id: '8562'
relation: part_of_dissertation
status: public
- id: '1001'
relation: part_of_dissertation
status: public
- id: '8375'
relation: research_data
status: public
status: public
supervisor:
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
title: 'Computational design of curved thin shells: From glass façades to programmable
matter'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8562'
abstract:
- lang: eng
text: "Cold bent glass is a promising and cost-efficient method for realizing doubly
curved glass facades. They are produced by attaching planar glass sheets to curved
frames and require keeping the occurring stress within safe limits.\r\nHowever,
it is very challenging to navigate the design space of cold bent glass panels
due to the fragility of the material, which impedes the form-finding for practically
feasible and aesthetically pleasing cold bent glass facades. We propose an interactive,
data-driven approach for designing cold bent glass facades that can be seamlessly
integrated into a typical architectural design pipeline. Our method allows non-expert
users to interactively edit a parametric surface while providing real-time feedback
on the deformed shape and maximum stress of cold bent glass panels. Designs are
automatically refined to minimize several fairness criteria while maximal stresses
are kept within glass limits. We achieve interactive frame rates by using a differentiable
Mixture Density Network trained from more than a million simulations. Given a
curved boundary, our regression model is capable of handling multistable\r\nconfigurations
and accurately predicting the equilibrium shape of the panel and its corresponding
maximal stress. We show predictions are highly accurate and validate our results
with a physical realization of a cold bent glass surface."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank IST Austria’s Scientific Computing team for their support,
Corinna Datsiou and Sophie Pennetier for their expert input on the practical applications
of cold bent glass, and Zaha Hadid Architects and Waagner Biro for providing the
architectural datasets. Photo of Fondation Louis Vuitton by Francisco Anzola / CC
BY 2.0 / cropped.\r\nPhoto of Opus by Danica O. Kus. This project has received funding
from the European Union’s\r\nHorizon 2020 research and innovation program under
grant agreement No 675789 - Algebraic Representations in Computer-Aided Design for
complEx Shapes (ARCADES), from the European Research Council (ERC) under grant agreement
No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented Computational Design
and Modeling, and SFB-Transregio “Discretization in Geometry and Dynamics” through
grant I 2978 of the Austrian Science Fund (FWF). F. Rist and K. Gavriil have been
partially supported by KAUST baseline funding."
article_number: '208'
article_processing_charge: No
article_type: original
author:
- first_name: Konstantinos
full_name: Gavriil, Konstantinos
last_name: Gavriil
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- first_name: Jesus
full_name: Perez Rodriguez, Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- first_name: Davide
full_name: Pellis, Davide
last_name: Pellis
- first_name: Paul M
full_name: Henderson, Paul M
id: 13C09E74-18D9-11E9-8878-32CFE5697425
last_name: Henderson
orcid: 0000-0002-5198-7445
- first_name: Florian
full_name: Rist, Florian
last_name: Rist
- first_name: Helmut
full_name: Pottmann, Helmut
last_name: Pottmann
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: Gavriil K, Guseinov R, Perez Rodriguez J, et al. Computational design of cold
bent glass façades. ACM Transactions on Graphics. 2020;39(6). doi:10.1145/3414685.3417843
apa: Gavriil, K., Guseinov, R., Perez Rodriguez, J., Pellis, D., Henderson, P. M.,
Rist, F., … Bickel, B. (2020). Computational design of cold bent glass façades.
ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3414685.3417843
chicago: Gavriil, Konstantinos, Ruslan Guseinov, Jesus Perez Rodriguez, Davide Pellis,
Paul M Henderson, Florian Rist, Helmut Pottmann, and Bernd Bickel. “Computational
Design of Cold Bent Glass Façades.” ACM Transactions on Graphics. Association
for Computing Machinery, 2020. https://doi.org/10.1145/3414685.3417843.
ieee: K. Gavriil et al., “Computational design of cold bent glass façades,”
ACM Transactions on Graphics, vol. 39, no. 6. Association for Computing
Machinery, 2020.
ista: Gavriil K, Guseinov R, Perez Rodriguez J, Pellis D, Henderson PM, Rist F,
Pottmann H, Bickel B. 2020. Computational design of cold bent glass façades. ACM
Transactions on Graphics. 39(6), 208.
mla: Gavriil, Konstantinos, et al. “Computational Design of Cold Bent Glass Façades.”
ACM Transactions on Graphics, vol. 39, no. 6, 208, Association for Computing
Machinery, 2020, doi:10.1145/3414685.3417843.
short: K. Gavriil, R. Guseinov, J. Perez Rodriguez, D. Pellis, P.M. Henderson, F.
Rist, H. Pottmann, B. Bickel, ACM Transactions on Graphics 39 (2020).
date_created: 2020-09-23T11:30:02Z
date_published: 2020-11-26T00:00:00Z
date_updated: 2024-02-21T12:43:21Z
day: '26'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3414685.3417843
ec_funded: 1
external_id:
arxiv:
- '2009.03667'
isi:
- '000595589100048'
file:
- access_level: open_access
checksum: c7f67717ad74e670b7daeae732abe151
content_type: application/pdf
creator: bbickel
date_created: 2023-05-23T20:54:43Z
date_updated: 2023-05-23T20:54:43Z
file_id: '13084'
file_name: coldglass.pdf
file_size: 28964641
relation: main_file
success: 1
file_date_updated: 2023-05-23T20:54:43Z
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
issue: '6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/bend-dont-break/
record:
- id: '8366'
relation: dissertation_contains
status: public
- id: '8761'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Computational design of cold bent glass façades
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 39
year: '2020'
...
---
_id: '8203'
abstract:
- lang: eng
text: Using inelastic cotunneling spectroscopy we observe a zero field splitting
within the spin triplet manifold of Ge hut wire quantum dots. The states with
spin ±1 in the confinement direction are energetically favored by up to 55 μeV
compared to the spin 0 triplet state because of the strong spin–orbit coupling.
The reported effect should be observable in a broad class of strongly confined
hole quantum-dot systems and might need to be considered when operating hole spin
qubits.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: "We acknowledge G. Burkard, V. N. Golovach, C. Kloeffel, D.Loss,
P. Rabl, and M. Rancič ́ for helpful discussions. We\r\nfurther acknowledge T.
Adletzberger, J. Aguilera, T. Asenov, S. Bagiante, T. Menner, L. Shafeek, P. Taus,
P. Traunmüller, and D. Waldhausl for their invaluable assistance. This research
was supported by the Scientific Service Units of IST Austria through resources provided
by the MIBA Machine Shop and the nanofabrication facility, by the FWF-P 32235 project,
by the National Key R&D Program of China (2016YFA0301701, 2016YFA0300600), and by
the European Union’s Horizon 2020 research and innovation program under grant agreement
no. 862046. All data of this publication are available at 10.15479/AT:ISTA:7689."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Lada
full_name: Vukušić, Lada
id: 31E9F056-F248-11E8-B48F-1D18A9856A87
last_name: Vukušić
orcid: 0000-0003-2424-8636
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
- first_name: Fei
full_name: Gao, Fei
last_name: Gao
- first_name: Ting
full_name: Wang, Ting
last_name: Wang
orcid: 0000-0002-4619-9575
- first_name: Jian-Jun
full_name: Zhang, Jian-Jun
last_name: Zhang
- first_name: Karsten
full_name: Held, Karsten
last_name: Held
citation:
ama: Katsaros G, Kukucka J, Vukušić L, et al. Zero field splitting of heavy-hole
states in quantum dots. Nano Letters. 2020;20(7):5201-5206. doi:10.1021/acs.nanolett.0c01466
apa: Katsaros, G., Kukucka, J., Vukušić, L., Watzinger, H., Gao, F., Wang, T., …
Held, K. (2020). Zero field splitting of heavy-hole states in quantum dots. Nano
Letters. American Chemical Society. https://doi.org/10.1021/acs.nanolett.0c01466
chicago: Katsaros, Georgios, Josip Kukucka, Lada Vukušić, Hannes Watzinger, Fei
Gao, Ting Wang, Jian-Jun Zhang, and Karsten Held. “Zero Field Splitting of Heavy-Hole
States in Quantum Dots.” Nano Letters. American Chemical Society, 2020.
https://doi.org/10.1021/acs.nanolett.0c01466.
ieee: G. Katsaros et al., “Zero field splitting of heavy-hole states in quantum
dots,” Nano Letters, vol. 20, no. 7. American Chemical Society, pp. 5201–5206,
2020.
ista: Katsaros G, Kukucka J, Vukušić L, Watzinger H, Gao F, Wang T, Zhang J-J, Held
K. 2020. Zero field splitting of heavy-hole states in quantum dots. Nano Letters.
20(7), 5201–5206.
mla: Katsaros, Georgios, et al. “Zero Field Splitting of Heavy-Hole States in Quantum
Dots.” Nano Letters, vol. 20, no. 7, American Chemical Society, 2020, pp.
5201–06, doi:10.1021/acs.nanolett.0c01466.
short: G. Katsaros, J. Kukucka, L. Vukušić, H. Watzinger, F. Gao, T. Wang, J.-J.
Zhang, K. Held, Nano Letters 20 (2020) 5201–5206.
date_created: 2020-08-06T09:25:04Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2024-02-21T12:44:01Z
day: '01'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.1021/acs.nanolett.0c01466
ec_funded: 1
external_id:
isi:
- '000548893200066'
pmid:
- '32479090'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-08-06T09:35:37Z
date_updated: 2020-08-06T09:35:37Z
file_id: '8204'
file_name: 2020_NanoLetters_Katsaros.pdf
file_size: 3308906
relation: main_file
success: 1
file_date_updated: 2020-08-06T09:35:37Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
issue: '7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 5201-5206
pmid: 1
project:
- _id: 237B3DA4-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: P32235
name: Towards scalable hut wire quantum devices
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
publication: Nano Letters
publication_identifier:
eissn:
- 1530-6992
issn:
- 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
related_material:
record:
- id: '7689'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Zero field splitting of heavy-hole states in quantum dots
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 20
year: '2020'
...
---
_id: '8740'
abstract:
- lang: eng
text: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory
interneurons could undergo Hebbian, associative, or non-associative plasticity.
Both behavioral and learning-dependent reorganization of these connections has
also been demonstrated by measuring spike transmission probabilities in pyramidal
cell-interneuron spike cross-correlations that indicate monosynaptic connections.
Here we investigated the activity-dependent modification of these connections
during exploratory behavior in rats by optogenetically inhibiting pyramidal cell
and interneuron subpopulations. Light application and associated firing alteration
of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron
connection weights as indicated by spike transmission changes. Spike transmission
alterations were predicted by the light-mediated changes in the number of pre-
and postsynaptic spike pairing events and by firing rate changes of interneurons
but not pyramidal cells. This work demonstrates the presence of activity-dependent
associative and non-associative reorganization of pyramidal-interneuron connections
triggered by the optogenetic modification of the firing rate and spike synchrony
of cells.
acknowledgement: We thank Michele Nardin and Federico Stella for comments on an earlier
version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP
plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40
plasmid through Penn Vector Core. This work was supported by the Austrian Science
Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The
authors declare no conflicts of interest.
article_number: '61106'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 2020;9. doi:10.7554/eLife.61106
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.61106
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron
Connections during Behavior.” ELife. eLife Sciences Publications, 2020.
https://doi.org/10.7554/eLife.61106.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic
inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior,” eLife, vol. 9. eLife Sciences Publications,
2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 9, 61106.
mla: Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent
Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” ELife,
vol. 9, 61106, eLife Sciences Publications, 2020, doi:10.7554/eLife.61106.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).
date_created: 2020-11-08T23:01:25Z
date_published: 2020-10-05T00:00:00Z
date_updated: 2024-02-21T12:43:40Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.7554/eLife.61106
external_id:
isi:
- '000584369000001'
file:
- access_level: open_access
checksum: 6a7b0543c440f4c000a1864e69377d95
content_type: application/pdf
creator: dernst
date_created: 2020-11-09T09:17:40Z
date_updated: 2020-11-09T09:17:40Z
file_id: '8749'
file_name: 2020_eLife_Gridchyn.pdf
file_size: 447669
relation: main_file
success: 1
file_date_updated: 2020-11-09T09:17:40Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03713
name: Interneuro Plasticity During Spatial Learning
publication: eLife
publication_identifier:
eissn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '8563'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...