---
_id: '7389'
abstract:
- lang: eng
text: "Recently Kloeckner described the structure of the isometry group of the quadratic
Wasserstein space W_2(R^n). It turned out that the case of the real line is exceptional
in the sense that there exists an exotic isometry flow. Following this line of
investigation, we compute Isom(W_p(R)), the isometry group of the Wasserstein
space\r\nW_p(R) for all p \\in [1,\\infty) \\setminus {2}. We show that W_2(R)
is also exceptional regarding the\r\nparameter p: W_p(R) is isometrically rigid
if and only if p is not equal to 2. Regarding the underlying\r\nspace, we prove
that the exceptionality of p = 2 disappears if we replace R by the compact\r\ninterval
[0,1]. Surprisingly, in that case, W_p([0,1]) is isometrically rigid if and only
if\r\np is not equal to 1. Moreover, W_1([0,1]) admits isometries that split mass,
and Isom(W_1([0,1]))\r\ncannot be embedded into Isom(W_1(R))."
article_processing_charge: No
article_type: original
author:
- first_name: Gyorgy Pal
full_name: Geher, Gyorgy Pal
last_name: Geher
- first_name: Tamas
full_name: Titkos, Tamas
last_name: Titkos
- first_name: Daniel
full_name: Virosztek, Daniel
id: 48DB45DA-F248-11E8-B48F-1D18A9856A87
last_name: Virosztek
orcid: 0000-0003-1109-5511
citation:
ama: Geher GP, Titkos T, Virosztek D. Isometric study of Wasserstein spaces - the
real line. Transactions of the American Mathematical Society. 2020;373(8):5855-5883.
doi:10.1090/tran/8113
apa: Geher, G. P., Titkos, T., & Virosztek, D. (2020). Isometric study of Wasserstein
spaces - the real line. Transactions of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/tran/8113
chicago: Geher, Gyorgy Pal, Tamas Titkos, and Daniel Virosztek. “Isometric Study
of Wasserstein Spaces - the Real Line.” Transactions of the American Mathematical
Society. American Mathematical Society, 2020. https://doi.org/10.1090/tran/8113.
ieee: G. P. Geher, T. Titkos, and D. Virosztek, “Isometric study of Wasserstein
spaces - the real line,” Transactions of the American Mathematical Society,
vol. 373, no. 8. American Mathematical Society, pp. 5855–5883, 2020.
ista: Geher GP, Titkos T, Virosztek D. 2020. Isometric study of Wasserstein spaces
- the real line. Transactions of the American Mathematical Society. 373(8), 5855–5883.
mla: Geher, Gyorgy Pal, et al. “Isometric Study of Wasserstein Spaces - the Real
Line.” Transactions of the American Mathematical Society, vol. 373, no.
8, American Mathematical Society, 2020, pp. 5855–83, doi:10.1090/tran/8113.
short: G.P. Geher, T. Titkos, D. Virosztek, Transactions of the American Mathematical
Society 373 (2020) 5855–5883.
date_created: 2020-01-29T10:20:46Z
date_published: 2020-08-01T00:00:00Z
date_updated: 2023-08-17T14:31:03Z
day: '01'
ddc:
- '515'
department:
- _id: LaEr
doi: 10.1090/tran/8113
ec_funded: 1
external_id:
arxiv:
- '2002.00859'
isi:
- '000551418100018'
intvolume: ' 373'
isi: 1
issue: '8'
keyword:
- Wasserstein space
- isometric embeddings
- isometric rigidity
- exotic isometry flow
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.00859
month: '08'
oa: 1
oa_version: Preprint
page: 5855-5883
project:
- _id: 26A455A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '846294'
name: Geometric study of Wasserstein spaces and free probability
publication: Transactions of the American Mathematical Society
publication_identifier:
eissn:
- '10886850'
issn:
- '00029947'
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: Isometric study of Wasserstein spaces - the real line
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 373
year: '2020'
...
---
_id: '7467'
abstract:
- lang: eng
text: Nanomaterials produced from the bottom-up assembly of nanocrystals may incorporate
∼1020–1021 cm–3 not fully coordinated surface atoms, i.e., ∼1020–1021 cm–3 potential
donor or acceptor states that can strongly affect transport properties. Therefore,
to exploit the full potential of nanocrystal building blocks to produce functional
nanomaterials and thin films, a proper control of their surface chemistry is required.
Here, we analyze how the ligand stripping procedure influences the charge and
heat transport properties of sintered PbSe nanomaterials produced from the bottom-up
assembly of colloidal PbSe nanocrystals. First, we show that the removal of the
native organic ligands by thermal decomposition in an inert atmosphere leaves
relatively large amounts of carbon at the crystal interfaces. This carbon blocks
crystal growth during consolidation and at the same time hampers charge and heat
transport through the final nanomaterial. Second, we demonstrate that, by stripping
ligands from the nanocrystal surface before consolidation, nanomaterials with
larger crystal domains, lower porosity, and higher charge carrier concentrations
are obtained, thus resulting in nanomaterials with higher electrical and thermal
conductivities. In addition, the ligand displacement leaves the nanocrystal surface
unprotected, facilitating oxidation and chalcogen evaporation. The influence of
the ligand displacement on the nanomaterial charge transport properties is rationalized
here using a two-band model based on the standard Boltzmann transport equation
with the relaxation time approximation. Finally, we present an application of
the produced functional nanomaterials by modeling, fabricating, and testing a
simple PbSe-based thermoelectric device with a ring geometry.
acknowledgement: This work was supported by the Spanish Ministerio de Economía y Competitividad
through the project SEHTOP (ENE2016-77798-C4-3-R) and the Generalitat de Catalunya
through the project 2017SGR1246. D.C. acknowledges support from Universidad Nacional
de Colombia. Y.L. acknowledges funding from the European Union’s Horizon 2020 research
and innovation programme under the Marie Sklodowska-Curie grant agreement no. 754411.
M.I. acknowledges financial support from IST Austria.
article_processing_charge: No
article_type: original
author:
- first_name: Doris
full_name: Cadavid, Doris
last_name: Cadavid
- first_name: Silvia
full_name: Ortega, Silvia
last_name: Ortega
- first_name: Sergio
full_name: Illera, Sergio
last_name: Illera
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Alexey
full_name: Shavel, Alexey
last_name: Shavel
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Antonio M.
full_name: López, Antonio M.
last_name: López
- first_name: Germán
full_name: Noriega, Germán
last_name: Noriega
- first_name: Oscar Juan
full_name: Durá, Oscar Juan
last_name: Durá
- first_name: M. A.
full_name: López De La Torre, M. A.
last_name: López De La Torre
- first_name: Joan Daniel
full_name: Prades, Joan Daniel
last_name: Prades
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Cadavid D, Ortega S, Illera S, et al. Influence of the ligand stripping on
the transport properties of nanoparticle-based PbSe nanomaterials. ACS Applied
Energy Materials. 2020;3(3):2120-2129. doi:10.1021/acsaem.9b02137
apa: Cadavid, D., Ortega, S., Illera, S., Liu, Y., Ibáñez, M., Shavel, A., … Cabot,
A. (2020). Influence of the ligand stripping on the transport properties of nanoparticle-based
PbSe nanomaterials. ACS Applied Energy Materials. American Chemical Society.
https://doi.org/10.1021/acsaem.9b02137
chicago: Cadavid, Doris, Silvia Ortega, Sergio Illera, Yu Liu, Maria Ibáñez, Alexey
Shavel, Yu Zhang, et al. “Influence of the Ligand Stripping on the Transport Properties
of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials.
American Chemical Society, 2020. https://doi.org/10.1021/acsaem.9b02137.
ieee: D. Cadavid et al., “Influence of the ligand stripping on the transport
properties of nanoparticle-based PbSe nanomaterials,” ACS Applied Energy Materials,
vol. 3, no. 3. American Chemical Society, pp. 2120–2129, 2020.
ista: Cadavid D, Ortega S, Illera S, Liu Y, Ibáñez M, Shavel A, Zhang Y, Li M, López
AM, Noriega G, Durá OJ, López De La Torre MA, Prades JD, Cabot A. 2020. Influence
of the ligand stripping on the transport properties of nanoparticle-based PbSe
nanomaterials. ACS Applied Energy Materials. 3(3), 2120–2129.
mla: Cadavid, Doris, et al. “Influence of the Ligand Stripping on the Transport
Properties of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials,
vol. 3, no. 3, American Chemical Society, 2020, pp. 2120–29, doi:10.1021/acsaem.9b02137.
short: D. Cadavid, S. Ortega, S. Illera, Y. Liu, M. Ibáñez, A. Shavel, Y. Zhang,
M. Li, A.M. López, G. Noriega, O.J. Durá, M.A. López De La Torre, J.D. Prades,
A. Cabot, ACS Applied Energy Materials 3 (2020) 2120–2129.
date_created: 2020-02-09T23:00:52Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-08-17T14:36:16Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1021/acsaem.9b02137
ec_funded: 1
external_id:
isi:
- '000526598300012'
file:
- access_level: open_access
checksum: f23be731a766a480c77c962c1380315c
content_type: application/pdf
creator: dernst
date_created: 2022-08-23T08:34:17Z
date_updated: 2022-08-23T08:34:17Z
file_id: '11942'
file_name: 2020_ACSAppliedEnergyMat_Cadavid.pdf
file_size: 6423548
relation: main_file
success: 1
file_date_updated: 2022-08-23T08:34:17Z
has_accepted_license: '1'
intvolume: ' 3'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 2120-2129
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: ACS Applied Energy Materials
publication_identifier:
eissn:
- 2574-0962
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of the ligand stripping on the transport properties of nanoparticle-based
PbSe nanomaterials
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2020'
...
---
_id: '7465'
abstract:
- lang: eng
text: The flexible development of plants is characterized by a high capacity for
post-embryonic organ formation and tissue regeneration, processes, which require
tightly regulated intercellular communication and coordinated tissue (re-)polarization.
The phytohormone auxin, the main driver for these processes, is able to establish
polarized auxin transport channels, which are characterized by the expression
and polar, subcellular localization of the PIN1 auxin transport proteins. These
channels are demarcating the position of future vascular strands necessary for
organ formation and tissue regeneration. Major progress has been made in the last
years to understand how PINs can change their polarity in different contexts and
thus guide auxin flow through the plant. However, it still remains elusive how
auxin mediates the establishment of auxin conducting channels and the formation
of vascular tissue and which cellular processes are involved. By the means of
sophisticated regeneration experiments combined with local auxin applications
in Arabidopsis thaliana inflorescence stems we show that (i) PIN subcellular dynamics,
(ii) PIN internalization by clathrin-mediated trafficking and (iii) an intact
actin cytoskeleton required for post-endocytic trafficking are indispensable for
auxin channel formation, de novo vascular formation and vascular regeneration
after wounding. These observations provide novel insights into cellular mechanism
of coordinated tissue polarization during auxin canalization.
article_number: '110414'
article_processing_charge: No
article_type: original
author:
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Michelle C
full_name: Gallei, Michelle C
id: 35A03822-F248-11E8-B48F-1D18A9856A87
last_name: Gallei
orcid: 0000-0003-1286-7368
- first_name: Maciek
full_name: Adamowski, Maciek
id: 45F536D2-F248-11E8-B48F-1D18A9856A87
last_name: Adamowski
orcid: 0000-0001-6463-5257
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: Hélène S.
full_name: Robert, Hélène S.
last_name: Robert
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. Clathrin-mediated
trafficking and PIN trafficking are required for auxin canalization and vascular
tissue formation in Arabidopsis. Plant Science. 2020;293(4). doi:10.1016/j.plantsci.2020.110414
apa: Mazur, E., Gallei, M. C., Adamowski, M., Han, H., Robert, H. S., & Friml,
J. (2020). Clathrin-mediated trafficking and PIN trafficking are required for
auxin canalization and vascular tissue formation in Arabidopsis. Plant Science.
Elsevier. https://doi.org/10.1016/j.plantsci.2020.110414
chicago: Mazur, Ewa, Michelle C Gallei, Maciek Adamowski, Huibin Han, Hélène S.
Robert, and Jiří Friml. “Clathrin-Mediated Trafficking and PIN Trafficking Are
Required for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.”
Plant Science. Elsevier, 2020. https://doi.org/10.1016/j.plantsci.2020.110414.
ieee: E. Mazur, M. C. Gallei, M. Adamowski, H. Han, H. S. Robert, and J. Friml,
“Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization
and vascular tissue formation in Arabidopsis,” Plant Science, vol. 293,
no. 4. Elsevier, 2020.
ista: Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. 2020. Clathrin-mediated
trafficking and PIN trafficking are required for auxin canalization and vascular
tissue formation in Arabidopsis. Plant Science. 293(4), 110414.
mla: Mazur, Ewa, et al. “Clathrin-Mediated Trafficking and PIN Trafficking Are Required
for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.” Plant
Science, vol. 293, no. 4, 110414, Elsevier, 2020, doi:10.1016/j.plantsci.2020.110414.
short: E. Mazur, M.C. Gallei, M. Adamowski, H. Han, H.S. Robert, J. Friml, Plant
Science 293 (2020).
date_created: 2020-02-09T23:00:50Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2023-08-17T14:37:32Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.plantsci.2020.110414
ec_funded: 1
external_id:
isi:
- '000520609800009'
file:
- access_level: open_access
checksum: f7f27c6a8fea985ceb9279be2204461c
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:59:36Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7471'
file_name: 2020_PlantScience_Mazur.pdf
file_size: 3499069
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 293'
isi: 1
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: Plant Science
publication_identifier:
eissn:
- '18732259'
issn:
- '01689452'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '11626'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization
and vascular tissue formation in Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 293
year: '2020'
...
---
_id: '7466'
abstract:
- lang: eng
text: Unpaired ligands are secreted signals that act via a GP130-like receptor,
domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines,
unpaireds can be activated by infection and other stresses and can promote insulin
resistance in target tissues. However, the importance of this effect in non-inflammatory
physiology is unknown. Here, we identify a requirement for unpaired-JAK signalling
as a metabolic regulator in healthy adult Drosophila muscle. Adult muscles show
basal JAK-STAT signalling activity in the absence of any immune challenge. Plasmatocytes
(Drosophila macrophages) are an important source of this tonic signal. Loss of
the dome receptor on adult muscles significantly reduces lifespan and causes local
and systemic metabolic pathology. These pathologies result from hyperactivation
of AKT and consequent deregulation of metabolism. Thus, we identify a cytokine
signal that must be received in muscle to control AKT activity and metabolic homeostasis.
article_number: e51595
article_processing_charge: No
article_type: original
author:
- first_name: Katrin
full_name: Kierdorf, Katrin
last_name: Kierdorf
- first_name: Fabian
full_name: Hersperger, Fabian
last_name: Hersperger
- first_name: Jessica
full_name: Sharrock, Jessica
last_name: Sharrock
- first_name: Crystal M.
full_name: Vincent, Crystal M.
last_name: Vincent
- first_name: Pinar
full_name: Ustaoglu, Pinar
last_name: Ustaoglu
- first_name: Jiawen
full_name: Dou, Jiawen
last_name: Dou
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Olaf
full_name: Groß, Olaf
last_name: Groß
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Marc S.
full_name: Dionne, Marc S.
last_name: Dionne
citation:
ama: Kierdorf K, Hersperger F, Sharrock J, et al. Muscle function and homeostasis
require cytokine inhibition of AKT activity in Drosophila. eLife. 2020;9.
doi:10.7554/eLife.51595
apa: Kierdorf, K., Hersperger, F., Sharrock, J., Vincent, C. M., Ustaoglu, P., Dou,
J., … Dionne, M. S. (2020). Muscle function and homeostasis require cytokine inhibition
of AKT activity in Drosophila. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.51595
chicago: Kierdorf, Katrin, Fabian Hersperger, Jessica Sharrock, Crystal M. Vincent,
Pinar Ustaoglu, Jiawen Dou, Attila György, Olaf Groß, Daria E Siekhaus, and Marc
S. Dionne. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT
Activity in Drosophila.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.51595.
ieee: K. Kierdorf et al., “Muscle function and homeostasis require cytokine
inhibition of AKT activity in Drosophila,” eLife, vol. 9. eLife Sciences
Publications, 2020.
ista: Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, György
A, Groß O, Siekhaus DE, Dionne MS. 2020. Muscle function and homeostasis require
cytokine inhibition of AKT activity in Drosophila. eLife. 9, e51595.
mla: Kierdorf, Katrin, et al. “Muscle Function and Homeostasis Require Cytokine
Inhibition of AKT Activity in Drosophila.” ELife, vol. 9, e51595, eLife
Sciences Publications, 2020, doi:10.7554/eLife.51595.
short: K. Kierdorf, F. Hersperger, J. Sharrock, C.M. Vincent, P. Ustaoglu, J. Dou,
A. György, O. Groß, D.E. Siekhaus, M.S. Dionne, ELife 9 (2020).
date_created: 2020-02-09T23:00:51Z
date_published: 2020-01-20T00:00:00Z
date_updated: 2023-08-17T14:36:39Z
day: '20'
ddc:
- '570'
department:
- _id: DaSi
doi: 10.7554/eLife.51595
external_id:
isi:
- '000512304800001'
file:
- access_level: open_access
checksum: 3a072be843f416c7a7d532a51dc0addb
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:53:16Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7470'
file_name: 2020_eLife_Kierdorf.pdf
file_size: 4959933
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: Drosophila TNFa´s Funktion in Immunzellen
publication: eLife
publication_identifier:
eissn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Muscle function and homeostasis require cytokine inhibition of AKT activity
in Drosophila
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '7472'
abstract:
- lang: eng
text: Temporally organized reactivation of experiences during awake immobility periods
is thought to underlie cognitive processes like planning and evaluation. While
replay of trajectories is well established for the hippocampus, it is unclear
whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral
experiences in the awake state to support task execution. We simultaneously recorded
from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent
rule-switching task on a plus maze. We found that mPFC neuronal activity encoded
relative positions between the start and goal. During awake immobility periods,
the mPFC replayed temporally organized sequences of these generalized positions,
resembling entire spatial trajectories. The occurrence of mPFC trajectory replay
positively correlated with rule-switching performance. However, hippocampal and
mPFC trajectory replay occurred independently, indicating different functions.
These results demonstrate that the mPFC can replay ordered activity patterns representing
generalized locations and suggest that mPFC replay might have a role in flexible
behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for
the drive design and production, Hugo Malagon-Vina for assistance in maze automatization,
Jago Wallenschus for taking the images of the histology, and Federico Stella and
Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript.
This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).
article_processing_charge: No
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karel
full_name: Blahna, Karel
id: 3EA859AE-F248-11E8-B48F-1D18A9856A87
last_name: Blahna
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in
the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6.
doi:10.1016/j.neuron.2020.01.015
apa: Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of
behavioral sequences in the medial prefrontal cortex during rule switching. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015
chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay
of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.”
Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015.
ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral
sequences in the medial prefrontal cortex during rule switching,” Neuron,
vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.
ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences
in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.
mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal
Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020,
p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015.
short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.
date_created: 2020-02-10T15:45:48Z
date_published: 2020-04-08T00:00:00Z
date_updated: 2023-08-17T14:38:02Z
day: '08'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.015
ec_funded: 1
external_id:
isi:
- '000525319300016'
pmid:
- '32032512'
intvolume: ' 106'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.015
month: '04'
oa: 1
oa_version: Published Version
page: P154-165.e6
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/
scopus_import: '1'
status: public
title: Replay of behavioral sequences in the medial prefrontal cortex during rule
switching
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '7388'
abstract:
- lang: eng
text: We give a Wong-Zakai type characterisation of the solutions of quasilinear
heat equations driven by space-time white noise in 1 + 1 dimensions. In order
to show that the renormalisation counterterms are local in the solution, a careful
arrangement of a few hundred terms is required. The main tool in this computation
is a general ‘integration by parts’ formula that provides a number of linear identities
for the renormalisation constants.
article_processing_charge: No
article_type: original
author:
- first_name: Mate
full_name: Gerencser, Mate
id: 44ECEDF2-F248-11E8-B48F-1D18A9856A87
last_name: Gerencser
citation:
ama: Gerencser M. Nondivergence form quasilinear heat equations driven by space-time
white noise. Annales de l’Institut Henri Poincaré C, Analyse non linéaire.
2020;37(3):663-682. doi:10.1016/j.anihpc.2020.01.003
apa: Gerencser, M. (2020). Nondivergence form quasilinear heat equations driven
by space-time white noise. Annales de l’Institut Henri Poincaré C, Analyse
Non Linéaire. Elsevier. https://doi.org/10.1016/j.anihpc.2020.01.003
chicago: Gerencser, Mate. “Nondivergence Form Quasilinear Heat Equations Driven
by Space-Time White Noise.” Annales de l’Institut Henri Poincaré C, Analyse
Non Linéaire. Elsevier, 2020. https://doi.org/10.1016/j.anihpc.2020.01.003.
ieee: M. Gerencser, “Nondivergence form quasilinear heat equations driven by space-time
white noise,” Annales de l’Institut Henri Poincaré C, Analyse non linéaire,
vol. 37, no. 3. Elsevier, pp. 663–682, 2020.
ista: Gerencser M. 2020. Nondivergence form quasilinear heat equations driven by
space-time white noise. Annales de l’Institut Henri Poincaré C, Analyse non linéaire.
37(3), 663–682.
mla: Gerencser, Mate. “Nondivergence Form Quasilinear Heat Equations Driven by Space-Time
White Noise.” Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire,
vol. 37, no. 3, Elsevier, 2020, pp. 663–82, doi:10.1016/j.anihpc.2020.01.003.
short: M. Gerencser, Annales de l’Institut Henri Poincaré C, Analyse Non Linéaire
37 (2020) 663–682.
date_created: 2020-01-29T09:39:41Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-08-17T14:35:46Z
day: '01'
department:
- _id: JaMa
doi: 10.1016/j.anihpc.2020.01.003
external_id:
arxiv:
- '1902.07635'
isi:
- '000531049800007'
intvolume: ' 37'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.07635
month: '05'
oa: 1
oa_version: Preprint
page: 663-682
publication: Annales de l'Institut Henri Poincaré C, Analyse non linéaire
publication_identifier:
issn:
- 0294-1449
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nondivergence form quasilinear heat equations driven by space-time white noise
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 37
year: '2020'
...
---
_id: '7487'
abstract:
- lang: eng
text: 'Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis
playing a key role in cancer metabolic reprogramming. Humans express two types
of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell
proliferation, but the role of GLS2 in cancer remains poorly understood. GLS2
is repressed in many tumor cells and a better understanding of its function in
tumorigenesis may further the development of new therapeutic approaches. We analyzed
GLS2 expression in HCC, GBM and neuroblastoma cells, as well as in monkey COS-7
cells. We studied GLS2 expression after induction of differentiation with phorbol
ester (PMA) and transduction with the full-length cDNA of GLS2. In parallel, we
investigated cell cycle progression and levels of p53, p21 and c-Myc proteins.
Using the baculovirus system, human GLS2 protein was overexpressed, purified and
analyzed for posttranslational modifications employing a proteomics LC-MS/MS platform.
We have demonstrated a dual targeting of GLS2 in human cancer cells. Immunocytochemistry
and subcellular fractionation gave consistent results demonstrating nuclear and
mitochondrial locations, with the latter being predominant. Nuclear targeting
was confirmed in cancer cells overexpressing c-Myc- and GFP-tagged GLS2 proteins.
We assessed the subnuclear location finding a widespread distribution of GLS2
in the nucleoplasm without clear overlapping with specific nuclear substructures.
GLS2 expression and nuclear accrual notably increased by treatment of SH-SY5Y
cells with PMA and it correlated with cell cycle arrest at G2/M, upregulation
of tumor suppressor p53 and p21 protein. A similar response was obtained by overexpression
of GLS2 in T98G glioma cells, including downregulation of oncogene c-Myc. Furthermore,
human GLS2 was identified as being hypusinated by MS analysis, a posttranslational
modification which may be relevant for its nuclear targeting and/or function.
Our studies provide evidence for a tumor suppressor role of GLS2 in certain types
of cancer. The data imply that GLS2 can be regarded as a highly mobile and multilocalizing
protein translocated to both mitochondria and nuclei. Upregulation of GLS2 in
cancer cells induced an antiproliferative response with cell cycle arrest at the
G2/M phase.'
article_number: '2259'
article_processing_charge: No
article_type: original
author:
- first_name: Amada R.
full_name: López De La Oliva, Amada R.
last_name: López De La Oliva
- first_name: José A.
full_name: Campos-Sandoval, José A.
last_name: Campos-Sandoval
- first_name: María C.
full_name: Gómez-García, María C.
last_name: Gómez-García
- first_name: Carolina
full_name: Cardona, Carolina
last_name: Cardona
- first_name: Mercedes
full_name: Martín-Rufián, Mercedes
last_name: Martín-Rufián
- first_name: Fernando J.
full_name: Sialana, Fernando J.
last_name: Sialana
- first_name: Laura
full_name: Castilla, Laura
last_name: Castilla
- first_name: Narkhyun
full_name: Bae, Narkhyun
id: 3A5F7CD8-F248-11E8-B48F-1D18A9856A87
last_name: Bae
- first_name: Carolina
full_name: Lobo, Carolina
last_name: Lobo
- first_name: Ana
full_name: Peñalver, Ana
last_name: Peñalver
- first_name: Marina
full_name: García-Frutos, Marina
last_name: García-Frutos
- first_name: David
full_name: Carro, David
last_name: Carro
- first_name: Victoria
full_name: Enrique, Victoria
last_name: Enrique
- first_name: José C.
full_name: Paz, José C.
last_name: Paz
- first_name: Raghavendra G.
full_name: Mirmira, Raghavendra G.
last_name: Mirmira
- first_name: Antonia
full_name: Gutiérrez, Antonia
last_name: Gutiérrez
- first_name: Francisco J.
full_name: Alonso, Francisco J.
last_name: Alonso
- first_name: Juan A.
full_name: Segura, Juan A.
last_name: Segura
- first_name: José M.
full_name: Matés, José M.
last_name: Matés
- first_name: Gert
full_name: Lubec, Gert
last_name: Lubec
- first_name: Javier
full_name: Márquez, Javier
last_name: Márquez
citation:
ama: López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, et al. Nuclear translocation
of glutaminase GLS2 in human cancer cells associates with proliferation arrest
and differentiation. Scientific reports. 2020;10(1). doi:10.1038/s41598-020-58264-4
apa: López De La Oliva, A. R., Campos-Sandoval, J. A., Gómez-García, M. C., Cardona,
C., Martín-Rufián, M., Sialana, F. J., … Márquez, J. (2020). Nuclear translocation
of glutaminase GLS2 in human cancer cells associates with proliferation arrest
and differentiation. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-020-58264-4
chicago: López De La Oliva, Amada R., José A. Campos-Sandoval, María C. Gómez-García,
Carolina Cardona, Mercedes Martín-Rufián, Fernando J. Sialana, Laura Castilla,
et al. “Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates
with Proliferation Arrest and Differentiation.” Scientific Reports. Springer
Nature, 2020. https://doi.org/10.1038/s41598-020-58264-4.
ieee: A. R. López De La Oliva et al., “Nuclear translocation of glutaminase
GLS2 in human cancer cells associates with proliferation arrest and differentiation,”
Scientific reports, vol. 10, no. 1. Springer Nature, 2020.
ista: López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián
M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D,
Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec
G, Márquez J. 2020. Nuclear translocation of glutaminase GLS2 in human cancer
cells associates with proliferation arrest and differentiation. Scientific reports.
10(1), 2259.
mla: López De La Oliva, Amada R., et al. “Nuclear Translocation of Glutaminase GLS2
in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.”
Scientific Reports, vol. 10, no. 1, 2259, Springer Nature, 2020, doi:10.1038/s41598-020-58264-4.
short: A.R. López De La Oliva, J.A. Campos-Sandoval, M.C. Gómez-García, C. Cardona,
M. Martín-Rufián, F.J. Sialana, L. Castilla, N. Bae, C. Lobo, A. Peñalver, M.
García-Frutos, D. Carro, V. Enrique, J.C. Paz, R.G. Mirmira, A. Gutiérrez, F.J.
Alonso, J.A. Segura, J.M. Matés, G. Lubec, J. Márquez, Scientific Reports 10 (2020).
date_created: 2020-02-16T23:00:49Z
date_published: 2020-02-10T00:00:00Z
date_updated: 2023-08-18T06:35:13Z
day: '10'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.1038/s41598-020-58264-4
external_id:
isi:
- '000560694800012'
pmid:
- '32042057'
file:
- access_level: open_access
checksum: c780bd87476a9c9e12668ff66de3dc96
content_type: application/pdf
creator: dernst
date_created: 2020-02-18T07:43:21Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7495'
file_name: 2020_ScientificReport_Lopez.pdf
file_size: 4703751
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific reports
publication_identifier:
eissn:
- '20452322'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41598-020-80651-0
scopus_import: '1'
status: public
title: Nuclear translocation of glutaminase GLS2 in human cancer cells associates
with proliferation arrest and differentiation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...
---
_id: '7490'
abstract:
- lang: eng
text: In plants, clathrin mediated endocytosis (CME) represents the major route
for cargo internalisation from the cell surface. It has been assumed to operate
in an evolutionary conserved manner as in yeast and animals. Here we report characterisation
of ultrastructure, dynamics and mechanisms of plant CME as allowed by our advancement
in electron microscopy and quantitative live imaging techniques. Arabidopsis CME
appears to follow the constant curvature model and the bona fide CME population
generates vesicles of a predominantly hexagonal-basket type; larger and with faster
kinetics than in other models. Contrary to the existing paradigm, actin is dispensable
for CME events at the plasma membrane but plays a unique role in collecting endocytic
vesicles, sorting of internalised cargos and directional endosome movement that
itself actively promote CME events. Internalized vesicles display a strongly delayed
and sequential uncoating. These unique features highlight the independent evolution
of the plant CME mechanism during the autonomous rise of multicellularity in eukaryotes.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
article_number: e52067
article_processing_charge: No
article_type: original
author:
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Narasimhan M, Johnson AJ, Prizak R, et al. Evolutionarily unique mechanistic
framework of clathrin-mediated endocytosis in plants. eLife. 2020;9. doi:10.7554/eLife.52067
apa: Narasimhan, M., Johnson, A. J., Prizak, R., Kaufmann, W., Tan, S., Casillas
Perez, B. E., & Friml, J. (2020). Evolutionarily unique mechanistic framework
of clathrin-mediated endocytosis in plants. ELife. eLife Sciences Publications.
https://doi.org/10.7554/eLife.52067
chicago: Narasimhan, Madhumitha, Alexander J Johnson, Roshan Prizak, Walter Kaufmann,
Shutang Tan, Barbara E Casillas Perez, and Jiří Friml. “Evolutionarily Unique
Mechanistic Framework of Clathrin-Mediated Endocytosis in Plants.” ELife.
eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.52067.
ieee: M. Narasimhan et al., “Evolutionarily unique mechanistic framework
of clathrin-mediated endocytosis in plants,” eLife, vol. 9. eLife Sciences
Publications, 2020.
ista: Narasimhan M, Johnson AJ, Prizak R, Kaufmann W, Tan S, Casillas Perez BE,
Friml J. 2020. Evolutionarily unique mechanistic framework of clathrin-mediated
endocytosis in plants. eLife. 9, e52067.
mla: Narasimhan, Madhumitha, et al. “Evolutionarily Unique Mechanistic Framework
of Clathrin-Mediated Endocytosis in Plants.” ELife, vol. 9, e52067, eLife
Sciences Publications, 2020, doi:10.7554/eLife.52067.
short: M. Narasimhan, A.J. Johnson, R. Prizak, W. Kaufmann, S. Tan, B.E. Casillas
Perez, J. Friml, ELife 9 (2020).
date_created: 2020-02-16T23:00:50Z
date_published: 2020-01-23T00:00:00Z
date_updated: 2023-08-18T06:33:07Z
day: '23'
ddc:
- '570'
- '580'
department:
- _id: JiFr
- _id: GaTk
- _id: EM-Fac
- _id: SyCr
doi: 10.7554/eLife.52067
ec_funded: 1
external_id:
isi:
- '000514104100001'
pmid:
- '31971511'
file:
- access_level: open_access
checksum: 2052daa4be5019534f3a42f200a09f32
content_type: application/pdf
creator: dernst
date_created: 2020-02-18T07:21:16Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7494'
file_name: 2020_eLife_Narasimhan.pdf
file_size: 7247468
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis
in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '7488'
abstract:
- lang: eng
text: Characteristic or classic phenotype of Cornelia de Lange syndrome (CdLS) is
associated with a recognisable facial pattern. However, the heterogeneity in causal
genes and the presence of overlapping syndromes have made it increasingly difficult
to diagnose only by clinical features. DeepGestalt technology, and its app Face2Gene,
is having a growing impact on the diagnosis and management of genetic diseases
by analysing the features of affected individuals. Here, we performed a phenotypic
study on a cohort of 49 individuals harbouring causative variants in known CdLS
genes in order to evaluate Face2Gene utility and sensitivity in the clinical diagnosis
of CdLS. Based on the profile images of patients, a diagnosis of CdLS was within
the top five predicted syndromes for 97.9% of our cases and even listed as first
prediction for 83.7%. The age of patients did not seem to affect the prediction
accuracy, whereas our results indicate a correlation between the clinical score
and affected genes. Furthermore, each gene presents a different pattern recognition
that may be used to develop new neural networks with the goal of separating different
genetic subtypes in CdLS. Overall, we conclude that computer-assisted image analysis
based on deep learning could support the clinical diagnosis of CdLS.
article_number: '1042'
article_processing_charge: No
article_type: original
author:
- first_name: Ana
full_name: Latorre-Pellicer, Ana
last_name: Latorre-Pellicer
- first_name: Ángela
full_name: Ascaso, Ángela
last_name: Ascaso
- first_name: Laura
full_name: Trujillano, Laura
last_name: Trujillano
- first_name: Marta
full_name: Gil-Salvador, Marta
last_name: Gil-Salvador
- first_name: Maria
full_name: Arnedo, Maria
last_name: Arnedo
- first_name: Cristina
full_name: Lucia-Campos, Cristina
last_name: Lucia-Campos
- first_name: Rebeca
full_name: Antoñanzas-Pérez, Rebeca
last_name: Antoñanzas-Pérez
- first_name: Iñigo
full_name: Marcos-Alcalde, Iñigo
last_name: Marcos-Alcalde
- first_name: Ilaria
full_name: Parenti, Ilaria
id: D93538B0-5B71-11E9-AC62-02EBE5697425
last_name: Parenti
- first_name: Gloria
full_name: Bueno-Lozano, Gloria
last_name: Bueno-Lozano
- first_name: Antonio
full_name: Musio, Antonio
last_name: Musio
- first_name: Beatriz
full_name: Puisac, Beatriz
last_name: Puisac
- first_name: Frank J.
full_name: Kaiser, Frank J.
last_name: Kaiser
- first_name: Feliciano J.
full_name: Ramos, Feliciano J.
last_name: Ramos
- first_name: Paulino
full_name: Gómez-Puertas, Paulino
last_name: Gómez-Puertas
- first_name: Juan
full_name: Pié, Juan
last_name: Pié
citation:
ama: Latorre-Pellicer A, Ascaso Á, Trujillano L, et al. Evaluating Face2Gene as
a tool to identify Cornelia de Lange syndrome by facial phenotypes. International
Journal of Molecular Sciences. 2020;21(3). doi:10.3390/ijms21031042
apa: Latorre-Pellicer, A., Ascaso, Á., Trujillano, L., Gil-Salvador, M., Arnedo,
M., Lucia-Campos, C., … Pié, J. (2020). Evaluating Face2Gene as a tool to identify
Cornelia de Lange syndrome by facial phenotypes. International Journal of Molecular
Sciences. MDPI. https://doi.org/10.3390/ijms21031042
chicago: Latorre-Pellicer, Ana, Ángela Ascaso, Laura Trujillano, Marta Gil-Salvador,
Maria Arnedo, Cristina Lucia-Campos, Rebeca Antoñanzas-Pérez, et al. “Evaluating
Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes.”
International Journal of Molecular Sciences. MDPI, 2020. https://doi.org/10.3390/ijms21031042.
ieee: A. Latorre-Pellicer et al., “Evaluating Face2Gene as a tool to identify
Cornelia de Lange syndrome by facial phenotypes,” International Journal of
Molecular Sciences, vol. 21, no. 3. MDPI, 2020.
ista: Latorre-Pellicer A, Ascaso Á, Trujillano L, Gil-Salvador M, Arnedo M, Lucia-Campos
C, Antoñanzas-Pérez R, Marcos-Alcalde I, Parenti I, Bueno-Lozano G, Musio A, Puisac
B, Kaiser FJ, Ramos FJ, Gómez-Puertas P, Pié J. 2020. Evaluating Face2Gene as
a tool to identify Cornelia de Lange syndrome by facial phenotypes. International
Journal of Molecular Sciences. 21(3), 1042.
mla: Latorre-Pellicer, Ana, et al. “Evaluating Face2Gene as a Tool to Identify Cornelia
de Lange Syndrome by Facial Phenotypes.” International Journal of Molecular
Sciences, vol. 21, no. 3, 1042, MDPI, 2020, doi:10.3390/ijms21031042.
short: A. Latorre-Pellicer, Á. Ascaso, L. Trujillano, M. Gil-Salvador, M. Arnedo,
C. Lucia-Campos, R. Antoñanzas-Pérez, I. Marcos-Alcalde, I. Parenti, G. Bueno-Lozano,
A. Musio, B. Puisac, F.J. Kaiser, F.J. Ramos, P. Gómez-Puertas, J. Pié, International
Journal of Molecular Sciences 21 (2020).
date_created: 2020-02-16T23:00:49Z
date_published: 2020-02-04T00:00:00Z
date_updated: 2023-08-18T06:35:41Z
day: '04'
ddc:
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doi: 10.3390/ijms21031042
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oa_version: Published Version
publication: International Journal of Molecular Sciences
publication_identifier:
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issn:
- '16616596'
publication_status: published
publisher: MDPI
quality_controlled: '1'
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status: public
title: Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial
phenotypes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
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...
---
_id: '7505'
abstract:
- lang: eng
text: Neural networks have demonstrated unmatched performance in a range of classification
tasks. Despite numerous efforts of the research community, novelty detection remains
one of the significant limitations of neural networks. The ability to identify
previously unseen inputs as novel is crucial for our understanding of the decisions
made by neural networks. At runtime, inputs not falling into any of the categories
learned during training cannot be classified correctly by the neural network.
Existing approaches treat the neural network as a black box and try to detect
novel inputs based on the confidence of the output predictions. However, neural
networks are not trained to reduce their confidence for novel inputs, which limits
the effectiveness of these approaches. We propose a framework to monitor a neural
network by observing the hidden layers. We employ a common abstraction from program
analysis - boxes - to identify novel behaviors in the monitored layers, i.e.,
inputs that cause behaviors outside the box. For each neuron, the boxes range
over the values seen in training. The framework is efficient and flexible to achieve
a desired trade-off between raising false warnings and detecting novel inputs.
We illustrate the performance and the robustness to variability in the unknown
classes on popular image-classification benchmarks.
acknowledgement: We thank Christoph Lampert and Nikolaus Mayer for fruitful discussions.
This research was supported in part by the Austrian Science Fund (FWF) under grants
S11402-N23 (RiSE/SHiNE) and Z211-N23 (Wittgenstein Award) and the European Union’s
Horizon 2020 research and innovation programme under the Marie SkłodowskaCurie grant
agreement No. 754411.
alternative_title:
- Frontiers in Artificial Intelligence and Applications
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Anna
full_name: Lukina, Anna
id: CBA4D1A8-0FE8-11E9-BDE6-07BFE5697425
last_name: Lukina
- first_name: Christian
full_name: Schilling, Christian
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
citation:
ama: 'Henzinger TA, Lukina A, Schilling C. Outside the box: Abstraction-based monitoring
of neural networks. In: 24th European Conference on Artificial Intelligence.
Vol 325. IOS Press; 2020:2433-2440. doi:10.3233/FAIA200375'
apa: 'Henzinger, T. A., Lukina, A., & Schilling, C. (2020). Outside the box:
Abstraction-based monitoring of neural networks. In 24th European Conference
on Artificial Intelligence (Vol. 325, pp. 2433–2440). Santiago de Compostela,
Spain: IOS Press. https://doi.org/10.3233/FAIA200375'
chicago: 'Henzinger, Thomas A, Anna Lukina, and Christian Schilling. “Outside the
Box: Abstraction-Based Monitoring of Neural Networks.” In 24th European Conference
on Artificial Intelligence, 325:2433–40. IOS Press, 2020. https://doi.org/10.3233/FAIA200375.'
ieee: 'T. A. Henzinger, A. Lukina, and C. Schilling, “Outside the box: Abstraction-based
monitoring of neural networks,” in 24th European Conference on Artificial Intelligence,
Santiago de Compostela, Spain, 2020, vol. 325, pp. 2433–2440.'
ista: 'Henzinger TA, Lukina A, Schilling C. 2020. Outside the box: Abstraction-based
monitoring of neural networks. 24th European Conference on Artificial Intelligence.
ECAI: European Conference on Artificial Intelligence, Frontiers in Artificial
Intelligence and Applications, vol. 325, 2433–2440.'
mla: 'Henzinger, Thomas A., et al. “Outside the Box: Abstraction-Based Monitoring
of Neural Networks.” 24th European Conference on Artificial Intelligence,
vol. 325, IOS Press, 2020, pp. 2433–40, doi:10.3233/FAIA200375.'
short: T.A. Henzinger, A. Lukina, C. Schilling, in:, 24th European Conference on
Artificial Intelligence, IOS Press, 2020, pp. 2433–2440.
conference:
end_date: 2020-09-08
location: Santiago de Compostela, Spain
name: 'ECAI: European Conference on Artificial Intelligence'
start_date: 2020-08-29
date_created: 2020-02-21T16:44:03Z
date_published: 2020-02-24T00:00:00Z
date_updated: 2023-08-18T06:38:16Z
day: '24'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.3233/FAIA200375
ec_funded: 1
external_id:
arxiv:
- '1911.09032'
isi:
- '000650971303002'
file:
- access_level: open_access
checksum: 80642fa0b6cd7da95dcd87d63789ad5e
content_type: application/pdf
creator: dernst
date_created: 2020-09-21T07:12:32Z
date_updated: 2020-09-21T07:12:32Z
file_id: '8540'
file_name: 2020_ECAI_Henzinger.pdf
file_size: 1692214
relation: main_file
success: 1
file_date_updated: 2020-09-21T07:12:32Z
has_accepted_license: '1'
intvolume: ' 325'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 2433-2440
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: 24th European Conference on Artificial Intelligence
publication_status: published
publisher: IOS Press
quality_controlled: '1'
status: public
title: 'Outside the box: Abstraction-based monitoring of neural networks'
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 325
year: '2020'
...