TY - JOUR AB - We study the Fröhlich polaron model in R3, and establish the subleading term in the strong coupling asymptotics of its ground state energy, corresponding to the quantum corrections to the classical energy determined by the Pekar approximation. AU - Brooks, Morris AU - Seiringer, Robert ID - 14441 JF - Communications in Mathematical Physics SN - 0010-3616 TI - The Fröhlich Polaron at strong coupling: Part I - The quantum correction to the classical energy VL - 404 ER - TY - CONF AB - We consider the problem of solving LP relaxations of MAP-MRF inference problems, and in particular the method proposed recently in [16], [35]. As a key computational subroutine, it uses a variant of the Frank-Wolfe (FW) method to minimize a smooth convex function over a combinatorial polytope. We propose an efficient implementation of this subroutine based on in-face Frank-Wolfe directions, introduced in [4] in a different context. More generally, we define an abstract data structure for a combinatorial subproblem that enables in-face FW directions, and describe its specialization for tree-structured MAP-MRF inference subproblems. Experimental results indicate that the resulting method is the current state-of-art LP solver for some classes of problems. Our code is available at pub.ist.ac.at/~vnk/papers/IN-FACE-FW.html. AU - Kolmogorov, Vladimir ID - 14448 SN - 1063-6919 T2 - Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition TI - Solving relaxations of MAP-MRF problems: Combinatorial in-face Frank-Wolfe directions VL - 2023 ER - TY - JOUR AB - Cytosine methylation within CG dinucleotides (mCG) can be epigenetically inherited over many generations. Such inheritance is thought to be mediated by a semiconservative mechanism that produces binary present/absent methylation patterns. However, we show here that in Arabidopsis thaliana h1ddm1 mutants, intermediate heterochromatic mCG is stably inherited across many generations and is quantitatively associated with transposon expression. We develop a mathematical model that estimates the rates of semiconservative maintenance failure and de novo methylation at each transposon, demonstrating that mCG can be stably inherited at any level via a dynamic balance of these activities. We find that DRM2 – the core methyltransferase of the RNA-directed DNA methylation pathway – catalyzes most of the heterochromatic de novo mCG, with de novo rates orders of magnitude higher than previously thought, whereas chromomethylases make smaller contributions. Our results demonstrate that stable epigenetic inheritance of mCG in plant heterochromatin is enabled by extensive de novo methylation. AU - Lyons, David B. AU - Briffa, Amy AU - He, Shengbo AU - Choi, Jaemyung AU - Hollwey, Elizabeth AU - Colicchio, Jack AU - Anderson, Ian AU - Feng, Xiaoqi AU - Howard, Martin AU - Zilberman, Daniel ID - 12672 IS - 3 JF - Cell Reports TI - Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons VL - 42 ER - TY - JOUR AB - We consider the large polaron described by the Fröhlich Hamiltonian and study its energy-momentum relation defined as the lowest possible energy as a function of the total momentum. Using a suitable family of trial states, we derive an optimal parabolic upper bound for the energy-momentum relation in the limit of strong coupling. The upper bound consists of a momentum independent term that agrees with the predicted two-term expansion for the ground state energy of the strongly coupled polaron at rest and a term that is quadratic in the momentum with coefficient given by the inverse of twice the classical effective mass introduced by Landau and Pekar. AU - Mitrouskas, David Johannes AU - Mysliwy, Krzysztof AU - Seiringer, Robert ID - 13178 JF - Forum of Mathematics TI - Optimal parabolic upper bound for the energy-momentum relation of a strongly coupled polaron VL - 11 ER - TY - JOUR AB - Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling. AU - Kicheva, Anna AU - Briscoe, James ID - 14484 JF - Annual Review of Cell and Developmental Biology SN - 1081-0706 TI - Control of tissue development by morphogens VL - 39 ER -