[{"quality_controlled":0,"page":"1 - 10","main_file_link":[{"open_access":"0","url":"http://arxiv.org/abs/1105.6257"}],"citation":{"chicago":"Čadek, Martin, Marek Krcál, Jiří Matoušek, Francis Sergeraert, Lukáš Vokřínek, and Uli Wagner. “Computing All Maps into a Sphere,” 1–10. SIAM, 2012.","mla":"Čadek, Martin, et al. Computing All Maps into a Sphere. SIAM, 2012, pp. 1–10.","short":"M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, U. Wagner, in:, SIAM, 2012, pp. 1–10.","ista":"Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. 2012. Computing all maps into a sphere. SODA: Symposium on Discrete Algorithms, 1–10.","ieee":"M. Čadek, M. Krcál, J. Matoušek, F. Sergeraert, L. Vokřínek, and U. Wagner, “Computing all maps into a sphere,” presented at the SODA: Symposium on Discrete Algorithms, 2012, pp. 1–10.","apa":"Čadek, M., Krcál, M., Matoušek, J., Sergeraert, F., Vokřínek, L., & Wagner, U. (2012). Computing all maps into a sphere (pp. 1–10). Presented at the SODA: Symposium on Discrete Algorithms, SIAM.","ama":"Čadek M, Krcál M, Matoušek J, Sergeraert F, Vokřínek L, Wagner U. Computing all maps into a sphere. In: SIAM; 2012:1-10."},"conference":{"name":"SODA: Symposium on Discrete Algorithms"},"date_published":"2012-01-01T00:00:00Z","day":"01","month":"01","publication_status":"published","status":"public","title":"Computing all maps into a sphere","publisher":"SIAM","_id":"2440","year":"2012","date_updated":"2021-01-12T06:57:30Z","date_created":"2018-12-11T11:57:40Z","author":[{"full_name":"Čadek, Martin","first_name":"Martin","last_name":"Čadek"},{"full_name":"Marek Krcál","first_name":"Marek","last_name":"Krcál","id":"33E21118-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Matoušek, Jiří","last_name":"Matoušek","first_name":"Jiří"},{"full_name":"Sergeraert, Francis","first_name":"Francis","last_name":"Sergeraert"},{"full_name":"Vokřínek, Lukáš","last_name":"Vokřínek","first_name":"Lukáš"},{"full_name":"Uli Wagner","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","first_name":"Uli"}],"type":"conference","extern":1,"abstract":[{"text":"We present an algorithm for computing [X, Y], i.e., all homotopy classes of continuous maps X → Y, where X, Y are topological spaces given as finite simplicial complexes, Y is (d - 1)-connected for some d ≥ 2 (for example, Y can be the d-dimensional sphere S d), and dim X ≤ 2d - 2. These conditions on X, Y guarantee that [X, Y] has a natural structure of a finitely generated Abelian group, and the algorithm finds generators and relations for it. We combine several tools and ideas from homotopy theory (such as Postnikov systems, simplicial sets, and obstruction theory) with algorithmic tools from effective algebraic topology (objects with effective homology). We hope that a further extension of the methods developed here will yield an algorithm for computing, in some cases of interest, the ℤ 2-index, which is a quantity playing a prominent role in Borsuk-Ulam style applications of topology in combinatorics and geometry, e.g., in topological lower bounds for the chromatic number of a graph. In a certain range of dimensions, deciding the embeddability of a simplicial complex into ℝ d also amounts to a ℤ 2-index computation. This is the main motivation of our work. We believe that investigating the computational complexity of questions in homotopy theory and similar areas presents a fascinating research area, and we hope that our work may help bridge the cultural gap between algebraic topology and theoretical computer science.","lang":"eng"}],"publist_id":"4466"},{"extern":1,"abstract":[{"text":"The colored Tverberg theorem asserts that for eve;ry d and r there exists t=t(d,r) such that for every set C ⊂ ℝ d of cardinality (d + 1)t, partitioned into t-point subsets C 1, C 2,...,C d+1 (which we think of as color classes; e. g., the points of C 1 are red, the points of C 2 blue, etc.), there exist r disjoint sets R 1, R 2,...,R r⊆C that are rainbow, meaning that {pipe}R i∩C j{pipe}≤1 for every i,j, and whose convex hulls all have a common point. All known proofs of this theorem are topological. We present a geometric version of a recent beautiful proof by Blagojević, Matschke, and Ziegler, avoiding a direct use of topological methods. The purpose of this de-topologization is to make the proof more concrete and intuitive, and accessible to a wider audience.","lang":"eng"}],"publist_id":"4468","issue":"2","type":"journal_article","date_created":"2018-12-11T11:57:39Z","date_updated":"2021-01-12T06:57:29Z","volume":47,"author":[{"last_name":"Matoušek","first_name":"Jiří","full_name":"Matoušek, Jiří"},{"id":"38AC689C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1191-6714","first_name":"Martin","last_name":"Tancer","full_name":"Martin Tancer"},{"last_name":"Wagner","first_name":"Uli","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Uli Wagner"}],"status":"public","title":"A geometric proof of the colored Tverberg theorem","publication_status":"published","publisher":"Springer","intvolume":" 47","year":"2012","_id":"2438","acknowledgement":"We would like to thank Marek Krcál for useful discussions at initial stages of this research. We also thank Günter M. Ziegler for valuable comments, and Peter Landweber and two anonymous referees for detailed comments and corrections that greatly helped to improve the presentation. In particular, we are indebted to one of the referees for pointing out to us reference [19]. M. Tancer is supported by the grants SVV-2010-261313 (Discrete Methods and Algorithms) and GAUK 49209. U. Wagner’s research is supported by the Swiss National Science Foundation (SNF Projects 200021- 125309 and 200020-125027). ","day":"01","month":"03","date_published":"2012-03-01T00:00:00Z","doi":"10.1007/s00454-011-9368-2","quality_controlled":0,"page":"245 - 265","publication":"Discrete & Computational Geometry","citation":{"chicago":"Matoušek, Jiří, Martin Tancer, and Uli Wagner. “A Geometric Proof of the Colored Tverberg Theorem.” Discrete & Computational Geometry. Springer, 2012. https://doi.org/10.1007/s00454-011-9368-2.","mla":"Matoušek, Jiří, et al. “A Geometric Proof of the Colored Tverberg Theorem.” Discrete & Computational Geometry, vol. 47, no. 2, Springer, 2012, pp. 245–65, doi:10.1007/s00454-011-9368-2.","short":"J. Matoušek, M. Tancer, U. Wagner, Discrete & Computational Geometry 47 (2012) 245–265.","ista":"Matoušek J, Tancer M, Wagner U. 2012. A geometric proof of the colored Tverberg theorem. Discrete & Computational Geometry. 47(2), 245–265.","ieee":"J. Matoušek, M. Tancer, and U. Wagner, “A geometric proof of the colored Tverberg theorem,” Discrete & Computational Geometry, vol. 47, no. 2. Springer, pp. 245–265, 2012.","apa":"Matoušek, J., Tancer, M., & Wagner, U. (2012). A geometric proof of the colored Tverberg theorem. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-011-9368-2","ama":"Matoušek J, Tancer M, Wagner U. A geometric proof of the colored Tverberg theorem. Discrete & Computational Geometry. 2012;47(2):245-265. doi:10.1007/s00454-011-9368-2"}},{"publication":"International Journal of Number Theory","oa":1,"citation":{"ieee":"T. D. Browning and A. Haynes, “Incomplete kloosterman sums and multiplicative inverses in short intervals,” International Journal of Number Theory, vol. 9, no. 2. World Scientific Publishing, pp. 481–486, 2012.","apa":"Browning, T. D., & Haynes, A. (2012). Incomplete kloosterman sums and multiplicative inverses in short intervals. International Journal of Number Theory. World Scientific Publishing. https://doi.org/ https://doi.org/10.1142/S1793042112501448","ista":"Browning TD, Haynes A. 2012. Incomplete kloosterman sums and multiplicative inverses in short intervals. International Journal of Number Theory. 9(2), 481–486.","ama":"Browning TD, Haynes A. Incomplete kloosterman sums and multiplicative inverses in short intervals. International Journal of Number Theory. 2012;9(2):481-486. doi: https://doi.org/10.1142/S1793042112501448","chicago":"Browning, Timothy D, and Alan Haynes. “Incomplete Kloosterman Sums and Multiplicative Inverses in Short Intervals.” International Journal of Number Theory. World Scientific Publishing, 2012. https://doi.org/ https://doi.org/10.1142/S1793042112501448.","short":"T.D. Browning, A. Haynes, International Journal of Number Theory 9 (2012) 481–486.","mla":"Browning, Timothy D., and Alan Haynes. “Incomplete Kloosterman Sums and Multiplicative Inverses in Short Intervals.” International Journal of Number Theory, vol. 9, no. 2, World Scientific Publishing, 2012, pp. 481–86, doi: https://doi.org/10.1142/S1793042112501448."},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1204.6374"}],"quality_controlled":0,"page":"481 - 486","doi":" https://doi.org/10.1142/S1793042112501448","date_published":"2012-11-30T00:00:00Z","day":"30","month":"11","_id":"244","acknowledgement":"EP/E053262/1\tEngineering and Physical Sciences Research Council\tEPSRC,\nEP/J00149X/1\tEngineering and Physical Sciences Research Council\tEPSRC\t","year":"2012","publication_status":"published","title":"Incomplete kloosterman sums and multiplicative inverses in short intervals","status":"public","publisher":"World Scientific Publishing","intvolume":" 9","author":[{"first_name":"Timothy D","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","full_name":"Timothy Browning"},{"full_name":"Haynes, Alan K","first_name":"Alan","last_name":"Haynes"}],"date_updated":"2021-01-12T06:57:30Z","date_created":"2018-12-11T11:45:24Z","volume":9,"type":"journal_article","abstract":[{"text":"We investigate the solubility of the congruence xy ≡ 1 (mod p), where p is a prime and x, y are restricted to lie in suitable short intervals. Our work relies on a mean value theorem for incomplete Kloosterman sums.","lang":"eng"}],"issue":"2","publist_id":"7660","extern":1},{"citation":{"ama":"Chen D, Morin P, Wagner U. Absolute approximation of Tukey depth: Theory and experiments. Computational Geometry: Theory and Applications. 2012;46(5):566-573. doi:10.1016/j.comgeo.2012.03.001","ieee":"D. Chen, P. Morin, and U. Wagner, “Absolute approximation of Tukey depth: Theory and experiments,” Computational Geometry: Theory and Applications, vol. 46, no. 5. Elsevier, pp. 566–573, 2012.","apa":"Chen, D., Morin, P., & Wagner, U. (2012). Absolute approximation of Tukey depth: Theory and experiments. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/j.comgeo.2012.03.001","ista":"Chen D, Morin P, Wagner U. 2012. Absolute approximation of Tukey depth: Theory and experiments. Computational Geometry: Theory and Applications. 46(5), 566–573.","short":"D. Chen, P. Morin, U. Wagner, Computational Geometry: Theory and Applications 46 (2012) 566–573.","mla":"Chen, Dan, et al. “Absolute Approximation of Tukey Depth: Theory and Experiments.” Computational Geometry: Theory and Applications, vol. 46, no. 5, Elsevier, 2012, pp. 566–73, doi:10.1016/j.comgeo.2012.03.001.","chicago":"Chen, Dan, Pat Morin, and Uli Wagner. “Absolute Approximation of Tukey Depth: Theory and Experiments.” Computational Geometry: Theory and Applications. Elsevier, 2012. https://doi.org/10.1016/j.comgeo.2012.03.001."},"publication":"Computational Geometry: Theory and Applications","page":"566 - 573","quality_controlled":0,"date_published":"2012-07-01T00:00:00Z","doi":"10.1016/j.comgeo.2012.03.001","month":"07","day":"01","_id":"2439","year":"2012","publisher":"Elsevier","intvolume":" 46","title":"Absolute approximation of Tukey depth: Theory and experiments","status":"public","publication_status":"published","author":[{"full_name":"Chen, Dan","first_name":"Dan","last_name":"Chen"},{"first_name":"Pat","last_name":"Morin","full_name":"Morin, Pat"},{"full_name":"Uli Wagner","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","first_name":"Uli"}],"volume":46,"date_created":"2018-12-11T11:57:40Z","date_updated":"2021-01-12T06:57:29Z","type":"journal_article","issue":"5","publist_id":"4467","abstract":[{"text":"A Monte Carlo approximation algorithm for the Tukey depth problem in high dimensions is introduced. The algorithm is a generalization of an algorithm presented by Rousseeuw and Struyf (1998) . The performance of this algorithm is studied both analytically and experimentally.","lang":"eng"}],"extern":1},{"type":"conference","extern":1,"publist_id":"4464","abstract":[{"text":"Eigenvalues associated to graphs are a well-studied subject. In particular the spectra of the adjacency matrix and of the Laplacian of random graphs G(n, p) are known quite precisely. We consider generalizations of these matrices to simplicial complexes of higher dimensions and study their eigenvalues for the Linial-Meshulam model X k(n, p) of random k-dimensional simplicial complexes on n vertices. We show that for p = Ω(log n/n), the eigenvalues of both, the higher-dimensional adjacency matrix and the Laplacian, are a.a.s. sharply concentrated around two values. In a second part of the paper, we discuss a possible higherdimensional analogue of the Discrete Cheeger Inequality. This fundamental inequality expresses a close relationship between the eigenvalues of a graph and its combinatorial expansion properties; in particular, spectral expansion (a large eigenvalue gap) implies edge expansion. Recently, a higher-dimensional analogue of edge expansion for simplicial complexes was introduced by Gromov, and independently by Linial, Meshulam and Wallach and by Newman and Rabinovich. It is natural to ask whether there is a higher-dimensional version of Cheeger's inequality. We show that the most straightforward version of a higher-dimensional Cheeger inequality fails: for every k > 1, there is an infinite family of k-dimensional complexes that are spectrally expanding (there is a large eigenvalue gap for the Laplacian) but not combinatorially expanding.","lang":"eng"}],"publisher":"ACM","status":"public","title":"On Laplacians of random complexes","publication_status":"published","_id":"2441","year":"2012","date_created":"2018-12-11T11:57:41Z","date_updated":"2021-01-12T06:57:30Z","author":[{"full_name":"Gundert, Anna","first_name":"Anna","last_name":"Gundert"},{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1494-0568","first_name":"Uli","last_name":"Wagner","full_name":"Uli Wagner"}],"month":"06","day":"01","page":"151 - 160","quality_controlled":0,"citation":{"ieee":"A. Gundert and U. Wagner, “On Laplacians of random complexes,” presented at the SGC: Symposuim on Computational Geometry, 2012, pp. 151–160.","apa":"Gundert, A., & Wagner, U. (2012). On Laplacians of random complexes (pp. 151–160). Presented at the SGC: Symposuim on Computational Geometry, ACM. https://doi.org/10.1145/2261250.2261272","ista":"Gundert A, Wagner U. 2012. On Laplacians of random complexes. SGC: Symposuim on Computational Geometry, 151–160.","ama":"Gundert A, Wagner U. On Laplacians of random complexes. In: ACM; 2012:151-160. doi:10.1145/2261250.2261272","chicago":"Gundert, Anna, and Uli Wagner. “On Laplacians of Random Complexes,” 151–60. ACM, 2012. https://doi.org/10.1145/2261250.2261272.","short":"A. Gundert, U. Wagner, in:, ACM, 2012, pp. 151–160.","mla":"Gundert, Anna, and Uli Wagner. On Laplacians of Random Complexes. ACM, 2012, pp. 151–60, doi:10.1145/2261250.2261272."},"date_published":"2012-06-01T00:00:00Z","doi":"10.1145/2261250.2261272","conference":{"name":"SGC: Symposuim on Computational Geometry"}},{"doi":"10.1105/tpc.112.098152","date_published":"2012-07-01T00:00:00Z","citation":{"apa":"Feraru, E., Feraru, M., Asaoka, R., Paciorek, T., De Rycke, R., Tanaka, H., … Friml, J. (2012). BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. Plant Cell. American Society of Plant Biologists. https://doi.org/10.1105/tpc.112.098152","ieee":"E. Feraru et al., “BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis,” Plant Cell, vol. 24, no. 7. American Society of Plant Biologists, pp. 3074–3086, 2012.","ista":"Feraru E, Feraru M, Asaoka R, Paciorek T, De Rycke R, Tanaka H, Nakano A, Friml J. 2012. BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. Plant Cell. 24(7), 3074–3086.","ama":"Feraru E, Feraru M, Asaoka R, et al. BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis. Plant Cell. 2012;24(7):3074-3086. doi:10.1105/tpc.112.098152","chicago":"Feraru, Elena, Mugurel Feraru, Rin Asaoka, Tomasz Paciorek, Riet De Rycke, Hirokazu Tanaka, Akihiko Nakano, and Jiří Friml. “BEX5/RabA1b Regulates Trans-Golgi Network-to-Plasma Membrane Protein Trafficking in Arabidopsis.” Plant Cell. American Society of Plant Biologists, 2012. https://doi.org/10.1105/tpc.112.098152.","short":"E. Feraru, M. Feraru, R. Asaoka, T. Paciorek, R. De Rycke, H. Tanaka, A. Nakano, J. Friml, Plant Cell 24 (2012) 3074–3086.","mla":"Feraru, Elena, et al. “BEX5/RabA1b Regulates Trans-Golgi Network-to-Plasma Membrane Protein Trafficking in Arabidopsis.” Plant Cell, vol. 24, no. 7, American Society of Plant Biologists, 2012, pp. 3074–86, doi:10.1105/tpc.112.098152."},"publication":"Plant Cell","page":"3074 - 3086","quality_controlled":0,"day":"01","month":"07","author":[{"full_name":"Feraru, Elena","last_name":"Feraru","first_name":"Elena"},{"full_name":"Feraru, Mugurel Ioan","last_name":"Feraru","first_name":"Mugurel"},{"first_name":"Rin","last_name":"Asaoka","full_name":"Asaoka, Rin"},{"full_name":"Paciorek, Tomasz","first_name":"Tomasz","last_name":"Paciorek"},{"first_name":"Riet","last_name":"De Rycke","full_name":"De Rycke, Riet M"},{"full_name":"Tanaka, Hirokazu","first_name":"Hirokazu","last_name":"Tanaka"},{"full_name":"Nakano, Akihiko","last_name":"Nakano","first_name":"Akihiko"},{"full_name":"Jirí Friml","last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"volume":24,"date_created":"2018-12-11T11:57:45Z","date_updated":"2021-01-12T06:57:35Z","year":"2012","_id":"2453","intvolume":" 24","publisher":"American Society of Plant Biologists","publication_status":"published","status":"public","title":"BEX5/RabA1b regulates trans-Golgi network-to-plasma membrane protein trafficking in Arabidopsis","issue":"7","publist_id":"4450","abstract":[{"text":"Constitutive endocytic recycling is a crucial mechanism allowing regulation of the activity of proteins at the plasma membrane and for rapid changes in their localization, as demonstrated in plants for PIN-FORMED (PIN) proteins, the auxin transporters. To identify novel molecular components of endocytic recycling, mainly exocytosis, we designed a PIN1-green fluorescent protein fluorescence imaging-based forward genetic screen for Arabidopsis thaliana mutants that showed increased intracellular accumulation of cargos in response to the trafficking inhibitor brefeldin A (BFA). We identified bex5 (for BFA-visualized exocytic trafficking defective), a novel dominant mutant carrying a missense mutation that disrupts a conserved sequence motif of the small GTPase, RAS GENES FROM RAT BRAINA1b. bex5 displays defects such as enhanced protein accumulation in abnormal BFA compartments, aberrant endosomes, and defective exocytosis and transcytosis. BEX5/RabA1b localizes to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking processes like those regulated by GTP exchange factors on ADP-ribosylation factors GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1, which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. All together, this study identifies Arabidopsis BEX5/RabA1b as a novel regulator of protein trafficking from a TGN/EE compartment to the plasma membrane.","lang":"eng"}],"extern":1,"type":"journal_article"},{"day":"15","month":"10","quality_controlled":"1","page":"3677 - 3682","publication":"Development","citation":{"chicago":"Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on Stairways in Matera.” Development. Company of Biologists, 2012. https://doi.org/10.1242/dev.080861.","mla":"Beeckman, Tom, and Jiří Friml. “Plant Developmental Biologists Meet on Stairways in Matera.” Development, vol. 139, no. 20, Company of Biologists, 2012, pp. 3677–82, doi:10.1242/dev.080861.","short":"T. Beeckman, J. Friml, Development 139 (2012) 3677–3682.","ista":"Beeckman T, Friml J. 2012. Plant developmental biologists meet on stairways in Matera. Development. 139(20), 3677–3682.","apa":"Beeckman, T., & Friml, J. (2012). Plant developmental biologists meet on stairways in Matera. Development. Company of Biologists. https://doi.org/10.1242/dev.080861","ieee":"T. Beeckman and J. Friml, “Plant developmental biologists meet on stairways in Matera,” Development, vol. 139, no. 20. Company of Biologists, pp. 3677–3682, 2012.","ama":"Beeckman T, Friml J. Plant developmental biologists meet on stairways in Matera. Development. 2012;139(20):3677-3682. doi:10.1242/dev.080861"},"language":[{"iso":"eng"}],"date_published":"2012-10-15T00:00:00Z","doi":"10.1242/dev.080861","type":"journal_article","extern":"1","abstract":[{"text":"The third EMBO Conference on Plant Molecular Biology, which focused on ‘Plant development and environmental interactions’,was held in May 2012 in Matera, Italy. Here, we review some of the topics and themes that emerged from the various contributions; namely, steering technologies, transcriptional networks and hormonal regulation, small RNAs, cell and tissue polarity, environmental control and natural variation. We intend to provide the reader who might have missed this remarkable event with a glimpse of the recent progress made in this blossoming research field.","lang":"eng"}],"issue":"20","publist_id":"4447","status":"public","publication_status":"published","title":"Plant developmental biologists meet on stairways in Matera","intvolume":" 139","publisher":"Company of Biologists","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"2456","year":"2012","date_created":"2018-12-11T11:57:46Z","date_updated":"2021-01-12T06:57:35Z","oa_version":"None","volume":139,"author":[{"last_name":"Beeckman","first_name":"Tom","full_name":"Beeckman, Tom"},{"full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}]},{"month":"05","doi":"10.3389/fpls.2012.00097","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"oa":1,"quality_controlled":"1","file_date_updated":"2020-07-14T12:45:41Z","publist_id":"4444","license":"https://creativecommons.org/licenses/by-nc/4.0/","extern":"1","article_number":"97","author":[{"last_name":"Zwiewka","first_name":"Marta","full_name":"Zwiewka, Marta"},{"last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí"}],"date_updated":"2021-01-12T06:57:36Z","date_created":"2018-12-11T11:57:47Z","volume":3,"year":"2012","publication_status":"published","publisher":"Frontiers Research Foundation","day":"24","has_accepted_license":"1","date_published":"2012-05-24T00:00:00Z","publication":"Frontiers in Plant Science","citation":{"chicago":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” Frontiers in Plant Science. Frontiers Research Foundation, 2012. https://doi.org/10.3389/fpls.2012.00097.","short":"M. Zwiewka, J. Friml, Frontiers in Plant Science 3 (2012).","mla":"Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic Screens to Identify Trafficking Regulators in Plants.” Frontiers in Plant Science, vol. 3, no. May, 97, Frontiers Research Foundation, 2012, doi:10.3389/fpls.2012.00097.","ieee":"M. Zwiewka and J. Friml, “Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants,” Frontiers in Plant Science, vol. 3, no. May. Frontiers Research Foundation, 2012.","apa":"Zwiewka, M., & Friml, J. (2012). Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. Frontiers in Plant Science. Frontiers Research Foundation. https://doi.org/10.3389/fpls.2012.00097","ista":"Zwiewka M, Friml J. 2012. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. Frontiers in Plant Science. 3(May), 97.","ama":"Zwiewka M, Friml J. Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants. Frontiers in Plant Science. 2012;3(May). doi:10.3389/fpls.2012.00097"},"abstract":[{"text":"Coordinated, subcellular trafficking of proteins is one of the fundamental properties of the multicellular eukaryotic organisms. Trafficking involves a large diversity of compartments, pathways, cargo molecules, and vesicle-sorting events. It is also crucial in regulating the localization and, thus, the activity of various proteins, but the process is still poorly genetically defined in plants. In the past, forward genetics screens had been used to determine the function of genes by searching for a specific morphological phenotype in the organism population in which mutations had been induced chemically or by irradiation. Unfortunately, these straightforward genetic screens turned out to be limited in identifying new regulators of intracellular protein transport, because mutations affecting essential trafficking pathways often lead to lethality. In addition, the use of these approaches has been restricted by functional redundancy among trafficking regulators. Screens for mutants that rely on the observation of changes in the cellular localization or dynamics of fluorescent subcellular markers enable, at least partially, to circumvent these issues. Hence, such image-based screens provide the possibility to identify either alleles with weak effects or components of the subcellular trafficking machinery that have no strong impact on the plant growth.","lang":"eng"}],"issue":"May","type":"journal_article","file":[{"access_level":"open_access","file_name":"2012_frontiers_Zwiewka.pdf","content_type":"application/pdf","file_size":1468230,"creator":"kschuh","relation":"main_file","file_id":"6346","checksum":"ab4e9487ccdb83a7a0a9ee6811521844","date_created":"2019-04-26T06:49:26Z","date_updated":"2020-07-14T12:45:41Z"}],"oa_version":"Published Version","_id":"2459","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","title":"Fluorescence imaging-based forward genetic screens to identify trafficking regulators in plants","status":"public","ddc":["580"],"intvolume":" 3"},{"month":"08","day":"21","quality_controlled":"1","page":"R635 - R637","publication":"Current Biology","citation":{"mla":"Li, Hongjiang, et al. “Cell Polarity: Stretching Prevents Developmental Cramps.” Current Biology, vol. 22, no. 16, Cell Press, 2012, pp. R635–37, doi:10.1016/j.cub.2012.06.053.","short":"H. Li, J. Friml, W. Grunewald, Current Biology 22 (2012) R635–R637.","chicago":"Li, Hongjiang, Jiří Friml, and Wim Grunewald. “Cell Polarity: Stretching Prevents Developmental Cramps.” Current Biology. Cell Press, 2012. https://doi.org/10.1016/j.cub.2012.06.053.","ama":"Li H, Friml J, Grunewald W. Cell polarity: Stretching prevents developmental cramps. Current Biology. 2012;22(16):R635-R637. doi:10.1016/j.cub.2012.06.053","ista":"Li H, Friml J, Grunewald W. 2012. Cell polarity: Stretching prevents developmental cramps. Current Biology. 22(16), R635–R637.","apa":"Li, H., Friml, J., & Grunewald, W. (2012). Cell polarity: Stretching prevents developmental cramps. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2012.06.053","ieee":"H. Li, J. Friml, and W. Grunewald, “Cell polarity: Stretching prevents developmental cramps,” Current Biology, vol. 22, no. 16. Cell Press, pp. R635–R637, 2012."},"language":[{"iso":"eng"}],"doi":"10.1016/j.cub.2012.06.053","date_published":"2012-08-21T00:00:00Z","type":"journal_article","extern":"1","abstract":[{"lang":"eng","text":"Initiation and successive development of organs induce mechanical stresses at the cellular level. Using the tomato shoot apex, a new study now proposes that mechanical strain regulates the plasma membrane abundance of the PIN1 auxin transporter, thereby reinforcing a positive feed-back loop between growth and auxin accumulation."}],"publist_id":"4445","issue":"16","publication_status":"published","title":"Cell polarity: Stretching prevents developmental cramps","status":"public","publisher":"Cell Press","intvolume":" 22","_id":"2458","year":"2012","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_created":"2018-12-11T11:57:47Z","date_updated":"2021-01-12T06:57:36Z","volume":22,"oa_version":"None","author":[{"full_name":"Li, Hongjiang","first_name":"Hongjiang","last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5039-9660"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jirí","last_name":"Friml","full_name":"Friml, Jirí"},{"full_name":"Grunewald, Wim","last_name":"Grunewald","first_name":"Wim"}]},{"publisher":"Wiley-Blackwell","intvolume":" 590","title":"Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells","status":"public","publication_status":"published","year":"2012","_id":"2476","volume":590,"date_created":"2018-12-11T11:57:53Z","date_updated":"2021-01-12T06:57:43Z","author":[{"full_name":"Sümegi, Máté","first_name":"Máté","last_name":"Sümegi"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"},{"full_name":"Lörincz, Andrea","last_name":"Lörincz","first_name":"Andrea"},{"full_name":"Eyre, Mark D","last_name":"Eyre","first_name":"Mark"},{"full_name":"Nusser, Zoltán","last_name":"Nusser","first_name":"Zoltán"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto"}],"type":"journal_article","extern":1,"issue":"7","publist_id":"4425","abstract":[{"text":"Recently developed pharmacogenetic and optogenetic approaches, with their own advantages and disadvantages, have become indispensable tools in modern neuroscience. Here, we employed a previously described knock-in mouse line (GABA ARγ2 77Ilox) in which the γ2 subunit of the GABA A receptor (GABA AR) was mutated to become zolpidem insensitive (γ2 77I) and used viral vectors to swap γ2 77I with wild-type, zolpidem-sensitive γ2 subunits (γ2 77F). The verification of unaltered density and subcellular distribution of the virally introduced γ2 subunits requires their selective labelling. For this we generated six N- and six C-terminal-tagged γ2 subunits, with which cortical cultures of GABA ARγ2 -/- mice were transduced using lentiviruses. We found that the N-terminal AU1 tag resulted in excellent immunodetection and unimpaired synaptic localization. Unaltered kinetic properties of the AU1-tagged γ2 ( AU1γ2 77F) channels were demonstrated with whole-cell patch-clamp recordings of spontaneous IPSCs from cultured cells. Next, we carried out stereotaxic injections of lenti- and adeno-associated viruses containing Cre-recombinase and the AU1γ2 77F subunit (Cre-2A- AU1γ2 77F) into the neocortex of GABA ARγ2 77Ilox mice. Light microscopic immunofluorescence and electron microscopic freeze-fracture replica immunogold labelling demonstrated the efficient immunodetection of the AU1 tag and the normal enrichment of the AU1γ2 77F subunits in perisomatic GABAergic synapses. In line with this, miniature and action potential-evoked IPSCs whole-cell recorded from transduced cells had unaltered amplitudes, kinetics and restored zolpidem sensitivity. Our results obtained with a wide range of structural and functional verification methods reveal unaltered subcellular distributions and functional properties of γ2 77I and AU1γ2 77F GABA ARs in cortical pyramidal cells. This transgenic-viral pharmacogenetic approach has the advantage that it does not require any extrinsic protein that might endow some unforeseen alterations of the genetically modified cells. In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations.","lang":"eng"}],"page":"1517 - 1534","quality_controlled":0,"citation":{"short":"M. Sümegi, Y. Fukazawa, K. Matsui, A. Lörincz, M. Eyre, Z. Nusser, R. Shigemoto, Journal of Physiology 590 (2012) 1517–1534.","mla":"Sümegi, Máté, et al. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” Journal of Physiology, vol. 590, no. 7, Wiley-Blackwell, 2012, pp. 1517–34, doi:10.1113/jphysiol.2012.227538.","chicago":"Sümegi, Máté, Yugo Fukazawa, Ko Matsui, Andrea Lörincz, Mark Eyre, Zoltán Nusser, and Ryuichi Shigemoto. “Virus-Mediated Swapping of Zolpidem-Insensitive with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” Journal of Physiology. Wiley-Blackwell, 2012. https://doi.org/10.1113/jphysiol.2012.227538.","ama":"Sümegi M, Fukazawa Y, Matsui K, et al. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal of Physiology. 2012;590(7):1517-1534. doi:10.1113/jphysiol.2012.227538","ieee":"M. Sümegi et al., “Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells,” Journal of Physiology, vol. 590, no. 7. Wiley-Blackwell, pp. 1517–1534, 2012.","apa":"Sümegi, M., Fukazawa, Y., Matsui, K., Lörincz, A., Eyre, M., Nusser, Z., & Shigemoto, R. (2012). Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2012.227538","ista":"Sümegi M, Fukazawa Y, Matsui K, Lörincz A, Eyre M, Nusser Z, Shigemoto R. 2012. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. Journal of Physiology. 590(7), 1517–1534."},"publication":"Journal of Physiology","doi":"10.1113/jphysiol.2012.227538","date_published":"2012-04-07T00:00:00Z","month":"04","day":"07"},{"publication":"Molecular Neurodegeneration","citation":{"short":"Y. Saito, T. Inoue, G. Zhu, N. Kimura, M. Okada, M. Nishimura, S. Murayama, S. Kaneko, R. Shigemoto, K. Imoto, T. Suzuki, Molecular Neurodegeneration 7 (2012).","mla":"Saito, Yuhki, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” Molecular Neurodegeneration, vol. 7, no. 1, BioMed Central, 2012, doi:10.1186/1750-1326-7-50.","chicago":"Saito, Yuhki, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Shigeo Murayama, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation in Alzheimer’s Disease.” Molecular Neurodegeneration. BioMed Central, 2012. https://doi.org/10.1186/1750-1326-7-50.","ama":"Saito Y, Inoue T, Zhu G, et al. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. Molecular Neurodegeneration. 2012;7(1). doi:10.1186/1750-1326-7-50","apa":"Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., … Suzuki, T. (2012). Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. Molecular Neurodegeneration. BioMed Central. https://doi.org/10.1186/1750-1326-7-50","ieee":"Y. Saito et al., “Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease,” Molecular Neurodegeneration, vol. 7, no. 1. BioMed Central, 2012.","ista":"Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Murayama S, Kaneko S, Shigemoto R, Imoto K, Suzuki T. 2012. Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease. Molecular Neurodegeneration. 7(1)."},"quality_controlled":0,"doi":"10.1186/1750-1326-7-50","date_published":"2012-10-03T00:00:00Z","month":"10","day":"03","year":"2012","_id":"2475","status":"public","publication_status":"published","title":"Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease","publisher":"BioMed Central","intvolume":" 7","author":[{"full_name":"Saito, Yuhki","first_name":"Yuhki","last_name":"Saito"},{"first_name":"Tsuyoshi","last_name":"Inoue","full_name":"Inoue, Tsuyoshi"},{"full_name":"Zhu, Gang","first_name":"Gang","last_name":"Zhu"},{"full_name":"Kimura, Naoki","last_name":"Kimura","first_name":"Naoki"},{"first_name":"Motohiro","last_name":"Okada","full_name":"Okada, Motohiro"},{"full_name":"Nishimura, Masaki","first_name":"Masaki","last_name":"Nishimura"},{"first_name":"Shigeo","last_name":"Murayama","full_name":"Murayama, Shigeo"},{"full_name":"Kaneko, Sunao","last_name":"Kaneko","first_name":"Sunao"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto"},{"last_name":"Imoto","first_name":"Keiji","full_name":"Imoto, Keiji"},{"last_name":"Suzuki","first_name":"Toshiharu","full_name":"Suzuki, Toshiharu"}],"date_updated":"2021-01-12T06:57:42Z","date_created":"2018-12-11T11:57:53Z","volume":7,"type":"journal_article","abstract":[{"text":"Background: One of the best-characterized causative factors of Alzheimer's disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itself enhances Aβ generation. However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear. Results: X11 and X11-like (X11L) gene knockout mice suffered from epileptic seizures, along with a malfunction of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Genetic ablation of HCN1 in mice and HCN1 channel blockage in cultured Neuro2a (N2a) cells enhanced Aβ generation. Interestingly, HCN1 levels dramatically decreased in the temporal lobe of cynomolgus monkeys (Macaca fascicularis) during aging and were significantly diminished in the temporal lobe of sporadic AD patients. Conclusion: Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution along with epilepsy. Moreover, the reduction in HCN1 levels in aged primates may contribute to augmented Aβ generation. Taken together, HCN1 is proposed to play an important role in the molecular linkage between epileptic seizures and Aβ generation, and in the aggravation of sporadic AD.","lang":"eng"}],"issue":"1","publist_id":"4426","extern":1},{"status":"public","title":"Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation","publication_status":"published","publisher":"National Academy of Sciences","intvolume":" 109","year":"2012","_id":"2477","date_created":"2018-12-11T11:57:54Z","date_updated":"2021-01-12T06:57:43Z","volume":109,"author":[{"first_name":"Takuya","last_name":"Sasaki","full_name":"Sasaki, Takuya"},{"first_name":"Kaoru","last_name":"Beppu","full_name":"Beppu, Kaoru"},{"last_name":"Tanaka","first_name":"Kenji","full_name":"Tanaka, Kenji F"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"}],"type":"journal_article","extern":1,"abstract":[{"text":"Dynamic activity of glia has repeatedly been demonstrated, but if such activity is independent from neuronal activity, glia would not have any role in the information processing in the brain or in the generation of animal behavior. Evidence for neurons communicating with glia is solid, but the signaling pathway leading back from glial-to-neuronal activity was often difficult to study. Here, we introduced a transgenic mouse line in which channelrhodopsin-2, a light-gated cation channel, was expressed in astrocytes. Selective photostimulation of these astrocytes in vivo triggered neuronal activation. Using slice preparations, we show that glial photostimulation leads to release of glutamate, which was sufficient to activate AMPA receptors on Purkinje cells and to induce long-term depression of parallel fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors. In contrast to neuronal synaptic vesicular release, glial activation likely causes preferential activation of extrasynaptic receptors that appose glial membrane. Finally, we show that neuronal activation by glial stimulation can lead to perturbation of cerebellar modulated motor behavior. These findings demonstrate that glia can modulate the tone of neuronal activity and behavior. This animal model is expected to be a potentially powerful approach to study the role of glia in brain function.","lang":"eng"}],"publist_id":"4424","issue":"50","quality_controlled":0,"page":"20720 - 20725","publication":"PNAS","citation":{"mla":"Sasaki, Takuya, et al. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” PNAS, vol. 109, no. 50, National Academy of Sciences, 2012, pp. 20720–25, doi:10.1073/pnas.1213458109.","short":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui, PNAS 109 (2012) 20720–20725.","chicago":"Sasaki, Takuya, Kaoru Beppu, Kenji Tanaka, Yugo Fukazawa, Ryuichi Shigemoto, and Ko Matsui. “Application of an Optogenetic Byway for Perturbing Neuronal Activity via Glial Photostimulation.” PNAS. National Academy of Sciences, 2012. https://doi.org/10.1073/pnas.1213458109.","ama":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. PNAS. 2012;109(50):20720-20725. doi:10.1073/pnas.1213458109","ista":"Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. 2012. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. PNAS. 109(50), 20720–20725.","ieee":"T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui, “Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation,” PNAS, vol. 109, no. 50. National Academy of Sciences, pp. 20720–20725, 2012.","apa":"Sasaki, T., Beppu, K., Tanaka, K., Fukazawa, Y., Shigemoto, R., & Matsui, K. (2012). Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1213458109"},"doi":"10.1073/pnas.1213458109","date_published":"2012-12-11T00:00:00Z","month":"12","day":"11"},{"author":[{"last_name":"Abrahamsson","first_name":"Therese","full_name":"Abrahamsson, Therese"},{"last_name":"Cathala","first_name":"Laurence","full_name":"Cathala, Laurence"},{"full_name":"Matsui, Ko","last_name":"Matsui","first_name":"Ko"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"full_name":"DiGregorio, David A","first_name":"David","last_name":"Digregorio"}],"date_updated":"2021-01-12T06:57:42Z","date_created":"2018-12-11T11:57:52Z","volume":73,"year":"2012","_id":"2474","status":"public","publication_status":"published","title":"Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity","publisher":"Elsevier","intvolume":" 73","abstract":[{"text":"Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar stellate cells by combining two-photon guided electrical stimulation, glutamate uncaging, electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites produced somatic responses that became smaller and slower with increasing distance from the soma, sublinear subthreshold input-output relationships, and a somatodendritic gradient of short-term plasticity. Unlike most studies showing that neurons employ active dendritic mechanisms, we found that passive cable properties of thin dendrites determine the sublinear integration and plasticity gradient, which both result from large dendritic depolarizations that reduce synaptic driving force. These integrative properties allow stellate cells to act as spatiotemporal filters of synaptic input patterns, thereby biasing their output in favor of sparse presynaptic activity. Stellate cells are critical sources of inhibition in the cerebellum, but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson et al. show that thin dendrites and passive membrane properties of SCs promote sublinear synaptic summation and distance-dependent short-term plasticity. ","lang":"eng"}],"publist_id":"4427","issue":"6","extern":1,"type":"journal_article","date_published":"2012-03-22T00:00:00Z","doi":"10.1016/j.neuron.2012.01.027","publication":"Neuron","citation":{"apa":"Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., & Digregorio, D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2012.01.027","ieee":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity,” Neuron, vol. 73, no. 6. Elsevier, pp. 1159–1172, 2012.","ista":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.","ama":"Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron. 2012;73(6):1159-1172. doi:10.1016/j.neuron.2012.01.027","chicago":"Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron. Elsevier, 2012. https://doi.org/10.1016/j.neuron.2012.01.027.","short":"T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron 73 (2012) 1159–1172.","mla":"Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron, vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:10.1016/j.neuron.2012.01.027."},"quality_controlled":0,"page":"1159 - 1172","month":"03","day":"22"},{"type":"journal_article","publist_id":"4386","issue":"6","abstract":[{"lang":"eng","text":"We investigated the temporal and spatial expression of SK2 in the developing mouse hippocampus using molecular and biochemical techniques, quantitative immunogold electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed in the developing and adult hippocampus. Western blotting and immunohistochemistry showed that SK2 protein increased with age. This was accompanied by a shift in subcellular localization. Early in development (P5), SK2 was predominantly localized to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic density (PSD) also increased during development. In the adult, SK2 expression on the spine plasma membrane showed a proximal-to-distal gradient. Consistent with this redistribution and gradient of SK2, the selective SK channel blocker apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1 pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs was not different between synapses in proximal or distal stratum radiatum or stratum lacunosum-moleculare in adult. These results show a developmental increase and gradient in SK2-containing channel surface expression that underlie their influence on neurotransmission, and that may contribute to increased memory acquisition during early development."}],"extern":1,"_id":"2515","year":"2012","intvolume":" 22","publisher":"Wiley-Blackwell","publication_status":"published","title":" Developmental profile of SK2 channel expression and function in CA1 neurons","status":"public","author":[{"full_name":"Ballesteros-Merino, Carmen","last_name":"Ballesteros Merino","first_name":"Carmen"},{"full_name":"Lin, Michael","last_name":"Lin","first_name":"Michael"},{"first_name":"Wendy","last_name":"Wu","full_name":"Wu, Wendy W"},{"first_name":"Clotilde","last_name":"Ferrándiz Huertas","full_name":"Ferrándiz-Huertas, Clotilde"},{"last_name":"Cabañero","first_name":"María","full_name":"Cabañero, María José"},{"full_name":"Watanabe, Masahiko","last_name":"Watanabe","first_name":"Masahiko"},{"full_name":"Fukazawa, Yugo","first_name":"Yugo","last_name":"Fukazawa"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto"},{"first_name":"James","last_name":"Maylie","full_name":"Maylie, James G"},{"last_name":"Adelman","first_name":"John","full_name":"Adelman, John P"},{"full_name":"Luján, Rafael","first_name":"Rafael","last_name":"Luján"}],"volume":22,"date_updated":"2021-01-12T06:57:57Z","date_created":"2018-12-11T11:58:07Z","month":"06","day":"01","citation":{"chicago":"Ballesteros Merino, Carmen, Michael Lin, Wendy Wu, Clotilde Ferrándiz Huertas, María Cabañero, Masahiko Watanabe, Yugo Fukazawa, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” Hippocampus. Wiley-Blackwell, 2012. https://doi.org/10.1002/hipo.20986.","short":"C. Ballesteros Merino, M. Lin, W. Wu, C. Ferrándiz Huertas, M. Cabañero, M. Watanabe, Y. Fukazawa, R. Shigemoto, J. Maylie, J. Adelman, R. Luján, Hippocampus 22 (2012) 1467–1480.","mla":"Ballesteros Merino, Carmen, et al. “ Developmental Profile of SK2 Channel Expression and Function in CA1 Neurons.” Hippocampus, vol. 22, no. 6, Wiley-Blackwell, 2012, pp. 1467–80, doi:10.1002/hipo.20986.","ieee":"C. Ballesteros Merino et al., “ Developmental profile of SK2 channel expression and function in CA1 neurons,” Hippocampus, vol. 22, no. 6. Wiley-Blackwell, pp. 1467–1480, 2012.","apa":"Ballesteros Merino, C., Lin, M., Wu, W., Ferrándiz Huertas, C., Cabañero, M., Watanabe, M., … Luján, R. (2012). Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. Wiley-Blackwell. https://doi.org/10.1002/hipo.20986","ista":"Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe M, Fukazawa Y, Shigemoto R, Maylie J, Adelman J, Luján R. 2012. Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 22(6), 1467–1480.","ama":"Ballesteros Merino C, Lin M, Wu W, et al. Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 2012;22(6):1467-1480. doi:10.1002/hipo.20986"},"publication":"Hippocampus","page":"1467 - 1480","quality_controlled":0,"doi":"10.1002/hipo.20986","date_published":"2012-06-01T00:00:00Z"},{"citation":{"short":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, R. Shigemoto, Journal of Neuroscience 32 (2012) 2357–2376.","mla":"Budisantoso, Timotheus, et al. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” Journal of Neuroscience, vol. 32, no. 7, Society for Neuroscience, 2012, pp. 2357–76, doi:10.1523/JNEUROSCI.5243-11.2012.","chicago":"Budisantoso, Timotheus, Ko Matsui, Naomi Kamasawa, Yugo Fukazawa, and Ryuichi Shigemoto. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.” Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.5243-11.2012.","ama":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying signal filtering at a multisynapse contact. Journal of Neuroscience. 2012;32(7):2357-2376. doi:10.1523/JNEUROSCI.5243-11.2012","ieee":"T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, and R. Shigemoto, “Mechanisms underlying signal filtering at a multisynapse contact,” Journal of Neuroscience, vol. 32, no. 7. Society for Neuroscience, pp. 2357–2376, 2012.","apa":"Budisantoso, T., Matsui, K., Kamasawa, N., Fukazawa, Y., & Shigemoto, R. (2012). Mechanisms underlying signal filtering at a multisynapse contact. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.5243-11.2012","ista":"Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. 2012. Mechanisms underlying signal filtering at a multisynapse contact. Journal of Neuroscience. 32(7), 2357–2376."},"publication":"Journal of Neuroscience","page":"2357 - 2376","quality_controlled":0,"date_published":"2012-02-15T00:00:00Z","doi":"10.1523/JNEUROSCI.5243-11.2012","month":"02","day":"15","year":"2012","_id":"2514","publisher":"Society for Neuroscience","intvolume":" 32","publication_status":"published","status":"public","title":"Mechanisms underlying signal filtering at a multisynapse contact","author":[{"full_name":"Budisantoso, Timotheus","last_name":"Budisantoso","first_name":"Timotheus"},{"full_name":"Matsui, Ko","first_name":"Ko","last_name":"Matsui"},{"last_name":"Kamasawa","first_name":"Naomi","full_name":"Kamasawa, Naomi"},{"full_name":"Fukazawa, Yugo","last_name":"Fukazawa","first_name":"Yugo"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"}],"volume":32,"date_created":"2018-12-11T11:58:07Z","date_updated":"2021-01-12T06:57:57Z","type":"journal_article","publist_id":"4387","issue":"7","abstract":[{"lang":"eng","text":"Visual information must be relayed through the lateral geniculate nucleus before it reaches the visual cortex. However, not all spikes created in the retina lead to postsynaptic spikes and properties of the retinogeniculate synapse contribute to this filtering. To understand the mechanisms underlying this filtering process, we conducted electrophysiology to assess the properties of signal transmission in the Long-Evans rat. We also performed SDS-digested freeze-fracture replica labeling to quantify the receptor and transporter distribution, as well as EM reconstruction to describe the 3D structure. To analyze the impact of transmitter diffusion on the activity of the receptors, simulations were integrated. We identified that a large contributor to the filtering is the marked paired-pulse depression at this synapse, which was intensified by the morphological characteristics of the contacts. The broad presynaptic and postsynaptic contact area restricts transmitter diffusion two dimensionally. Additionally, the presence of multiple closely arranged release sites invites intersynaptic spillover, which causes desensitization of AMPA receptors. The presence of AMPA receptors that slowly recover from desensitization along with the high presynaptic release probability and multivesicular release at each synapse also contribute to the depression. These features contrast with many other synapses where spatiotemporal spread of transmitter is limited by rapid transmitter clearance allowing synapses to operate more independently. We propose that the micrometer-order structure can ultimately affect the visual information processing."}],"extern":1},{"doi":"10.1523/JNEUROSCI.1142-12.2012","date_published":"2012-09-26T00:00:00Z","page":"13555 - 13567","quality_controlled":0,"citation":{"chicago":"Parajuli, Laxmi, Chikako Nakajima, Ákos Kulik, Ko Matsui, Toni Schneider, Ryuichi Shigemoto, and Yugo Fukazawa. “Quantitative Regional and Ultra Structural Localization of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.” Journal of Neuroscience. Society for Neuroscience, 2012. https://doi.org/10.1523/JNEUROSCI.1142-12.2012.","mla":"Parajuli, Laxmi, et al. “Quantitative Regional and Ultra Structural Localization of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.” Journal of Neuroscience, vol. 32, no. 39, Society for Neuroscience, 2012, pp. 13555–67, doi:10.1523/JNEUROSCI.1142-12.2012.","short":"L. Parajuli, C. Nakajima, Á. Kulik, K. Matsui, T. Schneider, R. Shigemoto, Y. Fukazawa, Journal of Neuroscience 32 (2012) 13555–13567.","ista":"Parajuli L, Nakajima C, Kulik Á, Matsui K, Schneider T, Shigemoto R, Fukazawa Y. 2012. Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. Journal of Neuroscience. 32(39), 13555–13567.","apa":"Parajuli, L., Nakajima, C., Kulik, Á., Matsui, K., Schneider, T., Shigemoto, R., & Fukazawa, Y. (2012). Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1142-12.2012","ieee":"L. Parajuli et al., “Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain,” Journal of Neuroscience, vol. 32, no. 39. Society for Neuroscience, pp. 13555–13567, 2012.","ama":"Parajuli L, Nakajima C, Kulik Á, et al. Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain. Journal of Neuroscience. 2012;32(39):13555-13567. doi:10.1523/JNEUROSCI.1142-12.2012"},"publication":"Journal of Neuroscience","day":"26","month":"09","volume":32,"date_updated":"2021-01-12T06:59:04Z","date_created":"2018-12-11T11:59:05Z","author":[{"first_name":"Laxmi","last_name":"Parajuli","full_name":"Parajuli, Laxmi K"},{"first_name":"Chikako","last_name":"Nakajima","full_name":"Nakajima, Chikako"},{"full_name":"Kulik, Ákos","first_name":"Ákos","last_name":"Kulik"},{"full_name":"Matsui, Ko","last_name":"Matsui","first_name":"Ko"},{"full_name":"Schneider, Toni","last_name":"Schneider","first_name":"Toni"},{"full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"}],"publisher":"Society for Neuroscience","intvolume":" 32","status":"public","publication_status":"published","title":"Quantitative regional and ultra structural localization of the Ca v2 3 subunit of R type calcium channel in mouse brain","year":"2012","_id":"2689","extern":1,"issue":"39","publist_id":"4208","abstract":[{"lang":"eng","text":"R-type calcium channels (RTCCs) are well known for their role in synaptic plasticity, but little is known about their subcellular distribution across various neuronal compartments. Using subtype-specific antibodies, we characterized the regional and subcellular localization of Ca v2.3 in mice and rats at both light and electron microscopic levels. Ca v2.3 immunogold particles were found to be predominantly presynaptic in the interpeduncular nucleus, but postsynaptic in other brain regions. Serial section analysis of electron microscopic images from the hippocampal CA1 revealed a higher density of immunogold particles in the dendritic shaft plasma membrane compared with the pyramidal cell somata. However, the labeling densities were not significantly different among the apical, oblique, or basal dendrites. Immunogold particles were also observed over the plasma membrane of dendritic spines, including both synaptic and extrasynaptic sites. Individual spine heads contained <20 immunogold particles, with an average density of ~260 immunoparticles per μm 3 spine head volume, in accordance with the density of RTCCs estimated using calcium imaging (Sabatini and Svoboda, 2000). The Ca v2.3 density was variable among similar-sized spine heads and did not correlate with the density in the parent dendrite, implying that spines are individual calcium compartments operating autonomously from their parent dendrites."}],"type":"journal_article"},{"abstract":[{"text":"Left-right asymmetry of human brain function has been known for a century, although much of molecular and cellular basis of brain laterality remains to be elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are asymmetrically arranged, however, the functional implication of the asymmetrical circuitry has not been studied at the behavioral level. In order to address the left-right asymmetry of hippocampal function in behaving mice, we analyzed the performance of "split-brain" mice in the Barnes maze. The "split-brain" mice received ventral hippocampal commissure and corpus callosum transection in addition to deprivation of visual input from one eye. In such mice, the hippocampus in the side of visual deprivation receives sensory-driven input. Better spatial task performance was achieved by the mice which were forced to use the right hippocampus than those which were forced to use the left hippocampus. In two-choice spatial maze, forced usage of left hippocampus resulted in a comparable performance to the right counterpart, suggesting that both hippocampal hemispheres are capable of conducting spatial learning. Therefore, the results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.","lang":"eng"}],"publist_id":"4210","issue":"2","extern":1,"type":"journal_article","author":[{"first_name":"Yoshiaki","last_name":"Shinohara","full_name":"Shinohara, Yoshiaki"},{"last_name":"Hosoya","first_name":"Aki","full_name":"Hosoya, Aki"},{"full_name":"Yamasaki, Nobuyuki","first_name":"Nobuyuki","last_name":"Yamasaki"},{"full_name":"Ahmed, Hassan","first_name":"Hassan","last_name":"Ahmed"},{"last_name":"Hattori","first_name":"Satoko","full_name":"Hattori, Satoko"},{"last_name":"Eguchi","first_name":"Megumi","full_name":"Eguchi, Megumi"},{"full_name":"Yamaguchi, Shun","last_name":"Yamaguchi","first_name":"Shun"},{"last_name":"Miyakawa","first_name":"Tsuyoshi","full_name":"Miyakawa, Tsuyoshi"},{"full_name":"Hirase, Hajime","last_name":"Hirase","first_name":"Hajime"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto"}],"date_created":"2018-12-11T11:59:04Z","date_updated":"2021-01-12T06:59:03Z","volume":22,"_id":"2687","year":"2012","publication_status":"published","title":"Right-hemispheric dominance of spatial memory in split-brain mice","status":"public","intvolume":" 22","publisher":"Wiley-Blackwell","day":"01","month":"01","doi":"10.1002/hipo.20886","date_published":"2012-01-01T00:00:00Z","publication":"Hippocampus","citation":{"chicago":"Shinohara, Yoshiaki, Aki Hosoya, Nobuyuki Yamasaki, Hassan Ahmed, Satoko Hattori, Megumi Eguchi, Shun Yamaguchi, Tsuyoshi Miyakawa, Hajime Hirase, and Ryuichi Shigemoto. “Right-Hemispheric Dominance of Spatial Memory in Split-Brain Mice.” Hippocampus. Wiley-Blackwell, 2012. https://doi.org/10.1002/hipo.20886.","short":"Y. Shinohara, A. Hosoya, N. Yamasaki, H. Ahmed, S. Hattori, M. Eguchi, S. Yamaguchi, T. Miyakawa, H. Hirase, R. Shigemoto, Hippocampus 22 (2012) 117–121.","mla":"Shinohara, Yoshiaki, et al. “Right-Hemispheric Dominance of Spatial Memory in Split-Brain Mice.” Hippocampus, vol. 22, no. 2, Wiley-Blackwell, 2012, pp. 117–21, doi:10.1002/hipo.20886.","apa":"Shinohara, Y., Hosoya, A., Yamasaki, N., Ahmed, H., Hattori, S., Eguchi, M., … Shigemoto, R. (2012). Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus. Wiley-Blackwell. https://doi.org/10.1002/hipo.20886","ieee":"Y. Shinohara et al., “Right-hemispheric dominance of spatial memory in split-brain mice,” Hippocampus, vol. 22, no. 2. Wiley-Blackwell, pp. 117–121, 2012.","ista":"Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi S, Miyakawa T, Hirase H, Shigemoto R. 2012. Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus. 22(2), 117–121.","ama":"Shinohara Y, Hosoya A, Yamasaki N, et al. Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus. 2012;22(2):117-121. doi:10.1002/hipo.20886"},"quality_controlled":0,"page":"117 - 121"},{"date_published":"2012-06-01T00:00:00Z","doi":"10.1016/j.conb.2012.01.006","page":"446 - 452","quality_controlled":0,"citation":{"apa":"Fukazawa, Y., & Shigemoto, R. (2012). Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2012.01.006","ieee":"Y. Fukazawa and R. Shigemoto, “Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression,” Current Opinion in Neurobiology, vol. 22, no. 3. Elsevier, pp. 446–452, 2012.","ista":"Fukazawa Y, Shigemoto R. 2012. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 22(3), 446–452.","ama":"Fukazawa Y, Shigemoto R. Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 2012;22(3):446-452. doi:10.1016/j.conb.2012.01.006","chicago":"Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” Current Opinion in Neurobiology. Elsevier, 2012. https://doi.org/10.1016/j.conb.2012.01.006.","short":"Y. Fukazawa, R. Shigemoto, Current Opinion in Neurobiology 22 (2012) 446–452.","mla":"Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type Relationships between Synaptic Size and AMPAR Expression.” Current Opinion in Neurobiology, vol. 22, no. 3, Elsevier, 2012, pp. 446–52, doi:10.1016/j.conb.2012.01.006."},"publication":"Current Opinion in Neurobiology","day":"01","month":"06","volume":22,"date_created":"2018-12-11T11:59:04Z","date_updated":"2021-01-12T06:59:03Z","author":[{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"},{"last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto"}],"intvolume":" 22","publisher":"Elsevier","publication_status":"published","title":"Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression","status":"public","_id":"2688","year":"2012","extern":1,"issue":"3","publist_id":"4209","abstract":[{"text":"To gain insights into structure-function relationship of excitatory synapses, we revisit our quantitative analysis of synaptic AMPAR by highly sensitive freeze-fracture replica labeling in eight different connections. All of these connections showed linear correlation between synapse size and AMPAR number indicating a common intra-synapse-type relationship in CNS synapses. On the contrary, inter-synapse-type relationship is unexpected indicating no correlation between averages of synapse size and AMPAR number. Interestingly, connections with large average synapse size and low AMPAR density showed high variability of AMPAR number and mosaic distribution within the postsynaptic membrane. We propose an idea that these connections may quickly exhibit synaptic plasticity by modifying AMPAR density/number whereas those with high AMPAR density change their efficacy by modifying synapse size.","lang":"eng"}],"type":"journal_article"},{"date_created":"2018-12-11T11:59:07Z","date_updated":"2021-01-12T06:59:06Z","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös","full_name":"László Erdös"}],"status":"public","publication_status":"published","title":"Universality for random matrices and log-gases","publisher":"ArXiv","year":"2012","_id":"2696","extern":1,"publist_id":"4201","type":"preprint","date_published":"2012-12-04T00:00:00Z","quality_controlled":0,"publication":"ArXiv","citation":{"mla":"Erdös, László. “Universality for Random Matrices and Log-Gases.” ArXiv, ArXiv, 2012.","short":"L. Erdös, ArXiv (2012).","chicago":"Erdös, László. “Universality for Random Matrices and Log-Gases.” ArXiv. ArXiv, 2012.","ama":"Erdös L. Universality for random matrices and log-gases. ArXiv. 2012.","ista":"Erdös L. 2012. Universality for random matrices and log-gases. ArXiv, .","apa":"Erdös, L. (2012). Universality for random matrices and log-gases. ArXiv. ArXiv.","ieee":"L. Erdös, “Universality for random matrices and log-gases,” ArXiv. ArXiv, 2012."},"oa":1,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1212.0839"}],"month":"12","day":"04"},{"publication_status":"published","status":"public","title":"Lecture notes on quantum Brownian motion","publisher":"Oxford University Press","intvolume":" 95","_id":"2700","year":"2012","date_created":"2018-12-11T11:59:08Z","date_updated":"2021-01-12T06:59:08Z","volume":95,"author":[{"full_name":"László Erdös","first_name":"László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603"}],"alternative_title":["Quantum Theory from Small to Large Scales"],"type":"conference","extern":1,"publist_id":"4196","quality_controlled":0,"page":"3 - 98","main_file_link":[{"url":"http://arxiv.org/abs/1009.0843","open_access":"1"}],"oa":1,"citation":{"short":"L. Erdös, in:, Oxford University Press, 2012, pp. 3–98.","mla":"Erdös, László. Lecture Notes on Quantum Brownian Motion. Vol. 95, Oxford University Press, 2012, pp. 3–98.","chicago":"Erdös, László. “Lecture Notes on Quantum Brownian Motion,” 95:3–98. Oxford University Press, 2012.","ama":"Erdös L. Lecture notes on quantum Brownian motion. In: Vol 95. Oxford University Press; 2012:3-98.","ieee":"L. Erdös, “Lecture notes on quantum Brownian motion,” presented at the Les Houches Summer School 2010, 2012, vol. 95, pp. 3–98.","apa":"Erdös, L. (2012). Lecture notes on quantum Brownian motion (Vol. 95, pp. 3–98). Presented at the Les Houches Summer School 2010, Oxford University Press.","ista":"Erdös L. 2012. Lecture notes on quantum Brownian motion. Les Houches Summer School 2010, Quantum Theory from Small to Large Scales, vol. 95, 3–98."},"conference":{"name":"Les Houches Summer School 2010"},"date_published":"2012-05-24T00:00:00Z","month":"05","day":"24"}]