[{"volume":82,"date_updated":"2021-01-12T06:53:13Z","date_created":"2018-12-11T11:54:01Z","author":[{"last_name":"Baek","first_name":"Seungtae","full_name":"Baek, SeungTae"},{"full_name":"Kerjan, Géraldine","last_name":"Kerjan","first_name":"Géraldine"},{"last_name":"Bielas","first_name":"Stephanie","full_name":"Bielas, Stephanie L"},{"first_name":"Jieun","last_name":"Lee","full_name":"Lee, Jieun"},{"first_name":"Ali","last_name":"Fenstermaker","full_name":"Fenstermaker, Ali G"},{"full_name":"Gaia Novarino","first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178"},{"full_name":"Gleeson, Joseph G","first_name":"Joseph","last_name":"Gleeson"}],"intvolume":" 82","publisher":"Elsevier","status":"public","title":"Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous MicroRNA dysregulation","publication_status":"published","_id":"1791","acknowledgement":"This work was supported by the National Institutes of Health R01NS41537. G.K. was supported by an EMBO Long Term Fellowship, S.L.B. by the A.P. Giannini Fellowship, and A.G.F. by the Brain Behavior Research Foundation","year":"2014","extern":1,"issue":"6","publist_id":"5322","abstract":[{"text":"Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortical neuronal migration phenotype. Here we report that in utero electroporation of shRNA, but not siRNA or miRNA, to Dcx demonstrates a migration phenotype in Dcx knockouts akin to the effect in wild-type mice, suggestingshRNA-mediated off-target toxicity. This effect wasnot limited to Dcx, as it was observed in Dclk1 knockouts, as well as with a fraction of scrambled shRNAs, suggesting a sequence-dependent but not sequence-specific effect. Profiling RNAs from electroporated cells showed a defect in endogenous let7 miRNA levels, and disruption of let7 or Dicer recapitulated the migration defect. The results suggest that shRNA-mediated knockdown can produce untoward migration effects by altering endogenous miRNA pathways.","lang":"eng"}],"type":"journal_article","doi":"10.1016/j.neuron.2014.04.036","date_published":"2014-06-18T00:00:00Z","page":"1255 - 1262","quality_controlled":0,"citation":{"chicago":"Baek, Seungtae, Géraldine Kerjan, Stephanie Bielas, Jieun Lee, Ali Fenstermaker, Gaia Novarino, and Joseph Gleeson. “Off-Target Effect of Doublecortin Family ShRNA on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation.” Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.04.036.","short":"S. Baek, G. Kerjan, S. Bielas, J. Lee, A. Fenstermaker, G. Novarino, J. Gleeson, Neuron 82 (2014) 1255–1262.","mla":"Baek, Seungtae, et al. “Off-Target Effect of Doublecortin Family ShRNA on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation.” Neuron, vol. 82, no. 6, Elsevier, 2014, pp. 1255–62, doi:10.1016/j.neuron.2014.04.036.","ieee":"S. Baek et al., “Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous MicroRNA dysregulation,” Neuron, vol. 82, no. 6. Elsevier, pp. 1255–1262, 2014.","apa":"Baek, S., Kerjan, G., Bielas, S., Lee, J., Fenstermaker, A., Novarino, G., & Gleeson, J. (2014). Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous MicroRNA dysregulation. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.04.036","ista":"Baek S, Kerjan G, Bielas S, Lee J, Fenstermaker A, Novarino G, Gleeson J. 2014. Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous MicroRNA dysregulation. Neuron. 82(6), 1255–1262.","ama":"Baek S, Kerjan G, Bielas S, et al. Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous MicroRNA dysregulation. Neuron. 2014;82(6):1255-1262. doi:10.1016/j.neuron.2014.04.036"},"publication":"Neuron","day":"18","month":"06"},{"day":"01","month":"04","scopus_import":1,"language":[{"iso":"eng"}],"doi":"10.1007/978-3-7091-1526-8_8","date_published":"2014-04-01T00:00:00Z","quality_controlled":"1","page":"143 - 170","publication":"Auxin and Its Role in Plant Development","citation":{"chicago":"Baster, Pawel, and Jiří Friml. “Auxin on the Road Navigated by Cellular PIN Polarity.” In Auxin and Its Role in Plant Development, edited by Eva Zažímalová, Jan Petrášek, and Eva Benková, 143–70. Springer, 2014. https://doi.org/10.1007/978-3-7091-1526-8_8.","short":"P. Baster, J. Friml, in:, E. Zažímalová, J. Petrášek, E. Benková (Eds.), Auxin and Its Role in Plant Development, Springer, 2014, pp. 143–170.","mla":"Baster, Pawel, and Jiří Friml. “Auxin on the Road Navigated by Cellular PIN Polarity.” Auxin and Its Role in Plant Development, edited by Eva Zažímalová et al., Springer, 2014, pp. 143–70, doi:10.1007/978-3-7091-1526-8_8.","apa":"Baster, P., & Friml, J. (2014). Auxin on the road navigated by cellular PIN polarity. In E. Zažímalová, J. Petrášek, & E. Benková (Eds.), Auxin and Its Role in Plant Development (pp. 143–170). Springer. https://doi.org/10.1007/978-3-7091-1526-8_8","ieee":"P. Baster and J. Friml, “Auxin on the road navigated by cellular PIN polarity,” in Auxin and Its Role in Plant Development, E. Zažímalová, J. Petrášek, and E. Benková, Eds. Springer, 2014, pp. 143–170.","ista":"Baster P, Friml J. 2014.Auxin on the road navigated by cellular PIN polarity. In: Auxin and Its Role in Plant Development. , 143–170.","ama":"Baster P, Friml J. Auxin on the road navigated by cellular PIN polarity. In: Zažímalová E, Petrášek J, Benková E, eds. Auxin and Its Role in Plant Development. Springer; 2014:143-170. doi:10.1007/978-3-7091-1526-8_8"},"abstract":[{"lang":"eng","text":"The generation of asymmetry, at both cellular and tissue level, is one of the most essential capabilities of all eukaryotic organisms. It mediates basically all multicellular development ranging from embryogenesis and de novo organ formation till responses to various environmental stimuli. In plants, the awe-inspiring number of such processes is regulated by phytohormone auxin and its directional, cell-to-cell transport. The mediators of this transport, PIN auxin transporters, are asymmetrically localized at the plasma membrane, and this polar localization determines the directionality of intercellular auxin flow. Thus, auxin transport contributes crucially to the generation of local auxin gradients or maxima, which instruct given cell to change its developmental program. Here, we introduce and discuss the molecular components and cellular mechanisms regulating the generation and maintenance of cellular PIN polarity, as the general hallmarks of cell polarity in plants."}],"publist_id":"5304","type":"book_chapter","date_updated":"2021-01-12T06:53:19Z","date_created":"2018-12-11T11:54:07Z","oa_version":"None","author":[{"full_name":"Baster, Pawel","id":"3028BD74-F248-11E8-B48F-1D18A9856A87","last_name":"Baster","first_name":"Pawel"},{"first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří"}],"title":"Auxin on the road navigated by cellular PIN polarity","status":"public","publication_status":"published","editor":[{"full_name":"Zažímalová, Eva","last_name":"Zažímalová","first_name":"Eva"},{"full_name":"Petrášek, Jan","first_name":"Jan","last_name":"Petrášek"},{"full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","first_name":"Eva","last_name":"Benková"}],"department":[{"_id":"JiFr"}],"publisher":"Springer","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"1806","year":"2014"},{"day":"16","has_accepted_license":"1","scopus_import":1,"date_published":"2014-03-16T00:00:00Z","publication":"International Journal of Computational Geometry and Applications","citation":{"ista":"Huber S, Held M, Meerwald P, Kwitt R. 2014. Topology-preserving watermarking of vector graphics. International Journal of Computational Geometry and Applications. 24(1), 61–86.","ieee":"S. Huber, M. Held, P. Meerwald, and R. Kwitt, “Topology-preserving watermarking of vector graphics,” International Journal of Computational Geometry and Applications, vol. 24, no. 1. World Scientific Publishing, pp. 61–86, 2014.","apa":"Huber, S., Held, M., Meerwald, P., & Kwitt, R. (2014). Topology-preserving watermarking of vector graphics. International Journal of Computational Geometry and Applications. World Scientific Publishing. https://doi.org/10.1142/S0218195914500034","ama":"Huber S, Held M, Meerwald P, Kwitt R. Topology-preserving watermarking of vector graphics. International Journal of Computational Geometry and Applications. 2014;24(1):61-86. doi:10.1142/S0218195914500034","chicago":"Huber, Stefan, Martin Held, Peter Meerwald, and Roland Kwitt. “Topology-Preserving Watermarking of Vector Graphics.” International Journal of Computational Geometry and Applications. World Scientific Publishing, 2014. https://doi.org/10.1142/S0218195914500034.","mla":"Huber, Stefan, et al. “Topology-Preserving Watermarking of Vector Graphics.” International Journal of Computational Geometry and Applications, vol. 24, no. 1, World Scientific Publishing, 2014, pp. 61–86, doi:10.1142/S0218195914500034.","short":"S. Huber, M. Held, P. Meerwald, R. Kwitt, International Journal of Computational Geometry and Applications 24 (2014) 61–86."},"page":"61 - 86","abstract":[{"lang":"eng","text":"Watermarking techniques for vector graphics dislocate vertices in order to embed imperceptible, yet detectable, statistical features into the input data. The embedding process may result in a change of the topology of the input data, e.g., by introducing self-intersections, which is undesirable or even disastrous for many applications. In this paper we present a watermarking framework for two-dimensional vector graphics that employs conventional watermarking techniques but still provides the guarantee that the topology of the input data is preserved. The geometric part of this framework computes so-called maximum perturbation regions (MPR) of vertices. We propose two efficient algorithms to compute MPRs based on Voronoi diagrams and constrained triangulations. Furthermore, we present two algorithms to conditionally correct the watermarked data in order to increase the watermark embedding capacity and still guarantee topological correctness. While we focus on the watermarking of input formed by straight-line segments, one of our approaches can also be extended to circular arcs. We conclude the paper by demonstrating and analyzing the applicability of our framework in conjunction with two well-known watermarking techniques."}],"issue":"1","type":"journal_article","pubrep_id":"443","oa_version":"Published Version","file":[{"relation":"main_file","file_id":"4704","checksum":"be45c133ab4d43351260e21beaa8f4b1","date_updated":"2020-07-14T12:45:17Z","date_created":"2018-12-12T10:08:43Z","access_level":"open_access","file_name":"IST-2016-443-v1+1_S0218195914500034.pdf","content_type":"application/pdf","file_size":991734,"creator":"system"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1816","status":"public","title":"Topology-preserving watermarking of vector graphics","ddc":["000"],"intvolume":" 24","month":"03","doi":"10.1142/S0218195914500034","language":[{"iso":"eng"}],"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"quality_controlled":"1","file_date_updated":"2020-07-14T12:45:17Z","publist_id":"5290","author":[{"id":"4700A070-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8871-5814","first_name":"Stefan","last_name":"Huber","full_name":"Huber, Stefan"},{"full_name":"Held, Martin","first_name":"Martin","last_name":"Held"},{"full_name":"Meerwald, Peter","last_name":"Meerwald","first_name":"Peter"},{"full_name":"Kwitt, Roland","last_name":"Kwitt","first_name":"Roland"}],"date_created":"2018-12-11T11:54:10Z","date_updated":"2021-01-12T06:53:23Z","volume":24,"year":"2014","acknowledgement":"Work by Martin Held and Stefan Huber was supported by Austrian Science Fund (FWF): L367-N15 and P25816-N15.","publication_status":"published","department":[{"_id":"HeEd"}],"publisher":"World Scientific Publishing"},{"year":"2014","publication_status":"published","publisher":"American Institute of Physics","department":[{"_id":"RoSe"}],"author":[{"first_name":"Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert"}],"date_created":"2018-12-11T11:54:11Z","date_updated":"2021-01-12T06:53:25Z","volume":55,"article_number":"1.4881536","file_date_updated":"2020-07-14T12:45:17Z","publist_id":"5285","oa":1,"quality_controlled":"1","project":[{"_id":"26450934-B435-11E9-9278-68D0E5697425","name":"NSERC Postdoctoral fellowship"}],"doi":"10.1063/1.4881536","language":[{"iso":"eng"}],"month":"06","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"1821","status":"public","title":"Bose gases, Bose-Einstein condensation, and the Bogoliubov approximation","ddc":["510","530"],"intvolume":" 55","pubrep_id":"532","file":[{"file_id":"5172","relation":"main_file","checksum":"ed0efc93c10f1341155f0316af617b82","date_updated":"2020-07-14T12:45:17Z","date_created":"2018-12-12T10:15:49Z","access_level":"open_access","file_name":"IST-2016-532-v1+1_J._Mathematical_Phys._2014_Seiringer.pdf","creator":"system","content_type":"application/pdf","file_size":269171}],"oa_version":"Submitted Version","type":"journal_article","abstract":[{"text":"We review recent progress towards a rigorous understanding of the Bogoliubov approximation for bosonic quantum many-body systems. We focus, in particular, on the excitation spectrum of a Bose gas in the mean-field (Hartree) limit. A list of open problems will be discussed at the end.","lang":"eng"}],"issue":"7","publication":"Journal of Mathematical Physics","citation":{"ieee":"R. Seiringer, “Bose gases, Bose-Einstein condensation, and the Bogoliubov approximation,” Journal of Mathematical Physics, vol. 55, no. 7. American Institute of Physics, 2014.","apa":"Seiringer, R. (2014). Bose gases, Bose-Einstein condensation, and the Bogoliubov approximation. Journal of Mathematical Physics. American Institute of Physics. https://doi.org/10.1063/1.4881536","ista":"Seiringer R. 2014. Bose gases, Bose-Einstein condensation, and the Bogoliubov approximation. Journal of Mathematical Physics. 55(7), 1.4881536.","ama":"Seiringer R. Bose gases, Bose-Einstein condensation, and the Bogoliubov approximation. Journal of Mathematical Physics. 2014;55(7). doi:10.1063/1.4881536","chicago":"Seiringer, Robert. “Bose Gases, Bose-Einstein Condensation, and the Bogoliubov Approximation.” Journal of Mathematical Physics. American Institute of Physics, 2014. https://doi.org/10.1063/1.4881536.","short":"R. Seiringer, Journal of Mathematical Physics 55 (2014).","mla":"Seiringer, Robert. “Bose Gases, Bose-Einstein Condensation, and the Bogoliubov Approximation.” Journal of Mathematical Physics, vol. 55, no. 7, 1.4881536, American Institute of Physics, 2014, doi:10.1063/1.4881536."},"date_published":"2014-06-26T00:00:00Z","scopus_import":1,"day":"26","has_accepted_license":"1"},{"publication":"Journal of Mathematical Physics","citation":{"ista":"Jakšić V, Pillet C, Seiringer R. 2014. Introduction. Journal of Mathematical Physics. 55(7), 075101.","apa":"Jakšić, V., Pillet, C., & Seiringer, R. (2014). Introduction. Journal of Mathematical Physics. American Institute of Physics. https://doi.org/10.1063/1.4884877","ieee":"V. Jakšić, C. Pillet, and R. Seiringer, “Introduction,” Journal of Mathematical Physics, vol. 55, no. 7. American Institute of Physics, 2014.","ama":"Jakšić V, Pillet C, Seiringer R. Introduction. Journal of Mathematical Physics. 2014;55(7). doi:10.1063/1.4884877","chicago":"Jakšić, Vojkan, Claude Pillet, and Robert Seiringer. “Introduction.” Journal of Mathematical Physics. American Institute of Physics, 2014. https://doi.org/10.1063/1.4884877.","mla":"Jakšić, Vojkan, et al. “Introduction.” Journal of Mathematical Physics, vol. 55, no. 7, 075101, American Institute of Physics, 2014, doi:10.1063/1.4884877.","short":"V. Jakšić, C. Pillet, R. Seiringer, Journal of Mathematical Physics 55 (2014)."},"quality_controlled":"1","date_published":"2014-07-01T00:00:00Z","doi":"10.1063/1.4884877","language":[{"iso":"eng"}],"scopus_import":1,"month":"07","day":"01","_id":"1822","year":"2014","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","title":"Introduction","status":"public","publication_status":"published","intvolume":" 55","publisher":"American Institute of Physics","department":[{"_id":"RoSe"}],"author":[{"full_name":"Jakšić, Vojkan","first_name":"Vojkan","last_name":"Jakšić"},{"full_name":"Pillet, Claude","last_name":"Pillet","first_name":"Claude"},{"last_name":"Seiringer","first_name":"Robert","orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert"}],"date_updated":"2021-01-12T06:53:25Z","date_created":"2018-12-11T11:54:12Z","oa_version":"None","volume":55,"article_number":"075101","type":"journal_article","issue":"7","publist_id":"5284"}]