[{"ddc":["510"],"status":"public","title":"Asymmetric Ramsey properties of random graphs involving cliques and cycles","intvolume":" 62","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"11706","file":[{"checksum":"3a5969d0c512aef01c30f3dc81c6d59b","success":1,"date_updated":"2023-10-04T09:37:26Z","date_created":"2023-10-04T09:37:26Z","relation":"main_file","file_id":"14389","content_type":"application/pdf","file_size":1362334,"creator":"dernst","access_level":"open_access","file_name":"2023_RandomStructureAlgorithms_Liebenau.pdf"}],"oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"We say that (Formula presented.) if, in every edge coloring (Formula presented.), we can find either a 1-colored copy of (Formula presented.) or a 2-colored copy of (Formula presented.). The well-known states that the threshold for the property (Formula presented.) is equal to (Formula presented.), where (Formula presented.) is given by (Formula presented.) for any pair of graphs (Formula presented.) and (Formula presented.) with (Formula presented.). In this article, we show the 0-statement of the Kohayakawa–Kreuter conjecture for every pair of cycles and cliques. "}],"issue":"4","article_type":"original","page":"1035-1055","publication":"Random Structures and Algorithms","citation":{"ieee":"A. Liebenau, L. Mattos, W. Mendonca dos Santos, and J. Skokan, “Asymmetric Ramsey properties of random graphs involving cliques and cycles,” Random Structures and Algorithms, vol. 62, no. 4. Wiley, pp. 1035–1055, 2023.","apa":"Liebenau, A., Mattos, L., Mendonca dos Santos, W., & Skokan, J. (2023). Asymmetric Ramsey properties of random graphs involving cliques and cycles. Random Structures and Algorithms. Wiley. https://doi.org/10.1002/rsa.21106","ista":"Liebenau A, Mattos L, Mendonca dos Santos W, Skokan J. 2023. Asymmetric Ramsey properties of random graphs involving cliques and cycles. Random Structures and Algorithms. 62(4), 1035–1055.","ama":"Liebenau A, Mattos L, Mendonca dos Santos W, Skokan J. Asymmetric Ramsey properties of random graphs involving cliques and cycles. Random Structures and Algorithms. 2023;62(4):1035-1055. doi:10.1002/rsa.21106","chicago":"Liebenau, Anita, Letícia Mattos, Walner Mendonca dos Santos, and Jozef Skokan. “Asymmetric Ramsey Properties of Random Graphs Involving Cliques and Cycles.” Random Structures and Algorithms. Wiley, 2023. https://doi.org/10.1002/rsa.21106.","short":"A. Liebenau, L. Mattos, W. Mendonca dos Santos, J. Skokan, Random Structures and Algorithms 62 (2023) 1035–1055.","mla":"Liebenau, Anita, et al. “Asymmetric Ramsey Properties of Random Graphs Involving Cliques and Cycles.” Random Structures and Algorithms, vol. 62, no. 4, Wiley, 2023, pp. 1035–55, doi:10.1002/rsa.21106."},"date_published":"2023-07-01T00:00:00Z","scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","publication_status":"published","publisher":"Wiley","department":[{"_id":"MaKw"}],"acknowledgement":"This work was started at the thematic program GRAPHS@IMPA (January–March 2018), in Rio de Janeiro. We thank IMPA and the organisers for the hospitality and for providing a pleasant research environment. We thank Rob Morris for helpful discussions, and the anonymous referees for their careful reading and many helpful suggestions. Open Access funding enabled and organized by Projekt DEAL.\r\nA. Liebenau was supported by an ARC DECRA Fellowship Grant DE170100789. L. Mattos was supported by CAPES and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – The Berlin Mathematics Research Center MATH+ (EXC-2046/1, project ID: 390685689). W. Mendonça was supported by CAPES project 88882.332408/2010-01.","year":"2023","date_updated":"2023-10-04T09:38:45Z","date_created":"2022-07-31T22:01:49Z","volume":62,"author":[{"full_name":"Liebenau, Anita","first_name":"Anita","last_name":"Liebenau"},{"full_name":"Mattos, Letícia","first_name":"Letícia","last_name":"Mattos"},{"id":"12c6bd4d-2cd0-11ec-a0da-e28f42f65ebd","last_name":"Mendonca Dos Santos","first_name":"Walner","full_name":"Mendonca Dos Santos, Walner"},{"first_name":"Jozef","last_name":"Skokan","full_name":"Skokan, Jozef"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","file_date_updated":"2023-10-04T09:37:26Z","isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"oa":1,"external_id":{"isi":["000828530400001"]},"language":[{"iso":"eng"}],"doi":"10.1002/rsa.21106","month":"07","publication_identifier":{"eissn":["1098-2418"],"issn":["1042-9832"]}},{"_id":"12707","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Small deviation estimates for the largest eigenvalue of Wigner matrices","status":"public","intvolume":" 29","oa_version":"Preprint","type":"journal_article","abstract":[{"text":"We establish precise right-tail small deviation estimates for the largest eigenvalue of real symmetric and complex Hermitian matrices whose entries are independent random variables with uniformly bounded moments. The proof relies on a Green function comparison along a continuous interpolating matrix flow for a long time. Less precise estimates are also obtained in the left tail.","lang":"eng"}],"issue":"2","publication":"Bernoulli","citation":{"chicago":"Erdös, László, and Yuanyuan Xu. “Small Deviation Estimates for the Largest Eigenvalue of Wigner Matrices.” Bernoulli. Bernoulli Society for Mathematical Statistics and Probability, 2023. https://doi.org/10.3150/22-BEJ1490.","short":"L. Erdös, Y. Xu, Bernoulli 29 (2023) 1063–1079.","mla":"Erdös, László, and Yuanyuan Xu. “Small Deviation Estimates for the Largest Eigenvalue of Wigner Matrices.” Bernoulli, vol. 29, no. 2, Bernoulli Society for Mathematical Statistics and Probability, 2023, pp. 1063–79, doi:10.3150/22-BEJ1490.","apa":"Erdös, L., & Xu, Y. (2023). Small deviation estimates for the largest eigenvalue of Wigner matrices. Bernoulli. Bernoulli Society for Mathematical Statistics and Probability. https://doi.org/10.3150/22-BEJ1490","ieee":"L. Erdös and Y. Xu, “Small deviation estimates for the largest eigenvalue of Wigner matrices,” Bernoulli, vol. 29, no. 2. Bernoulli Society for Mathematical Statistics and Probability, pp. 1063–1079, 2023.","ista":"Erdös L, Xu Y. 2023. Small deviation estimates for the largest eigenvalue of Wigner matrices. Bernoulli. 29(2), 1063–1079.","ama":"Erdös L, Xu Y. Small deviation estimates for the largest eigenvalue of Wigner matrices. Bernoulli. 2023;29(2):1063-1079. doi:10.3150/22-BEJ1490"},"article_type":"original","page":"1063-1079","date_published":"2023-05-01T00:00:00Z","scopus_import":"1","day":"01","article_processing_charge":"No","year":"2023","publication_status":"published","department":[{"_id":"LaEr"}],"publisher":"Bernoulli Society for Mathematical Statistics and Probability","author":[{"orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","full_name":"Erdös, László"},{"full_name":"Xu, Yuanyuan","orcid":"0000-0003-1559-1205","id":"7902bdb1-a2a4-11eb-a164-c9216f71aea3","last_name":"Xu","first_name":"Yuanyuan"}],"date_updated":"2023-10-04T10:21:07Z","date_created":"2023-03-05T23:01:05Z","volume":29,"ec_funded":1,"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/2112.12093","open_access":"1"}],"external_id":{"arxiv":["2112.12093 "],"isi":["000947270100008"]},"isi":1,"quality_controlled":"1","project":[{"name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"doi":"10.3150/22-BEJ1490","language":[{"iso":"eng"}],"month":"05","publication_identifier":{"issn":["1350-7265"]}},{"language":[{"iso":"eng"}],"doi":"10.1038/s41567-023-01977-w","project":[{"grant_number":"680037","_id":"B6FC0238-B512-11E9-945C-1524E6697425","call_identifier":"H2020","name":"Coordination of Patterning And Growth In the Spinal Cord"},{"name":"Mechanisms of tissue size regulation in spinal cord development","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa","grant_number":"101044579"},{"name":"Morphogen control of growth and pattern in the spinal cord","grant_number":"F07802","_id":"059DF620-7A3F-11EA-A408-12923DDC885E"},{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"quality_controlled":"1","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000964029300003"]},"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"month":"07","volume":19,"date_created":"2023-04-16T22:01:09Z","date_updated":"2023-10-04T11:14:05Z","related_material":{"record":[{"id":"13081","relation":"dissertation_contains","status":"public"}]},"author":[{"first_name":"Laura","last_name":"Bocanegra","id":"4896F754-F248-11E8-B48F-1D18A9856A87","full_name":"Bocanegra, Laura"},{"full_name":"Singh, Amrita","id":"76250f9f-3a21-11eb-9a80-a6180a0d7958","last_name":"Singh","first_name":"Amrita"},{"last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B"},{"full_name":"Zagórski, Marcin P","orcid":"0000-0001-7896-7762","id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","last_name":"Zagórski","first_name":"Marcin P"},{"full_name":"Kicheva, Anna","last_name":"Kicheva","first_name":"Anna","orcid":"0000-0003-4509-4998","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"}],"publisher":"Springer Nature","department":[{"_id":"EdHa"},{"_id":"AnKi"}],"publication_status":"published","acknowledgement":"We thank S. Hippenmeyer for the reagents and C. P. Heisenberg, J. Briscoe and K. Page for comments on the manuscript. This work was supported by IST Austria; the European Research Council under Horizon 2020 research and innovation programme grant no. 680037 and Horizon Europe grant 101044579 (A.K.); Austrian Science Fund (FWF): F78 (Stem Cell Modulation) (A.K.); ISTFELLOW postdoctoral program (A.S.); Narodowe Centrum Nauki, Poland SONATA, 2017/26/D/NZ2/00454 (M.Z.); and the Polish National Agency for Academic Exchange (M.Z.).","year":"2023","license":"https://creativecommons.org/licenses/by/4.0/","ec_funded":1,"file_date_updated":"2023-10-04T11:13:28Z","date_published":"2023-07-01T00:00:00Z","page":"1050-1058","article_type":"original","citation":{"chicago":"Bocanegra, Laura, Amrita Singh, Edouard B Hannezo, Marcin P Zagórski, and Anna Kicheva. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.” Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-01977-w.","mla":"Bocanegra, Laura, et al. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.” Nature Physics, vol. 19, Springer Nature, 2023, pp. 1050–58, doi:10.1038/s41567-023-01977-w.","short":"L. Bocanegra, A. Singh, E.B. Hannezo, M.P. Zagórski, A. Kicheva, Nature Physics 19 (2023) 1050–1058.","ista":"Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. 2023. Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics. 19, 1050–1058.","ieee":"L. Bocanegra, A. Singh, E. B. Hannezo, M. P. Zagórski, and A. Kicheva, “Cell cycle dynamics control fluidity of the developing mouse neuroepithelium,” Nature Physics, vol. 19. Springer Nature, pp. 1050–1058, 2023.","apa":"Bocanegra, L., Singh, A., Hannezo, E. B., Zagórski, M. P., & Kicheva, A. (2023). Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-023-01977-w","ama":"Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics. 2023;19:1050-1058. doi:10.1038/s41567-023-01977-w"},"publication":"Nature Physics","has_accepted_license":"1","article_processing_charge":"No","day":"01","scopus_import":"1","file":[{"relation":"main_file","file_id":"14392","checksum":"858225a4205b74406e5045006cdd853f","success":1,"date_created":"2023-10-04T11:13:28Z","date_updated":"2023-10-04T11:13:28Z","access_level":"open_access","file_name":"2023_NaturePhysics_Boncanegra.pdf","content_type":"application/pdf","file_size":5532285,"creator":"dernst"}],"oa_version":"Published Version","intvolume":" 19","title":"Cell cycle dynamics control fluidity of the developing mouse neuroepithelium","status":"public","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"12837","abstract":[{"text":"As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the physical state of growing tissues are unclear. We found that at early developmental stages, the epithelium in the developing mouse spinal cord maintains both high junctional tension and high fluidity. This is achieved via a mechanism in which interkinetic nuclear movements generate cell area dynamics that drive extensive cell rearrangements. Over time, the cell proliferation rate declines, effectively solidifying the tissue. Thus, unlike well-studied jamming transitions, the solidification uncovered here resembles a glass transition that depends on the dynamical stresses generated by proliferation and differentiation. Our finding that the fluidity of developing epithelia is linked to interkinetic nuclear movements and the dynamics of growth is likely to be relevant to multiple developing tissues.","lang":"eng"}],"type":"journal_article"},{"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"doi":"10.15479/at:ista:13081","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"supervisor":[{"full_name":"Kicheva, Anna","first_name":"Anna","last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4509-4998"}],"degree_awarded":"PhD","publication_identifier":{"issn":["2663 - 337X"]},"month":"05","year":"2023","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"AnKi"}],"publication_status":"published","related_material":{"record":[{"id":"9349","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"12837"}]},"author":[{"first_name":"Laura","last_name":"Bocanegra","id":"4896F754-F248-11E8-B48F-1D18A9856A87","full_name":"Bocanegra, Laura"}],"date_created":"2023-05-23T19:10:42Z","date_updated":"2023-10-04T11:14:04Z","file_date_updated":"2023-05-25T06:32:16Z","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","citation":{"chicago":"Bocanegra, Laura. “Epithelial Dynamics during Mouse Neural Tube Development.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13081.","mla":"Bocanegra, Laura. Epithelial Dynamics during Mouse Neural Tube Development. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13081.","short":"L. Bocanegra, Epithelial Dynamics during Mouse Neural Tube Development, Institute of Science and Technology Austria, 2023.","ista":"Bocanegra L. 2023. Epithelial dynamics during mouse neural tube development. Institute of Science and Technology Austria.","ieee":"L. Bocanegra, “Epithelial dynamics during mouse neural tube development,” Institute of Science and Technology Austria, 2023.","apa":"Bocanegra, L. (2023). Epithelial dynamics during mouse neural tube development. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13081","ama":"Bocanegra L. Epithelial dynamics during mouse neural tube development. 2023. doi:10.15479/at:ista:13081"},"page":"93","date_published":"2023-05-23T00:00:00Z","article_processing_charge":"No","has_accepted_license":"1","day":"23","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"13081","status":"public","title":"Epithelial dynamics during mouse neural tube development","ddc":["570"],"oa_version":"Published Version","file":[{"access_level":"closed","file_name":"Thesis_final_LauraBocanegra.docx","creator":"lbocaneg","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":25615534,"file_id":"13089","relation":"source_file","checksum":"74f3f89e59a0189bee53ebfad9c1b9af","date_updated":"2023-05-25T06:32:12Z","date_created":"2023-05-25T06:32:12Z"},{"relation":"main_file","file_id":"13090","embargo":"2024-05-31","date_created":"2023-05-25T06:32:16Z","date_updated":"2023-05-25T06:32:16Z","checksum":"c6cdef6323eacfb4b7a8af20f32eae97","embargo_to":"open_access","file_name":"TotalFinal_Thesis_LauraBocanegraArx.pdf","access_level":"closed","file_size":12386046,"content_type":"application/pdf","creator":"lbocaneg"}],"type":"dissertation","alternative_title":["ISTA Thesis"],"abstract":[{"text":"During development, tissues undergo changes in size and shape to form functional organs. Distinct cellular processes such as cell division and cell rearrangements underlie tissue morphogenesis. Yet how the distinct processes are controlled and coordinated, and how they contribute to morphogenesis is poorly understood. In our study, we addressed these questions using the developing mouse neural tube. This epithelial organ transforms from a flat epithelial sheet to an epithelial tube while increasing in size and undergoing morpho-gen-mediated patterning. The extent and mechanism of neural progenitor rearrangement within the developing mouse neuroepithelium is unknown. To investigate this, we per-formed high resolution lineage tracing analysis to quantify the extent of epithelial rear-rangement at different stages of neural tube development. We quantitatively described the relationship between apical cell size with cell cycle dependent interkinetic nuclear migra-tions (IKNM) and performed high cellular resolution live imaging of the neuroepithelium to study the dynamics of junctional remodeling. Furthermore, developed a vertex model of the neuroepithelium to investigate the quantitative contribution of cell proliferation, cell differentiation and mechanical properties to the epithelial rearrangement dynamics and validated the model predictions through functional experiments. Our analysis revealed that at early developmental stages, the apical cell area kinetics driven by IKNM induce high lev-els of cell rearrangements in a regime of high junctional tension and contractility. After E9.5, there is a sharp decline in the extent of cell rearrangements, suggesting that the epi-thelium transitions from a fluid-like to a solid-like state. We found that this transition is regulated by the growth rate of the tissue, rather than by changes in cell-cell adhesion and contractile forces. Overall, our study provides a quantitative description of the relationship between tissue growth, cell cycle dynamics, epithelia rearrangements and the emergent tissue material properties, and novel insights on how epithelial cell dynamics influences tissue morphogenesis.","lang":"eng"}]},{"doi":"10.1007/s11356-023-26844-2","language":[{"iso":"eng"}],"external_id":{"pmid":["37055686"],"isi":["000970917900012"]},"quality_controlled":"1","isi":1,"publication_identifier":{"issn":["0944-1344"],"eissn":["1614-7499"]},"month":"05","author":[{"full_name":"Filipović Marijić, Vlatka","first_name":"Vlatka","last_name":"Filipović Marijić"},{"full_name":"Krasnici, Nesrete","first_name":"Nesrete","last_name":"Krasnici","id":"cb5852d4-287f-11ed-baf0-bc1dd2d5c745"},{"last_name":"Valić","first_name":"Damir","full_name":"Valić, Damir"},{"full_name":"Kapetanović, Damir","last_name":"Kapetanović","first_name":"Damir"},{"full_name":"Vardić Smrzlić, Irena","first_name":"Irena","last_name":"Vardić Smrzlić"},{"full_name":"Jordanova, Maja","first_name":"Maja","last_name":"Jordanova"},{"first_name":"Katerina","last_name":"Rebok","full_name":"Rebok, Katerina"},{"last_name":"Ramani","first_name":"Sheriban","full_name":"Ramani, Sheriban"},{"full_name":"Kostov, Vasil","last_name":"Kostov","first_name":"Vasil"},{"full_name":"Nastova, Rodne","last_name":"Nastova","first_name":"Rodne"},{"last_name":"Dragun","first_name":"Zrinka","full_name":"Dragun, Zrinka"}],"volume":30,"date_updated":"2023-10-04T11:23:10Z","date_created":"2023-04-23T22:01:03Z","pmid":1,"year":"2023","acknowledgement":"The authors are grateful to Dr. Nevenka Mikac for the opportunity to perform metal measurements on HR ICP-MS. This research was funded by the Ministry of Science, Education and Sport of the Republic of Croatia (projects No. 098–0982934-2721 and 098–1782739-2749). The sampling was carried out as a part of two Croatian-Macedonian bilateral projects: “The assessment of availability and effects of metals on fish in the rivers under the impact of mining activities” and “Bacterial and parasitical communities of chub as indicators of the status of environment exposed to mining activities.”","department":[{"_id":"LifeSc"}],"publisher":"Springer Nature","publication_status":"published","date_published":"2023-05-01T00:00:00Z","citation":{"ieee":"V. Filipović Marijić et al., “Pollution impact on metal and biomarker responses in intestinal cytosol of freshwater fish,” Environmental Science and Pollution Research, vol. 30. Springer Nature, pp. 63510–63521, 2023.","apa":"Filipović Marijić, V., Krasnici, N., Valić, D., Kapetanović, D., Vardić Smrzlić, I., Jordanova, M., … Dragun, Z. (2023). Pollution impact on metal and biomarker responses in intestinal cytosol of freshwater fish. Environmental Science and Pollution Research. Springer Nature. https://doi.org/10.1007/s11356-023-26844-2","ista":"Filipović Marijić V, Krasnici N, Valić D, Kapetanović D, Vardić Smrzlić I, Jordanova M, Rebok K, Ramani S, Kostov V, Nastova R, Dragun Z. 2023. Pollution impact on metal and biomarker responses in intestinal cytosol of freshwater fish. Environmental Science and Pollution Research. 30, 63510–63521.","ama":"Filipović Marijić V, Krasnici N, Valić D, et al. Pollution impact on metal and biomarker responses in intestinal cytosol of freshwater fish. Environmental Science and Pollution Research. 2023;30:63510-63521. doi:10.1007/s11356-023-26844-2","chicago":"Filipović Marijić, Vlatka, Nesrete Krasnici, Damir Valić, Damir Kapetanović, Irena Vardić Smrzlić, Maja Jordanova, Katerina Rebok, et al. “Pollution Impact on Metal and Biomarker Responses in Intestinal Cytosol of Freshwater Fish.” Environmental Science and Pollution Research. Springer Nature, 2023. https://doi.org/10.1007/s11356-023-26844-2.","short":"V. Filipović Marijić, N. Krasnici, D. Valić, D. Kapetanović, I. Vardić Smrzlić, M. Jordanova, K. Rebok, S. Ramani, V. Kostov, R. Nastova, Z. Dragun, Environmental Science and Pollution Research 30 (2023) 63510–63521.","mla":"Filipović Marijić, Vlatka, et al. “Pollution Impact on Metal and Biomarker Responses in Intestinal Cytosol of Freshwater Fish.” Environmental Science and Pollution Research, vol. 30, Springer Nature, 2023, pp. 63510–21, doi:10.1007/s11356-023-26844-2."},"publication":"Environmental Science and Pollution Research","page":"63510-63521","article_type":"original","article_processing_charge":"No","day":"01","scopus_import":"1","oa_version":"None","_id":"12863","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 30","title":"Pollution impact on metal and biomarker responses in intestinal cytosol of freshwater fish","status":"public","abstract":[{"lang":"eng","text":"In the present study, essential and nonessential metal content and biomarker responses were investigated in the intestine of fish collected from the areas polluted by mining. Our objective was to determine metal and biomarker levels in tissue responsible for dietary intake, which is rarely studied in water pollution research. The study was conducted in the Bregalnica River, reference location, and in the Zletovska and Kriva Rivers (the Republic of North Macedonia), which are directly influenced by the active mines Zletovo and Toranica, respectively. Biological responses were analyzed in Vardar chub (Squalius vardarensis; Karaman, 1928), using for the first time intestinal cytosol as a potentially toxic cell fraction, since metal sensitivity is mostly associated with cytosol. Cytosolic metal levels were higher in fish under the influence of mining (Tl, Li, Cs, Mo, Sr, Cd, Rb, and Cu in the Zletovska River and Cr, Pb, and Se in the Kriva River compared to the Bregalnica River in both seasons). The same trend was evident for total proteins, biomarkers of general stress, and metallothioneins, biomarkers of metal exposure, indicating cellular disturbances in the intestine, the primary site of dietary metal uptake. The association of cytosolic Cu and Cd at all locations pointed to similar pathways and homeostasis of these metallothionein-binding metals. Comparison with other indicator tissues showed that metal concentrations were higher in the intestine of fish from mining-affected areas than in the liver and gills. In general, these results indicated the importance of dietary metal pathways, and cytosolic metal fraction in assessing pollution impacts in freshwater ecosystems."}],"type":"journal_article"}]