[{"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Laurent P, Ch’ng Q, Jospin M, Chen C, Lorenzo R, de Bono M. Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron. Proceedings of the National Academy of Sciences. 2018;115(29):E6890-E6899. doi:10.1073/pnas.1714610115","apa":"Laurent, P., Ch’ng, Q., Jospin, M., Chen, C., Lorenzo, R., & de Bono, M. (2018). Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.1714610115","ieee":"P. Laurent, Q. Ch’ng, M. Jospin, C. Chen, R. Lorenzo, and M. de Bono, “Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron,” Proceedings of the National Academy of Sciences, vol. 115, no. 29. National Academy of Sciences, pp. E6890–E6899, 2018.","short":"P. Laurent, Q. Ch’ng, M. Jospin, C. Chen, R. Lorenzo, M. de Bono, Proceedings of the National Academy of Sciences 115 (2018) E6890–E6899.","mla":"Laurent, Patrick, et al. “Genetic Dissection of Neuropeptide Cell Biology at High and Low Activity in a Defined Sensory Neuron.” Proceedings of the National Academy of Sciences, vol. 115, no. 29, National Academy of Sciences, 2018, pp. E6890–99, doi:10.1073/pnas.1714610115.","ista":"Laurent P, Ch’ng Q, Jospin M, Chen C, Lorenzo R, de Bono M. 2018. Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron. Proceedings of the National Academy of Sciences. 115(29), E6890–E6899.","chicago":"Laurent, Patrick, QueeLim Ch’ng, Maëlle Jospin, Changchun Chen, Ramiro Lorenzo, and Mario de Bono. “Genetic Dissection of Neuropeptide Cell Biology at High and Low Activity in a Defined Sensory Neuron.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2018. https://doi.org/10.1073/pnas.1714610115."},"title":"Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron","author":[{"first_name":"Patrick","full_name":"Laurent, Patrick","last_name":"Laurent"},{"full_name":"Ch’ng, QueeLim","last_name":"Ch’ng","first_name":"QueeLim"},{"first_name":"Maëlle","full_name":"Jospin, Maëlle","last_name":"Jospin"},{"last_name":"Chen","full_name":"Chen, Changchun","first_name":"Changchun"},{"first_name":"Ramiro","last_name":"Lorenzo","full_name":"Lorenzo, Ramiro"},{"orcid":"0000-0001-8347-0443","full_name":"de Bono, Mario","last_name":"de Bono","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","first_name":"Mario"}],"external_id":{"pmid":["29959203"]},"day":"17","publication":"Proceedings of the National Academy of Sciences","has_accepted_license":"1","year":"2018","date_published":"2018-07-17T00:00:00Z","doi":"10.1073/pnas.1714610115","date_created":"2019-03-19T12:41:33Z","page":"E6890-E6899","publisher":"National Academy of Sciences","quality_controlled":"1","oa":1,"extern":"1","ddc":["570"],"date_updated":"2021-01-12T08:06:09Z","file_date_updated":"2020-07-14T12:47:19Z","_id":"6109","status":"public","type":"journal_article","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"file":[{"creator":"kschuh","date_updated":"2020-07-14T12:47:19Z","file_size":1567765,"date_created":"2019-03-19T13:01:58Z","file_name":"2018_PNAS_Laurent.pdf","access_level":"open_access","relation":"main_file","content_type":"application/pdf","checksum":"5e81665377441cdd8d99ab952c534319","file_id":"6110"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0027-8424","1091-6490"]},"publication_status":"published","issue":"29","volume":115,"oa_version":"Published Version","pmid":1,"abstract":[{"text":"Neuropeptides are ubiquitous modulators of behavior and physiology. They are packaged in specialized secretory organelles called dense core vesicles (DCVs) that are released upon neural stimulation. Unlike synaptic vesicles, which can be recycled and refilled close to release sites, DCVs must be replenished by de novo synthesis in the cell body. Here, we dissect DCV cell biology in vivo in a Caenorhabditis elegans sensory neuron whose tonic activity we can control using a natural stimulus. We express fluorescently tagged neuropeptides in the neuron and define parameters that describe their subcellular distribution. We measure these parameters at high and low neural activity in 187 mutants defective in proteins implicated in membrane traffic, neuroendocrine secretion, and neuronal or synaptic activity. Using unsupervised hierarchical clustering methods, we analyze these data and identify 62 groups of genes with similar mutant phenotypes. We explore the function of a subset of these groups. We recapitulate many previous findings, validating our paradigm. We uncover a large battery of proteins involved in recycling DCV membrane proteins, something hitherto poorly explored. We show that the unfolded protein response promotes DCV production, which may contribute to intertissue communication of stress. We also find evidence that different mechanisms of priming and exocytosis may operate at high and low neural activity. Our work provides a defined framework to study DCV biology at different neural activity levels.","lang":"eng"}],"month":"07","intvolume":" 115"},{"extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_updated":"2022-01-27T15:26:39Z","citation":{"chicago":"Koshti, Girish, Ranita Biswas, Gaëlle Largeteau-Skapin, Rita Zrour, Eric Andres, and Partha Bhowmick. “Sphere Construction on the FCC Grid Interpreted as Layered Hexagonal Grids in 3D.” In 19th International Workshop, 11255:82–96. Cham: Springer, 2018. https://doi.org/10.1007/978-3-030-05288-1_7.","ista":"Koshti G, Biswas R, Largeteau-Skapin G, Zrour R, Andres E, Bhowmick P. 2018. Sphere construction on the FCC grid interpreted as layered hexagonal grids in 3D. 19th International Workshop. IWCIA: International Workshop on Combinatorial Image Analysis, LNCS, vol. 11255, 82–96.","mla":"Koshti, Girish, et al. “Sphere Construction on the FCC Grid Interpreted as Layered Hexagonal Grids in 3D.” 19th International Workshop, vol. 11255, Springer, 2018, pp. 82–96, doi:10.1007/978-3-030-05288-1_7.","ama":"Koshti G, Biswas R, Largeteau-Skapin G, Zrour R, Andres E, Bhowmick P. Sphere construction on the FCC grid interpreted as layered hexagonal grids in 3D. In: 19th International Workshop. Vol 11255. Cham: Springer; 2018:82-96. doi:10.1007/978-3-030-05288-1_7","apa":"Koshti, G., Biswas, R., Largeteau-Skapin, G., Zrour, R., Andres, E., & Bhowmick, P. (2018). Sphere construction on the FCC grid interpreted as layered hexagonal grids in 3D. In 19th International Workshop (Vol. 11255, pp. 82–96). Cham: Springer. https://doi.org/10.1007/978-3-030-05288-1_7","ieee":"G. Koshti, R. Biswas, G. Largeteau-Skapin, R. Zrour, E. Andres, and P. Bhowmick, “Sphere construction on the FCC grid interpreted as layered hexagonal grids in 3D,” in 19th International Workshop, Porto, Portugal, 2018, vol. 11255, pp. 82–96.","short":"G. Koshti, R. Biswas, G. Largeteau-Skapin, R. Zrour, E. Andres, P. Bhowmick, in:, 19th International Workshop, Springer, Cham, 2018, pp. 82–96."},"title":"Sphere construction on the FCC grid interpreted as layered hexagonal grids in 3D","author":[{"last_name":"Koshti","full_name":"Koshti, Girish","first_name":"Girish"},{"orcid":"0000-0002-5372-7890","full_name":"Biswas, Ranita","last_name":"Biswas","id":"3C2B033E-F248-11E8-B48F-1D18A9856A87","first_name":"Ranita"},{"first_name":"Gaëlle","last_name":"Largeteau-Skapin","full_name":"Largeteau-Skapin, Gaëlle"},{"full_name":"Zrour, Rita","last_name":"Zrour","first_name":"Rita"},{"first_name":"Eric","last_name":"Andres","full_name":"Andres, Eric"},{"full_name":"Bhowmick, Partha","last_name":"Bhowmick","first_name":"Partha"}],"article_processing_charge":"No","_id":"6164","status":"public","type":"conference","conference":{"name":"IWCIA: International Workshop on Combinatorial Image Analysis","start_date":"2018-11-22","end_date":"2018-11-24","location":"Porto, Portugal"},"day":"22","publication":"19th International Workshop","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["978-3-030-05287-4"],"eissn":["1611-3349"],"issn":["0302-9743"],"eisbn":["978-3-030-05288-1"]},"publication_status":"published","year":"2018","volume":11255,"date_published":"2018-11-22T00:00:00Z","doi":"10.1007/978-3-030-05288-1_7","date_created":"2019-03-21T12:16:58Z","page":"82-96","oa_version":"None","abstract":[{"lang":"eng","text":"In this paper, we propose an algorithm to build discrete spherical shell having integer center and real-valued inner and outer radii on the face-centered cubic (FCC) grid. We address the problem by mapping it to a 2D scenario and building the shell layer by layer on hexagonal grids with additive manufacturing in mind. The layered hexagonal grids get shifted according to need as we move from one layer to another and forms the FCC grid in 3D. However, we restrict our computation strictly to 2D in order to utilize symmetry and simplicity."}],"month":"11","place":"Cham","intvolume":" 11255","publisher":"Springer","alternative_title":["LNCS"],"quality_controlled":"1"},{"_id":"6354","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","keyword":["Platelets","Cell migration","Bacteria","Shear flow","Fibrinogen","E. coli"],"status":"public","date_updated":"2021-01-12T08:07:12Z","ddc":["570"],"department":[{"_id":"MiSi"}],"file_date_updated":"2020-07-14T12:47:28Z","abstract":[{"text":"Blood platelets are critical for hemostasis and thrombosis, but also play diverse roles during immune responses. We have recently reported that platelets migrate at sites of infection in vitro and in vivo. Importantly, platelets use their ability to migrate to collect and bundle fibrin (ogen)-bound bacteria accomplishing efficient intravascular bacterial trapping. Here, we describe a method that allows analyzing platelet migration in vitro, focusing on their ability to collect bacteria and trap bacteria under flow.","lang":"eng"}],"oa_version":"Published Version","intvolume":" 8","month":"09","publication_status":"published","publication_identifier":{"issn":["2331-8325"]},"language":[{"iso":"eng"}],"file":[{"date_created":"2019-04-30T08:04:33Z","file_name":"2018_BioProtocol_Fan.pdf","creator":"dernst","date_updated":"2020-07-14T12:47:28Z","file_size":2928337,"file_id":"6360","checksum":"d4588377e789da7f360b553ae02c5119","access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"ec_funded":1,"volume":8,"issue":"18","article_number":"e3018","project":[{"grant_number":"747687","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","_id":"260AA4E2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"citation":{"mla":"Fan, Shuxia, et al. “Platelet Migration and Bacterial Trapping Assay under Flow.” Bio-Protocol, vol. 8, no. 18, e3018, Bio-Protocol, 2018, doi:10.21769/bioprotoc.3018.","short":"S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).","ieee":"S. Fan, M. Lorenz, S. Massberg, and F. R. Gärtner, “Platelet migration and bacterial trapping assay under flow,” Bio-Protocol, vol. 8, no. 18. Bio-Protocol, 2018.","ama":"Fan S, Lorenz M, Massberg S, Gärtner FR. Platelet migration and bacterial trapping assay under flow. Bio-Protocol. 2018;8(18). doi:10.21769/bioprotoc.3018","apa":"Fan, S., Lorenz, M., Massberg, S., & Gärtner, F. R. (2018). Platelet migration and bacterial trapping assay under flow. Bio-Protocol. Bio-Protocol. https://doi.org/10.21769/bioprotoc.3018","chicago":"Fan, Shuxia, Michael Lorenz, Steffen Massberg, and Florian R Gärtner. “Platelet Migration and Bacterial Trapping Assay under Flow.” Bio-Protocol. Bio-Protocol, 2018. https://doi.org/10.21769/bioprotoc.3018.","ista":"Fan S, Lorenz M, Massberg S, Gärtner FR. 2018. Platelet migration and bacterial trapping assay under flow. Bio-Protocol. 8(18), e3018."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Shuxia","last_name":"Fan","full_name":"Fan, Shuxia"},{"first_name":"Michael","last_name":"Lorenz","full_name":"Lorenz, Michael"},{"first_name":"Steffen","full_name":"Massberg, Steffen","last_name":"Massberg"},{"full_name":"Gärtner, Florian R","orcid":"0000-0001-6120-3723","last_name":"Gärtner","first_name":"Florian R","id":"397A88EE-F248-11E8-B48F-1D18A9856A87"}],"title":"Platelet migration and bacterial trapping assay under flow","acknowledgement":" FöFoLe project 947 (F.G.), the Friedrich-Baur-Stiftung project 41/16 (F.G.)","oa":1,"publisher":"Bio-Protocol","quality_controlled":"1","year":"2018","has_accepted_license":"1","publication":"Bio-Protocol","day":"20","date_created":"2019-04-29T09:40:33Z","doi":"10.21769/bioprotoc.3018","date_published":"2018-09-20T00:00:00Z"},{"date_created":"2019-05-03T09:17:20Z","issue":"10","volume":14,"doi":"10.1038/s41567-018-0210-0","date_published":"2018-10-01T00:00:00Z","page":"1038-1042","publication":"Nature Physics","language":[{"iso":"eng"}],"day":"01","publication_status":"published","year":"2018","publication_identifier":{"issn":["1745-2473","1745-2481"]},"intvolume":" 14","month":"10","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1712.06535"}],"oa":1,"quality_controlled":"1","publisher":"Springer Nature","oa_version":"Preprint","abstract":[{"text":"An optical network of superconducting quantum bits (qubits) is an appealing platform for quantum communication and distributed quantum computing, but developing a quantum-compatible link between the microwave and optical domains remains an outstanding challenge. Operating at T < 100 mK temperatures, as required for quantum electrical circuits, we demonstrate a mechanically mediated microwave–optical converter with 47% conversion efficiency, and use a classical feed-forward protocol to reduce added noise to 38 photons. The feed-forward protocol harnesses our discovery that noise emitted from the two converter output ports is strongly correlated because both outputs record thermal motion of the same mechanical mode. We also discuss a quantum feed-forward protocol that, given high system efficiencies, would allow quantum information to be transferred even when thermal phonons enter the mechanical element faster than the electro-optic conversion rate.","lang":"eng"}],"title":"Harnessing electro-optic correlations in an efficient mechanical converter","external_id":{"arxiv":["1712.06535"]},"author":[{"last_name":"Higginbotham","full_name":"Higginbotham, Andrew P","orcid":"0000-0003-2607-2363","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","first_name":"Andrew P"},{"first_name":"P. S.","full_name":"Burns, P. S.","last_name":"Burns"},{"last_name":"Urmey","full_name":"Urmey, M. D.","first_name":"M. D."},{"last_name":"Peterson","full_name":"Peterson, R. W.","first_name":"R. W."},{"first_name":"N. S.","full_name":"Kampel, N. S.","last_name":"Kampel"},{"first_name":"B. M.","last_name":"Brubaker","full_name":"Brubaker, B. M."},{"first_name":"G.","full_name":"Smith, G.","last_name":"Smith"},{"full_name":"Lehnert, K. W.","last_name":"Lehnert","first_name":"K. W."},{"full_name":"Regal, C. A.","last_name":"Regal","first_name":"C. A."}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2021-01-12T08:07:15Z","citation":{"chicago":"Higginbotham, Andrew P, P. S. Burns, M. D. Urmey, R. W. Peterson, N. S. Kampel, B. M. Brubaker, G. Smith, K. W. Lehnert, and C. A. Regal. “Harnessing Electro-Optic Correlations in an Efficient Mechanical Converter.” Nature Physics. Springer Nature, 2018. https://doi.org/10.1038/s41567-018-0210-0.","ista":"Higginbotham AP, Burns PS, Urmey MD, Peterson RW, Kampel NS, Brubaker BM, Smith G, Lehnert KW, Regal CA. 2018. Harnessing electro-optic correlations in an efficient mechanical converter. Nature Physics. 14(10), 1038–1042.","mla":"Higginbotham, Andrew P., et al. “Harnessing Electro-Optic Correlations in an Efficient Mechanical Converter.” Nature Physics, vol. 14, no. 10, Springer Nature, 2018, pp. 1038–42, doi:10.1038/s41567-018-0210-0.","ama":"Higginbotham AP, Burns PS, Urmey MD, et al. Harnessing electro-optic correlations in an efficient mechanical converter. Nature Physics. 2018;14(10):1038-1042. doi:10.1038/s41567-018-0210-0","apa":"Higginbotham, A. P., Burns, P. S., Urmey, M. D., Peterson, R. W., Kampel, N. S., Brubaker, B. M., … Regal, C. A. (2018). Harnessing electro-optic correlations in an efficient mechanical converter. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-018-0210-0","ieee":"A. P. Higginbotham et al., “Harnessing electro-optic correlations in an efficient mechanical converter,” Nature Physics, vol. 14, no. 10. Springer Nature, pp. 1038–1042, 2018.","short":"A.P. Higginbotham, P.S. Burns, M.D. Urmey, R.W. Peterson, N.S. Kampel, B.M. Brubaker, G. Smith, K.W. Lehnert, C.A. Regal, Nature Physics 14 (2018) 1038–1042."},"status":"public","type":"journal_article","_id":"6368"},{"date_created":"2019-05-03T09:29:49Z","date_published":"2018-06-04T00:00:00Z","issue":"22","doi":"10.1103/physrevb.97.220301","volume":97,"publication_status":"published","year":"2018","publication_identifier":{"issn":["2469-9950","2469-9969"]},"publication":"Physical Review B","language":[{"iso":"eng"}],"day":"04","main_file_link":[{"url":"https://arxiv.org/abs/1802.02243","open_access":"1"}],"oa":1,"quality_controlled":"1","publisher":"American Physical Society (APS)","intvolume":" 97","month":"06","abstract":[{"text":"We construct a metamaterial from radio-frequency harmonic oscillators, and find two topologically distinct phases resulting from dissipation engineered into the system. These phases are distinguished by a quantized value of bulk energy transport. The impulse response of our circuit is measured and used to reconstruct the band structure and winding number of circuit eigenfunctions around a dark mode. Our results demonstrate that dissipative topological transport can occur in a wider class of physical systems than considered before.","lang":"eng"}],"oa_version":"Preprint","external_id":{"arxiv":["1802.02243"]},"author":[{"last_name":"Rosenthal","full_name":"Rosenthal, Eric I.","first_name":"Eric I."},{"first_name":"Nicole K.","full_name":"Ehrlich, Nicole K.","last_name":"Ehrlich"},{"last_name":"Rudner","full_name":"Rudner, Mark S.","first_name":"Mark S."},{"orcid":"0000-0003-2607-2363","full_name":"Higginbotham, Andrew P","last_name":"Higginbotham","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","first_name":"Andrew P"},{"first_name":"K. W.","full_name":"Lehnert, K. W.","last_name":"Lehnert"}],"title":"Topological phase transition measured in a dissipative metamaterial","citation":{"chicago":"Rosenthal, Eric I., Nicole K. Ehrlich, Mark S. Rudner, Andrew P Higginbotham, and K. W. Lehnert. “Topological Phase Transition Measured in a Dissipative Metamaterial.” Physical Review B. American Physical Society (APS), 2018. https://doi.org/10.1103/physrevb.97.220301.","ista":"Rosenthal EI, Ehrlich NK, Rudner MS, Higginbotham AP, Lehnert KW. 2018. Topological phase transition measured in a dissipative metamaterial. Physical Review B. 97(22), 220301.","mla":"Rosenthal, Eric I., et al. “Topological Phase Transition Measured in a Dissipative Metamaterial.” Physical Review B, vol. 97, no. 22, 220301, American Physical Society (APS), 2018, doi:10.1103/physrevb.97.220301.","short":"E.I. Rosenthal, N.K. Ehrlich, M.S. Rudner, A.P. Higginbotham, K.W. Lehnert, Physical Review B 97 (2018).","ieee":"E. I. Rosenthal, N. K. Ehrlich, M. S. Rudner, A. P. Higginbotham, and K. W. Lehnert, “Topological phase transition measured in a dissipative metamaterial,” Physical Review B, vol. 97, no. 22. American Physical Society (APS), 2018.","apa":"Rosenthal, E. I., Ehrlich, N. K., Rudner, M. S., Higginbotham, A. P., & Lehnert, K. W. (2018). Topological phase transition measured in a dissipative metamaterial. Physical Review B. American Physical Society (APS). https://doi.org/10.1103/physrevb.97.220301","ama":"Rosenthal EI, Ehrlich NK, Rudner MS, Higginbotham AP, Lehnert KW. Topological phase transition measured in a dissipative metamaterial. Physical Review B. 2018;97(22). doi:10.1103/physrevb.97.220301"},"date_updated":"2021-01-12T08:07:16Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","extern":"1","type":"journal_article","status":"public","_id":"6369","article_number":"220301"}]