[{"type":"research_data","abstract":[{"lang":"eng","text":"Here are the research data underlying the publication \"Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)\". Further information are summed up in the README document.\r\nThe files for this record have been updated and are now found in the linked DOI https://doi.org/10.15479/AT:ISTA:9192."}],"file_date_updated":"2020-08-18T08:03:23Z","license":"https://creativecommons.org/licenses/by/4.0/","year":"2020","_id":"8254","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Institute of Science and Technology Austria","department":[{"_id":"NiBa"}],"title":"Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)","ddc":["576"],"status":"public","related_material":{"record":[{"id":"11321","status":"public","relation":"later_version"},{"id":"9192","status":"public","relation":"later_version"}]},"contributor":[{"contributor_type":"data_collector","last_name":"Arathoon","first_name":"Louise S","id":"2CFCFF98-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Parvathy","contributor_type":"project_member","last_name":"Surendranadh","id":"455235B8-F248-11E8-B48F-1D18A9856A87"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","contributor_type":"project_member","last_name":"Barton"},{"first_name":"David","contributor_type":"project_member","last_name":"Field","id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478"},{"first_name":"Melinda","contributor_type":"project_member","last_name":"Pickup","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6118-0541"},{"contributor_type":"project_member","last_name":"Baskett","first_name":"Carina","id":"3B4A7CE2-F248-11E8-B48F-1D18A9856A87"}],"author":[{"last_name":"Arathoon","first_name":"Louise S","orcid":"0000-0003-1771-714X","id":"2CFCFF98-F248-11E8-B48F-1D18A9856A87","full_name":"Arathoon, Louise S"}],"oa_version":"Published Version","file":[{"date_updated":"2020-08-18T08:03:23Z","date_created":"2020-08-18T08:03:23Z","checksum":"4f1382ed4384751b6013398c11557bf6","success":1,"relation":"main_file","file_id":"8280","file_size":5778420,"content_type":"application/x-zip-compressed","creator":"dernst","file_name":"Data_Rcode_MathematicaNB.zip","access_level":"open_access"}],"date_updated":"2024-02-21T12:41:09Z","date_created":"2020-08-12T12:49:23Z","has_accepted_license":"1","article_processing_charge":"No","day":"18","month":"08","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"citation":{"short":"L.S. Arathoon, (2020).","mla":"Arathoon, Louise S. Estimating Inbreeding and Its Effects in a Long-Term Study of Snapdragons (Antirrhinum Majus). Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8254.","chicago":"Arathoon, Louise S. “Estimating Inbreeding and Its Effects in a Long-Term Study of Snapdragons (Antirrhinum Majus).” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8254.","ama":"Arathoon LS. Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus). 2020. doi:10.15479/AT:ISTA:8254","ieee":"L. S. Arathoon, “Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus).” Institute of Science and Technology Austria, 2020.","apa":"Arathoon, L. S. (2020). Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus). Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8254","ista":"Arathoon LS. 2020. Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus), Institute of Science and Technology Austria, 10.15479/AT:ISTA:8254."},"oa":1,"doi":"10.15479/AT:ISTA:8254","date_published":"2020-08-18T00:00:00Z"},{"file":[{"relation":"main_file","file_id":"8782","date_created":"2020-11-20T10:11:35Z","date_updated":"2020-11-20T10:11:35Z","checksum":"c622737dc295972065782558337124a2","success":1,"file_name":"2020_AdvancedMaterials_Gao.pdf","access_level":"open_access","content_type":"application/pdf","file_size":5242880,"creator":"dernst"}],"oa_version":"Published Version","intvolume":" 32","status":"public","ddc":["530"],"title":"Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling","_id":"7541","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"16","abstract":[{"text":"Semiconductor nanowires have been playing a crucial role in the development of nanoscale devices for the realization of spin qubits, Majorana fermions, single photon emitters, nanoprocessors, etc. The monolithic growth of site‐controlled nanowires is a prerequisite toward the next generation of devices that will require addressability and scalability. Here, combining top‐down nanofabrication and bottom‐up self‐assembly, the growth of Ge wires on prepatterned Si (001) substrates with controllable position, distance, length, and structure is reported. This is achieved by a novel growth process that uses a SiGe strain‐relaxation template and can be potentially generalized to other material combinations. Transport measurements show an electrically tunable spin–orbit coupling, with a spin–orbit length similar to that of III–V materials. Also, charge sensing between quantum dots in closely spaced wires is observed, which underlines their potential for the realization of advanced quantum devices. The reported results open a path toward scalable qubit devices using nanowires on silicon.","lang":"eng"}],"type":"journal_article","date_published":"2020-04-23T00:00:00Z","article_type":"original","citation":{"chicago":"Gao, Fei, Jian-Huan Wang, Hannes Watzinger, Hao Hu, Marko J. Rančić, Jie-Yin Zhang, Ting Wang, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically Tunable Spin-Orbit Coupling.” Advanced Materials. Wiley, 2020. https://doi.org/10.1002/adma.201906523.","short":"F. Gao, J.-H. Wang, H. Watzinger, H. Hu, M.J. Rančić, J.-Y. Zhang, T. Wang, Y. Yao, G.-L. Wang, J. Kukucka, L. Vukušić, C. Kloeffel, D. Loss, F. Liu, G. Katsaros, J.-J. Zhang, Advanced Materials 32 (2020).","mla":"Gao, Fei, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically Tunable Spin-Orbit Coupling.” Advanced Materials, vol. 32, no. 16, 1906523, Wiley, 2020, doi:10.1002/adma.201906523.","apa":"Gao, F., Wang, J.-H., Watzinger, H., Hu, H., Rančić, M. J., Zhang, J.-Y., … Zhang, J.-J. (2020). Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling. Advanced Materials. Wiley. https://doi.org/10.1002/adma.201906523","ieee":"F. Gao et al., “Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling,” Advanced Materials, vol. 32, no. 16. Wiley, 2020.","ista":"Gao F, Wang J-H, Watzinger H, Hu H, Rančić MJ, Zhang J-Y, Wang T, Yao Y, Wang G-L, Kukucka J, Vukušić L, Kloeffel C, Loss D, Liu F, Katsaros G, Zhang J-J. 2020. Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling. Advanced Materials. 32(16), 1906523.","ama":"Gao F, Wang J-H, Watzinger H, et al. Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling. Advanced Materials. 2020;32(16). doi:10.1002/adma.201906523"},"publication":"Advanced Materials","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","day":"23","scopus_import":"1","volume":32,"date_created":"2020-02-28T09:47:00Z","date_updated":"2024-02-21T12:42:12Z","related_material":{"record":[{"id":"7996","relation":"dissertation_contains","status":"public"},{"relation":"research_data","status":"public","id":"9222"}]},"author":[{"full_name":"Gao, Fei","last_name":"Gao","first_name":"Fei"},{"first_name":"Jian-Huan","last_name":"Wang","full_name":"Wang, Jian-Huan"},{"full_name":"Watzinger, Hannes","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87","first_name":"Hannes","last_name":"Watzinger"},{"first_name":"Hao","last_name":"Hu","full_name":"Hu, Hao"},{"first_name":"Marko J.","last_name":"Rančić","full_name":"Rančić, Marko J."},{"first_name":"Jie-Yin","last_name":"Zhang","full_name":"Zhang, Jie-Yin"},{"full_name":"Wang, Ting","last_name":"Wang","first_name":"Ting"},{"last_name":"Yao","first_name":"Yuan","full_name":"Yao, Yuan"},{"full_name":"Wang, Gui-Lei","first_name":"Gui-Lei","last_name":"Wang"},{"full_name":"Kukucka, Josip","id":"3F5D8856-F248-11E8-B48F-1D18A9856A87","first_name":"Josip","last_name":"Kukucka"},{"last_name":"Vukušić","first_name":"Lada","orcid":"0000-0003-2424-8636","id":"31E9F056-F248-11E8-B48F-1D18A9856A87","full_name":"Vukušić, Lada"},{"full_name":"Kloeffel, Christoph","last_name":"Kloeffel","first_name":"Christoph"},{"full_name":"Loss, Daniel","first_name":"Daniel","last_name":"Loss"},{"first_name":"Feng","last_name":"Liu","full_name":"Liu, Feng"},{"last_name":"Katsaros","first_name":"Georgios","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios"},{"last_name":"Zhang","first_name":"Jian-Jun","full_name":"Zhang, Jian-Jun"}],"department":[{"_id":"GeKa"}],"publisher":"Wiley","publication_status":"published","acknowledgement":"This work was supported by the National Key R&D Program of China (Grant Nos. 2016YFA0301701 and 2016YFA0300600), the NSFC (Grant Nos. 11574356, 11434010, and 11404252), the Strategic Priority Research Program of CAS (Grant No. XDB30000000), the ERC Starting Grant No. 335497, the FWF P32235 project, and the European Union's Horizon 2020 research and innovation program under Grant Agreement #862046. This research was supported by the Scientific Service Units of IST Austria through resources provided by the MIBA Machine Shop and the nanofabrication facility. F.L. thanks support from DOE (Grant No. DE‐FG02‐04ER46148). H.H. thanks the Startup Funding from Xi'an Jiaotong University.","year":"2020","ec_funded":1,"file_date_updated":"2020-11-20T10:11:35Z","article_number":"1906523","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"M-Shop"}],"doi":"10.1002/adma.201906523","project":[{"grant_number":"335497","_id":"25517E86-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires"},{"grant_number":"P32235","_id":"237B3DA4-32DE-11EA-91FC-C7463DDC885E","name":"Towards scalable hut wire quantum devices","call_identifier":"FWF"},{"call_identifier":"H2020","name":"TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS","_id":"237E5020-32DE-11EA-91FC-C7463DDC885E","grant_number":"862046"}],"quality_controlled":"1","isi":1,"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000516660900001"]},"publication_identifier":{"issn":["0935-9648"]},"month":"04"},{"doi":"10.15479/AT:ISTA:8930","date_published":"2020-12-10T00:00:00Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"citation":{"short":"B. Kavcic, (2020).","mla":"Kavcic, Bor. Analysis Scripts and Research Data for the Paper “Minimal Biophysical Model of Combined Antibiotic Action.” Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8930.","chicago":"Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8930.","ama":"Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” 2020. doi:10.15479/AT:ISTA:8930","apa":"Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8930","ieee":"B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action.’” Institute of Science and Technology Austria, 2020.","ista":"Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8930."},"article_processing_charge":"No","has_accepted_license":"1","month":"12","day":"10","keyword":["Escherichia coli","antibiotic combinations","translation","growth laws","drug interactions","bacterial physiology","translation inhibitors"],"contributor":[{"last_name":"Tkačik","contributor_type":"supervisor","first_name":"Gašper","orcid":"0000-0002-6699-1455","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Tobias","contributor_type":"supervisor","last_name":"Bollenbach"}],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"8997"}]},"author":[{"first_name":"Bor","last_name":"Kavcic","id":"350F91D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6041-254X","full_name":"Kavcic, Bor"}],"oa_version":"Published Version","file":[{"file_id":"8932","relation":"main_file","success":1,"checksum":"60a818edeffaa7da1ebf5f8fbea9ba18","date_created":"2020-12-09T15:00:19Z","date_updated":"2020-12-09T15:00:19Z","access_level":"open_access","file_name":"PLoSCompBiol2020_datarep.zip","creator":"bkavcic","file_size":315494370,"content_type":"application/zip"}],"date_updated":"2024-02-21T12:41:42Z","date_created":"2020-12-09T15:04:02Z","year":"2020","_id":"8930","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GaTk"}],"ddc":["570"],"title":"Analysis scripts and research data for the paper \"Minimal biophysical model of combined antibiotic action\"","status":"public","abstract":[{"text":"Phenomenological relations such as Ohm’s or Fourier’s law have a venerable history in physics but are still scarce in biology. This situation restrains predictive theory. Here, we build on bacterial “growth laws,” which capture physiological feedback between translation and cell growth, to construct a minimal biophysical model for the combined action of ribosome-targeting antibiotics. Our model predicts drug interactions like antagonism or synergy solely from responses to individual drugs. We provide analytical results for limiting cases, which agree well with numerical results. We systematically refine the model by including direct physical interactions of different antibiotics on the ribosome. In a limiting case, our model provides a mechanistic underpinning for recent predictions of higher-order interactions that were derived using entropy maximization. We further refine the model to include the effects of antibiotics that mimic starvation and the presence of resistance genes. We describe the impact of a starvation-mimicking antibiotic on drug interactions analytically and verify it experimentally. Our extended model suggests a change in the type of drug interaction that depends on the strength of resistance, which challenges established rescaling paradigms. We experimentally show that the presence of unregulated resistance genes can lead to altered drug interaction, which agrees with the prediction of the model. While minimal, the model is readily adaptable and opens the door to predicting interactions of second and higher-order in a broad range of biological systems.","lang":"eng"}],"file_date_updated":"2020-12-09T15:00:19Z","type":"research_data"},{"has_accepted_license":"1","article_processing_charge":"No","day":"21","month":"12","keyword":["Gene regulatory networks","Gene expression","Escherichia coli","Synthetic Biology"],"doi":"10.15479/AT:ISTA:8951","date_published":"2020-12-21T00:00:00Z","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"citation":{"chicago":"Nagy-Staron, Anna A. “Sequences of Gene Regulatory Network Permutations for the Article ‘Local Genetic Context Shapes the Function of a Gene Regulatory Network.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8951.","mla":"Nagy-Staron, Anna A. Sequences of Gene Regulatory Network Permutations for the Article “Local Genetic Context Shapes the Function of a Gene Regulatory Network.” Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8951.","short":"A.A. Nagy-Staron, (2020).","ista":"Nagy-Staron AA. 2020. Sequences of gene regulatory network permutations for the article ‘Local genetic context shapes the function of a gene regulatory network’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8951.","apa":"Nagy-Staron, A. A. (2020). Sequences of gene regulatory network permutations for the article “Local genetic context shapes the function of a gene regulatory network.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8951","ieee":"A. A. Nagy-Staron, “Sequences of gene regulatory network permutations for the article ‘Local genetic context shapes the function of a gene regulatory network.’” Institute of Science and Technology Austria, 2020.","ama":"Nagy-Staron AA. Sequences of gene regulatory network permutations for the article “Local genetic context shapes the function of a gene regulatory network.” 2020. doi:10.15479/AT:ISTA:8951"},"abstract":[{"text":"Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions, such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networks remains a major challenge. Here, we use a well-defined synthetic gene regulatory network to study how network phenotypes depend on local genetic context, i.e. the genetic neighborhood of a transcription factor and its relative position. We show that one gene regulatory network with fixed topology can display not only quantitatively but also qualitatively different phenotypes, depending solely on the local genetic context of its components. Our results demonstrate that changes in local genetic context can place a single transcriptional unit within two separate regulons without the need for complex regulatory sequences. We propose that relative order of individual transcriptional units, with its potential for combinatorial complexity, plays an important role in shaping phenotypes of gene regulatory networks.","lang":"eng"}],"file_date_updated":"2020-12-20T22:01:44Z","type":"research_data","related_material":{"record":[{"id":"9283","status":"public","relation":"used_in_publication"}]},"contributor":[{"contributor_type":"project_member","last_name":"Nagy-Staron","first_name":"Anna A","id":"3ABC5BA6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Tomasek","contributor_type":"project_member","first_name":"Kathrin","id":"3AEC8556-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Caroline","last_name":"Caruso Carter","contributor_type":"project_member"},{"contributor_type":"project_member","last_name":"Sonnleitner","first_name":"Elisabeth"},{"id":"350F91D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6041-254X","first_name":"Bor","last_name":"Kavcic","contributor_type":"project_member"},{"contributor_type":"project_member","last_name":"Paixão","first_name":"Tiago"},{"first_name":"Calin C","last_name":"Guet","contributor_type":"project_manager","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052"}],"author":[{"full_name":"Nagy-Staron, Anna A","last_name":"Nagy-Staron","first_name":"Anna A","orcid":"0000-0002-1391-8377","id":"3ABC5BA6-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"Published Version","file":[{"file_name":"readme.txt","access_level":"open_access","creator":"bkavcic","content_type":"text/plain","file_size":523,"file_id":"8952","relation":"main_file","date_updated":"2020-12-20T09:52:52Z","date_created":"2020-12-20T09:52:52Z","success":1,"checksum":"f57862aeee1690c7effd2b1117d40ed1"},{"creator":"bkavcic","file_size":379228,"content_type":"application/octet-stream","file_name":"GRNs Research depository.gb","access_level":"open_access","date_updated":"2020-12-20T22:01:44Z","date_created":"2020-12-20T22:01:44Z","success":1,"checksum":"f2c6d5232ec6d551b6993991e8689e9f","file_id":"8954","relation":"main_file"}],"date_created":"2020-12-20T10:00:26Z","date_updated":"2024-02-21T12:41:57Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"8951","year":"2020","department":[{"_id":"CaGu"}],"publisher":"Institute of Science and Technology Austria","ddc":["570"],"status":"public","title":"Sequences of gene regulatory network permutations for the article \"Local genetic context shapes the function of a gene regulatory network\""},{"author":[{"full_name":"Grah, Rok","orcid":"0000-0003-2539-3560","id":"483E70DE-F248-11E8-B48F-1D18A9856A87","last_name":"Grah","first_name":"Rok"}],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"7652"}]},"contributor":[{"first_name":"Calin C","last_name":"Guet","contributor_type":"project_leader","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052"}],"date_updated":"2024-02-21T12:42:31Z","date_created":"2020-01-28T10:41:49Z","file":[{"file_id":"7384","relation":"main_file","date_updated":"2020-07-14T12:47:57Z","date_created":"2020-01-28T10:39:40Z","checksum":"9d292cf5207b3829225f44c044cdb3fd","file_name":"Scripts.zip","access_level":"open_access","creator":"rgrah","file_size":73363365,"content_type":"application/zip"},{"creator":"rgrah","file_size":962,"content_type":"text/plain","file_name":"READ_ME_MAIN.txt","access_level":"open_access","date_created":"2020-01-28T10:39:30Z","date_updated":"2020-07-14T12:47:57Z","checksum":"4076ceab32ef588cc233802bab24c1ab","file_id":"7385","relation":"main_file"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7383","year":"2020","title":"Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation","status":"public","publisher":"Institute of Science and Technology Austria","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"abstract":[{"text":"Organisms cope with change by employing transcriptional regulators. However, when faced with rare environments, the evolution of transcriptional regulators and their promoters may be too slow. We ask whether the intrinsic instability of gene duplication and amplification provides a generic alternative to canonical gene regulation. By real-time monitoring of gene copy number mutations in E. coli, we show that gene duplications and amplifications enable adaptation to fluctuating environments by rapidly generating copy number, and hence expression level, polymorphism. This ‘amplification-mediated gene expression tuning’ occurs on timescales similar to canonical gene regulation and can deal with rapid environmental changes. Mathematical modeling shows that amplifications also tune gene expression in stochastic environments where transcription factor-based schemes are hard to evolve or maintain. The fleeting nature of gene amplifications gives rise to a generic population-level mechanism that relies on genetic heterogeneity to rapidly tune expression of any gene, without leaving any genomic signature.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:57Z","type":"research_data","doi":"10.15479/AT:ISTA:7383","date_published":"2020-01-28T00:00:00Z","oa":1,"citation":{"ama":"Grah R. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation. 2020. doi:10.15479/AT:ISTA:7383","ista":"Grah R. 2020. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation, Institute of Science and Technology Austria, 10.15479/AT:ISTA:7383.","ieee":"R. Grah, “Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation.” Institute of Science and Technology Austria, 2020.","apa":"Grah, R. (2020). Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7383","mla":"Grah, Rok. Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7383.","short":"R. Grah, (2020).","chicago":"Grah, Rok. “Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7383."},"day":"28","month":"01","has_accepted_license":"1","article_processing_charge":"No","keyword":["Matlab scripts","analysis of microfluidics","mathematical model"]}]