[{"oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"8193","intvolume":" 30","title":"Multiple-environment Markov decision processes: Efficient analysis and applications","status":"public","abstract":[{"lang":"eng","text":"Multiple-environment Markov decision processes (MEMDPs) are MDPs equipped with not one, but multiple probabilistic transition functions, which represent the various possible unknown environments. While the previous research on MEMDPs focused on theoretical properties for long-run average payoff, we study them with discounted-sum payoff and focus on their practical advantages and applications. MEMDPs can be viewed as a special case of Partially observable and Mixed observability MDPs: the state of the system is perfectly observable, but not the environment. We show that the specific structure of MEMDPs allows for more efficient algorithmic analysis, in particular for faster belief updates. We demonstrate the applicability of MEMDPs in several domains. In particular, we formalize the sequential decision-making approach to contextual recommendation systems as MEMDPs and substantially improve over the previous MDP approach."}],"type":"conference","date_published":"2020-06-01T00:00:00Z","citation":{"ama":"Chatterjee K, Chmelik M, Karkhanis D, Novotný P, Royer A. Multiple-environment Markov decision processes: Efficient analysis and applications. In: Proceedings of the 30th International Conference on Automated Planning and Scheduling. Vol 30. Association for the Advancement of Artificial Intelligence; 2020:48-56.","ieee":"K. Chatterjee, M. Chmelik, D. Karkhanis, P. Novotný, and A. Royer, “Multiple-environment Markov decision processes: Efficient analysis and applications,” in Proceedings of the 30th International Conference on Automated Planning and Scheduling, Nancy, France, 2020, vol. 30, pp. 48–56.","apa":"Chatterjee, K., Chmelik, M., Karkhanis, D., Novotný, P., & Royer, A. (2020). Multiple-environment Markov decision processes: Efficient analysis and applications. In Proceedings of the 30th International Conference on Automated Planning and Scheduling (Vol. 30, pp. 48–56). Nancy, France: Association for the Advancement of Artificial Intelligence.","ista":"Chatterjee K, Chmelik M, Karkhanis D, Novotný P, Royer A. 2020. Multiple-environment Markov decision processes: Efficient analysis and applications. Proceedings of the 30th International Conference on Automated Planning and Scheduling. ICAPS: International Conference on Automated Planning and Scheduling vol. 30, 48–56.","short":"K. Chatterjee, M. Chmelik, D. Karkhanis, P. Novotný, A. Royer, in:, Proceedings of the 30th International Conference on Automated Planning and Scheduling, Association for the Advancement of Artificial Intelligence, 2020, pp. 48–56.","mla":"Chatterjee, Krishnendu, et al. “Multiple-Environment Markov Decision Processes: Efficient Analysis and Applications.” Proceedings of the 30th International Conference on Automated Planning and Scheduling, vol. 30, Association for the Advancement of Artificial Intelligence, 2020, pp. 48–56.","chicago":"Chatterjee, Krishnendu, Martin Chmelik, Deep Karkhanis, Petr Novotný, and Amélie Royer. “Multiple-Environment Markov Decision Processes: Efficient Analysis and Applications.” In Proceedings of the 30th International Conference on Automated Planning and Scheduling, 30:48–56. Association for the Advancement of Artificial Intelligence, 2020."},"publication":"Proceedings of the 30th International Conference on Automated Planning and Scheduling","page":"48-56","article_processing_charge":"No","day":"01","scopus_import":"1","related_material":{"record":[{"id":"8390","status":"public","relation":"dissertation_contains"}]},"author":[{"full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Chmelik, Martin","first_name":"Martin","last_name":"Chmelik","id":"3624234E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Karkhanis, Deep","last_name":"Karkhanis","first_name":"Deep"},{"id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","first_name":"Petr","last_name":"Novotný","full_name":"Novotný, Petr"},{"id":"3811D890-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8407-0705","first_name":"Amélie","last_name":"Royer","full_name":"Royer, Amélie"}],"volume":30,"date_updated":"2023-09-07T13:16:18Z","date_created":"2020-08-02T22:00:58Z","year":"2020","acknowledgement":"Krishnendu Chatterjee is supported by the Austrian ScienceFund (FWF) NFN Grant No. S11407-N23 (RiSE/SHiNE),and COST Action GAMENET. Petr Novotn ́y is supported bythe Czech Science Foundation grant No. GJ19-15134Y.","publisher":"Association for the Advancement of Artificial Intelligence","department":[{"_id":"KrCh"}],"publication_status":"published","conference":{"name":"ICAPS: International Conference on Automated Planning and Scheduling","end_date":"2020-10-30","start_date":"2020-10-26","location":"Nancy, France"},"language":[{"iso":"eng"}],"project":[{"name":"Game Theory","call_identifier":"FWF","grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","publication_identifier":{"eissn":["23340843"],"issn":["23340835"]},"month":"06"},{"type":"book_chapter","abstract":[{"lang":"eng","text":"Image translation refers to the task of mapping images from a visual domain to another. Given two unpaired collections of images, we aim to learn a mapping between the corpus-level style of each collection, while preserving semantic content shared across the two domains. We introduce xgan, a dual adversarial auto-encoder, which captures a shared representation of the common domain semantic content in an unsupervised way, while jointly learning the domain-to-domain image translations in both directions. We exploit ideas from the domain adaptation literature and define a semantic consistency loss which encourages the learned embedding to preserve semantics shared across domains. We report promising qualitative results for the task of face-to-cartoon translation. The cartoon dataset we collected for this purpose, “CartoonSet”, is also publicly available as a new benchmark for semantic style transfer at https://google.github.io/cartoonset/index.html."}],"_id":"8092","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"XGAN: Unsupervised image-to-image translation for many-to-many mappings","oa_version":"Preprint","scopus_import":"1","article_processing_charge":"No","day":"08","citation":{"ama":"Royer A, Bousmalis K, Gouws S, et al. XGAN: Unsupervised image-to-image translation for many-to-many mappings. In: Singh R, Vatsa M, Patel VM, Ratha N, eds. Domain Adaptation for Visual Understanding. Springer Nature; 2020:33-49. doi:10.1007/978-3-030-30671-7_3","apa":"Royer, A., Bousmalis, K., Gouws, S., Bertsch, F., Mosseri, I., Cole, F., & Murphy, K. (2020). XGAN: Unsupervised image-to-image translation for many-to-many mappings. In R. Singh, M. Vatsa, V. M. Patel, & N. Ratha (Eds.), Domain Adaptation for Visual Understanding (pp. 33–49). Springer Nature. https://doi.org/10.1007/978-3-030-30671-7_3","ieee":"A. Royer et al., “XGAN: Unsupervised image-to-image translation for many-to-many mappings,” in Domain Adaptation for Visual Understanding, R. Singh, M. Vatsa, V. M. Patel, and N. Ratha, Eds. Springer Nature, 2020, pp. 33–49.","ista":"Royer A, Bousmalis K, Gouws S, Bertsch F, Mosseri I, Cole F, Murphy K. 2020.XGAN: Unsupervised image-to-image translation for many-to-many mappings. In: Domain Adaptation for Visual Understanding. , 33–49.","short":"A. Royer, K. Bousmalis, S. Gouws, F. Bertsch, I. Mosseri, F. Cole, K. Murphy, in:, R. Singh, M. Vatsa, V.M. Patel, N. Ratha (Eds.), Domain Adaptation for Visual Understanding, Springer Nature, 2020, pp. 33–49.","mla":"Royer, Amélie, et al. “XGAN: Unsupervised Image-to-Image Translation for Many-to-Many Mappings.” Domain Adaptation for Visual Understanding, edited by Richa Singh et al., Springer Nature, 2020, pp. 33–49, doi:10.1007/978-3-030-30671-7_3.","chicago":"Royer, Amélie, Konstantinos Bousmalis, Stephan Gouws, Fred Bertsch, Inbar Mosseri, Forrester Cole, and Kevin Murphy. “XGAN: Unsupervised Image-to-Image Translation for Many-to-Many Mappings.” In Domain Adaptation for Visual Understanding, edited by Richa Singh, Mayank Vatsa, Vishal M. Patel, and Nalini Ratha, 33–49. Springer Nature, 2020. https://doi.org/10.1007/978-3-030-30671-7_3."},"publication":"Domain Adaptation for Visual Understanding","page":"33-49","date_published":"2020-01-08T00:00:00Z","year":"2020","editor":[{"first_name":"Richa","last_name":"Singh","full_name":"Singh, Richa"},{"full_name":"Vatsa, Mayank","last_name":"Vatsa","first_name":"Mayank"},{"last_name":"Patel","first_name":"Vishal M.","full_name":"Patel, Vishal M."},{"first_name":"Nalini","last_name":"Ratha","full_name":"Ratha, Nalini"}],"department":[{"_id":"ChLa"}],"publisher":"Springer Nature","publication_status":"published","related_material":{"record":[{"status":"deleted","relation":"dissertation_contains","id":"8331"},{"id":"8390","relation":"dissertation_contains","status":"public"}]},"author":[{"last_name":"Royer","first_name":"Amélie","orcid":"0000-0002-8407-0705","id":"3811D890-F248-11E8-B48F-1D18A9856A87","full_name":"Royer, Amélie"},{"last_name":"Bousmalis","first_name":"Konstantinos","full_name":"Bousmalis, Konstantinos"},{"full_name":"Gouws, Stephan","last_name":"Gouws","first_name":"Stephan"},{"full_name":"Bertsch, Fred","first_name":"Fred","last_name":"Bertsch"},{"full_name":"Mosseri, Inbar","first_name":"Inbar","last_name":"Mosseri"},{"first_name":"Forrester","last_name":"Cole","full_name":"Cole, Forrester"},{"full_name":"Murphy, Kevin","last_name":"Murphy","first_name":"Kevin"}],"date_updated":"2023-09-07T13:16:18Z","date_created":"2020-07-05T22:00:46Z","publication_identifier":{"isbn":["9783030306717"]},"month":"01","main_file_link":[{"url":"https://arxiv.org/abs/1711.05139","open_access":"1"}],"external_id":{"arxiv":["1711.05139"]},"oa":1,"quality_controlled":"1","doi":"10.1007/978-3-030-30671-7_3","language":[{"iso":"eng"}]},{"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"7950"},{"id":"5986","status":"public","relation":"part_of_dissertation"}]},"author":[{"orcid":"0000-0002-6660-1322","id":"45CFE238-F248-11E8-B48F-1D18A9856A87","last_name":"Masárová","first_name":"Zuzana","full_name":"Masárová, Zuzana"}],"date_updated":"2023-09-07T13:17:37Z","date_created":"2020-06-08T00:49:46Z","year":"2020","publisher":"Institute of Science and Technology Austria","department":[{"_id":"HeEd"},{"_id":"UlWa"}],"publication_status":"published","file_date_updated":"2020-07-14T12:48:05Z","license":"https://creativecommons.org/licenses/by-sa/4.0/","doi":"10.15479/AT:ISTA:7944","language":[{"iso":"eng"}],"degree_awarded":"PhD","supervisor":[{"orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","first_name":"Uli","full_name":"Wagner, Uli"},{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","first_name":"Herbert","last_name":"Edelsbrunner"}],"tmp":{"short":"CC BY-SA (4.0)","image":"/images/cc_by_sa.png","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode"},"oa":1,"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-005-3"]},"month":"06","file":[{"file_name":"THESIS_Zuzka_Masarova.pdf","access_level":"open_access","creator":"zmasarov","content_type":"application/pdf","file_size":13661779,"file_id":"7945","relation":"main_file","date_updated":"2020-07-14T12:48:05Z","date_created":"2020-06-08T00:34:00Z","checksum":"df688bc5a82b50baee0b99d25fc7b7f0"},{"access_level":"closed","file_name":"THESIS_Zuzka_Masarova_SOURCE_FILES.zip","file_size":32184006,"content_type":"application/zip","creator":"zmasarov","relation":"source_file","file_id":"7946","checksum":"45341a35b8f5529c74010b7af43ac188","date_created":"2020-06-08T00:35:30Z","date_updated":"2020-07-14T12:48:05Z"}],"oa_version":"Published Version","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"7944","ddc":["516","514"],"title":"Reconfiguration problems","status":"public","abstract":[{"text":"This thesis considers two examples of reconfiguration problems: flipping edges in edge-labelled triangulations of planar point sets and swapping labelled tokens placed on vertices of a graph. In both cases the studied structures – all the triangulations of a given point set or all token placements on a given graph – can be thought of as vertices of the so-called reconfiguration graph, in which two vertices are adjacent if the corresponding structures differ by a single elementary operation – by a flip of a diagonal in a triangulation or by a swap of tokens on adjacent vertices, respectively. We study the reconfiguration of one instance of a structure into another via (shortest) paths in the reconfiguration graph.\r\n\r\nFor triangulations of point sets in which each edge has a unique label and a flip transfers the label from the removed edge to the new edge, we prove a polynomial-time testable condition, called the Orbit Theorem, that characterizes when two triangulations of the same point set lie in the same connected component of the reconfiguration graph. The condition was first conjectured by Bose, Lubiw, Pathak and Verdonschot. We additionally provide a polynomial time algorithm that computes a reconfiguring flip sequence, if it exists. Our proof of the Orbit Theorem uses topological properties of a certain high-dimensional cell complex that has the usual reconfiguration graph as its 1-skeleton.\r\n\r\nIn the context of token swapping on a tree graph, we make partial progress on the problem of finding shortest reconfiguration sequences. We disprove the so-called Happy Leaf Conjecture and demonstrate the importance of swapping tokens that are already placed at the correct vertices. We also prove that a generalization of the problem to weighted coloured token swapping is NP-hard on trees but solvable in polynomial time on paths and stars.","lang":"eng"}],"type":"dissertation","alternative_title":["ISTA Thesis"],"date_published":"2020-06-09T00:00:00Z","citation":{"ieee":"Z. Masárová, “Reconfiguration problems,” Institute of Science and Technology Austria, 2020.","apa":"Masárová, Z. (2020). Reconfiguration problems. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7944","ista":"Masárová Z. 2020. Reconfiguration problems. Institute of Science and Technology Austria.","ama":"Masárová Z. Reconfiguration problems. 2020. doi:10.15479/AT:ISTA:7944","chicago":"Masárová, Zuzana. “Reconfiguration Problems.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7944.","short":"Z. Masárová, Reconfiguration Problems, Institute of Science and Technology Austria, 2020.","mla":"Masárová, Zuzana. Reconfiguration Problems. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7944."},"page":"160","has_accepted_license":"1","article_processing_charge":"No","day":"09","keyword":["reconfiguration","reconfiguration graph","triangulations","flip","constrained triangulations","shellability","piecewise-linear balls","token swapping","trees","coloured weighted token swapping"]},{"type":"journal_article","issue":"16","abstract":[{"lang":"eng","text":"Inspired by the possibility to experimentally manipulate and enhance chemical reactivity in helium nanodroplets, we investigate the effective interaction and the resulting correlations between two diatomic molecules immersed in a bath of bosons. By analogy with the bipolaron, we introduce the biangulon quasiparticle describing two rotating molecules that align with respect to each other due to the effective attractive interaction mediated by the excitations of the bath. We study this system in different parameter regimes and apply several theoretical approaches to describe its properties. Using a Born–Oppenheimer approximation, we investigate the dependence of the effective intermolecular interaction on the rotational state of the two molecules. In the strong-coupling regime, a product-state ansatz shows that the molecules tend to have a strong alignment in the ground state. To investigate the system in the weak-coupling regime, we apply a one-phonon excitation variational ansatz, which allows us to access the energy spectrum. In comparison to the angulon quasiparticle, the biangulon shows shifted angulon instabilities and an additional spectral instability, where resonant angular momentum transfer between the molecules and the bath takes place. These features are proposed as an experimentally observable signature for the formation of the biangulon quasiparticle. Finally, by using products of single angulon and bare impurity wave functions as basis states, we introduce a diagonalization scheme that allows us to describe the transition from two separated angulons to a biangulon as a function of the distance between the two molecules."}],"intvolume":" 152","title":"Intermolecular forces and correlations mediated by a phonon bath","status":"public","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"8587","oa_version":"Preprint","keyword":["Physical and Theoretical Chemistry","General Physics and Astronomy"],"article_processing_charge":"No","day":"27","article_type":"original","citation":{"short":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, A. Deuchert, The Journal of Chemical Physics 152 (2020).","mla":"Li, Xiang, et al. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” The Journal of Chemical Physics, vol. 152, no. 16, 164302, AIP Publishing, 2020, doi:10.1063/1.5144759.","chicago":"Li, Xiang, Enderalp Yakaboylu, Giacomo Bighin, Richard Schmidt, Mikhail Lemeshko, and Andreas Deuchert. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” The Journal of Chemical Physics. AIP Publishing, 2020. https://doi.org/10.1063/1.5144759.","ama":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. Intermolecular forces and correlations mediated by a phonon bath. The Journal of Chemical Physics. 2020;152(16). doi:10.1063/1.5144759","ieee":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, and A. Deuchert, “Intermolecular forces and correlations mediated by a phonon bath,” The Journal of Chemical Physics, vol. 152, no. 16. AIP Publishing, 2020.","apa":"Li, X., Yakaboylu, E., Bighin, G., Schmidt, R., Lemeshko, M., & Deuchert, A. (2020). Intermolecular forces and correlations mediated by a phonon bath. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/1.5144759","ista":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. 2020. Intermolecular forces and correlations mediated by a phonon bath. The Journal of Chemical Physics. 152(16), 164302."},"publication":"The Journal of Chemical Physics","date_published":"2020-04-27T00:00:00Z","article_number":"164302","ec_funded":1,"department":[{"_id":"MiLe"},{"_id":"RoSe"}],"publisher":"AIP Publishing","publication_status":"published","year":"2020","acknowledgement":"We are grateful to Areg Ghazaryan for valuable discussions. M.L. acknowledges support from the Austrian Science Fund (FWF) under Project No. P29902-N27 and from the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). G.B. acknowledges support from the Austrian Science Fund (FWF) under Project No. M2461-N27. A.D. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the European Research Council (ERC) Grant Agreement No. 694227 and under the Marie Sklodowska-Curie Grant Agreement No. 836146. R.S. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2111 – 390814868.","volume":152,"date_updated":"2023-09-07T13:16:42Z","date_created":"2020-09-30T10:33:17Z","related_material":{"record":[{"id":"8958","relation":"dissertation_contains","status":"public"}]},"author":[{"id":"4B7E523C-F248-11E8-B48F-1D18A9856A87","last_name":"Li","first_name":"Xiang","full_name":"Li, Xiang"},{"last_name":"Yakaboylu","first_name":"Enderalp","orcid":"0000-0001-5973-0874","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","full_name":"Yakaboylu, Enderalp"},{"full_name":"Bighin, Giacomo","first_name":"Giacomo","last_name":"Bighin","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8823-9777"},{"last_name":"Schmidt","first_name":"Richard","full_name":"Schmidt, Richard"},{"full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","first_name":"Mikhail","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Deuchert","first_name":"Andreas","orcid":"0000-0003-3146-6746","id":"4DA65CD0-F248-11E8-B48F-1D18A9856A87","full_name":"Deuchert, Andreas"}],"publication_identifier":{"issn":["0021-9606"],"eissn":["1089-7690"]},"month":"04","project":[{"name":"Quantum rotations in the presence of a many-body environment","call_identifier":"FWF","grant_number":"P29902","_id":"26031614-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770"},{"grant_number":"M02641","_id":"26986C82-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"A path-integral approach to composite impurities"},{"grant_number":"694227","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","call_identifier":"H2020"}],"isi":1,"quality_controlled":"1","external_id":{"arxiv":["1912.02658"],"isi":["000530448300001"]},"main_file_link":[{"url":"https://arxiv.org/abs/1912.02658","open_access":"1"}],"oa":1,"language":[{"iso":"eng"}],"doi":"10.1063/1.5144759"},{"_id":"8341","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ddc":["570"],"status":"public","title":"In vitro reconstitution of a Rab activation switch","oa_version":"Published Version","file":[{"file_size":65246782,"content_type":"application/x-zip-compressed","creator":"dernst","access_level":"closed","file_name":"2020_Urban_Bezeljak_Thesis_TeX.zip","checksum":"70871b335a595252a66c6bbf0824fb02","date_updated":"2021-09-16T12:49:12Z","date_created":"2020-09-08T09:00:29Z","relation":"source_file","file_id":"8342"},{"checksum":"59a62275088b00b7241e6ff4136434c7","date_created":"2020-09-08T09:00:27Z","date_updated":"2021-09-16T12:49:12Z","file_id":"8343","relation":"main_file","creator":"dernst","file_size":31259058,"content_type":"application/pdf","access_level":"open_access","file_name":"2020_Urban_Bezeljak_Thesis.pdf"}],"type":"dissertation","alternative_title":["ISTA Thesis"],"abstract":[{"text":"One of the most striking hallmarks of the eukaryotic cell is the presence of intracellular vesicles and organelles. Each of these membrane-enclosed compartments has a distinct composition of lipids and proteins, which is essential for accurate membrane traffic and homeostasis. Interestingly, their biochemical identities are achieved with the help\r\nof small GTPases of the Rab family, which cycle between GDP- and GTP-bound forms on the selected membrane surface. While this activity switch is well understood for an individual protein, how Rab GTPases collectively transition between states to generate decisive signal propagation in space and time is unclear. In my PhD thesis, I present\r\nin vitro reconstitution experiments with theoretical modeling to systematically study a minimal Rab5 activation network from bottom-up. We find that positive feedback based on known molecular interactions gives rise to bistable GTPase activity switching on system’s scale. Furthermore, we determine that collective transition near the critical\r\npoint is intrinsically stochastic and provide evidence that the inactive Rab5 abundance on the membrane can shape the network response. Finally, we demonstrate that collective switching can spread on the lipid bilayer as a traveling activation wave, representing a possible emergent activity pattern in endosomal maturation. Together, our\r\nfindings reveal new insights into the self-organization properties of signaling networks away from chemical equilibrium. Our work highlights the importance of systematic characterization of biochemical systems in well-defined physiological conditions. This way, we were able to answer long-standing open questions in the field and close the gap between regulatory processes on a molecular scale and emergent responses on system’s level.","lang":"eng"}],"citation":{"chicago":"Bezeljak, Urban. “In Vitro Reconstitution of a Rab Activation Switch.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8341.","mla":"Bezeljak, Urban. In Vitro Reconstitution of a Rab Activation Switch. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8341.","short":"U. Bezeljak, In Vitro Reconstitution of a Rab Activation Switch, Institute of Science and Technology Austria, 2020.","ista":"Bezeljak U. 2020. In vitro reconstitution of a Rab activation switch. Institute of Science and Technology Austria.","ieee":"U. Bezeljak, “In vitro reconstitution of a Rab activation switch,” Institute of Science and Technology Austria, 2020.","apa":"Bezeljak, U. (2020). In vitro reconstitution of a Rab activation switch. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8341","ama":"Bezeljak U. In vitro reconstitution of a Rab activation switch. 2020. doi:10.15479/AT:ISTA:8341"},"page":"215","date_published":"2020-09-08T00:00:00Z","day":"08","article_processing_charge":"No","has_accepted_license":"1","year":"2020","acknowledgement":"My thanks goes to the Loose lab members, BioImaging, Life Science and Nanofabrication Facilities and the wonderful international community at IST for sharing this experience with me.","publication_status":"published","department":[{"_id":"MaLo"}],"publisher":"Institute of Science and Technology Austria","author":[{"full_name":"Bezeljak, Urban","last_name":"Bezeljak","first_name":"Urban","orcid":"0000-0003-1365-5631","id":"2A58201A-F248-11E8-B48F-1D18A9856A87"}],"related_material":{"record":[{"id":"7580","status":"public","relation":"part_of_dissertation"}]},"date_updated":"2023-09-07T13:17:06Z","date_created":"2020-09-08T08:53:53Z","file_date_updated":"2021-09-16T12:49:12Z","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"oa":1,"doi":"10.15479/AT:ISTA:8341","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"NanoFab"}],"supervisor":[{"full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","first_name":"Martin","last_name":"Loose"}],"degree_awarded":"PhD","language":[{"iso":"eng"}],"month":"09","publication_identifier":{"issn":["2663-337X"]}}]