[{"type":"journal_article","article_type":"original","status":"public","_id":"6843","department":[{"_id":"LaEr"}],"date_updated":"2023-08-29T07:18:50Z","main_file_link":[{"url":"https://arxiv.org/abs/1809.01101","open_access":"1"}],"scopus_import":"1","intvolume":" 480","month":"12","abstract":[{"lang":"eng","text":"The aim of this short paper is to offer a complete characterization of all (not necessarily surjective) isometric embeddings of the Wasserstein space Wp(X), where S is a countable discrete metric space and 0
Journal of Mathematical Analysis and Applications. Elsevier, 2019. https://doi.org/10.1016/j.jmaa.2019.123435.","short":"G.P. Gehér, T. Titkos, D. Virosztek, Journal of Mathematical Analysis and Applications 480 (2019).","ieee":"G. P. Gehér, T. Titkos, and D. Virosztek, “On isometric embeddings of Wasserstein spaces – the discrete case,” Journal of Mathematical Analysis and Applications, vol. 480, no. 2. Elsevier, 2019.","apa":"Gehér, G. P., Titkos, T., & Virosztek, D. (2019). On isometric embeddings of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis and Applications. Elsevier. https://doi.org/10.1016/j.jmaa.2019.123435","ama":"Gehér GP, Titkos T, Virosztek D. On isometric embeddings of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis and Applications. 2019;480(2). doi:10.1016/j.jmaa.2019.123435","mla":"Gehér, György Pál, et al. “On Isometric Embeddings of Wasserstein Spaces – the Discrete Case.” Journal of Mathematical Analysis and Applications, vol. 480, no. 2, 123435, Elsevier, 2019, doi:10.1016/j.jmaa.2019.123435."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"publisher":"Elsevier","quality_controlled":"1","date_created":"2019-09-01T22:01:01Z","date_published":"2019-12-15T00:00:00Z","doi":"10.1016/j.jmaa.2019.123435","year":"2019","isi":1,"publication":"Journal of Mathematical Analysis and Applications","day":"15"},{"article_number":"102794","title":"Rational points and prime values of polynomials in moderately many variables","article_processing_charge":"No","external_id":{"isi":["000496342100002"],"arxiv":["1801.03082"]},"author":[{"full_name":"Destagnol, Kevin N","last_name":"Destagnol","id":"44DDECBC-F248-11E8-B48F-1D18A9856A87","first_name":"Kevin N"},{"first_name":"Efthymios","full_name":"Sofos, Efthymios","last_name":"Sofos"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Destagnol, Kevin N, and Efthymios Sofos. “Rational Points and Prime Values of Polynomials in Moderately Many Variables.” Bulletin Des Sciences Mathematiques. Elsevier, 2019. https://doi.org/10.1016/j.bulsci.2019.102794.","ista":"Destagnol KN, Sofos E. 2019. Rational points and prime values of polynomials in moderately many variables. Bulletin des Sciences Mathematiques. 156(11), 102794.","mla":"Destagnol, Kevin N., and Efthymios Sofos. “Rational Points and Prime Values of Polynomials in Moderately Many Variables.” Bulletin Des Sciences Mathematiques, vol. 156, no. 11, 102794, Elsevier, 2019, doi:10.1016/j.bulsci.2019.102794.","short":"K.N. Destagnol, E. Sofos, Bulletin Des Sciences Mathematiques 156 (2019).","ieee":"K. N. Destagnol and E. Sofos, “Rational points and prime values of polynomials in moderately many variables,” Bulletin des Sciences Mathematiques, vol. 156, no. 11. Elsevier, 2019.","ama":"Destagnol KN, Sofos E. Rational points and prime values of polynomials in moderately many variables. Bulletin des Sciences Mathematiques. 2019;156(11). doi:10.1016/j.bulsci.2019.102794","apa":"Destagnol, K. N., & Sofos, E. (2019). Rational points and prime values of polynomials in moderately many variables. Bulletin Des Sciences Mathematiques. Elsevier. https://doi.org/10.1016/j.bulsci.2019.102794"},"oa":1,"publisher":"Elsevier","quality_controlled":"1","date_created":"2019-09-01T22:00:55Z","doi":"10.1016/j.bulsci.2019.102794","date_published":"2019-11-01T00:00:00Z","publication":"Bulletin des Sciences Mathematiques","day":"01","year":"2019","isi":1,"status":"public","type":"journal_article","article_type":"original","_id":"6835","department":[{"_id":"TiBr"}],"date_updated":"2023-08-29T07:18:02Z","intvolume":" 156","month":"11","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1801.03082"}],"scopus_import":"1","oa_version":"Preprint","abstract":[{"text":"We derive the Hasse principle and weak approximation for fibrations of certain varieties in the spirit of work by Colliot-Thélène–Sansuc and Harpaz–Skorobogatov–Wittenberg. Our varieties are defined through polynomials in many variables and part of our work is devoted to establishing Schinzel's hypothesis for polynomials of this kind. This last part is achieved by using arguments behind Birch's well-known result regarding the Hasse principle for complete intersections with the notable difference that we prove our result in 50% fewer variables than in the classical Birch setting. We also study the problem of square-free values of an integer polynomial with 66.6% fewer variables than in the Birch setting.","lang":"eng"}],"issue":"11","volume":156,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0007-4497"]}},{"publication":"Nature Cell Biology","day":"01","year":"2019","isi":1,"date_created":"2019-09-01T22:00:57Z","doi":"10.1038/s41556-019-0369-3","date_published":"2019-08-01T00:00:00Z","page":"918-920","publisher":"Springer Nature","quality_controlled":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Tavano, Ste, and Carl-Philipp J Heisenberg. “Migrasomes Take Center Stage.” Nature Cell Biology. Springer Nature, 2019. https://doi.org/10.1038/s41556-019-0369-3.","ista":"Tavano S, Heisenberg C-PJ. 2019. Migrasomes take center stage. Nature Cell Biology. 21(8), 918–920.","mla":"Tavano, Ste, and Carl-Philipp J. Heisenberg. “Migrasomes Take Center Stage.” Nature Cell Biology, vol. 21, no. 8, Springer Nature, 2019, pp. 918–20, doi:10.1038/s41556-019-0369-3.","ama":"Tavano S, Heisenberg C-PJ. Migrasomes take center stage. Nature Cell Biology. 2019;21(8):918-920. doi:10.1038/s41556-019-0369-3","apa":"Tavano, S., & Heisenberg, C.-P. J. (2019). Migrasomes take center stage. Nature Cell Biology. Springer Nature. https://doi.org/10.1038/s41556-019-0369-3","ieee":"S. Tavano and C.-P. J. Heisenberg, “Migrasomes take center stage,” Nature Cell Biology, vol. 21, no. 8. Springer Nature, pp. 918–920, 2019.","short":"S. Tavano, C.-P.J. Heisenberg, Nature Cell Biology 21 (2019) 918–920."},"title":"Migrasomes take center stage","external_id":{"pmid":["31371826"],"isi":["000478029000003"]},"article_processing_charge":"No","author":[{"last_name":"Tavano","full_name":"Tavano, Ste","orcid":"0000-0001-9970-7804","id":"2F162F0C-F248-11E8-B48F-1D18A9856A87","first_name":"Ste"},{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"}],"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"eissn":["1476-4679"]},"issue":"8","volume":21,"pmid":1,"oa_version":"None","abstract":[{"text":"Migrasomes are a recently discovered type of extracellular vesicles that are characteristically generated along retraction fibers in migrating cells. Two studies now show how migrasomes are formed and how they function in the physiologically relevant context of the developing zebrafish embryo.","lang":"eng"}],"intvolume":" 21","month":"08","scopus_import":"1","date_updated":"2023-08-29T07:42:20Z","department":[{"_id":"CaHe"}],"_id":"6837","status":"public","type":"journal_article"},{"article_number":"12625","title":"A novel magnet-based scratch method for standardisation of wound-healing assays","external_id":{"pmid":["31477739"],"isi":["000483697800007"]},"article_processing_charge":"No","author":[{"last_name":"Fenu","full_name":"Fenu, M.","first_name":"M."},{"first_name":"T.","last_name":"Bettermann","full_name":"Bettermann, T."},{"first_name":"C.","full_name":"Vogl, C.","last_name":"Vogl"},{"last_name":"Darwish-Miranda","full_name":"Darwish-Miranda, Nasser","orcid":"0000-0002-8821-8236","first_name":"Nasser","id":"39CD9926-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schramel, J.","last_name":"Schramel","first_name":"J."},{"full_name":"Jenner, F.","last_name":"Jenner","first_name":"F."},{"last_name":"Ribitsch","full_name":"Ribitsch, I.","first_name":"I."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ieee":"M. Fenu et al., “A novel magnet-based scratch method for standardisation of wound-healing assays,” Scientific Reports, vol. 9, no. 1. Springer Nature, 2019.","short":"M. Fenu, T. Bettermann, C. Vogl, N. Darwish-Miranda, J. Schramel, F. Jenner, I. Ribitsch, Scientific Reports 9 (2019).","ama":"Fenu M, Bettermann T, Vogl C, et al. A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. 2019;9(1). doi:10.1038/s41598-019-48930-7","apa":"Fenu, M., Bettermann, T., Vogl, C., Darwish-Miranda, N., Schramel, J., Jenner, F., & Ribitsch, I. (2019). A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-019-48930-7","mla":"Fenu, M., et al. “A Novel Magnet-Based Scratch Method for Standardisation of Wound-Healing Assays.” Scientific Reports, vol. 9, no. 1, 12625, Springer Nature, 2019, doi:10.1038/s41598-019-48930-7.","ista":"Fenu M, Bettermann T, Vogl C, Darwish-Miranda N, Schramel J, Jenner F, Ribitsch I. 2019. A novel magnet-based scratch method for standardisation of wound-healing assays. Scientific Reports. 9(1), 12625.","chicago":"Fenu, M., T. Bettermann, C. Vogl, Nasser Darwish-Miranda, J. Schramel, F. Jenner, and I. Ribitsch. “A Novel Magnet-Based Scratch Method for Standardisation of Wound-Healing Assays.” Scientific Reports. Springer Nature, 2019. https://doi.org/10.1038/s41598-019-48930-7."},"oa":1,"quality_controlled":"1","publisher":"Springer Nature","date_created":"2019-09-15T22:00:42Z","doi":"10.1038/s41598-019-48930-7","date_published":"2019-09-02T00:00:00Z","publication":"Scientific Reports","day":"02","year":"2019","has_accepted_license":"1","isi":1,"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","_id":"6867","file_date_updated":"2020-07-14T12:47:42Z","department":[{"_id":"Bio"}],"ddc":["570"],"date_updated":"2023-08-29T07:55:15Z","intvolume":" 9","month":"09","scopus_import":"1","oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng","text":"A novel magnetic scratch method achieves repeatability, reproducibility and geometric control greater than pipette scratch assays and closely approximating the precision of cell exclusion assays while inducing the cell injury inherently necessary for wound healing assays. The magnetic scratch is affordable, easily implemented and standardisable and thus may contribute toward better comparability of data generated in different studies and laboratories."}],"issue":"1","volume":9,"language":[{"iso":"eng"}],"file":[{"checksum":"9cfd986d4108e288cc72276ef047ab0c","file_id":"6879","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"2019_ScientificReports_Fenu.pdf","date_created":"2019-09-16T12:42:40Z","file_size":3523795,"date_updated":"2020-07-14T12:47:42Z","creator":"dernst"}],"publication_status":"published","publication_identifier":{"eissn":["20452322"]}},{"date_updated":"2023-08-29T07:52:02Z","department":[{"_id":"LeSa"}],"_id":"6859","status":"public","type":"journal_article","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"publication_status":"published","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/structure-of-protein-nano-turbine-revealed/","description":"News on IST Website"}]},"volume":365,"issue":"6455","pmid":1,"oa_version":"None","acknowledged_ssus":[{"_id":"ScienComp"}],"abstract":[{"text":"V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found in archaeaand eubacteria, couple ATP hydrolysis or synthesis to proton translocation across theplasma membrane using the rotary-catalysis mechanism. They belong to the V-typeATPase family, which differs from the mitochondrial/chloroplast F-type ATP synthasesin overall architecture. We solved cryo–electron microscopy structures of the intactThermus thermophilusV/A-ATPase, reconstituted into lipid nanodiscs, in three rotationalstates and two substates. These structures indicate substantial flexibility betweenV1and Voin a working enzyme, which results from mechanical competition between centralshaft rotation and resistance from the peripheral stalks. We also describedetails of adenosine diphosphate inhibition release, V1-Votorque transmission, andproton translocation, which are relevant for the entire V-type ATPase family.","lang":"eng"}],"month":"08","intvolume":" 365","scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Zhou, Long, and Leonid A. Sazanov. “Structure and Conformational Plasticity of the Intact Thermus Thermophilus V/A-Type ATPase.” Science, vol. 365, no. 6455, eaaw9144, AAAS, 2019, doi:10.1126/science.aaw9144.","ama":"Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 2019;365(6455). doi:10.1126/science.aaw9144","apa":"Zhou, L., & Sazanov, L. A. (2019). Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. AAAS. https://doi.org/10.1126/science.aaw9144","ieee":"L. Zhou and L. A. Sazanov, “Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase,” Science, vol. 365, no. 6455. AAAS, 2019.","short":"L. Zhou, L.A. Sazanov, Science 365 (2019).","chicago":"Zhou, Long, and Leonid A Sazanov. “Structure and Conformational Plasticity of the Intact Thermus Thermophilus V/A-Type ATPase.” Science. AAAS, 2019. https://doi.org/10.1126/science.aaw9144.","ista":"Zhou L, Sazanov LA. 2019. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 365(6455), eaaw9144."},"title":"Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase","author":[{"id":"3E751364-F248-11E8-B48F-1D18A9856A87","first_name":"Long","last_name":"Zhou","orcid":"0000-0002-1864-8951","full_name":"Zhou, Long"},{"orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"pmid":["31439765"],"isi":["000482464000043"]},"article_processing_charge":"No","article_number":"eaaw9144","day":"23","publication":"Science","isi":1,"year":"2019","date_published":"2019-08-23T00:00:00Z","doi":"10.1126/science.aaw9144","date_created":"2019-09-07T19:04:45Z","quality_controlled":"1","publisher":"AAAS"},{"quality_controlled":"1","publisher":"Oxford University Press","oa":1,"day":"01","publication":"National Science Review","has_accepted_license":"1","isi":1,"year":"2019","doi":"10.1093/nsr/nwy113","date_published":"2019-03-01T00:00:00Z","date_created":"2019-09-07T14:43:02Z","page":"291-292","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” National Science Review. Oxford University Press, 2019. https://doi.org/10.1093/nsr/nwy113.","ista":"Barton NH. 2019. Is speciation driven by cycles of mixing and isolation? National Science Review. 6(2), 291–292.","mla":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” National Science Review, vol. 6, no. 2, Oxford University Press, 2019, pp. 291–92, doi:10.1093/nsr/nwy113.","ieee":"N. H. Barton, “Is speciation driven by cycles of mixing and isolation?,” National Science Review, vol. 6, no. 2. Oxford University Press, pp. 291–292, 2019.","short":"N.H. Barton, National Science Review 6 (2019) 291–292.","apa":"Barton, N. H. (2019). Is speciation driven by cycles of mixing and isolation? National Science Review. Oxford University Press. https://doi.org/10.1093/nsr/nwy113","ama":"Barton NH. Is speciation driven by cycles of mixing and isolation? National Science Review. 2019;6(2):291-292. doi:10.1093/nsr/nwy113"},"title":"Is speciation driven by cycles of mixing and isolation?","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton"}],"external_id":{"isi":["000467957400025"]},"article_processing_charge":"No","oa_version":"Published Version","month":"03","intvolume":" 6","scopus_import":"1","file":[{"relation":"main_file","access_level":"open_access","content_type":"application/pdf","success":1,"checksum":"571d60fa21a568607d1fd04e119da88c","file_id":"8595","creator":"dernst","file_size":106463,"date_updated":"2020-10-02T09:16:44Z","file_name":"2019_NSR_Barton.pdf","date_created":"2020-10-02T09:16:44Z"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2095-5138"],"eissn":["2053-714X"]},"publication_status":"published","issue":"2","volume":6,"_id":"6858","status":"public","type":"journal_article","article_type":"review","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["570"],"date_updated":"2023-08-29T07:51:09Z","department":[{"_id":"NiBa"}],"file_date_updated":"2020-10-02T09:16:44Z"},{"scopus_import":"1","month":"09","intvolume":" 8","abstract":[{"lang":"eng","text":"Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical rhythmicity and excitability in the heart and brain, but the function of HCN channels at the subcellular level in axons remains poorly understood. Here, we show that the action potential conduction velocity in both myelinated and unmyelinated central axons can be bidirectionally modulated by a HCN channel blocker, cyclic adenosine monophosphate (cAMP), and neuromodulators. Recordings from mouse cerebellar mossy fiber boutons show that HCN channels ensure reliable high-frequency firing and are strongly modulated by cAMP (EC50 40 mM; estimated endogenous cAMP concentration 13 mM). In addition, immunogold-electron microscopy revealed HCN2 as the dominating subunit in cerebellar mossy fibers. Computational modeling indicated that HCN2 channels control conduction velocity primarily by altering the resting membrane potential\r\nand are associated with significant metabolic costs. These results suggest that the cAMP-HCN pathway provides neuromodulators with an opportunity to finely tune energy consumption and temporal delays across axons in the brain."}],"oa_version":"Published Version","volume":8,"publication_identifier":{"eissn":["2050084X"]},"publication_status":"published","file":[{"file_name":"2019_eLife_Byczkowicz.pdf","date_created":"2019-09-16T13:14:33Z","creator":"dernst","file_size":4008137,"date_updated":"2020-07-14T12:47:42Z","checksum":"c350b7861ef0fb537cae8a3232aec016","file_id":"6880","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","_id":"6868","file_date_updated":"2020-07-14T12:47:42Z","department":[{"_id":"RySh"}],"date_updated":"2023-08-30T06:17:06Z","ddc":["570"],"quality_controlled":"1","publisher":"eLife Sciences Publications","oa":1,"doi":"10.7554/eLife.42766","date_published":"2019-09-09T00:00:00Z","date_created":"2019-09-15T22:00:43Z","has_accepted_license":"1","isi":1,"year":"2019","day":"09","publication":"eLife","article_number":"e42766","author":[{"first_name":"Niklas","last_name":"Byczkowicz","full_name":"Byczkowicz, Niklas"},{"first_name":"Abdelmoneim","full_name":"Eshra, Abdelmoneim","last_name":"Eshra"},{"id":"3786AB44-F248-11E8-B48F-1D18A9856A87","first_name":"Jacqueline-Claire","last_name":"Montanaro-Punzengruber","full_name":"Montanaro-Punzengruber, Jacqueline-Claire"},{"first_name":"Andrea","full_name":"Trevisiol, Andrea","last_name":"Trevisiol"},{"last_name":"Hirrlinger","full_name":"Hirrlinger, Johannes","first_name":"Johannes"},{"last_name":"Kole","full_name":"Kole, Maarten Hp","first_name":"Maarten Hp"},{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hallermann, Stefan","last_name":"Hallermann","first_name":"Stefan"}],"external_id":{"isi":["000485663900001"]},"article_processing_charge":"No","title":"HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons","citation":{"chicago":"Byczkowicz, Niklas, Abdelmoneim Eshra, Jacqueline-Claire Montanaro-Punzengruber, Andrea Trevisiol, Johannes Hirrlinger, Maarten Hp Kole, Ryuichi Shigemoto, and Stefan Hallermann. “HCN Channel-Mediated Neuromodulation Can Control Action Potential Velocity and Fidelity in Central Axons.” ELife. eLife Sciences Publications, 2019. https://doi.org/10.7554/eLife.42766.","ista":"Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, Trevisiol A, Hirrlinger J, Kole MH, Shigemoto R, Hallermann S. 2019. HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. eLife. 8, e42766.","mla":"Byczkowicz, Niklas, et al. “HCN Channel-Mediated Neuromodulation Can Control Action Potential Velocity and Fidelity in Central Axons.” ELife, vol. 8, e42766, eLife Sciences Publications, 2019, doi:10.7554/eLife.42766.","apa":"Byczkowicz, N., Eshra, A., Montanaro-Punzengruber, J.-C., Trevisiol, A., Hirrlinger, J., Kole, M. H., … Hallermann, S. (2019). HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.42766","ama":"Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, et al. HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons. eLife. 2019;8. doi:10.7554/eLife.42766","ieee":"N. Byczkowicz et al., “HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons,” eLife, vol. 8. eLife Sciences Publications, 2019.","short":"N. Byczkowicz, A. Eshra, J.-C. Montanaro-Punzengruber, A. Trevisiol, J. Hirrlinger, M.H. Kole, R. Shigemoto, S. Hallermann, ELife 8 (2019)."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Zhu, Qiang, Marçal Gallemi, Jiří Pospíšil, Petra Žádníková, Miroslav Strnad, and Eva Benková. “Root Gravity Response Module Guides Differential Growth Determining Both Root Bending and Apical Hook Formation in Arabidopsis.” Development. The Company of Biologists, 2019. https://doi.org/10.1242/dev.175919.","ista":"Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. 2019. Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. 146(17), dev175919.","mla":"Zhu, Qiang, et al. “Root Gravity Response Module Guides Differential Growth Determining Both Root Bending and Apical Hook Formation in Arabidopsis.” Development, vol. 146, no. 17, dev175919, The Company of Biologists, 2019, doi:10.1242/dev.175919.","short":"Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, E. Benková, Development 146 (2019).","ieee":"Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, and E. Benková, “Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis,” Development, vol. 146, no. 17. The Company of Biologists, 2019.","ama":"Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. 2019;146(17). doi:10.1242/dev.175919","apa":"Zhu, Q., Gallemi, M., Pospíšil, J., Žádníková, P., Strnad, M., & Benková, E. (2019). Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis. Development. The Company of Biologists. https://doi.org/10.1242/dev.175919"},"title":"Root gravity response module guides differential growth determining both root bending and apical hook formation in Arabidopsis","article_processing_charge":"No","external_id":{"isi":["000486297400011"],"pmid":["31391194"]},"author":[{"first_name":"Qiang","id":"40A4B9E6-F248-11E8-B48F-1D18A9856A87","last_name":"Zhu","full_name":"Zhu, Qiang"},{"last_name":"Gallemi","full_name":"Gallemi, Marçal","orcid":"0000-0003-4675-6893","id":"460C6802-F248-11E8-B48F-1D18A9856A87","first_name":"Marçal"},{"last_name":"Pospíšil","full_name":"Pospíšil, Jiří","first_name":"Jiří"},{"first_name":"Petra","full_name":"Žádníková, Petra","last_name":"Žádníková"},{"last_name":"Strnad","full_name":"Strnad, Miroslav","first_name":"Miroslav"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","last_name":"Benková"}],"article_number":"dev175919","project":[{"_id":"253FCA6A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"207362","name":"Hormonal cross-talk in plant organogenesis"}],"publication":"Development","day":"12","year":"2019","isi":1,"date_created":"2019-09-22T22:00:36Z","date_published":"2019-09-12T00:00:00Z","doi":"10.1242/dev.175919","acknowledgement":"We thank Jiri Friml and Phillip Brewer for inspiring discussion and for help in preparing the manuscript. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Bioimaging Facility\r\n(BIF), the Life Science Facility (LSF).\r\nThis work was supported by grants from the European Research Council (Starting Independent Research Grant ERC-2007-Stg- 207362-HCPO to E.B.). J.P. and M.S. received funds from European Regional Development Fund-Project ‘Centre for Experimental Plant Biology’ (No. CZ.02.1.01/0.0/0.0/16_019/0000738).","oa":1,"quality_controlled":"1","publisher":"The Company of Biologists","date_updated":"2023-08-30T06:19:04Z","department":[{"_id":"EvBe"}],"_id":"6897","status":"public","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"eissn":["14779129"]},"ec_funded":1,"issue":"17","volume":146,"pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"The apical hook is a transiently formed structure that plays a protective role when the germinating seedling penetrates through the soil towards the surface. Crucial for proper bending is the local auxin maxima, which defines the concave (inner) side of the hook curvature. As no sign of asymmetric auxin distribution has been reported in embryonic hypocotyls prior to hook formation, the question of how auxin asymmetry is established in the early phases of seedling germination remains largely unanswered. Here, we analyzed the auxin distribution and expression of PIN auxin efflux carriers from early phases of germination, and show that bending of the root in response to gravity is the crucial initial cue that governs the hypocotyl bending required for apical hook formation. Importantly, polar auxin transport machinery is established gradually after germination starts as a result of tight root-hypocotyl interaction and a proper balance between abscisic acid and gibberellins."}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"intvolume":" 146","month":"09","main_file_link":[{"url":"https://doi.org/10.1242/dev.175919","open_access":"1"}],"scopus_import":"1"},{"department":[{"_id":"GaNo"}],"date_updated":"2023-08-30T06:19:49Z","status":"public","article_type":"original","type":"journal_article","_id":"6896","volume":1724,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"eissn":["18726240"],"issn":["00068993"]},"intvolume":" 1724","month":"12","scopus_import":"1","oa_version":"None","pmid":1,"abstract":[{"lang":"eng","text":"Until recently, a great amount of brain studies have been conducted in human post mortem tissues, cell lines and model organisms. These researches provided useful insights regarding cell-cell interactions occurring in the brain. However, such approaches suffer from technical limitations and inaccurate modeling of the tissue 3D cytoarchitecture. Importantly, they might lack a human genetic background essential for disease modeling. With the development of protocols to generate human cerebral organoids, we are now closer to reproducing the early stages of human brain development in vitro. As a result, more relevant cell-cell interaction studies can be conducted.\r\n\r\nIn this review, we discuss the advantages of 3D cultures over 2D in modulating brain cell-cell interactions during physiological and pathological development, as well as the progress made in developing organoids in which neurons, macroglia, microglia and vascularization are present. Finally, we debate the limitations of those models and possible future directions."}],"title":"Modeling cell-cell interactions in the brain using cerebral organoids","article_processing_charge":"No","external_id":{"isi":["000491646600033"],"pmid":["31521639"]},"author":[{"id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","first_name":"Bárbara","last_name":"Oliveira","full_name":"Oliveira, Bárbara"},{"first_name":"Aysan Çerağ","id":"365A65F8-F248-11E8-B48F-1D18A9856A87","last_name":"Yahya","full_name":"Yahya, Aysan Çerağ"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","last_name":"Novarino"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Oliveira, Bárbara, Aysan Çerağ Yahya, and Gaia Novarino. “Modeling Cell-Cell Interactions in the Brain Using Cerebral Organoids.” Brain Research. Elsevier, 2019. https://doi.org/10.1016/j.brainres.2019.146458.","ista":"Oliveira B, Yahya AÇ, Novarino G. 2019. Modeling cell-cell interactions in the brain using cerebral organoids. Brain Research. 1724, 146458.","mla":"Oliveira, Bárbara, et al. “Modeling Cell-Cell Interactions in the Brain Using Cerebral Organoids.” Brain Research, vol. 1724, 146458, Elsevier, 2019, doi:10.1016/j.brainres.2019.146458.","ama":"Oliveira B, Yahya AÇ, Novarino G. Modeling cell-cell interactions in the brain using cerebral organoids. Brain Research. 2019;1724. doi:10.1016/j.brainres.2019.146458","apa":"Oliveira, B., Yahya, A. Ç., & Novarino, G. (2019). Modeling cell-cell interactions in the brain using cerebral organoids. Brain Research. Elsevier. https://doi.org/10.1016/j.brainres.2019.146458","short":"B. Oliveira, A.Ç. Yahya, G. Novarino, Brain Research 1724 (2019).","ieee":"B. Oliveira, A. Ç. Yahya, and G. Novarino, “Modeling cell-cell interactions in the brain using cerebral organoids,” Brain Research, vol. 1724. Elsevier, 2019."},"article_number":"146458","date_created":"2019-09-22T22:00:35Z","doi":"10.1016/j.brainres.2019.146458","date_published":"2019-12-01T00:00:00Z","publication":"Brain Research","day":"01","year":"2019","isi":1,"quality_controlled":"1","publisher":"Elsevier"},{"date_published":"2019-09-12T00:00:00Z","doi":"10.6084/m9.figshare.9808772.v1","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"6898"}]},"date_created":"2021-07-27T14:09:11Z","year":"2019","day":"12","publisher":"Springer Nature","oa":1,"main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.9808772.v1","open_access":"1"}],"month":"09","abstract":[{"text":"OGs with putative pseudogenes by the number of affected genomes in different chlamydial species. Frameshift and nonsense mutations located less than 60 bp upstreamof the gene end or present in a single genome from the corresponding OG were excluded. (CSV 31 kb)","lang":"eng"}],"oa_version":"Published Version","author":[{"first_name":"Olga","full_name":"Sigalova, Olga","last_name":"Sigalova"},{"full_name":"Chaplin, Andrei","last_name":"Chaplin","first_name":"Andrei"},{"first_name":"Olga","id":"C4558D3C-6102-11E9-A62E-F418E6697425","orcid":"0000-0003-1006-6639","full_name":"Bochkareva, Olga","last_name":"Bochkareva"},{"first_name":"Pavel","last_name":"Shelyakin","full_name":"Shelyakin, Pavel"},{"last_name":"Filaretov","full_name":"Filaretov, Vsevolod","first_name":"Vsevolod"},{"last_name":"Akkuratov","full_name":"Akkuratov, Evgeny","first_name":"Evgeny"},{"first_name":"Valentina","last_name":"Burskaia","full_name":"Burskaia, Valentina"},{"first_name":"Mikhail S.","last_name":"Gelfand","full_name":"Gelfand, Mikhail S."}],"article_processing_charge":"No","department":[{"_id":"FyKo"}],"title":"Additional file 11 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction","citation":{"chicago":"Sigalova, Olga, Andrei Chaplin, Olga Bochkareva, Pavel Shelyakin, Vsevolod Filaretov, Evgeny Akkuratov, Valentina Burskaia, and Mikhail S. 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Gelfand, (2019)."},"date_updated":"2023-08-30T06:20:21Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","status":"public","_id":"9731"},{"type":"research_data_reference","status":"public","_id":"9783","article_processing_charge":"No","author":[{"first_name":"Olga M.","full_name":"Sigalova, Olga M.","last_name":"Sigalova"},{"first_name":"Andrei V.","last_name":"Chaplin","full_name":"Chaplin, Andrei V."},{"id":"C4558D3C-6102-11E9-A62E-F418E6697425","first_name":"Olga","last_name":"Bochkareva","full_name":"Bochkareva, Olga","orcid":"0000-0003-1006-6639"},{"first_name":"Pavel V.","last_name":"Shelyakin","full_name":"Shelyakin, Pavel V."},{"last_name":"Filaretov","full_name":"Filaretov, Vsevolod A.","first_name":"Vsevolod A."},{"first_name":"Evgeny E.","last_name":"Akkuratov","full_name":"Akkuratov, Evgeny E."},{"full_name":"Burskaia, Valentina","last_name":"Burskaia","first_name":"Valentina"},{"full_name":"Gelfand, Mikhail S.","last_name":"Gelfand","first_name":"Mikhail S."}],"title":"Additional file 10 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction","department":[{"_id":"FyKo"}],"date_updated":"2023-08-30T06:20:21Z","citation":{"chicago":"Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin, Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S. Gelfand. “Additional File 10 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” Springer Nature, 2019. https://doi.org/10.6084/m9.figshare.9808760.v1.","ista":"Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov EE, Burskaia V, Gelfand MS. 2019. Additional file 10 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction, Springer Nature, 10.6084/m9.figshare.9808760.v1.","mla":"Sigalova, Olga M., et al. Additional File 10 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction. Springer Nature, 2019, doi:10.6084/m9.figshare.9808760.v1.","ieee":"O. M. Sigalova et al., “Additional file 10 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.” Springer Nature, 2019.","short":"O.M. Sigalova, A.V. Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov, E.E. Akkuratov, V. Burskaia, M.S. Gelfand, (2019).","apa":"Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov, V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Additional file 10 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. Springer Nature. https://doi.org/10.6084/m9.figshare.9808760.v1","ama":"Sigalova OM, Chaplin AV, Bochkareva O, et al. 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(CSV 600 kb)"}],"oa_version":"Published Version","date_created":"2021-08-06T07:59:56Z","date_published":"2019-09-12T00:00:00Z","doi":"10.6084/m9.figshare.9808760.v1","related_material":{"record":[{"relation":"used_in_publication","id":"6898","status":"public"}]},"year":"2019","day":"12"},{"day":"12","year":"2019","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"6898"}]},"date_published":"2019-09-12T00:00:00Z","doi":"10.6084/m9.figshare.9808850.v1","date_created":"2021-08-12T07:58:15Z","oa_version":"Published Version","abstract":[{"text":"Frameshift and nonsense mutations near homopolymeric tracts of OG1 genes. Only 374 genes with typical length and domain composition were considered. (CSV 6 kb)","lang":"eng"}],"month":"09","publisher":"Springer Nature","oa":1,"main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.9808850.v1","open_access":"1"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","citation":{"mla":"Sigalova, Olga M., et al. 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Additional file 20 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. 2019. doi:10.6084/m9.figshare.9808850.v1","chicago":"Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin, Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S. Gelfand. “Additional File 20 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” Springer Nature, 2019. https://doi.org/10.6084/m9.figshare.9808850.v1.","ista":"Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov EE, Burskaia V, Gelfand MS. 2019. 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(CSV 7 kb)"}],"month":"09","oa":1,"main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.9808802.v1","open_access":"1"}],"publisher":"Springer Nature","day":"12","year":"2019","date_created":"2021-08-11T14:26:40Z","doi":"10.6084/m9.figshare.9808802.v1","date_published":"2019-09-12T00:00:00Z","related_material":{"record":[{"id":"6898","status":"public","relation":"used_in_publication"}]},"_id":"9890","status":"public","type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_updated":"2023-08-30T06:20:21Z","citation":{"apa":"Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov, V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Additional file 15 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. Springer Nature. https://doi.org/10.6084/m9.figshare.9808802.v1","ama":"Sigalova OM, Chaplin AV, Bochkareva O, et al. 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Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov, E.E. Akkuratov, V. Burskaia, M.S. Gelfand, (2019).","chicago":"Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin, Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S. Gelfand. “Additional File 17 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” Springer Nature, 2019. https://doi.org/10.6084/m9.figshare.9808820.v1.","ista":"Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov EE, Burskaia V, Gelfand MS. 2019. 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Sigalova, A.V. Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov, E.E. Akkuratov, V. Burskaia, M.S. Gelfand, (2019).","ieee":"O. M. Sigalova et al., “Additional file 1 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.” Springer Nature, 2019.","ama":"Sigalova OM, Chaplin AV, Bochkareva O, et al. Additional file 1 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. 2019. doi:10.6084/m9.figshare.9808841.v1","apa":"Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov, V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Additional file 1 of Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. Springer Nature. https://doi.org/10.6084/m9.figshare.9808841.v1","mla":"Sigalova, Olga M., et al. 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Gelfand. “Additional File 1 of Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” Springer Nature, 2019. https://doi.org/10.6084/m9.figshare.9808841.v1."},"date_updated":"2023-08-30T06:20:21Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","status":"public","_id":"9896","date_published":"2019-09-02T00:00:00Z","doi":"10.6084/m9.figshare.9808841.v1","related_material":{"record":[{"status":"public","id":"6898","relation":"used_in_publication"}]},"date_created":"2021-08-12T07:50:53Z","year":"2019","day":"02","publisher":"Springer Nature","main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.9808841.v1","open_access":"1"}],"oa":1,"month":"09","abstract":[{"text":"Summary of the analysed genomes. (CSV 24 kb)","lang":"eng"}],"oa_version":"Published Version"},{"file_date_updated":"2020-07-14T12:47:44Z","department":[{"_id":"CaHe"}],"date_updated":"2023-08-30T06:21:23Z","ddc":["570"],"type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","_id":"6899","volume":10,"issue":"1","publication_identifier":{"eissn":["20411723"]},"publication_status":"published","file":[{"checksum":"62c2512712e16d27c1797d318d14ba9f","file_id":"6926","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"2019_Nature_Bornhorst.pdf","date_created":"2019-10-01T11:18:50Z","file_size":3905793,"date_updated":"2020-07-14T12:47:44Z","creator":"kschuh"}],"language":[{"iso":"eng"}],"scopus_import":"1","month":"09","intvolume":" 10","abstract":[{"lang":"eng","text":"Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed."}],"oa_version":"Published Version","pmid":1,"author":[{"first_name":"Dorothee","full_name":"Bornhorst, Dorothee","last_name":"Bornhorst"},{"first_name":"Peng","id":"4AB6C7D0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5419-7756","full_name":"Xia, Peng","last_name":"Xia"},{"last_name":"Nakajima","full_name":"Nakajima, Hiroyuki","first_name":"Hiroyuki"},{"last_name":"Dingare","full_name":"Dingare, Chaitanya","first_name":"Chaitanya"},{"first_name":"Wiebke","full_name":"Herzog, Wiebke","last_name":"Herzog"},{"first_name":"Virginie","last_name":"Lecaudey","full_name":"Lecaudey, Virginie"},{"last_name":"Mochizuki","full_name":"Mochizuki, Naoki","first_name":"Naoki"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566"},{"last_name":"Yelon","full_name":"Yelon, Deborah","first_name":"Deborah"},{"last_name":"Abdelilah-Seyfried","full_name":"Abdelilah-Seyfried, Salim","first_name":"Salim"}],"external_id":{"isi":["000485216800009"],"pmid":["31511517"]},"article_processing_charge":"No","title":"Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions","citation":{"chicago":"Bornhorst, Dorothee, Peng Xia, Hiroyuki Nakajima, Chaitanya Dingare, Wiebke Herzog, Virginie Lecaudey, Naoki Mochizuki, Carl-Philipp J Heisenberg, Deborah Yelon, and Salim Abdelilah-Seyfried. “Biomechanical Signaling within the Developing Zebrafish Heart Attunes Endocardial Growth to Myocardial Chamber Dimensions.” Nature Communications. Nature Publishing Group, 2019. https://doi.org/10.1038/s41467-019-12068-x.","ista":"Bornhorst D, Xia P, Nakajima H, Dingare C, Herzog W, Lecaudey V, Mochizuki N, Heisenberg C-PJ, Yelon D, Abdelilah-Seyfried S. 2019. Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10(1), 4113.","mla":"Bornhorst, Dorothee, et al. “Biomechanical Signaling within the Developing Zebrafish Heart Attunes Endocardial Growth to Myocardial Chamber Dimensions.” Nature Communications, vol. 10, no. 1, Nature Publishing Group, 2019, p. 4113, doi:10.1038/s41467-019-12068-x.","ama":"Bornhorst D, Xia P, Nakajima H, et al. Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 2019;10(1):4113. doi:10.1038/s41467-019-12068-x","apa":"Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., … Abdelilah-Seyfried, S. (2019). Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-019-12068-x","ieee":"D. Bornhorst et al., “Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions,” Nature communications, vol. 10, no. 1. Nature Publishing Group, p. 4113, 2019.","short":"D. Bornhorst, P. Xia, H. Nakajima, C. Dingare, W. Herzog, V. Lecaudey, N. Mochizuki, C.-P.J. Heisenberg, D. Yelon, S. Abdelilah-Seyfried, Nature Communications 10 (2019) 4113."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"4113","date_published":"2019-09-11T00:00:00Z","doi":"10.1038/s41467-019-12068-x","date_created":"2019-09-22T22:00:37Z","isi":1,"has_accepted_license":"1","year":"2019","day":"11","publication":"Nature communications","quality_controlled":"1","publisher":"Nature Publishing Group","oa":1},{"article_processing_charge":"No","external_id":{"isi":["000485256100001"]},"author":[{"first_name":"Olga M.","full_name":"Sigalova, Olga M.","last_name":"Sigalova"},{"first_name":"Andrei V.","last_name":"Chaplin","full_name":"Chaplin, Andrei V."},{"last_name":"Bochkareva","full_name":"Bochkareva, Olga","orcid":"0000-0003-1006-6639","first_name":"Olga","id":"C4558D3C-6102-11E9-A62E-F418E6697425"},{"full_name":"Shelyakin, Pavel V.","last_name":"Shelyakin","first_name":"Pavel V."},{"full_name":"Filaretov, Vsevolod A.","last_name":"Filaretov","first_name":"Vsevolod A."},{"last_name":"Akkuratov","full_name":"Akkuratov, Evgeny E.","first_name":"Evgeny E."},{"last_name":"Burskaia","full_name":"Burskaia, Valentina","first_name":"Valentina"},{"last_name":"Gelfand","full_name":"Gelfand, Mikhail S.","first_name":"Mikhail S."}],"title":"Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction","citation":{"mla":"Sigalova, Olga M., et al. “Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” BMC Genomics, vol. 20, no. 1, 710, BioMed Central, 2019, doi:10.1186/s12864-019-6059-5.","short":"O.M. Sigalova, A.V. Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov, E.E. Akkuratov, V. Burskaia, M.S. Gelfand, BMC Genomics 20 (2019).","ieee":"O. M. Sigalova et al., “Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction,” BMC Genomics, vol. 20, no. 1. BioMed Central, 2019.","apa":"Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov, V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. BMC Genomics. BioMed Central. https://doi.org/10.1186/s12864-019-6059-5","ama":"Sigalova OM, Chaplin AV, Bochkareva O, et al. Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. BMC Genomics. 2019;20(1). doi:10.1186/s12864-019-6059-5","chicago":"Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin, Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S. Gelfand. “Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation and Selective Pressure to Genome Reduction.” BMC Genomics. BioMed Central, 2019. https://doi.org/10.1186/s12864-019-6059-5.","ista":"Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov EE, Burskaia V, Gelfand MS. 2019. Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction. BMC Genomics. 20(1), 710."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_number":"710","date_created":"2019-09-22T22:00:36Z","date_published":"2019-09-12T00:00:00Z","doi":"10.1186/s12864-019-6059-5","year":"2019","has_accepted_license":"1","isi":1,"publication":"BMC Genomics","day":"12","oa":1,"quality_controlled":"1","publisher":"BioMed Central","department":[{"_id":"FyKo"}],"file_date_updated":"2020-07-14T12:47:44Z","date_updated":"2023-08-30T06:20:22Z","ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","status":"public","_id":"6898","issue":"1","volume":20,"related_material":{"record":[{"relation":"research_data","status":"public","id":"9731"},{"status":"public","id":"9783","relation":"research_data"},{"status":"public","id":"9890","relation":"research_data"},{"status":"public","id":"9892","relation":"research_data"},{"relation":"research_data","id":"9893","status":"public"},{"relation":"research_data","status":"public","id":"9894"},{"relation":"research_data","id":"9895","status":"public"},{"relation":"research_data","status":"public","id":"9896"},{"relation":"research_data","status":"public","id":"9897"},{"relation":"research_data","status":"public","id":"9898"},{"relation":"research_data","id":"9899","status":"public"},{"relation":"research_data","status":"public","id":"9900"},{"relation":"research_data","id":"9901","status":"public"}]},"publication_status":"published","publication_identifier":{"eissn":["14712164"]},"language":[{"iso":"eng"}],"file":[{"file_size":4157175,"date_updated":"2020-07-14T12:47:44Z","creator":"kschuh","file_name":"2019_BioMed_Sigalova.pdf","date_created":"2019-10-01T10:33:17Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"6924","checksum":"b798773c5823012d31c812c9f7975da2"}],"scopus_import":"1","intvolume":" 20","month":"09","abstract":[{"lang":"eng","text":"Background\r\n\r\nChlamydia are ancient intracellular pathogens with reduced, though strikingly conserved genome. Despite their parasitic lifestyle and isolated intracellular environment, these bacteria managed to avoid accumulation of deleterious mutations leading to subsequent genome degradation characteristic for many parasitic bacteria.\r\nResults\r\n\r\nWe report pan-genomic analysis of sixteen species from genus Chlamydia including identification and functional annotation of orthologous genes, and characterization of gene gains, losses, and rearrangements. We demonstrate the overall genome stability of these bacteria as indicated by a large fraction of common genes with conserved genomic locations. On the other hand, extreme evolvability is confined to several paralogous gene families such as polymorphic membrane proteins and phospholipase D, and likely is caused by the pressure from the host immune system.\r\nConclusions\r\n\r\nThis combination of a large, conserved core genome and a small, evolvable periphery likely reflect the balance between the selective pressure towards genome reduction and the need to adapt to escape from the host immunity."}],"oa_version":"Published Version"}]