[{"day":"14","publication":"Journal de Theorie des Nombres de Bordeaux","publication_status":"published","year":"2013","date_published":"2013-05-14T00:00:00Z","issue":"1","volume":26,"doi":"10.5802/jtnb.857","date_created":"2018-12-11T11:45:26Z","page":"25 - 44","abstract":[{"text":"We study the density of varieties in a certain family which do not satisfy the Hasse principle. This work relies on results recently obtained by Colliot-Thélène [3].","lang":"eng"}],"month":"05","intvolume":" 26","quality_controlled":0,"publisher":"Universite de Bordeaux I","extern":1,"citation":{"chicago":"De La Bretèche, Régis, and Timothy D Browning. “Counter Examples to the Hasse Principle among Certain Coflasque Tori.” Journal de Theorie Des Nombres de Bordeaux. Universite de Bordeaux I, 2013. https://doi.org/10.5802/jtnb.857.","ista":"De La Bretèche R, Browning TD. 2013. Counter examples to the Hasse principle among certain coflasque tori. Journal de Theorie des Nombres de Bordeaux. 26(1), 25–44.","mla":"De La Bretèche, Régis, and Timothy D. Browning. “Counter Examples to the Hasse Principle among Certain Coflasque Tori.” Journal de Theorie Des Nombres de Bordeaux, vol. 26, no. 1, Universite de Bordeaux I, 2013, pp. 25–44, doi:10.5802/jtnb.857.","ieee":"R. De La Bretèche and T. D. Browning, “Counter examples to the Hasse principle among certain coflasque tori,” Journal de Theorie des Nombres de Bordeaux, vol. 26, no. 1. Universite de Bordeaux I, pp. 25–44, 2013.","short":"R. De La Bretèche, T.D. Browning, Journal de Theorie Des Nombres de Bordeaux 26 (2013) 25–44.","apa":"De La Bretèche, R., & Browning, T. D. (2013). Counter examples to the Hasse principle among certain coflasque tori. Journal de Theorie Des Nombres de Bordeaux. Universite de Bordeaux I. https://doi.org/10.5802/jtnb.857","ama":"De La Bretèche R, Browning TD. Counter examples to the Hasse principle among certain coflasque tori. Journal de Theorie des Nombres de Bordeaux. 2013;26(1):25-44. doi:10.5802/jtnb.857"},"date_updated":"2021-01-12T06:57:55Z","title":"Counter examples to the Hasse principle among certain coflasque tori","author":[{"last_name":"De La Bretèche","full_name":"de la Bretèche, Régis","first_name":"Régis"},{"first_name":"Timothy D","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","full_name":"Timothy Browning","last_name":"Browning"}],"publist_id":"7651","_id":"251","status":"public","type":"journal_article"},{"oa":1,"quality_controlled":"1","publisher":"Springer","acknowledgement":"ERC Grant QUALITY. ","page":"15 - 27","date_created":"2018-12-11T11:58:08Z","doi":"10.1007/978-3-642-39212-2_3","date_published":"2013-07-01T00:00:00Z","year":"2013","has_accepted_license":"1","day":"01","project":[{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"S 11407_N23","name":"Rigorous Systems Engineering"},{"grant_number":"267989","name":"Quantitative Reactive Modeling","call_identifier":"FP7","_id":"25EE3708-B435-11E9-9278-68D0E5697425"}],"article_processing_charge":"No","publist_id":"4384","author":[{"first_name":"Shaull","last_name":"Almagor","full_name":"Almagor, Shaull"},{"full_name":"Boker, Udi","last_name":"Boker","first_name":"Udi","id":"31E297B6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Orna","last_name":"Kupferman","full_name":"Kupferman, Orna"}],"title":"Formalizing and reasoning about quality","citation":{"ista":"Almagor S, Boker U, Kupferman O. 2013. Formalizing and reasoning about quality. 7966(Part 2), 15–27.","chicago":"Almagor, Shaull, Udi Boker, and Orna Kupferman. “Formalizing and Reasoning about Quality.” Lecture Notes in Computer Science. Springer, 2013. https://doi.org/10.1007/978-3-642-39212-2_3.","apa":"Almagor, S., Boker, U., & Kupferman, O. (2013). Formalizing and reasoning about quality. Presented at the ICALP: Automata, Languages and Programming, Riga, Latvia: Springer. https://doi.org/10.1007/978-3-642-39212-2_3","ama":"Almagor S, Boker U, Kupferman O. Formalizing and reasoning about quality. 2013;7966(Part 2):15-27. doi:10.1007/978-3-642-39212-2_3","short":"S. Almagor, U. Boker, O. Kupferman, 7966 (2013) 15–27.","ieee":"S. Almagor, U. Boker, and O. Kupferman, “Formalizing and reasoning about quality,” vol. 7966, no. Part 2. Springer, pp. 15–27, 2013.","mla":"Almagor, Shaull, et al. Formalizing and Reasoning about Quality. Vol. 7966, no. Part 2, Springer, 2013, pp. 15–27, doi:10.1007/978-3-642-39212-2_3."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","alternative_title":["LNCS"],"scopus_import":1,"intvolume":" 7966","month":"07","abstract":[{"lang":"eng","text":"Traditional formal methods are based on a Boolean satisfaction notion: a reactive system satisfies, or not, a given specification. We generalize formal methods to also address the quality of systems. As an adequate specification formalism we introduce the linear temporal logic LTL[F]. The satisfaction value of an LTL[F] formula is a number between 0 and 1, describing the quality of the satisfaction. The logic generalizes traditional LTL by augmenting it with a (parameterized) set F of arbitrary functions over the interval [0,1]. For example, F may contain the maximum or minimum between the satisfaction values of subformulas, their product, and their average. The classical decision problems in formal methods, such as satisfiability, model checking, and synthesis, are generalized to search and optimization problems in the quantitative setting. For example, model checking asks for the quality in which a specification is satisfied, and synthesis returns a system satisfying the specification with the highest quality. Reasoning about quality gives rise to other natural questions, like the distance between specifications. We formalize these basic questions and study them for LTL[F]. By extending the automata-theoretic approach for LTL to a setting that takes quality into an account, we are able to solve the above problems and show that reasoning about LTL[F] has roughly the same complexity as reasoning about traditional LTL."}],"oa_version":"Submitted Version","ec_funded":1,"volume":7966,"issue":"Part 2","publication_status":"published","language":[{"iso":"eng"}],"file":[{"date_created":"2020-05-15T11:16:12Z","file_name":"2013_ICALP_Almagor.pdf","date_updated":"2020-07-14T12:45:42Z","file_size":363031,"creator":"dernst","checksum":"85afbf6c18a2c7e377c52c9410e2d824","file_id":"7860","content_type":"application/pdf","access_level":"open_access","relation":"main_file"}],"conference":{"name":"ICALP: Automata, Languages and Programming","end_date":"2013-07-12","location":"Riga, Latvia","start_date":"2013-07-08"},"type":"conference","status":"public","_id":"2517","series_title":"Lecture Notes in Computer Science","file_date_updated":"2020-07-14T12:45:42Z","department":[{"_id":"ToHe"}],"date_updated":"2020-08-11T10:09:47Z","ddc":["000"]},{"department":[{"_id":"VlKo"}],"date_updated":"2023-02-23T10:35:42Z","type":"conference","conference":{"name":"ICALP: Automata, Languages and Programming","start_date":"2013-07-08","end_date":"2013-07-12","location":"Riga, Latvia"},"status":"public","_id":"2518","issue":"1","volume":7965,"related_material":{"record":[{"id":"2271","status":"public","relation":"later_version"}]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":1,"alternative_title":["LNCS"],"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1207.7213"}],"month":"07","intvolume":" 7965","abstract":[{"lang":"eng","text":"A class of valued constraint satisfaction problems (VCSPs) is characterised by a valued constraint language, a fixed set of cost functions on a finite domain. An instance of the problem is specified by a sum of cost functions from the language with the goal to minimise the sum. We study which classes of finite-valued languages can be solved exactly by the basic linear programming relaxation (BLP). Thapper and Živný showed [20] that if BLP solves the language then the language admits a binary commutative fractional polymorphism. We prove that the converse is also true. This leads to a necessary and a sufficient condition which can be checked in polynomial time for a given language. In contrast, the previous necessary and sufficient condition due to [20] involved infinitely many inequalities. More recently, Thapper and Živný [21] showed (using, in particular, a technique introduced in this paper) that core languages that do not satisfy our condition are NP-hard. Taken together, these results imply that a finite-valued language can either be solved using Linear Programming or is NP-hard."}],"oa_version":"Preprint","author":[{"last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir"}],"publist_id":"4383","external_id":{"arxiv":["1207.7213"]},"title":"The power of linear programming for finite-valued CSPs: A constructive characterization","citation":{"chicago":"Kolmogorov, Vladimir. “The Power of Linear Programming for Finite-Valued CSPs: A Constructive Characterization,” 7965:625–36. Springer, 2013. https://doi.org/10.1007/978-3-642-39206-1_53.","ista":"Kolmogorov V. 2013. The power of linear programming for finite-valued CSPs: A constructive characterization. ICALP: Automata, Languages and Programming, LNCS, vol. 7965, 625–636.","mla":"Kolmogorov, Vladimir. The Power of Linear Programming for Finite-Valued CSPs: A Constructive Characterization. Vol. 7965, no. 1, Springer, 2013, pp. 625–36, doi:10.1007/978-3-642-39206-1_53.","ieee":"V. Kolmogorov, “The power of linear programming for finite-valued CSPs: A constructive characterization,” presented at the ICALP: Automata, Languages and Programming, Riga, Latvia, 2013, vol. 7965, no. 1, pp. 625–636.","short":"V. Kolmogorov, in:, Springer, 2013, pp. 625–636.","ama":"Kolmogorov V. The power of linear programming for finite-valued CSPs: A constructive characterization. In: Vol 7965. Springer; 2013:625-636. doi:10.1007/978-3-642-39206-1_53","apa":"Kolmogorov, V. (2013). The power of linear programming for finite-valued CSPs: A constructive characterization (Vol. 7965, pp. 625–636). Presented at the ICALP: Automata, Languages and Programming, Riga, Latvia: Springer. https://doi.org/10.1007/978-3-642-39206-1_53"},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","page":"625 - 636","date_published":"2013-07-01T00:00:00Z","doi":"10.1007/978-3-642-39206-1_53","date_created":"2018-12-11T11:58:08Z","year":"2013","day":"01","publisher":"Springer","quality_controlled":"1","oa":1},{"publication_status":"published","year":"2013","publication":"IEEE Transactions on Pattern Analysis and Machine Intelligence","language":[{"iso":"eng"}],"day":"30","page":"453 - 465","date_created":"2018-12-11T11:58:08Z","doi":"10.1109/TPAMI.2013.140","issue":"3","date_published":"2013-07-30T00:00:00Z","volume":36,"abstract":[{"text":"We study the problem of object recognition for categories for which we have no training examples, a task also called zero-data or zero-shot learning. This situation has hardly been studied in computer vision research, even though it occurs frequently: the world contains tens of thousands of different object classes and for only few of them image collections have been formed and suitably annotated. To tackle the problem we introduce attribute-based classification: objects are identified based on a high-level description that is phrased in terms of semantic attributes, such as the object's color or shape. Because the identification of each such property transcends the specific learning task at hand, the attribute classifiers can be pre-learned independently, e.g. from existing image datasets unrelated to the current task. Afterwards, new classes can be detected based on their attribute representation, without the need for a new training phase. In this paper we also introduce a new dataset, Animals with Attributes, of over 30,000 images of 50 animal classes, annotated with 85 semantic attributes. Extensive experiments on this and two more datasets show that attribute-based classification indeed is able to categorize images without access to any training images of the target classes.","lang":"eng"}],"oa_version":"None","publisher":"IEEE","scopus_import":1,"quality_controlled":"1","intvolume":" 36","month":"07","citation":{"ista":"Lampert C, Nickisch H, Harmeling S. 2013. Attribute-based classification for zero-shot learning of object categories. IEEE Transactions on Pattern Analysis and Machine Intelligence. 36(3), 453–465.","chicago":"Lampert, Christoph, Hannes Nickisch, and Stefan Harmeling. “Attribute-Based Classification for Zero-Shot Learning of Object Categories.” IEEE Transactions on Pattern Analysis and Machine Intelligence. IEEE, 2013. https://doi.org/10.1109/TPAMI.2013.140.","apa":"Lampert, C., Nickisch, H., & Harmeling, S. (2013). Attribute-based classification for zero-shot learning of object categories. IEEE Transactions on Pattern Analysis and Machine Intelligence. IEEE. https://doi.org/10.1109/TPAMI.2013.140","ama":"Lampert C, Nickisch H, Harmeling S. Attribute-based classification for zero-shot learning of object categories. IEEE Transactions on Pattern Analysis and Machine Intelligence. 2013;36(3):453-465. doi:10.1109/TPAMI.2013.140","ieee":"C. Lampert, H. Nickisch, and S. Harmeling, “Attribute-based classification for zero-shot learning of object categories,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 36, no. 3. IEEE, pp. 453–465, 2013.","short":"C. Lampert, H. Nickisch, S. Harmeling, IEEE Transactions on Pattern Analysis and Machine Intelligence 36 (2013) 453–465.","mla":"Lampert, Christoph, et al. “Attribute-Based Classification for Zero-Shot Learning of Object Categories.” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 36, no. 3, IEEE, 2013, pp. 453–65, doi:10.1109/TPAMI.2013.140."},"date_updated":"2021-01-12T06:57:58Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Lampert","full_name":"Lampert, Christoph","orcid":"0000-0001-8622-7887","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph"},{"full_name":"Nickisch, Hannes","last_name":"Nickisch","first_name":"Hannes"},{"first_name":"Stefan","last_name":"Harmeling","full_name":"Harmeling, Stefan"}],"publist_id":"4385","title":"Attribute-based classification for zero-shot learning of object categories","department":[{"_id":"ChLa"}],"_id":"2516","type":"journal_article","status":"public"},{"ddc":["000"],"date_updated":"2023-02-23T10:46:36Z","department":[{"_id":"ChLa"}],"file_date_updated":"2020-07-14T12:45:42Z","_id":"2520","pubrep_id":"137","status":"public","conference":{"end_date":"2013-07-15","location":"Bellevue, WA, United States","start_date":"2013-07-11","name":"UAI: Uncertainty in Artificial Intelligence"},"type":"conference","language":[{"iso":"eng"}],"file":[{"file_id":"5134","checksum":"325f20c4b926bd74d39006b97df572bd","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"IST-2013-137-v1+1_QuaShaKnoGha13.pdf","date_created":"2018-12-12T10:15:16Z","file_size":1117100,"date_updated":"2020-07-14T12:45:42Z","creator":"system"}],"publication_status":"published","publication_identifier":{"isbn":["9780974903996"]},"oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"We propose a probabilistic model to infer supervised latent variables in\r\nthe Hamming space from observed data. Our model allows simultaneous\r\ninference of the number of binary latent variables, and their values. The\r\nlatent variables preserve neighbourhood structure of the data in a sense\r\nthat objects in the same semantic concept have similar latent values, and\r\nobjects in different concepts have dissimilar latent values. We formulate\r\nthe supervised infinite latent variable problem based on an intuitive\r\nprinciple of pulling objects together if they are of the same type, and\r\npushing them apart if they are not. We then combine this principle with a\r\nflexible Indian Buffet Process prior on the latent variables. We show that\r\nthe inferred supervised latent variables can be directly used to perform a\r\nnearest neighbour search for the purpose of retrieval. We introduce a new\r\napplication of dynamically extending hash codes, and show how to\r\neffectively couple the structure of the hash codes with continuously\r\ngrowing structure of the neighbourhood preserving infinite latent feature\r\nspace."}],"month":"07","scopus_import":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Quadrianto, Novi, et al. “The Supervised IBP: Neighbourhood Preserving Infinite Latent Feature Models.” Proceedings of the 29th Conference Uncertainty in Artificial Intelligence, AUAI Press, 2013, pp. 527–36.","short":"N. Quadrianto, V. Sharmanska, D. Knowles, Z. Ghahramani, in:, Proceedings of the 29th Conference Uncertainty in Artificial Intelligence, AUAI Press, 2013, pp. 527–536.","ieee":"N. Quadrianto, V. Sharmanska, D. Knowles, and Z. Ghahramani, “The supervised IBP: Neighbourhood preserving infinite latent feature models,” in Proceedings of the 29th conference uncertainty in Artificial Intelligence, Bellevue, WA, United States, 2013, pp. 527–536.","ama":"Quadrianto N, Sharmanska V, Knowles D, Ghahramani Z. The supervised IBP: Neighbourhood preserving infinite latent feature models. In: Proceedings of the 29th Conference Uncertainty in Artificial Intelligence. AUAI Press; 2013:527-536.","apa":"Quadrianto, N., Sharmanska, V., Knowles, D., & Ghahramani, Z. (2013). The supervised IBP: Neighbourhood preserving infinite latent feature models. In Proceedings of the 29th conference uncertainty in Artificial Intelligence (pp. 527–536). Bellevue, WA, United States: AUAI Press.","chicago":"Quadrianto, Novi, Viktoriia Sharmanska, David Knowles, and Zoubin Ghahramani. “The Supervised IBP: Neighbourhood Preserving Infinite Latent Feature Models.” In Proceedings of the 29th Conference Uncertainty in Artificial Intelligence, 527–36. AUAI Press, 2013.","ista":"Quadrianto N, Sharmanska V, Knowles D, Ghahramani Z. 2013. The supervised IBP: Neighbourhood preserving infinite latent feature models. Proceedings of the 29th conference uncertainty in Artificial Intelligence. UAI: Uncertainty in Artificial Intelligence, 527–536."},"title":"The supervised IBP: Neighbourhood preserving infinite latent feature models","publist_id":"4381","author":[{"first_name":"Novi","full_name":"Quadrianto, Novi","last_name":"Quadrianto"},{"first_name":"Viktoriia","id":"2EA6D09E-F248-11E8-B48F-1D18A9856A87","last_name":"Sharmanska","orcid":"0000-0003-0192-9308","full_name":"Sharmanska, Viktoriia"},{"first_name":"David","full_name":"Knowles, David","last_name":"Knowles"},{"first_name":"Zoubin","full_name":"Ghahramani, Zoubin","last_name":"Ghahramani"}],"publication":"Proceedings of the 29th conference uncertainty in Artificial Intelligence","day":"11","year":"2013","has_accepted_license":"1","date_created":"2018-12-11T11:58:09Z","date_published":"2013-07-11T00:00:00Z","page":"527 - 536","oa":1,"publisher":"AUAI Press","quality_controlled":"1"},{"month":"09","intvolume":" 60","quality_controlled":0,"publisher":"Unknown","doi":"10.1112/S0025579313000132","volume":60,"date_published":"2013-09-06T00:00:00Z","issue":"1","date_created":"2018-12-11T11:45:27Z","page":"101 - 107","day":"06","publication":"Mathematika","year":"2013","publication_status":"published","status":"public","type":"journal_article","_id":"253","title":"Counting rational points on cubic hypersurfaces: Corrigendum","author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","first_name":"Timothy D","orcid":"0000-0002-8314-0177","full_name":"Timothy Browning","last_name":"Browning"}],"publist_id":"7649","extern":1,"date_updated":"2021-01-12T06:58:03Z","citation":{"ieee":"T. D. Browning, “Counting rational points on cubic hypersurfaces: Corrigendum,” Mathematika, vol. 60, no. 1. Unknown, pp. 101–107, 2013.","short":"T.D. Browning, Mathematika 60 (2013) 101–107.","ama":"Browning TD. Counting rational points on cubic hypersurfaces: Corrigendum. Mathematika. 2013;60(1):101-107. doi:10.1112/S0025579313000132","apa":"Browning, T. D. (2013). Counting rational points on cubic hypersurfaces: Corrigendum. Mathematika. Unknown. https://doi.org/10.1112/S0025579313000132","mla":"Browning, Timothy D. “Counting Rational Points on Cubic Hypersurfaces: Corrigendum.” Mathematika, vol. 60, no. 1, Unknown, 2013, pp. 101–07, doi:10.1112/S0025579313000132.","ista":"Browning TD. 2013. Counting rational points on cubic hypersurfaces: Corrigendum. Mathematika. 60(1), 101–107.","chicago":"Browning, Timothy D. “Counting Rational Points on Cubic Hypersurfaces: Corrigendum.” Mathematika. Unknown, 2013. https://doi.org/10.1112/S0025579313000132."}},{"_id":"2692","status":"public","type":"journal_article","extern":1,"date_updated":"2021-01-12T06:59:05Z","citation":{"short":"A. Dobi, S. Sartori, D. Busti, H. Van Der Putten, N. Singewald, R. Shigemoto, F. Ferraguti, Neuropharmacology 66 (2013) 274–289.","ieee":"A. Dobi et al., “Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice,” Neuropharmacology, vol. 66. Elsevier, pp. 274–289, 2013.","apa":"Dobi, A., Sartori, S., Busti, D., Van Der Putten, H., Singewald, N., Shigemoto, R., & Ferraguti, F. (2013). Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. Elsevier. https://doi.org/10.1016/j.neuropharm.2012.05.025","ama":"Dobi A, Sartori S, Busti D, et al. Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. 2013;66:274-289. doi:10.1016/j.neuropharm.2012.05.025","mla":"Dobi, Alice, et al. “Neural Substrates for the Distinct Effects of Presynaptic Group III Metabotropic Glutamate Receptors on Extinction of Contextual Fear Conditioning in Mice.” Neuropharmacology, vol. 66, Elsevier, 2013, pp. 274–89, doi:10.1016/j.neuropharm.2012.05.025.","ista":"Dobi A, Sartori S, Busti D, Van Der Putten H, Singewald N, Shigemoto R, Ferraguti F. 2013. Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. 66, 274–289.","chicago":"Dobi, Alice, Simone Sartori, Daniela Busti, Herman Van Der Putten, Nicolas Singewald, Ryuichi Shigemoto, and Francesco Ferraguti. “Neural Substrates for the Distinct Effects of Presynaptic Group III Metabotropic Glutamate Receptors on Extinction of Contextual Fear Conditioning in Mice.” Neuropharmacology. Elsevier, 2013. https://doi.org/10.1016/j.neuropharm.2012.05.025."},"title":"Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice","author":[{"first_name":"Alice","last_name":"Dobi","full_name":"Dobi, Alice"},{"full_name":"Sartori, Simone B","last_name":"Sartori","first_name":"Simone"},{"last_name":"Busti","full_name":"Busti, Daniela","first_name":"Daniela"},{"full_name":"Van Der Putten, Herman V","last_name":"Van Der Putten","first_name":"Herman"},{"first_name":"Nicolas","last_name":"Singewald","full_name":"Singewald, Nicolas"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Francesco","last_name":"Ferraguti","full_name":"Ferraguti, Francesco"}],"publist_id":"4205","abstract":[{"text":"The group III metabotropic glutamate (mGlu) receptors mGlu7 and mGlu8 are receiving increased attention as potential novel therapeutic targets for anxiety disorders. The effects mediated by these receptors appear to result from a complex interplay of facilitatory and inhibitory actions at different brain sites in the anxiety/fear circuits. To better understand the effect of mGlu7 and mGlu8 receptors on extinction of contextual fear and their critical sites of action in the fear networks, we focused on the amygdala. Direct injection into the basolateral complex of the amygdala of the mGlu7 receptor agonist AMN082 facilitated extinction, whereas the mGlu8 receptor agonist (S)-3,4-DCPG sustained freezing during the extinction acquisition trial. We also determined at the ultrastructural level the synaptic distribution of these receptors in the basal nucleus (BA) and intercalated cell clusters (ITCs) of the amygdala. Both areas are thought to exert key roles in fear extinction. We demonstrate that mGlu7 and mGlu8 receptors are located in different presynaptic terminals forming both asymmetric and symmetric synapses, and that they preferentially target neurons expressing mGlu1α receptors mostly located around ITCs. In addition we show that mGlu7 and mGlu8 receptors were segregated to different inputs to a significant extent. In particular, mGlu7a receptors were primarily onto glutamatergic afferents arising from the BA or midline thalamic nuclei, but not the medial prefrontal cortex (mPFC), as revealed by combined anterograde tracing and pre-embedding electron microscopy. On the other hand, mGlu8a showed a more restricted distribution in the BA and appeared absent from thalamic, mPFC and intrinsic inputs. This segregation of mGlu7 and mGlu8 receptors in different neuronal pathways of the fear circuit might explain the distinct effects on fear extinction training observed with mGlu7 and mGlu8 receptor agonists.","lang":"eng"}],"intvolume":" 66","month":"03","quality_controlled":0,"publisher":"Elsevier","publication":"Neuropharmacology","day":"01","year":"2013","publication_status":"published","date_created":"2018-12-11T11:59:06Z","volume":66,"doi":"10.1016/j.neuropharm.2012.05.025","date_published":"2013-03-01T00:00:00Z","page":"274 - 289"},{"extern":1,"citation":{"mla":"Indriati, Dwi, et al. “Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Coclustering with Calcium-Activated Potassium Channels.” Journal of Neuroscience, vol. 33, no. 8, Society for Neuroscience, 2013, pp. 3668–78, doi:10.1523/JNEUROSCI.2921-12.2013.","apa":"Indriati, D., Kamasawa, N., Matsui, K., Meredith, A., Watanabe, M., & Shigemoto, R. (2013). Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.2921-12.2013","ama":"Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels. Journal of Neuroscience. 2013;33(8):3668-3678. doi:10.1523/JNEUROSCI.2921-12.2013","ieee":"D. Indriati, N. Kamasawa, K. Matsui, A. Meredith, M. Watanabe, and R. Shigemoto, “Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels,” Journal of Neuroscience, vol. 33, no. 8. Society for Neuroscience, pp. 3668–3678, 2013.","short":"D. Indriati, N. Kamasawa, K. Matsui, A. Meredith, M. Watanabe, R. Shigemoto, Journal of Neuroscience 33 (2013) 3668–3678.","chicago":"Indriati, Dwi, Naomi Kamasawa, Ko Matsui, Andrea Meredith, Masahiko Watanabe, and Ryuichi Shigemoto. “Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Coclustering with Calcium-Activated Potassium Channels.” Journal of Neuroscience. Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.2921-12.2013.","ista":"Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. 2013. Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels. Journal of Neuroscience. 33(8), 3668–3678."},"date_updated":"2021-01-12T06:59:05Z","title":"Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels","publist_id":"4206","author":[{"first_name":"Dwi","last_name":"Indriati","full_name":"Indriati, Dwi Wahyu"},{"first_name":"Naomi","last_name":"Kamasawa","full_name":"Kamasawa, Naomi"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"},{"first_name":"Andrea","full_name":"Meredith, Andrea L","last_name":"Meredith"},{"first_name":"Masahiko","last_name":"Watanabe","full_name":"Watanabe, Masahiko"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto"}],"_id":"2691","status":"public","type":"journal_article","publication":"Journal of Neuroscience","day":"20","year":"2013","publication_status":"published","date_created":"2018-12-11T11:59:05Z","doi":"10.1523/JNEUROSCI.2921-12.2013","issue":"8","date_published":"2013-02-20T00:00:00Z","volume":33,"page":"3668 - 3678","abstract":[{"text":"P/Q-type voltage-dependent calcium channels play key roles in transmitter release, integration of dendritic signals, generation of dendritic spikes, and gene expression. High intracellular calcium concentration transient produced by these channels is restricted to tens to hundreds of nanometers from the channels. Therefore, precise localization of these channels along the plasma membrane was long sought to decipher how each neuronal cell function is controlled. Here, we analyzed the distribution of Cav2.1 subunit of the P/Q-type channel using highly sensitive SDS-digested freeze-fracture replica labeling in the rat cerebellar Purkinje cells. The labeling efficiency was such that the number of immunogold particles in each parallel fiber active zone was comparable to that of functional channels calculated from previous reports. Two distinct patterns of Cav2.1 distribution, scattered and clustered, were found in Purkinje cells. The scattered Cav2.1 had a somatodendritic gradient with the density of immunogold particles increasing 2.5-fold from soma to distal dendrites. The other population with 74-fold higher density than the scattered particles was found within clusters of intramembrane particles on the P-face of soma and primary dendrites. Both populations of Cav2.1 were found as early as P3 and increased in the second postnatal week to a mature level. Using double immunogold labeling, we found that virtually all of the Cav2.1 clusters were colocalized with two types of calcium-activated potassium channels, BK and SK2, with the nearest neighbor distance of 40∼nm. Calcium nanodomain created by the opening of Cav2.1 channels likely activates the two channels that limit the extent of depolarization.","lang":"eng"}],"intvolume":" 33","month":"02","publisher":"Society for Neuroscience","quality_controlled":0},{"type":"journal_article","status":"public","_id":"2690","publist_id":"4207","author":[{"first_name":"Timotheus","full_name":"Budisantoso, Timotheus","last_name":"Budisantoso"},{"last_name":"Harada","orcid":"0000-0001-7429-7896","full_name":"Harumi Harada","first_name":"Harumi","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kamasawa","full_name":"Kamasawa, Naomi","first_name":"Naomi"},{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"}],"title":"Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held","date_updated":"2021-01-12T06:59:04Z","citation":{"apa":"Budisantoso, T., Harada, H., Kamasawa, N., Fukazawa, Y., Shigemoto, R., & Matsui, K. (2013). Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2012.241398","ama":"Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R, Matsui K. Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held. Journal of Physiology. 2013;591(1):219-239. doi:10.1113/jphysiol.2012.241398","ieee":"T. Budisantoso, H. Harada, N. Kamasawa, Y. Fukazawa, R. Shigemoto, and K. Matsui, “Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held,” Journal of Physiology, vol. 591, no. 1. Wiley-Blackwell, pp. 219–239, 2013.","short":"T. Budisantoso, H. Harada, N. Kamasawa, Y. Fukazawa, R. Shigemoto, K. Matsui, Journal of Physiology 591 (2013) 219–239.","mla":"Budisantoso, Timotheus, et al. “Evaluation of Glutamate Concentration Transient in the Synaptic Cleft of the Rat Calyx of Held.” Journal of Physiology, vol. 591, no. 1, Wiley-Blackwell, 2013, pp. 219–39, doi:10.1113/jphysiol.2012.241398.","ista":"Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R, Matsui K. 2013. Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held. Journal of Physiology. 591(1), 219–239.","chicago":"Budisantoso, Timotheus, Harumi Harada, Naomi Kamasawa, Yugo Fukazawa, Ryuichi Shigemoto, and Ko Matsui. “Evaluation of Glutamate Concentration Transient in the Synaptic Cleft of the Rat Calyx of Held.” Journal of Physiology. Wiley-Blackwell, 2013. https://doi.org/10.1113/jphysiol.2012.241398."},"extern":1,"quality_controlled":0,"publisher":"Wiley-Blackwell","month":"01","intvolume":" 591","abstract":[{"text":"Establishing the spatiotemporal concentration profile of neurotransmitter following synaptic vesicular release is essential for our understanding of inter-neuronal communication. Such profile is a determinant of synaptic strength, short-term plasticity and inter-synaptic crosstalk. Synaptically released glutamate has been suggested to reach a few millimolar in concentration and last for <1 ms. The synaptic cleft is often conceived as a single concentration compartment, whereas a huge gradient likely exists. Modelling studies have attempted to describe this gradient, but two key parameters, the number of glutamate in a vesicle (NGlu) and its diffusion coefficient (DGlu) in the extracellular space, remained unresolved. To determine this profile, the rat calyx of Held synapse at postnatal day 12-16 was studied where diffusion of glutamate occurs two-dimensionally and where quantification of AMPA receptor distribution on individual postsynaptic specialization on medial nucleus of the trapezoid body principal cells is possible using SDS-digested freeze-fracture replica labelling. To assess the performance of these receptors as glutamate sensors, a kinetic model of the receptors was constructed from outside-out patch recordings. From here, we simulated synaptic responses and compared them with the EPSC recordings. Combinations of NGlu and DGlu with an optimum of 7000 and 0.3 μm2 ms-1 reproduced the data, suggesting slow diffusion. Further simulations showed that a single vesicle does not saturate the synaptic receptors, and that glutamate spillover does not affect the conductance amplitude at this synapse. Using the estimated profile, we also evaluated how the number of multiple vesicle releases at individual active zones affects the amplitude of postsynaptic signals.","lang":"eng"}],"page":"219 - 239","volume":591,"doi":"10.1113/jphysiol.2012.241398","issue":"1","date_published":"2013-01-01T00:00:00Z","date_created":"2018-12-11T11:59:05Z","year":"2013","publication_status":"published","day":"01","publication":"Journal of Physiology"},{"title":"Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons","publist_id":"4204","author":[{"first_name":"Sam","full_name":"Booker, Sam A","last_name":"Booker"},{"first_name":"Anna","last_name":"Gross","full_name":"Gross, Anna"},{"first_name":"Daniel","full_name":"Althof, Daniel","last_name":"Althof"},{"last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"full_name":"Bettler, Bernhard","last_name":"Bettler","first_name":"Bernhard"},{"last_name":"Frotscher","full_name":"Frotscher, Michael","first_name":"Michael"},{"last_name":"Hearing","full_name":"Hearing, Matthew C","first_name":"Matthew"},{"last_name":"Wickman","full_name":"Wickman, Kevin D","first_name":"Kevin"},{"first_name":"Masahiko","full_name":"Watanabe, Masahiko","last_name":"Watanabe"},{"full_name":"Kulik, Ákos","last_name":"Kulik","first_name":"Ákos"},{"full_name":"Vida, Imre","last_name":"Vida","first_name":"Imre"}],"extern":1,"date_updated":"2021-01-12T06:59:05Z","citation":{"ista":"Booker S, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik Á, Vida I. 2013. Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. Journal of Neuroscience. 33(18), 7961–7974.","chicago":"Booker, Sam, Anna Gross, Daniel Althof, Ryuichi Shigemoto, Bernhard Bettler, Michael Frotscher, Matthew Hearing, et al. “Differential GABAB-Receptor-Mediated Effects in Perisomatic- and Dendrite-Targeting Parvalbumin Interneurons.” Journal of Neuroscience. Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.1186-12.2013.","ama":"Booker S, Gross A, Althof D, et al. Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. Journal of Neuroscience. 2013;33(18):7961-7974. doi:10.1523/JNEUROSCI.1186-12.2013","apa":"Booker, S., Gross, A., Althof, D., Shigemoto, R., Bettler, B., Frotscher, M., … Vida, I. (2013). Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1186-12.2013","ieee":"S. Booker et al., “Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons,” Journal of Neuroscience, vol. 33, no. 18. Society for Neuroscience, pp. 7961–7974, 2013.","short":"S. Booker, A. Gross, D. Althof, R. Shigemoto, B. Bettler, M. Frotscher, M. Hearing, K. Wickman, M. Watanabe, Á. Kulik, I. Vida, Journal of Neuroscience 33 (2013) 7961–7974.","mla":"Booker, Sam, et al. “Differential GABAB-Receptor-Mediated Effects in Perisomatic- and Dendrite-Targeting Parvalbumin Interneurons.” Journal of Neuroscience, vol. 33, no. 18, Society for Neuroscience, 2013, pp. 7961–74, doi:10.1523/JNEUROSCI.1186-12.2013."},"status":"public","type":"journal_article","_id":"2693","date_created":"2018-12-11T11:59:06Z","issue":"18","volume":33,"doi":"10.1523/JNEUROSCI.1186-12.2013","date_published":"2013-05-01T00:00:00Z","page":"7961 - 7974","publication":"Journal of Neuroscience","day":"01","publication_status":"published","year":"2013","intvolume":" 33","month":"05","quality_controlled":0,"publisher":"Society for Neuroscience","abstract":[{"text":"Inhibitory parvalbumin-containing interneurons (PVIs) control neuronal discharge and support the generation of theta- and gammafrequency oscillations in cortical networks. Fast GABAergic input onto PVIs is crucial for their synchronization and oscillatory entrainment, but the role of metabotropic GABAB receptors (GABABRs) in mediating slow presynaptic and postsynaptic inhibition remains unknown. In this study, we have combined high-resolution immunoelectron microscopy, whole-cell patch-clamp recording, and computational modeling to investigate the subcellular distribution and effects of GABABRs and their postsynaptic effector Kir3 channels in rat hippocampal PVIs. Pre-embedding immunogold labeling revealed that the receptors and channels localize at high levels to the extrasynaptic membrane of parvalbumin-immunoreactive dendrites. Immunoreactivity forGABABRs was also present at lower levels on PVI axon terminals. Whole-cell recordings further showed that synaptically released GABA in response to extracellular stimulation evokes large GABABR-mediated slow IPSCs in perisomatic-targeting (PT) PVIs, but only small or no currents in dendrite-targeting (DT) PVIs. In contrast, paired recordings demonstrated that GABABR activation results in presynaptic inhibition at the output synapses of both PT and DT PVIs, but more strongly in the latter. Finally, computational analysis indicated that GABAB IPSCs can phasically modulate the discharge of PT interneurons at theta frequencies. In summary, our results show that GABABRs differentially mediate slow presynaptic and postsynaptic inhibition in PVIs and can contribute to the dynamic modulation of their activity during oscillations. Furthermore, these data provide evidence for a compartment-specific molecular divergence of hippocampal PVI subtypes, suggesting that activation of GABABRs may shift the balance between perisomatic and dendritic inhibition.","lang":"eng"}]}]