[{"article_processing_charge":"No","day":"28","scopus_import":"1","date_published":"2014-12-28T00:00:00Z","article_type":"original","citation":{"chicago":"Cheng, Bingqing, and Michele Ceriotti. “Direct Path Integral Estimators for Isotope Fractionation Ratios.” The Journal of Chemical Physics. AIP Publishing, 2014. https://doi.org/10.1063/1.4904293.","mla":"Cheng, Bingqing, and Michele Ceriotti. “Direct Path Integral Estimators for Isotope Fractionation Ratios.” The Journal of Chemical Physics, vol. 141, no. 24, 244112, AIP Publishing, 2014, doi:10.1063/1.4904293.","short":"B. Cheng, M. Ceriotti, The Journal of Chemical Physics 141 (2014).","ista":"Cheng B, Ceriotti M. 2014. Direct path integral estimators for isotope fractionation ratios. The Journal of Chemical Physics. 141(24), 244112.","apa":"Cheng, B., & Ceriotti, M. (2014). Direct path integral estimators for isotope fractionation ratios. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/1.4904293","ieee":"B. Cheng and M. Ceriotti, “Direct path integral estimators for isotope fractionation ratios,” The Journal of Chemical Physics, vol. 141, no. 24. AIP Publishing, 2014.","ama":"Cheng B, Ceriotti M. Direct path integral estimators for isotope fractionation ratios. The Journal of Chemical Physics. 2014;141(24). doi:10.1063/1.4904293"},"publication":"The Journal of Chemical Physics","issue":"24","abstract":[{"lang":"eng","text":"Fractionation of isotopes among distinct molecules or phases is a quantum effect which is often exploited to obtain insights on reaction mechanisms, biochemical, geochemical, and atmospheric phenomena. Accurate evaluation of isotope ratios in atomistic simulations is challenging, because one needs to perform a thermodynamic integration with respect to the isotope mass, along with time-consuming path integral calculations. By re-formulating the problem as a particle exchange in the ring polymer partition function, we derive new estimators giving direct access to the differential partitioning of isotopes, which can simplify the calculations by avoiding thermodynamic integration. We demonstrate the efficiency of these estimators by applying them to investigate the isotope fractionation ratios in the gas-phase Zundel cation, and in a few simple hydrocarbons."}],"type":"journal_article","oa_version":"Preprint","intvolume":" 141","status":"public","title":"Direct path integral estimators for isotope fractionation ratios","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","_id":"9662","publication_identifier":{"issn":["0021-9606"],"eissn":["1089-7690"]},"month":"12","language":[{"iso":"eng"}],"doi":"10.1063/1.4904293","quality_controlled":"1","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1412.1308","open_access":"1"}],"external_id":{"arxiv":["1412.1308"],"pmid":["25554138"]},"extern":"1","article_number":"244112","volume":141,"date_created":"2021-07-15T09:22:49Z","date_updated":"2021-08-09T12:32:24Z","author":[{"id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","orcid":"0000-0002-3584-9632","first_name":"Bingqing","last_name":"Cheng","full_name":"Cheng, Bingqing"},{"first_name":"Michele","last_name":"Ceriotti","full_name":"Ceriotti, Michele"}],"publisher":"AIP Publishing","publication_status":"published","pmid":1,"year":"2014"},{"month":"05","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/1401.2948","open_access":"1"}],"external_id":{"arxiv":["1401.2948"]},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1103/PhysRevLett.112.216806","article_number":"216806","extern":"1","publist_id":"7957","publication_status":"published","publisher":"American Physical Society","acknowledgement":"Research supported by the Danish National Research Foundation, the Office of Science at the U.S. Department of Energy, the National Science Foundation (PHY-1104528), and the Defense Advanced Research Projects Agency through the QuEST Program.","year":"2014","date_updated":"2021-01-12T08:22:19Z","date_created":"2018-12-11T11:44:36Z","volume":112,"author":[{"full_name":"Higginbotham, Andrew P","first_name":"Andrew P","last_name":"Higginbotham","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2607-2363"},{"last_name":"Kuemmeth","first_name":"Ferdinand","full_name":"Kuemmeth, Ferdinand"},{"full_name":"Larsen, Thorvald","first_name":"Thorvald","last_name":"Larsen"},{"first_name":"Mattias","last_name":"Fitzpatrick","full_name":"Fitzpatrick, Mattias"},{"full_name":"Yao, Jun","first_name":"Jun","last_name":"Yao"},{"full_name":"Yan, Hao","first_name":"Hao","last_name":"Yan"},{"last_name":"Lieber","first_name":"Charles","full_name":"Lieber, Charles"},{"last_name":"Marcus","first_name":"Charles","full_name":"Marcus, Charles"}],"day":"29","publication":"APS Physics, Physical Review Letters","citation":{"mla":"Higginbotham, Andrew P., et al. “Antilocalization of Coulomb Blockade in a Ge/Si Nanowire.” APS Physics, Physical Review Letters, vol. 112, no. 21, 216806, American Physical Society, 2014, doi:10.1103/PhysRevLett.112.216806.","short":"A.P. Higginbotham, F. Kuemmeth, T. Larsen, M. Fitzpatrick, J. Yao, H. Yan, C. Lieber, C. Marcus, APS Physics, Physical Review Letters 112 (2014).","chicago":"Higginbotham, Andrew P, Ferdinand Kuemmeth, Thorvald Larsen, Mattias Fitzpatrick, Jun Yao, Hao Yan, Charles Lieber, and Charles Marcus. “Antilocalization of Coulomb Blockade in a Ge/Si Nanowire.” APS Physics, Physical Review Letters. American Physical Society, 2014. https://doi.org/10.1103/PhysRevLett.112.216806.","ama":"Higginbotham AP, Kuemmeth F, Larsen T, et al. Antilocalization of coulomb blockade in a Ge/Si nanowire. APS Physics, Physical Review Letters. 2014;112(21). doi:10.1103/PhysRevLett.112.216806","ista":"Higginbotham AP, Kuemmeth F, Larsen T, Fitzpatrick M, Yao J, Yan H, Lieber C, Marcus C. 2014. Antilocalization of coulomb blockade in a Ge/Si nanowire. APS Physics, Physical Review Letters. 112(21), 216806.","ieee":"A. P. Higginbotham et al., “Antilocalization of coulomb blockade in a Ge/Si nanowire,” APS Physics, Physical Review Letters, vol. 112, no. 21. American Physical Society, 2014.","apa":"Higginbotham, A. P., Kuemmeth, F., Larsen, T., Fitzpatrick, M., Yao, J., Yan, H., … Marcus, C. (2014). Antilocalization of coulomb blockade in a Ge/Si nanowire. APS Physics, Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.112.216806"},"date_published":"2014-05-29T00:00:00Z","type":"journal_article","abstract":[{"text":"The distribution of Coulomb blockade peak heights as a function of magnetic field is investigated experimentally in a Ge-Si nanowire quantum dot. Strong spin-orbit coupling in this hole-gas system leads to antilocalization of Coulomb blockade peaks, consistent with theory. In particular, the peak height distribution has its maximum away from zero at zero magnetic field, with an average that decreases with increasing field. Magnetoconductance in the open-wire regime places a bound on the spin-orbit length (lso < 20 nm), consistent with values extracted in the Coulomb blockade regime (lso < 25 nm).","lang":"eng"}],"issue":"21","status":"public","title":"Antilocalization of coulomb blockade in a Ge/Si nanowire","intvolume":" 112","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"97","oa_version":"None"},{"issue":"11","abstract":[{"text":"We have assembled a network of cell-fate determining transcription factors that play a key role in the specification of the ventral neuronal subtypes of the spinal cord on the basis of published transcriptional interactions. Asynchronous Boolean modelling of the network was used to compare simulation results with reported experimental observations. Such comparison highlighted the need to include additional regulatory connections in order to obtain the fixed point attractors of the model associated with the five known progenitor cell types located in the ventral spinal cord. The revised gene regulatory network reproduced previously observed cell state switches between progenitor cells observed in knock-out animal models or in experiments where the transcription factors were overexpressed. Furthermore the network predicted the inhibition of Irx3 by Nkx2.2 and this prediction was tested experimentally. Our results provide evidence for the existence of an as yet undescribed inhibitory connection which could potentially have significance beyond the ventral spinal cord. The work presented in this paper demonstrates the strength of Boolean modelling for identifying gene regulatory networks.","lang":"eng"}],"type":"journal_article","oa_version":"Published Version","file":[{"access_level":"open_access","file_name":"IST-2016-435-v1+1_journal.pone.0111430.pdf","creator":"system","content_type":"application/pdf","file_size":829363,"file_id":"4850","relation":"main_file","checksum":"a2289b843f7463eb1233f9ce45e6a943","date_created":"2018-12-12T10:10:58Z","date_updated":"2020-07-14T12:45:24Z"}],"pubrep_id":"435","intvolume":" 9","status":"public","title":"Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord","ddc":["570"],"_id":"2004","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","day":"14","scopus_import":1,"date_published":"2014-11-14T00:00:00Z","citation":{"chicago":"Lovrics, Anna, Yu Gao, Bianka Juhász, István Bock, Helen Byrne, András Dinnyés, and Krisztián Kovács. “Boolean Modelling Reveals New Regulatory Connections between Transcription Factors Orchestrating the Development of the Ventral Spinal Cord.” PLoS One. Public Library of Science, 2014. https://doi.org/10.1371/journal.pone.0111430.","short":"A. Lovrics, Y. Gao, B. Juhász, I. Bock, H. Byrne, A. Dinnyés, K. Kovács, PLoS One 9 (2014).","mla":"Lovrics, Anna, et al. “Boolean Modelling Reveals New Regulatory Connections between Transcription Factors Orchestrating the Development of the Ventral Spinal Cord.” PLoS One, vol. 9, no. 11, e111430, Public Library of Science, 2014, doi:10.1371/journal.pone.0111430.","ieee":"A. Lovrics et al., “Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord,” PLoS One, vol. 9, no. 11. Public Library of Science, 2014.","apa":"Lovrics, A., Gao, Y., Juhász, B., Bock, I., Byrne, H., Dinnyés, A., & Kovács, K. (2014). Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0111430","ista":"Lovrics A, Gao Y, Juhász B, Bock I, Byrne H, Dinnyés A, Kovács K. 2014. Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord. PLoS One. 9(11), e111430.","ama":"Lovrics A, Gao Y, Juhász B, et al. Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord. PLoS One. 2014;9(11). doi:10.1371/journal.pone.0111430"},"publication":"PLoS One","ec_funded":1,"publist_id":"5072","file_date_updated":"2020-07-14T12:45:24Z","article_number":"e111430","volume":9,"date_updated":"2023-02-23T14:06:14Z","date_created":"2018-12-11T11:55:09Z","related_material":{"record":[{"id":"9722","status":"public","relation":"research_data"}]},"author":[{"full_name":"Lovrics, Anna","last_name":"Lovrics","first_name":"Anna"},{"full_name":"Gao, Yu","first_name":"Yu","last_name":"Gao"},{"full_name":"Juhász, Bianka","first_name":"Bianka","last_name":"Juhász"},{"full_name":"Bock, István","first_name":"István","last_name":"Bock"},{"last_name":"Byrne","first_name":"Helen","full_name":"Byrne, Helen"},{"full_name":"Dinnyés, András","last_name":"Dinnyés","first_name":"András"},{"first_name":"Krisztián","last_name":"Kovács","id":"2AB5821E-F248-11E8-B48F-1D18A9856A87","full_name":"Kovács, Krisztián"}],"publisher":"Public Library of Science","department":[{"_id":"JoCs"}],"publication_status":"published","year":"2014","month":"11","language":[{"iso":"eng"}],"doi":"10.1371/journal.pone.0111430","project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"}],"quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"}},{"type":"research_data_reference","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"2004"}]},"author":[{"first_name":"Anna","last_name":"Lovrics","full_name":"Lovrics, Anna"},{"last_name":"Gao","first_name":"Yu","full_name":"Gao, Yu"},{"last_name":"Juhász","first_name":"Bianka","full_name":"Juhász, Bianka"},{"last_name":"Bock","first_name":"István","full_name":"Bock, István"},{"full_name":"Byrne, Helen M.","last_name":"Byrne","first_name":"Helen M."},{"last_name":"Dinnyés","first_name":"András","full_name":"Dinnyés, András"},{"id":"2AB5821E-F248-11E8-B48F-1D18A9856A87","first_name":"Krisztián","last_name":"Kovács","full_name":"Kovács, Krisztián"}],"oa_version":"Published Version","date_updated":"2023-02-23T10:24:07Z","date_created":"2021-07-26T14:35:00Z","_id":"9722","year":"2014","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","department":[{"_id":"JoCs"}],"publisher":"Public Library of Science","title":"Transition probability between TF expression states when Dbx2 inhibits Nkx2.2","status":"public","article_processing_charge":"No","day":"14","month":"11","date_published":"2014-11-14T00:00:00Z","doi":"10.1371/journal.pone.0111430.s006","citation":{"chicago":"Lovrics, Anna, Yu Gao, Bianka Juhász, István Bock, Helen M. Byrne, András Dinnyés, and Krisztián Kovács. “Transition Probability between TF Expression States When Dbx2 Inhibits Nkx2.2.” Public Library of Science, 2014. https://doi.org/10.1371/journal.pone.0111430.s006.","short":"A. Lovrics, Y. Gao, B. Juhász, I. Bock, H.M. Byrne, A. Dinnyés, K. Kovács, (2014).","mla":"Lovrics, Anna, et al. Transition Probability between TF Expression States When Dbx2 Inhibits Nkx2.2. Public Library of Science, 2014, doi:10.1371/journal.pone.0111430.s006.","ieee":"A. Lovrics et al., “Transition probability between TF expression states when Dbx2 inhibits Nkx2.2.” Public Library of Science, 2014.","apa":"Lovrics, A., Gao, Y., Juhász, B., Bock, I., Byrne, H. M., Dinnyés, A., & Kovács, K. (2014). Transition probability between TF expression states when Dbx2 inhibits Nkx2.2. Public Library of Science. https://doi.org/10.1371/journal.pone.0111430.s006","ista":"Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács K. 2014. Transition probability between TF expression states when Dbx2 inhibits Nkx2.2, Public Library of Science, 10.1371/journal.pone.0111430.s006.","ama":"Lovrics A, Gao Y, Juhász B, et al. Transition probability between TF expression states when Dbx2 inhibits Nkx2.2. 2014. doi:10.1371/journal.pone.0111430.s006"}},{"type":"journal_article","issue":"9","abstract":[{"text":"A fundamental question in biology is the following: what is the time scale that is needed for evolutionary innovations? There are many results that characterize single steps in terms of the fixation time of new mutants arising in populations of certain size and structure. But here we ask a different question, which is concerned with the much longer time scale of evolutionary trajectories: how long does it take for a population exploring a fitness landscape to find target sequences that encode new biological functions? Our key variable is the length, (Formula presented.) of the genetic sequence that undergoes adaptation. In computer science there is a crucial distinction between problems that require algorithms which take polynomial or exponential time. The latter are considered to be intractable. Here we develop a theoretical approach that allows us to estimate the time of evolution as function of (Formula presented.) We show that adaptation on many fitness landscapes takes time that is exponential in (Formula presented.) even if there are broad selection gradients and many targets uniformly distributed in sequence space. These negative results lead us to search for specific mechanisms that allow evolution to work on polynomial time scales. We study a regeneration process and show that it enables evolution to work in polynomial time.","lang":"eng"}],"intvolume":" 10","status":"public","title":"The time scale of evolutionary innovation","ddc":["510"],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"2039","oa_version":"Published Version","file":[{"content_type":"application/pdf","file_size":1399093,"creator":"system","access_level":"open_access","file_name":"IST-2016-440-v1+1_journal.pcbi.1003818.pdf","checksum":"712d4c5787ddf97809cfc962507f0738","date_created":"2018-12-12T10:11:35Z","date_updated":"2020-07-14T12:45:26Z","relation":"main_file","file_id":"4890"}],"pubrep_id":"440","scopus_import":1,"has_accepted_license":"1","day":"11","citation":{"chicago":"Chatterjee, Krishnendu, Andreas Pavlogiannis, Ben Adlam, and Martin Nowak. “The Time Scale of Evolutionary Innovation.” PLoS Computational Biology. Public Library of Science, 2014. https://doi.org/10.1371/journal.pcbi.1003818.","short":"K. Chatterjee, A. Pavlogiannis, B. Adlam, M. Nowak, PLoS Computational Biology 10 (2014).","mla":"Chatterjee, Krishnendu, et al. “The Time Scale of Evolutionary Innovation.” PLoS Computational Biology, vol. 10, no. 9, 7p, Public Library of Science, 2014, doi:10.1371/journal.pcbi.1003818.","ieee":"K. Chatterjee, A. Pavlogiannis, B. Adlam, and M. Nowak, “The time scale of evolutionary innovation,” PLoS Computational Biology, vol. 10, no. 9. Public Library of Science, 2014.","apa":"Chatterjee, K., Pavlogiannis, A., Adlam, B., & Nowak, M. (2014). The time scale of evolutionary innovation. PLoS Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1003818","ista":"Chatterjee K, Pavlogiannis A, Adlam B, Nowak M. 2014. The time scale of evolutionary innovation. PLoS Computational Biology. 10(9), 7p.","ama":"Chatterjee K, Pavlogiannis A, Adlam B, Nowak M. The time scale of evolutionary innovation. PLoS Computational Biology. 2014;10(9). doi:10.1371/journal.pcbi.1003818"},"publication":"PLoS Computational Biology","date_published":"2014-09-11T00:00:00Z","article_number":"7p","publist_id":"5012","ec_funded":1,"file_date_updated":"2020-07-14T12:45:26Z","publisher":"Public Library of Science","department":[{"_id":"KrCh"}],"publication_status":"published","year":"2014","volume":10,"date_created":"2018-12-11T11:55:22Z","date_updated":"2023-02-23T14:06:36Z","related_material":{"record":[{"id":"9739","relation":"research_data","status":"public"}]},"author":[{"last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu"},{"full_name":"Pavlogiannis, Andreas","orcid":"0000-0002-8943-0722","id":"49704004-F248-11E8-B48F-1D18A9856A87","last_name":"Pavlogiannis","first_name":"Andreas"},{"last_name":"Adlam","first_name":"Ben","full_name":"Adlam, Ben"},{"full_name":"Nowak, Martin","last_name":"Nowak","first_name":"Martin"}],"month":"09","project":[{"call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"name":"Game Theory","call_identifier":"FWF","grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425"},{"name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","grant_number":"279307"},{"name":"Microsoft Research Faculty Fellowship","_id":"2587B514-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1371/journal.pcbi.1003818"},{"date_published":"2014-07-23T00:00:00Z","article_type":"original","page":"1701 - 1710","publication":"Behavioral Ecology and Sociobiology","citation":{"mla":"Westhus, Claudia, et al. “Increased Grooming after Repeated Brood Care Provides Sanitary Benefits in a Clonal Ant.” Behavioral Ecology and Sociobiology, vol. 68, no. 10, Springer, 2014, pp. 1701–10, doi:10.1007/s00265-014-1778-8.","short":"C. Westhus, L.V. Ugelvig, E. Tourdot, J. Heinze, C. Doums, S. Cremer, Behavioral Ecology and Sociobiology 68 (2014) 1701–1710.","chicago":"Westhus, Claudia, Line V Ugelvig, Edouard Tourdot, Jürgen Heinze, Claudie Doums, and Sylvia Cremer. “Increased Grooming after Repeated Brood Care Provides Sanitary Benefits in a Clonal Ant.” Behavioral Ecology and Sociobiology. Springer, 2014. https://doi.org/10.1007/s00265-014-1778-8.","ama":"Westhus C, Ugelvig LV, Tourdot E, Heinze J, Doums C, Cremer S. Increased grooming after repeated brood care provides sanitary benefits in a clonal ant. Behavioral Ecology and Sociobiology. 2014;68(10):1701-1710. doi:10.1007/s00265-014-1778-8","ista":"Westhus C, Ugelvig LV, Tourdot E, Heinze J, Doums C, Cremer S. 2014. Increased grooming after repeated brood care provides sanitary benefits in a clonal ant. Behavioral Ecology and Sociobiology. 68(10), 1701–1710.","apa":"Westhus, C., Ugelvig, L. V., Tourdot, E., Heinze, J., Doums, C., & Cremer, S. (2014). Increased grooming after repeated brood care provides sanitary benefits in a clonal ant. Behavioral Ecology and Sociobiology. Springer. https://doi.org/10.1007/s00265-014-1778-8","ieee":"C. Westhus, L. V. Ugelvig, E. Tourdot, J. Heinze, C. Doums, and S. Cremer, “Increased grooming after repeated brood care provides sanitary benefits in a clonal ant,” Behavioral Ecology and Sociobiology, vol. 68, no. 10. Springer, pp. 1701–1710, 2014."},"day":"23","article_processing_charge":"No","scopus_import":"1","oa_version":"None","status":"public","title":"Increased grooming after repeated brood care provides sanitary benefits in a clonal ant","intvolume":" 68","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"2161","abstract":[{"lang":"eng","text":"Repeated pathogen exposure is a common threat in colonies of social insects, posing selection pressures on colony members to respond with improved disease-defense performance. We here tested whether experience gained by repeated tending of low-level fungus-exposed (Metarhizium robertsii) larvae may alter the performance of sanitary brood care in the clonal ant, Platythyrea punctata. We trained ants individually over nine consecutive trials to either sham-treated or fungus-exposed larvae. We then compared the larval grooming behavior of naive and trained ants and measured how effectively they removed infectious fungal conidiospores from the fungus-exposed larvae. We found that the ants changed the duration of larval grooming in response to both, larval treatment and their level of experience: (1) sham-treated larvae received longer grooming than the fungus-exposed larvae and (2) trained ants performed less self-grooming but longer larval grooming than naive ants, which was true for both, ants trained to fungus-exposed and also to sham-treated larvae. Ants that groomed the fungus-exposed larvae for longer periods removed a higher number of fungal conidiospores from the surface of the fungus-exposed larvae. As experienced ants performed longer larval grooming, they were more effective in fungal removal, thus making them better caretakers under pathogen attack of the colony. By studying this clonal ant, we can thus conclude that even in the absence of genetic variation between colony members, differences in experience levels of brood care may affect performance of sanitary brood care in social insects."}],"issue":"10","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1007/s00265-014-1778-8","quality_controlled":"1","project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"},{"name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects","call_identifier":"FP7","_id":"25DC711C-B435-11E9-9278-68D0E5697425","grant_number":"243071"},{"name":"Host-Parasite Coevolution","grant_number":"CR-118/3-1","_id":"25DAF0B2-B435-11E9-9278-68D0E5697425"}],"month":"07","publication_identifier":{"issn":["0340-5443"]},"date_created":"2018-12-11T11:56:03Z","date_updated":"2023-02-23T14:06:46Z","volume":68,"author":[{"last_name":"Westhus","first_name":"Claudia","id":"ca9c6ca9-e8aa-11ec-a586-b9471ede0494","full_name":"Westhus, Claudia"},{"orcid":"0000-0003-1832-8883","id":"3DC97C8E-F248-11E8-B48F-1D18A9856A87","last_name":"Ugelvig","first_name":"Line V","full_name":"Ugelvig, Line V"},{"last_name":"Tourdot","first_name":"Edouard","full_name":"Tourdot, Edouard"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"},{"full_name":"Doums, Claudie","first_name":"Claudie","last_name":"Doums"},{"first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia"}],"related_material":{"record":[{"relation":"research_data","status":"public","id":"9742"}]},"publication_status":"published","department":[{"_id":"SyCr"}],"publisher":"Springer","acknowledgement":"We thank Katrin Kellner for colony establishment and characterization, Mike Bidochka for the fungal strain, Meghan Vyleta for fungal strain characterization, Martina Klatt and Simon Tragust for help in the laboratory, Dimitri Missoh for developing the software BioLogic, and Mark Brown and Raphaël Jeanson for discussion and help with data analysis. The study was funded by the European Research Council (ERC Starting Grant to SC; Marie Curie IEF to LVU) and the German Research Foundation DFG (to SC and to JH), and CW received funding by the doctoral school Diversité du Vivant (Cotutelle project to CD and SC).\r\n","year":"2014","publist_id":"4823","ec_funded":1},{"month":"09","language":[{"iso":"eng"}],"doi":"10.1098/rspb.2014.1679","quality_controlled":"1","oa":1,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211454/","open_access":"1"}],"publist_id":"5019","article_number":"20141679","date_created":"2018-12-11T11:55:21Z","date_updated":"2023-02-23T14:06:44Z","volume":281,"author":[{"last_name":"Lagator","first_name":"Mato","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","full_name":"Lagator, Mato"},{"last_name":"Colegrave","first_name":"Nick","full_name":"Colegrave, Nick"},{"full_name":"Neve, Paul","last_name":"Neve","first_name":"Paul"}],"related_material":{"record":[{"status":"public","relation":"research_data","id":"9741"}]},"publication_status":"published","publisher":"Royal Society, The","department":[{"_id":"CaGu"}],"year":"2014","acknowledgement":"The project was supported by Leverhulme Trust.","day":"17","scopus_import":1,"date_published":"2014-09-17T00:00:00Z","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","citation":{"chicago":"Lagator, Mato, Nick Colegrave, and Paul Neve. “Selection History and Epistatic Interactions Impact Dynamics of Adaptation to Novel Environmental Stresses.” Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The, 2014. https://doi.org/10.1098/rspb.2014.1679.","short":"M. Lagator, N. Colegrave, P. Neve, Proceedings of the Royal Society of London Series B Biological Sciences 281 (2014).","mla":"Lagator, Mato, et al. “Selection History and Epistatic Interactions Impact Dynamics of Adaptation to Novel Environmental Stresses.” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 281, no. 1794, 20141679, Royal Society, The, 2014, doi:10.1098/rspb.2014.1679.","apa":"Lagator, M., Colegrave, N., & Neve, P. (2014). Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The. https://doi.org/10.1098/rspb.2014.1679","ieee":"M. Lagator, N. Colegrave, and P. Neve, “Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 281, no. 1794. Royal Society, The, 2014.","ista":"Lagator M, Colegrave N, Neve P. 2014. Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Proceedings of the Royal Society of London Series B Biological Sciences. 281(1794), 20141679.","ama":"Lagator M, Colegrave N, Neve P. Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Proceedings of the Royal Society of London Series B Biological Sciences. 2014;281(1794). doi:10.1098/rspb.2014.1679"},"abstract":[{"text":" In rapidly changing environments, selection history may impact the dynamics of adaptation. Mutations selected in one environment may result in pleiotropic fitness trade-offs in subsequent novel environments, slowing the rates of adaptation. Epistatic interactions between mutations selected in sequential stressful environments may slow or accelerate subsequent rates of adaptation, depending on the nature of that interaction. We explored the dynamics of adaptation during sequential exposure to herbicides with different modes of action in Chlamydomonas reinhardtii. Evolution of resistance to two of the herbicides was largely independent of selection history. For carbetamide, previous adaptation to other herbicide modes of action positively impacted the likelihood of adaptation to this herbicide. Furthermore, while adaptation to all individual herbicides was associated with pleiotropic fitness costs in stress-free environments, we observed that accumulation of resistance mechanisms was accompanied by a reduction in overall fitness costs. We suggest that antagonistic epistasis may be a driving mechanism that enables populations to more readily adapt in novel environments. These findings highlight the potential for sequences of xenobiotics to facilitate the rapid evolution of multiple-drug and -pesticide resistance, as well as the potential for epistatic interactions between adaptive mutations to facilitate evolutionary rescue in rapidly changing environments. ","lang":"eng"}],"issue":"1794","type":"journal_article","oa_version":"Submitted Version","status":"public","title":"Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses","intvolume":" 281","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"2036"},{"_id":"9740","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2014","publisher":"Dryad","department":[{"_id":"SyCr"}],"status":"public","title":"Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host","related_material":{"record":[{"id":"1993","status":"public","relation":"used_in_publication"}]},"author":[{"full_name":"Konrad, Matthias","last_name":"Konrad","first_name":"Matthias","id":"46528076-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Grasse","first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V"},{"full_name":"Tragust, Simon","first_name":"Simon","last_name":"Tragust","id":"35A7A418-F248-11E8-B48F-1D18A9856A87"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia"}],"oa_version":"Published Version","date_updated":"2023-02-23T10:23:32Z","date_created":"2021-07-28T08:38:40Z","type":"research_data_reference","abstract":[{"text":"The fitness effects of symbionts on their hosts can be context-dependent, with usually benign symbionts causing detrimental effects when their hosts are stressed, or typically parasitic symbionts providing protection towards their hosts (e.g. against pathogen infection). Here, we studied the novel association between the invasive garden ant Lasius neglectus and its fungal ectosymbiont Laboulbenia formicarum for potential costs and benefits. We tested ants with different Laboulbenia levels for their survival and immunity under resource limitation and exposure to the obligate killing entomopathogen Metarhizium brunneum. While survival of L. neglectus workers under starvation was significantly decreased with increasing Laboulbenia levels, host survival under Metarhizium exposure increased with higher levels of the ectosymbiont, suggesting a symbiont-mediated anti-pathogen protection, which seems to be driven mechanistically by both improved sanitary behaviours and an upregulated immune system. Ants with high Laboulbenia levels showed significantly longer self-grooming and elevated expression of immune genes relevant for wound repair and antifungal responses (β-1,3-glucan binding protein, Prophenoloxidase), compared with ants carrying low Laboulbenia levels. This suggests that the ectosymbiont Laboulbenia formicarum weakens its ant host by either direct resource exploitation or the costs of an upregulated behavioural and immunological response, which, however, provides a prophylactic protection upon later exposure to pathogens.","lang":"eng"}],"oa":1,"citation":{"chicago":"Konrad, Matthias, Anna V Grasse, Simon Tragust, and Sylvia Cremer. “Data from: Anti-Pathogen Protection versus Survival Costs Mediated by an Ectosymbiont in an Ant Host.” Dryad, 2014. https://doi.org/10.5061/dryad.vm0vc.","short":"M. Konrad, A.V. Grasse, S. Tragust, S. Cremer, (2014).","mla":"Konrad, Matthias, et al. Data from: Anti-Pathogen Protection versus Survival Costs Mediated by an Ectosymbiont in an Ant Host. Dryad, 2014, doi:10.5061/dryad.vm0vc.","apa":"Konrad, M., Grasse, A. V., Tragust, S., & Cremer, S. (2014). Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host. Dryad. https://doi.org/10.5061/dryad.vm0vc","ieee":"M. Konrad, A. V. Grasse, S. Tragust, and S. Cremer, “Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host.” Dryad, 2014.","ista":"Konrad M, Grasse AV, Tragust S, Cremer S. 2014. Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host, Dryad, 10.5061/dryad.vm0vc.","ama":"Konrad M, Grasse AV, Tragust S, Cremer S. Data from: Anti-pathogen protection versus survival costs mediated by an ectosymbiont in an ant host. 2014. doi:10.5061/dryad.vm0vc"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.vm0vc"}],"date_published":"2014-11-13T00:00:00Z","doi":"10.5061/dryad.vm0vc","article_processing_charge":"No","day":"13","month":"11"},{"author":[{"id":"345D25EC-F248-11E8-B48F-1D18A9856A87","last_name":"Lagator","first_name":"Mato","full_name":"Lagator, Mato"},{"first_name":"Nick","last_name":"Colegrave","full_name":"Colegrave, Nick"},{"full_name":"Neve, Paul","first_name":"Paul","last_name":"Neve"}],"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"2036"}]},"date_updated":"2023-02-23T10:25:31Z","date_created":"2021-07-28T08:48:06Z","oa_version":"Published Version","_id":"9741","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2014","title":"Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses","status":"public","department":[{"_id":"CaGu"}],"publisher":"Dryad","abstract":[{"text":"In rapidly changing environments, selection history may impact the dynamics of adaptation. Mutations selected in one environment may result in pleiotropic fitness trade-offs in subsequent novel environments, slowing the rates of adaptation. Epistatic interactions between mutations selected in sequential stressful environments may slow or accelerate subsequent rates of adaptation, depending on the nature of that interaction. We explored the dynamics of adaptation during sequential exposure to herbicides with different modes of action in Chlamydomonas reinhardtii. Evolution of resistance to two of the herbicides was largely independent of selection history. For carbetamide, previous adaptation to other herbicide modes of action positively impacted the likelihood of adaptation to this herbicide. Furthermore, while adaptation to all individual herbicides was associated with pleiotropic fitness costs in stress-free environments, we observed that accumulation of resistance mechanisms was accompanied by a reduction in overall fitness costs. We suggest that antagonistic epistasis may be a driving mechanism that enables populations to more readily adapt in novel environments. These findings highlight the potential for sequences of xenobiotics to facilitate the rapid evolution of multiple-drug and -pesticide resistance, as well as the potential for epistatic interactions between adaptive mutations to facilitate evolutionary rescue in rapidly changing environments.","lang":"eng"}],"type":"research_data_reference","date_published":"2014-08-21T00:00:00Z","doi":"10.5061/dryad.85dn7","citation":{"ieee":"M. Lagator, N. Colegrave, and P. Neve, “Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses.” Dryad, 2014.","apa":"Lagator, M., Colegrave, N., & Neve, P. (2014). Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Dryad. https://doi.org/10.5061/dryad.85dn7","ista":"Lagator M, Colegrave N, Neve P. 2014. Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses, Dryad, 10.5061/dryad.85dn7.","ama":"Lagator M, Colegrave N, Neve P. Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. 2014. doi:10.5061/dryad.85dn7","chicago":"Lagator, Mato, Nick Colegrave, and Paul Neve. “Data from: Selection History and Epistatic Interactions Impact Dynamics of Adaptation to Novel Environmental Stresses.” Dryad, 2014. https://doi.org/10.5061/dryad.85dn7.","short":"M. Lagator, N. Colegrave, P. Neve, (2014).","mla":"Lagator, Mato, et al. Data from: Selection History and Epistatic Interactions Impact Dynamics of Adaptation to Novel Environmental Stresses. Dryad, 2014, doi:10.5061/dryad.85dn7."},"main_file_link":[{"url":"https://doi.org/10.5061/dryad.85dn7","open_access":"1"}],"oa":1,"month":"08","day":"21","article_processing_charge":"No"},{"article_processing_charge":"No","month":"09","day":"11","citation":{"mla":"Chatterjee, Krishnendu, et al. Detailed Proofs for “The Time Scale of Evolutionary Innovation.” Public Library of Science, 2014, doi:10.1371/journal.pcbi.1003818.s001.","short":"K. Chatterjee, A. Pavlogiannis, B. Adlam, M. Novak, (2014).","chicago":"Chatterjee, Krishnendu, Andreas Pavlogiannis, Ben Adlam, and Martin Novak. “Detailed Proofs for ‘The Time Scale of Evolutionary Innovation.’” Public Library of Science, 2014. https://doi.org/10.1371/journal.pcbi.1003818.s001.","ama":"Chatterjee K, Pavlogiannis A, Adlam B, Novak M. Detailed proofs for “The time scale of evolutionary innovation.” 2014. doi:10.1371/journal.pcbi.1003818.s001","ista":"Chatterjee K, Pavlogiannis A, Adlam B, Novak M. 2014. Detailed proofs for “The time scale of evolutionary innovation”, Public Library of Science, 10.1371/journal.pcbi.1003818.s001.","ieee":"K. Chatterjee, A. Pavlogiannis, B. Adlam, and M. Novak, “Detailed proofs for ‘The time scale of evolutionary innovation.’” Public Library of Science, 2014.","apa":"Chatterjee, K., Pavlogiannis, A., Adlam, B., & Novak, M. (2014). Detailed proofs for “The time scale of evolutionary innovation.” Public Library of Science. https://doi.org/10.1371/journal.pcbi.1003818.s001"},"date_published":"2014-09-11T00:00:00Z","doi":"10.1371/journal.pcbi.1003818.s001","type":"research_data_reference","publisher":"Public Library of Science","department":[{"_id":"KrCh"}],"status":"public","title":"Detailed proofs for “The time scale of evolutionary innovation”","year":"2014","_id":"9739","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","oa_version":"Published Version","date_updated":"2023-02-23T10:25:37Z","date_created":"2021-07-28T08:13:57Z","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"2039"}]},"author":[{"orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu"},{"full_name":"Pavlogiannis, Andreas","first_name":"Andreas","last_name":"Pavlogiannis","id":"49704004-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8943-0722"},{"full_name":"Adlam, Ben","first_name":"Ben","last_name":"Adlam"},{"full_name":"Novak, Martin","last_name":"Novak","first_name":"Martin"}]}]