[{"quality_controlled":"1","publisher":"Springer Nature","oa":1,"has_accepted_license":"1","isi":1,"year":"2020","day":"19","publication":"Nature Communications","doi":"10.1038/s41467-020-16932-z","date_published":"2020-06-19T00:00:00Z","date_created":"2020-06-29T07:59:35Z","article_number":"3105","project":[{"grant_number":"P27201-B22","name":"Revealing the mechanisms underlying drug interactions","call_identifier":"FWF","_id":"25E9AF9E-B435-11E9-9278-68D0E5697425"},{"_id":"25EB3A80-B435-11E9-9278-68D0E5697425","grant_number":"RGP0042/2013","name":"Revealing the fundamental limits of cell growth"}],"citation":{"mla":"Lukacisinova, Marta, et al. “Highly Parallel Lab Evolution Reveals That Epistasis Can Curb the Evolution of Antibiotic Resistance.” Nature Communications, vol. 11, 3105, Springer Nature, 2020, doi:10.1038/s41467-020-16932-z.","ama":"Lukacisinova M, Fernando B, Bollenbach MT. Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance. Nature Communications. 2020;11. doi:10.1038/s41467-020-16932-z","apa":"Lukacisinova, M., Fernando, B., & Bollenbach, M. T. (2020). Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-020-16932-z","short":"M. Lukacisinova, B. Fernando, M.T. Bollenbach, Nature Communications 11 (2020).","ieee":"M. Lukacisinova, B. Fernando, and M. T. Bollenbach, “Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance,” Nature Communications, vol. 11. Springer Nature, 2020.","chicago":"Lukacisinova, Marta, Booshini Fernando, and Mark Tobias Bollenbach. “Highly Parallel Lab Evolution Reveals That Epistasis Can Curb the Evolution of Antibiotic Resistance.” Nature Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-16932-z.","ista":"Lukacisinova M, Fernando B, Bollenbach MT. 2020. Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance. Nature Communications. 11, 3105."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"last_name":"Lukacisinova","orcid":"0000-0002-2519-8004","full_name":"Lukacisinova, Marta","id":"4342E402-F248-11E8-B48F-1D18A9856A87","first_name":"Marta"},{"last_name":"Fernando","full_name":"Fernando, Booshini","first_name":"Booshini"},{"first_name":"Mark Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X","last_name":"Bollenbach"}],"article_processing_charge":"No","external_id":{"isi":["000545685100002"],"pmid":["32561723"]},"title":"Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance","abstract":[{"text":"Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug? Here, we show that strong epistasis between resistance mutations and systematically identified genes can be exploited to control spontaneous resistance evolution. We evolved hundreds of Escherichia coli K-12 mutant populations in parallel, using a robotic platform that tightly controls population size and selection pressure. We find a global diminishing-returns epistasis pattern: strains that are initially more sensitive generally undergo larger resistance gains. However, some gene deletion strains deviate from this general trend and curtail the evolvability of resistance, including deletions of genes for membrane transport, LPS biosynthesis, and chaperones. Deletions of efflux pump genes force evolution on inferior mutational paths, not explored in the wild type, and some of these essentially block resistance evolution. This effect is due to strong negative epistasis with resistance mutations. The identified genes and cellular functions provide potential targets for development of adjuvants that may block spontaneous resistance evolution when combined with antibiotics.","lang":"eng"}],"pmid":1,"oa_version":"Published Version","scopus_import":"1","month":"06","intvolume":" 11","publication_identifier":{"eissn":["20411723"]},"publication_status":"published","file":[{"date_created":"2020-06-30T09:58:50Z","file_name":"2020_NatureComm_Lukacisinova.pdf","creator":"cziletti","date_updated":"2020-07-14T12:48:08Z","file_size":1546491,"file_id":"8071","checksum":"4f5f49d63add331d5eb8a2bae477b396","access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"volume":11,"license":"https://creativecommons.org/licenses/by/4.0/","_id":"8037","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","date_updated":"2023-08-22T07:48:30Z","extern":"1","ddc":["570"],"file_date_updated":"2020-07-14T12:48:08Z"},{"title":"Charge transfer and chemo-mechanical coupling in respiratory complex I","author":[{"full_name":"Gupta, Chitrak","last_name":"Gupta","first_name":"Chitrak"},{"last_name":"Khaniya","full_name":"Khaniya, Umesh","first_name":"Umesh"},{"first_name":"Chun Kit","full_name":"Chan, Chun Kit","last_name":"Chan"},{"full_name":"Dehez, Francois","last_name":"Dehez","first_name":"Francois"},{"last_name":"Shekhar","full_name":"Shekhar, Mrinal","first_name":"Mrinal"},{"last_name":"Gunner","full_name":"Gunner, M. R.","first_name":"M. R."},{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A"},{"first_name":"Christophe","last_name":"Chipot","full_name":"Chipot, Christophe"},{"first_name":"Abhishek","full_name":"Singharoy, Abhishek","last_name":"Singharoy"}],"article_processing_charge":"No","external_id":{"pmid":["32347721"],"isi":["000537415600020"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Gupta, Chitrak, Umesh Khaniya, Chun Kit Chan, Francois Dehez, Mrinal Shekhar, M. R. Gunner, Leonid A Sazanov, Christophe Chipot, and Abhishek Singharoy. “Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.9b13450.","ista":"Gupta C, Khaniya U, Chan CK, Dehez F, Shekhar M, Gunner MR, Sazanov LA, Chipot C, Singharoy A. 2020. Charge transfer and chemo-mechanical coupling in respiratory complex I. Journal of the American Chemical Society. 142(20), 9220–9230.","mla":"Gupta, Chitrak, et al. “Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I.” Journal of the American Chemical Society, vol. 142, no. 20, American Chemical Society, 2020, pp. 9220–30, doi:10.1021/jacs.9b13450.","ama":"Gupta C, Khaniya U, Chan CK, et al. Charge transfer and chemo-mechanical coupling in respiratory complex I. Journal of the American Chemical Society. 2020;142(20):9220-9230. doi:10.1021/jacs.9b13450","apa":"Gupta, C., Khaniya, U., Chan, C. K., Dehez, F., Shekhar, M., Gunner, M. R., … Singharoy, A. (2020). Charge transfer and chemo-mechanical coupling in respiratory complex I. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.9b13450","short":"C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, Journal of the American Chemical Society 142 (2020) 9220–9230.","ieee":"C. Gupta et al., “Charge transfer and chemo-mechanical coupling in respiratory complex I,” Journal of the American Chemical Society, vol. 142, no. 20. American Chemical Society, pp. 9220–9230, 2020."},"doi":"10.1021/jacs.9b13450","date_published":"2020-05-20T00:00:00Z","date_created":"2020-06-29T07:59:35Z","page":"9220-9230","day":"20","publication":"Journal of the American Chemical Society","isi":1,"year":"2020","publisher":"American Chemical Society","quality_controlled":"1","department":[{"_id":"LeSa"}],"date_updated":"2023-08-22T07:49:38Z","status":"public","article_type":"original","type":"journal_article","_id":"8040","volume":142,"issue":"20","related_material":{"record":[{"relation":"research_data","id":"9326","status":"public"},{"relation":"research_data","status":"public","id":"9713"},{"relation":"research_data","status":"public","id":"9878"}]},"language":[{"iso":"eng"}],"publication_identifier":{"issn":["00027863"],"eissn":["15205126"]},"publication_status":"published","month":"05","intvolume":" 142","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"text":"The mitochondrial respiratory chain, formed by five protein complexes, utilizes energy from catabolic processes to synthesize ATP. Complex I, the first and the largest protein complex of the chain, harvests electrons from NADH to reduce quinone, while pumping protons across the mitochondrial membrane. Detailed knowledge of the working principle of such coupled charge-transfer processes remains, however, fragmentary due to bottlenecks in understanding redox-driven conformational transitions and their interplay with the hydrated proton pathways. Complex I from Thermus thermophilus encases 16 subunits with nine iron–sulfur clusters, reduced by electrons from NADH. Here, employing the latest crystal structure of T. thermophilus complex I, we have used microsecond-scale molecular dynamics simulations to study the chemo-mechanical coupling between redox changes of the iron–sulfur clusters and conformational transitions across complex I. First, we identify the redox switches within complex I, which allosterically couple the dynamics of the quinone binding pocket to the site of NADH reduction. Second, our free-energy calculations reveal that the affinity of the quinone, specifically menaquinone, for the binding-site is higher than that of its reduced, menaquinol form—a design essential for menaquinol release. Remarkably, the barriers to diffusive menaquinone dynamics are lesser than that of the more ubiquitous ubiquinone, and the naphthoquinone headgroup of the former furnishes stronger binding interactions with the pocket, favoring menaquinone for charge transport in T. thermophilus. Our computations are consistent with experimentally validated mutations and hierarchize the key residues into three functional classes, identifying new mutation targets. Third, long-range hydrogen-bond networks connecting the quinone-binding site to the transmembrane subunits are found to be responsible for proton pumping. Put together, the simulations reveal the molecular design principles linking redox reactions to quinone turnover to proton translocation in complex I.","lang":"eng"}]},{"intvolume":" 3","month":"06","scopus_import":"1","oa_version":"Published Version","abstract":[{"lang":"eng","text":"When tiny soft ferromagnetic particles are placed along a liquid interface and exposed to a vertical magnetic field, the balance between capillary attraction and magnetic repulsion leads to self-organization into well-defined patterns. Here, we demonstrate experimentally that precessing magnetic fields induce metachronal waves on the periphery of these assemblies, similar to the ones observed in ciliates and some arthropods. The outermost layer of particles behaves like an array of cilia or legs whose sequential movement causes a net and controllable locomotion. This bioinspired many-particle swimming strategy is effective even at low Reynolds number, using only spatially uniform fields to generate the waves."}],"ec_funded":1,"volume":3,"language":[{"iso":"eng"}],"file":[{"checksum":"ed984f7a393f19140b5279a54a3336ad","file_id":"8045","access_level":"open_access","relation":"main_file","content_type":"application/pdf","date_created":"2020-06-29T13:21:24Z","file_name":"2020_CommunicationsPhysics_Collard.pdf","creator":"cziletti","date_updated":"2020-07-14T12:48:08Z","file_size":1907821}],"publication_status":"published","publication_identifier":{"eissn":["23993650"]},"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","article_type":"original","_id":"8036","file_date_updated":"2020-07-14T12:48:08Z","department":[{"_id":"ScWa"}],"ddc":["530"],"date_updated":"2023-08-22T07:47:30Z","oa":1,"quality_controlled":"1","publisher":"Springer Nature","date_created":"2020-06-29T07:59:35Z","date_published":"2020-06-19T00:00:00Z","doi":"10.1038/s42005-020-0380-9","publication":"Communications Physics","day":"19","year":"2020","isi":1,"has_accepted_license":"1","project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"article_number":"112","title":"Magnetically powered metachronal waves induce locomotion in self-assemblies","external_id":{"isi":["000543328000002"]},"article_processing_charge":"No","author":[{"last_name":"Collard","full_name":"Collard, Ylona","first_name":"Ylona"},{"full_name":"Grosjean, Galien M","orcid":"0000-0001-5154-417X","last_name":"Grosjean","first_name":"Galien M","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425"},{"first_name":"Nicolas","last_name":"Vandewalle","full_name":"Vandewalle, Nicolas"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Collard, Ylona, et al. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” Communications Physics, vol. 3, 112, Springer Nature, 2020, doi:10.1038/s42005-020-0380-9.","ieee":"Y. Collard, G. M. Grosjean, and N. Vandewalle, “Magnetically powered metachronal waves induce locomotion in self-assemblies,” Communications Physics, vol. 3. Springer Nature, 2020.","short":"Y. Collard, G.M. Grosjean, N. Vandewalle, Communications Physics 3 (2020).","ama":"Collard Y, Grosjean GM, Vandewalle N. Magnetically powered metachronal waves induce locomotion in self-assemblies. Communications Physics. 2020;3. doi:10.1038/s42005-020-0380-9","apa":"Collard, Y., Grosjean, G. M., & Vandewalle, N. (2020). Magnetically powered metachronal waves induce locomotion in self-assemblies. Communications Physics. Springer Nature. https://doi.org/10.1038/s42005-020-0380-9","chicago":"Collard, Ylona, Galien M Grosjean, and Nicolas Vandewalle. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” Communications Physics. Springer Nature, 2020. https://doi.org/10.1038/s42005-020-0380-9.","ista":"Collard Y, Grosjean GM, Vandewalle N. 2020. Magnetically powered metachronal waves induce locomotion in self-assemblies. Communications Physics. 3, 112."}},{"article_number":"A7","title":"Oblique stripe solutions of channel flow","author":[{"id":"3D85B7C4-F248-11E8-B48F-1D18A9856A87","first_name":"Chaitanya S","last_name":"Paranjape","full_name":"Paranjape, Chaitanya S"},{"full_name":"Duguet, Yohann","last_name":"Duguet","first_name":"Yohann"},{"last_name":"Hof","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"isi":["000539132300001"]},"article_processing_charge":"Yes (via OA deal)","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ista":"Paranjape CS, Duguet Y, Hof B. 2020. Oblique stripe solutions of channel flow. Journal of Fluid Mechanics. 897, A7.","chicago":"Paranjape, Chaitanya S, Yohann Duguet, and Björn Hof. “Oblique Stripe Solutions of Channel Flow.” Journal of Fluid Mechanics. Cambridge University Press, 2020. https://doi.org/10.1017/jfm.2020.322.","short":"C.S. Paranjape, Y. Duguet, B. Hof, Journal of Fluid Mechanics 897 (2020).","ieee":"C. S. Paranjape, Y. Duguet, and B. Hof, “Oblique stripe solutions of channel flow,” Journal of Fluid Mechanics, vol. 897. Cambridge University Press, 2020.","apa":"Paranjape, C. S., Duguet, Y., & Hof, B. (2020). Oblique stripe solutions of channel flow. Journal of Fluid Mechanics. Cambridge University Press. https://doi.org/10.1017/jfm.2020.322","ama":"Paranjape CS, Duguet Y, Hof B. Oblique stripe solutions of channel flow. Journal of Fluid Mechanics. 2020;897. doi:10.1017/jfm.2020.322","mla":"Paranjape, Chaitanya S., et al. “Oblique Stripe Solutions of Channel Flow.” Journal of Fluid Mechanics, vol. 897, A7, Cambridge University Press, 2020, doi:10.1017/jfm.2020.322."},"publisher":"Cambridge University Press","quality_controlled":"1","oa":1,"acknowledgement":"The authors thank S. Zammert and B. Budanur for useful discussions. J. F. Gibson is gratefully acknowledged for the development and the maintenance of the code Channelflow. Y.D. would like to thank P. Schlatter and D. S. Henningson for an early collaboration on a similar topic in the case of plane Couette flow during the years 2008–2013.","date_published":"2020-08-25T00:00:00Z","doi":"10.1017/jfm.2020.322","date_created":"2020-06-29T07:59:35Z","day":"25","publication":"Journal of Fluid Mechanics","has_accepted_license":"1","isi":1,"year":"2020","status":"public","article_type":"original","type":"journal_article","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"_id":"8043","file_date_updated":"2020-07-14T12:48:08Z","department":[{"_id":"BjHo"}],"ddc":["530"],"date_updated":"2023-08-22T07:48:02Z","month":"08","intvolume":" 897","scopus_import":"1","oa_version":"Published Version","abstract":[{"lang":"eng","text":"With decreasing Reynolds number, Re, turbulence in channel flow becomes spatio-temporally intermittent and self-organises into solitary stripes oblique to the mean flow direction. We report here the existence of localised nonlinear travelling wave solutions of the Navier–Stokes equations possessing this obliqueness property. Such solutions are identified numerically using edge tracking coupled with arclength continuation. All solutions emerge in saddle-node bifurcations at values of Re lower than the non-localised solutions. Relative periodic orbit solutions bifurcating from branches of travelling waves have also been computed. A complete parametric study is performed, including their stability, the investigation of their large-scale flow, and the robustness to changes of the numerical domain."}],"volume":897,"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","file":[{"creator":"cziletti","file_size":767873,"date_updated":"2020-07-14T12:48:08Z","file_name":"2020_JournalOfFluidMech_Paranjape.pdf","date_created":"2020-06-30T08:37:37Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_id":"8070","checksum":"3f487bf6d9286787096306eaa18702e8"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["14697645"],"issn":["00221120"]},"publication_status":"published"},{"citation":{"chicago":"Gupta, Chitrak, Umesh Khaniya, Chun Chan, Francois Dehez, Mrinal Shekhar, M. R. Gunner, Leonid A Sazanov, Christophe Chipot, and Abhishek Singharoy. “Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I.” American Chemical Society, 2020. https://doi.org/10.1021/jacs.9b13450.s002.","ista":"Gupta C, Khaniya U, Chan C, Dehez F, Shekhar M, Gunner MR, Sazanov LA, Chipot C, Singharoy A. 2020. Charge transfer and chemo-mechanical coupling in respiratory complex I, American Chemical Society, 10.1021/jacs.9b13450.s002.","mla":"Gupta, Chitrak, et al. Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I. American Chemical Society, 2020, doi:10.1021/jacs.9b13450.s002.","short":"C. Gupta, U. Khaniya, C. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).","ieee":"C. Gupta et al., “Charge transfer and chemo-mechanical coupling in respiratory complex I.” American Chemical Society, 2020.","ama":"Gupta C, Khaniya U, Chan C, et al. Charge transfer and chemo-mechanical coupling in respiratory complex I. 2020. doi:10.1021/jacs.9b13450.s002","apa":"Gupta, C., Khaniya, U., Chan, C., Dehez, F., Shekhar, M., Gunner, M. R., … Singharoy, A. (2020). Charge transfer and chemo-mechanical coupling in respiratory complex I. American Chemical Society. https://doi.org/10.1021/jacs.9b13450.s002"},"date_updated":"2023-08-22T07:49:37Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Gupta, Chitrak","last_name":"Gupta","first_name":"Chitrak"},{"first_name":"Umesh","last_name":"Khaniya","full_name":"Khaniya, Umesh"},{"last_name":"Chan","full_name":"Chan, Chun","first_name":"Chun"},{"first_name":"Francois","last_name":"Dehez","full_name":"Dehez, Francois"},{"first_name":"Mrinal","full_name":"Shekhar, Mrinal","last_name":"Shekhar"},{"first_name":"M. R.","last_name":"Gunner","full_name":"Gunner, M. R."},{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A"},{"last_name":"Chipot","full_name":"Chipot, Christophe","first_name":"Christophe"},{"first_name":"Abhishek","last_name":"Singharoy","full_name":"Singharoy, Abhishek"}],"article_processing_charge":"No","department":[{"_id":"LeSa"}],"title":"Charge transfer and chemo-mechanical coupling in respiratory complex I","_id":"9326","type":"research_data_reference","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"status":"public","year":"2020","day":"20","doi":"10.1021/jacs.9b13450.s002","date_published":"2020-05-20T00:00:00Z","related_material":{"record":[{"relation":"used_in_publication","id":"8040","status":"public"}]},"license":"https://creativecommons.org/licenses/by-nc/4.0/","date_created":"2021-04-14T12:05:20Z","abstract":[{"lang":"eng","text":"The mitochondrial respiratory chain, formed by five protein complexes, utilizes energy from catabolic processes to synthesize ATP. Complex I, the first and the largest protein complex of the chain, harvests electrons from NADH to reduce quinone, while pumping protons across the mitochondrial membrane. Detailed knowledge of the working principle of such coupled charge-transfer processes remains, however, fragmentary due to bottlenecks in understanding redox-driven conformational transitions and their interplay with the hydrated proton pathways. Complex I from Thermus thermophilus encases 16 subunits with nine iron–sulfur clusters, reduced by electrons from NADH. Here, employing the latest crystal structure of T. thermophilus complex I, we have used microsecond-scale molecular dynamics simulations to study the chemo-mechanical coupling between redox changes of the iron–sulfur clusters and conformational transitions across complex I. First, we identify the redox switches within complex I, which allosterically couple the dynamics of the quinone binding pocket to the site of NADH reduction. Second, our free-energy calculations reveal that the affinity of the quinone, specifically menaquinone, for the binding-site is higher than that of its reduced, menaquinol forma design essential for menaquinol release. Remarkably, the barriers to diffusive menaquinone dynamics are lesser than that of the more ubiquitous ubiquinone, and the naphthoquinone headgroup of the former furnishes stronger binding interactions with the pocket, favoring menaquinone for charge transport in T. thermophilus. Our computations are consistent with experimentally validated mutations and hierarchize the key residues into three functional classes, identifying new mutation targets. Third, long-range hydrogen-bond networks connecting the quinone-binding site to the transmembrane subunits are found to be responsible for proton pumping. Put together, the simulations reveal the molecular design principles linking redox reactions to quinone turnover to proton translocation in complex I."}],"oa_version":"Published Version","publisher":"American Chemical Society","main_file_link":[{"open_access":"1"}],"oa":1,"month":"05"},{"citation":{"mla":"Boccato, Chiara, et al. “The Excitation Spectrum of Bose Gases Interacting through Singular Potentials.” Journal of the European Mathematical Society, vol. 22, no. 7, European Mathematical Society, 2020, pp. 2331–403, doi:10.4171/JEMS/966.","apa":"Boccato, C., Brennecke, C., Cenatiempo, S., & Schlein, B. (2020). The excitation spectrum of Bose gases interacting through singular potentials. Journal of the European Mathematical Society. European Mathematical Society. https://doi.org/10.4171/JEMS/966","ama":"Boccato C, Brennecke C, Cenatiempo S, Schlein B. The excitation spectrum of Bose gases interacting through singular potentials. Journal of the European Mathematical Society. 2020;22(7):2331-2403. doi:10.4171/JEMS/966","short":"C. Boccato, C. Brennecke, S. Cenatiempo, B. Schlein, Journal of the European Mathematical Society 22 (2020) 2331–2403.","ieee":"C. Boccato, C. Brennecke, S. Cenatiempo, and B. Schlein, “The excitation spectrum of Bose gases interacting through singular potentials,” Journal of the European Mathematical Society, vol. 22, no. 7. European Mathematical Society, pp. 2331–2403, 2020.","chicago":"Boccato, Chiara, Christian Brennecke, Serena Cenatiempo, and Benjamin Schlein. “The Excitation Spectrum of Bose Gases Interacting through Singular Potentials.” Journal of the European Mathematical Society. European Mathematical Society, 2020. https://doi.org/10.4171/JEMS/966.","ista":"Boccato C, Brennecke C, Cenatiempo S, Schlein B. 2020. The excitation spectrum of Bose gases interacting through singular potentials. Journal of the European Mathematical Society. 22(7), 2331–2403."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000548174700006"],"arxiv":["1704.04819"]},"article_processing_charge":"No","author":[{"first_name":"Chiara","id":"342E7E22-F248-11E8-B48F-1D18A9856A87","full_name":"Boccato, Chiara","last_name":"Boccato"},{"first_name":"Christian","full_name":"Brennecke, Christian","last_name":"Brennecke"},{"first_name":"Serena","last_name":"Cenatiempo","full_name":"Cenatiempo, Serena"},{"first_name":"Benjamin","full_name":"Schlein, Benjamin","last_name":"Schlein"}],"title":"The excitation spectrum of Bose gases interacting through singular potentials","oa":1,"quality_controlled":"1","publisher":"European Mathematical Society","year":"2020","isi":1,"publication":"Journal of the European Mathematical Society","day":"01","page":"2331-2403","date_created":"2020-06-29T07:59:35Z","doi":"10.4171/JEMS/966","date_published":"2020-07-01T00:00:00Z","_id":"8042","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-08-22T07:47:04Z","department":[{"_id":"RoSe"}],"abstract":[{"lang":"eng","text":"We consider systems of N bosons in a box of volume one, interacting through a repulsive two-body potential of the form κN3β−1V(Nβx). For all 0<β<1, and for sufficiently small coupling constant κ>0, we establish the validity of Bogolyubov theory, identifying the ground state energy and the low-lying excitation spectrum up to errors that vanish in the limit of large N."}],"oa_version":"Preprint","main_file_link":[{"url":"https://arxiv.org/abs/1704.04819","open_access":"1"}],"scopus_import":"1","intvolume":" 22","month":"07","publication_status":"published","publication_identifier":{"issn":["14359855"]},"language":[{"iso":"eng"}],"issue":"7","volume":22},{"_id":"9713","type":"research_data_reference","status":"public","date_updated":"2023-08-22T07:49:38Z","citation":{"ista":"Gupta C, Khaniya U, Chan CK, Dehez F, Shekhar M, Gunner MR, Sazanov LA, Chipot C, Singharoy A. 2020. Supporting information, American Chemical Society , 10.1021/jacs.9b13450.s001.","chicago":"Gupta, Chitrak, Umesh Khaniya, Chun Kit Chan, Francois Dehez, Mrinal Shekhar, M.R. Gunner, Leonid A Sazanov, Christophe Chipot, and Abhishek Singharoy. “Supporting Information.” American Chemical Society , 2020. https://doi.org/10.1021/jacs.9b13450.s001.","ama":"Gupta C, Khaniya U, Chan CK, et al. Supporting information. 2020. doi:10.1021/jacs.9b13450.s001","apa":"Gupta, C., Khaniya, U., Chan, C. K., Dehez, F., Shekhar, M., Gunner, M. R., … Singharoy, A. (2020). Supporting information. American Chemical Society . https://doi.org/10.1021/jacs.9b13450.s001","short":"C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).","ieee":"C. Gupta et al., “Supporting information.” American Chemical Society , 2020.","mla":"Gupta, Chitrak, et al. Supporting Information. American Chemical Society , 2020, doi:10.1021/jacs.9b13450.s001."},"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","article_processing_charge":"No","author":[{"full_name":"Gupta, Chitrak","last_name":"Gupta","first_name":"Chitrak"},{"last_name":"Khaniya","full_name":"Khaniya, Umesh","first_name":"Umesh"},{"first_name":"Chun Kit","last_name":"Chan","full_name":"Chan, Chun Kit"},{"last_name":"Dehez","full_name":"Dehez, Francois","first_name":"Francois"},{"last_name":"Shekhar","full_name":"Shekhar, Mrinal","first_name":"Mrinal"},{"first_name":"M.R.","full_name":"Gunner, M.R.","last_name":"Gunner"},{"last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A"},{"first_name":"Christophe","full_name":"Chipot, Christophe","last_name":"Chipot"},{"first_name":"Abhishek","last_name":"Singharoy","full_name":"Singharoy, Abhishek"}],"title":"Supporting information","department":[{"_id":"LeSa"}],"abstract":[{"lang":"eng","text":"Additional analyses of the trajectories"}],"oa_version":"Published Version","publisher":"American Chemical Society ","month":"05","year":"2020","day":"20","date_created":"2021-07-23T12:02:39Z","related_material":{"record":[{"status":"public","id":"8040","relation":"used_in_publication"}]},"doi":"10.1021/jacs.9b13450.s001","date_published":"2020-05-20T00:00:00Z"},{"department":[{"_id":"LeSa"}],"title":"Movies","author":[{"first_name":"Chitrak","full_name":"Gupta, Chitrak","last_name":"Gupta"},{"first_name":"Umesh","full_name":"Khaniya, Umesh","last_name":"Khaniya"},{"last_name":"Chan","full_name":"Chan, Chun Kit","first_name":"Chun Kit"},{"last_name":"Dehez","full_name":"Dehez, Francois","first_name":"Francois"},{"first_name":"Mrinal","last_name":"Shekhar","full_name":"Shekhar, Mrinal"},{"full_name":"Gunner, M.R.","last_name":"Gunner","first_name":"M.R."},{"last_name":"Sazanov","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Christophe","full_name":"Chipot, Christophe","last_name":"Chipot"},{"last_name":"Singharoy","full_name":"Singharoy, Abhishek","first_name":"Abhishek"}],"article_processing_charge":"No","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","citation":{"chicago":"Gupta, Chitrak, Umesh Khaniya, Chun Kit Chan, Francois Dehez, Mrinal Shekhar, M.R. Gunner, Leonid A Sazanov, Christophe Chipot, and Abhishek Singharoy. “Movies.” American Chemical Society, 2020. https://doi.org/10.1021/jacs.9b13450.s002.","ista":"Gupta C, Khaniya U, Chan CK, Dehez F, Shekhar M, Gunner MR, Sazanov LA, Chipot C, Singharoy A. 2020. Movies, American Chemical Society, 10.1021/jacs.9b13450.s002.","mla":"Gupta, Chitrak, et al. Movies. American Chemical Society, 2020, doi:10.1021/jacs.9b13450.s002.","ama":"Gupta C, Khaniya U, Chan CK, et al. Movies. 2020. doi:10.1021/jacs.9b13450.s002","apa":"Gupta, C., Khaniya, U., Chan, C. K., Dehez, F., Shekhar, M., Gunner, M. R., … Singharoy, A. (2020). Movies. American Chemical Society. https://doi.org/10.1021/jacs.9b13450.s002","ieee":"C. Gupta et al., “Movies.” American Chemical Society, 2020.","short":"C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020)."},"date_updated":"2023-08-22T07:49:38Z","status":"public","type":"research_data_reference","_id":"9878","date_published":"2020-05-20T00:00:00Z","related_material":{"record":[{"id":"8040","status":"public","relation":"used_in_publication"}]},"doi":"10.1021/jacs.9b13450.s002","date_created":"2021-08-11T09:18:54Z","day":"20","year":"2020","month":"05","publisher":"American Chemical Society","oa_version":"Published Version"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Hippe, Andreas, Stephan Alexander Braun, Péter Oláh, Peter Arne Gerber, Anne Schorr, Stephan Seeliger, Stephanie Holtz, et al. “EGFR/Ras-Induced CCL20 Production Modulates the Tumour Microenvironment.” British Journal of Cancer. Springer Nature, 2020. https://doi.org/10.1038/s41416-020-0943-2.","ista":"Hippe A, Braun SA, Oláh P, Gerber PA, Schorr A, Seeliger S, Holtz S, Jannasch K, Pivarcsi A, Buhren B, Schrumpf H, Kislat A, Bünemann E, Steinhoff M, Fischer J, Lira SA, Boukamp P, Hevezi P, Stoecklein NH, Hoffmann T, Alves F, Sleeman J, Bauer T, Klufa J, Amberg N, Sibilia M, Zlotnik A, Müller-Homey A, Homey B. 2020. EGFR/Ras-induced CCL20 production modulates the tumour microenvironment. British Journal of Cancer. 123, 942–954.","mla":"Hippe, Andreas, et al. “EGFR/Ras-Induced CCL20 Production Modulates the Tumour Microenvironment.” British Journal of Cancer, vol. 123, Springer Nature, 2020, pp. 942–54, doi:10.1038/s41416-020-0943-2.","ama":"Hippe A, Braun SA, Oláh P, et al. EGFR/Ras-induced CCL20 production modulates the tumour microenvironment. British Journal of Cancer. 2020;123:942-954. doi:10.1038/s41416-020-0943-2","apa":"Hippe, A., Braun, S. A., Oláh, P., Gerber, P. A., Schorr, A., Seeliger, S., … Homey, B. (2020). EGFR/Ras-induced CCL20 production modulates the tumour microenvironment. British Journal of Cancer. Springer Nature. https://doi.org/10.1038/s41416-020-0943-2","ieee":"A. Hippe et al., “EGFR/Ras-induced CCL20 production modulates the tumour microenvironment,” British Journal of Cancer, vol. 123. Springer Nature, pp. 942–954, 2020.","short":"A. Hippe, S.A. Braun, P. Oláh, P.A. Gerber, A. Schorr, S. Seeliger, S. Holtz, K. Jannasch, A. Pivarcsi, B. Buhren, H. Schrumpf, A. Kislat, E. Bünemann, M. Steinhoff, J. Fischer, S.A. Lira, P. Boukamp, P. Hevezi, N.H. Stoecklein, T. Hoffmann, F. Alves, J. Sleeman, T. Bauer, J. Klufa, N. Amberg, M. Sibilia, A. Zlotnik, A. Müller-Homey, B. Homey, British Journal of Cancer 123 (2020) 942–954."},"title":"EGFR/Ras-induced CCL20 production modulates the tumour microenvironment","article_processing_charge":"No","external_id":{"isi":["000544152500001"],"pmid":["32601464"]},"author":[{"first_name":"Andreas","last_name":"Hippe","full_name":"Hippe, Andreas"},{"full_name":"Braun, Stephan Alexander","last_name":"Braun","first_name":"Stephan Alexander"},{"first_name":"Péter","last_name":"Oláh","full_name":"Oláh, Péter"},{"first_name":"Peter Arne","full_name":"Gerber, Peter Arne","last_name":"Gerber"},{"last_name":"Schorr","full_name":"Schorr, Anne","first_name":"Anne"},{"first_name":"Stephan","full_name":"Seeliger, Stephan","last_name":"Seeliger"},{"first_name":"Stephanie","last_name":"Holtz","full_name":"Holtz, Stephanie"},{"first_name":"Katharina","full_name":"Jannasch, Katharina","last_name":"Jannasch"},{"first_name":"Andor","full_name":"Pivarcsi, Andor","last_name":"Pivarcsi"},{"first_name":"Bettina","last_name":"Buhren","full_name":"Buhren, Bettina"},{"full_name":"Schrumpf, Holger","last_name":"Schrumpf","first_name":"Holger"},{"full_name":"Kislat, Andreas","last_name":"Kislat","first_name":"Andreas"},{"first_name":"Erich","last_name":"Bünemann","full_name":"Bünemann, Erich"},{"full_name":"Steinhoff, Martin","last_name":"Steinhoff","first_name":"Martin"},{"last_name":"Fischer","full_name":"Fischer, Jens","first_name":"Jens"},{"first_name":"Sérgio A.","full_name":"Lira, Sérgio A.","last_name":"Lira"},{"first_name":"Petra","full_name":"Boukamp, Petra","last_name":"Boukamp"},{"first_name":"Peter","full_name":"Hevezi, Peter","last_name":"Hevezi"},{"first_name":"Nikolas Hendrik","last_name":"Stoecklein","full_name":"Stoecklein, Nikolas Hendrik"},{"full_name":"Hoffmann, Thomas","last_name":"Hoffmann","first_name":"Thomas"},{"last_name":"Alves","full_name":"Alves, Frauke","first_name":"Frauke"},{"first_name":"Jonathan","full_name":"Sleeman, Jonathan","last_name":"Sleeman"},{"full_name":"Bauer, Thomas","last_name":"Bauer","first_name":"Thomas"},{"full_name":"Klufa, Jörg","last_name":"Klufa","first_name":"Jörg"},{"last_name":"Amberg","full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Maria","full_name":"Sibilia, Maria","last_name":"Sibilia"},{"full_name":"Zlotnik, Albert","last_name":"Zlotnik","first_name":"Albert"},{"first_name":"Anja","last_name":"Müller-Homey","full_name":"Müller-Homey, Anja"},{"last_name":"Homey","full_name":"Homey, Bernhard","first_name":"Bernhard"}],"acknowledgement":"The authors would like to thank A. van Lierop for technical assistance. In addition, we thank C. Dullin, J. Missbach-Güntner and S. Greco for advice and assistance with fpVCT imaging. Furthermore, the authors would like to thank H. K. Horst for advice on performing matrigel plug assays. This study has also been partially presented in A. Schorr’s doctoral thesis and the funding report of the SPP 1190 ‘The tumor-vessel interface’ of the ‘Deutsche Forschungsgemeinschaft’ (DFG).\r\nThis project was funded by the SPP 1190 “The tumor-vessel interface” and HO 2092/8-1 of the ‘Deutsche Forschungsgemeinschaft’ (DFG) to B. Homey. In addition, it was supported by grants from the Austrian Science Fund (FWF, W1212 to N. Amberg and J. Klufa and I4300-B to T. Bauer), the WWTF project LS16-025 and the European Research Council (ERC) Advanced grant (ERC-2015-AdG TNT-Tumors 694883) to M. Sibilia.","oa":1,"quality_controlled":"1","publisher":"Springer Nature","publication":"British Journal of Cancer","day":"15","year":"2020","isi":1,"has_accepted_license":"1","date_created":"2020-07-05T22:00:46Z","date_published":"2020-09-15T00:00:00Z","doi":"10.1038/s41416-020-0943-2","page":"942-954","_id":"8093","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","article_type":"original","ddc":["610"],"date_updated":"2023-08-22T07:51:12Z","department":[{"_id":"SiHi"}],"file_date_updated":"2021-12-02T12:35:12Z","oa_version":"Published Version","pmid":1,"abstract":[{"text":"Background: The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment.\r\nMethods: The effects of EGFR/Ras on the expression and translation of CCL20 were analysed in a large set of epithelial cancer cell lines and tumour tissues by RT-qPCR and ELISA in vitro. CCL20 production was verified by immunohistochemistry in different tumour tissues and correlated with clinical data. The effects of CCL20 on endothelial cell migration and tumour-associated vascularisation were comprehensively analysed with chemotaxis assays in vitro and in CCR6-deficient mice in vivo.\r\nResults: Tumours facilitate progression by the EGFR/Ras-induced production of CCL20. Expression of the chemokine CCL20 in tumours correlates with advanced tumour stage, increased lymph node metastasis and decreased survival in patients. Microvascular endothelial cells abundantly express the specific CCL20 receptor CCR6. CCR6 signalling in endothelial cells induces angiogenesis. CCR6-deficient mice show significantly decreased tumour growth and tumour-associated vascularisation. The observed phenotype is dependent on CCR6 deficiency in stromal cells but not within the immune system.\r\nConclusion: We propose that the chemokine axis CCL20–CCR6 represents a novel and promising target to interfere with the tumour microenvironment, and opens an innovative multimodal strategy for cancer therapy.","lang":"eng"}],"intvolume":" 123","month":"09","scopus_import":"1","language":[{"iso":"eng"}],"file":[{"file_size":3620691,"date_updated":"2021-12-02T12:35:12Z","creator":"cchlebak","file_name":"2020_BrJournalCancer_Hippe.pdf","date_created":"2021-12-02T12:35:12Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","success":1,"checksum":"05a8e65d49c3f5b8e37ac4afe68287e2","file_id":"10398"}],"publication_status":"published","publication_identifier":{"issn":["0007-0920"],"eissn":["1532-1827"]},"related_material":{"record":[{"id":"10170","status":"deleted","relation":"later_version"}],"link":[{"url":"https://doi.org/10.1038/s41416-021-01563-y","relation":"erratum"}]},"volume":123},{"doi":"10.1007/s10955-020-02586-0","date_published":"2020-10-01T00:00:00Z","date_created":"2020-07-05T22:00:46Z","page":"448-464","day":"01","publication":"Journal of Statistical Physics","isi":1,"has_accepted_license":"1","year":"2020","publisher":"Springer","quality_controlled":"1","oa":1,"acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria).\r\nThe work of R.S. was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No 694227). J.Y. gratefully acknowledges hospitality at the LPMMC Grenoble and valuable discussions with Alessandro Olgiati and Nicolas Rougerie. ","title":"Emergence of Haldane pseudo-potentials in systems with short-range interactions","author":[{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"last_name":"Yngvason","full_name":"Yngvason, Jakob","first_name":"Jakob"}],"article_processing_charge":"Yes (via OA deal)","external_id":{"arxiv":["2001.07144"],"isi":["000543030000002"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ista":"Seiringer R, Yngvason J. 2020. Emergence of Haldane pseudo-potentials in systems with short-range interactions. Journal of Statistical Physics. 181, 448–464.","chicago":"Seiringer, Robert, and Jakob Yngvason. “Emergence of Haldane Pseudo-Potentials in Systems with Short-Range Interactions.” Journal of Statistical Physics. Springer, 2020. https://doi.org/10.1007/s10955-020-02586-0.","ieee":"R. Seiringer and J. Yngvason, “Emergence of Haldane pseudo-potentials in systems with short-range interactions,” Journal of Statistical Physics, vol. 181. Springer, pp. 448–464, 2020.","short":"R. Seiringer, J. Yngvason, Journal of Statistical Physics 181 (2020) 448–464.","ama":"Seiringer R, Yngvason J. Emergence of Haldane pseudo-potentials in systems with short-range interactions. Journal of Statistical Physics. 2020;181:448-464. doi:10.1007/s10955-020-02586-0","apa":"Seiringer, R., & Yngvason, J. (2020). Emergence of Haldane pseudo-potentials in systems with short-range interactions. Journal of Statistical Physics. Springer. https://doi.org/10.1007/s10955-020-02586-0","mla":"Seiringer, Robert, and Jakob Yngvason. “Emergence of Haldane Pseudo-Potentials in Systems with Short-Range Interactions.” Journal of Statistical Physics, vol. 181, Springer, 2020, pp. 448–64, doi:10.1007/s10955-020-02586-0."},"project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"},{"name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"}],"volume":181,"ec_funded":1,"file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"8812","checksum":"5cbeef52caf18d0d952f17fed7b5545a","success":1,"creator":"dernst","date_updated":"2020-11-25T15:05:04Z","file_size":404778,"date_created":"2020-11-25T15:05:04Z","file_name":"2020_JourStatPhysics_Seiringer.pdf"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["00224715"],"eissn":["15729613"]},"publication_status":"published","month":"10","intvolume":" 181","scopus_import":"1","oa_version":"Published Version","abstract":[{"text":"In the setting of the fractional quantum Hall effect we study the effects of strong, repulsive two-body interaction potentials of short range. We prove that Haldane’s pseudo-potential operators, including their pre-factors, emerge as mathematically rigorous limits of such interactions when the range of the potential tends to zero while its strength tends to infinity. In a common approach the interaction potential is expanded in angular momentum eigenstates in the lowest Landau level, which amounts to taking the pre-factors to be the moments of the potential. Such a procedure is not appropriate for very strong interactions, however, in particular not in the case of hard spheres. We derive the formulas valid in the short-range case, which involve the scattering lengths of the interaction potential in different angular momentum channels rather than its moments. Our results hold for bosons and fermions alike and generalize previous results in [6], which apply to bosons in the lowest angular momentum channel. Our main theorem asserts the convergence in a norm-resolvent sense of the Hamiltonian on the whole Hilbert space, after appropriate energy scalings, to Hamiltonians with contact interactions in the lowest Landau level.","lang":"eng"}],"file_date_updated":"2020-11-25T15:05:04Z","department":[{"_id":"RoSe"}],"ddc":["530"],"date_updated":"2023-08-22T07:51:47Z","status":"public","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"_id":"8091"}]