@article{627,
abstract = {Beige adipocytes are a new type of recruitable brownish adipocytes, with highly mitochondrial membrane uncoupling protein 1 expression and thermogenesis. Beige adipocytes were found among white adipocytes, especially in subcutaneous white adipose tissue (sWAT). Therefore, beige adipocytes may be involved in the regulation of energy metabolism and fat deposition. Transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the thermogenic function of brown adiposytes. However, the involvement of TRPM8 in the thermogenic function of WAT remains unexplored. Our data revealed that TRPM8 was expressed in mouse white adipocytes at mRNA, protein and functional levels. The mRNA expression of Trpm8 was significantly increased in the differentiated white adipocytes than pre-adipocytes. Moreover, activation of TRPM8 by menthol enhanced the expression of thermogenic genes in cultured white aidpocytes. And menthol-induced increases of the thermogenic genes in white adipocytes was inhibited by either KT5720 (a protein kinase A inhibitor) or BAPTA-AM. In addition, high fat diet (HFD)-induced obesity in mice was significantly recovered by co-treatment with menthol. Dietary menthol enhanced WAT "browning" and improved glucose metabolism in HFD-induced obesity mice as well. Therefore, we concluded that TRPM8 might be involved in WAT "browning" by increasing the expression levels of genes related to thermogenesis and energy metabolism. And dietary menthol could be a novel approach for combating human obesity and related metabolic diseases.},
author = {Jiang, Changyu and Zhai, Ming-Zhu and Yan, Dong and Li, Da and Li, Chen and Zhang, Yonghong and Xiao, Lizu and Xiong, Donglin and Deng, Qiwen and Sun, Wuping},
issn = {19492553},
journal = {Oncotarget},
number = {43},
pages = {75114 -- 75126},
publisher = {Impact Journals LLC},
title = {{Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates diet-induced obesity}},
doi = {10.18632/oncotarget.20540},
volume = {8},
year = {2017},
}
@inproceedings{628,
abstract = {We consider the problem of developing automated techniques for solving recurrence relations to aid the expected-runtime analysis of programs. The motivation is that several classical textbook algorithms have quite efficient expected-runtime complexity, whereas the corresponding worst-case bounds are either inefficient (e.g., Quick-Sort), or completely ineffective (e.g., Coupon-Collector). Since the main focus of expected-runtime analysis is to obtain efficient bounds, we consider bounds that are either logarithmic, linear or almost-linear (O(log n), O(n), O(n · log n), respectively, where n represents the input size). Our main contribution is an efficient (simple linear-time algorithm) sound approach for deriving such expected-runtime bounds for the analysis of recurrence relations induced by randomized algorithms. The experimental results show that our approach can efficiently derive asymptotically optimal expected-runtime bounds for recurrences of classical randomized algorithms, including Randomized-Search, Quick-Sort, Quick-Select, Coupon-Collector, where the worst-case bounds are either inefficient (such as linear as compared to logarithmic expected-runtime complexity, or quadratic as compared to linear or almost-linear expected-runtime complexity), or ineffective.},
author = {Chatterjee, Krishnendu and Fu, Hongfei and Murhekar, Aniket},
editor = {Majumdar, Rupak and Kunčak, Viktor},
isbn = {978-331963386-2},
location = {Heidelberg, Germany},
pages = {118 -- 139},
publisher = {Springer},
title = {{Automated recurrence analysis for almost linear expected runtime bounds}},
doi = {10.1007/978-3-319-63387-9_6},
volume = {10426},
year = {2017},
}
@inproceedings{637,
abstract = {For many cryptographic primitives, it is relatively easy to achieve selective security (where the adversary commits a-priori to some of the choices to be made later in the attack) but appears difficult to achieve the more natural notion of adaptive security (where the adversary can make all choices on the go as the attack progresses). A series of several recent works shows how to cleverly achieve adaptive security in several such scenarios including generalized selective decryption (Panjwani, TCC ’07 and Fuchsbauer et al., CRYPTO ’15), constrained PRFs (Fuchsbauer et al., ASIACRYPT ’14), and Yao garbled circuits (Jafargholi and Wichs, TCC ’16b). Although the above works expressed vague intuition that they share a common technique, the connection was never made precise. In this work we present a new framework that connects all of these works and allows us to present them in a unified and simplified fashion. Moreover, we use the framework to derive a new result for adaptively secure secret sharing over access structures defined via monotone circuits. We envision that further applications will follow in the future. Underlying our framework is the following simple idea. It is well known that selective security, where the adversary commits to n-bits of information about his future choices, automatically implies adaptive security at the cost of amplifying the adversary’s advantage by a factor of up to 2n. However, in some cases the proof of selective security proceeds via a sequence of hybrids, where each pair of adjacent hybrids locally only requires some smaller partial information consisting of m ≪ n bits. The partial information needed might be completely different between different pairs of hybrids, and if we look across all the hybrids we might rely on the entire n-bit commitment. Nevertheless, the above is sufficient to prove adaptive security, at the cost of amplifying the adversary’s advantage by a factor of only 2m ≪ 2n. In all of our examples using the above framework, the different hybrids are captured by some sort of a graph pebbling game and the amount of information that the adversary needs to commit to in each pair of hybrids is bounded by the maximum number of pebbles in play at any point in time. Therefore, coming up with better strategies for proving adaptive security translates to various pebbling strategies for different types of graphs.},
author = {Jafargholi, Zahra and Kamath Hosdurg, Chethan and Klein, Karen and Komargodski, Ilan and Pietrzak, Krzysztof Z and Wichs, Daniel},
editor = {Katz, Jonathan and Shacham, Hovav},
isbn = {978-331963687-0},
location = {Santa Barbara, CA, United States},
pages = {133 -- 163},
publisher = {Springer},
title = {{Be adaptive avoid overcommitting}},
doi = {10.1007/978-3-319-63688-7_5},
volume = {10401},
year = {2017},
}
@proceedings{638,
editor = {Bogomolov, Sergiy and Martel, Matthieu and Prabhakar, Pavithra},
publisher = {Springer},
title = {{Numerical Software Verification}},
doi = {10.1007/978-3-319-54292-8},
volume = {10152},
year = {2017},
}
@inproceedings{636,
abstract = {Signal regular expressions can specify sequential properties of real-valued signals based on threshold conditions, regular operations, and duration constraints. In this paper we endow them with a quantitative semantics which indicates how robustly a signal matches or does not match a given expression. First, we show that this semantics is a safe approximation of a distance between the signal and the language defined by the expression. Then, we consider the robust matching problem, that is, computing the quantitative semantics of every segment of a given signal relative to an expression. We present an algorithm that solves this problem for piecewise-constant and piecewise-linear signals and show that for such signals the robustness map is a piecewise-linear function. The availability of an indicator describing how robustly a signal segment matches some regular pattern provides a general framework for quantitative monitoring of cyber-physical systems.},
author = {Bakhirkin, Alexey and Ferrere, Thomas and Maler, Oded and Ulus, Dogan},
editor = {Abate, Alessandro and Geeraerts, Gilles},
isbn = {978-331965764-6},
location = {Berlin, Germany},
pages = {189 -- 206},
publisher = {Springer},
title = {{On the quantitative semantics of regular expressions over real-valued signals}},
doi = {10.1007/978-3-319-65765-3_11},
volume = {10419},
year = {2017},
}
@inproceedings{640,
abstract = {Data-independent Memory Hard Functions (iMHFS) are finding a growing number of applications in security; especially in the domain of password hashing. An important property of a concrete iMHF is specified by fixing a directed acyclic graph (DAG) Gn on n nodes. The quality of that iMHF is then captured by the following two pebbling complexities of Gn: – The parallel cumulative pebbling complexity Π∥cc(Gn) must be as high as possible (to ensure that the amortized cost of computing the function on dedicated hardware is dominated by the cost of memory). – The sequential space-time pebbling complexity Πst(Gn) should be as close as possible to Π∥cc(Gn) (to ensure that using many cores in parallel and amortizing over many instances does not give much of an advantage). In this paper we construct a family of DAGs with best possible parameters in an asymptotic sense, i.e., where Π∥cc(Gn) = Ω(n2/ log(n)) (which matches a known upper bound) and Πst(Gn) is within a constant factor of Π∥cc(Gn). Our analysis relies on a new connection between the pebbling complexity of a DAG and its depth-robustness (DR) – a well studied combinatorial property. We show that high DR is sufficient for high Π∥cc. Alwen and Blocki (CRYPTO’16) showed that high DR is necessary and so, together, these results fully characterize DAGs with high Π∥cc in terms of DR. Complementing these results, we provide new upper and lower bounds on the Π∥cc of several important candidate iMHFs from the literature. We give the first lower bounds on the memory hardness of the Catena and Balloon Hashing functions in a parallel model of computation and we give the first lower bounds of any kind for (a version) of Argon2i. Finally we describe a new class of pebbling attacks improving on those of Alwen and Blocki (CRYPTO’16). By instantiating these attacks we upperbound the Π∥cc of the Password Hashing Competition winner Argon2i and one of the Balloon Hashing functions by O (n1.71). We also show an upper bound of O(n1.625) for the Catena functions and the two remaining Balloon Hashing functions.},
author = {Alwen, Joel F and Blocki, Jeremiah and Pietrzak, Krzysztof Z},
editor = {Coron, Jean-Sébastien and Buus Nielsen, Jesper},
isbn = {978-331956616-0},
location = {Paris, France},
pages = {3 -- 32},
publisher = {Springer},
title = {{Depth-robust graphs and their cumulative memory complexity}},
doi = {10.1007/978-3-319-56617-7_1},
volume = {10212},
year = {2017},
}
@inproceedings{641,
abstract = {We introduce two novel methods for learning parameters of graphical models for image labelling. The following two tasks underline both methods: (i) perturb model parameters based on given features and ground truth labelings, so as to exactly reproduce these labelings as optima of the local polytope relaxation of the labelling problem; (ii) train a predictor for the perturbed model parameters so that improved model parameters can be applied to the labelling of novel data. Our first method implements task (i) by inverse linear programming and task (ii) using a regressor e.g. a Gaussian process. Our second approach simultaneously solves tasks (i) and (ii) in a joint manner, while being restricted to linearly parameterised predictors. Experiments demonstrate the merits of both approaches.},
author = {Trajkovska, Vera and Swoboda, Paul and Åström, Freddie and Petra, Stefanie},
editor = {Lauze, François and Dong, Yiqiu and Bjorholm Dahl, Anders},
isbn = {978-331958770-7},
location = {Kolding, Denmark},
pages = {323 -- 334},
publisher = {Springer},
title = {{Graphical model parameter learning by inverse linear programming}},
doi = {10.1007/978-3-319-58771-4_26},
volume = {10302},
year = {2017},
}
@misc{6426,
abstract = {Synchronous programs are easy to specify because the side effects of an operation are finished by the time the invocation of the operation returns to the caller. Asynchronous programs, on the other hand, are difficult to specify because there are side effects due to pending computation scheduled as a result of the invocation of an operation. They are also difficult to verify because of the large number of possible interleavings of concurrent asynchronous computation threads. We show that specifications and correctness proofs for asynchronous programs can be structured by introducing the fiction, for proof purposes, that intermediate, non-quiescent states of asynchronous operations can be ignored. Then, the task of specification becomes relatively simple and the task of verification can be naturally decomposed into smaller sub-tasks. The sub-tasks iteratively summarize, guided by the structure of an asynchronous program, the atomic effect of non-atomic operations and the synchronous effect of asynchronous operations. This structuring of specifications and proofs corresponds to the introduction of multiple layers of stepwise refinement for asynchronous programs. We present the first proof rule, called synchronization, to reduce asynchronous invocations on a lower layer to synchronous invocations on a higher layer. We implemented our proof method in CIVL and evaluated it on a collection of benchmark programs.},
author = {Henzinger, Thomas A and Kragl, Bernhard and Qadeer, Shaz},
issn = {2664-1690},
pages = {28},
publisher = {IST Austria},
title = {{Synchronizing the asynchronous}},
doi = {10.15479/AT:IST-2018-853-v2-2},
year = {2017},
}
@article{643,
abstract = {It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT) were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H2O2 levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H2O2 generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.},
author = {Sun, Wuping and Zhai, Ming-Zhu and Zhou, Qian and Qian, Chengrui and Jiang, Changyu},
issn = {03044920},
journal = {Chinese Journal of Physiology},
number = {4},
pages = {207 -- 214},
publisher = {Chinese Physiological Society},
title = {{Effects of B vitamins overload on plasma insulin level and hydrogen peroxide generation in rats}},
doi = {10.4077/CJP.2017.BAF469},
volume = {60},
year = {2017},
}
@article{642,
abstract = {Cauchy problems with SPDEs on the whole space are localized to Cauchy problems on a ball of radius R. This localization reduces various kinds of spatial approximation schemes to finite dimensional problems. The error is shown to be exponentially small. As an application, a numerical scheme is presented which combines the localization and the space and time discretization, and thus is fully implementable.},
author = {Gerencser, Mate and Gyöngy, István},
issn = {00255718},
journal = {Mathematics of Computation},
number = {307},
pages = {2373 -- 2397},
publisher = {American Mathematical Society},
title = {{Localization errors in solving stochastic partial differential equations in the whole space}},
doi = {10.1090/mcom/3201},
volume = {86},
year = {2017},
}