---
_id: '11961'
abstract:
- lang: eng
text: Flow chemistry involves the use of channels or tubing to conduct a reaction
in a continuous stream rather than in a flask. Flow equipment provides chemists
with unique control over reaction parameters enhancing reactivity or in some cases
enabling new reactions. This relatively young technology has received a remarkable
amount of attention in the past decade with many reports on what can be done in
flow. Until recently, however, the question, “Should we do this in flow?” has
merely been an afterthought. This review introduces readers to the basic principles
and fundamentals of flow chemistry and critically discusses recent flow chemistry
accounts.
article_processing_charge: No
article_type: original
author:
- first_name: Matthew B.
full_name: Plutschack, Matthew B.
last_name: Plutschack
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Kerry
full_name: Gilmore, Kerry
last_name: Gilmore
- first_name: Peter H.
full_name: Seeberger, Peter H.
last_name: Seeberger
citation:
ama: Plutschack MB, Pieber B, Gilmore K, Seeberger PH. The Hitchhiker’s Guide to
flow chemistry. Chemical Reviews. 2017;117(18):11796-11893. doi:10.1021/acs.chemrev.7b00183
apa: Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017).
The Hitchhiker’s Guide to flow chemistry. Chemical Reviews. American Chemical
Society. https://doi.org/10.1021/acs.chemrev.7b00183
chicago: Plutschack, Matthew B., Bartholomäus Pieber, Kerry Gilmore, and Peter H.
Seeberger. “The Hitchhiker’s Guide to Flow Chemistry.” Chemical Reviews.
American Chemical Society, 2017. https://doi.org/10.1021/acs.chemrev.7b00183.
ieee: M. B. Plutschack, B. Pieber, K. Gilmore, and P. H. Seeberger, “The Hitchhiker’s
Guide to flow chemistry,” Chemical Reviews, vol. 117, no. 18. American
Chemical Society, pp. 11796–11893, 2017.
ista: Plutschack MB, Pieber B, Gilmore K, Seeberger PH. 2017. The Hitchhiker’s Guide
to flow chemistry. Chemical Reviews. 117(18), 11796–11893.
mla: Plutschack, Matthew B., et al. “The Hitchhiker’s Guide to Flow Chemistry.”
Chemical Reviews, vol. 117, no. 18, American Chemical Society, 2017, pp.
11796–893, doi:10.1021/acs.chemrev.7b00183.
short: M.B. Plutschack, B. Pieber, K. Gilmore, P.H. Seeberger, Chemical Reviews
117 (2017) 11796–11893.
date_created: 2022-08-24T11:07:46Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-02-21T10:09:28Z
day: '01'
doi: 10.1021/acs.chemrev.7b00183
extern: '1'
external_id:
pmid:
- '28570059'
intvolume: ' 117'
issue: '18'
language:
- iso: eng
month: '06'
oa_version: None
page: 11796-11893
pmid: 1
publication: Chemical Reviews
publication_identifier:
eissn:
- 1520-6890
issn:
- 0009-2665
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Hitchhiker’s Guide to flow chemistry
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2017'
...
---
_id: '11976'
abstract:
- lang: eng
text: The way organic multistep synthesis is performed is changing due to the adoption
of flow chemical techniques, which has enabled the development of improved methods
to make complex molecules. The modular nature of the technique provides not only
access to target molecules via linear flow approaches but also for the targeting
of structural cores with single systems. This perspective article summarizes the
state of the art of continuous multistep synthesis and discusses the main challenges
and opportunities in this area.
article_processing_charge: No
article_type: original
author:
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Kerry
full_name: Gilmore, Kerry
last_name: Gilmore
- first_name: Peter H.
full_name: Seeberger, Peter H.
last_name: Seeberger
citation:
ama: Pieber B, Gilmore K, Seeberger PH. Integrated flow processing - challenges
in continuous multistep synthesis. Journal of Flow Chemistry. 2017;7(3-4):129-136.
doi:10.1556/1846.2017.00016
apa: Pieber, B., Gilmore, K., & Seeberger, P. H. (2017). Integrated flow processing
- challenges in continuous multistep synthesis. Journal of Flow Chemistry.
AKJournals. https://doi.org/10.1556/1846.2017.00016
chicago: Pieber, Bartholomäus, Kerry Gilmore, and Peter H. Seeberger. “Integrated
Flow Processing - Challenges in Continuous Multistep Synthesis.” Journal of
Flow Chemistry. AKJournals, 2017. https://doi.org/10.1556/1846.2017.00016.
ieee: B. Pieber, K. Gilmore, and P. H. Seeberger, “Integrated flow processing -
challenges in continuous multistep synthesis,” Journal of Flow Chemistry,
vol. 7, no. 3–4. AKJournals, pp. 129–136, 2017.
ista: Pieber B, Gilmore K, Seeberger PH. 2017. Integrated flow processing - challenges
in continuous multistep synthesis. Journal of Flow Chemistry. 7(3–4), 129–136.
mla: Pieber, Bartholomäus, et al. “Integrated Flow Processing - Challenges in Continuous
Multistep Synthesis.” Journal of Flow Chemistry, vol. 7, no. 3–4, AKJournals,
2017, pp. 129–36, doi:10.1556/1846.2017.00016.
short: B. Pieber, K. Gilmore, P.H. Seeberger, Journal of Flow Chemistry 7 (2017)
129–136.
date_created: 2022-08-25T10:47:51Z
date_published: 2017-09-01T00:00:00Z
date_updated: 2023-02-21T10:10:02Z
day: '01'
doi: 10.1556/1846.2017.00016
extern: '1'
intvolume: ' 7'
issue: 3-4
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1556/1846.2017.00016
month: '09'
oa: 1
oa_version: Published Version
page: 129-136
publication: Journal of Flow Chemistry
publication_identifier:
eissn:
- 2063-0212
issn:
- 2062-249X
publication_status: published
publisher: AKJournals
quality_controlled: '1'
scopus_import: '1'
status: public
title: Integrated flow processing - challenges in continuous multistep synthesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2017'
...
---
_id: '1211'
abstract:
- lang: eng
text: Systems such as fluid flows in channels and pipes or the complex Ginzburg–Landau
system, defined over periodic domains, exhibit both continuous symmetries, translational
and rotational, as well as discrete symmetries under spatial reflections or complex
conjugation. The simplest, and very common symmetry of this type is the equivariance
of the defining equations under the orthogonal group O(2). We formulate a novel
symmetry reduction scheme for such systems by combining the method of slices with
invariant polynomial methods, and show how it works by applying it to the Kuramoto–Sivashinsky
system in one spatial dimension. As an example, we track a relative periodic orbit
through a sequence of bifurcations to the onset of chaos. Within the symmetry-reduced
state space we are able to compute and visualize the unstable manifolds of relative
periodic orbits, their torus bifurcations, a transition to chaos via torus breakdown,
and heteroclinic connections between various relative periodic orbits. It would
be very hard to carry through such analysis in the full state space, without a
symmetry reduction such as the one we present here.
acknowledgement: 'This work was supported by the family of late G. Robinson, Jr. and
NSF Grant DMS-1211827. '
author:
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
- first_name: Predrag
full_name: Cvitanović, Predrag
last_name: Cvitanović
citation:
ama: Budanur NB, Cvitanović P. Unstable manifolds of relative periodic orbits in
the symmetry reduced state space of the Kuramoto–Sivashinsky system. Journal
of Statistical Physics. 2017;167(3-4):636-655. doi:10.1007/s10955-016-1672-z
apa: Budanur, N. B., & Cvitanović, P. (2017). Unstable manifolds of relative
periodic orbits in the symmetry reduced state space of the Kuramoto–Sivashinsky
system. Journal of Statistical Physics. Springer. https://doi.org/10.1007/s10955-016-1672-z
chicago: Budanur, Nazmi B, and Predrag Cvitanović. “Unstable Manifolds of Relative
Periodic Orbits in the Symmetry Reduced State Space of the Kuramoto–Sivashinsky
System.” Journal of Statistical Physics. Springer, 2017. https://doi.org/10.1007/s10955-016-1672-z.
ieee: N. B. Budanur and P. Cvitanović, “Unstable manifolds of relative periodic
orbits in the symmetry reduced state space of the Kuramoto–Sivashinsky system,”
Journal of Statistical Physics, vol. 167, no. 3–4. Springer, pp. 636–655,
2017.
ista: Budanur NB, Cvitanović P. 2017. Unstable manifolds of relative periodic orbits
in the symmetry reduced state space of the Kuramoto–Sivashinsky system. Journal
of Statistical Physics. 167(3–4), 636–655.
mla: Budanur, Nazmi B., and Predrag Cvitanović. “Unstable Manifolds of Relative
Periodic Orbits in the Symmetry Reduced State Space of the Kuramoto–Sivashinsky
System.” Journal of Statistical Physics, vol. 167, no. 3–4, Springer, 2017,
pp. 636–55, doi:10.1007/s10955-016-1672-z.
short: N.B. Budanur, P. Cvitanović, Journal of Statistical Physics 167 (2017) 636–655.
date_created: 2018-12-11T11:50:44Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2021-01-12T06:49:07Z
day: '01'
ddc:
- '530'
department:
- _id: BjHo
doi: 10.1007/s10955-016-1672-z
file:
- access_level: open_access
checksum: 3e971d09eb167761aa0888ed415b0056
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:01Z
date_updated: 2020-07-14T12:44:39Z
file_id: '5319'
file_name: IST-2017-782-v1+1_BudCvi15.pdf
file_size: 2820207
relation: main_file
file_date_updated: 2020-07-14T12:44:39Z
has_accepted_license: '1'
intvolume: ' 167'
issue: 3-4
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 636-655
publication: Journal of Statistical Physics
publication_status: published
publisher: Springer
publist_id: '6136'
pubrep_id: '782'
quality_controlled: '1'
scopus_import: 1
status: public
title: Unstable manifolds of relative periodic orbits in the symmetry reduced state
space of the Kuramoto–Sivashinsky system
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 167
year: '2017'
...
---
_id: '123'
abstract:
- lang: eng
text: The Leidenfrost effect occurs when an object near a hot surface vaporizes
rapidly enough to lift itself up and hover. Although well understood for liquids
and stiff sublimable solids, nothing is known about the effect with materials
whose stiffness lies between these extremes. Here we introduce a new phenomenon
that occurs with vaporizable soft solids - the elastic Leidenfrost effect. By
dropping hydrogel spheres onto hot surfaces we find that, rather than hovering,
they energetically bounce several times their diameter for minutes at a time.
With high-speed video during a single impact, we uncover high-frequency microscopic
gap dynamics at the sphere/substrate interface. We show how these otherwise-hidden
agitations constitute work cycles that harvest mechanical energy from the vapour
and sustain the bouncing. Our findings suggest a new strategy for injecting mechanical
energy into a widely used class of soft materials, with potential relevance to
fields such as active matter, soft robotics and microfluidics.
acknowledgement: A.S. acknowledges funding from the Delta Institute for Theoretical
Physics and the hospitality of the IBS Center for Theoretical Physics of Complex
Systems, Daejeon, South Korea. We acknowledge funding from the Netherlands Organisation
for Scientific Research through grants VICI No. NWO-680-47-609 (M.v.H. and S.R.W.),
VENI No. NWO-680-47-445 (C.C.) and VENI No. NWO-680-47-453 (S.R.W.).
author:
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
- first_name: Antal
full_name: Zuiderwijk, Antal
last_name: Zuiderwijk
- first_name: Anton
full_name: Souslov, Anton
last_name: Souslov
- first_name: Corentin
full_name: Coulais, Corentin
last_name: Coulais
- first_name: Martin
full_name: Van Hecke, Martin
last_name: Van Hecke
citation:
ama: Waitukaitis SR, Zuiderwijk A, Souslov A, Coulais C, Van Hecke M. Coupling the
Leidenfrost effect and elastic deformations to power sustained bouncing. Nature
Physics. 2017;13(11):1095-1099. doi:10.1038/nphys4194
apa: Waitukaitis, S. R., Zuiderwijk, A., Souslov, A., Coulais, C., & Van Hecke,
M. (2017). Coupling the Leidenfrost effect and elastic deformations to power sustained
bouncing. Nature Physics. Nature Publishing Group. https://doi.org/10.1038/nphys4194
chicago: Waitukaitis, Scott R, Antal Zuiderwijk, Anton Souslov, Corentin Coulais,
and Martin Van Hecke. “Coupling the Leidenfrost Effect and Elastic Deformations
to Power Sustained Bouncing.” Nature Physics. Nature Publishing Group,
2017. https://doi.org/10.1038/nphys4194.
ieee: S. R. Waitukaitis, A. Zuiderwijk, A. Souslov, C. Coulais, and M. Van Hecke,
“Coupling the Leidenfrost effect and elastic deformations to power sustained bouncing,”
Nature Physics, vol. 13, no. 11. Nature Publishing Group, pp. 1095–1099,
2017.
ista: Waitukaitis SR, Zuiderwijk A, Souslov A, Coulais C, Van Hecke M. 2017. Coupling
the Leidenfrost effect and elastic deformations to power sustained bouncing. Nature
Physics. 13(11), 1095–1099.
mla: Waitukaitis, Scott R., et al. “Coupling the Leidenfrost Effect and Elastic
Deformations to Power Sustained Bouncing.” Nature Physics, vol. 13, no.
11, Nature Publishing Group, 2017, pp. 1095–99, doi:10.1038/nphys4194.
short: S.R. Waitukaitis, A. Zuiderwijk, A. Souslov, C. Coulais, M. Van Hecke, Nature
Physics 13 (2017) 1095–1099.
date_created: 2018-12-11T11:44:45Z
date_published: 2017-07-24T00:00:00Z
date_updated: 2021-01-12T06:49:14Z
day: '24'
doi: 10.1038/nphys4194
extern: '1'
external_id:
arxiv:
- '1705.03530'
intvolume: ' 13'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1705.03530
month: '07'
oa: 1
oa_version: Preprint
page: 1095 - 1099
publication: Nature Physics
publication_status: published
publisher: Nature Publishing Group
publist_id: '7931'
quality_controlled: '1'
status: public
title: Coupling the Leidenfrost effect and elastic deformations to power sustained
bouncing
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2017'
...
---
_id: '12571'
abstract:
- lang: eng
text: We consider the problems of maintaining approximate maximum matching and minimum
vertex cover in a dynamic graph. Starting with the seminal work of Onak and Rubinfeld
[STOC 2010], this problem has received significant attention in recent years.
Very recently, extending the framework of Baswana, Gupta and Sen [FOCS 2011],
Solomon [FOCS 2016] gave a randomized 2-approximation dynamic algorithm for this
problem that has amortized update time of O(1) with high probability. We consider
the natural open question of derandomizing this result. We present a new deterministic
fully dynamic algorithm that maintains a O(1)-approximate minimum vertex cover
and maximum fractional matching, with an amortized update time of O(1). Previously,
the best deterministic algorithm for this problem was due to Bhattacharya, Henzinger
and Italiano [SODA 2015]; it had an approximation ratio of (2+ϵ) and an amortized
update time of O(logn/ϵ2). Our result can be generalized to give a fully dynamic
O(f3)-approximation algorithm with O(f2) amortized update time for the hypergraph
vertex cover and fractional matching problems, where every hyperedge has at most
f vertices.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Deeparnab
full_name: Chakrabarty, Deeparnab
last_name: Chakrabarty
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Bhattacharya S, Chakrabarty D, Henzinger MH. Deterministic fully dynamic approximate
vertex cover and fractional matching in O(1) amortized update time. In: 19th
International Conference on Integer Programming and Combinatorial Optimization.
Vol 10328. Springer Nature; 2017:86-98. doi:10.1007/978-3-319-59250-3_8'
apa: 'Bhattacharya, S., Chakrabarty, D., & Henzinger, M. H. (2017). Deterministic
fully dynamic approximate vertex cover and fractional matching in O(1) amortized
update time. In 19th International Conference on Integer Programming and Combinatorial
Optimization (Vol. 10328, pp. 86–98). Waterloo, ON, Canada: Springer Nature.
https://doi.org/10.1007/978-3-319-59250-3_8'
chicago: Bhattacharya, Sayan, Deeparnab Chakrabarty, and Monika H Henzinger. “Deterministic
Fully Dynamic Approximate Vertex Cover and Fractional Matching in O(1) Amortized
Update Time.” In 19th International Conference on Integer Programming and Combinatorial
Optimization, 10328:86–98. Springer Nature, 2017. https://doi.org/10.1007/978-3-319-59250-3_8.
ieee: S. Bhattacharya, D. Chakrabarty, and M. H. Henzinger, “Deterministic fully
dynamic approximate vertex cover and fractional matching in O(1) amortized update
time,” in 19th International Conference on Integer Programming and Combinatorial
Optimization, Waterloo, ON, Canada, 2017, vol. 10328, pp. 86–98.
ista: 'Bhattacharya S, Chakrabarty D, Henzinger MH. 2017. Deterministic fully dynamic
approximate vertex cover and fractional matching in O(1) amortized update time.
19th International Conference on Integer Programming and Combinatorial Optimization.
IPCO: Integer Programming and Combinatorial Optimization, LNCS, vol. 10328, 86–98.'
mla: Bhattacharya, Sayan, et al. “Deterministic Fully Dynamic Approximate Vertex
Cover and Fractional Matching in O(1) Amortized Update Time.” 19th International
Conference on Integer Programming and Combinatorial Optimization, vol. 10328,
Springer Nature, 2017, pp. 86–98, doi:10.1007/978-3-319-59250-3_8.
short: S. Bhattacharya, D. Chakrabarty, M.H. Henzinger, in:, 19th International
Conference on Integer Programming and Combinatorial Optimization, Springer Nature,
2017, pp. 86–98.
conference:
end_date: 2017-06-28
location: Waterloo, ON, Canada
name: 'IPCO: Integer Programming and Combinatorial Optimization'
start_date: 2017-06-26
date_created: 2023-02-20T07:52:31Z
date_published: 2017-05-24T00:00:00Z
date_updated: 2023-02-20T07:57:24Z
day: '24'
doi: 10.1007/978-3-319-59250-3_8
extern: '1'
external_id:
arxiv:
- '1611.00198'
intvolume: ' 10328'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1611.00198
month: '05'
oa: 1
oa_version: Preprint
page: 86-98
publication: 19th International Conference on Integer Programming and Combinatorial
Optimization
publication_identifier:
eisbn:
- '9783319592503'
isbn:
- '9783319592497'
issn:
- 0302-9743
- 1611-3349
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deterministic fully dynamic approximate vertex cover and fractional matching
in O(1) amortized update time
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10328
year: '2017'
...