---
_id: '743'
abstract:
- lang: eng
text: "This special issue of the Journal on Formal Methods in System Design is dedicated
to Prof. Helmut Veith, who unexpectedly passed away in March 2016. Helmut Veith
was a brilliant researcher, inspiring collaborator, passionate mentor, generous
friend, and valued member of the formal methods community. Helmut was not only
known for his numerous and influential contributions in the field of automated
verification (most prominently his work on Counterexample-Guided Abstraction Refinement
[1,2]), but also for his untiring and passionate efforts for the logic community:
he co-organized the Vienna Summer of Logic (an event comprising twelve conferences
and numerous workshops which attracted thousands of researchers from all over
the world), he initiated the Vienna Center for Logic and Algorithms (which promotes
international collaboration on logic and algorithms and organizes outreach events
such as the LogicLounge), and he coordinated the Doctoral Program on Logical Methods
in Computer Science at TU Wien (currently educating more than 40 doctoral students)
and a National Research Network on Rigorous Systems Engineering (uniting fifteen
researchers in Austria to address the challenge of building reliable and safe
computer\r\nsystems). With his enthusiasm and commitment, Helmut completely reshaped
the Austrian research landscape in the field of logic and verification in his
few years as a full professor at TU Wien."
article_processing_charge: No
author:
- first_name: Georg
full_name: Gottlob, Georg
last_name: Gottlob
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Georg
full_name: Weißenbacher, Georg
last_name: Weißenbacher
citation:
ama: Gottlob G, Henzinger TA, Weißenbacher G. Preface of the special issue in memoriam
Helmut Veith. Formal Methods in System Design. 2017;51(2):267-269. doi:10.1007/s10703-017-0307-6
apa: Gottlob, G., Henzinger, T. A., & Weißenbacher, G. (2017). Preface of the
special issue in memoriam Helmut Veith. Formal Methods in System Design.
Springer. https://doi.org/10.1007/s10703-017-0307-6
chicago: Gottlob, Georg, Thomas A Henzinger, and Georg Weißenbacher. “Preface of
the Special Issue in Memoriam Helmut Veith.” Formal Methods in System Design.
Springer, 2017. https://doi.org/10.1007/s10703-017-0307-6.
ieee: G. Gottlob, T. A. Henzinger, and G. Weißenbacher, “Preface of the special
issue in memoriam Helmut Veith,” Formal Methods in System Design, vol.
51, no. 2. Springer, pp. 267–269, 2017.
ista: Gottlob G, Henzinger TA, Weißenbacher G. 2017. Preface of the special issue
in memoriam Helmut Veith. Formal Methods in System Design. 51(2), 267–269.
mla: Gottlob, Georg, et al. “Preface of the Special Issue in Memoriam Helmut Veith.”
Formal Methods in System Design, vol. 51, no. 2, Springer, 2017, pp. 267–69,
doi:10.1007/s10703-017-0307-6.
short: G. Gottlob, T.A. Henzinger, G. Weißenbacher, Formal Methods in System Design
51 (2017) 267–269.
date_created: 2018-12-11T11:48:16Z
date_published: 2017-11-14T00:00:00Z
date_updated: 2023-09-27T12:29:29Z
day: '14'
department:
- _id: ToHe
doi: 10.1007/s10703-017-0307-6
external_id:
isi:
- '000415615600001'
intvolume: ' 51'
isi: 1
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 267 - 269
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '6924'
quality_controlled: '1'
status: public
title: Preface of the special issue in memoriam Helmut Veith
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 51
year: '2017'
...
---
_id: '961'
abstract:
- lang: eng
text: Cell-cell contact formation constitutes the first step in the emergence of multicellularity in
evolution, thereby allowing the differentiation of specialized cell types. In metazoan
development, cell-cell contact formation is thought to influence cell fate specification,
and cell fate specification has been implicated in cell-cell contact
formation. However, remarkably little is yet known about whether and how the
interaction and feedback between cell-cell contact formation and cell fate specification
affect development. Here we identify a positive feedback loop between cell-cell contact duration, morphogen signaling and
mesendoderm cell fate specification during zebrafish gastrulation. We show that long
lasting cell-cell contacts enhance the competence of prechordal plate (ppl) progenitor
cells to respond to Nodal signaling, required for proper ppl cell fate specification. We further
show that Nodal signalling romotes ppl cell-cell contact duration, thereby generating an
effective positive feedback loop between ppl cell-cell contact duration and cell fate
specification. Finally, by using a combination of theoretical modeling and experimentation,
we show that this feedback loop determines whether anterior axial mesendoderm cells
become ppl progenitors or, instead, turn into endoderm progenitors. Our findings reveal
that the gene regulatory networks leading to cell fate diversification within the developing
embryo are controlled by the interdependent activities of cell-cell signaling and contact
formation.
acknowledgement: "Many people accompanied me during this trip: I would not have reached
my destination nor \r\nenjoyed the travelling without them. First of all, thanks
to CP. Thanks for making me part of \r\nyour team, always full of diverse, interesting
and incredibly competent people and thanks for \r\nall the good science I witnessed
\ and participated in. It has been a \r\nblast, an incredibly \r\nexciting
\ one! Thanks to JLo, for teaching me how to master my pipettes and
\ showing me \r\nthat science is a lot of fun. Many, many thanks to Gabby for teaching
me basically everything \r\nabout zebrafish and being always there to advice,
\ sugge\r\nst, support...and play fussball! \r\nThank you to Julien, for the
critical eye on things, Pedro, for all the invaluable feedback and \r\nthe amazing
kicker matches, and Keisuke, for showing me the light, and to the three of them
\r\ntogether for all the good laughs we\r\nhad. My start in Vienna would
\ have been a lot more \r\ndifficult without you guys. Also it would not
\ have been possible without Elena and Inês: \r\nthanks for helping setting
\ up this lab and for the dinners in Gugging. Thanks to Martin, for
\r\nhelping me understand \r\nthe physics behind biology. Thanks to Philipp,
\ for the interest and \r\nadvice, and to Michael, for the Viennise take on things.
Thanks to Julia, for putting up with \r\nbeing our technician and becoming a friend
in the process. And now to the newest members \r\nof th\r\ne lab. Thanks to Daniel
for the enthusiasm and the neverending energy and for all your \r\nhelp over the
years: thank you! To Jana, for showing me that one doesn’t give up, no matter \r\nwhat.
\ To Shayan, for being such a motivated student. To Matt, for helping
\ out\r\nwith coding \r\nand for finding punk solutions to data analysis problems.
Thanks to all the members of the \r\nlab, Verena, Hitoshi, Silvia, Conny, Karla,
Nicoletta, Zoltan, Peng, Benoit, Roland, Yuuta and \r\nFeyza, for the wonderful
\ atmosphere in the lab. Many than\r\nks to Koni and Deborah: doing \r\nexperiments
would have been much more difficult without your help. Special thanks to Katjia
\r\nfor setting up an amazing imaging facility and for building the best
\ team, Robert, Nasser, \r\nAnna and Doreen: thank you for putting up w\r\nith
all the late sortings and for helping with all \r\nthe technical problems. Thanks
to Eva, Verena and Matthias for keeping the fish happy. Big \r\nthanks to Harald
Janovjak for being a present and helpful committee member over the years \r\nand
\ to Patrick Lemaire f\r\nor the helpful insight and extremely interesting
\ discussion we had \r\nabout the project. Also, this journey would not
\ have been the same without all the friends \r\nthat I met in Dresden and
then in Vienna: Daniele, Claire, Kuba, Steffi, Harold, Dejan, Irene, \r\nFab\r\nienne,
Hande, Tiago, Marianne, Jon, Srdjan, Branca, Uli, Murat, Alex, Conny, Christoph,
\r\nCaro, Simone, Barbara, Felipe, Dama, Jose, Hubert and many others that filled
my days with \r\nfun and support. A special thank to my family, always close even
if they are \r\nkilometers away. \r\nGrazie ai miei fratelli, Nunzio e William,
\ e alla mia mamma, per essermi sempre vicini pur \r\nvivendo a chilometri
di distanza. And, last but not least, thanks to Moritz, for putting up with \r\nthe
crazy life of a scientist, the living apart for\r\nso long, never knowing when things
are going \r\nto happen. Thanks for being a great partner and my number one fan!"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Vanessa
full_name: Barone, Vanessa
id: 419EECCC-F248-11E8-B48F-1D18A9856A87
last_name: Barone
orcid: 0000-0003-2676-3367
citation:
ama: 'Barone V. Cell adhesion and cell fate: An effective feedback loop during zebrafish
gastrulation. 2017. doi:10.15479/AT:ISTA:th_825'
apa: 'Barone, V. (2017). Cell adhesion and cell fate: An effective feedback loop
during zebrafish gastrulation. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:th_825'
chicago: 'Barone, Vanessa. “Cell Adhesion and Cell Fate: An Effective Feedback Loop
during Zebrafish Gastrulation.” Institute of Science and Technology Austria, 2017.
https://doi.org/10.15479/AT:ISTA:th_825.'
ieee: 'V. Barone, “Cell adhesion and cell fate: An effective feedback loop during
zebrafish gastrulation,” Institute of Science and Technology Austria, 2017.'
ista: 'Barone V. 2017. Cell adhesion and cell fate: An effective feedback loop during
zebrafish gastrulation. Institute of Science and Technology Austria.'
mla: 'Barone, Vanessa. Cell Adhesion and Cell Fate: An Effective Feedback Loop
during Zebrafish Gastrulation. Institute of Science and Technology Austria,
2017, doi:10.15479/AT:ISTA:th_825.'
short: 'V. Barone, Cell Adhesion and Cell Fate: An Effective Feedback Loop during
Zebrafish Gastrulation, Institute of Science and Technology Austria, 2017.'
date_created: 2018-12-11T11:49:25Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2023-09-27T14:16:45Z
day: '01'
ddc:
- '570'
- '590'
degree_awarded: PhD
department:
- _id: CaHe
doi: 10.15479/AT:ISTA:th_825
file:
- access_level: closed
checksum: 242f88c87f2cf267bf05049fa26a687b
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-04-05T08:36:52Z
date_updated: 2020-07-14T12:48:16Z
file_id: '6205'
file_name: 2017_Barone_thesis_final.docx
file_size: 14497822
relation: source_file
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checksum: ba5b0613ed8bade73a409acdd880fb8a
content_type: application/pdf
creator: dernst
date_created: 2019-04-05T08:36:52Z
date_updated: 2020-07-14T12:48:16Z
file_id: '6206'
file_name: 2017_Barone_thesis_.pdf
file_size: 14995941
relation: main_file
file_date_updated: 2020-07-14T12:48:16Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '109'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6444'
pubrep_id: '825'
related_material:
record:
- id: '1100'
relation: part_of_dissertation
status: public
- id: '1537'
relation: part_of_dissertation
status: public
- id: '1912'
relation: part_of_dissertation
status: public
- id: '2926'
relation: part_of_dissertation
status: public
- id: '3246'
relation: part_of_dissertation
status: public
- id: '676'
relation: part_of_dissertation
status: public
- id: '735'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: 'Cell adhesion and cell fate: An effective feedback loop during zebrafish gastrulation'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2017'
...
---
_id: '734'
abstract:
- lang: eng
text: 'Social insect societies are long-standing models for understanding social
behaviour and evolution. Unlike other advanced biological societies (such as the
multicellular body), the component parts of social insect societies can be easily
deconstructed and manipulated. Recent methodological and theoretical innovations
have exploited this trait to address an expanded range of biological questions.
We illustrate the broadening range of biological insight coming from social insect
biology with four examples. These new frontiers promote open-minded, interdisciplinary
exploration of one of the richest and most complex of biological phenomena: sociality.'
article_processing_charge: No
article_type: original
author:
- first_name: Patrick
full_name: Kennedy, Patrick
last_name: Kennedy
- first_name: Gemma
full_name: Baron, Gemma
last_name: Baron
- first_name: Bitao
full_name: Qiu, Bitao
last_name: Qiu
- first_name: Dalial
full_name: Freitak, Dalial
last_name: Freitak
- first_name: Heikki
full_name: Helantera, Heikki
last_name: Helantera
- first_name: Edmund
full_name: Hunt, Edmund
last_name: Hunt
- first_name: Fabio
full_name: Manfredini, Fabio
last_name: Manfredini
- first_name: Thomas
full_name: O'Shea Wheller, Thomas
last_name: O'Shea Wheller
- first_name: Solenn
full_name: Patalano, Solenn
last_name: Patalano
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Takao
full_name: Sasaki, Takao
last_name: Sasaki
- first_name: Daisy
full_name: Taylor, Daisy
last_name: Taylor
- first_name: Christopher
full_name: Wyatt, Christopher
last_name: Wyatt
- first_name: Seirian
full_name: Sumner, Seirian
last_name: Sumner
citation:
ama: Kennedy P, Baron G, Qiu B, et al. Deconstructing superorganisms and societies
to address big questions in biology. Trends in Ecology and Evolution. 2017;32(11):861-872.
doi:10.1016/j.tree.2017.08.004
apa: Kennedy, P., Baron, G., Qiu, B., Freitak, D., Helantera, H., Hunt, E., … Sumner,
S. (2017). Deconstructing superorganisms and societies to address big questions
in biology. Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/j.tree.2017.08.004
chicago: Kennedy, Patrick, Gemma Baron, Bitao Qiu, Dalial Freitak, Heikki Helantera,
Edmund Hunt, Fabio Manfredini, et al. “Deconstructing Superorganisms and Societies
to Address Big Questions in Biology.” Trends in Ecology and Evolution.
Cell Press, 2017. https://doi.org/10.1016/j.tree.2017.08.004.
ieee: P. Kennedy et al., “Deconstructing superorganisms and societies to
address big questions in biology,” Trends in Ecology and Evolution, vol.
32, no. 11. Cell Press, pp. 861–872, 2017.
ista: Kennedy P, Baron G, Qiu B, Freitak D, Helantera H, Hunt E, Manfredini F, O’Shea
Wheller T, Patalano S, Pull C, Sasaki T, Taylor D, Wyatt C, Sumner S. 2017. Deconstructing
superorganisms and societies to address big questions in biology. Trends in Ecology
and Evolution. 32(11), 861–872.
mla: Kennedy, Patrick, et al. “Deconstructing Superorganisms and Societies to Address
Big Questions in Biology.” Trends in Ecology and Evolution, vol. 32, no.
11, Cell Press, 2017, pp. 861–72, doi:10.1016/j.tree.2017.08.004.
short: P. Kennedy, G. Baron, B. Qiu, D. Freitak, H. Helantera, E. Hunt, F. Manfredini,
T. O’Shea Wheller, S. Patalano, C. Pull, T. Sasaki, D. Taylor, C. Wyatt, S. Sumner,
Trends in Ecology and Evolution 32 (2017) 861–872.
date_created: 2018-12-11T11:48:13Z
date_published: 2017-11-01T00:00:00Z
date_updated: 2023-09-27T14:15:15Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1016/j.tree.2017.08.004
external_id:
isi:
- '000413231900011'
file:
- access_level: open_access
checksum: c8f49309ed9436201814fa7153d66a99
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T16:22:27Z
date_updated: 2020-07-14T12:47:56Z
file_id: '7842'
file_name: 2017_TrendsEcology_Kennedy.pdf
file_size: 15018382
relation: main_file
file_date_updated: 2020-07-14T12:47:56Z
has_accepted_license: '1'
intvolume: ' 32'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 861 - 872
publication: Trends in Ecology and Evolution
publication_identifier:
issn:
- '01695347'
publication_status: published
publisher: Cell Press
publist_id: '6933'
quality_controlled: '1'
related_material:
record:
- id: '819'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Deconstructing superorganisms and societies to address big questions in biology
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2017'
...
---
_id: '819'
abstract:
- lang: eng
text: 'Contagious diseases must transmit from infectious to susceptible hosts in
order to reproduce. Whilst vectored pathogens can rely on intermediaries to find
new hosts for them, many infectious pathogens require close contact or direct
interaction between hosts for transmission. Hence, this means that conspecifics
are often the main source of infection for most animals and so, in theory, animals
should avoid conspecifics to reduce their risk of infection. Of course, in reality
animals must interact with one another, as a bare minimum, to mate. However, being
social provides many additional benefits and group living has become a taxonomically
diverse and widespread trait. How then do social animals overcome the issue of
increased disease? Over the last few decades, the social insects (ants, termites
and some bees and wasps) have become a model system for studying disease in social
animals. On paper, a social insect colony should be particularly susceptible to
disease, given that they often contain thousands of potential hosts that are closely
related and frequently interact, as well as exhibiting stable environmental conditions
that encourage microbial growth. Yet, disease outbreaks appear to be rare and
attempts to eradicate pest species using pathogens have failed time and again.
Evolutionary biologists investigating this observation have discovered that the
reduced disease susceptibility in social insects is, in part, due to collectively
performed disease defences of the workers. These defences act like a “social immune
system” for the colony, resulting in a per capita decrease in disease, termed
social immunity. Our understanding of social immunity, and its importance in relation
to the immunological defences of each insect, continues to grow, but there remain
many open questions. In this thesis I have studied disease defence in garden ants.
In the first data chapter, I use the invasive garden ant, Lasius neglectus, to
investigate how colonies mitigate lethal infections and prevent them from spreading
systemically. I find that ants have evolved ‘destructive disinfection’ – a behaviour
that uses endogenously produced acidic poison to kill diseased brood and to prevent
the pathogen from replicating. In the second experimental chapter, I continue
to study the use of poison in invasive garden ant colonies, finding that it is
sprayed prophylactically within the nest. However, this spraying has negative
effects on developing pupae when they have had their cocoons artificially removed.
Hence, I suggest that acidic nest sanitation may be maintaining larval cocoon
spinning in this species. In the next experimental chapter, I investigated how
colony founding black garden ant queens (Lasius niger) prevent disease when a
co-foundress dies. I show that ant queens prophylactically perform undertaking
behaviours, similar to those performed by the workers in mature nests. When a
co-foundress was infected, these undertaking behaviours improved the survival
of the healthy queen. In the final data chapter, I explored how immunocompetence
(measured as antifungal activity) changes as incipient black garden ant colonies
grow and mature, from the solitary queen phase to colonies with several hundred
workers. Queen and worker antifungal activity varied throughout this time period,
but despite social immunity, did not decrease as colonies matured. In addition
to the above data chapters, this thesis includes two co-authored reviews. In the
first, we examine the state of the art in the field of social immunity and how
it might develop in the future. In the second, we identify several challenges
and open questions in the study of disease defence in animals. We highlight how
social insects offer a unique model to tackle some of these problems, as disease
defence can be studied from the cell to the society. '
acknowledgement: "ERC FP7 programme (grant agreement no. 240371)\r\nI have been supremely
spoilt to work in a lab with such good resources and I must thank the wonderful
Cremer group technicians, Anna, Barbara, Eva and Florian, for all of their help
and keeping the lab up and running. You guys will probably be the most missed once
I realise just how much work you have been saving me! For the same reason, I must
say a big Dzi ę kuj ę Ci to Wonder Woman Wanda, for her tireless efforts feeding
my colonies and cranking out thousands of petri dishes and sugar tubes. Again, you
will be sorely missed now that I will have to take this task on myself. Of course,
I will be eternally indebted to Prof. Sylvia Cremer for taking me under her wing
and being a constant source of guidance and inspiration. You have given me the perfect
balance of independence and supervision. I cannot thank you enough for creating
such a great working environment and allowing me the freedom to follow my own research
questions. I have had so many exceptional opportunities – attending and presenting
at conferences all over the world, inviting me to write the ARE with you, going
to workshops in Panama and Switzerland, and even organising our own PhD course –
that I often think I must have had the best PhD in the world. You have taught me
so much and made me a scientist. I sincerely hope we get the chance to work together
again in the future. Thank you for everything. I must also thank my PhD Committee,
Daria Siekhaus and Jacobus “Koos” Boomsma, for being very supportive throughout
the duration of my PhD. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
citation:
ama: Pull C. Disease defence in garden ants. 2017. doi:10.15479/AT:ISTA:th_861
apa: Pull, C. (2017). Disease defence in garden ants. Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_861
chicago: Pull, Christopher. “Disease Defence in Garden Ants.” Institute of Science
and Technology Austria, 2017. https://doi.org/10.15479/AT:ISTA:th_861.
ieee: C. Pull, “Disease defence in garden ants,” Institute of Science and Technology
Austria, 2017.
ista: Pull C. 2017. Disease defence in garden ants. Institute of Science and Technology
Austria.
mla: Pull, Christopher. Disease Defence in Garden Ants. Institute of Science
and Technology Austria, 2017, doi:10.15479/AT:ISTA:th_861.
short: C. Pull, Disease Defence in Garden Ants, Institute of Science and Technology
Austria, 2017.
date_created: 2018-12-11T11:48:40Z
date_published: 2017-09-26T00:00:00Z
date_updated: 2023-09-28T11:31:32Z
day: '26'
ddc:
- '576'
- '577'
- '578'
- '579'
- '590'
- '592'
degree_awarded: PhD
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:th_861
file:
- access_level: closed
checksum: 4993cdd5382295758ecc3ecbd2a9aaff
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-04-05T07:53:04Z
date_updated: 2020-07-14T12:48:09Z
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file_name: 2017_Thesis_Pull.docx
file_size: 18580400
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checksum: ee2e3ebb5b53c154c866f5b052b25153
content_type: application/pdf
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date_created: 2019-04-05T07:53:04Z
date_updated: 2020-07-14T12:48:09Z
file_id: '6200'
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file_date_updated: 2020-07-14T12:48:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '122'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6830'
pubrep_id: '861'
related_material:
record:
- id: '616'
relation: part_of_dissertation
status: public
- id: '806'
relation: part_of_dissertation
status: public
- id: '734'
relation: part_of_dissertation
status: public
- id: '732'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Sylvia M
full_name: Cremer, Sylvia M
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Disease defence in garden ants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2017'
...
---
_id: '732'
abstract:
- lang: eng
text: 'Background: Social insects form densely crowded societies in environments
with high pathogen loads, but have evolved collective defences that mitigate the
impact of disease. However, colony-founding queens lack this protection and suffer
high rates of mortality. The impact of pathogens may be exacerbated in species
where queens found colonies together, as healthy individuals may contract pathogens
from infectious co-founders. Therefore, we tested whether ant queens avoid founding
colonies with pathogen-exposed conspecifics and how they might limit disease transmission
from infectious individuals. Results: Using Lasius Niger queens and a naturally
infecting fungal pathogen Metarhizium brunneum, we observed that queens were equally
likely to found colonies with another pathogen-exposed or sham-treated queen.
However, when one queen died, the surviving individual performed biting, burial
and removal of the corpse. These undertaking behaviours were performed prophylactically,
i.e. targeted equally towards non-infected and infected corpses, as well as carried
out before infected corpses became infectious. Biting and burial reduced the risk
of the queens contracting and dying from disease from an infectious corpse of
a dead co-foundress. Conclusions: We show that co-founding ant queens express
undertaking behaviours that, in mature colonies, are performed exclusively by
workers. Such infection avoidance behaviours act before the queens can contract
the disease and will therefore improve the overall chance of colony founding success
in ant queens.'
article_number: '219'
article_processing_charge: Yes
article_type: original
author:
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Pull C, Cremer S. Co-founding ant queens prevent disease by performing prophylactic
undertaking behaviour. BMC Evolutionary Biology. 2017;17(1). doi:10.1186/s12862-017-1062-4
apa: Pull, C., & Cremer, S. (2017). Co-founding ant queens prevent disease by
performing prophylactic undertaking behaviour. BMC Evolutionary Biology.
BioMed Central. https://doi.org/10.1186/s12862-017-1062-4
chicago: Pull, Christopher, and Sylvia Cremer. “Co-Founding Ant Queens Prevent Disease
by Performing Prophylactic Undertaking Behaviour.” BMC Evolutionary Biology.
BioMed Central, 2017. https://doi.org/10.1186/s12862-017-1062-4.
ieee: C. Pull and S. Cremer, “Co-founding ant queens prevent disease by performing
prophylactic undertaking behaviour,” BMC Evolutionary Biology, vol. 17,
no. 1. BioMed Central, 2017.
ista: Pull C, Cremer S. 2017. Co-founding ant queens prevent disease by performing
prophylactic undertaking behaviour. BMC Evolutionary Biology. 17(1), 219.
mla: Pull, Christopher, and Sylvia Cremer. “Co-Founding Ant Queens Prevent Disease
by Performing Prophylactic Undertaking Behaviour.” BMC Evolutionary Biology,
vol. 17, no. 1, 219, BioMed Central, 2017, doi:10.1186/s12862-017-1062-4.
short: C. Pull, S. Cremer, BMC Evolutionary Biology 17 (2017).
date_created: 2018-12-11T11:48:12Z
date_published: 2017-10-13T00:00:00Z
date_updated: 2023-09-28T11:31:32Z
day: '13'
ddc:
- '576'
- '592'
department:
- _id: SyCr
doi: 10.1186/s12862-017-1062-4
ec_funded: 1
external_id:
isi:
- '000412816800001'
file:
- access_level: open_access
checksum: 3e24a2cfd48f49f7b3643d08d30fb480
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:18Z
date_updated: 2020-07-14T12:47:55Z
file_id: '5271'
file_name: IST-2017-882-v1+1_12862_2017_Article_1062.pdf
file_size: 949857
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25DC711C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '243071'
name: 'Social Vaccination in Ant Colonies: from Individual Mechanisms to Society
Effects'
publication: BMC Evolutionary Biology
publication_identifier:
issn:
- '14712148'
publication_status: published
publisher: BioMed Central
publist_id: '6937'
pubrep_id: '882'
quality_controlled: '1'
related_material:
record:
- id: '819'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Co-founding ant queens prevent disease by performing prophylactic undertaking
behaviour
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 17
year: '2017'
...
---
_id: '726'
abstract:
- lang: eng
text: The morphogenesis of branched organs remains a subject of abiding interest.
Although much is known about the underlying signaling pathways, it remains unclear
how macroscopic features of branched organs, including their size, network topology,
and spatial patterning, are encoded. Here, we show that, in mouse mammary gland,
kidney, and human prostate, these features can be explained quantitatively within
a single unifying framework of branching and annihilating random walks. Based
on quantitative analyses of large-scale organ reconstructions and proliferation
kinetics measurements, we propose that morphogenesis follows from the proliferative
activity of equipotent tips that stochastically branch and randomly explore their
environment but compete neutrally for space, becoming proliferatively inactive
when in proximity with neighboring ducts. These results show that complex branched
epithelial structures develop as a self-organized process, reliant upon a strikingly
simple but generic rule, without recourse to a rigid and deterministic sequence
of genetically programmed events.
article_processing_charge: No
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Colinda
full_name: Scheele, Colinda
last_name: Scheele
- first_name: Mohammad
full_name: Moad, Mohammad
last_name: Moad
- first_name: Nicholas
full_name: Drogo, Nicholas
last_name: Drogo
- first_name: Rakesh
full_name: Heer, Rakesh
last_name: Heer
- first_name: Rosemary
full_name: Sampogna, Rosemary
last_name: Sampogna
- first_name: Jacco
full_name: Van Rheenen, Jacco
last_name: Van Rheenen
- first_name: Benjamin
full_name: Simons, Benjamin
last_name: Simons
citation:
ama: Hannezo EB, Scheele C, Moad M, et al. A unifying theory of branching morphogenesis.
Cell. 2017;171(1):242-255. doi:10.1016/j.cell.2017.08.026
apa: Hannezo, E. B., Scheele, C., Moad, M., Drogo, N., Heer, R., Sampogna, R., …
Simons, B. (2017). A unifying theory of branching morphogenesis. Cell.
Cell Press. https://doi.org/10.1016/j.cell.2017.08.026
chicago: Hannezo, Edouard B, Colinda Scheele, Mohammad Moad, Nicholas Drogo, Rakesh
Heer, Rosemary Sampogna, Jacco Van Rheenen, and Benjamin Simons. “A Unifying Theory
of Branching Morphogenesis.” Cell. Cell Press, 2017. https://doi.org/10.1016/j.cell.2017.08.026.
ieee: E. B. Hannezo et al., “A unifying theory of branching morphogenesis,”
Cell, vol. 171, no. 1. Cell Press, pp. 242–255, 2017.
ista: Hannezo EB, Scheele C, Moad M, Drogo N, Heer R, Sampogna R, Van Rheenen J,
Simons B. 2017. A unifying theory of branching morphogenesis. Cell. 171(1), 242–255.
mla: Hannezo, Edouard B., et al. “A Unifying Theory of Branching Morphogenesis.”
Cell, vol. 171, no. 1, Cell Press, 2017, pp. 242–55, doi:10.1016/j.cell.2017.08.026.
short: E.B. Hannezo, C. Scheele, M. Moad, N. Drogo, R. Heer, R. Sampogna, J. Van
Rheenen, B. Simons, Cell 171 (2017) 242–255.
date_created: 2018-12-11T11:48:10Z
date_published: 2017-09-21T00:00:00Z
date_updated: 2023-09-28T11:34:17Z
day: '21'
ddc:
- '539'
department:
- _id: EdHa
doi: 10.1016/j.cell.2017.08.026
external_id:
isi:
- '000411331800024'
file:
- access_level: open_access
checksum: 7a036d93a9e2e597af9bb504d6133aca
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:17Z
date_updated: 2020-07-14T12:47:55Z
file_id: '4870'
file_name: IST-2017-883-v1+1_PIIS0092867417309510.pdf
file_size: 12670204
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 171'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 242 - 255
publication: Cell
publication_identifier:
issn:
- '00928674'
publication_status: published
publisher: Cell Press
publist_id: '6952'
pubrep_id: '883'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A unifying theory of branching morphogenesis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 171
year: '2017'
...
---
_id: '727'
abstract:
- lang: eng
text: 'Actin filaments polymerizing against membranes power endocytosis, vesicular
traffic, and cell motility. In vitro reconstitution studies suggest that the structure
and the dynamics of actin networks respond to mechanical forces. We demonstrate
that lamellipodial actin of migrating cells responds to mechanical load when membrane
tension is modulated. In a steady state, migrating cell filaments assume the canonical
dendritic geometry, defined by Arp2/3-generated 70° branch points. Increased tension
triggers a dense network with a broadened range of angles, whereas decreased tension
causes a shift to a sparse configuration dominated by filaments growing perpendicularly
to the plasma membrane. We show that these responses emerge from the geometry
of branched actin: when load per filament decreases, elongation speed increases
and perpendicular filaments gradually outcompete others because they polymerize
the shortest distance to the membrane, where they are protected from capping.
This network-intrinsic geometrical adaptation mechanism tunes protrusive force
in response to mechanical load.'
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Jan
full_name: Mueller, Jan
last_name: Mueller
- first_name: Gregory
full_name: Szep, Gregory
id: 4BFB7762-F248-11E8-B48F-1D18A9856A87
last_name: Szep
- first_name: Maria
full_name: Nemethova, Maria
id: 34E27F1C-F248-11E8-B48F-1D18A9856A87
last_name: Nemethova
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Arnon
full_name: Lieber, Arnon
last_name: Lieber
- first_name: Christoph
full_name: Winkler, Christoph
last_name: Winkler
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: John
full_name: Small, John
last_name: Small
- first_name: Christian
full_name: Schmeiser, Christian
last_name: Schmeiser
- first_name: Kinneret
full_name: Keren, Kinneret
last_name: Keren
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Mueller J, Szep G, Nemethova M, et al. Load adaptation of lamellipodial actin
networks. Cell. 2017;171(1):188-200. doi:10.1016/j.cell.2017.07.051
apa: Mueller, J., Szep, G., Nemethova, M., de Vries, I., Lieber, A., Winkler, C.,
… Sixt, M. K. (2017). Load adaptation of lamellipodial actin networks. Cell.
Cell Press. https://doi.org/10.1016/j.cell.2017.07.051
chicago: Mueller, Jan, Gregory Szep, Maria Nemethova, Ingrid de Vries, Arnon Lieber,
Christoph Winkler, Karsten Kruse, et al. “Load Adaptation of Lamellipodial Actin
Networks.” Cell. Cell Press, 2017. https://doi.org/10.1016/j.cell.2017.07.051.
ieee: J. Mueller et al., “Load adaptation of lamellipodial actin networks,”
Cell, vol. 171, no. 1. Cell Press, pp. 188–200, 2017.
ista: Mueller J, Szep G, Nemethova M, de Vries I, Lieber A, Winkler C, Kruse K,
Small J, Schmeiser C, Keren K, Hauschild R, Sixt MK. 2017. Load adaptation of
lamellipodial actin networks. Cell. 171(1), 188–200.
mla: Mueller, Jan, et al. “Load Adaptation of Lamellipodial Actin Networks.” Cell,
vol. 171, no. 1, Cell Press, 2017, pp. 188–200, doi:10.1016/j.cell.2017.07.051.
short: J. Mueller, G. Szep, M. Nemethova, I. de Vries, A. Lieber, C. Winkler, K.
Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017)
188–200.
date_created: 2018-12-11T11:48:10Z
date_published: 2017-09-21T00:00:00Z
date_updated: 2023-09-28T11:33:49Z
day: '21'
department:
- _id: MiSi
- _id: Bio
doi: 10.1016/j.cell.2017.07.051
ec_funded: 1
external_id:
isi:
- '000411331800020'
intvolume: ' 171'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa_version: None
page: 188 - 200
project:
- _id: 25AD6156-B435-11E9-9278-68D0E5697425
grant_number: LS13-029
name: Modeling of Polarization and Motility of Leukocytes in Three-Dimensional Environments
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
publication: Cell
publication_identifier:
issn:
- '00928674'
publication_status: published
publisher: Cell Press
publist_id: '6951'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Load adaptation of lamellipodial actin networks
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 171
year: '2017'
...
---
_id: '730'
abstract:
- lang: eng
text: Neural responses are highly structured, with population activity restricted
to a small subset of the astronomical range of possible activity patterns. Characterizing
these statistical regularities is important for understanding circuit computation,
but challenging in practice. Here we review recent approaches based on the maximum
entropy principle used for quantifying collective behavior in neural activity.
We highlight recent models that capture population-level statistics of neural
data, yielding insights into the organization of the neural code and its biological
substrate. Furthermore, the MaxEnt framework provides a general recipe for constructing
surrogate ensembles that preserve aspects of the data, but are otherwise maximally
unstructured. This idea can be used to generate a hierarchy of controls against
which rigorous statistical tests are possible.
article_processing_charge: No
author:
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
citation:
ama: Savin C, Tkačik G. Maximum entropy models as a tool for building precise neural
controls. Current Opinion in Neurobiology. 2017;46:120-126. doi:10.1016/j.conb.2017.08.001
apa: Savin, C., & Tkačik, G. (2017). Maximum entropy models as a tool for building
precise neural controls. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2017.08.001
chicago: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for
Building Precise Neural Controls.” Current Opinion in Neurobiology. Elsevier,
2017. https://doi.org/10.1016/j.conb.2017.08.001.
ieee: C. Savin and G. Tkačik, “Maximum entropy models as a tool for building precise
neural controls,” Current Opinion in Neurobiology, vol. 46. Elsevier, pp.
120–126, 2017.
ista: Savin C, Tkačik G. 2017. Maximum entropy models as a tool for building precise
neural controls. Current Opinion in Neurobiology. 46, 120–126.
mla: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for Building
Precise Neural Controls.” Current Opinion in Neurobiology, vol. 46, Elsevier,
2017, pp. 120–26, doi:10.1016/j.conb.2017.08.001.
short: C. Savin, G. Tkačik, Current Opinion in Neurobiology 46 (2017) 120–126.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2023-09-28T11:32:22Z
day: '01'
department:
- _id: GaTk
doi: 10.1016/j.conb.2017.08.001
ec_funded: 1
external_id:
isi:
- '000416196400016'
intvolume: ' 46'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 120 - 126
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- '09594388'
publication_status: published
publisher: Elsevier
publist_id: '6943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maximum entropy models as a tool for building precise neural controls
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 46
year: '2017'
...
---
_id: '728'
abstract:
- lang: eng
text: During animal development, cell-fate-specific changes in gene expression can
modify the material properties of a tissue and drive tissue morphogenesis. While
mechanistic insights into the genetic control of tissue-shaping events are beginning
to emerge, how tissue morphogenesis and mechanics can reciprocally impact cell-fate
specification remains relatively unexplored. Here we review recent findings reporting
how multicellular morphogenetic events and their underlying mechanical forces
can feed back into gene regulatory pathways to specify cell fate. We further discuss
emerging techniques that allow for the direct measurement and manipulation of
mechanical signals in vivo, offering unprecedented access to study mechanotransduction
during development. Examination of the mechanical control of cell fate during
tissue morphogenesis will pave the way to an integrated understanding of the design
principles that underlie robust tissue patterning in embryonic development.
article_processing_charge: No
author:
- first_name: Chii
full_name: Chan, Chii
last_name: Chan
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Takashi
full_name: Hiiragi, Takashi
last_name: Hiiragi
citation:
ama: Chan C, Heisenberg C-PJ, Hiiragi T. Coordination of morphogenesis and cell
fate specification in development. Current Biology. 2017;27(18):R1024-R1035.
doi:10.1016/j.cub.2017.07.010
apa: Chan, C., Heisenberg, C.-P. J., & Hiiragi, T. (2017). Coordination of morphogenesis
and cell fate specification in development. Current Biology. Cell Press.
https://doi.org/10.1016/j.cub.2017.07.010
chicago: Chan, Chii, Carl-Philipp J Heisenberg, and Takashi Hiiragi. “Coordination
of Morphogenesis and Cell Fate Specification in Development.” Current Biology.
Cell Press, 2017. https://doi.org/10.1016/j.cub.2017.07.010.
ieee: C. Chan, C.-P. J. Heisenberg, and T. Hiiragi, “Coordination of morphogenesis
and cell fate specification in development,” Current Biology, vol. 27,
no. 18. Cell Press, pp. R1024–R1035, 2017.
ista: Chan C, Heisenberg C-PJ, Hiiragi T. 2017. Coordination of morphogenesis and
cell fate specification in development. Current Biology. 27(18), R1024–R1035.
mla: Chan, Chii, et al. “Coordination of Morphogenesis and Cell Fate Specification
in Development.” Current Biology, vol. 27, no. 18, Cell Press, 2017, pp.
R1024–35, doi:10.1016/j.cub.2017.07.010.
short: C. Chan, C.-P.J. Heisenberg, T. Hiiragi, Current Biology 27 (2017) R1024–R1035.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-09-18T00:00:00Z
date_updated: 2023-09-28T11:33:21Z
day: '18'
department:
- _id: CaHe
doi: 10.1016/j.cub.2017.07.010
external_id:
isi:
- '000411581800019'
intvolume: ' 27'
isi: 1
issue: '18'
language:
- iso: eng
month: '09'
oa_version: None
page: R1024 - R1035
publication: Current Biology
publication_identifier:
issn:
- '09609822'
publication_status: published
publisher: Cell Press
publist_id: '6949'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coordination of morphogenesis and cell fate specification in development
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 27
year: '2017'
...
---
_id: '729'
abstract:
- lang: eng
text: The cellular mechanisms allowing tissues to efficiently regenerate are not
fully understood. In this issue of Developmental Cell, Cao et al. (2017)) discover
that during zebrafish heart regeneration, epicardial cells at the leading edge
of regenerating tissue undergo endoreplication, possibly due to increased tissue
tension, thereby boosting their regenerative capacity.
article_processing_charge: No
author:
- first_name: Zoltan P
full_name: Spiro, Zoltan P
id: 426AD026-F248-11E8-B48F-1D18A9856A87
last_name: Spiro
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Spiro ZP, Heisenberg C-PJ. Regeneration tensed up polyploidy takes the lead.
Developmental Cell. 2017;42(6):559-560. doi:10.1016/j.devcel.2017.09.008
apa: Spiro, Z. P., & Heisenberg, C.-P. J. (2017). Regeneration tensed up polyploidy
takes the lead. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2017.09.008
chicago: Spiro, Zoltan P, and Carl-Philipp J Heisenberg. “Regeneration Tensed up
Polyploidy Takes the Lead.” Developmental Cell. Cell Press, 2017. https://doi.org/10.1016/j.devcel.2017.09.008.
ieee: Z. P. Spiro and C.-P. J. Heisenberg, “Regeneration tensed up polyploidy takes
the lead,” Developmental Cell, vol. 42, no. 6. Cell Press, pp. 559–560,
2017.
ista: Spiro ZP, Heisenberg C-PJ. 2017. Regeneration tensed up polyploidy takes the
lead. Developmental Cell. 42(6), 559–560.
mla: Spiro, Zoltan P., and Carl-Philipp J. Heisenberg. “Regeneration Tensed up Polyploidy
Takes the Lead.” Developmental Cell, vol. 42, no. 6, Cell Press, 2017,
pp. 559–60, doi:10.1016/j.devcel.2017.09.008.
short: Z.P. Spiro, C.-P.J. Heisenberg, Developmental Cell 42 (2017) 559–560.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-09-28T11:32:49Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2017.09.008
external_id:
isi:
- '000411582800003'
intvolume: ' 42'
isi: 1
issue: '6'
language:
- iso: eng
month: '01'
oa_version: None
page: 559 - 560
publication: Developmental Cell
publication_identifier:
issn:
- '15345807'
publication_status: published
publisher: Cell Press
publist_id: '6948'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regeneration tensed up polyploidy takes the lead
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 42
year: '2017'
...
---
_id: '548'
abstract:
- lang: eng
text: In this work maximum entropy distributions in the space of steady states of
metabolic networks are considered upon constraining the first and second moments
of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux
distributions, emerges upon considering control on the average growth (optimization)
and its fluctuations (heterogeneity). This is applied to the carbon catabolic
core of Escherichia coli where it quantifies the metabolic activity of slow growing
phenotypes and it provides a quantitative map with metabolic fluxes, opening the
possibility to detect coexistence from flux data. A preliminary analysis on data
for E. coli cultures in standard conditions shows degeneracy for the inferred
parameters that extend in the coexistence region.
alternative_title:
- Rapid Communications
article_number: '060401'
article_processing_charge: No
author:
- first_name: Daniele
full_name: De Martino, Daniele
id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
last_name: De Martino
orcid: 0000-0002-5214-4706
citation:
ama: De Martino D. Maximum entropy modeling of metabolic networks by constraining
growth-rate moments predicts coexistence of phenotypes. Physical Review E.
2017;96(6). doi:10.1103/PhysRevE.96.060401
apa: De Martino, D. (2017). Maximum entropy modeling of metabolic networks by constraining
growth-rate moments predicts coexistence of phenotypes. Physical Review E.
American Physical Society. https://doi.org/10.1103/PhysRevE.96.060401
chicago: De Martino, Daniele. “Maximum Entropy Modeling of Metabolic Networks by
Constraining Growth-Rate Moments Predicts Coexistence of Phenotypes.” Physical
Review E. American Physical Society, 2017. https://doi.org/10.1103/PhysRevE.96.060401.
ieee: D. De Martino, “Maximum entropy modeling of metabolic networks by constraining
growth-rate moments predicts coexistence of phenotypes,” Physical Review E,
vol. 96, no. 6. American Physical Society, 2017.
ista: De Martino D. 2017. Maximum entropy modeling of metabolic networks by constraining
growth-rate moments predicts coexistence of phenotypes. Physical Review E. 96(6),
060401.
mla: De Martino, Daniele. “Maximum Entropy Modeling of Metabolic Networks by Constraining
Growth-Rate Moments Predicts Coexistence of Phenotypes.” Physical Review E,
vol. 96, no. 6, 060401, American Physical Society, 2017, doi:10.1103/PhysRevE.96.060401.
short: D. De Martino, Physical Review E 96 (2017).
date_created: 2018-12-11T11:47:06Z
date_published: 2017-12-21T00:00:00Z
date_updated: 2023-10-10T13:29:38Z
day: '21'
department:
- _id: GaTk
doi: 10.1103/PhysRevE.96.060401
ec_funded: 1
intvolume: ' 96'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1707.00320
month: '12'
oa: 1
oa_version: Submitted Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Physical Review E
publication_identifier:
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
publist_id: '7266'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maximum entropy modeling of metabolic networks by constraining growth-rate
moments predicts coexistence of phenotypes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2017'
...
---
_id: '673'
abstract:
- lang: eng
text: We present a numerical study of wavy supercritical cylindrical Couette flow
between counter-rotating cylinders in which the wavy pattern propagates either
prograde with the inner cylinder or retrograde opposite the rotation of the inner
cylinder. The wave propagation reversals from prograde to retrograde and vice
versa occur at distinct values of the inner cylinder Reynolds number when the
associated frequency of the wavy instability vanishes. The reversal occurs for
both twofold and threefold symmetric wavy vortices. Moreover, the wave propagation
reversal only occurs for sufficiently strong counter-rotation. The flow pattern
reversal appears to be intrinsic in the system as either periodic boundary conditions
or fixed end wall boundary conditions for different system sizes always result
in the wave propagation reversal. We present a detailed bifurcation sequence and
parameter space diagram with respect to retrograde behavior of wavy flows. The
retrograde propagation of the instability occurs when the inner Reynolds number
is about two times the outer Reynolds number. The mechanism for the retrograde
propagation is associated with the inviscidly unstable region near the inner cylinder
and the direction of the global average azimuthal velocity. Flow dynamics, spatio-temporal
behavior, global mean angular velocity, and torque of the flow with the wavy pattern
are explored.
article_number: '053103'
article_processing_charge: No
author:
- first_name: Sebastian
full_name: Altmeyer, Sebastian
id: 2EE67FDC-F248-11E8-B48F-1D18A9856A87
last_name: Altmeyer
orcid: 0000-0001-5964-0203
- first_name: Richard
full_name: Lueptow, Richard
last_name: Lueptow
citation:
ama: Altmeyer S, Lueptow R. Wave propagation reversal for wavy vortices in wide
gap counter rotating cylindrical Couette flow. Physical Review E. 2017;95(5).
doi:10.1103/PhysRevE.95.053103
apa: Altmeyer, S., & Lueptow, R. (2017). Wave propagation reversal for wavy
vortices in wide gap counter rotating cylindrical Couette flow. Physical Review
E. American Physical Society. https://doi.org/10.1103/PhysRevE.95.053103
chicago: Altmeyer, Sebastian, and Richard Lueptow. “Wave Propagation Reversal for
Wavy Vortices in Wide Gap Counter Rotating Cylindrical Couette Flow.” Physical
Review E. American Physical Society, 2017. https://doi.org/10.1103/PhysRevE.95.053103.
ieee: S. Altmeyer and R. Lueptow, “Wave propagation reversal for wavy vortices in
wide gap counter rotating cylindrical Couette flow,” Physical Review E,
vol. 95, no. 5. American Physical Society, 2017.
ista: Altmeyer S, Lueptow R. 2017. Wave propagation reversal for wavy vortices in
wide gap counter rotating cylindrical Couette flow. Physical Review E. 95(5),
053103.
mla: Altmeyer, Sebastian, and Richard Lueptow. “Wave Propagation Reversal for Wavy
Vortices in Wide Gap Counter Rotating Cylindrical Couette Flow.” Physical Review
E, vol. 95, no. 5, 053103, American Physical Society, 2017, doi:10.1103/PhysRevE.95.053103.
short: S. Altmeyer, R. Lueptow, Physical Review E 95 (2017).
date_created: 2018-12-11T11:47:50Z
date_published: 2017-05-10T00:00:00Z
date_updated: 2023-10-10T13:30:03Z
day: '10'
department:
- _id: BjHo
doi: 10.1103/PhysRevE.95.053103
intvolume: ' 95'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/pdf/physics/0505164.pdf
month: '05'
oa: 1
oa_version: Submitted Version
publication: Physical Review E
publication_identifier:
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
publist_id: '7049'
scopus_import: '1'
status: public
title: Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical
Couette flow
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 95
year: '2017'
...
---
_id: '447'
abstract:
- lang: eng
text: We consider last passage percolation (LPP) models with exponentially distributed
random variables, which are linked to the totally asymmetric simple exclusion
process (TASEP). The competition interface for LPP was introduced and studied
in Ferrari and Pimentel (2005a) for cases where the corresponding exclusion process
had a rarefaction fan. Here we consider situations with a shock and determine
the law of the fluctuations of the competition interface around its deter- ministic
law of large number position. We also study the multipoint distribution of the
LPP around the shock, extending our one-point result of Ferrari and Nejjar (2015).
article_processing_charge: No
article_type: original
author:
- first_name: Patrik
full_name: Ferrari, Patrik
last_name: Ferrari
- first_name: Peter
full_name: Nejjar, Peter
id: 4BF426E2-F248-11E8-B48F-1D18A9856A87
last_name: Nejjar
citation:
ama: Ferrari P, Nejjar P. Fluctuations of the competition interface in presence
of shocks. Revista Latino-Americana de Probabilidade e Estatística. 2017;9:299-325.
doi:10.30757/ALEA.v14-17
apa: Ferrari, P., & Nejjar, P. (2017). Fluctuations of the competition interface
in presence of shocks. Revista Latino-Americana de Probabilidade e Estatística.
Instituto Nacional de Matematica Pura e Aplicada. https://doi.org/10.30757/ALEA.v14-17
chicago: Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface
in Presence of Shocks.” Revista Latino-Americana de Probabilidade e Estatística.
Instituto Nacional de Matematica Pura e Aplicada, 2017. https://doi.org/10.30757/ALEA.v14-17.
ieee: P. Ferrari and P. Nejjar, “Fluctuations of the competition interface in presence
of shocks,” Revista Latino-Americana de Probabilidade e Estatística, vol.
9. Instituto Nacional de Matematica Pura e Aplicada, pp. 299–325, 2017.
ista: Ferrari P, Nejjar P. 2017. Fluctuations of the competition interface in presence
of shocks. Revista Latino-Americana de Probabilidade e Estatística. 9, 299–325.
mla: Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface
in Presence of Shocks.” Revista Latino-Americana de Probabilidade e Estatística,
vol. 9, Instituto Nacional de Matematica Pura e Aplicada, 2017, pp. 299–325, doi:10.30757/ALEA.v14-17.
short: P. Ferrari, P. Nejjar, Revista Latino-Americana de Probabilidade e Estatística
9 (2017) 299–325.
date_created: 2018-12-11T11:46:31Z
date_published: 2017-03-23T00:00:00Z
date_updated: 2023-10-10T13:10:32Z
day: '23'
department:
- _id: LaEr
- _id: JaMa
doi: 10.30757/ALEA.v14-17
ec_funded: 1
intvolume: ' 9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://alea.impa.br/articles/v14/14-17.pdf
month: '03'
oa: 1
oa_version: Submitted Version
page: 299 - 325
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
publication: Revista Latino-Americana de Probabilidade e Estatística
publication_status: published
publisher: Instituto Nacional de Matematica Pura e Aplicada
publist_id: '7376'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fluctuations of the competition interface in presence of shocks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '557'
abstract:
- lang: eng
text: PURPOSE. Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful
therapeutic for the rescue and regeneration of these cells after optic nerve damage.
However, early after damage, RGCs undergo atrophic changes, including gene silencing.
It is not known if these changes will deleteriously affect transduction and transgene
expression, or if the therapeutic protein can influence reactivation of the endogenous
genome. METHODS. Double-transgenic mice carrying a Rosa26-(LoxP)-tdTomato reporter,
and a mutant allele for the proapoptotic Bax gene were reared. The Bax mutant
blocks apoptosis, but RGCs still exhibit nuclear atrophy and gene silencing. At
times ranging from 1 hour to 4 weeks after optic nerve crush (ONC), eyes received
an intravitreal injection of AAV2 virus carrying the Cre recombinase. Successful
transduction was monitored by expression of the tdTomato reporter. Immunostaining
was used to localize tdTomato expression in select cell types. RESULTS. Successful
transduction of RGCs was achieved at all time points after ONC using AAV2 expressing
Cre from the phosphoglycerate kinase (Pgk) promoter, but not the CMV promoter.
ONC promoted an increase in the transduction of cell types in the inner nuclear
layer, including Müller cells and rod bipolar neurons. There was minimal evidence
of transduction of amacrine cells and astrocytes in the inner retina or optic
nerve. CONCLUSIONS. Damaged RGCs can be transduced and at least some endogenous
genes can be subsequently activated. Optic nerve damage may change retinal architecture
to allow greater penetration of an AAV2 virus to transduce several additional
cell types in the inner nuclear layer.
article_processing_charge: No
author:
- first_name: Robert
full_name: Nickells, Robert
last_name: Nickells
- first_name: Heather
full_name: Schmitt, Heather
last_name: Schmitt
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: Cassandra
full_name: Schlamp, Cassandra
last_name: Schlamp
citation:
ama: Nickells R, Schmitt H, Maes ME, Schlamp C. AAV2 mediated transduction of the
mouse retina after optic nerve injury. Investigative Ophthalmology and Visual
Science. 2017;58(14):6091-6104. doi:10.1167/iovs.17-22634
apa: Nickells, R., Schmitt, H., Maes, M. E., & Schlamp, C. (2017). AAV2 mediated
transduction of the mouse retina after optic nerve injury. Investigative Ophthalmology
and Visual Science. Association for Research in Vision and Ophthalmology.
https://doi.org/10.1167/iovs.17-22634
chicago: Nickells, Robert, Heather Schmitt, Margaret E Maes, and Cassandra Schlamp.
“AAV2 Mediated Transduction of the Mouse Retina after Optic Nerve Injury.” Investigative
Ophthalmology and Visual Science. Association for Research in Vision and Ophthalmology,
2017. https://doi.org/10.1167/iovs.17-22634.
ieee: R. Nickells, H. Schmitt, M. E. Maes, and C. Schlamp, “AAV2 mediated transduction
of the mouse retina after optic nerve injury,” Investigative Ophthalmology
and Visual Science, vol. 58, no. 14. Association for Research in Vision and
Ophthalmology, pp. 6091–6104, 2017.
ista: Nickells R, Schmitt H, Maes ME, Schlamp C. 2017. AAV2 mediated transduction
of the mouse retina after optic nerve injury. Investigative Ophthalmology and
Visual Science. 58(14), 6091–6104.
mla: Nickells, Robert, et al. “AAV2 Mediated Transduction of the Mouse Retina after
Optic Nerve Injury.” Investigative Ophthalmology and Visual Science, vol.
58, no. 14, Association for Research in Vision and Ophthalmology, 2017, pp. 6091–104,
doi:10.1167/iovs.17-22634.
short: R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology
and Visual Science 58 (2017) 6091–6104.
date_created: 2018-12-11T11:47:10Z
date_published: 2017-12-14T00:00:00Z
date_updated: 2023-10-10T14:06:18Z
day: '14'
ddc:
- '576'
department:
- _id: SaSi
doi: 10.1167/iovs.17-22634
file:
- access_level: open_access
checksum: d7a7b6f1fa9211a04e5e65634a0265d9
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:53Z
date_updated: 2020-07-14T12:47:04Z
file_id: '5311'
file_name: IST-2018-920-v1+1_i1552-5783-58-14-6091.pdf
file_size: 2955559
relation: main_file
file_date_updated: 2020-07-14T12:47:04Z
has_accepted_license: '1'
intvolume: ' 58'
issue: '14'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 6091 - 6104
publication: Investigative Ophthalmology and Visual Science
publication_identifier:
issn:
- '01460404'
publication_status: published
publisher: Association for Research in Vision and Ophthalmology
publist_id: '7254'
pubrep_id: '920'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AAV2 mediated transduction of the mouse retina after optic nerve injury
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2017'
...
---
_id: '997'
abstract:
- lang: eng
text: Recently it was shown that molecules rotating in superfluid helium can be
described in terms of the angulon quasiparticles (Phys. Rev. Lett. 118, 095301
(2017)). Here we demonstrate that in the experimentally realized regime the angulon
can be seen as a point charge on a 2-sphere interacting with a gauge field of
a non-abelian magnetic monopole. Unlike in several other settings, the gauge fields
of the angulon problem emerge in the real coordinate space, as opposed to the
momentum space or some effective parameter space. Furthermore, we find a topological
transition associated with making the monopole abelian, which takes place in the
vicinity of the previously reported angulon instabilities. These results pave
the way for studying topological phenomena in experiments on molecules trapped
in superfluid helium nanodroplets, as well as on other realizations of orbital
impurity problems.
article_number: '235301'
article_processing_charge: No
article_type: original
author:
- first_name: Enderalp
full_name: Yakaboylu, Enderalp
id: 38CB71F6-F248-11E8-B48F-1D18A9856A87
last_name: Yakaboylu
orcid: 0000-0001-5973-0874
- first_name: Andreas
full_name: Deuchert, Andreas
id: 4DA65CD0-F248-11E8-B48F-1D18A9856A87
last_name: Deuchert
orcid: 0000-0003-3146-6746
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
citation:
ama: Yakaboylu E, Deuchert A, Lemeshko M. Emergence of non-abelian magnetic monopoles
in a quantum impurity problem. Physical Review Letters. 2017;119(23). doi:10.1103/PhysRevLett.119.235301
apa: Yakaboylu, E., Deuchert, A., & Lemeshko, M. (2017). Emergence of non-abelian
magnetic monopoles in a quantum impurity problem. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/PhysRevLett.119.235301
chicago: Yakaboylu, Enderalp, Andreas Deuchert, and Mikhail Lemeshko. “Emergence
of Non-Abelian Magnetic Monopoles in a Quantum Impurity Problem.” Physical
Review Letters. American Physical Society, 2017. https://doi.org/10.1103/PhysRevLett.119.235301.
ieee: E. Yakaboylu, A. Deuchert, and M. Lemeshko, “Emergence of non-abelian magnetic
monopoles in a quantum impurity problem,” Physical Review Letters, vol.
119, no. 23. American Physical Society, 2017.
ista: Yakaboylu E, Deuchert A, Lemeshko M. 2017. Emergence of non-abelian magnetic
monopoles in a quantum impurity problem. Physical Review Letters. 119(23), 235301.
mla: Yakaboylu, Enderalp, et al. “Emergence of Non-Abelian Magnetic Monopoles in
a Quantum Impurity Problem.” Physical Review Letters, vol. 119, no. 23,
235301, American Physical Society, 2017, doi:10.1103/PhysRevLett.119.235301.
short: E. Yakaboylu, A. Deuchert, M. Lemeshko, Physical Review Letters 119 (2017).
date_created: 2018-12-11T11:49:36Z
date_published: 2017-12-06T00:00:00Z
date_updated: 2023-10-10T13:31:54Z
day: '06'
department:
- _id: MiLe
- _id: RoSe
doi: 10.1103/PhysRevLett.119.235301
ec_funded: 1
external_id:
arxiv:
- '1705.05162'
isi:
- '000417132100007'
intvolume: ' 119'
isi: 1
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1705.05162
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 26031614-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29902
name: Quantum rotations in the presence of a many-body environment
publication: Physical Review Letters
publication_identifier:
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
publist_id: '6401'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Emergence of non-abelian magnetic monopoles in a quantum impurity problem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2017'
...
---
_id: '911'
abstract:
- lang: eng
text: We develop a probabilistic technique for colorizing grayscale natural images.
In light of the intrinsic uncertainty of this task, the proposed probabilistic
framework has numerous desirable properties. In particular, our model is able
to produce multiple plausible and vivid colorizations for a given grayscale image
and is one of the first colorization models to provide a proper stochastic sampling
scheme. Moreover, our training procedure is supported by a rigorous theoretical
framework that does not require any ad hoc heuristics and allows for efficient
modeling and learning of the joint pixel color distribution.We demonstrate strong
quantitative and qualitative experimental results on the CIFAR-10 dataset and
the challenging ILSVRC 2012 dataset.
article_processing_charge: No
author:
- first_name: Amélie
full_name: Royer, Amélie
id: 3811D890-F248-11E8-B48F-1D18A9856A87
last_name: Royer
orcid: 0000-0002-8407-0705
- first_name: Alexander
full_name: Kolesnikov, Alexander
id: 2D157DB6-F248-11E8-B48F-1D18A9856A87
last_name: Kolesnikov
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Royer A, Kolesnikov A, Lampert C. Probabilistic image colorization. In: BMVA
Press; 2017:85.1-85.12. doi:10.5244/c.31.85'
apa: 'Royer, A., Kolesnikov, A., & Lampert, C. (2017). Probabilistic image colorization
(p. 85.1-85.12). Presented at the BMVC: British Machine Vision Conference, London,
United Kingdom: BMVA Press. https://doi.org/10.5244/c.31.85'
chicago: Royer, Amélie, Alexander Kolesnikov, and Christoph Lampert. “Probabilistic
Image Colorization,” 85.1-85.12. BMVA Press, 2017. https://doi.org/10.5244/c.31.85.
ieee: 'A. Royer, A. Kolesnikov, and C. Lampert, “Probabilistic image colorization,”
presented at the BMVC: British Machine Vision Conference, London, United Kingdom,
2017, p. 85.1-85.12.'
ista: 'Royer A, Kolesnikov A, Lampert C. 2017. Probabilistic image colorization.
BMVC: British Machine Vision Conference, 85.1-85.12.'
mla: Royer, Amélie, et al. Probabilistic Image Colorization. BMVA Press,
2017, p. 85.1-85.12, doi:10.5244/c.31.85.
short: A. Royer, A. Kolesnikov, C. Lampert, in:, BMVA Press, 2017, p. 85.1-85.12.
conference:
end_date: 2017-09-07
location: London, United Kingdom
name: 'BMVC: British Machine Vision Conference'
start_date: 2017-09-04
date_created: 2018-12-11T11:49:09Z
date_published: 2017-09-01T00:00:00Z
date_updated: 2023-10-16T10:04:02Z
day: '01'
ddc:
- '000'
department:
- _id: ChLa
doi: 10.5244/c.31.85
ec_funded: 1
external_id:
arxiv:
- '1705.04258'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-08-10T07:14:33Z
date_updated: 2020-08-10T07:14:33Z
file_id: '8224'
file_name: 2017_BMVC_Royer.pdf
file_size: 1625363
relation: main_file
success: 1
file_date_updated: 2020-08-10T07:14:33Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 85.1-85.12
project:
- _id: 2532554C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '308036'
name: Lifelong Learning of Visual Scene Understanding
publication_identifier:
eisbn:
- 190172560X
publication_status: published
publisher: BMVA Press
publist_id: '6532'
quality_controlled: '1'
related_material:
record:
- id: '8390'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Probabilistic image colorization
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '1146'
abstract:
- lang: eng
text: 'Aim: The present study was to compare the effects of nicotinic acid and nicotinamide
on the plasma methyl donors, choline and betaine. Methods: Thirty adult subjects
were randomly divided into three groups of equal size, and orally received purified
water (C group), nicotinic acid (300 mg, NA group) or nicotinamide (300 mg, NM
group). Plasma nicotinamide, N 1-methylnicotinamide, homocysteine, betaine and
choline levels before and 1.5-h and 3-h post-dosing, plasma normetanephrine and
metanephrine concentrations at 3-h post-dosing, and the urinary excretion of N
1-methyl-2-pyridone-5-carboxamide during the test period were examined. Results:
The level of 3-h plasma nicotinamide, N 1-methylnicotinamide, homocysteine, the
urinary excretion of N 1-methyl-2-pyridone-5-carboxamide and pulse pressure (PP)
in the NM group was 221%, 3972%, 61%, 1728% and 21.2% higher than that of the
control group (P < 0.01, except homocysteine and PP P < 0.05), while the
3-h plasma betaine, normetanephrine and metanephrine level in the NM group was
24.4%, 9.4% and 11.7% lower (P < 0.05, except betaine P < 0.01), without
significant difference in choline levels. Similar but less pronounced changes
were observed in the NA group, with a lower level of 3-h plasma N 1-methylnicotinamide
(1.90 ± 0.20 μmol/l vs. 3.62 ± 0.27 μmol/l, P < 0.01) and homocysteine (12.85
± 1.39 μmol/l vs. 18.08 ± 1.02 μmol/l, P < 0.05) but a higher level of betaine
(27.44 ± 0.71 μmol/l vs. 23.52 ± 0.61 μmol/l, P < 0.05) than that of the NM
group. Conclusion: The degradation of nicotinamide consumes more betaine than
that of nicotinic acid at identical doses. This difference should be taken into
consideration in niacin fortification. © 2016 Elsevier Ltd and European Society
for Clinical Nutrition and Metabolism.'
acknowledgement: We thank all the participants for their contribution to this study
and volunteers from the Nursing School of Dalian University for their supporting
to collect blood and urine samples of the participants. We also thank Dr. Yasunori
Takayama from National Institute for Physiological Sciences of Japan for his kind
help.
article_processing_charge: No
author:
- first_name: Wuping
full_name: Sun, Wuping
last_name: Sun
- first_name: Ming-Zhu
full_name: Zhai, Ming-Zhu
id: 34009CFA-F248-11E8-B48F-1D18A9856A87
last_name: Zhai
- first_name: Da
full_name: Li, Da
last_name: Li
- first_name: Yiming
full_name: Zhou, Yiming
last_name: Zhou
- first_name: Nana
full_name: Chen, Nana
last_name: Chen
- first_name: Ming
full_name: Guo, Ming
last_name: Guo
- first_name: Shisheng
full_name: Zhou, Shisheng
last_name: Zhou
citation:
ama: Sun W, Zhai M-Z, Li D, et al. Comparison of the effects of nicotinic acid and
nicotinamide degradation on plasma betaine and choline levels. Clinical Nutrition.
2017;36(4):1136-1142. doi:10.1016/j.clnu.2016.07.016
apa: Sun, W., Zhai, M.-Z., Li, D., Zhou, Y., Chen, N., Guo, M., & Zhou, S. (2017).
Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma
betaine and choline levels. Clinical Nutrition. Elsevier. https://doi.org/10.1016/j.clnu.2016.07.016
chicago: Sun, Wuping, Ming-Zhu Zhai, Da Li, Yiming Zhou, Nana Chen, Ming Guo, and
Shisheng Zhou. “Comparison of the Effects of Nicotinic Acid and Nicotinamide Degradation
on Plasma Betaine and Choline Levels.” Clinical Nutrition. Elsevier, 2017.
https://doi.org/10.1016/j.clnu.2016.07.016.
ieee: W. Sun et al., “Comparison of the effects of nicotinic acid and nicotinamide
degradation on plasma betaine and choline levels,” Clinical Nutrition,
vol. 36, no. 4. Elsevier, pp. 1136–1142, 2017.
ista: Sun W, Zhai M-Z, Li D, Zhou Y, Chen N, Guo M, Zhou S. 2017. Comparison of
the effects of nicotinic acid and nicotinamide degradation on plasma betaine and
choline levels. Clinical Nutrition. 36(4), 1136–1142.
mla: Sun, Wuping, et al. “Comparison of the Effects of Nicotinic Acid and Nicotinamide
Degradation on Plasma Betaine and Choline Levels.” Clinical Nutrition,
vol. 36, no. 4, Elsevier, 2017, pp. 1136–42, doi:10.1016/j.clnu.2016.07.016.
short: W. Sun, M.-Z. Zhai, D. Li, Y. Zhou, N. Chen, M. Guo, S. Zhou, Clinical Nutrition
36 (2017) 1136–1142.
date_created: 2018-12-11T11:50:24Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2023-10-16T11:09:39Z
day: '01'
department:
- _id: RySh
doi: 10.1016/j.clnu.2016.07.016
intvolume: ' 36'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 1136-1142
publication: Clinical Nutrition
publication_identifier:
issn:
- 0261-5614
publication_status: published
publisher: Elsevier
publist_id: '6212'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the effects of nicotinic acid and nicotinamide degradation on
plasma betaine and choline levels
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2017'
...
---
_id: '84'
abstract:
- lang: eng
text: The advent of high-throughput technologies and the concurrent advances in
information sciences have led to a data revolution in biology. This revolution
is most significant in molecular biology, with an increase in the number and scale
of the “omics” projects over the last decade. Genomics projects, for example,
have produced impressive advances in our knowledge of the information concealed
into genomes, from the many genes that encode for the proteins that are responsible
for most if not all cellular functions, to the noncoding regions that are now
known to provide regulatory functions. Proteomics initiatives help to decipher
the role of post-translation modifications on the protein structures and provide
maps of protein-protein interactions, while functional genomics is the field that
attempts to make use of the data produced by these projects to understand protein
functions. The biggest challenge today is to assimilate the wealth of information
provided by these initiatives into a conceptual framework that will help us decipher
life. For example, the current views of the relationship between protein structure
and function remain fragmented. We know of their sequences, more and more about
their structures, we have information on their biological activities, but we have
difficulties connecting this dotted line into an informed whole. We lack the experimental
and computational tools for directly studying protein structure, function, and
dynamics at the molecular and supra-molecular levels. In this chapter, we review
some of the current developments in building the computational tools that are
needed, focusing on the role that geometry and topology play in these efforts.
One of our goals is to raise the general awareness about the importance of geometric
methods in elucidating the mysterious foundations of our very existence. Another
goal is the broadening of what we consider a geometric algorithm. There is plenty
of valuable no-man’s-land between combinatorial and numerical algorithms, and
it seems opportune to explore this land with a computational-geometric frame of
mind.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Patrice
full_name: Koehl, Patrice
last_name: Koehl
citation:
ama: 'Edelsbrunner H, Koehl P. Computational topology for structural molecular biology.
In: Toth C, O’Rourke J, Goodman J, eds. Handbook of Discrete and Computational
Geometry, Third Edition. Handbook of Discrete and Computational Geometry.
Taylor & Francis; 2017:1709-1735. doi:10.1201/9781315119601'
apa: Edelsbrunner, H., & Koehl, P. (2017). Computational topology for structural
molecular biology. In C. Toth, J. O’Rourke, & J. Goodman (Eds.), Handbook
of Discrete and Computational Geometry, Third Edition (pp. 1709–1735). Taylor
& Francis. https://doi.org/10.1201/9781315119601
chicago: Edelsbrunner, Herbert, and Patrice Koehl. “Computational Topology for Structural
Molecular Biology.” In Handbook of Discrete and Computational Geometry, Third
Edition, edited by Csaba Toth, Joseph O’Rourke, and Jacob Goodman, 1709–35.
Handbook of Discrete and Computational Geometry. Taylor & Francis, 2017. https://doi.org/10.1201/9781315119601.
ieee: H. Edelsbrunner and P. Koehl, “Computational topology for structural molecular
biology,” in Handbook of Discrete and Computational Geometry, Third Edition,
C. Toth, J. O’Rourke, and J. Goodman, Eds. Taylor & Francis, 2017, pp. 1709–1735.
ista: 'Edelsbrunner H, Koehl P. 2017.Computational topology for structural molecular
biology. In: Handbook of Discrete and Computational Geometry, Third Edition. ,
1709–1735.'
mla: Edelsbrunner, Herbert, and Patrice Koehl. “Computational Topology for Structural
Molecular Biology.” Handbook of Discrete and Computational Geometry, Third
Edition, edited by Csaba Toth et al., Taylor & Francis, 2017, pp. 1709–35,
doi:10.1201/9781315119601.
short: H. Edelsbrunner, P. Koehl, in:, C. Toth, J. O’Rourke, J. Goodman (Eds.),
Handbook of Discrete and Computational Geometry, Third Edition, Taylor & Francis,
2017, pp. 1709–1735.
date_created: 2018-12-11T11:44:32Z
date_published: 2017-11-09T00:00:00Z
date_updated: 2023-10-16T11:15:22Z
day: '09'
department:
- _id: HeEd
doi: 10.1201/9781315119601
editor:
- first_name: Csaba
full_name: Toth, Csaba
last_name: Toth
- first_name: Joseph
full_name: O'Rourke, Joseph
last_name: O'Rourke
- first_name: Jacob
full_name: Goodman, Jacob
last_name: Goodman
language:
- iso: eng
month: '11'
oa_version: None
page: 1709 - 1735
publication: Handbook of Discrete and Computational Geometry, Third Edition
publication_identifier:
eisbn:
- '9781498711425'
publication_status: published
publisher: Taylor & Francis
publist_id: '7970'
quality_controlled: '1'
scopus_import: '1'
series_title: Handbook of Discrete and Computational Geometry
status: public
title: Computational topology for structural molecular biology
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '627'
abstract:
- lang: eng
text: Beige adipocytes are a new type of recruitable brownish adipocytes, with highly
mitochondrial membrane uncoupling protein 1 expression and thermogenesis. Beige
adipocytes were found among white adipocytes, especially in subcutaneous white
adipose tissue (sWAT). Therefore, beige adipocytes may be involved in the regulation
of energy metabolism and fat deposition. Transient receptor potential melastatin
8 (TRPM8), a Ca2+-permeable non-selective cation channel, plays vital roles in
the regulation of various cellular functions. It has been reported that TRPM8
activation enhanced the thermogenic function of brown adiposytes. However, the
involvement of TRPM8 in the thermogenic function of WAT remains unexplored. Our
data revealed that TRPM8 was expressed in mouse white adipocytes at mRNA, protein
and functional levels. The mRNA expression of Trpm8 was significantly increased
in the differentiated white adipocytes than pre-adipocytes. Moreover, activation
of TRPM8 by menthol enhanced the expression of thermogenic genes in cultured white
aidpocytes. And menthol-induced increases of the thermogenic genes in white adipocytes
was inhibited by either KT5720 (a protein kinase A inhibitor) or BAPTA-AM. In
addition, high fat diet (HFD)-induced obesity in mice was significantly recovered
by co-treatment with menthol. Dietary menthol enhanced WAT "browning"
and improved glucose metabolism in HFD-induced obesity mice as well. Therefore,
we concluded that TRPM8 might be involved in WAT "browning" by increasing
the expression levels of genes related to thermogenesis and energy metabolism.
And dietary menthol could be a novel approach for combating human obesity and
related metabolic diseases.
article_processing_charge: No
author:
- first_name: Changyu
full_name: Jiang, Changyu
last_name: Jiang
- first_name: Ming-Zhu
full_name: Zhai, Ming-Zhu
id: 34009CFA-F248-11E8-B48F-1D18A9856A87
last_name: Zhai
- first_name: Dong
full_name: Yan, Dong
last_name: Yan
- first_name: Da
full_name: Li, Da
last_name: Li
- first_name: Chen
full_name: Li, Chen
last_name: Li
- first_name: Yonghong
full_name: Zhang, Yonghong
last_name: Zhang
- first_name: Lizu
full_name: Xiao, Lizu
last_name: Xiao
- first_name: Donglin
full_name: Xiong, Donglin
last_name: Xiong
- first_name: Qiwen
full_name: Deng, Qiwen
last_name: Deng
- first_name: Wuping
full_name: Sun, Wuping
last_name: Sun
citation:
ama: Jiang C, Zhai M-Z, Yan D, et al. Dietary menthol-induced TRPM8 activation enhances
WAT “browning” and ameliorates diet-induced obesity. Oncotarget. 2017;8(43):75114-75126.
doi:10.18632/oncotarget.20540
apa: Jiang, C., Zhai, M.-Z., Yan, D., Li, D., Li, C., Zhang, Y., … Sun, W. (2017).
Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates
diet-induced obesity. Oncotarget. Impact Journals. https://doi.org/10.18632/oncotarget.20540
chicago: Jiang, Changyu, Ming-Zhu Zhai, Dong Yan, Da Li, Chen Li, Yonghong Zhang,
Lizu Xiao, Donglin Xiong, Qiwen Deng, and Wuping Sun. “Dietary Menthol-Induced
TRPM8 Activation Enhances WAT ‘Browning’ and Ameliorates Diet-Induced Obesity.”
Oncotarget. Impact Journals, 2017. https://doi.org/10.18632/oncotarget.20540.
ieee: C. Jiang et al., “Dietary menthol-induced TRPM8 activation enhances
WAT ‘browning’ and ameliorates diet-induced obesity,” Oncotarget, vol.
8, no. 43. Impact Journals, pp. 75114–75126, 2017.
ista: Jiang C, Zhai M-Z, Yan D, Li D, Li C, Zhang Y, Xiao L, Xiong D, Deng Q, Sun
W. 2017. Dietary menthol-induced TRPM8 activation enhances WAT “browning” and
ameliorates diet-induced obesity. Oncotarget. 8(43), 75114–75126.
mla: Jiang, Changyu, et al. “Dietary Menthol-Induced TRPM8 Activation Enhances WAT
‘Browning’ and Ameliorates Diet-Induced Obesity.” Oncotarget, vol. 8, no.
43, Impact Journals, 2017, pp. 75114–26, doi:10.18632/oncotarget.20540.
short: C. Jiang, M.-Z. Zhai, D. Yan, D. Li, C. Li, Y. Zhang, L. Xiao, D. Xiong,
Q. Deng, W. Sun, Oncotarget 8 (2017) 75114–75126.
date_created: 2018-12-11T11:47:34Z
date_published: 2017-08-24T00:00:00Z
date_updated: 2023-10-17T08:56:37Z
day: '24'
ddc:
- '571'
department:
- _id: RySh
doi: 10.18632/oncotarget.20540
file:
- access_level: open_access
checksum: 2219e5348bbfe1aac2725aa620c33280
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:15Z
date_updated: 2020-07-14T12:47:26Z
file_id: '5201'
file_name: IST-2017-907-v1+1_20540-294640-4-PB.pdf
file_size: 6101606
relation: main_file
file_date_updated: 2020-07-14T12:47:26Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '43'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 75114 - 75126
publication: Oncotarget
publication_identifier:
issn:
- 1949-2553
publication_status: published
publisher: Impact Journals
publist_id: '7167'
pubrep_id: '907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dietary menthol-induced TRPM8 activation enhances WAT “browning” and ameliorates
diet-induced obesity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2017'
...
---
_id: '1007'
abstract:
- lang: eng
text: 'A nonlinear system possesses an invariance with respect to a set of transformations
if its output dynamics remain invariant when transforming the input, and adjusting
the initial condition accordingly. Most research has focused on invariances with
respect to time-independent pointwise transformations like translational-invariance
(u(t) -> u(t) + p, p in R) or scale-invariance (u(t) -> pu(t), p in R>0).
In this article, we introduce the concept of s0-invariances with respect to continuous
input transformations exponentially growing/decaying over time. We show that s0-invariant
systems not only encompass linear time-invariant (LTI) systems with transfer functions
having an irreducible zero at s0 in R, but also that the input/output relationship
of nonlinear s0-invariant systems possesses properties well known from their linear
counterparts. Furthermore, we extend the concept of s0-invariances to second-
and higher-order s0-invariances, corresponding to invariances with respect to
transformations of the time-derivatives of the input, and encompassing LTI systems
with zeros of multiplicity two or higher. Finally, we show that nth-order 0-invariant
systems realize – under mild conditions – nth-order nonlinear differential operators:
when excited by an input of a characteristic functional form, the system’s output
converges to a constant value only depending on the nth (nonlinear) derivative
of the input.'
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Moritz
full_name: Lang, Moritz
id: 29E0800A-F248-11E8-B48F-1D18A9856A87
last_name: Lang
- first_name: Eduardo
full_name: Sontag, Eduardo
last_name: Sontag
citation:
ama: Lang M, Sontag E. Zeros of nonlinear systems with input invariances. Automatica.
2017;81C:46-55. doi:10.1016/j.automatica.2017.03.030
apa: Lang, M., & Sontag, E. (2017). Zeros of nonlinear systems with input invariances.
Automatica. International Federation of Automatic Control. https://doi.org/10.1016/j.automatica.2017.03.030
chicago: Lang, Moritz, and Eduardo Sontag. “Zeros of Nonlinear Systems with Input
Invariances.” Automatica. International Federation of Automatic Control,
2017. https://doi.org/10.1016/j.automatica.2017.03.030.
ieee: M. Lang and E. Sontag, “Zeros of nonlinear systems with input invariances,”
Automatica, vol. 81C. International Federation of Automatic Control, pp.
46–55, 2017.
ista: Lang M, Sontag E. 2017. Zeros of nonlinear systems with input invariances.
Automatica. 81C, 46–55.
mla: Lang, Moritz, and Eduardo Sontag. “Zeros of Nonlinear Systems with Input Invariances.”
Automatica, vol. 81C, International Federation of Automatic Control, 2017,
pp. 46–55, doi:10.1016/j.automatica.2017.03.030.
short: M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
date_created: 2018-12-11T11:49:39Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-10-17T08:51:18Z
day: '01'
ddc:
- '000'
department:
- _id: CaGu
- _id: GaTk
doi: 10.1016/j.automatica.2017.03.030
ec_funded: 1
external_id:
isi:
- '000403513900006'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:29Z
date_updated: 2018-12-12T10:11:29Z
file_id: '4884'
file_name: IST-2017-813-v1+1_ZerosOfNonlinearSystems.pdf
file_size: 1401954
relation: main_file
file_date_updated: 2018-12-12T10:11:29Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 46 - 55
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Automatica
publication_identifier:
issn:
- 0005-1098
publication_status: published
publisher: International Federation of Automatic Control
publist_id: '6391'
pubrep_id: '813'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zeros of nonlinear systems with input invariances
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 81C
year: '2017'
...