---
_id: '1424'
abstract:
- lang: eng
text: We consider the problem of statistical computations with persistence diagrams,
a summary representation of topological features in data. These diagrams encode
persistent homology, a widely used invariant in topological data analysis. While
several avenues towards a statistical treatment of the diagrams have been explored
recently, we follow an alternative route that is motivated by the success of methods
based on the embedding of probability measures into reproducing kernel Hilbert
spaces. In fact, a positive definite kernel on persistence diagrams has recently
been proposed, connecting persistent homology to popular kernel-based learning
techniques such as support vector machines. However, important properties of that
kernel enabling a principled use in the context of probability measure embeddings
remain to be explored. Our contribution is to close this gap by proving universality
of a variant of the original kernel, and to demonstrate its effective use in twosample
hypothesis testing on synthetic as well as real-world data.
acknowledgement: This work was partially supported by the Austrian Science FUnd, project
no. KLI 00012.
alternative_title:
- Advances in Neural Information Processing Systems
author:
- first_name: Roland
full_name: Kwitt, Roland
last_name: Kwitt
- first_name: Stefan
full_name: Huber, Stefan
id: 4700A070-F248-11E8-B48F-1D18A9856A87
last_name: Huber
orcid: 0000-0002-8871-5814
- first_name: Marc
full_name: Niethammer, Marc
last_name: Niethammer
- first_name: Weili
full_name: Lin, Weili
last_name: Lin
- first_name: Ulrich
full_name: Bauer, Ulrich
id: 2ADD483A-F248-11E8-B48F-1D18A9856A87
last_name: Bauer
orcid: 0000-0002-9683-0724
citation:
ama: 'Kwitt R, Huber S, Niethammer M, Lin W, Bauer U. Statistical topological data
analysis-A kernel perspective. In: Vol 28. Neural Information Processing Systems;
2015:3070-3078.'
apa: 'Kwitt, R., Huber, S., Niethammer, M., Lin, W., & Bauer, U. (2015). Statistical
topological data analysis-A kernel perspective (Vol. 28, pp. 3070–3078). Presented
at the NIPS: Neural Information Processing Systems, Montreal, Canada: Neural Information
Processing Systems.'
chicago: Kwitt, Roland, Stefan Huber, Marc Niethammer, Weili Lin, and Ulrich Bauer.
“Statistical Topological Data Analysis-A Kernel Perspective,” 28:3070–78. Neural
Information Processing Systems, 2015.
ieee: 'R. Kwitt, S. Huber, M. Niethammer, W. Lin, and U. Bauer, “Statistical topological
data analysis-A kernel perspective,” presented at the NIPS: Neural Information
Processing Systems, Montreal, Canada, 2015, vol. 28, pp. 3070–3078.'
ista: 'Kwitt R, Huber S, Niethammer M, Lin W, Bauer U. 2015. Statistical topological
data analysis-A kernel perspective. NIPS: Neural Information Processing Systems,
Advances in Neural Information Processing Systems, vol. 28, 3070–3078.'
mla: Kwitt, Roland, et al. Statistical Topological Data Analysis-A Kernel Perspective.
Vol. 28, Neural Information Processing Systems, 2015, pp. 3070–78.
short: R. Kwitt, S. Huber, M. Niethammer, W. Lin, U. Bauer, in:, Neural Information
Processing Systems, 2015, pp. 3070–3078.
conference:
end_date: 2015-12-12
location: Montreal, Canada
name: 'NIPS: Neural Information Processing Systems'
start_date: 2015-12-07
date_created: 2018-12-11T11:51:56Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:50:38Z
day: '01'
department:
- _id: HeEd
intvolume: ' 28'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://papers.nips.cc/paper/5887-statistical-topological-data-analysis-a-kernel-perspective
month: '12'
oa: 1
oa_version: Submitted Version
page: 3070 - 3078
publication_status: published
publisher: Neural Information Processing Systems
publist_id: '5782'
quality_controlled: '1'
status: public
title: Statistical topological data analysis-A kernel perspective
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2015'
...
---
_id: '1430'
abstract:
- lang: eng
text: Evolutionary algorithms (EAs) form a popular optimisation paradigm inspired
by natural evolution. In recent years the field of evolutionary computation has
developed a rigorous analytical theory to analyse their runtime on many illustrative
problems. Here we apply this theory to a simple model of natural evolution. In
the Strong Selection Weak Mutation (SSWM) evolutionary regime the time between
occurrence of new mutations is much longer than the time it takes for a new beneficial
mutation to take over the population. In this situation, the population only contains
copies of one genotype and evolution can be modelled as a (1+1)-type process where
the probability of accepting a new genotype (improvements or worsenings) depends
on the change in fitness. We present an initial runtime analysis of SSWM, quantifying
its performance for various parameters and investigating differences to the (1+1)
EA. We show that SSWM can have a moderate advantage over the (1+1) EA at crossing
fitness valleys and study an example where SSWM outperforms the (1+1) EA by taking
advantage of information on the fitness gradient.
author:
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Dirk
full_name: Sudholt, Dirk
last_name: Sudholt
- first_name: Jorge
full_name: Heredia, Jorge
last_name: Heredia
- first_name: Barbora
full_name: Trubenova, Barbora
id: 42302D54-F248-11E8-B48F-1D18A9856A87
last_name: Trubenova
orcid: 0000-0002-6873-2967
citation:
ama: 'Paixao T, Sudholt D, Heredia J, Trubenova B. First steps towards a runtime
comparison of natural and artificial evolution. In: Proceedings of the 2015
Annual Conference on Genetic and Evolutionary Computation. ACM; 2015:1455-1462.
doi:10.1145/2739480.2754758'
apa: 'Paixao, T., Sudholt, D., Heredia, J., & Trubenova, B. (2015). First steps
towards a runtime comparison of natural and artificial evolution. In Proceedings
of the 2015 Annual Conference on Genetic and Evolutionary Computation (pp.
1455–1462). Madrid, Spain: ACM. https://doi.org/10.1145/2739480.2754758'
chicago: Paixao, Tiago, Dirk Sudholt, Jorge Heredia, and Barbora Trubenova. “First
Steps towards a Runtime Comparison of Natural and Artificial Evolution.” In Proceedings
of the 2015 Annual Conference on Genetic and Evolutionary Computation, 1455–62.
ACM, 2015. https://doi.org/10.1145/2739480.2754758.
ieee: T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards
a runtime comparison of natural and artificial evolution,” in Proceedings of
the 2015 Annual Conference on Genetic and Evolutionary Computation, Madrid,
Spain, 2015, pp. 1455–1462.
ista: 'Paixao T, Sudholt D, Heredia J, Trubenova B. 2015. First steps towards a
runtime comparison of natural and artificial evolution. Proceedings of the 2015
Annual Conference on Genetic and Evolutionary Computation. GECCO: Genetic and
evolutionary computation conference, 1455–1462.'
mla: Paixao, Tiago, et al. “First Steps towards a Runtime Comparison of Natural
and Artificial Evolution.” Proceedings of the 2015 Annual Conference on Genetic
and Evolutionary Computation, ACM, 2015, pp. 1455–62, doi:10.1145/2739480.2754758.
short: T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the
2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp.
1455–1462.
conference:
end_date: 2015-07-15
location: Madrid, Spain
name: 'GECCO: Genetic and evolutionary computation conference'
start_date: 2015-07-11
date_created: 2018-12-11T11:51:58Z
date_published: 2015-07-11T00:00:00Z
date_updated: 2021-01-12T06:50:41Z
day: '11'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1145/2739480.2754758
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1504.06260
month: '07'
oa: 1
oa_version: Preprint
page: 1455 - 1462
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: Proceedings of the 2015 Annual Conference on Genetic and Evolutionary
Computation
publication_status: published
publisher: ACM
publist_id: '5768'
quality_controlled: '1'
scopus_import: 1
status: public
title: First steps towards a runtime comparison of natural and artificial evolution
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1474'
abstract:
- lang: eng
text: Cryptographic access control offers selective access to encrypted data via
a combination of key management and functionality-rich cryptographic schemes,
such as attribute-based encryption. Using this approach, publicly available meta-data
may inadvertently leak information on the access policy that is enforced by cryptography,
which renders cryptographic access control unusable in settings where this information
is highly sensitive. We begin to address this problem by presenting rigorous definitions
for policy privacy in cryptographic access control. For concreteness we set our
results in the model of Role-Based Access Control (RBAC), where we identify and
formalize several different flavors of privacy, however, our framework should
serve as inspiration for other models of access control. Based on our insights
we propose a new system which significantly improves on the privacy properties
of state-of-the-art constructions. Our design is based on a novel type of privacy-preserving
attribute-based encryption, which we introduce and show how to instantiate. We
present our results in the context of a cryptographic RBAC system by Ferrara et
al. (CSF'13), which uses cryptography to control read access to files, while write
access is still delegated to trusted monitors. We give an extension of the construction
that permits cryptographic control over write access. Our construction assumes
that key management uses out-of-band channels between the policy enforcer and
the users but eliminates completely the need for monitoring read/write access
to the data.
article_processing_charge: No
author:
- first_name: Anna
full_name: Ferrara, Anna
last_name: Ferrara
- first_name: Georg
full_name: Fuchsbauer, Georg
id: 46B4C3EE-F248-11E8-B48F-1D18A9856A87
last_name: Fuchsbauer
- first_name: Bin
full_name: Liu, Bin
last_name: Liu
- first_name: Bogdan
full_name: Warinschi, Bogdan
last_name: Warinschi
citation:
ama: 'Ferrara A, Fuchsbauer G, Liu B, Warinschi B. Policy privacy in cryptographic
access control. In: IEEE; 2015:46-60. doi:10.1109/CSF.2015.11'
apa: 'Ferrara, A., Fuchsbauer, G., Liu, B., & Warinschi, B. (2015). Policy privacy
in cryptographic access control (pp. 46–60). Presented at the CSF: Computer Security
Foundations, Verona, Italy: IEEE. https://doi.org/10.1109/CSF.2015.11'
chicago: Ferrara, Anna, Georg Fuchsbauer, Bin Liu, and Bogdan Warinschi. “Policy
Privacy in Cryptographic Access Control,” 46–60. IEEE, 2015. https://doi.org/10.1109/CSF.2015.11.
ieee: 'A. Ferrara, G. Fuchsbauer, B. Liu, and B. Warinschi, “Policy privacy in cryptographic
access control,” presented at the CSF: Computer Security Foundations, Verona,
Italy, 2015, pp. 46–60.'
ista: 'Ferrara A, Fuchsbauer G, Liu B, Warinschi B. 2015. Policy privacy in cryptographic
access control. CSF: Computer Security Foundations, 46–60.'
mla: Ferrara, Anna, et al. Policy Privacy in Cryptographic Access Control.
IEEE, 2015, pp. 46–60, doi:10.1109/CSF.2015.11.
short: A. Ferrara, G. Fuchsbauer, B. Liu, B. Warinschi, in:, IEEE, 2015, pp. 46–60.
conference:
end_date: 2015-07-17
location: Verona, Italy
name: 'CSF: Computer Security Foundations'
start_date: 2015-07-13
date_created: 2018-12-11T11:52:14Z
date_published: 2015-09-04T00:00:00Z
date_updated: 2021-01-12T06:50:59Z
day: '04'
department:
- _id: KrPi
doi: 10.1109/CSF.2015.11
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://epubs.surrey.ac.uk/808055/
month: '09'
oa: 1
oa_version: Submitted Version
page: 46-60
project:
- _id: 258C570E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '259668'
name: Provable Security for Physical Cryptography
publication_status: published
publisher: IEEE
publist_id: '5722'
quality_controlled: '1'
status: public
title: Policy privacy in cryptographic access control
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1473'
abstract:
- lang: eng
text: In this paper we survey geometric and arithmetic techniques to study the cohomology
of semiprojective hyperkähler manifolds including toric hyperkähler varieties,
Nakajima quiver varieties and moduli spaces of Higgs bundles on Riemann surfaces.
The resulting formulae for their Poincaré polynomials are combinatorial and representation
theoretical in nature. In particular we will look at their Betti numbers and will
establish some results and state some expectations on their asymptotic shape.
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Fernando
full_name: Rodríguez Villegas, Fernando
last_name: Rodríguez Villegas
citation:
ama: Hausel T, Rodríguez Villegas F. Cohomology of large semiprojective hyperkähler
varieties. Asterisque. 2015;2015(370):113-156.
apa: Hausel, T., & Rodríguez Villegas, F. (2015). Cohomology of large semiprojective
hyperkähler varieties. Asterisque. Societe Mathematique de France.
chicago: Hausel, Tamás, and Fernando Rodríguez Villegas. “Cohomology of Large Semiprojective
Hyperkähler Varieties.” Asterisque. Societe Mathematique de France, 2015.
ieee: T. Hausel and F. Rodríguez Villegas, “Cohomology of large semiprojective hyperkähler
varieties,” Asterisque, vol. 2015, no. 370. Societe Mathematique de France,
pp. 113–156, 2015.
ista: Hausel T, Rodríguez Villegas F. 2015. Cohomology of large semiprojective hyperkähler
varieties. Asterisque. 2015(370), 113–156.
mla: Hausel, Tamás, and Fernando Rodríguez Villegas. “Cohomology of Large Semiprojective
Hyperkähler Varieties.” Asterisque, vol. 2015, no. 370, Societe Mathematique
de France, 2015, pp. 113–56.
short: T. Hausel, F. Rodríguez Villegas, Asterisque 2015 (2015) 113–156.
date_created: 2018-12-11T11:52:13Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:50:59Z
day: '01'
extern: 1
intvolume: ' 2015'
issue: '370'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1309.4914
month: '01'
oa: 1
page: 113 - 156
publication: Asterisque
publication_status: published
publisher: Societe Mathematique de France
publist_id: '5723'
quality_controlled: 0
status: public
title: Cohomology of large semiprojective hyperkähler varieties
type: review
volume: 2015
year: '2015'
...
---
_id: '1483'
abstract:
- lang: eng
text: Topological data analysis offers a rich source of valuable information to
study vision problems. Yet, so far we lack a theoretically sound connection to
popular kernel-based learning techniques, such as kernel SVMs or kernel PCA. In
this work, we establish such a connection by designing a multi-scale kernel for
persistence diagrams, a stable summary representation of topological features
in data. We show that this kernel is positive definite and prove its stability
with respect to the 1-Wasserstein distance. Experiments on two benchmark datasets
for 3D shape classification/retrieval and texture recognition show considerable
performance gains of the proposed method compared to an alternative approach that
is based on the recently introduced persistence landscapes.
author:
- first_name: Jan
full_name: Reininghaus, Jan
id: 4505473A-F248-11E8-B48F-1D18A9856A87
last_name: Reininghaus
- first_name: Stefan
full_name: Huber, Stefan
id: 4700A070-F248-11E8-B48F-1D18A9856A87
last_name: Huber
orcid: 0000-0002-8871-5814
- first_name: Ulrich
full_name: Bauer, Ulrich
id: 2ADD483A-F248-11E8-B48F-1D18A9856A87
last_name: Bauer
orcid: 0000-0002-9683-0724
- first_name: Roland
full_name: Kwitt, Roland
last_name: Kwitt
citation:
ama: 'Reininghaus J, Huber S, Bauer U, Kwitt R. A stable multi-scale kernel for
topological machine learning. In: IEEE; 2015:4741-4748. doi:10.1109/CVPR.2015.7299106'
apa: 'Reininghaus, J., Huber, S., Bauer, U., & Kwitt, R. (2015). A stable multi-scale
kernel for topological machine learning (pp. 4741–4748). Presented at the CVPR:
Computer Vision and Pattern Recognition, Boston, MA, USA: IEEE. https://doi.org/10.1109/CVPR.2015.7299106'
chicago: Reininghaus, Jan, Stefan Huber, Ulrich Bauer, and Roland Kwitt. “A Stable
Multi-Scale Kernel for Topological Machine Learning,” 4741–48. IEEE, 2015. https://doi.org/10.1109/CVPR.2015.7299106.
ieee: 'J. Reininghaus, S. Huber, U. Bauer, and R. Kwitt, “A stable multi-scale kernel
for topological machine learning,” presented at the CVPR: Computer Vision and
Pattern Recognition, Boston, MA, USA, 2015, pp. 4741–4748.'
ista: 'Reininghaus J, Huber S, Bauer U, Kwitt R. 2015. A stable multi-scale kernel
for topological machine learning. CVPR: Computer Vision and Pattern Recognition,
4741–4748.'
mla: Reininghaus, Jan, et al. A Stable Multi-Scale Kernel for Topological Machine
Learning. IEEE, 2015, pp. 4741–48, doi:10.1109/CVPR.2015.7299106.
short: J. Reininghaus, S. Huber, U. Bauer, R. Kwitt, in:, IEEE, 2015, pp. 4741–4748.
conference:
end_date: 2015-06-12
location: Boston, MA, USA
name: 'CVPR: Computer Vision and Pattern Recognition'
start_date: 2015-06-07
date_created: 2018-12-11T11:52:17Z
date_published: 2015-10-14T00:00:00Z
date_updated: 2021-01-12T06:51:03Z
day: '14'
department:
- _id: HeEd
doi: 10.1109/CVPR.2015.7299106
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1412.6821
month: '10'
oa: 1
oa_version: Preprint
page: 4741 - 4748
publication_identifier:
eisbn:
- '978-1-4673-6964-0 '
publication_status: published
publisher: IEEE
publist_id: '5709'
scopus_import: 1
status: public
title: A stable multi-scale kernel for topological machine learning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1498'
abstract:
- lang: eng
text: Fault-tolerant distributed algorithms play an important role in many critical/high-availability
applications. These algorithms are notoriously difficult to implement correctly,
due to asynchronous communication and the occurrence of faults, such as the network
dropping messages or computers crashing. Nonetheless there is surprisingly little
language and verification support to build distributed systems based on fault-tolerant
algorithms. In this paper, we present some of the challenges that a designer has
to overcome to implement a fault-tolerant distributed system. Then we review different
models that have been proposed to reason about distributed algorithms and sketch
how such a model can form the basis for a domain-specific programming language.
Adopting a high-level programming model can simplify the programmer's life and
make the code amenable to automated verification, while still compiling to efficiently
executable code. We conclude by summarizing the current status of an ongoing language
design and implementation project that is based on this idea.
alternative_title:
- LIPIcs
author:
- first_name: Cezara
full_name: Dragoi, Cezara
id: 2B2B5ED0-F248-11E8-B48F-1D18A9856A87
last_name: Dragoi
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Damien
full_name: Zufferey, Damien
id: 4397AC76-F248-11E8-B48F-1D18A9856A87
last_name: Zufferey
orcid: 0000-0002-3197-8736
citation:
ama: Dragoi C, Henzinger TA, Zufferey D. The need for language support for fault-tolerant
distributed systems. 2015;32:90-102. doi:10.4230/LIPIcs.SNAPL.2015.90
apa: 'Dragoi, C., Henzinger, T. A., & Zufferey, D. (2015). The need for language
support for fault-tolerant distributed systems. Presented at the SNAPL: Summit
oN Advances in Programming Languages, Asilomar, CA, United States: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.SNAPL.2015.90'
chicago: Dragoi, Cezara, Thomas A Henzinger, and Damien Zufferey. “The Need for
Language Support for Fault-Tolerant Distributed Systems.” Leibniz International
Proceedings in Informatics. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015. https://doi.org/10.4230/LIPIcs.SNAPL.2015.90.
ieee: C. Dragoi, T. A. Henzinger, and D. Zufferey, “The need for language support
for fault-tolerant distributed systems,” vol. 32. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, pp. 90–102, 2015.
ista: Dragoi C, Henzinger TA, Zufferey D. 2015. The need for language support for
fault-tolerant distributed systems. 32, 90–102.
mla: Dragoi, Cezara, et al. The Need for Language Support for Fault-Tolerant
Distributed Systems. Vol. 32, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015, pp. 90–102, doi:10.4230/LIPIcs.SNAPL.2015.90.
short: C. Dragoi, T.A. Henzinger, D. Zufferey, 32 (2015) 90–102.
conference:
end_date: 2015-05-06
location: Asilomar, CA, United States
name: 'SNAPL: Summit oN Advances in Programming Languages'
start_date: 2015-05-03
date_created: 2018-12-11T11:52:22Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2020-08-11T10:09:14Z
day: '01'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.4230/LIPIcs.SNAPL.2015.90
ec_funded: 1
file:
- access_level: open_access
checksum: cf5e94baa89a2dc4c5de01abc676eda8
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:02Z
date_updated: 2020-07-14T12:44:58Z
file_id: '5050'
file_name: IST-2016-499-v1+1_9.pdf
file_size: 489362
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 32'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 90 - 102
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Moderne Concurrency Paradigms
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication_identifier:
isbn:
- '978-3-939897-80-4 '
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5681'
pubrep_id: '499'
quality_controlled: '1'
scopus_import: 1
series_title: Leibniz International Proceedings in Informatics
status: public
title: The need for language support for fault-tolerant distributed systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2015'
...
---
_id: '1497'
abstract:
- lang: eng
text: Detecting allelic biases from high-throughput sequencing data requires an
approach that maximises sensitivity while minimizing false positives. Here, we
present Allelome.PRO, an automated user-friendly bioinformatics pipeline, which
uses high-throughput sequencing data from reciprocal crosses of two genetically
distinct mouse strains to detect allele-specific expression and chromatin modifications.
Allelome.PRO extends approaches used in previous studies that exclusively analyzed
imprinted expression to give a complete picture of the ‘allelome’ by automatically
categorising the allelic expression of all genes in a given cell type into imprinted,
strain-biased, biallelic or non-informative. Allelome.PRO offers increased sensitivity
to analyze lowly expressed transcripts, together with a robust false discovery
rate empirically calculated from variation in the sequencing data. We used RNA-seq
data from mouse embryonic fibroblasts from F1 reciprocal crosses to determine
a biologically relevant allelic ratio cutoff, and define for the first time an
entire allelome. Furthermore, we show that Allelome.PRO detects differential enrichment
of H3K4me3 over promoters from ChIP-seq data validating the RNA-seq results. This
approach can be easily extended to analyze histone marks of active enhancers,
or transcription factor binding sites and therefore provides a powerful tool to
identify candidate cis regulatory elements genome wide.
acknowledgement: "Austrian Science Fund [FWF P25185-B22, FWF F4302- B09, FWFW1207-B09].
Funding for open access charge: Austrian Science Fund.\r\nWe thank Florian Breitwieser
for advice during the early stages of this project. High-throughput sequencing was
conducted by the Biomedical Sequencing Facility (BSF) at CeMM in Vienna."
article_number: e146
author:
- first_name: Daniel
full_name: Andergassen, Daniel
last_name: Andergassen
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
- first_name: Tomasz
full_name: Kulinski, Tomasz
last_name: Kulinski
- first_name: Philipp
full_name: Guenzl, Philipp
last_name: Guenzl
- first_name: Philipp
full_name: Bammer, Philipp
last_name: Bammer
- first_name: Denise
full_name: Barlow, Denise
last_name: Barlow
- first_name: Florian
full_name: Pauler, Florian
last_name: Pauler
- first_name: Quanah
full_name: Hudson, Quanah
last_name: Hudson
citation:
ama: Andergassen D, Dotter C, Kulinski T, et al. Allelome.PRO, a pipeline to define
allele-specific genomic features from high-throughput sequencing data. Nucleic
Acids Research. 2015;43(21). doi:10.1093/nar/gkv727
apa: Andergassen, D., Dotter, C., Kulinski, T., Guenzl, P., Bammer, P., Barlow,
D., … Hudson, Q. (2015). Allelome.PRO, a pipeline to define allele-specific genomic
features from high-throughput sequencing data. Nucleic Acids Research.
Oxford University Press. https://doi.org/10.1093/nar/gkv727
chicago: Andergassen, Daniel, Christoph Dotter, Tomasz Kulinski, Philipp Guenzl,
Philipp Bammer, Denise Barlow, Florian Pauler, and Quanah Hudson. “Allelome.PRO,
a Pipeline to Define Allele-Specific Genomic Features from High-Throughput Sequencing
Data.” Nucleic Acids Research. Oxford University Press, 2015. https://doi.org/10.1093/nar/gkv727.
ieee: D. Andergassen et al., “Allelome.PRO, a pipeline to define allele-specific
genomic features from high-throughput sequencing data,” Nucleic Acids Research,
vol. 43, no. 21. Oxford University Press, 2015.
ista: Andergassen D, Dotter C, Kulinski T, Guenzl P, Bammer P, Barlow D, Pauler
F, Hudson Q. 2015. Allelome.PRO, a pipeline to define allele-specific genomic
features from high-throughput sequencing data. Nucleic Acids Research. 43(21),
e146.
mla: Andergassen, Daniel, et al. “Allelome.PRO, a Pipeline to Define Allele-Specific
Genomic Features from High-Throughput Sequencing Data.” Nucleic Acids Research,
vol. 43, no. 21, e146, Oxford University Press, 2015, doi:10.1093/nar/gkv727.
short: D. Andergassen, C. Dotter, T. Kulinski, P. Guenzl, P. Bammer, D. Barlow,
F. Pauler, Q. Hudson, Nucleic Acids Research 43 (2015).
date_created: 2018-12-11T11:52:22Z
date_published: 2015-07-21T00:00:00Z
date_updated: 2021-01-12T06:51:09Z
day: '21'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1093/nar/gkv727
file:
- access_level: open_access
checksum: 385b83854fd0eb2e4f386867da2823e2
content_type: application/pdf
creator: dernst
date_created: 2018-12-20T14:18:57Z
date_updated: 2020-07-14T12:44:58Z
file_id: '5768'
file_name: 2015_NucleicAcidsRes_Andergassen.pdf
file_size: 6863297
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 43'
issue: '21'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Nucleic Acids Research
publication_status: published
publisher: Oxford University Press
publist_id: '5682'
quality_controlled: '1'
scopus_import: 1
status: public
title: Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput
sequencing data
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1499'
abstract:
- lang: eng
text: "We consider weighted automata with both positive and negative integer weights
on edges and\r\nstudy the problem of synchronization using adaptive strategies
that may only observe whether\r\nthe current weight-level is negative or nonnegative.
We show that the synchronization problem is decidable in polynomial time for deterministic
weighted automata."
acknowledgement: "The research leading to these results has received funding from
the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement
601148 (CASSTING), EU FP7 FET project SENSATION, Sino-Danish Basic Research Center
IDAE4CPS, the European Research Council (ERC) under grant agreement 267989 (QUAREM),
the Austrian Science Fund (FWF) project S11402-N23 (RiSE) and Z211-N23 (Wittgenstein
Award), the Czech Science Foundation under grant agreement P202/12/G061, and People
Programme (Marie Curie Actions) of the European Union’s Seventh Framework\r\nProgramme
(FP7/2007-2013) REA Grant No 291734."
alternative_title:
- LIPIcs
author:
- first_name: Jan
full_name: Kretinsky, Jan
id: 44CEF464-F248-11E8-B48F-1D18A9856A87
last_name: Kretinsky
orcid: 0000-0002-8122-2881
- first_name: Kim
full_name: Larsen, Kim
last_name: Larsen
- first_name: Simon
full_name: Laursen, Simon
last_name: Laursen
- first_name: Jiří
full_name: Srba, Jiří
last_name: Srba
citation:
ama: 'Kretinsky J, Larsen K, Laursen S, Srba J. Polynomial time decidability of
weighted synchronization under partial observability. In: Vol 42. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik; 2015:142-154. doi:10.4230/LIPIcs.CONCUR.2015.142'
apa: 'Kretinsky, J., Larsen, K., Laursen, S., & Srba, J. (2015). Polynomial
time decidability of weighted synchronization under partial observability (Vol.
42, pp. 142–154). Presented at the CONCUR: Concurrency Theory, Madrid, Spain:
Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2015.142'
chicago: Kretinsky, Jan, Kim Larsen, Simon Laursen, and Jiří Srba. “Polynomial Time
Decidability of Weighted Synchronization under Partial Observability,” 42:142–54.
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. https://doi.org/10.4230/LIPIcs.CONCUR.2015.142.
ieee: 'J. Kretinsky, K. Larsen, S. Laursen, and J. Srba, “Polynomial time decidability
of weighted synchronization under partial observability,” presented at the CONCUR:
Concurrency Theory, Madrid, Spain, 2015, vol. 42, pp. 142–154.'
ista: 'Kretinsky J, Larsen K, Laursen S, Srba J. 2015. Polynomial time decidability
of weighted synchronization under partial observability. CONCUR: Concurrency Theory,
LIPIcs, vol. 42, 142–154.'
mla: Kretinsky, Jan, et al. Polynomial Time Decidability of Weighted Synchronization
under Partial Observability. Vol. 42, Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2015, pp. 142–54, doi:10.4230/LIPIcs.CONCUR.2015.142.
short: J. Kretinsky, K. Larsen, S. Laursen, J. Srba, in:, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2015, pp. 142–154.
conference:
end_date: 2015-09-04
location: Madrid, Spain
name: 'CONCUR: Concurrency Theory'
start_date: 2015-09-01
date_created: 2018-12-11T11:52:22Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2021-01-12T06:51:10Z
day: '01'
ddc:
- '000'
- '003'
department:
- _id: ToHe
- _id: KrCh
doi: 10.4230/LIPIcs.CONCUR.2015.142
ec_funded: 1
file:
- access_level: open_access
checksum: 49eb5021caafaabe5356c65b9c5f8c9c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:12Z
date_updated: 2020-07-14T12:44:58Z
file_id: '4672'
file_name: IST-2016-498-v1+1_32.pdf
file_size: 623563
relation: main_file
file_date_updated: 2020-07-14T12:44:58Z
has_accepted_license: '1'
intvolume: ' 42'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 142 - 154
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5680'
pubrep_id: '498'
quality_controlled: '1'
scopus_import: 1
status: public
title: Polynomial time decidability of weighted synchronization under partial observability
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2015'
...
---
_id: '1495'
abstract:
- lang: eng
text: 'Motivated by biological questions, we study configurations of equal-sized
disks in the Euclidean plane that neither pack nor cover. Measuring the quality
by the probability that a random point lies in exactly one disk, we show that
the regular hexagonal grid gives the maximum among lattice configurations. '
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Mabel
full_name: Iglesias Ham, Mabel
id: 41B58C0C-F248-11E8-B48F-1D18A9856A87
last_name: Iglesias Ham
- first_name: Vitaliy
full_name: Kurlin, Vitaliy
last_name: Kurlin
citation:
ama: 'Edelsbrunner H, Iglesias Ham M, Kurlin V. Relaxed disk packing. In: Proceedings
of the 27th Canadian Conference on Computational Geometry. Vol 2015-August.
Queen’s University; 2015:128-135.'
apa: 'Edelsbrunner, H., Iglesias Ham, M., & Kurlin, V. (2015). Relaxed disk
packing. In Proceedings of the 27th Canadian Conference on Computational Geometry
(Vol. 2015–August, pp. 128–135). Ontario, Canada: Queen’s University.'
chicago: Edelsbrunner, Herbert, Mabel Iglesias Ham, and Vitaliy Kurlin. “Relaxed
Disk Packing.” In Proceedings of the 27th Canadian Conference on Computational
Geometry, 2015–August:128–35. Queen’s University, 2015.
ieee: H. Edelsbrunner, M. Iglesias Ham, and V. Kurlin, “Relaxed disk packing,” in
Proceedings of the 27th Canadian Conference on Computational Geometry,
Ontario, Canada, 2015, vol. 2015–August, pp. 128–135.
ista: 'Edelsbrunner H, Iglesias Ham M, Kurlin V. 2015. Relaxed disk packing. Proceedings
of the 27th Canadian Conference on Computational Geometry. CCCG: Canadian Conference
on Computational Geometry vol. 2015–August, 128–135.'
mla: Edelsbrunner, Herbert, et al. “Relaxed Disk Packing.” Proceedings of the
27th Canadian Conference on Computational Geometry, vol. 2015–August, Queen’s
University, 2015, pp. 128–35.
short: H. Edelsbrunner, M. Iglesias Ham, V. Kurlin, in:, Proceedings of the 27th
Canadian Conference on Computational Geometry, Queen’s University, 2015, pp. 128–135.
conference:
end_date: 2015-08-12
location: Ontario, Canada
name: 'CCCG: Canadian Conference on Computational Geometry'
start_date: 2015-08-10
date_created: 2018-12-11T11:52:21Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:09Z
day: '01'
department:
- _id: HeEd
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1505.03402
month: '08'
oa: 1
oa_version: Submitted Version
page: 128-135
project:
- _id: 255D761E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '318493'
name: Topological Complex Systems
publication: Proceedings of the 27th Canadian Conference on Computational Geometry
publication_status: published
publisher: Queen's University
publist_id: '5684'
quality_controlled: '1'
scopus_import: 1
status: public
title: Relaxed disk packing
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 2015-August
year: '2015'
...
---
_id: '1504'
abstract:
- lang: eng
text: Let Q = (Q1, . . . , Qn) be a random vector drawn from the uniform distribution
on the set of all n! permutations of {1, 2, . . . , n}. Let Z = (Z1, . . . , Zn),
where Zj is the mean zero variance one random variable obtained by centralizing
and normalizing Qj , j = 1, . . . , n. Assume that Xi , i = 1, . . . ,p are i.i.d.
copies of 1/√ p Z and X = Xp,n is the p × n random matrix with Xi as its ith row.
Then Sn = XX is called the p × n Spearman's rank correlation matrix which can
be regarded as a high dimensional extension of the classical nonparametric statistic
Spearman's rank correlation coefficient between two independent random variables.
In this paper, we establish a CLT for the linear spectral statistics of this nonparametric
random matrix model in the scenario of high dimension, namely, p = p(n) and p/n→c
∈ (0,∞) as n→∞.We propose a novel evaluation scheme to estimate the core quantity
in Anderson and Zeitouni's cumulant method in [Ann. Statist. 36 (2008) 2553-2576]
to bypass the so-called joint cumulant summability. In addition, we raise a two-step
comparison approach to obtain the explicit formulae for the mean and covariance
functions in the CLT. Relying on this CLT, we then construct a distribution-free
statistic to test complete independence for components of random vectors. Owing
to the nonparametric property, we can use this test on generally distributed random
variables including the heavy-tailed ones.
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Liang
full_name: Lin, Liang
last_name: Lin
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Lin L, Pan G, Zhou W. Spectral statistics of large dimensional spearman
s rank correlation matrix and its application. Annals of Statistics. 2015;43(6):2588-2623.
doi:10.1214/15-AOS1353
apa: Bao, Z., Lin, L., Pan, G., & Zhou, W. (2015). Spectral statistics of large
dimensional spearman s rank correlation matrix and its application. Annals
of Statistics. Institute of Mathematical Statistics. https://doi.org/10.1214/15-AOS1353
chicago: Bao, Zhigang, Liang Lin, Guangming Pan, and Wang Zhou. “Spectral Statistics
of Large Dimensional Spearman s Rank Correlation Matrix and Its Application.”
Annals of Statistics. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/15-AOS1353.
ieee: Z. Bao, L. Lin, G. Pan, and W. Zhou, “Spectral statistics of large dimensional
spearman s rank correlation matrix and its application,” Annals of Statistics,
vol. 43, no. 6. Institute of Mathematical Statistics, pp. 2588–2623, 2015.
ista: Bao Z, Lin L, Pan G, Zhou W. 2015. Spectral statistics of large dimensional
spearman s rank correlation matrix and its application. Annals of Statistics.
43(6), 2588–2623.
mla: Bao, Zhigang, et al. “Spectral Statistics of Large Dimensional Spearman s Rank
Correlation Matrix and Its Application.” Annals of Statistics, vol. 43,
no. 6, Institute of Mathematical Statistics, 2015, pp. 2588–623, doi:10.1214/15-AOS1353.
short: Z. Bao, L. Lin, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 2588–2623.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
doi: 10.1214/15-AOS1353
extern: '1'
intvolume: ' 43'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1312.5119
month: '12'
oa: 1
oa_version: Published Version
page: 2588 - 2623
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5674'
quality_controlled: '1'
status: public
title: Spectral statistics of large dimensional spearman s rank correlation matrix
and its application
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1500'
abstract:
- lang: eng
text: In this poster, we present methods for randomly generating hybrid automata
with affine differential equations, invariants, guards, and assignments. Selecting
an arbitrary affine function from the set of all affine functions results in a
low likelihood of generating hybrid automata with diverse and interesting behaviors,
as there are an uncountable number of elements in the set of all affine functions.
Instead, we partition the set of all affine functions into potentially interesting
classes and randomly select elements from these classes. For example, we partition
the set of all affine differential equations by using restrictions on eigenvalues
such as those that yield stable, unstable, etc. equilibrium points. We partition
the components describing discrete behavior (guards, assignments, and invariants)
to allow either time-dependent or state-dependent switching, and in particular
provide the ability to generate subclasses of piecewise-affine hybrid automata.
Our preliminary experimental results with a prototype tool called HyRG (Hybrid
Random Generator) illustrate the feasibility of this generation method to automatically
create standard hybrid automaton examples like the bouncing ball and thermostat.
alternative_title:
- '18th ACM International Conference on Hybrid Systems: Computation and Control, HSCC
2015'
author:
- first_name: Luan
full_name: Nguyen, Luan V
last_name: Nguyen
- first_name: Christian
full_name: Christian Schilling
id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
last_name: Schilling
orcid: 0000-0003-3658-1065
- first_name: Sergiy
full_name: Sergiy Bogomolov
id: 369D9A44-F248-11E8-B48F-1D18A9856A87
last_name: Bogomolov
orcid: 0000-0002-0686-0365
- first_name: Taylor
full_name: Johnson, Taylor T
last_name: Johnson
citation:
ama: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. Poster: HyRG: A Random Generation
Tool for Affine Hybrid Automata. Springer; 2015:289-290. doi:10.1145/2728606.2728650'
apa: 'Nguyen, L., Schilling, C., Bogomolov, S., & Johnson, T. (2015). Poster:
HyRG: A random generation tool for affine hybrid automata. HSCC: Hybrid
Systems - Computation and Control (pp. 289–290). Springer. https://doi.org/10.1145/2728606.2728650'
chicago: 'Nguyen, Luan, Christian Schilling, Sergiy Bogomolov, and Taylor Johnson.
Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata. HSCC:
Hybrid Systems - Computation and Control. Springer, 2015. https://doi.org/10.1145/2728606.2728650.'
ieee: 'L. Nguyen, C. Schilling, S. Bogomolov, and T. Johnson, Poster: HyRG: A
random generation tool for affine hybrid automata. Springer, 2015, pp. 289–290.'
ista: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. 2015. Poster: HyRG: A random
generation tool for affine hybrid automata, Springer,p.'
mla: 'Nguyen, Luan, et al. “Poster: HyRG: A Random Generation Tool for Affine Hybrid
Automata.” HSCC: Hybrid Systems - Computation and Control, Springer, 2015,
pp. 289–90, doi:10.1145/2728606.2728650.'
short: 'L. Nguyen, C. Schilling, S. Bogomolov, T. Johnson, Poster: HyRG: A Random
Generation Tool for Affine Hybrid Automata, Springer, 2015.'
date_created: 2018-12-11T11:52:23Z
date_published: 2015-04-14T00:00:00Z
date_updated: 2019-04-26T07:22:03Z
day: '14'
doi: 10.1145/2728606.2728650
extern: 1
month: '04'
page: 289 - 290
publication: 'HSCC: Hybrid Systems - Computation and Control'
publication_status: published
publisher: Springer
publist_id: '5678'
quality_controlled: 0
status: public
title: 'Poster: HyRG: A random generation tool for affine hybrid automata'
type: conference_poster
year: '2015'
...
---
_id: '1503'
abstract:
- lang: eng
text: A Herman-Avila-Bochi type formula is obtained for the average sum of the top
d Lyapunov exponents over a one-parameter family of double-struck G-cocycles,
where double-struck G is the group that leaves a certain, non-degenerate Hermitian
form of signature (c, d) invariant. The generic example of such a group is the
pseudo-unitary group U(c, d) or, in the case c = d, the Hermitian-symplectic group
HSp(2d) which naturally appears for cocycles related to Schrödinger operators.
In the case d = 1, the formula for HSp(2d) cocycles reduces to the Herman-Avila-Bochi
formula for SL(2, ℝ) cocycles.
author:
- first_name: Christian
full_name: Sadel, Christian
id: 4760E9F8-F248-11E8-B48F-1D18A9856A87
last_name: Sadel
orcid: 0000-0001-8255-3968
citation:
ama: Sadel C. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems.
2015;35(5):1582-1591. doi:10.1017/etds.2013.103
apa: Sadel, C. (2015). A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems.
Cambridge University Press. https://doi.org/10.1017/etds.2013.103
chicago: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional
Pseudo-Unitary and Hermitian-Symplectic-Cocycles.” Ergodic Theory and Dynamical
Systems. Cambridge University Press, 2015. https://doi.org/10.1017/etds.2013.103.
ieee: C. Sadel, “A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles,” Ergodic Theory and Dynamical Systems,
vol. 35, no. 5. Cambridge University Press, pp. 1582–1591, 2015.
ista: Sadel C. 2015. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems. 35(5),
1582–1591.
mla: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional Pseudo-Unitary
and Hermitian-Symplectic-Cocycles.” Ergodic Theory and Dynamical Systems,
vol. 35, no. 5, Cambridge University Press, 2015, pp. 1582–91, doi:10.1017/etds.2013.103.
short: C. Sadel, Ergodic Theory and Dynamical Systems 35 (2015) 1582–1591.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-03-14T00:00:00Z
date_updated: 2021-01-12T06:51:13Z
day: '14'
doi: 10.1017/etds.2013.103
extern: '1'
intvolume: ' 35'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1307.8414
month: '03'
oa: 1
oa_version: Preprint
page: 1582 - 1591
publication: Ergodic Theory and Dynamical Systems
publication_status: published
publisher: Cambridge University Press
publist_id: '5675'
quality_controlled: '1'
status: public
title: A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2015'
...
---
_id: '1510'
abstract:
- lang: eng
text: 'The concept of well group in a special but important case captures homological
properties of the zero set of a continuous map f from K to R^n on a compact space
K that are invariant with respect to perturbations of f. The perturbations are
arbitrary continuous maps within L_infty distance r from f for a given r >
0. The main drawback of the approach is that the computability of well groups
was shown only when dim K = n or n = 1. Our contribution to the theory of well
groups is twofold: on the one hand we improve on the computability issue, but
on the other hand we present a range of examples where the well groups are incomplete
invariants, that is, fail to capture certain important robust properties of the
zero set. For the first part, we identify a computable subgroup of the well group
that is obtained by cap product with the pullback of the orientation of R^n by
f. In other words, well groups can be algorithmically approximated from below.
When f is smooth and dim K < 2n-2, our approximation of the (dim K-n)th well
group is exact. For the second part, we find examples of maps f, f'' from K to
R^n with all well groups isomorphic but whose perturbations have different zero
sets. We discuss on a possible replacement of the well groups of vector valued
maps by an invariant of a better descriptive power and computability status. '
alternative_title:
- LIPIcs
author:
- first_name: Peter
full_name: Franek, Peter
id: 473294AE-F248-11E8-B48F-1D18A9856A87
last_name: Franek
- first_name: Marek
full_name: Krcál, Marek
id: 33E21118-F248-11E8-B48F-1D18A9856A87
last_name: Krcál
citation:
ama: 'Franek P, Krcál M. On computability and triviality of well groups. In: Vol
34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:842-856. doi:10.4230/LIPIcs.SOCG.2015.842'
apa: 'Franek, P., & Krcál, M. (2015). On computability and triviality of well
groups (Vol. 34, pp. 842–856). Presented at the SoCG: Symposium on Computational
Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
https://doi.org/10.4230/LIPIcs.SOCG.2015.842'
chicago: Franek, Peter, and Marek Krcál. “On Computability and Triviality of Well
Groups,” 34:842–56. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. https://doi.org/10.4230/LIPIcs.SOCG.2015.842.
ieee: 'P. Franek and M. Krcál, “On computability and triviality of well groups,”
presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands,
2015, vol. 34, pp. 842–856.'
ista: 'Franek P, Krcál M. 2015. On computability and triviality of well groups.
SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 842–856.'
mla: Franek, Peter, and Marek Krcál. On Computability and Triviality of Well
Groups. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015,
pp. 842–56, doi:10.4230/LIPIcs.SOCG.2015.842.
short: P. Franek, M. Krcál, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2015, pp. 842–856.
conference:
end_date: 2015-06-25
location: Eindhoven, Netherlands
name: 'SoCG: Symposium on Computational Geometry'
start_date: 2015-06-22
date_created: 2018-12-11T11:52:26Z
date_published: 2015-06-11T00:00:00Z
date_updated: 2023-02-21T17:02:57Z
day: '11'
ddc:
- '510'
department:
- _id: UlWa
- _id: HeEd
doi: 10.4230/LIPIcs.SOCG.2015.842
ec_funded: 1
file:
- access_level: open_access
checksum: 49eb5021caafaabe5356c65b9c5f8c9c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:19Z
date_updated: 2020-07-14T12:44:59Z
file_id: '5001'
file_name: IST-2016-503-v1+1_32.pdf
file_size: 623563
relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
intvolume: ' 34'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 842 - 856
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5667'
pubrep_id: '503'
quality_controlled: '1'
related_material:
record:
- id: '1408'
relation: later_version
status: public
scopus_import: 1
status: public
title: On computability and triviality of well groups
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2015'
...
---
_id: '1505'
abstract:
- lang: eng
text: This paper is aimed at deriving the universality of the largest eigenvalue
of a class of high-dimensional real or complex sample covariance matrices of the
form W N =Σ 1/2XX∗Σ 1/2 . Here, X = (xij )M,N is an M× N random matrix with independent
entries xij , 1 ≤ i M,≤ 1 ≤ j ≤ N such that Exij = 0, E|xij |2 = 1/N . On dimensionality,
we assume that M = M(N) and N/M → d ε (0, ∞) as N ∞→. For a class of general deterministic
positive-definite M × M matrices Σ , under some additional assumptions on the
distribution of xij 's, we show that the limiting behavior of the largest eigenvalue
of W N is universal, via pursuing a Green function comparison strategy raised
in [Probab. Theory Related Fields 154 (2012) 341-407, Adv. Math. 229 (2012) 1435-1515]
by Erd″os, Yau and Yin for Wigner matrices and extended by Pillai and Yin [Ann.
Appl. Probab. 24 (2014) 935-1001] to sample covariance matrices in the null case
(&Epsi = I ). Consequently, in the standard complex case (Ex2 ij = 0), combing
this universality property and the results known for Gaussian matrices obtained
by El Karoui in [Ann. Probab. 35 (2007) 663-714] (nonsingular case) and Onatski
in [Ann. Appl. Probab. 18 (2008) 470-490] (singular case), we show that after
an appropriate normalization the largest eigenvalue of W N converges weakly to
the type 2 Tracy-Widom distribution TW2 . Moreover, in the real case, we show
that whenΣ is spiked with a fixed number of subcritical spikes, the type 1 Tracy-Widom
limit TW1 holds for the normalized largest eigenvalue of W N , which extends a
result of Féral and Péché in [J. Math. Phys. 50 (2009) 073302] to the scenario
of nondiagonal Σ and more generally distributed X . In summary, we establish the
Tracy-Widom type universality for the largest eigenvalue of generally distributed
sample covariance matrices under quite light assumptions on &Sigma . Applications
of these limiting results to statistical signal detection and structure recognition
of separable covariance matrices are also discussed.
acknowledgement: "B.Z. was supported in part by NSFC Grant 11071213, ZJNSF
\ Grant R6090034 and SRFDP Grant 20100101110001. P.G. was supported in part
by the Ministry of Education, Singapore, under Grant ARC 14/11. Z.W. was supported
\ in part by the Ministry of Education, Singapore, under Grant ARC 14/11,
\ and by a Grant R-155-000-131-112 at the National University of Singapore\r\n"
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Pan G, Zhou W. Universality for the largest eigenvalue of sample covariance
matrices with general population. Annals of Statistics. 2015;43(1):382-421.
doi:10.1214/14-AOS1281
apa: Bao, Z., Pan, G., & Zhou, W. (2015). Universality for the largest eigenvalue
of sample covariance matrices with general population. Annals of Statistics.
Institute of Mathematical Statistics. https://doi.org/10.1214/14-AOS1281
chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “Universality for the Largest
Eigenvalue of Sample Covariance Matrices with General Population.” Annals of
Statistics. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/14-AOS1281.
ieee: Z. Bao, G. Pan, and W. Zhou, “Universality for the largest eigenvalue of sample
covariance matrices with general population,” Annals of Statistics, vol.
43, no. 1. Institute of Mathematical Statistics, pp. 382–421, 2015.
ista: Bao Z, Pan G, Zhou W. 2015. Universality for the largest eigenvalue of sample
covariance matrices with general population. Annals of Statistics. 43(1), 382–421.
mla: Bao, Zhigang, et al. “Universality for the Largest Eigenvalue of Sample Covariance
Matrices with General Population.” Annals of Statistics, vol. 43, no. 1,
Institute of Mathematical Statistics, 2015, pp. 382–421, doi:10.1214/14-AOS1281.
short: Z. Bao, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 382–421.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-02-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.1214/14-AOS1281
intvolume: ' 43'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1304.5690
month: '02'
oa: 1
oa_version: Preprint
page: 382 - 421
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5672'
quality_controlled: '1'
status: public
title: Universality for the largest eigenvalue of sample covariance matrices with
general population
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1508'
abstract:
- lang: eng
text: We consider generalized Wigner ensembles and general β-ensembles with analytic
potentials for any β ≥ 1. The recent universality results in particular assert
that the local averages of consecutive eigenvalue gaps in the bulk of the spectrum
are universal in the sense that they coincide with those of the corresponding
Gaussian β-ensembles. In this article, we show that local averaging is not necessary
for this result, i.e. we prove that the single gap distributions in the bulk are
universal. In fact, with an additional step, our result can be extended to any
C4(ℝ) potential.
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Gap universality of generalized Wigner and β ensembles. Journal
of the European Mathematical Society. 2015;17(8):1927-2036. doi:10.4171/JEMS/548
apa: Erdös, L., & Yau, H. (2015). Gap universality of generalized Wigner and
β ensembles. Journal of the European Mathematical Society. European Mathematical
Society. https://doi.org/10.4171/JEMS/548
chicago: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and
β Ensembles.” Journal of the European Mathematical Society. European Mathematical
Society, 2015. https://doi.org/10.4171/JEMS/548.
ieee: L. Erdös and H. Yau, “Gap universality of generalized Wigner and β ensembles,”
Journal of the European Mathematical Society, vol. 17, no. 8. European
Mathematical Society, pp. 1927–2036, 2015.
ista: Erdös L, Yau H. 2015. Gap universality of generalized Wigner and β ensembles.
Journal of the European Mathematical Society. 17(8), 1927–2036.
mla: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and β
Ensembles.” Journal of the European Mathematical Society, vol. 17, no.
8, European Mathematical Society, 2015, pp. 1927–2036, doi:10.4171/JEMS/548.
short: L. Erdös, H. Yau, Journal of the European Mathematical Society 17 (2015)
1927–2036.
date_created: 2018-12-11T11:52:26Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:15Z
day: '01'
department:
- _id: LaEr
doi: 10.4171/JEMS/548
intvolume: ' 17'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1211.3786
month: '08'
oa: 1
oa_version: Preprint
page: 1927 - 2036
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society
publist_id: '5669'
quality_controlled: '1'
scopus_import: 1
status: public
title: Gap universality of generalized Wigner and β ensembles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2015'
...
---
_id: '1506'
abstract:
- lang: eng
text: Consider the square random matrix An = (aij)n,n, where {aij:= a(n)ij , i,
j = 1, . . . , n} is a collection of independent real random variables with means
zero and variances one. Under the additional moment condition supn max1≤i,j ≤n
Ea4ij <∞, we prove Girko's logarithmic law of det An in the sense that as n→∞
log | detAn| ? (1/2) log(n-1)! d/→√(1/2) log n N(0, 1).
author:
- first_name: Zhigang
full_name: Bao, Zhigang
id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
last_name: Bao
orcid: 0000-0003-3036-1475
- first_name: Guangming
full_name: Pan, Guangming
last_name: Pan
- first_name: Wang
full_name: Zhou, Wang
last_name: Zhou
citation:
ama: Bao Z, Pan G, Zhou W. The logarithmic law of random determinant. Bernoulli.
2015;21(3):1600-1628. doi:10.3150/14-BEJ615
apa: Bao, Z., Pan, G., & Zhou, W. (2015). The logarithmic law of random determinant.
Bernoulli. Bernoulli Society for Mathematical Statistics and Probability.
https://doi.org/10.3150/14-BEJ615
chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “The Logarithmic Law of Random
Determinant.” Bernoulli. Bernoulli Society for Mathematical Statistics
and Probability, 2015. https://doi.org/10.3150/14-BEJ615.
ieee: Z. Bao, G. Pan, and W. Zhou, “The logarithmic law of random determinant,”
Bernoulli, vol. 21, no. 3. Bernoulli Society for Mathematical Statistics
and Probability, pp. 1600–1628, 2015.
ista: Bao Z, Pan G, Zhou W. 2015. The logarithmic law of random determinant. Bernoulli.
21(3), 1600–1628.
mla: Bao, Zhigang, et al. “The Logarithmic Law of Random Determinant.” Bernoulli,
vol. 21, no. 3, Bernoulli Society for Mathematical Statistics and Probability,
2015, pp. 1600–28, doi:10.3150/14-BEJ615.
short: Z. Bao, G. Pan, W. Zhou, Bernoulli 21 (2015) 1600–1628.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.3150/14-BEJ615
intvolume: ' 21'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1208.5823
month: '08'
oa: 1
oa_version: Preprint
page: 1600 - 1628
publication: Bernoulli
publication_status: published
publisher: Bernoulli Society for Mathematical Statistics and Probability
publist_id: '5671'
quality_controlled: '1'
status: public
title: The logarithmic law of random determinant
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2015'
...
---
_id: '1513'
abstract:
- lang: eng
text: "Insects of the order Hemiptera (true bugs) use a wide range of mechanisms
of sex determination, including genetic sex determination, paternal genome elimination,
and haplodiploidy. Genetic sex determination, the prevalent mode, is generally
controlled by a pair of XY sex chromosomes or by an XX/X0 system, but different
configurations that include additional sex chromosomes are also present. Although
this diversity of sex determining systems has been extensively studied at the
cytogenetic level, only the X chromosome of the model pea aphid Acyrthosiphon
pisum has been analyzed at the genomic level, and little is known about X chromosome
biology in the rest of the order.\r\n\r\nIn this study, we take advantage of published
DNA- and RNA-seq data from three additional Hemiptera species to perform a comparative
analysis of the gene content and expression of the X chromosome throughout this
clade. We find that, despite showing evidence of dosage compensation, the X chromosomes
of these species show female-biased expression, and a deficit of male-biased genes,
in direct contrast to the pea aphid X. We further detect an excess of shared gene
content between these very distant species, suggesting that despite the diversity
of sex determining systems, the same chromosomal element is used as the X throughout
a large portion of the order. "
article_processing_charge: No
author:
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Pal A, Vicoso B. The X chromosome of hemipteran insects: Conservation, dosage
compensation and sex-biased expression. Genome Biology and Evolution. 2015;7(12):3259-3268.
doi:10.1093/gbe/evv215'
apa: 'Pal, A., & Vicoso, B. (2015). The X chromosome of hemipteran insects:
Conservation, dosage compensation and sex-biased expression. Genome Biology
and Evolution. Oxford University Press. https://doi.org/10.1093/gbe/evv215'
chicago: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects:
Conservation, Dosage Compensation and Sex-Biased Expression.” Genome Biology
and Evolution. Oxford University Press, 2015. https://doi.org/10.1093/gbe/evv215.'
ieee: 'A. Pal and B. Vicoso, “The X chromosome of hemipteran insects: Conservation,
dosage compensation and sex-biased expression,” Genome Biology and Evolution,
vol. 7, no. 12. Oxford University Press, pp. 3259–3268, 2015.'
ista: 'Pal A, Vicoso B. 2015. The X chromosome of hemipteran insects: Conservation,
dosage compensation and sex-biased expression. Genome Biology and Evolution. 7(12),
3259–3268.'
mla: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects: Conservation,
Dosage Compensation and Sex-Biased Expression.” Genome Biology and Evolution,
vol. 7, no. 12, Oxford University Press, 2015, pp. 3259–68, doi:10.1093/gbe/evv215.'
short: A. Pal, B. Vicoso, Genome Biology and Evolution 7 (2015) 3259–3268.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evv215
ec_funded: 1
file:
- access_level: open_access
checksum: 2b56b8c2e2a1d4cc3c9cb8daba26dd9b
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:29Z
date_updated: 2020-07-14T12:45:00Z
file_id: '5284'
file_name: IST-2016-496-v1+1_Genome_Biol_Evol-2015-Pal-3259-68.pdf
file_size: 858027
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 3259 - 3268
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '5664'
pubrep_id: '496'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'The X chromosome of hemipteran insects: Conservation, dosage compensation
and sex-biased expression'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
_id: '1517'
abstract:
- lang: eng
text: "We study the large deviation rate functional for the empirical distribution
of independent Brownian particles with drift. In one dimension, it has been shown
by Adams, Dirr, Peletier and Zimmer that this functional is asymptotically equivalent
(in the sense of Γ-convergence) to the Jordan-Kinderlehrer-Otto functional arising
in the Wasserstein gradient flow structure of the Fokker-Planck equation. In higher
dimensions, part of this statement (the lower bound) has been recently proved
by Duong, Laschos and Renger, but the upper bound remained open, since the proof
of Duong et al relies on regularity properties of optimal transport maps that
are restricted to one dimension. In this note we present a new proof of the upper
bound, thereby generalising the result of Adams et al to arbitrary dimensions.\r\n"
article_number: '89'
author:
- first_name: Matthias
full_name: Erbar, Matthias
last_name: Erbar
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Michiel
full_name: Renger, Michiel
last_name: Renger
citation:
ama: Erbar M, Maas J, Renger M. From large deviations to Wasserstein gradient flows
in multiple dimensions. Electronic Communications in Probability. 2015;20.
doi:10.1214/ECP.v20-4315
apa: Erbar, M., Maas, J., & Renger, M. (2015). From large deviations to Wasserstein
gradient flows in multiple dimensions. Electronic Communications in Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/ECP.v20-4315
chicago: Erbar, Matthias, Jan Maas, and Michiel Renger. “From Large Deviations to
Wasserstein Gradient Flows in Multiple Dimensions.” Electronic Communications
in Probability. Institute of Mathematical Statistics, 2015. https://doi.org/10.1214/ECP.v20-4315.
ieee: M. Erbar, J. Maas, and M. Renger, “From large deviations to Wasserstein gradient
flows in multiple dimensions,” Electronic Communications in Probability,
vol. 20. Institute of Mathematical Statistics, 2015.
ista: Erbar M, Maas J, Renger M. 2015. From large deviations to Wasserstein gradient
flows in multiple dimensions. Electronic Communications in Probability. 20, 89.
mla: Erbar, Matthias, et al. “From Large Deviations to Wasserstein Gradient Flows
in Multiple Dimensions.” Electronic Communications in Probability, vol.
20, 89, Institute of Mathematical Statistics, 2015, doi:10.1214/ECP.v20-4315.
short: M. Erbar, J. Maas, M. Renger, Electronic Communications in Probability 20
(2015).
date_created: 2018-12-11T11:52:29Z
date_published: 2015-11-29T00:00:00Z
date_updated: 2021-01-12T06:51:19Z
day: '29'
ddc:
- '519'
department:
- _id: JaMa
doi: 10.1214/ECP.v20-4315
file:
- access_level: open_access
checksum: 135741c17d3e1547ca696b6fbdcd559c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:39Z
date_updated: 2020-07-14T12:45:00Z
file_id: '4828'
file_name: IST-2016-494-v1+1_4315-23820-1-PB.pdf
file_size: 230525
relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: ' 20'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Electronic Communications in Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5660'
pubrep_id: '494'
quality_controlled: '1'
scopus_import: 1
status: public
title: From large deviations to Wasserstein gradient flows in multiple dimensions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2015'
...
---
_id: '1515'
abstract:
- lang: eng
text: Type 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in different
forms of synaptic plasticity in the cerebellar cortex, e.g. long-term depression
at glutamatergic synapses and rebound potentiation at GABAergic synapses. These
various forms of plasticity might depend on the subsynaptic arrangement of the
receptor in Purkinje cells that can be regulated by protein-protein interactions.
This study investigated, by means of the freeze-fracture replica immunogold labelling
method, the subcellular localization of mGlu1 receptors in the rodent cerebellum
and whether Homer proteins regulate their subsynaptic distribution. We observed
a widespread extrasynaptic localization of mGlu1 receptors and confirmed their
peri-synaptic enrichment at glutamatergic synapses. Conversely, we detected mGlu1
receptors within the main body of GABAergic synapses onto Purkinje cell dendrites.
Although Homer proteins are known to interact with the mGlu1 receptor C-terminus,
we could not detect Homer3, the most abundant Homer protein in the cerebellar
cortex, at GABAergic synapses by pre-embedding and post-embedding immunoelectron
microscopy. We then hypothesized a critical role for Homer proteins in the peri-junctional
localization of mGlu1 receptors at glutamatergic synapses. To disrupt Homer-associated
protein complexes, mice were tail-vein injected with the membrane-permeable dominant-negative
TAT-Homer1a. Freeze-fracture replica immunogold labelling analysis showed no significant
alteration in the mGlu1 receptor distribution pattern at parallel fibre-Purkinje
cell synapses, suggesting that other scaffolding proteins are involved in the
peri-synaptic confinement. The identification of interactors that regulate the
subsynaptic localization of the mGlu1 receptor at neurochemically distinct synapses
may offer new insight into its trafficking and intracellular signalling.
acknowledgement: This work was supported by the Austrian Science Fund (FWF) (project
W012060-10 to F.F.), The Japan Society for the Promotion of Science (JSPS) (to R.S.)
and Agence Nationale de la Recherche (ANR-11-BSV4-018-03, DELTAPLAN), Région Languedoc-Roussillon
(Chercheur d’Avenir) (to J.P.). The authors thank S. Schönherr for excellent technical
support and Dr Furuichi for kindly providing anti-Homer3 antibodies.
author:
- first_name: Mahnaz
full_name: Mansouri, Mahnaz
last_name: Mansouri
- first_name: Yu
full_name: Kasugai, Yu
last_name: Kasugai
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Federica
full_name: Bertaso, Federica
last_name: Bertaso
- first_name: Fabrice
full_name: Raynaud, Fabrice
last_name: Raynaud
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
- first_name: Walter
full_name: Walter Kaufmann
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Mansouri M, Kasugai Y, Fukazawa Y, et al. Distinct subsynaptic localization
of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
in the rodent cerebellar cortex. European Journal of Neuroscience. 2015;41(2):157-167.
doi:10.1111/ejn.12779
apa: Mansouri, M., Kasugai, Y., Fukazawa, Y., Bertaso, F., Raynaud, F., Perroy,
J., … Ferraguti, F. (2015). Distinct subsynaptic localization of type 1 metabotropic
glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
cortex. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/ejn.12779
chicago: Mansouri, Mahnaz, Yu Kasugai, Yugo Fukazawa, Federica Bertaso, Fabrice
Raynaud, Julie Perroy, Laurent Fagni, et al. “Distinct Subsynaptic Localization
of Type 1 Metabotropic Glutamate Receptors at Glutamatergic and GABAergic Synapses
in the Rodent Cerebellar Cortex.” European Journal of Neuroscience. Wiley-Blackwell,
2015. https://doi.org/10.1111/ejn.12779.
ieee: M. Mansouri et al., “Distinct subsynaptic localization of type 1 metabotropic
glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
cortex,” European Journal of Neuroscience, vol. 41, no. 2. Wiley-Blackwell,
pp. 157–167, 2015.
ista: Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, Fagni L,
Kaufmann W, Watanabe M, Shigemoto R, Ferraguti F. 2015. Distinct subsynaptic localization
of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
in the rodent cerebellar cortex. European Journal of Neuroscience. 41(2), 157–167.
mla: Mansouri, Mahnaz, et al. “Distinct Subsynaptic Localization of Type 1 Metabotropic
Glutamate Receptors at Glutamatergic and GABAergic Synapses in the Rodent Cerebellar
Cortex.” European Journal of Neuroscience, vol. 41, no. 2, Wiley-Blackwell,
2015, pp. 157–67, doi:10.1111/ejn.12779.
short: M. Mansouri, Y. Kasugai, Y. Fukazawa, F. Bertaso, F. Raynaud, J. Perroy,
L. Fagni, W. Kaufmann, M. Watanabe, R. Shigemoto, F. Ferraguti, European Journal
of Neuroscience 41 (2015) 157–167.
date_created: 2018-12-11T11:52:28Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-23T10:02:24Z
day: '01'
doi: 10.1111/ejn.12779
extern: 1
intvolume: ' 41'
issue: '2'
month: '01'
page: 157 - 167
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5662'
quality_controlled: 0
status: public
title: Distinct subsynaptic localization of type 1 metabotropic glutamate receptors
at glutamatergic and GABAergic synapses in the rodent cerebellar cortex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 41
year: '2015'
...
---
_id: '1514'
abstract:
- lang: eng
text: 'Endocannabinoids (eCBs) play key roles in brain function, acting as modulatory
signals in synaptic transmission and plasticity. They are recognized as retrograde
messengers that mediate long-term synaptic depression (LTD), but their ability
to induce long-term potentiation (LTP) is poorly known. We show that eCBs induce
the long-term enhancement of transmitter release at single hippocampal synapses
through stimulation of astrocytes when coincident with postsynaptic activity.
This LTP requires the coordinated activity of the 3 elements of the tripartite
synapse: 1) eCB-evoked astrocyte calcium signal that stimulates glutamate release;
2) postsynaptic nitric oxide production; and 3) activation of protein kinase C
and presynaptic group I metabotropic glutamate receptors, whose location at presynaptic
sites was confirmed by immunoelectron microscopy. Hence, while eCBs act as retrograde
signals to depress homoneuronal synapses, they serve as lateral messengers to
induce LTP in distant heteroneuronal synapses through stimulation of astrocytes.
Therefore, eCBs can trigger LTP through stimulation of astrocyte-neuron signaling,
revealing novel cellular mechanisms of eCB effects on synaptic plasticity.'
acknowledgement: |-
This work was supported by grants from Ministerio de Economia y Competitividad, Spain (MINECO; BFU2010-15832), European Union (HEALTH-F2-2007-202167), and Cajal Blue Brain to A.A. Grants from Spain (MINECO; BFU-2009-08404 and
CSD2008-00005) to R.L. Grants from Spain (MINECO; Consolider, CSD2010-00045; Ramón y Cajal Program, RYC-2012-12014; and BFU2013-47265) to G.P. We thank Dr Atsu Aiba (Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo) for the donation of the mGluR1b rescue mice.
author:
- first_name: Marta
full_name: Gómez-Gonzalo, Marta
last_name: Gómez Gonzalo
- first_name: Marta
full_name: Navarrete, Marta
last_name: Navarrete
- first_name: Gertrudis
full_name: Perea, Gertrudis
last_name: Perea
- first_name: Ana
full_name: Covelo, Ana
last_name: Covelo
- first_name: Mario
full_name: Martín-Fernández, Mario
last_name: Martín Fernández
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Alfonso
full_name: Araque, Alfonso
last_name: Araque
citation:
ama: Gómez Gonzalo M, Navarrete M, Perea G, et al. Endocannabinoids induce lateral
long term potentiation of transmitter release by stimulation of gliotransmission.
Cerebral Cortex. 2015;25(10):3699-3712. doi:10.1093/cercor/bhu231
apa: Gómez Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín Fernández,
M., Shigemoto, R., … Araque, A. (2015). Endocannabinoids induce lateral long term
potentiation of transmitter release by stimulation of gliotransmission. Cerebral
Cortex. Oxford University Press. https://doi.org/10.1093/cercor/bhu231
chicago: Gómez Gonzalo, Marta, Marta Navarrete, Gertrudis Perea, Ana Covelo, Mario
Martín Fernández, Ryuichi Shigemoto, Rafael Luján, and Alfonso Araque. “Endocannabinoids
Induce Lateral Long Term Potentiation of Transmitter Release by Stimulation of
Gliotransmission.” Cerebral Cortex. Oxford University Press, 2015. https://doi.org/10.1093/cercor/bhu231.
ieee: M. Gómez Gonzalo et al., “Endocannabinoids induce lateral long term
potentiation of transmitter release by stimulation of gliotransmission,” Cerebral
Cortex, vol. 25, no. 10. Oxford University Press, pp. 3699–3712, 2015.
ista: Gómez Gonzalo M, Navarrete M, Perea G, Covelo A, Martín Fernández M, Shigemoto
R, Luján R, Araque A. 2015. Endocannabinoids induce lateral long term potentiation
of transmitter release by stimulation of gliotransmission. Cerebral Cortex. 25(10),
3699–3712.
mla: Gómez Gonzalo, Marta, et al. “Endocannabinoids Induce Lateral Long Term Potentiation
of Transmitter Release by Stimulation of Gliotransmission.” Cerebral Cortex,
vol. 25, no. 10, Oxford University Press, 2015, pp. 3699–712, doi:10.1093/cercor/bhu231.
short: M. Gómez Gonzalo, M. Navarrete, G. Perea, A. Covelo, M. Martín Fernández,
R. Shigemoto, R. Luján, A. Araque, Cerebral Cortex 25 (2015) 3699–3712.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-10-10T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '10'
doi: 10.1093/cercor/bhu231
extern: 1
intvolume: ' 25'
issue: '10'
month: '10'
page: 3699 - 3712
publication: Cerebral Cortex
publication_status: published
publisher: Oxford University Press
publist_id: '5663'
quality_controlled: 0
status: public
title: Endocannabinoids induce lateral long term potentiation of transmitter release
by stimulation of gliotransmission
type: journal_article
volume: 25
year: '2015'
...