--- _id: '3289' abstract: - lang: eng text: "Viral manipulation of transduction pathways associated with key cellular functions such as survival, response to microbial infection, and cytoskeleton reorganization can provide the supportive milieu for a productive infection. Here, we demonstrate that vaccinia virus (VACV) infection leads to activation of the stress-activated protein kinase (SAPK)/extracellular signal-regulated kinase (ERK) 4/7 (MKK4/7)-c-Jun N-terminal protein kinase 1/2 (JNK1/2) pathway; further, the stimulation of this pathway requires postpenetration, prereplicative events in the viral replication cycle. Although the formation of intracellular mature virus (IMV) was not affected in MKK4/7- or JNK1/2-knockout (KO) cells, we did note an accentuated deregulation of microtubule and actin network organization in infected JNK1/2-KO cells. This was followed by deregulated viral trafficking to the periphery and enhanced enveloped particle release. Furthermore, VACV infection induced alterations in the cell contractility and morphology, and cell migration was reduced in the JNK-KO cells. In addition, phosphorylation of proteins implicated with early cell contractility and cell migration, such as microtubule-associated protein 1B and paxillin, respectively, was not detected in the VACV-infected KO cells. In sum, our findings uncover a regulatory role played by the MKK4/7-JNK1/2 pathway in cytoskeleton reorganization during VACV infection.\r\n" acknowledgement: "This work was supported by grants from Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), the Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES), and the National Council for Scientific and Technological Development (CNPq). A.C.T.C.P., B.S.A.F.B., F.G.G.L., and J.A.P.S.-M. were recipients of predoctoral fellowships from CNPq. C.A.B., E.G.K., T.S.-P., P.F.P.P., and P.C.P.F. are recipients of research fellowships from CNPq. \r\n\r\n\r\nWe are grateful to Angela S. Lopes, Ilda M. V. Gama, João R. dos Santos, and Andreza A. Carvalho for their secretarial/technical assistance and to Fernanda Gambogi for help with immunofluorescence microscopy. We also thank M. C. Sogayar (Department of Biochemistry, University of São Paulo, São Paulo, Brazil), who kindly provided us with the A31 cell line, and R. Davis (Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA) for the WT and JNK1/2-, MKK4-, MKK7-, and MKK4/7-KO cells. VACV WR was from C. Jungwirth (Universität Würzburg, Würzburg, Germany). The recombinant VACV vF13L-GFP and the rabbit polyclonal antibodies against viral proteins, B5R, D8L, L1R, and A36R, were from B. Moss (NIAID, Bethesda, MD). The pcDNA3-Myc-JNK2-MKK7 WT plasmid was from Eugen Kerkhoff (Universität Würzburg, Würzburg, Germany). We also thank Flávio G. da Fonseca (UFMG, Belo Horizonte, MG, Brazil) and Kathleen A. Boyle (Medical College of Wisconsin, Milwaukee, WI) for critically reading the manuscript." author: - first_name: Anna full_name: Pereira, Anna last_name: Pereira - first_name: Flávia full_name: Leite, Flávia id: 36705F98-F248-11E8-B48F-1D18A9856A87 last_name: Leite - first_name: Bruno full_name: Brasil, Bruno last_name: Brasil - first_name: Jamaria full_name: Soares Martins, Jamaria last_name: Soares Martins - first_name: Alice full_name: Torres, Alice last_name: Torres - first_name: Paulo full_name: Pimenta, Paulo last_name: Pimenta - first_name: Thais full_name: Souto Padrón, Thais last_name: Souto Padrón - first_name: Paula full_name: Tranktman, Paula last_name: Tranktman - first_name: Paulo full_name: Ferreira, Paulo last_name: Ferreira - first_name: Erna full_name: Kroon, Erna last_name: Kroon - first_name: Cláudio full_name: Bonjardim, Cláudio last_name: Bonjardim citation: ama: Pereira A, Leite F, Brasil B, et al. A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. Journal of Virology. 2012;86(1):172-184. doi:10.1128/JVI.05638-11 apa: Pereira, A., Leite, F., Brasil, B., Soares Martins, J., Torres, A., Pimenta, P., … Bonjardim, C. (2012). A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. Journal of Virology. ASM. https://doi.org/10.1128/JVI.05638-11 chicago: Pereira, Anna, Flávia Leite, Bruno Brasil, Jamaria Soares Martins, Alice Torres, Paulo Pimenta, Thais Souto Padrón, et al. “A Vaccinia Virus-Driven Interplay between the MKK4/7-JNK1/2 Pathway and Cytoskeleton Reorganization.” Journal of Virology. ASM, 2012. https://doi.org/10.1128/JVI.05638-11. ieee: A. Pereira et al., “A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization,” Journal of Virology, vol. 86, no. 1. ASM, pp. 172–184, 2012. ista: Pereira A, Leite F, Brasil B, Soares Martins J, Torres A, Pimenta P, Souto Padrón T, Tranktman P, Ferreira P, Kroon E, Bonjardim C. 2012. A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. Journal of Virology. 86(1), 172–184. mla: Pereira, Anna, et al. “A Vaccinia Virus-Driven Interplay between the MKK4/7-JNK1/2 Pathway and Cytoskeleton Reorganization.” Journal of Virology, vol. 86, no. 1, ASM, 2012, pp. 172–84, doi:10.1128/JVI.05638-11. short: A. Pereira, F. Leite, B. Brasil, J. Soares Martins, A. Torres, P. Pimenta, T. Souto Padrón, P. Tranktman, P. Ferreira, E. Kroon, C. Bonjardim, Journal of Virology 86 (2012) 172–184. date_created: 2018-12-11T12:02:29Z date_published: 2012-01-01T00:00:00Z date_updated: 2021-01-12T07:42:25Z day: '01' department: - _id: JoBo doi: 10.1128/JVI.05638-11 external_id: pmid: - '22031940' intvolume: ' 86' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255887/ month: '01' oa: 1 oa_version: Submitted Version page: 172 - 184 pmid: 1 publication: Journal of Virology publication_status: published publisher: ASM publist_id: '3356' quality_controlled: '1' scopus_import: 1 status: public title: A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2012' ... --- _id: '3310' abstract: - lang: eng text: The theory of persistent homology opens up the possibility to reason about topological features of a space or a function quantitatively and in combinatorial terms. We refer to this new angle at a classical subject within algebraic topology as a point calculus, which we present for the family of interlevel sets of a real-valued function. Our account of the subject is expository, devoid of proofs, and written for non-experts in algebraic topology. acknowledgement: Research by the third author is partially supported by the National Science Foundation (NSF) under grant DBI-0820624. author: - first_name: Paul full_name: Bendich, Paul id: 43F6EC54-F248-11E8-B48F-1D18A9856A87 last_name: Bendich - first_name: Sergio full_name: Cabello, Sergio last_name: Cabello - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Bendich P, Cabello S, Edelsbrunner H. A point calculus for interlevel set homology. Pattern Recognition Letters. 2012;33(11):1436-1444. doi:10.1016/j.patrec.2011.10.007 apa: Bendich, P., Cabello, S., & Edelsbrunner, H. (2012). A point calculus for interlevel set homology. Pattern Recognition Letters. Elsevier. https://doi.org/10.1016/j.patrec.2011.10.007 chicago: Bendich, Paul, Sergio Cabello, and Herbert Edelsbrunner. “A Point Calculus for Interlevel Set Homology.” Pattern Recognition Letters. Elsevier, 2012. https://doi.org/10.1016/j.patrec.2011.10.007. ieee: P. Bendich, S. Cabello, and H. Edelsbrunner, “A point calculus for interlevel set homology,” Pattern Recognition Letters, vol. 33, no. 11. Elsevier, pp. 1436–1444, 2012. ista: Bendich P, Cabello S, Edelsbrunner H. 2012. A point calculus for interlevel set homology. Pattern Recognition Letters. 33(11), 1436–1444. mla: Bendich, Paul, et al. “A Point Calculus for Interlevel Set Homology.” Pattern Recognition Letters, vol. 33, no. 11, Elsevier, 2012, pp. 1436–44, doi:10.1016/j.patrec.2011.10.007. short: P. Bendich, S. Cabello, H. Edelsbrunner, Pattern Recognition Letters 33 (2012) 1436–1444. date_created: 2018-12-11T12:02:36Z date_published: 2012-08-01T00:00:00Z date_updated: 2021-01-12T07:42:34Z day: '01' ddc: - '000' department: - _id: HeEd doi: 10.1016/j.patrec.2011.10.007 file: - access_level: open_access checksum: d65f79775b51258a604ca5ec741297cc content_type: application/pdf creator: system date_created: 2018-12-12T10:15:00Z date_updated: 2020-07-14T12:46:06Z file_id: '5116' file_name: IST-2016-542-v1+1_2012-J-01-Poinculus.pdf file_size: 280280 relation: main_file file_date_updated: 2020-07-14T12:46:06Z has_accepted_license: '1' intvolume: ' 33' issue: '11' language: - iso: eng month: '08' oa: 1 oa_version: Submitted Version page: 1436 - 1444 publication: Pattern Recognition Letters publication_status: published publisher: Elsevier publist_id: '3330' pubrep_id: '542' quality_controlled: '1' scopus_import: 1 status: public title: A point calculus for interlevel set homology type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 33 year: '2012' ... --- _id: '338' abstract: - lang: eng text: The ample chemical and structural freedom of quaternary compounds permits engineering materials that fulfill the requirements of a wide variety of applications. In this work, the mechanisms to achieve unprecedented size, shape, and composition control in quaternary nanocrystals are detailed. The described procedure allows obtaining tetrahedral and penta-tetrahedral quaternary nanocrystals with tuned size distributions and controlled compositions from a plethora of I 2-II-IV-VI 4 semiconductors. acknowledgement: "This work was supported by the Spanish MICINN Projects MAT2008-05779, MAT2008-03400-E/MAT, MAT2010-15138, ENE2008-03277-E/CON, CSD2009-00050, and CSD2009-00013. M.I. thanks the Spanish MICINN for her Ph.D. grant. J.A. and R.Z. also acknowledge Generalitat de Catalunya 2009-SGR-770 and XaRMAE. A.C. is grateful for financial support through the Ramon y Cajal program of the Spanish MICINN.\r\n\r\n" article_processing_charge: No article_type: original author: - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Reza full_name: Zamani, Reza last_name: Zamani - first_name: Wenhua full_name: Li, Wenhua last_name: Li - first_name: Alexey full_name: Shavel, Alexey last_name: Shavel - first_name: Jordi full_name: Arbiol, Jordi last_name: Arbiol - first_name: Joan full_name: Morante, Joan last_name: Morante - first_name: Andreu full_name: Cabot, Andreu last_name: Cabot citation: ama: Ibáñez M, Zamani R, Li W, et al. Extending the nanocrystal synthesis control to quaternary compositions. Crystal Growth and Design . 2012;12(3):1085-1090. doi:10.1021/cg201709c apa: Ibáñez, M., Zamani, R., Li, W., Shavel, A., Arbiol, J., Morante, J., & Cabot, A. (2012). Extending the nanocrystal synthesis control to quaternary compositions. Crystal Growth and Design . American Chemical Society (ACS). https://doi.org/10.1021/cg201709c chicago: Ibáñez, Maria, Reza Zamani, Wenhua Li, Alexey Shavel, Jordi Arbiol, Joan Morante, and Andreu Cabot. “Extending the Nanocrystal Synthesis Control to Quaternary Compositions.” Crystal Growth and Design . American Chemical Society (ACS), 2012. https://doi.org/10.1021/cg201709c. ieee: M. Ibáñez et al., “Extending the nanocrystal synthesis control to quaternary compositions,” Crystal Growth and Design , vol. 12, no. 3. American Chemical Society (ACS), pp. 1085–1090, 2012. ista: Ibáñez M, Zamani R, Li W, Shavel A, Arbiol J, Morante J, Cabot A. 2012. Extending the nanocrystal synthesis control to quaternary compositions. Crystal Growth and Design . 12(3), 1085–1090. mla: Ibáñez, Maria, et al. “Extending the Nanocrystal Synthesis Control to Quaternary Compositions.” Crystal Growth and Design , vol. 12, no. 3, American Chemical Society (ACS), 2012, pp. 1085–90, doi:10.1021/cg201709c. short: M. Ibáñez, R. Zamani, W. Li, A. Shavel, J. Arbiol, J. Morante, A. Cabot, Crystal Growth and Design 12 (2012) 1085–1090. date_created: 2018-12-11T11:45:54Z date_published: 2012-01-01T00:00:00Z date_updated: 2021-01-12T07:43:05Z day: '01' doi: 10.1021/cg201709c extern: '1' intvolume: ' 12' issue: '3' language: - iso: eng month: '01' oa_version: None page: 1085 - 1090 publication: 'Crystal Growth and Design ' publication_status: published publisher: American Chemical Society (ACS) publist_id: '7488' quality_controlled: '1' status: public title: Extending the nanocrystal synthesis control to quaternary compositions type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2012' ... --- _id: '339' abstract: - lang: eng text: A high-yield and upscalable colloidal synthesis route for the production of quaternary I 2-II-IV-VI 4 nanocrystals, particularly stannite Cu 2+xCd 1-xSnSe 4, with narrow size distribution and precisely controlled composition is presented. It is also shown here how the diversity of valences in the constituent elements allows an effective control of their electrical conductivity through the adjustment of the cation ratios. At the same time, while the crystallographic complexity of quaternary chalcogenides is associated with intrinsically low thermal conductivities, the reduction of the lattice dimensions to the nanoscale further reduces the materials thermal conductivity. In the specific case of the stannite crystal structure, a convenient slab distribution of the valence band maximum states permits a partial decoupling of the p-type electrical conductivity from both the Seebeck coefficient and the thermal conductivity. Combining these features, we demonstrate how an initial optimization of the nanocrystals Cd/Cu ratio allowed us to obtain low-temperature solution-processed materials with ZT values up to 0.71 at 685 K. acknowledgement: This work was supported by the Spanish MICINN Projects MAT2008-05779, MAT2008-03400-E/MAT, MAT2010-15138, ENE2008-03277-E/CON, CSD2009-00050. and CSD2009-00013. M.I. and N.G.-C. thank the Spanish MICINN for the PhD grant. J.A. and R.Z. also acknowledge Generalitat de Catalunya 2009-SGR-770 and XaRMAE. A.C. is thankful for financial support through the Ramon y Cajal program of the Spanish MICINN. N.G.-C. and J.D.P. are thankful for the computer resources, technical expertise and assistance provided by the Barcelona Supercomputing Center - Centro Nacional de Supercomputación. article_processing_charge: No article_type: original author: - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Doris full_name: Cadavid, Doris last_name: Cadavid - first_name: Reza full_name: Zamani, Reza last_name: Zamani - first_name: Nuria full_name: García Castelló, Nuria last_name: García Castelló - first_name: Victora full_name: Izquierdo Roca, Victora last_name: Izquierdo Roca - first_name: Wenhua full_name: Li, Wenhua last_name: Li - first_name: Andrew full_name: Fairbrother, Andrew last_name: Fairbrother - first_name: Joan full_name: Prades, Joan last_name: Prades - first_name: Alexey full_name: Shavel, Alexey last_name: Shavel - first_name: Jordi full_name: Arbiol, Jordi last_name: Arbiol - first_name: Alejandro full_name: Pérez Rodríguez, Alejandro last_name: Pérez Rodríguez - first_name: Joan full_name: Morante, Joan last_name: Morante - first_name: Andreu full_name: Cabot, Andreu last_name: Cabot citation: ama: 'Ibáñez M, Cadavid D, Zamani R, et al. Composition control and thermoelectric properties of quaternary chalcogenide nanocrystals: The case of stannite Cu2CdSnSe4. Chemistry of Materials. 2012;24(3):562-570. doi:10.1021/cm2031812' apa: 'Ibáñez, M., Cadavid, D., Zamani, R., García Castelló, N., Izquierdo Roca, V., Li, W., … Cabot, A. (2012). Composition control and thermoelectric properties of quaternary chalcogenide nanocrystals: The case of stannite Cu2CdSnSe4. Chemistry of Materials. American Chemical Society. https://doi.org/10.1021/cm2031812' chicago: 'Ibáñez, Maria, Doris Cadavid, Reza Zamani, Nuria García Castelló, Victora Izquierdo Roca, Wenhua Li, Andrew Fairbrother, et al. “Composition Control and Thermoelectric Properties of Quaternary Chalcogenide Nanocrystals: The Case of Stannite Cu2CdSnSe4.” Chemistry of Materials. American Chemical Society, 2012. https://doi.org/10.1021/cm2031812.' ieee: 'M. Ibáñez et al., “Composition control and thermoelectric properties of quaternary chalcogenide nanocrystals: The case of stannite Cu2CdSnSe4,” Chemistry of Materials, vol. 24, no. 3. American Chemical Society, pp. 562–570, 2012.' ista: 'Ibáñez M, Cadavid D, Zamani R, García Castelló N, Izquierdo Roca V, Li W, Fairbrother A, Prades J, Shavel A, Arbiol J, Pérez Rodríguez A, Morante J, Cabot A. 2012. Composition control and thermoelectric properties of quaternary chalcogenide nanocrystals: The case of stannite Cu2CdSnSe4. Chemistry of Materials. 24(3), 562–570.' mla: 'Ibáñez, Maria, et al. “Composition Control and Thermoelectric Properties of Quaternary Chalcogenide Nanocrystals: The Case of Stannite Cu2CdSnSe4.” Chemistry of Materials, vol. 24, no. 3, American Chemical Society, 2012, pp. 562–70, doi:10.1021/cm2031812.' short: M. Ibáñez, D. Cadavid, R. Zamani, N. García Castelló, V. Izquierdo Roca, W. Li, A. Fairbrother, J. Prades, A. Shavel, J. Arbiol, A. Pérez Rodríguez, J. Morante, A. Cabot, Chemistry of Materials 24 (2012) 562–570. date_created: 2018-12-11T11:45:54Z date_published: 2012-01-31T00:00:00Z date_updated: 2021-01-12T07:43:09Z day: '31' doi: 10.1021/cm2031812 extern: '1' intvolume: ' 24' issue: '3' language: - iso: eng month: '01' oa_version: None page: 562 - 570 publication: Chemistry of Materials publication_status: published publisher: American Chemical Society publist_id: '7489' quality_controlled: '1' status: public title: 'Composition control and thermoelectric properties of quaternary chalcogenide nanocrystals: The case of stannite Cu2CdSnSe4' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 24 year: '2012' ... --- _id: '340' abstract: - lang: eng text: 'A procedure for the continuous production of Cu 2ZnSnS 4 (CZTS) nanoparticles with controlled composition is presented. CZTS nanoparticles were prepared through the reaction of the metals'' amino complexes with elemental sulfur in a continuous-flow reactor at moderate temperatures (300-330 °C). High-resolution transmission electron microscopy and X-ray diffraction analysis showed the nanocrystals to have a crystallographic structure compatible with that of the kesterite. Chemical characterization of the materials showed the presence of the four elements in each individual nanocrystal. Composition control was achieved by adjusting the solution flow rate through the reactor and the proper choice of the nominal precursor concentration within the flowing solution. Single-particle analysis revealed a composition distribution within each sample, which was optimized at the highest synthesis temperatures used. ' acknowledgement: This work was supported by the Spanish MICINN Projects MAT2008-05779, MAT2008-03400-E/MAT, CDS2009-00050, CSD2009-00013, and ENE2008-03277-E/CON. M.I. thanks the Spanish MICINN for her Ph.D. grant. A.C. is thankful for financial support through the Ramón y Cajal Program. article_processing_charge: No article_type: original author: - first_name: Alexey full_name: Shavel, Alexey last_name: Shavel - first_name: Doris full_name: Cadavid, Doris last_name: Cadavid - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Alex full_name: Carrete, Alex last_name: Carrete - first_name: Andreu full_name: Cabot, Andreu last_name: Cabot citation: ama: Shavel A, Cadavid D, Ibáñez M, Carrete A, Cabot A. Continuous production of Cu inf 2 inf ZnSnS inf 4 inf nanocrystals in a flow reactor. Journal of the American Chemical Society. 2012;134(3):1438-1441. doi:10.1021/ja209688a apa: Shavel, A., Cadavid, D., Ibáñez, M., Carrete, A., & Cabot, A. (2012). Continuous production of Cu inf 2 inf ZnSnS inf 4 inf nanocrystals in a flow reactor. Journal of the American Chemical Society. ACS. https://doi.org/10.1021/ja209688a chicago: Shavel, Alexey, Doris Cadavid, Maria Ibáñez, Alex Carrete, and Andreu Cabot. “Continuous Production of Cu Inf 2 Inf ZnSnS Inf 4 Inf Nanocrystals in a Flow Reactor.” Journal of the American Chemical Society. ACS, 2012. https://doi.org/10.1021/ja209688a. ieee: A. Shavel, D. Cadavid, M. Ibáñez, A. Carrete, and A. Cabot, “Continuous production of Cu inf 2 inf ZnSnS inf 4 inf nanocrystals in a flow reactor,” Journal of the American Chemical Society, vol. 134, no. 3. ACS, pp. 1438–1441, 2012. ista: Shavel A, Cadavid D, Ibáñez M, Carrete A, Cabot A. 2012. Continuous production of Cu inf 2 inf ZnSnS inf 4 inf nanocrystals in a flow reactor. Journal of the American Chemical Society. 134(3), 1438–1441. mla: Shavel, Alexey, et al. “Continuous Production of Cu Inf 2 Inf ZnSnS Inf 4 Inf Nanocrystals in a Flow Reactor.” Journal of the American Chemical Society, vol. 134, no. 3, ACS, 2012, pp. 1438–41, doi:10.1021/ja209688a. short: A. Shavel, D. Cadavid, M. Ibáñez, A. Carrete, A. Cabot, Journal of the American Chemical Society 134 (2012) 1438–1441. date_created: 2018-12-11T11:45:54Z date_published: 2012-01-02T00:00:00Z date_updated: 2021-01-12T07:43:13Z day: '02' doi: 10.1021/ja209688a extern: '1' intvolume: ' 134' issue: '3' language: - iso: eng month: '01' oa_version: None page: 1438 - 1441 publication: Journal of the American Chemical Society publication_status: published publisher: ACS publist_id: '7490' quality_controlled: '1' status: public title: Continuous production of Cu inf 2 inf ZnSnS inf 4 inf nanocrystals in a flow reactor type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 134 year: '2012' ...