---
_id: '3317'
abstract:
- lang: eng
text: The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors
that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant
of the signalling properties of synapses in the nervous system. Recent functional
analysis indicates that in some fast central synapses, transmitter release is
triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors
at the nanometre scale. Molecular analysis suggests that this tight coupling is
generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors
and various other synaptic proteins. Nanodomain coupling has several functional
advantages, as it increases the efficacy, speed and energy efficiency of synaptic
transmission.
acknowledgement: "Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft
to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research
Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe
thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A.
Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial
support. We apologize that owing to space constraints, not all relevant papers could
be cited.\r\n"
author:
- first_name: Emmanuel
full_name: Eggermann, Emmanuel
id: 34DACA34-E9AE-11E9-849C-D35BD8ADC20C
last_name: Eggermann
- first_name: Iancu
full_name: Bucurenciu, Iancu
id: 4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A
last_name: Bucurenciu
- first_name: Sarit
full_name: Goswami, Sarit
id: 3A578F32-F248-11E8-B48F-1D18A9856A87
last_name: Goswami
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between
Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature
Reviews Neuroscience. 2012;13(1):7-21. doi:10.1038/nrn3125
apa: Eggermann, E., Bucurenciu, I., Goswami, S., & Jonas, P. M. (2012). Nanodomain
coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
Nature Reviews Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nrn3125
chicago: Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas.
“Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast
Mammalian Synapses.” Nature Reviews Neuroscience. Nature Publishing Group,
2012. https://doi.org/10.1038/nrn3125.
ieee: E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling
between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,”
Nature Reviews Neuroscience, vol. 13, no. 1. Nature Publishing Group, pp.
7–21, 2012.
ista: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling
between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
Nature Reviews Neuroscience. 13(1), 7–21.
mla: Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and
Sensors of Exocytosis at Fast Mammalian Synapses.” Nature Reviews Neuroscience,
vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:10.1038/nrn3125.
short: E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience
13 (2012) 7–21.
date_created: 2018-12-11T12:02:38Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:36Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/nrn3125
file:
- access_level: open_access
checksum: 4c1c86b2f6e4e1562f5bb800b457ea9f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:13Z
date_updated: 2020-07-14T12:46:07Z
file_id: '4931'
file_name: IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf
file_size: 314246
relation: main_file
- access_level: open_access
checksum: bceb2efdd49d115f4dde8486bc1be3f2
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:14Z
date_updated: 2020-07-14T12:46:07Z
file_id: '4932'
file_name: IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf
file_size: 1840216
relation: main_file
file_date_updated: 2020-07-14T12:46:07Z
has_accepted_license: '1'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 7 - 21
project:
- _id: 25BC64A8-B435-11E9-9278-68D0E5697425
grant_number: JO_780/A5
name: Synaptic Mechanisms of Neuronal Network Function
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
grant_number: SFB-TR3-TP10B
name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Nature Reviews Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3322'
pubrep_id: '820'
quality_controlled: '1'
scopus_import: 1
status: public
title: Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast
mammalian synapses
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2012'
...
---
_id: '3314'
abstract:
- lang: eng
text: We introduce two-level discounted and mean-payoff games played by two players
on a perfect-information stochastic game graph. The upper level game is a discounted
or mean-payoff game and the lower level game is a (undiscounted) reachability
game. Two-level games model hierarchical and sequential decision making under
uncertainty across different time scales. For both discounted and mean-payoff
two-level games, we show the existence of pure memoryless optimal strategies for
both players and an ordered field property. We show that if there is only one
player (Markov decision processes), then the values can be computed in polynomial
time. It follows that whether the value of a player is equal to a given rational
constant in two-level discounted or mean-payoff games can be decided in NP ∩ coNP.
We also give an alternate strategy improvement algorithm to compute the value.
© 2012 World Scientific Publishing Company.
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
citation:
ama: Chatterjee K, Majumdar R. Discounting and averaging in games across time scales.
International Journal of Foundations of Computer Science. 2012;23(3):609-625.
doi:10.1142/S0129054112400308
apa: Chatterjee, K., & Majumdar, R. (2012). Discounting and averaging in games
across time scales. International Journal of Foundations of Computer Science.
World Scientific Publishing. https://doi.org/10.1142/S0129054112400308
chicago: Chatterjee, Krishnendu, and Ritankar Majumdar. “Discounting and Averaging
in Games across Time Scales.” International Journal of Foundations of Computer
Science. World Scientific Publishing, 2012. https://doi.org/10.1142/S0129054112400308.
ieee: K. Chatterjee and R. Majumdar, “Discounting and averaging in games across
time scales,” International Journal of Foundations of Computer Science,
vol. 23, no. 3. World Scientific Publishing, pp. 609–625, 2012.
ista: Chatterjee K, Majumdar R. 2012. Discounting and averaging in games across
time scales. International Journal of Foundations of Computer Science. 23(3),
609–625.
mla: Chatterjee, Krishnendu, and Ritankar Majumdar. “Discounting and Averaging in
Games across Time Scales.” International Journal of Foundations of Computer
Science, vol. 23, no. 3, World Scientific Publishing, 2012, pp. 609–25, doi:10.1142/S0129054112400308.
short: K. Chatterjee, R. Majumdar, International Journal of Foundations of Computer
Science 23 (2012) 609–625.
date_created: 2018-12-11T12:02:37Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2021-01-12T07:42:35Z
day: '01'
department:
- _id: KrCh
doi: 10.1142/S0129054112400308
intvolume: ' 23'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 609 - 625
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2587B514-B435-11E9-9278-68D0E5697425
name: Microsoft Research Faculty Fellowship
publication: International Journal of Foundations of Computer Science
publication_status: published
publisher: World Scientific Publishing
publist_id: '3326'
quality_controlled: '1'
scopus_import: 1
status: public
title: Discounting and averaging in games across time scales
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2012'
...
---
_id: '3115'
abstract:
- lang: eng
text: 'We consider the offset-deconstruction problem: Given a polygonal shape Q
with n vertices, can it be expressed, up to a tolerance ε in Hausdorff distance,
as the Minkowski sum of another polygonal shape P with a disk of fixed radius?
If it does, we also seek a preferably simple-looking solution P; then, P''s offset
constitutes an accurate, vertex-reduced, and smoothened approximation of Q. We
give an O(nlogn)-time exact decision algorithm that handles any polygonal shape,
assuming the real-RAM model of computation. A variant of the algorithm, which
we have implemented using the cgal library, is based on rational arithmetic and
answers the same deconstruction problem up to an uncertainty parameter δ its running
time additionally depends on δ. If the input shape is found to be approximable,
this algorithm also computes an approximate solution for the problem. It also
allows us to solve parameter-optimization problems induced by the offset-deconstruction
problem. For convex shapes, the complexity of the exact decision algorithm drops
to O(n), which is also the time required to compute a solution P with at most
one more vertex than a vertex-minimal one.'
acknowledgement: "We thank Eyal Flato (Plataine Ltd.) for raising the offset-deconstruction
problem in connection with wood cutting. We also thank Tim Bretl (UIUC) for suggesting
the digital-pen offset-deconstruction problem. This work has been supported in part
by the Israel Science Foundation (grant no. 1102/11), by the German–Israeli Foundation
(grant no. 969/07), by the Hermann Minkowski–Minerva Center for Geometry at Tel
Aviv University, and by the EU Project under Contract No. 255827 (CGL—Computational
Geometry Learning).\r\n"
author:
- first_name: Eric
full_name: Berberich, Eric
last_name: Berberich
- first_name: Dan
full_name: Halperin, Dan
last_name: Halperin
- first_name: Michael
full_name: Kerber, Michael
id: 36E4574A-F248-11E8-B48F-1D18A9856A87
last_name: Kerber
orcid: 0000-0002-8030-9299
- first_name: Roza
full_name: Pogalnikova, Roza
last_name: Pogalnikova
citation:
ama: Berberich E, Halperin D, Kerber M, Pogalnikova R. Deconstructing approximate
offsets. Discrete & Computational Geometry. 2012;48(4):964-989. doi:10.1007/s00454-012-9441-5
apa: Berberich, E., Halperin, D., Kerber, M., & Pogalnikova, R. (2012). Deconstructing
approximate offsets. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-012-9441-5
chicago: Berberich, Eric, Dan Halperin, Michael Kerber, and Roza Pogalnikova. “Deconstructing
Approximate Offsets.” Discrete & Computational Geometry. Springer,
2012. https://doi.org/10.1007/s00454-012-9441-5.
ieee: E. Berberich, D. Halperin, M. Kerber, and R. Pogalnikova, “Deconstructing
approximate offsets,” Discrete & Computational Geometry, vol. 48, no.
4. Springer, pp. 964–989, 2012.
ista: Berberich E, Halperin D, Kerber M, Pogalnikova R. 2012. Deconstructing approximate
offsets. Discrete & Computational Geometry. 48(4), 964–989.
mla: Berberich, Eric, et al. “Deconstructing Approximate Offsets.” Discrete &
Computational Geometry, vol. 48, no. 4, Springer, 2012, pp. 964–89, doi:10.1007/s00454-012-9441-5.
short: E. Berberich, D. Halperin, M. Kerber, R. Pogalnikova, Discrete & Computational
Geometry 48 (2012) 964–989.
date_created: 2018-12-11T12:01:28Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2023-02-23T11:22:30Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/s00454-012-9441-5
external_id:
arxiv:
- '1109.2158'
intvolume: ' 48'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1109.2158
month: '12'
oa: 1
oa_version: Preprint
page: 964 - 989
publication: Discrete & Computational Geometry
publication_status: published
publisher: Springer
publist_id: '3584'
quality_controlled: '1'
related_material:
record:
- id: '3329'
relation: earlier_version
status: public
scopus_import: 1
status: public
title: Deconstructing approximate offsets
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2012'
...
---
_id: '3331'
abstract:
- lang: eng
text: Computing the topology of an algebraic plane curve C means computing a combinatorial
graph that is isotopic to C and thus represents its topology in R2. We prove that,
for a polynomial of degree n with integer coefficients bounded by 2ρ, the topology
of the induced curve can be computed with bit operations ( indicates that we
omit logarithmic factors). Our analysis improves the previous best known complexity
bounds by a factor of n2. The improvement is based on new techniques to compute
and refine isolating intervals for the real roots of polynomials, and on the consequent
amortized analysis of the critical fibers of the algebraic curve.
author:
- first_name: Michael
full_name: Kerber, Michael
id: 36E4574A-F248-11E8-B48F-1D18A9856A87
last_name: Kerber
orcid: 0000-0002-8030-9299
- first_name: Michael
full_name: Sagraloff, Michael
last_name: Sagraloff
citation:
ama: Kerber M, Sagraloff M. A worst case bound for topology computation of algebraic
curves. Journal of Symbolic Computation. 2012;47(3):239-258. doi:10.1016/j.jsc.2011.11.001
apa: Kerber, M., & Sagraloff, M. (2012). A worst case bound for topology computation
of algebraic curves. Journal of Symbolic Computation. Elsevier. https://doi.org/10.1016/j.jsc.2011.11.001
chicago: Kerber, Michael, and Michael Sagraloff. “A Worst Case Bound for Topology
Computation of Algebraic Curves.” Journal of Symbolic Computation. Elsevier,
2012. https://doi.org/10.1016/j.jsc.2011.11.001.
ieee: M. Kerber and M. Sagraloff, “A worst case bound for topology computation of
algebraic curves,” Journal of Symbolic Computation, vol. 47, no. 3. Elsevier,
pp. 239–258, 2012.
ista: Kerber M, Sagraloff M. 2012. A worst case bound for topology computation of
algebraic curves. Journal of Symbolic Computation. 47(3), 239–258.
mla: Kerber, Michael, and Michael Sagraloff. “A Worst Case Bound for Topology Computation
of Algebraic Curves.” Journal of Symbolic Computation, vol. 47, no. 3,
Elsevier, 2012, pp. 239–58, doi:10.1016/j.jsc.2011.11.001.
short: M. Kerber, M. Sagraloff, Journal of Symbolic Computation 47 (2012) 239–258.
date_created: 2018-12-11T12:02:43Z
date_published: 2012-03-01T00:00:00Z
date_updated: 2021-01-12T07:42:43Z
day: '01'
department:
- _id: HeEd
doi: 10.1016/j.jsc.2011.11.001
intvolume: ' 47'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1104.1510
month: '03'
oa: 1
oa_version: Preprint
page: 239 - 258
publication: ' Journal of Symbolic Computation'
publication_status: published
publisher: Elsevier
publist_id: '3303'
quality_controlled: '1'
scopus_import: 1
status: public
title: A worst case bound for topology computation of algebraic curves
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2012'
...
---
_id: '346'
abstract:
- lang: eng
text: Arrays of vertically aligned ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell
nanowires (NWs) were prepared by means of the combination of two solution-growth
processes. First, single-crystal ZnO NWs with controlled n-type doping were grown
on conducting substrates by a low-cost, high-yield and seed-free electrochemical
route. These NWs were covered by a titanium oxide shell of tunable thickness mediating
successive adsorption-hydrolysis-condensation steps. Using this atomic-layer growth
procedure, titania shells with controlled thickness and the anatase TiO2 phase
were obtained after sintering at 450 °C. Higher sintering temperatures resulted
in the formation of ZnO : Cl/ZnxTiOy/TiO2 core–shell NWs by the interdiffusion
of Zn and Ti ions at the ZnO–TiO2 interface. The performance of ZnO : Cl/TiO2
and ZnO : Cl/ZnxTiOy/TiO2 core–shell NWs towards photoelectrochemical (PEC) water
splitting was investigated as a function of the titania shell thickness. Furthermore,
the performance of such core–shell NWs as photoelectrodes in dye-sensitized solar
cells was also characterized. The TiO2 presence at the ZnO : Cl surface promoted
a two-fold increase on the produced photocurrent densities, probing their potential
for PEC and optoelectronic applications. Electrochemical impedance spectroscopy
was used to corroborate the lower resistance for charge transfer between the NWs
and the electrolyte in the presence of the TiO2 shell.
acknowledgement: The research was supported by the European Regional Development Funds
and the Spanish MICINN projects MAT2010-15138, MAT2010-21510 and CSD2009-00050.
JF and AS thank the FI-DGR and BP grants from the Agència de Gestió d'Ajuts Universitaris
i de Recerca (AGAUR) from the Catalan Government. MI and AC thank the Spanish MICINN
for the PhD grant and the financial support through the Ramóny Cajal program.
article_processing_charge: No
article_type: original
author:
- first_name: Jiandong
full_name: Fan, Jiandong
last_name: Fan
- first_name: Reza
full_name: Zamani, Reza
last_name: Zamani
- first_name: Cristina
full_name: Fábrega, Cristina
last_name: Fábrega
- first_name: Alexey
full_name: Shavel, Alexey
last_name: Shavel
- first_name: Cristina
full_name: Flox, Cristina
last_name: Flox
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Teresa
full_name: Andreu, Teresa
last_name: Andreu
- first_name: Amtonio
full_name: López, Amtonio
last_name: López
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Joan
full_name: Morante, Joan
last_name: Morante
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: 'Fan J, Zamani R, Fábrega C, et al. Solution-growth and optoelectronic performance
of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell
thickness. Journal of Physics D: Applied Physics. 2012;45(41). doi:10.1088/0022-3727/45/41/415301'
apa: 'Fan, J., Zamani, R., Fábrega, C., Shavel, A., Flox, C., Ibáñez, M., … Cabot,
A. (2012). Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and
ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness. Journal
of Physics D: Applied Physics. IOP Publishing Ltd. https://doi.org/10.1088/0022-3727/45/41/415301'
chicago: 'Fan, Jiandong, Reza Zamani, Cristina Fábrega, Alexey Shavel, Cristina
Flox, Maria Ibáñez, Teresa Andreu, et al. “Solution-Growth and Optoelectronic
Performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 Core–Shell Nanowires with
Tunable Shell Thickness.” Journal of Physics D: Applied Physics. IOP Publishing
Ltd., 2012. https://doi.org/10.1088/0022-3727/45/41/415301.'
ieee: 'J. Fan et al., “Solution-growth and optoelectronic performance of
ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell
thickness,” Journal of Physics D: Applied Physics, vol. 45, no. 41. IOP
Publishing Ltd., 2012.'
ista: 'Fan J, Zamani R, Fábrega C, Shavel A, Flox C, Ibáñez M, Andreu T, López A,
Arbiol J, Morante J, Cabot A. 2012. Solution-growth and optoelectronic performance
of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell
thickness. Journal of Physics D: Applied Physics. 45(41).'
mla: 'Fan, Jiandong, et al. “Solution-Growth and Optoelectronic Performance of ZnO : Cl/TiO2
and ZnO : Cl/ZnxTiOy/TiO2 Core–Shell Nanowires with Tunable Shell Thickness.”
Journal of Physics D: Applied Physics, vol. 45, no. 41, IOP Publishing
Ltd., 2012, doi:10.1088/0022-3727/45/41/415301.'
short: 'J. Fan, R. Zamani, C. Fábrega, A. Shavel, C. Flox, M. Ibáñez, T. Andreu,
A. López, J. Arbiol, J. Morante, A. Cabot, Journal of Physics D: Applied Physics
45 (2012).'
date_created: 2018-12-11T11:45:56Z
date_published: 2012-10-17T00:00:00Z
date_updated: 2021-01-12T07:43:36Z
day: '17'
doi: 10.1088/0022-3727/45/41/415301
extern: '1'
intvolume: ' 45'
issue: '41'
language:
- iso: eng
month: '10'
oa_version: None
publication: 'Journal of Physics D: Applied Physics'
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '7486'
quality_controlled: '1'
status: public
title: Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2
core–shell nanowires with tunable shell thickness
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2012'
...