--- _id: '3317' abstract: - lang: eng text: The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission. acknowledgement: "Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A. Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial support. We apologize that owing to space constraints, not all relevant papers could be cited.\r\n" author: - first_name: Emmanuel full_name: Eggermann, Emmanuel id: 34DACA34-E9AE-11E9-849C-D35BD8ADC20C last_name: Eggermann - first_name: Iancu full_name: Bucurenciu, Iancu id: 4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A last_name: Bucurenciu - first_name: Sarit full_name: Goswami, Sarit id: 3A578F32-F248-11E8-B48F-1D18A9856A87 last_name: Goswami - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. 2012;13(1):7-21. doi:10.1038/nrn3125 apa: Eggermann, E., Bucurenciu, I., Goswami, S., & Jonas, P. M. (2012). Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nrn3125 chicago: Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” Nature Reviews Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nrn3125. ieee: E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,” Nature Reviews Neuroscience, vol. 13, no. 1. Nature Publishing Group, pp. 7–21, 2012. ista: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. 13(1), 7–21. mla: Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” Nature Reviews Neuroscience, vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:10.1038/nrn3125. short: E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience 13 (2012) 7–21. date_created: 2018-12-11T12:02:38Z date_published: 2012-01-01T00:00:00Z date_updated: 2021-01-12T07:42:36Z day: '01' ddc: - '570' department: - _id: PeJo doi: 10.1038/nrn3125 file: - access_level: open_access checksum: 4c1c86b2f6e4e1562f5bb800b457ea9f content_type: application/pdf creator: system date_created: 2018-12-12T10:12:13Z date_updated: 2020-07-14T12:46:07Z file_id: '4931' file_name: IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf file_size: 314246 relation: main_file - access_level: open_access checksum: bceb2efdd49d115f4dde8486bc1be3f2 content_type: application/pdf creator: system date_created: 2018-12-12T10:12:14Z date_updated: 2020-07-14T12:46:07Z file_id: '4932' file_name: IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf file_size: 1840216 relation: main_file file_date_updated: 2020-07-14T12:46:07Z has_accepted_license: '1' intvolume: ' 13' issue: '1' language: - iso: eng month: '01' oa: 1 oa_version: Submitted Version page: 7 - 21 project: - _id: 25BC64A8-B435-11E9-9278-68D0E5697425 grant_number: JO_780/A5 name: Synaptic Mechanisms of Neuronal Network Function - _id: 25BDE9A4-B435-11E9-9278-68D0E5697425 grant_number: SFB-TR3-TP10B name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen publication: Nature Reviews Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '3322' pubrep_id: '820' quality_controlled: '1' scopus_import: 1 status: public title: Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 13 year: '2012' ... --- _id: '3314' abstract: - lang: eng text: We introduce two-level discounted and mean-payoff games played by two players on a perfect-information stochastic game graph. The upper level game is a discounted or mean-payoff game and the lower level game is a (undiscounted) reachability game. Two-level games model hierarchical and sequential decision making under uncertainty across different time scales. For both discounted and mean-payoff two-level games, we show the existence of pure memoryless optimal strategies for both players and an ordered field property. We show that if there is only one player (Markov decision processes), then the values can be computed in polynomial time. It follows that whether the value of a player is equal to a given rational constant in two-level discounted or mean-payoff games can be decided in NP ∩ coNP. We also give an alternate strategy improvement algorithm to compute the value. © 2012 World Scientific Publishing Company. author: - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar citation: ama: Chatterjee K, Majumdar R. Discounting and averaging in games across time scales. International Journal of Foundations of Computer Science. 2012;23(3):609-625. doi:10.1142/S0129054112400308 apa: Chatterjee, K., & Majumdar, R. (2012). Discounting and averaging in games across time scales. International Journal of Foundations of Computer Science. World Scientific Publishing. https://doi.org/10.1142/S0129054112400308 chicago: Chatterjee, Krishnendu, and Ritankar Majumdar. “Discounting and Averaging in Games across Time Scales.” International Journal of Foundations of Computer Science. World Scientific Publishing, 2012. https://doi.org/10.1142/S0129054112400308. ieee: K. Chatterjee and R. Majumdar, “Discounting and averaging in games across time scales,” International Journal of Foundations of Computer Science, vol. 23, no. 3. World Scientific Publishing, pp. 609–625, 2012. ista: Chatterjee K, Majumdar R. 2012. Discounting and averaging in games across time scales. International Journal of Foundations of Computer Science. 23(3), 609–625. mla: Chatterjee, Krishnendu, and Ritankar Majumdar. “Discounting and Averaging in Games across Time Scales.” International Journal of Foundations of Computer Science, vol. 23, no. 3, World Scientific Publishing, 2012, pp. 609–25, doi:10.1142/S0129054112400308. short: K. Chatterjee, R. Majumdar, International Journal of Foundations of Computer Science 23 (2012) 609–625. date_created: 2018-12-11T12:02:37Z date_published: 2012-04-01T00:00:00Z date_updated: 2021-01-12T07:42:35Z day: '01' department: - _id: KrCh doi: 10.1142/S0129054112400308 intvolume: ' 23' issue: '3' language: - iso: eng month: '04' oa_version: None page: 609 - 625 project: - _id: 25832EC2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: S 11407_N23 name: Rigorous Systems Engineering - _id: 2587B514-B435-11E9-9278-68D0E5697425 name: Microsoft Research Faculty Fellowship publication: International Journal of Foundations of Computer Science publication_status: published publisher: World Scientific Publishing publist_id: '3326' quality_controlled: '1' scopus_import: 1 status: public title: Discounting and averaging in games across time scales type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 23 year: '2012' ... --- _id: '3115' abstract: - lang: eng text: 'We consider the offset-deconstruction problem: Given a polygonal shape Q with n vertices, can it be expressed, up to a tolerance ε in Hausdorff distance, as the Minkowski sum of another polygonal shape P with a disk of fixed radius? If it does, we also seek a preferably simple-looking solution P; then, P''s offset constitutes an accurate, vertex-reduced, and smoothened approximation of Q. We give an O(nlogn)-time exact decision algorithm that handles any polygonal shape, assuming the real-RAM model of computation. A variant of the algorithm, which we have implemented using the cgal library, is based on rational arithmetic and answers the same deconstruction problem up to an uncertainty parameter δ its running time additionally depends on δ. If the input shape is found to be approximable, this algorithm also computes an approximate solution for the problem. It also allows us to solve parameter-optimization problems induced by the offset-deconstruction problem. For convex shapes, the complexity of the exact decision algorithm drops to O(n), which is also the time required to compute a solution P with at most one more vertex than a vertex-minimal one.' acknowledgement: "We thank Eyal Flato (Plataine Ltd.) for raising the offset-deconstruction problem in connection with wood cutting. We also thank Tim Bretl (UIUC) for suggesting the digital-pen offset-deconstruction problem. This work has been supported in part by the Israel Science Foundation (grant no. 1102/11), by the German–Israeli Foundation (grant no. 969/07), by the Hermann Minkowski–Minerva Center for Geometry at Tel Aviv University, and by the EU Project under Contract No. 255827 (CGL—Computational Geometry Learning).\r\n" author: - first_name: Eric full_name: Berberich, Eric last_name: Berberich - first_name: Dan full_name: Halperin, Dan last_name: Halperin - first_name: Michael full_name: Kerber, Michael id: 36E4574A-F248-11E8-B48F-1D18A9856A87 last_name: Kerber orcid: 0000-0002-8030-9299 - first_name: Roza full_name: Pogalnikova, Roza last_name: Pogalnikova citation: ama: Berberich E, Halperin D, Kerber M, Pogalnikova R. Deconstructing approximate offsets. Discrete & Computational Geometry. 2012;48(4):964-989. doi:10.1007/s00454-012-9441-5 apa: Berberich, E., Halperin, D., Kerber, M., & Pogalnikova, R. (2012). Deconstructing approximate offsets. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-012-9441-5 chicago: Berberich, Eric, Dan Halperin, Michael Kerber, and Roza Pogalnikova. “Deconstructing Approximate Offsets.” Discrete & Computational Geometry. Springer, 2012. https://doi.org/10.1007/s00454-012-9441-5. ieee: E. Berberich, D. Halperin, M. Kerber, and R. Pogalnikova, “Deconstructing approximate offsets,” Discrete & Computational Geometry, vol. 48, no. 4. Springer, pp. 964–989, 2012. ista: Berberich E, Halperin D, Kerber M, Pogalnikova R. 2012. Deconstructing approximate offsets. Discrete & Computational Geometry. 48(4), 964–989. mla: Berberich, Eric, et al. “Deconstructing Approximate Offsets.” Discrete & Computational Geometry, vol. 48, no. 4, Springer, 2012, pp. 964–89, doi:10.1007/s00454-012-9441-5. short: E. Berberich, D. Halperin, M. Kerber, R. Pogalnikova, Discrete & Computational Geometry 48 (2012) 964–989. date_created: 2018-12-11T12:01:28Z date_published: 2012-12-01T00:00:00Z date_updated: 2023-02-23T11:22:30Z day: '01' department: - _id: HeEd doi: 10.1007/s00454-012-9441-5 external_id: arxiv: - '1109.2158' intvolume: ' 48' issue: '4' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1109.2158 month: '12' oa: 1 oa_version: Preprint page: 964 - 989 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '3584' quality_controlled: '1' related_material: record: - id: '3329' relation: earlier_version status: public scopus_import: 1 status: public title: Deconstructing approximate offsets type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 48 year: '2012' ... --- _id: '3331' abstract: - lang: eng text: Computing the topology of an algebraic plane curve C means computing a combinatorial graph that is isotopic to C and thus represents its topology in R2. We prove that, for a polynomial of degree n with integer coefficients bounded by 2ρ, the topology of the induced curve can be computed with bit operations ( indicates that we omit logarithmic factors). Our analysis improves the previous best known complexity bounds by a factor of n2. The improvement is based on new techniques to compute and refine isolating intervals for the real roots of polynomials, and on the consequent amortized analysis of the critical fibers of the algebraic curve. author: - first_name: Michael full_name: Kerber, Michael id: 36E4574A-F248-11E8-B48F-1D18A9856A87 last_name: Kerber orcid: 0000-0002-8030-9299 - first_name: Michael full_name: Sagraloff, Michael last_name: Sagraloff citation: ama: Kerber M, Sagraloff M. A worst case bound for topology computation of algebraic curves. Journal of Symbolic Computation. 2012;47(3):239-258. doi:10.1016/j.jsc.2011.11.001 apa: Kerber, M., & Sagraloff, M. (2012). A worst case bound for topology computation of algebraic curves. Journal of Symbolic Computation. Elsevier. https://doi.org/10.1016/j.jsc.2011.11.001 chicago: Kerber, Michael, and Michael Sagraloff. “A Worst Case Bound for Topology Computation of Algebraic Curves.” Journal of Symbolic Computation. Elsevier, 2012. https://doi.org/10.1016/j.jsc.2011.11.001. ieee: M. Kerber and M. Sagraloff, “A worst case bound for topology computation of algebraic curves,” Journal of Symbolic Computation, vol. 47, no. 3. Elsevier, pp. 239–258, 2012. ista: Kerber M, Sagraloff M. 2012. A worst case bound for topology computation of algebraic curves. Journal of Symbolic Computation. 47(3), 239–258. mla: Kerber, Michael, and Michael Sagraloff. “A Worst Case Bound for Topology Computation of Algebraic Curves.” Journal of Symbolic Computation, vol. 47, no. 3, Elsevier, 2012, pp. 239–58, doi:10.1016/j.jsc.2011.11.001. short: M. Kerber, M. Sagraloff, Journal of Symbolic Computation 47 (2012) 239–258. date_created: 2018-12-11T12:02:43Z date_published: 2012-03-01T00:00:00Z date_updated: 2021-01-12T07:42:43Z day: '01' department: - _id: HeEd doi: 10.1016/j.jsc.2011.11.001 intvolume: ' 47' issue: '3' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1104.1510 month: '03' oa: 1 oa_version: Preprint page: 239 - 258 publication: ' Journal of Symbolic Computation' publication_status: published publisher: Elsevier publist_id: '3303' quality_controlled: '1' scopus_import: 1 status: public title: A worst case bound for topology computation of algebraic curves type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 47 year: '2012' ... --- _id: '346' abstract: - lang: eng text: Arrays of vertically aligned ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires (NWs) were prepared by means of the combination of two solution-growth processes. First, single-crystal ZnO NWs with controlled n-type doping were grown on conducting substrates by a low-cost, high-yield and seed-free electrochemical route. These NWs were covered by a titanium oxide shell of tunable thickness mediating successive adsorption-hydrolysis-condensation steps. Using this atomic-layer growth procedure, titania shells with controlled thickness and the anatase TiO2 phase were obtained after sintering at 450 °C. Higher sintering temperatures resulted in the formation of ZnO : Cl/ZnxTiOy/TiO2 core–shell NWs by the interdiffusion of Zn and Ti ions at the ZnO–TiO2 interface. The performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell NWs towards photoelectrochemical (PEC) water splitting was investigated as a function of the titania shell thickness. Furthermore, the performance of such core–shell NWs as photoelectrodes in dye-sensitized solar cells was also characterized. The TiO2 presence at the ZnO : Cl surface promoted a two-fold increase on the produced photocurrent densities, probing their potential for PEC and optoelectronic applications. Electrochemical impedance spectroscopy was used to corroborate the lower resistance for charge transfer between the NWs and the electrolyte in the presence of the TiO2 shell. acknowledgement: The research was supported by the European Regional Development Funds and the Spanish MICINN projects MAT2010-15138, MAT2010-21510 and CSD2009-00050. JF and AS thank the FI-DGR and BP grants from the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) from the Catalan Government. MI and AC thank the Spanish MICINN for the PhD grant and the financial support through the Ramóny Cajal program. article_processing_charge: No article_type: original author: - first_name: Jiandong full_name: Fan, Jiandong last_name: Fan - first_name: Reza full_name: Zamani, Reza last_name: Zamani - first_name: Cristina full_name: Fábrega, Cristina last_name: Fábrega - first_name: Alexey full_name: Shavel, Alexey last_name: Shavel - first_name: Cristina full_name: Flox, Cristina last_name: Flox - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Teresa full_name: Andreu, Teresa last_name: Andreu - first_name: Amtonio full_name: López, Amtonio last_name: López - first_name: Jordi full_name: Arbiol, Jordi last_name: Arbiol - first_name: Joan full_name: Morante, Joan last_name: Morante - first_name: Andreu full_name: Cabot, Andreu last_name: Cabot citation: ama: 'Fan J, Zamani R, Fábrega C, et al. Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness. Journal of Physics D: Applied Physics. 2012;45(41). doi:10.1088/0022-3727/45/41/415301' apa: 'Fan, J., Zamani, R., Fábrega, C., Shavel, A., Flox, C., Ibáñez, M., … Cabot, A. (2012). Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness. Journal of Physics D: Applied Physics. IOP Publishing Ltd. https://doi.org/10.1088/0022-3727/45/41/415301' chicago: 'Fan, Jiandong, Reza Zamani, Cristina Fábrega, Alexey Shavel, Cristina Flox, Maria Ibáñez, Teresa Andreu, et al. “Solution-Growth and Optoelectronic Performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 Core–Shell Nanowires with Tunable Shell Thickness.” Journal of Physics D: Applied Physics. IOP Publishing Ltd., 2012. https://doi.org/10.1088/0022-3727/45/41/415301.' ieee: 'J. Fan et al., “Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness,” Journal of Physics D: Applied Physics, vol. 45, no. 41. IOP Publishing Ltd., 2012.' ista: 'Fan J, Zamani R, Fábrega C, Shavel A, Flox C, Ibáñez M, Andreu T, López A, Arbiol J, Morante J, Cabot A. 2012. Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness. Journal of Physics D: Applied Physics. 45(41).' mla: 'Fan, Jiandong, et al. “Solution-Growth and Optoelectronic Performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 Core–Shell Nanowires with Tunable Shell Thickness.” Journal of Physics D: Applied Physics, vol. 45, no. 41, IOP Publishing Ltd., 2012, doi:10.1088/0022-3727/45/41/415301.' short: 'J. Fan, R. Zamani, C. Fábrega, A. Shavel, C. Flox, M. Ibáñez, T. Andreu, A. López, J. Arbiol, J. Morante, A. Cabot, Journal of Physics D: Applied Physics 45 (2012).' date_created: 2018-12-11T11:45:56Z date_published: 2012-10-17T00:00:00Z date_updated: 2021-01-12T07:43:36Z day: '17' doi: 10.1088/0022-3727/45/41/415301 extern: '1' intvolume: ' 45' issue: '41' language: - iso: eng month: '10' oa_version: None publication: 'Journal of Physics D: Applied Physics' publication_status: published publisher: IOP Publishing Ltd. publist_id: '7486' quality_controlled: '1' status: public title: Solution-growth and optoelectronic performance of ZnO : Cl/TiO2 and ZnO : Cl/ZnxTiOy/TiO2 core–shell nanowires with tunable shell thickness type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 45 year: '2012' ...