---
_id: '2970'
abstract:
- lang: eng
text: Morphogen gradients regulate the patterning and growth of many tissues, hence
a key question is how they are established and maintained during development.
Theoretical descriptions have helped to explain how gradient shape is controlled
by the rates of morphogen production, spreading and degradation. These effective
rates have been measured using fluorescence recovery after photobleaching (FRAP)
and photoactivation. To unravel which molecular events determine the effective
rates, such tissue-level assays have been combined with genetic analysis, high-resolution
assays, and models that take into account interactions with receptors, extracellular
components and trafficking. Nevertheless, because of the natural and experimental
data variability, and the underlying assumptions of transport models, it remains
challenging to conclusively distinguish between cellular mechanisms.
acknowledgement: AK is currently supported by an MRC CDF. MGG and OW were supported
by the Swiss National Science Foundation, grants from the Swiss SystemsX.ch initiative,
LipidX-2008/011, an ERC advanced investigator grant and the Polish-Swiss research
program.
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Ortrud
full_name: Wartlick, Ortrud
last_name: Wartlick
- first_name: Frank
full_name: Julicher, Frank
last_name: Julicher
- first_name: Marcos
full_name: Gonzalez Gaitan, Marcos
last_name: Gonzalez Gaitan
citation:
ama: 'Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. Investigating
the principles of morphogen gradient formation: from tissues to cells. Current
Opinion in Genetics & Development. 2012;22(6):527-532. doi:10.1016/j.gde.2012.08.004'
apa: 'Kicheva, A., Bollenbach, M. T., Wartlick, O., Julicher, F., & Gonzalez
Gaitan, M. (2012). Investigating the principles of morphogen gradient formation:
from tissues to cells. Current Opinion in Genetics & Development. Elsevier.
https://doi.org/10.1016/j.gde.2012.08.004'
chicago: 'Kicheva, Anna, Mark Tobias Bollenbach, Ortrud Wartlick, Frank Julicher,
and Marcos Gonzalez Gaitan. “Investigating the Principles of Morphogen Gradient
Formation: From Tissues to Cells.” Current Opinion in Genetics & Development.
Elsevier, 2012. https://doi.org/10.1016/j.gde.2012.08.004.'
ieee: 'A. Kicheva, M. T. Bollenbach, O. Wartlick, F. Julicher, and M. Gonzalez Gaitan,
“Investigating the principles of morphogen gradient formation: from tissues to
cells,” Current Opinion in Genetics & Development, vol. 22, no. 6.
Elsevier, pp. 527–532, 2012.'
ista: 'Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. 2012.
Investigating the principles of morphogen gradient formation: from tissues to
cells. Current Opinion in Genetics & Development. 22(6), 527–532.'
mla: 'Kicheva, Anna, et al. “Investigating the Principles of Morphogen Gradient
Formation: From Tissues to Cells.” Current Opinion in Genetics & Development,
vol. 22, no. 6, Elsevier, 2012, pp. 527–32, doi:10.1016/j.gde.2012.08.004.'
short: A. Kicheva, M.T. Bollenbach, O. Wartlick, F. Julicher, M. Gonzalez Gaitan,
Current Opinion in Genetics & Development 22 (2012) 527–532.
date_created: 2018-12-11T12:00:37Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2021-01-12T07:40:09Z
day: '01'
department:
- _id: ToBo
doi: 10.1016/j.gde.2012.08.004
intvolume: ' 22'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 527 - 532
publication: Current Opinion in Genetics & Development
publication_status: published
publisher: Elsevier
publist_id: '3739'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Investigating the principles of morphogen gradient formation: from tissues
to cells'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '2971'
abstract:
- lang: eng
text: 'We study the task of interactive semantic labeling of a segmentation hierarchy.
To this end we propose a framework interleaving two components: an automatic labeling
step, based on a Conditional Random Field whose dependencies are defined by the
inclusion tree of the segmentation hierarchy, and an interaction step that integrates
incremental input from a human user. Evaluated on two distinct datasets, the proposed
interactive approach efficiently integrates human interventions and illustrates
the advantages of structured prediction in an interactive framework. '
author:
- first_name: Georg
full_name: Zankl, Georg
last_name: Zankl
- first_name: Yll
full_name: Haxhimusa, Yll
last_name: Haxhimusa
- first_name: Adrian
full_name: Ion, Adrian
id: 29F89302-F248-11E8-B48F-1D18A9856A87
last_name: Ion
citation:
ama: 'Zankl G, Haxhimusa Y, Ion A. Interactive labeling of image segmentation hierarchies.
In: Vol 7476. Springer; 2012:11-20. doi:10.1007/978-3-642-32717-9_2'
apa: 'Zankl, G., Haxhimusa, Y., & Ion, A. (2012). Interactive labeling of image
segmentation hierarchies (Vol. 7476, pp. 11–20). Presented at the Pattern Recognition,
Graz, Austria: Springer. https://doi.org/10.1007/978-3-642-32717-9_2'
chicago: Zankl, Georg, Yll Haxhimusa, and Adrian Ion. “Interactive Labeling of Image
Segmentation Hierarchies,” 7476:11–20. Springer, 2012. https://doi.org/10.1007/978-3-642-32717-9_2.
ieee: G. Zankl, Y. Haxhimusa, and A. Ion, “Interactive labeling of image segmentation
hierarchies,” presented at the Pattern Recognition, Graz, Austria, 2012, vol.
7476, pp. 11–20.
ista: Zankl G, Haxhimusa Y, Ion A. 2012. Interactive labeling of image segmentation
hierarchies. Pattern Recognition vol. 7476, 11–20.
mla: Zankl, Georg, et al. Interactive Labeling of Image Segmentation Hierarchies.
Vol. 7476, Springer, 2012, pp. 11–20, doi:10.1007/978-3-642-32717-9_2.
short: G. Zankl, Y. Haxhimusa, A. Ion, in:, Springer, 2012, pp. 11–20.
conference:
end_date: 2012-08-31
location: Graz, Austria
name: Pattern Recognition
start_date: 2012-08-28
date_created: 2018-12-11T12:00:37Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T07:40:10Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/978-3-642-32717-9_2
intvolume: ' 7476'
language:
- iso: eng
month: '01'
oa_version: None
page: 11 - 20
publication_status: published
publisher: Springer
publist_id: '3737'
quality_controlled: '1'
scopus_import: 1
status: public
title: Interactive labeling of image segmentation hierarchies
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7476
year: '2012'
...
---
_id: '3105'
abstract:
- lang: eng
text: Growth and development are coordinated by an array of intercellular communications.
Known plant signaling molecules include phytohormones and hormone peptides. Although
both classes can be implicated in the same developmental processes, little is
known about the interplay between phytohormone action and peptide signaling within
the cellular microenvironment. We show that genes coding for small secretory peptides,
designated GOLVEN (GLV), modulate the distribution of the phytohormone auxin.
The deregulation of the GLV function impairs the formation of auxin gradients
and alters the reorientation of shoots and roots after a gravity stimulus. Specifically,
the GLV signal modulates the trafficking dynamics of the auxin efflux carrier
PIN-FORMED2 involved in root tropic responses and meristem organization. Our work
links the local action of secretory peptides with phytohormone transport. Root
growth factor (RGF) or GOLVEN (GLV) secreted peptides have previously been implicated
in meristem regulation. Whitford et al. now show that RGF/GLV peptides induce
rapid relocalization of the auxin efflux regulator PIN2, regulate auxin gradients,
and modulate auxin-dependent root responses to specific stimuli.
author:
- first_name: Ryan
full_name: Whitford, Ryan
last_name: Whitford
- first_name: Ana
full_name: Fernandez, Ana
last_name: Fernandez
- first_name: Ricardo
full_name: Tejos, Ricardo
last_name: Tejos
- first_name: Amparo
full_name: Pérez, Amparo Cuéllar
last_name: Pérez
- first_name: Jürgen
full_name: Kleine-Vehn, Jürgen
last_name: Kleine Vehn
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Andrzej
full_name: Drozdzecki, Andrzej
last_name: Drozdzecki
- first_name: Johannes
full_name: Leitner, Johannes
last_name: Leitner
- first_name: Lindy
full_name: Abas, Lindy
last_name: Abas
- first_name: Maarten
full_name: Aerts, Maarten
last_name: Aerts
- first_name: Kurt
full_name: Hoogewijs, Kurt
last_name: Hoogewijs
- first_name: Pawel
full_name: Pawel Baster
id: 3028BD74-F248-11E8-B48F-1D18A9856A87
last_name: Baster
- first_name: Ruth
full_name: De Groodt, Ruth
last_name: De Groodt
- first_name: Yao
full_name: Lin, Yao-Cheng
last_name: Lin
- first_name: Véronique
full_name: Storme, Véronique
last_name: Storme
- first_name: Yves
full_name: Van de Peer, Yves
last_name: Van De Peer
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Annemieke
full_name: Madder, Annemieke
last_name: Madder
- first_name: Bart
full_name: Devreese, Bart
last_name: Devreese
- first_name: Christian
full_name: Luschnig, Christian
last_name: Luschnig
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Pierre
full_name: Hilson, Pierre
last_name: Hilson
citation:
ama: Whitford R, Fernandez A, Tejos R, et al. GOLVEN secretory peptides regulate
auxin carrier turnover during plant gravitropic responses. Developmental Cell.
2012;22(3):678-685. doi:10.1016/j.devcel.2012.02.002
apa: Whitford, R., Fernandez, A., Tejos, R., Pérez, A., Kleine Vehn, J., Vanneste,
S., … Hilson, P. (2012). GOLVEN secretory peptides regulate auxin carrier turnover
during plant gravitropic responses. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2012.02.002
chicago: Whitford, Ryan, Ana Fernandez, Ricardo Tejos, Amparo Pérez, Jürgen Kleine
Vehn, Steffen Vanneste, Andrzej Drozdzecki, et al. “GOLVEN Secretory Peptides
Regulate Auxin Carrier Turnover during Plant Gravitropic Responses.” Developmental
Cell. Cell Press, 2012. https://doi.org/10.1016/j.devcel.2012.02.002.
ieee: R. Whitford et al., “GOLVEN secretory peptides regulate auxin carrier
turnover during plant gravitropic responses,” Developmental Cell, vol.
22, no. 3. Cell Press, pp. 678–685, 2012.
ista: Whitford R, Fernandez A, Tejos R, Pérez A, Kleine Vehn J, Vanneste S, Drozdzecki
A, Leitner J, Abas L, Aerts M, Hoogewijs K, Baster P, De Groodt R, Lin Y, Storme
V, Van De Peer Y, Beeckman T, Madder A, Devreese B, Luschnig C, Friml J, Hilson
P. 2012. GOLVEN secretory peptides regulate auxin carrier turnover during plant
gravitropic responses. Developmental Cell. 22(3), 678–685.
mla: Whitford, Ryan, et al. “GOLVEN Secretory Peptides Regulate Auxin Carrier Turnover
during Plant Gravitropic Responses.” Developmental Cell, vol. 22, no. 3,
Cell Press, 2012, pp. 678–85, doi:10.1016/j.devcel.2012.02.002.
short: R. Whitford, A. Fernandez, R. Tejos, A. Pérez, J. Kleine Vehn, S. Vanneste,
A. Drozdzecki, J. Leitner, L. Abas, M. Aerts, K. Hoogewijs, P. Baster, R. De Groodt,
Y. Lin, V. Storme, Y. Van De Peer, T. Beeckman, A. Madder, B. Devreese, C. Luschnig,
J. Friml, P. Hilson, Developmental Cell 22 (2012) 678–685.
date_created: 2018-12-11T12:01:25Z
date_published: 2012-03-13T00:00:00Z
date_updated: 2021-01-12T07:41:06Z
day: '13'
doi: 10.1016/j.devcel.2012.02.002
extern: 1
intvolume: ' 22'
issue: '3'
month: '03'
page: 678 - 685
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3594'
quality_controlled: 0
status: public
title: GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic
responses
type: journal_article
volume: 22
year: '2012'
...
---
_id: '3109'
abstract:
- lang: eng
text: Receptor-mediated endocytosis is an integral part of signal transduction as
it mediates signal attenuation and provides spatial and temporal dimensions to
signaling events. One of the best-studied leucine-rich repeat receptor-like kinases
in plants, BRASSINOSTEROID INSENSITIVE 1 (BRI1), perceives its ligand, the brassinosteroid
(BR) hormone, at the cell surface and is constitutively endocytosed. However,
the importance of endocytosis for BR signaling remains unclear. Here we developed
a bioactive, fluorescent BR analog, Alexa Fluor 647-castasterone (AFCS), and visualized
the endocytosis of BRI1-AFCS complexes in living Arabidopsis thaliana cells. Impairment
of endocytosis dependent on clathrin and the guanine nucleotide exchange factor
for ARF GTPases (ARF-GEF) GNOM enhanced BR signaling by retaining active BRI1-ligand
complexes at the plasma membrane. Increasing the trans-Golgi network/early endosome
pool of BRI1-BR complexes did not affect BR signaling. Our findings provide what
is to our knowledge the first visualization of receptor-ligand complexes in plants
and reveal clathrin-and ARF-GEF-dependent endocytic regulation of BR signaling
from the plasma membrane.
author:
- first_name: Niloufer
full_name: Irani, Niloufer G
last_name: Irani
- first_name: Simone
full_name: Di Rubbo, Simone
last_name: Di Rubbo
- first_name: Evelien
full_name: Mylle, Evelien
last_name: Mylle
- first_name: Jos
full_name: Van Den Begin, Jos
last_name: Van Den Begin
- first_name: Joanna
full_name: Schneider-Pizoń, Joanna
last_name: Schneider Pizoń
- first_name: Jaroslava
full_name: Hniliková, Jaroslava
last_name: Hniliková
- first_name: Miroslav
full_name: Šíša, Miroslav
last_name: Šíša
- first_name: Dieter
full_name: Buyst, Dieter
last_name: Buyst
- first_name: Josep
full_name: Vilarrasa-Blasi, Josep
last_name: Vilarrasa Blasi
- first_name: Anna
full_name: Szatmári, Anna-Maria
last_name: Szatmári
- first_name: Daniël
full_name: Van Damme, Daniël
last_name: Van Damme
- first_name: Kiril
full_name: Mishev, Kiril
last_name: Mishev
- first_name: Mirela
full_name: Codreanu, Mirela-Corina
last_name: Codreanu
- first_name: Ladislav
full_name: Kohout, Ladislav
last_name: Kohout
- first_name: Miroslav
full_name: Strnad, Miroslav
last_name: Strnad
- first_name: Ana
full_name: Caño-Delgado, Ana I
last_name: Caño Delgado
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Annemieke
full_name: Madder, Annemieke
last_name: Madder
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
citation:
ama: Irani N, Di Rubbo S, Mylle E, et al. Fluorescent castasterone reveals BRI1
signaling from the plasma membrane. Nature Chemical Biology. 2012;8(6):583-589.
doi:10.1038/nchembio.958
apa: Irani, N., Di Rubbo, S., Mylle, E., Van Den Begin, J., Schneider Pizoń, J.,
Hniliková, J., … Russinova, E. (2012). Fluorescent castasterone reveals BRI1 signaling
from the plasma membrane. Nature Chemical Biology. Nature Publishing Group.
https://doi.org/10.1038/nchembio.958
chicago: Irani, Niloufer, Simone Di Rubbo, Evelien Mylle, Jos Van Den Begin, Joanna
Schneider Pizoń, Jaroslava Hniliková, Miroslav Šíša, et al. “Fluorescent Castasterone
Reveals BRI1 Signaling from the Plasma Membrane.” Nature Chemical Biology.
Nature Publishing Group, 2012. https://doi.org/10.1038/nchembio.958.
ieee: N. Irani et al., “Fluorescent castasterone reveals BRI1 signaling from
the plasma membrane,” Nature Chemical Biology, vol. 8, no. 6. Nature Publishing
Group, pp. 583–589, 2012.
ista: Irani N, Di Rubbo S, Mylle E, Van Den Begin J, Schneider Pizoń J, Hniliková
J, Šíša M, Buyst D, Vilarrasa Blasi J, Szatmári A, Van Damme D, Mishev K, Codreanu
M, Kohout L, Strnad M, Caño Delgado A, Friml J, Madder A, Russinova E. 2012. Fluorescent
castasterone reveals BRI1 signaling from the plasma membrane. Nature Chemical
Biology. 8(6), 583–589.
mla: Irani, Niloufer, et al. “Fluorescent Castasterone Reveals BRI1 Signaling from
the Plasma Membrane.” Nature Chemical Biology, vol. 8, no. 6, Nature Publishing
Group, 2012, pp. 583–89, doi:10.1038/nchembio.958.
short: N. Irani, S. Di Rubbo, E. Mylle, J. Van Den Begin, J. Schneider Pizoń, J.
Hniliková, M. Šíša, D. Buyst, J. Vilarrasa Blasi, A. Szatmári, D. Van Damme, K.
Mishev, M. Codreanu, L. Kohout, M. Strnad, A. Caño Delgado, J. Friml, A. Madder,
E. Russinova, Nature Chemical Biology 8 (2012) 583–589.
date_created: 2018-12-11T12:01:26Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T07:41:07Z
day: '01'
doi: 10.1038/nchembio.958
extern: 1
intvolume: ' 8'
issue: '6'
month: '06'
page: 583 - 589
publication: Nature Chemical Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '3590'
quality_controlled: 0
status: public
title: Fluorescent castasterone reveals BRI1 signaling from the plasma membrane
type: journal_article
volume: 8
year: '2012'
...
---
_id: '3104'
abstract:
- lang: eng
text: |2-
Gradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex interaction of specific influx and efflux carriers that mediate the auxin flow into and out of cells, respectively. Besides these transport proteins, plant-specific polyphenolic compounds knownasflavonols have beenshownto act as endogenous regulators of auxin transport. However, only limited information is available on how flavonol synthesis is developmentally regulated. Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols. The expression of WRKY23 itself is controlled by auxin through the AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 transcriptional response pathway. Our results suggest a model in which WRKY23 is part of a transcriptional feedback loop of auxin on its own transport through local regulation of flavonol biosynthesis.
author:
- first_name: Wim
full_name: Grunewald, Wim
last_name: Grunewald
- first_name: Ive
full_name: De Smet, Ive
last_name: De Smet
- first_name: Daniel
full_name: Lewis, Daniel R
last_name: Lewis
- first_name: Christian
full_name: Löfke, Christian
last_name: Löfke
- first_name: Leentje
full_name: Jansen, Leentje
last_name: Jansen
- first_name: Geert
full_name: Goeminne, Geert
last_name: Goeminne
- first_name: Robin
full_name: Vanden Bossche, Robin
last_name: Vanden Bossche
- first_name: Mansour
full_name: Karimi, Mansour
last_name: Karimi
- first_name: Bert
full_name: De Rybel, Bert
last_name: De Rybel
- first_name: Bartel
full_name: Vanholme, Bartel
last_name: Vanholme
- first_name: Thomas
full_name: Teichmann, Thomas
last_name: Teichmann
- first_name: Wout
full_name: Boerjan, Wout
last_name: Boerjan
- first_name: Marc
full_name: Van Montagu, Marc C
last_name: Van Montagu
- first_name: Godelieve
full_name: Gheysen, Godelieve
last_name: Gheysen
- first_name: Gloria
full_name: Muday, Gloria K
last_name: Muday
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
citation:
ama: Grunewald W, De Smet I, Lewis D, et al. Transcription factor WRKY23 assists
auxin distribution patterns during Arabidopsis root development through local
control on flavonol biosynthesis. PNAS. 2012;109(5):1554-1559. doi:10.1073/pnas.1121134109
apa: Grunewald, W., De Smet, I., Lewis, D., Löfke, C., Jansen, L., Goeminne, G.,
… Beeckman, T. (2012). Transcription factor WRKY23 assists auxin distribution
patterns during Arabidopsis root development through local control on flavonol
biosynthesis. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1121134109
chicago: Grunewald, Wim, Ive De Smet, Daniel Lewis, Christian Löfke, Leentje Jansen,
Geert Goeminne, Robin Vanden Bossche, et al. “Transcription Factor WRKY23 Assists
Auxin Distribution Patterns during Arabidopsis Root Development through Local
Control on Flavonol Biosynthesis.” PNAS. National Academy of Sciences,
2012. https://doi.org/10.1073/pnas.1121134109.
ieee: W. Grunewald et al., “Transcription factor WRKY23 assists auxin distribution
patterns during Arabidopsis root development through local control on flavonol
biosynthesis,” PNAS, vol. 109, no. 5. National Academy of Sciences, pp.
1554–1559, 2012.
ista: Grunewald W, De Smet I, Lewis D, Löfke C, Jansen L, Goeminne G, Vanden Bossche
R, Karimi M, De Rybel B, Vanholme B, Teichmann T, Boerjan W, Van Montagu M, Gheysen
G, Muday G, Friml J, Beeckman T. 2012. Transcription factor WRKY23 assists auxin
distribution patterns during Arabidopsis root development through local control
on flavonol biosynthesis. PNAS. 109(5), 1554–1559.
mla: Grunewald, Wim, et al. “Transcription Factor WRKY23 Assists Auxin Distribution
Patterns during Arabidopsis Root Development through Local Control on Flavonol
Biosynthesis.” PNAS, vol. 109, no. 5, National Academy of Sciences, 2012,
pp. 1554–59, doi:10.1073/pnas.1121134109.
short: W. Grunewald, I. De Smet, D. Lewis, C. Löfke, L. Jansen, G. Goeminne, R.
Vanden Bossche, M. Karimi, B. De Rybel, B. Vanholme, T. Teichmann, W. Boerjan,
M. Van Montagu, G. Gheysen, G. Muday, J. Friml, T. Beeckman, PNAS 109 (2012) 1554–1559.
date_created: 2018-12-11T12:01:24Z
date_published: 2012-01-31T00:00:00Z
date_updated: 2021-01-12T07:41:05Z
day: '31'
doi: 10.1073/pnas.1121134109
extern: 1
intvolume: ' 109'
issue: '5'
month: '01'
page: 1554 - 1559
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3595'
quality_controlled: 0
status: public
title: Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis
root development through local control on flavonol biosynthesis
type: journal_article
volume: 109
year: '2012'
...
---
_id: '3108'
abstract:
- lang: eng
text: The phytohormone auxin acts as a prominent signal, providing, by its local
accumulation or depletion in selected cells, a spatial and temporal reference
for changes in the developmental program. The distribution of auxin depends on
both auxin metabolism (biosynthesis, conjugation and degradation) and cellular
auxin transport. We identified in silico a novel putative auxin transport facilitator
family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required
for auxin-dependent regulation of plant growth by determining the cellular sensitivity
to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic
reticulum and thus auxin availability for nuclear auxin signalling. PILS activity
affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via
intracellular accumulation and metabolism. Our findings reveal that the transport
machinery to compartmentalize auxin within the cell is of an unexpected molecular
complexity and demonstrate this compartmentalization to be functionally important
for a number of developmental processes.
author:
- first_name: Elke
full_name: Barbez, Elke
last_name: Barbez
- first_name: Martin
full_name: Kubeš, Martin
last_name: Kubeš
- first_name: Jakub
full_name: Rolčík, Jakub
last_name: Rolčík
- first_name: Chloe
full_name: Béziat, Chloe
last_name: Béziat
- first_name: Aleš
full_name: Pěnčík, Aleš
last_name: Pěnčík
- first_name: Bangjun
full_name: Wang, Bangjun
last_name: Wang
- first_name: Michel
full_name: Rosquete, Michel Ruiz
last_name: Rosquete
- first_name: Jinsheng
full_name: Zhu, Jinsheng
last_name: Zhu
- first_name: Petre
full_name: Dobrev, Petre I
last_name: Dobrev
- first_name: Yuree
full_name: Lee, Yuree
last_name: Lee
- first_name: Eva
full_name: Zašímalová, Eva
last_name: Zašímalová
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Markus
full_name: Geisler, Markus
last_name: Geisler
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jürgen
full_name: Kleine-Vehn, Jürgen
last_name: Kleine Vehn
citation:
ama: Barbez E, Kubeš M, Rolčík J, et al. A novel putative auxin carrier family regulates
intracellular auxin homeostasis in plants. Nature. 2012;485(7396):119-122.
doi:10.1038/nature11001
apa: Barbez, E., Kubeš, M., Rolčík, J., Béziat, C., Pěnčík, A., Wang, B., … Kleine
Vehn, J. (2012). A novel putative auxin carrier family regulates intracellular
auxin homeostasis in plants. Nature. Nature Publishing Group. https://doi.org/10.1038/nature11001
chicago: Barbez, Elke, Martin Kubeš, Jakub Rolčík, Chloe Béziat, Aleš Pěnčík, Bangjun
Wang, Michel Rosquete, et al. “A Novel Putative Auxin Carrier Family Regulates
Intracellular Auxin Homeostasis in Plants.” Nature. Nature Publishing Group,
2012. https://doi.org/10.1038/nature11001.
ieee: E. Barbez et al., “A novel putative auxin carrier family regulates
intracellular auxin homeostasis in plants,” Nature, vol. 485, no. 7396.
Nature Publishing Group, pp. 119–122, 2012.
ista: Barbez E, Kubeš M, Rolčík J, Béziat C, Pěnčík A, Wang B, Rosquete M, Zhu J,
Dobrev P, Lee Y, Zašímalová E, Petrášek J, Geisler M, Friml J, Kleine Vehn J.
2012. A novel putative auxin carrier family regulates intracellular auxin homeostasis
in plants. Nature. 485(7396), 119–122.
mla: Barbez, Elke, et al. “A Novel Putative Auxin Carrier Family Regulates Intracellular
Auxin Homeostasis in Plants.” Nature, vol. 485, no. 7396, Nature Publishing
Group, 2012, pp. 119–22, doi:10.1038/nature11001.
short: E. Barbez, M. Kubeš, J. Rolčík, C. Béziat, A. Pěnčík, B. Wang, M. Rosquete,
J. Zhu, P. Dobrev, Y. Lee, E. Zašímalová, J. Petrášek, M. Geisler, J. Friml, J.
Kleine Vehn, Nature 485 (2012) 119–122.
date_created: 2018-12-11T12:01:26Z
date_published: 2012-05-03T00:00:00Z
date_updated: 2021-01-12T07:41:07Z
day: '03'
doi: 10.1038/nature11001
extern: 1
intvolume: ' 485'
issue: '7396'
month: '05'
page: 119 - 122
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '3591'
quality_controlled: 0
status: public
title: A novel putative auxin carrier family regulates intracellular auxin homeostasis
in plants
type: journal_article
volume: 485
year: '2012'
...
---
_id: '3106'
abstract:
- lang: eng
text: Cell polarization via asymmetrical distribution of structures or molecules
is essential for diverse cellular functions and development of organisms, but
how polarity is developmentally controlled has been poorly understood. In plants,
the asymmetrical distribution of the PIN-FORMED (PIN) proteins involved in the
cellular efflux of the quintessential phytohormone auxin plays a central role
in developmental patterning, morphogenesis, and differential growth. Recently
we showed that auxin promotes cell interdigitation by activating the Rho family
ROP GTPases in leaf epidermal pavement cells. Here we found that auxin activation
of the ROP2 signaling pathway regulates the asymmetric distribution of PIN1 by
inhibiting its endocytosis. ROP2 inhibits PIN1 endocytosis via the accumulation
of cortical actin microfilaments induced by the ROP2 effector protein RIC4. Our
findings suggest a link between the developmental auxin signal and polar PIN1
distribution via Rho-dependent cytoskeletal reorganization and reveal the conservation
of a design principle for cell polarization that is based on Rho GTPase-mediated
inhibition of endocytosis.
author:
- first_name: Shingo
full_name: Nagawa, Shingo
last_name: Nagawa
- first_name: Tongda
full_name: Xu, Tongda
last_name: Xu
- first_name: Deshu
full_name: Lin, Deshu
last_name: Lin
- first_name: Pankaj
full_name: Dhonukshe, Pankaj
last_name: Dhonukshe
- first_name: Xingxing
full_name: Zhang, Xingxing
last_name: Zhang
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
- first_name: Ying
full_name: Fu, Ying
last_name: Fu
- first_name: Zhenbiao
full_name: Yang, Zhenbiao
last_name: Yang
citation:
ama: Nagawa S, Xu T, Lin D, et al. ROP GTPase-dependent actin microfilaments promote
PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. PLoS
Biology. 2012;10(4). doi:10.1371/journal.pbio.1001299
apa: Nagawa, S., Xu, T., Lin, D., Dhonukshe, P., Zhang, X., Friml, J., … Yang, Z.
(2012). ROP GTPase-dependent actin microfilaments promote PIN1 polarization by
localized inhibition of clathrin-dependent endocytosis. PLoS Biology. Public
Library of Science. https://doi.org/10.1371/journal.pbio.1001299
chicago: Nagawa, Shingo, Tongda Xu, Deshu Lin, Pankaj Dhonukshe, Xingxing Zhang,
Jiří Friml, Ben Scheres, Ying Fu, and Zhenbiao Yang. “ROP GTPase-Dependent Actin
Microfilaments Promote PIN1 Polarization by Localized Inhibition of Clathrin-Dependent
Endocytosis.” PLoS Biology. Public Library of Science, 2012. https://doi.org/10.1371/journal.pbio.1001299.
ieee: S. Nagawa et al., “ROP GTPase-dependent actin microfilaments promote
PIN1 polarization by localized inhibition of clathrin-dependent endocytosis,”
PLoS Biology, vol. 10, no. 4. Public Library of Science, 2012.
ista: Nagawa S, Xu T, Lin D, Dhonukshe P, Zhang X, Friml J, Scheres B, Fu Y, Yang
Z. 2012. ROP GTPase-dependent actin microfilaments promote PIN1 polarization by
localized inhibition of clathrin-dependent endocytosis. PLoS Biology. 10(4).
mla: Nagawa, Shingo, et al. “ROP GTPase-Dependent Actin Microfilaments Promote PIN1
Polarization by Localized Inhibition of Clathrin-Dependent Endocytosis.” PLoS
Biology, vol. 10, no. 4, Public Library of Science, 2012, doi:10.1371/journal.pbio.1001299.
short: S. Nagawa, T. Xu, D. Lin, P. Dhonukshe, X. Zhang, J. Friml, B. Scheres, Y.
Fu, Z. Yang, PLoS Biology 10 (2012).
date_created: 2018-12-11T12:01:25Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2021-01-12T07:41:06Z
day: '01'
doi: 10.1371/journal.pbio.1001299
extern: 1
intvolume: ' 10'
issue: '4'
month: '04'
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '3593'
quality_controlled: 0
status: public
title: ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized
inhibition of clathrin-dependent endocytosis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 10
year: '2012'
...
---
_id: '3107'
author:
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: 'Vanneste S, Friml J. Plant Signaling: Deconstructing Auxin Sensing.
Vol 8. Nature Publishing Group; 2012:415-416. doi:10.1038/nchembio.943'
apa: 'Vanneste, S., & Friml, J. (2012). Plant signaling: Deconstructing auxin
sensing. Nature Chemical Biology (Vol. 8, pp. 415–416). Nature Publishing
Group. https://doi.org/10.1038/nchembio.943'
chicago: 'Vanneste, Steffen, and Jiří Friml. Plant Signaling: Deconstructing
Auxin Sensing. Nature Chemical Biology. Vol. 8. Nature Publishing Group,
2012. https://doi.org/10.1038/nchembio.943.'
ieee: 'S. Vanneste and J. Friml, Plant signaling: Deconstructing auxin sensing,
vol. 8, no. 5. Nature Publishing Group, 2012, pp. 415–416.'
ista: 'Vanneste S, Friml J. 2012. Plant signaling: Deconstructing auxin sensing,
Nature Publishing Group,p.'
mla: 'Vanneste, Steffen, and Jiří Friml. “Plant Signaling: Deconstructing Auxin
Sensing.” Nature Chemical Biology, vol. 8, no. 5, Nature Publishing Group,
2012, pp. 415–16, doi:10.1038/nchembio.943.'
short: 'S. Vanneste, J. Friml, Plant Signaling: Deconstructing Auxin Sensing, Nature
Publishing Group, 2012.'
date_created: 2018-12-11T12:01:26Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T07:41:06Z
day: '01'
doi: 10.1038/nchembio.943
extern: '1'
intvolume: ' 8'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 415 - 416
publication: Nature Chemical Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '3592'
quality_controlled: '1'
status: public
title: 'Plant signaling: Deconstructing auxin sensing'
type: other_academic_publication
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2012'
...
---
_id: '3119'
abstract:
- lang: eng
text: "We present an approach for artist-directed animation of liquids using multiple
levels of control over the simulation, ranging from the overall tracking of desired
shapes to highly detailed secondary effects such as dripping streams, separating
sheets of fluid, surface waves and ripples. The first portion of our technique
is a volume preserving morph that allows the animator to produce a plausible fluid-like
motion from a sparse set of control meshes. By rasterizing the resulting control
meshes onto the simulation grid, the mesh velocities act as boundary conditions
during the projection step of the fluid simulation. We can then blend this motion
together with uncontrolled fluid velocities to achieve a more relaxed control
over the fluid that captures natural inertial effects. Our method can produce
highly detailed liquid surfaces with control over sub-grid details by using a
mesh-based surface tracker on top of a coarse grid-based fluid simulation. We
can create ripples and waves on the fluid surface attracting the surface mesh
to the control mesh with spring-like forces and also by running a wave simulation
over the surface mesh. Our video results demonstrate how our control scheme can
be used to create animated characters and shapes that are made of water.\r\n"
acknowledgement: This work was partially funded by NSF grants CCF-0811485 and IIS-1130934.
We would like to thank Scanline VFX for additional funding. We would like to thank
Jie Tan as well as our anonymous reviewers for their useful suggestions and feedback.
author:
- first_name: Karthik
full_name: Raveendran, Karthik
last_name: Raveendran
- first_name: Nils
full_name: Thuerey, Nils
last_name: Thuerey
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
- first_name: Greg
full_name: Turk, Greg
last_name: Turk
citation:
ama: 'Raveendran K, Thuerey N, Wojtan C, Turk G. Controlling liquids using meshes.
In: Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation.
ACM; 2012:255-264.'
apa: 'Raveendran, K., Thuerey, N., Wojtan, C., & Turk, G. (2012). Controlling
liquids using meshes. In Proceedings of the ACM SIGGRAPH/Eurographics Symposium
on Computer Animation (pp. 255–264). Aire-la-Ville, Switzerland: ACM.'
chicago: Raveendran, Karthik, Nils Thuerey, Chris Wojtan, and Greg Turk. “Controlling
Liquids Using Meshes.” In Proceedings of the ACM SIGGRAPH/Eurographics Symposium
on Computer Animation, 255–64. ACM, 2012.
ieee: K. Raveendran, N. Thuerey, C. Wojtan, and G. Turk, “Controlling liquids using
meshes,” in Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer
Animation, Aire-la-Ville, Switzerland, 2012, pp. 255–264.
ista: 'Raveendran K, Thuerey N, Wojtan C, Turk G. 2012. Controlling liquids using
meshes. Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation.
SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation, 255–264.'
mla: Raveendran, Karthik, et al. “Controlling Liquids Using Meshes.” Proceedings
of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation, ACM, 2012,
pp. 255–64.
short: K. Raveendran, N. Thuerey, C. Wojtan, G. Turk, in:, Proceedings of the ACM
SIGGRAPH/Eurographics Symposium on Computer Animation, ACM, 2012, pp. 255–264.
conference:
end_date: 2012-07-31
location: Aire-la-Ville, Switzerland
name: 'SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation'
start_date: 2012-07-29
date_created: 2018-12-11T12:01:30Z
date_published: 2012-07-29T00:00:00Z
date_updated: 2023-02-23T11:13:07Z
day: '29'
ddc:
- '000'
department:
- _id: ChWo
file:
- access_level: open_access
checksum: babda64c24cf90a4d05ae86d712bed08
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:23Z
date_updated: 2020-07-14T12:46:00Z
file_id: '4877'
file_name: IST-2016-600-v1+1_ControllingLiquids_Preprint.pdf
file_size: 4939370
relation: main_file
file_date_updated: 2020-07-14T12:46:00Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 255 - 264
publication: Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation
publication_status: published
publisher: ACM
publist_id: '3580'
pubrep_id: '600'
quality_controlled: '1'
related_material:
link:
- relation: table_of_contents
url: http://dl.acm.org/citation.cfm?id=2422393
scopus_import: 1
status: public
title: Controlling liquids using meshes
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '3118'
abstract:
- lang: eng
text: We present a method for recovering a temporally coherent, deforming triangle
mesh with arbitrarily changing topology from an incoherent sequence of static
closed surfaces. We solve this problem using the surface geometry alone, without
any prior information like surface templates or velocity fields. Our system combines
a proven strategy for triangle mesh improvement, a robust multi-resolution non-rigid
registration routine, and a reliable technique for changing surface mesh topology.
We also introduce a novel topological constraint enforcement algorithm to ensure
that the output and input always have similar topology. We apply our technique
to a series of diverse input data from video reconstructions, physics simulations,
and artistic morphs. The structured output of our algorithm allows us to efficiently
track information like colors and displacement maps, recover velocity information,
and solve PDEs on the mesh as a post process.
acknowledgement: "This work is supported by the SNF fellowship PBEZP2-134464.\r\nWe
would like to thank Xiaochen Hu for implementing mesh con- version tools, Duygu
Ceylan for helping with the rendering, and Art Tevs for the human performance data
comparison. We also thank Nils Thuerey and Christopher Batty for helpful discussions. "
alternative_title:
- SIGGRAPH
article_number: '53'
article_processing_charge: No
article_type: original
author:
- first_name: Morten
full_name: Bojsen-Hansen, Morten
id: 439F0C8C-F248-11E8-B48F-1D18A9856A87
last_name: Bojsen-Hansen
orcid: 0000-0002-4417-3224
- first_name: Hao
full_name: Li, Hao
last_name: Li
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Bojsen-Hansen M, Li H, Wojtan C. Tracking surfaces with evolving topology.
ACM Transactions on Graphics. 2012;31(4). doi:10.1145/2185520.2185549
apa: Bojsen-Hansen, M., Li, H., & Wojtan, C. (2012). Tracking surfaces with
evolving topology. ACM Transactions on Graphics. ACM. https://doi.org/10.1145/2185520.2185549
chicago: Bojsen-Hansen, Morten, Hao Li, and Chris Wojtan. “Tracking Surfaces with
Evolving Topology.” ACM Transactions on Graphics. ACM, 2012. https://doi.org/10.1145/2185520.2185549.
ieee: M. Bojsen-Hansen, H. Li, and C. Wojtan, “Tracking surfaces with evolving topology,”
ACM Transactions on Graphics, vol. 31, no. 4. ACM, 2012.
ista: Bojsen-Hansen M, Li H, Wojtan C. 2012. Tracking surfaces with evolving topology.
ACM Transactions on Graphics. 31(4), 53.
mla: Bojsen-Hansen, Morten, et al. “Tracking Surfaces with Evolving Topology.” ACM
Transactions on Graphics, vol. 31, no. 4, 53, ACM, 2012, doi:10.1145/2185520.2185549.
short: M. Bojsen-Hansen, H. Li, C. Wojtan, ACM Transactions on Graphics 31 (2012).
date_created: 2018-12-11T12:01:29Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2022-05-24T08:21:11Z
day: '01'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/2185520.2185549
file:
- access_level: open_access
checksum: 1e219c5bf4e5552c1290c62eefa5cd60
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:37Z
date_updated: 2020-07-14T12:46:00Z
file_id: '5359'
file_name: IST-2016-602-v1+1_topoReg.pdf
file_size: 44538518
relation: main_file
file_date_updated: 2020-07-14T12:46:00Z
has_accepted_license: '1'
intvolume: ' 31'
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '3581'
pubrep_id: '602'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tracking surfaces with evolving topology
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2012'
...
---
_id: '3122'
abstract:
- lang: eng
text: 'Since Darwin''s pioneering research on plant reproductive biology (e.g. Darwin
1877), understanding the mechanisms maintaining the diverse sexual strategies
of plants has remained an important challenge for evolutionary biologists. In
some species, populations are sexually polymorphic and contain two or more mating
morphs (sex phenotypes). Differences in morphology or phenology among the morphs
influence patterns of non-random mating. In these populations, negative frequency-dependent
selection arising from disassortative (intermorph) mating is usually required
for the evolutionary maintenance of sexual polymorphism, but few studies have
demonstrated the required patterns of non-random mating. In the current issue
of Molecular Ecology, Shang (2012) make an important contribution to our understanding
of how disassortative mating influences sex phenotype ratios in Acer pictum subsp.
mono (painted maple), a heterodichogamous, deciduous tree of eastern China. They
monitored sex expression in 97 adults and used paternity analysis of open-pollinated
seed to examine disassortative mating among three sex phenotypes. Using a deterministic
''pollen transfer'' model, Shang et al. present convincing evidence that differences
in the degree of disassortative mating in progeny arrays of the sex phenotypes
can explain their uneven frequencies in the adult population. This study provides
a useful example of how the deployment of genetic markers, demographic monitoring
and modelling can be integrated to investigate the maintenance of sexual diversity
in plants. '
author:
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Spencer
full_name: Barrett, Spencer
last_name: Barrett
citation:
ama: Field D, Barrett S. Disassortative mating and the maintenance of sexual polymorphism
in painted maple. Molecular Ecology. 2012;21(15):3640-3643. doi:10.1111/j.1365-294X.2012.05643.x
apa: Field, D., & Barrett, S. (2012). Disassortative mating and the maintenance
of sexual polymorphism in painted maple. Molecular Ecology. Wiley-Blackwell.
https://doi.org/10.1111/j.1365-294X.2012.05643.x
chicago: Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance
of Sexual Polymorphism in Painted Maple.” Molecular Ecology. Wiley-Blackwell,
2012. https://doi.org/10.1111/j.1365-294X.2012.05643.x.
ieee: D. Field and S. Barrett, “Disassortative mating and the maintenance of sexual
polymorphism in painted maple,” Molecular Ecology, vol. 21, no. 15. Wiley-Blackwell,
pp. 3640–3643, 2012.
ista: Field D, Barrett S. 2012. Disassortative mating and the maintenance of sexual
polymorphism in painted maple. Molecular Ecology. 21(15), 3640–3643.
mla: Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance
of Sexual Polymorphism in Painted Maple.” Molecular Ecology, vol. 21, no.
15, Wiley-Blackwell, 2012, pp. 3640–43, doi:10.1111/j.1365-294X.2012.05643.x.
short: D. Field, S. Barrett, Molecular Ecology 21 (2012) 3640–3643.
date_created: 2018-12-11T12:01:31Z
date_published: 2012-08-01T00:00:00Z
date_updated: 2021-01-12T07:41:13Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/j.1365-294X.2012.05643.x
intvolume: ' 21'
issue: '15'
language:
- iso: eng
month: '08'
oa_version: None
page: 3640 - 3643
publication: Molecular Ecology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3577'
quality_controlled: '1'
scopus_import: 1
status: public
title: Disassortative mating and the maintenance of sexual polymorphism in painted
maple
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2012'
...
---
_id: '3121'
abstract:
- lang: eng
text: Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger
action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+)
regulates spontaneous transmission is unclear. We found that VACCs are the major
physiological triggers for spontaneous release at mouse neocortical inhibitory
synapses. Moreover, despite the absence of a synchronizing action potential, we
found that spontaneous fusion of a GABA-containing vesicle required the activation
of multiple tightly coupled VACCs of variable type.
acknowledgement: "The work was supported by the US National Institutes of Health (DA027110
and GM097433) and OCTRI. C.W. and N.P.V. were supported by a grant from the National
Heart, Lung, and Blood Institute (T32HL033808).\r\nWe thank M. Andresen and K. Khodakhah
for helpful comments. "
author:
- first_name: Courtney
full_name: Williams, Courtney
last_name: Williams
- first_name: Wenyan
full_name: Chen, Wenyan
last_name: Chen
- first_name: Chia
full_name: Lee, Chia
last_name: Lee
- first_name: Daniel
full_name: Yaeger, Daniel
last_name: Yaeger
- first_name: Nicholas
full_name: Vyleta, Nicholas
id: 36C4978E-F248-11E8-B48F-1D18A9856A87
last_name: Vyleta
- first_name: Stephen
full_name: Smith, Stephen
last_name: Smith
citation:
ama: Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. Coactivation of multiple
tightly coupled calcium channels triggers spontaneous release of GABA. Nature
Neuroscience. 2012;15(9):1195-1197. doi:10.1038/nn.3162
apa: Williams, C., Chen, W., Lee, C., Yaeger, D., Vyleta, N., & Smith, S. (2012).
Coactivation of multiple tightly coupled calcium channels triggers spontaneous
release of GABA. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3162
chicago: Williams, Courtney, Wenyan Chen, Chia Lee, Daniel Yaeger, Nicholas Vyleta,
and Stephen Smith. “Coactivation of Multiple Tightly Coupled Calcium Channels
Triggers Spontaneous Release of GABA.” Nature Neuroscience. Nature Publishing
Group, 2012. https://doi.org/10.1038/nn.3162.
ieee: C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, and S. Smith, “Coactivation
of multiple tightly coupled calcium channels triggers spontaneous release of GABA,”
Nature Neuroscience, vol. 15, no. 9. Nature Publishing Group, pp. 1195–1197,
2012.
ista: Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. 2012. Coactivation
of multiple tightly coupled calcium channels triggers spontaneous release of GABA.
Nature Neuroscience. 15(9), 1195–1197.
mla: Williams, Courtney, et al. “Coactivation of Multiple Tightly Coupled Calcium
Channels Triggers Spontaneous Release of GABA.” Nature Neuroscience, vol.
15, no. 9, Nature Publishing Group, 2012, pp. 1195–97, doi:10.1038/nn.3162.
short: C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, S. Smith, Nature Neuroscience
15 (2012) 1195–1197.
date_created: 2018-12-11T12:01:30Z
date_published: 2012-09-01T00:00:00Z
date_updated: 2021-01-12T07:41:12Z
day: '01'
department:
- _id: PeJo
doi: 10.1038/nn.3162
external_id:
pmid:
- '22842148'
intvolume: ' 15'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/
month: '09'
oa: 1
oa_version: Submitted Version
page: 1195 - 1197
pmid: 1
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3578'
quality_controlled: '1'
scopus_import: 1
status: public
title: Coactivation of multiple tightly coupled calcium channels triggers spontaneous
release of GABA
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2012'
...
---
_id: '3120'
abstract:
- lang: eng
text: We introduce a strategy based on Kustin-Miller unprojection that allows us
to construct many hundreds of Gorenstein codimension 4 ideals with 9 × 16 resolutions
(that is, nine equations and sixteen first syzygies). Our two basic games are
called Tom and Jerry; the main application is the biregular construction of most
of the anticanonically polarised Mori Fano 3-folds of Altinok's thesis. There
are 115 cases whose numerical data (in effect, the Hilbert series) allow a Type
I projection. In every case, at least one Tom and one Jerry construction works,
providing at least two deformation families of quasismooth Fano 3-folds having
the same numerics but different topology. © 2012 Copyright Foundation Compositio
Mathematica.
acknowledgement: This research is supported by the Korean Government WCU Grant R33-2008-000-10101-0.
author:
- first_name: Gavin
full_name: Brown, Gavin
last_name: Brown
- first_name: Michael
full_name: Kerber, Michael
id: 36E4574A-F248-11E8-B48F-1D18A9856A87
last_name: Kerber
orcid: 0000-0002-8030-9299
- first_name: Miles
full_name: Reid, Miles
last_name: Reid
citation:
ama: Brown G, Kerber M, Reid M. Fano 3 folds in codimension 4 Tom and Jerry Part
I. Compositio Mathematica. 2012;148(4):1171-1194. doi:10.1112/S0010437X11007226
apa: Brown, G., Kerber, M., & Reid, M. (2012). Fano 3 folds in codimension 4
Tom and Jerry Part I. Compositio Mathematica. Cambridge University Press.
https://doi.org/10.1112/S0010437X11007226
chicago: Brown, Gavin, Michael Kerber, and Miles Reid. “Fano 3 Folds in Codimension
4 Tom and Jerry Part I.” Compositio Mathematica. Cambridge University Press,
2012. https://doi.org/10.1112/S0010437X11007226.
ieee: G. Brown, M. Kerber, and M. Reid, “Fano 3 folds in codimension 4 Tom and Jerry
Part I,” Compositio Mathematica, vol. 148, no. 4. Cambridge University
Press, pp. 1171–1194, 2012.
ista: Brown G, Kerber M, Reid M. 2012. Fano 3 folds in codimension 4 Tom and Jerry
Part I. Compositio Mathematica. 148(4), 1171–1194.
mla: Brown, Gavin, et al. “Fano 3 Folds in Codimension 4 Tom and Jerry Part I.”
Compositio Mathematica, vol. 148, no. 4, Cambridge University Press, 2012,
pp. 1171–94, doi:10.1112/S0010437X11007226.
short: G. Brown, M. Kerber, M. Reid, Compositio Mathematica 148 (2012) 1171–1194.
date_created: 2018-12-11T12:01:30Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:12Z
day: '01'
department:
- _id: HeEd
doi: 10.1112/S0010437X11007226
intvolume: ' 148'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1009.4313
month: '07'
oa: 1
oa_version: Preprint
page: 1171 - 1194
publication: Compositio Mathematica
publication_status: published
publisher: Cambridge University Press
publist_id: '3579'
quality_controlled: '1'
scopus_import: 1
status: public
title: Fano 3 folds in codimension 4 Tom and Jerry Part I
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 148
year: '2012'
...
---
_id: '3117'
abstract:
- lang: eng
text: We consider the problem of minimizing a function represented as a sum of submodular
terms. We assume each term allows an efficient computation of exchange capacities.
This holds, for example, for terms depending on a small number of variables, or
for certain cardinality-dependent terms. A naive application of submodular minimization
algorithms would not exploit the existence of specialized exchange capacity subroutines
for individual terms. To overcome this, we cast the problem as a submodular flow
(SF) problem in an auxiliary graph in such a way that applying most existing SF
algorithms would rely only on these subroutines. We then explore in more detail
Iwata's capacity scaling approach for submodular flows (Iwata 1997 [19]). In particular,
we show how to improve its complexity in the case when the function contains cardinality-dependent
terms.
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
citation:
ama: Kolmogorov V. Minimizing a sum of submodular functions. Discrete Applied
Mathematics. 2012;160(15):2246-2258. doi:10.1016/j.dam.2012.05.025
apa: Kolmogorov, V. (2012). Minimizing a sum of submodular functions. Discrete
Applied Mathematics. Elsevier. https://doi.org/10.1016/j.dam.2012.05.025
chicago: Kolmogorov, Vladimir. “Minimizing a Sum of Submodular Functions.” Discrete
Applied Mathematics. Elsevier, 2012. https://doi.org/10.1016/j.dam.2012.05.025.
ieee: V. Kolmogorov, “Minimizing a sum of submodular functions,” Discrete Applied
Mathematics, vol. 160, no. 15. Elsevier, pp. 2246–2258, 2012.
ista: Kolmogorov V. 2012. Minimizing a sum of submodular functions. Discrete Applied
Mathematics. 160(15), 2246–2258.
mla: Kolmogorov, Vladimir. “Minimizing a Sum of Submodular Functions.” Discrete
Applied Mathematics, vol. 160, no. 15, Elsevier, 2012, pp. 2246–58, doi:10.1016/j.dam.2012.05.025.
short: V. Kolmogorov, Discrete Applied Mathematics 160 (2012) 2246–2258.
date_created: 2018-12-11T12:01:29Z
date_published: 2012-10-01T00:00:00Z
date_updated: 2021-01-12T07:41:11Z
day: '01'
department:
- _id: VlKo
doi: 10.1016/j.dam.2012.05.025
intvolume: ' 160'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1006.1990
month: '10'
oa: 1
oa_version: Preprint
page: 2246 - 2258
publication: Discrete Applied Mathematics
publication_status: published
publisher: Elsevier
publist_id: '3582'
quality_controlled: '1'
scopus_import: 1
status: public
title: Minimizing a sum of submodular functions
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2012'
...
---
_id: '3131'
abstract:
- lang: eng
text: 'In large populations, many beneficial mutations may be simultaneously available
and may compete with one another, slowing adaptation. By finding the probability
of fixation of a favorable allele in a simple model of a haploid sexual population,
we find limits to the rate of adaptive substitution, Λ, that depend on simple
parameter combinations. When variance in fitness is low and linkage is loose,
the baseline rate of substitution is Λ 0=2NU〈s〉 is the population size, U is the
rate of beneficial mutations per genome, and 〈s〉 is their mean selective advantage.
Heritable variance ν in log fitness due to unlinked loci reduces Λ by e -4ν under
polygamy and e -8ν under monogamy. With a linear genetic map of length R Morgans,
interference is yet stronger. We use a scaling argument to show that the density
of adaptive substitutions depends on s, N, U, and R only through the baseline
density: Λ/R=F(Λ 0/R). Under the approximation that the interference due to different
sweeps adds up, we show that Λ/R~(Λ 0/R)/(1+2Λ 0/R), implying that interference
prevents the rate of adaptive substitution from exceeding one per centimorgan
per 200 generations. Simulations and numerical calculations confirm the scaling
argument and confirm the additive approximation for Λ 0/R 1; for higher Λ 0/R,
the rate of adaptation grows above R/2, but only very slowly. We also consider
the effect of sweeps on neutral diversity and show that, while even occasional
sweeps can greatly reduce neutral diversity, this effect saturates as sweeps become
more common-diversity can be maintained even in populations experiencing very
strong interference. Our results indicate that for some organisms the rate of
adaptive substitution may be primarily recombination-limited, depending only weakly
on the mutation supply and the strength of selection.'
acknowledgement: "The work was funded by ERC grant 250152.\r\nWe thank B. Charlesworth,
O. Hallatschek, W. G. Hill, R. A. Neher, S. P. Otto, and the anonymous reviewers
for their helpful suggestions."
article_number: e1002740
author:
- first_name: Daniel
full_name: Weissman, Daniel
id: 2D0CE020-F248-11E8-B48F-1D18A9856A87
last_name: Weissman
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Weissman D, Barton NH. Limits to the rate of adaptive substitution in sexual
populations. PLoS Genetics. 2012;8(6). doi:10.1371/journal.pgen.1002740
apa: Weissman, D., & Barton, N. H. (2012). Limits to the rate of adaptive substitution
in sexual populations. PLoS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1002740
chicago: Weissman, Daniel, and Nicholas H Barton. “Limits to the Rate of Adaptive
Substitution in Sexual Populations.” PLoS Genetics. Public Library of Science,
2012. https://doi.org/10.1371/journal.pgen.1002740.
ieee: D. Weissman and N. H. Barton, “Limits to the rate of adaptive substitution
in sexual populations,” PLoS Genetics, vol. 8, no. 6. Public Library of
Science, 2012.
ista: Weissman D, Barton NH. 2012. Limits to the rate of adaptive substitution in
sexual populations. PLoS Genetics. 8(6), e1002740.
mla: Weissman, Daniel, and Nicholas H. Barton. “Limits to the Rate of Adaptive Substitution
in Sexual Populations.” PLoS Genetics, vol. 8, no. 6, e1002740, Public
Library of Science, 2012, doi:10.1371/journal.pgen.1002740.
short: D. Weissman, N.H. Barton, PLoS Genetics 8 (2012).
date_created: 2018-12-11T12:01:34Z
date_published: 2012-06-07T00:00:00Z
date_updated: 2021-01-12T07:41:17Z
day: '07'
ddc:
- '570'
- '576'
department:
- _id: NiBa
doi: 10.1371/journal.pgen.1002740
ec_funded: 1
file:
- access_level: open_access
checksum: 729a4becda7d786c4c3db8f9a1f77953
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:00Z
date_updated: 2020-07-14T12:46:01Z
file_id: '4659'
file_name: IST-2013-114-v1+1_WeissmanBarton2012.pdf
file_size: 1284801
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '3566'
pubrep_id: '114'
quality_controlled: '1'
scopus_import: 1
status: public
title: Limits to the rate of adaptive substitution in sexual populations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2012'
...
---
_id: '3130'
abstract:
- lang: eng
text: 'Essential genes code for fundamental cellular functions required for the
viability of an organism. For this reason, essential genes are often highly conserved
across organisms. However, this is not always the case: orthologues of genes that
are essential in one organism are sometimes not essential in other organisms or
are absent from their genomes. This suggests that, in the course of evolution,
essential genes can be rendered nonessential. How can a gene become non-essential?
Here we used genetic manipulation to deplete the products of 26 different essential
genes in Escherichia coli. This depletion results in a lethal phenotype, which
could often be rescued by the overexpression of a non-homologous, non-essential
gene, most likely through replacement of the essential function. We also show
that, in a smaller number of cases, the essential genes can be fully deleted from
the genome, suggesting that complete functional replacement is possible. Finally,
we show that essential genes whose function can be replaced in the laboratory
are more likely to be non-essential or not present in other taxa. These results
are consistent with the notion that patterns of evolutionary conservation of essential
genes are influenced by their compensability-that is, by how easily they can be
functionally replaced, for example through increased expression of other genes.'
acknowledgement: We thank Alex Boehm for discussions and comments.
article_number: e1002803
author:
- first_name: Tobias
full_name: Bergmiller, Tobias
id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
last_name: Bergmiller
orcid: 0000-0001-5396-4346
- first_name: Martin
full_name: Ackermann, Martin
last_name: Ackermann
- first_name: Olin
full_name: Silander, Olin
last_name: Silander
citation:
ama: Bergmiller T, Ackermann M, Silander O. Patterns of evolutionary conservation
of essential genes correlate with their compensability. PLoS Genetics.
2012;8(6). doi:10.1371/journal.pgen.1002803
apa: Bergmiller, T., Ackermann, M., & Silander, O. (2012). Patterns of evolutionary
conservation of essential genes correlate with their compensability. PLoS Genetics.
Public Library of Science. https://doi.org/10.1371/journal.pgen.1002803
chicago: Bergmiller, Tobias, Martin Ackermann, and Olin Silander. “Patterns of Evolutionary
Conservation of Essential Genes Correlate with Their Compensability.” PLoS
Genetics. Public Library of Science, 2012. https://doi.org/10.1371/journal.pgen.1002803.
ieee: T. Bergmiller, M. Ackermann, and O. Silander, “Patterns of evolutionary conservation
of essential genes correlate with their compensability,” PLoS Genetics,
vol. 8, no. 6. Public Library of Science, 2012.
ista: Bergmiller T, Ackermann M, Silander O. 2012. Patterns of evolutionary conservation
of essential genes correlate with their compensability. PLoS Genetics. 8(6), e1002803.
mla: Bergmiller, Tobias, et al. “Patterns of Evolutionary Conservation of Essential
Genes Correlate with Their Compensability.” PLoS Genetics, vol. 8, no.
6, e1002803, Public Library of Science, 2012, doi:10.1371/journal.pgen.1002803.
short: T. Bergmiller, M. Ackermann, O. Silander, PLoS Genetics 8 (2012).
date_created: 2018-12-11T12:01:34Z
date_published: 2012-06-28T00:00:00Z
date_updated: 2021-01-12T07:41:16Z
day: '28'
ddc:
- '576'
department:
- _id: CaGu
doi: 10.1371/journal.pgen.1002803
file:
- access_level: open_access
checksum: f8506fb579eda6fc5613ba9bf421b86a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:52Z
date_updated: 2020-07-14T12:46:01Z
file_id: '4973'
file_name: IST-2015-386-v1+1_journal.pgen.1002803.pdf
file_size: 2674138
relation: main_file
file_date_updated: 2020-07-14T12:46:01Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '3567'
pubrep_id: '386'
quality_controlled: '1'
scopus_import: 1
status: public
title: Patterns of evolutionary conservation of essential genes correlate with their
compensability
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2012'
...
---
_id: '3136'
abstract:
- lang: eng
text: 'Continuous-time Markov chains (CTMC) with their rich theory and efficient
simulation algorithms have been successfully used in modeling stochastic processes
in diverse areas such as computer science, physics, and biology. However, systems
that comprise non-instantaneous events cannot be accurately and efficiently modeled
with CTMCs. In this paper we define delayed CTMCs, an extension of CTMCs that
allows for the specification of a lower bound on the time interval between an
event''s initiation and its completion, and we propose an algorithm for the computation
of their behavior. Our algorithm effectively decomposes the computation into two
stages: a pure CTMC governs event initiations while a deterministic process guarantees
lower bounds on event completion times. Furthermore, from the nature of delayed
CTMCs, we obtain a parallelized version of our algorithm. We use our formalism
to model genetic regulatory circuits (biological systems where delayed events
are common) and report on the results of our numerical algorithm as run on a cluster.
We compare performance and accuracy of our results with results obtained by using
pure CTMCs. © 2012 Springer-Verlag.'
acknowledgement: This work was supported by the ERC Advanced Investigator grant on
Quantitative Reactive Modeling (QUAREM) and by the Swiss National Science Foundation.
alternative_title:
- LNCS
author:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Ashutosh
full_name: Gupta, Ashutosh
id: 335E5684-F248-11E8-B48F-1D18A9856A87
last_name: Gupta
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Maria
full_name: Mateescu, Maria
id: 3B43276C-F248-11E8-B48F-1D18A9856A87
last_name: Mateescu
- first_name: Ali
full_name: Sezgin, Ali
id: 4C7638DA-F248-11E8-B48F-1D18A9856A87
last_name: Sezgin
citation:
ama: 'Guet CC, Gupta A, Henzinger TA, Mateescu M, Sezgin A. Delayed continuous time
Markov chains for genetic regulatory circuits. In: Vol 7358. Springer; 2012:294-309.
doi:10.1007/978-3-642-31424-7_24'
apa: 'Guet, C. C., Gupta, A., Henzinger, T. A., Mateescu, M., & Sezgin, A. (2012).
Delayed continuous time Markov chains for genetic regulatory circuits (Vol. 7358,
pp. 294–309). Presented at the CAV: Computer Aided Verification, Berkeley, CA,
USA: Springer. https://doi.org/10.1007/978-3-642-31424-7_24'
chicago: Guet, Calin C, Ashutosh Gupta, Thomas A Henzinger, Maria Mateescu, and
Ali Sezgin. “Delayed Continuous Time Markov Chains for Genetic Regulatory Circuits,”
7358:294–309. Springer, 2012. https://doi.org/10.1007/978-3-642-31424-7_24.
ieee: 'C. C. Guet, A. Gupta, T. A. Henzinger, M. Mateescu, and A. Sezgin, “Delayed
continuous time Markov chains for genetic regulatory circuits,” presented at the
CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 294–309.'
ista: 'Guet CC, Gupta A, Henzinger TA, Mateescu M, Sezgin A. 2012. Delayed continuous
time Markov chains for genetic regulatory circuits. CAV: Computer Aided Verification,
LNCS, vol. 7358, 294–309.'
mla: Guet, Calin C., et al. Delayed Continuous Time Markov Chains for Genetic
Regulatory Circuits. Vol. 7358, Springer, 2012, pp. 294–309, doi:10.1007/978-3-642-31424-7_24.
short: C.C. Guet, A. Gupta, T.A. Henzinger, M. Mateescu, A. Sezgin, in:, Springer,
2012, pp. 294–309.
conference:
end_date: 2012-07-13
location: Berkeley, CA, USA
name: 'CAV: Computer Aided Verification'
start_date: 2012-07-07
date_created: 2018-12-11T12:01:36Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:18Z
day: '01'
department:
- _id: CaGu
- _id: ToHe
doi: 10.1007/978-3-642-31424-7_24
ec_funded: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 294 - 309
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
publication_status: published
publisher: Springer
publist_id: '3561'
quality_controlled: '1'
scopus_import: 1
status: public
title: Delayed continuous time Markov chains for genetic regulatory circuits
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: '7358 '
year: '2012'
...
---
_id: '3135'
abstract:
- lang: eng
text: 'We introduce consumption games, a model for discrete interactive system with
multiple resources that are consumed or reloaded independently. More precisely,
a consumption game is a finite-state graph where each transition is labeled by
a vector of resource updates, where every update is a non-positive number or ω.
The ω updates model the reloading of a given resource. Each vertex belongs either
to player □ or player ◇, where the aim of player □ is to play so that the resources
are never exhausted. We consider several natural algorithmic problems about consumption
games, and show that although these problems are computationally hard in general,
they are solvable in polynomial time for every fixed number of resource types
(i.e., the dimension of the update vectors) and bounded resource updates. '
acknowledgement: 'Tomas Brazdil, Antonin Kucera, and Petr Novotny are supported by
the Czech Science Foundation, grant No. P202/10/1469. Krishnendu Chatterjee is supported
by the FWF (Austrian Science Fund) NFN Grant No S11407-N23 (RiSE) and ERC Start
grant (279307: Graph Games).'
alternative_title:
- LNCS
author:
- first_name: Brázdil
full_name: Brázdil, Brázdil
last_name: Brázdil
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Antonín
full_name: Kučera, Antonín
last_name: Kučera
- first_name: Petr
full_name: Novotny, Petr
id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
last_name: Novotny
citation:
ama: 'Brázdil B, Chatterjee K, Kučera A, Novotný P. Efficient controller synthesis
for consumption games with multiple resource types. In: Vol 7358. Springer; 2012:23-38.
doi:10.1007/978-3-642-31424-7_8'
apa: 'Brázdil, B., Chatterjee, K., Kučera, A., & Novotný, P. (2012). Efficient
controller synthesis for consumption games with multiple resource types (Vol.
7358, pp. 23–38). Presented at the CAV: Computer Aided Verification, Berkeley,
CA, USA: Springer. https://doi.org/10.1007/978-3-642-31424-7_8'
chicago: Brázdil, Brázdil, Krishnendu Chatterjee, Antonín Kučera, and Petr Novotný.
“Efficient Controller Synthesis for Consumption Games with Multiple Resource Types,”
7358:23–38. Springer, 2012. https://doi.org/10.1007/978-3-642-31424-7_8.
ieee: 'B. Brázdil, K. Chatterjee, A. Kučera, and P. Novotný, “Efficient controller
synthesis for consumption games with multiple resource types,” presented at the
CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 23–38.'
ista: 'Brázdil B, Chatterjee K, Kučera A, Novotný P. 2012. Efficient controller
synthesis for consumption games with multiple resource types. CAV: Computer Aided
Verification, LNCS, vol. 7358, 23–38.'
mla: Brázdil, Brázdil, et al. Efficient Controller Synthesis for Consumption
Games with Multiple Resource Types. Vol. 7358, Springer, 2012, pp. 23–38,
doi:10.1007/978-3-642-31424-7_8.
short: B. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, in:, Springer, 2012, pp.
23–38.
conference:
end_date: 2012-07-13
location: Berkeley, CA, USA
name: 'CAV: Computer Aided Verification'
start_date: 2012-07-07
date_created: 2018-12-11T12:01:35Z
date_published: 2012-07-01T00:00:00Z
date_updated: 2021-01-12T07:41:18Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-642-31424-7_8
ec_funded: 1
intvolume: ' 7358'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1202.0796
month: '07'
oa: 1
oa_version: Preprint
page: 23 - 38
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '3562'
quality_controlled: '1'
scopus_import: 1
status: public
title: Efficient controller synthesis for consumption games with multiple resource
types
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7358
year: '2012'
...
---
_id: '3133'
abstract:
- lang: eng
text: 'This note contributes to the point calculus of persistent homology by extending
Alexander duality from spaces to real-valued functions. Given a perfect Morse
function f: S n+1 →[0, 1 and a decomposition S n+1 = U ∪ V into two (n + 1)-manifolds
with common boundary M, we prove elementary relationships between the persistence
diagrams of f restricted to U, to V, and to M. '
acknowledgement: "his research is partially supported by the National Science Foundation
(NSF) under grant DBI-0820624, the European Science Foundation under the Research
Networking Programme, and the Russian Government Project 11.G34.31.0053.\r\nThe
authors thank an anonymous referee for suggesting the simplified proof of the Contravariant
PE Theorem given in this paper. They also thank Frederick Cohen, Yuriy Mileyko and
Amit Patel for helpful discussions."
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Kerber, Michael
id: 36E4574A-F248-11E8-B48F-1D18A9856A87
last_name: Kerber
orcid: 0000-0002-8030-9299
citation:
ama: 'Edelsbrunner H, Kerber M. Alexander duality for functions: The persistent
behavior of land and water and shore. In: Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry . ACM; 2012:249-258. doi:10.1145/2261250.2261287'
apa: 'Edelsbrunner, H., & Kerber, M. (2012). Alexander duality for functions:
The persistent behavior of land and water and shore. In Proceedings of the
twenty-eighth annual symposium on Computational geometry (pp. 249–258). Chapel
Hill, NC, USA: ACM. https://doi.org/10.1145/2261250.2261287'
chicago: 'Edelsbrunner, Herbert, and Michael Kerber. “Alexander Duality for Functions:
The Persistent Behavior of Land and Water and Shore.” In Proceedings of the
Twenty-Eighth Annual Symposium on Computational Geometry , 249–58. ACM, 2012.
https://doi.org/10.1145/2261250.2261287.'
ieee: 'H. Edelsbrunner and M. Kerber, “Alexander duality for functions: The persistent
behavior of land and water and shore,” in Proceedings of the twenty-eighth
annual symposium on Computational geometry , Chapel Hill, NC, USA, 2012, pp.
249–258.'
ista: 'Edelsbrunner H, Kerber M. 2012. Alexander duality for functions: The persistent
behavior of land and water and shore. Proceedings of the twenty-eighth annual
symposium on Computational geometry . SCG: Symposium on Computational Geometry,
249–258.'
mla: 'Edelsbrunner, Herbert, and Michael Kerber. “Alexander Duality for Functions:
The Persistent Behavior of Land and Water and Shore.” Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 249–58, doi:10.1145/2261250.2261287.'
short: H. Edelsbrunner, M. Kerber, in:, Proceedings of the Twenty-Eighth Annual
Symposium on Computational Geometry , ACM, 2012, pp. 249–258.
conference:
end_date: 2012-06-20
location: Chapel Hill, NC, USA
name: 'SCG: Symposium on Computational Geometry'
start_date: 2012-06-17
date_created: 2018-12-11T12:01:35Z
date_published: 2012-06-20T00:00:00Z
date_updated: 2021-01-12T07:41:17Z
day: '20'
department:
- _id: HeEd
doi: 10.1145/2261250.2261287
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1109.5052
month: '06'
oa: 1
oa_version: Preprint
page: 249 - 258
publication: 'Proceedings of the twenty-eighth annual symposium on Computational geometry '
publication_status: published
publisher: ACM
publist_id: '3564'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Alexander duality for functions: The persistent behavior of land and water
and shore'
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2012'
...
---
_id: '3134'
abstract:
- lang: eng
text: 'It has been an open question whether the sum of finitely many isotropic Gaussian
kernels in n ≥ 2 dimensions can have more modes than kernels, until in 2003 Carreira-Perpiñán
and Williams exhibited n +1 isotropic Gaussian kernels in ℝ n with n + 2 modes.
We give a detailed analysis of this example, showing that it has exponentially
many critical points and that the resilience of the extra mode grows like √n.
In addition, we exhibit finite configurations of isotropic Gaussian kernels with
superlinearly many modes. '
acknowledgement: This research is partially supported by the National Science Foun-
dation (NSF) under grant DBI-0820624, by the European Science Foundation under the
Research Networking Programme, and the Russian Government Project 11.G34.31.0053.
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Brittany
full_name: Fasy, Brittany
last_name: Fasy
- first_name: Günter
full_name: Rote, Günter
last_name: Rote
citation:
ama: 'Edelsbrunner H, Fasy B, Rote G. Add isotropic Gaussian kernels at own risk:
More and more resilient modes in higher dimensions. In: Proceedings of the
Twenty-Eighth Annual Symposium on Computational Geometry . ACM; 2012:91-100.
doi:10.1145/2261250.2261265'
apa: 'Edelsbrunner, H., Fasy, B., & Rote, G. (2012). Add isotropic Gaussian
kernels at own risk: More and more resilient modes in higher dimensions. In Proceedings
of the twenty-eighth annual symposium on Computational geometry (pp. 91–100).
Chapel Hill, NC, USA: ACM. https://doi.org/10.1145/2261250.2261265'
chicago: 'Edelsbrunner, Herbert, Brittany Fasy, and Günter Rote. “Add Isotropic
Gaussian Kernels at Own Risk: More and More Resilient Modes in Higher Dimensions.”
In Proceedings of the Twenty-Eighth Annual Symposium on Computational Geometry
, 91–100. ACM, 2012. https://doi.org/10.1145/2261250.2261265.'
ieee: 'H. Edelsbrunner, B. Fasy, and G. Rote, “Add isotropic Gaussian kernels at
own risk: More and more resilient modes in higher dimensions,” in Proceedings
of the twenty-eighth annual symposium on Computational geometry , Chapel Hill,
NC, USA, 2012, pp. 91–100.'
ista: 'Edelsbrunner H, Fasy B, Rote G. 2012. Add isotropic Gaussian kernels at own
risk: More and more resilient modes in higher dimensions. Proceedings of the twenty-eighth
annual symposium on Computational geometry . SCG: Symposium on Computational Geometry,
91–100.'
mla: 'Edelsbrunner, Herbert, et al. “Add Isotropic Gaussian Kernels at Own Risk:
More and More Resilient Modes in Higher Dimensions.” Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 91–100, doi:10.1145/2261250.2261265.'
short: H. Edelsbrunner, B. Fasy, G. Rote, in:, Proceedings of the Twenty-Eighth
Annual Symposium on Computational Geometry , ACM, 2012, pp. 91–100.
conference:
end_date: 2012-06-20
location: Chapel Hill, NC, USA
name: 'SCG: Symposium on Computational Geometry'
start_date: 2012-06-17
date_created: 2018-12-11T12:01:35Z
date_published: 2012-06-20T00:00:00Z
date_updated: 2023-02-23T10:59:27Z
day: '20'
department:
- _id: HeEd
doi: 10.1145/2261250.2261265
language:
- iso: eng
month: '06'
oa_version: None
page: 91 - 100
publication: 'Proceedings of the twenty-eighth annual symposium on Computational geometry '
publication_status: published
publisher: ACM
publist_id: '3563'
quality_controlled: '1'
related_material:
record:
- id: '2815'
relation: later_version
status: public
scopus_import: 1
status: public
title: 'Add isotropic Gaussian kernels at own risk: More and more resilient modes
in higher dimensions'
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2012'
...