@article{8074, abstract = {Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interaction of excitatory and inhibitory receptive field plasticity. The introduction of inhibitory plasticity in suitable recurrent networks provides a homeostatic mechanism that leads to asynchronous irregular network states. Further, it can accommodate synaptic memories with activity patterns that become indiscernible from the background state but can be reactivated by external stimuli. Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry.}, author = {Vogels, Tim P and Sprekeler, H. and Zenke, F. and Clopath, C. and Gerstner, W.}, issn = {0036-8075}, journal = {Science}, number = {6062}, pages = {1569--1573}, publisher = {American Association for the Advancement of Science}, title = {{Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks}}, doi = {10.1126/science.1211095}, volume = {334}, year = {2011}, } @article{8469, abstract = {The accurate experimental determination of dipolar-coupling constants for one-bond heteronuclear dipolar couplings in solids is a key for the quantification of the amplitudes of motional processes. Averaging of the dipolar coupling reports on motions on time scales up to the inverse of the coupling constant, in our case tens of microseconds. Combining dipolar-coupling derived order parameters that characterize the amplitudes of the motion with relaxation data leads to a more precise characterization of the dynamical parameters and helps to disentangle the amplitudes and the time scales of the motional processes, which impact relaxation rates in a highly correlated way. Here. we describe and characterize an improved experimental protocol – based on REDOR – to measure these couplings in perdeuterated proteins with a reduced sensitivity to experimental missettings. Because such effects are presently the dominant source of systematic errors in experimental dipolar-coupling measurements, these compensated experiments should help to significantly improve the precision of such data. A detailed comparison with other commonly used pulse sequences (T-MREV, phase-inverted CP,R18 5/2, and R18 7/1) is provided.}, author = {Schanda, Paul and Meier, Beat H. and Ernst, Matthias}, issn = {1090-7807}, journal = {Journal of Magnetic Resonance}, keywords = {Nuclear and High Energy Physics, Biophysics, Biochemistry, Condensed Matter Physics}, number = {2}, pages = {246--259}, publisher = {Elsevier}, title = {{Accurate measurement of one-bond H–X heteronuclear dipolar couplings in MAS solid-state NMR}}, doi = {10.1016/j.jmr.2011.03.015}, volume = {210}, year = {2011}, } @article{8470, abstract = {Adding a new dimension: 4D or 3D proton‐detected spectra of perdeuterated protein samples with 1H labelled amides and methyl groups permit collecting unambiguous distance restraints with high sensitivity and determining protein structure by solid‐state NMR (see picture).}, author = {Huber, Matthias and Hiller, Sebastian and Schanda, Paul and Ernst, Matthias and Böckmann, Anja and Verel, René and Meier, Beat H.}, issn = {1439-4235}, journal = {ChemPhysChem}, keywords = {Physical and Theoretical Chemistry, Atomic and Molecular Physics, and Optics}, number = {5}, pages = {915--918}, publisher = {Wiley}, title = {{A proton-detected 4D solid-state NMR experiment for protein structure determination}}, doi = {10.1002/cphc.201100062}, volume = {12}, year = {2011}, } @article{8464, abstract = {Nonsymmetric motion: Solid‐state NMR measurements of dipolar coupling tensors provide insight into protein dynamics. The hitherto ignored asymmetry of the dipolar coupling tensor contains valuable information about motional asymmetry, which was used in the first direct site‐resolved measurement of such tensors. Important motions such as rotamer jumps can now be directly detected in the solid state.}, author = {Schanda, Paul and Huber, Matthias and Boisbouvier, Jérôme and Meier, Beat H. and Ernst, Matthias}, issn = {1433-7851}, journal = {Angewandte Chemie International Edition}, number = {46}, pages = {11005--11009}, publisher = {Wiley}, title = {{Solid-state NMR measurements of asymmetric dipolar couplings provide insight into protein side-chain motion}}, doi = {10.1002/anie.201103944}, volume = {50}, year = {2011}, } @article{8468, author = {Lalli, Daniela and Schanda, Paul and Chowdhury, Anup and Retel, Joren and Hiller, Matthias and Higman, Victoria A. and Handel, Lieselotte and Agarwal, Vipin and Reif, Bernd and van Rossum, Barth and Akbey, Ümit and Oschkinat, Hartmut}, issn = {0925-2738}, journal = {Journal of Biomolecular NMR}, number = {4}, pages = {477--485}, publisher = {Springer Nature}, title = {{Three-dimensional deuterium-carbon correlation experiments for high-resolution solid-state MAS NMR spectroscopy of large proteins}}, doi = {10.1007/s10858-011-9578-1}, volume = {51}, year = {2011}, }