--- _id: '3814' abstract: - lang: eng text: The axon terminals (mossy fibers) of hippocampal dentate granule cells form characteristic synaptic connections with large spines or excrescences of both hilar mossy cells and CA3 pyramidal neurons. Interneurons of the hilar region and area CA3 are also prominent targets of mossy fibers. The tracing of biocytin-filled mossy fibers and immunolabeling of target cells with interneuron markers has revealed that the majority of mossy fiber synapses project to gamma aminobutyric acid (GABA)-ergic inhibitory interneurons rather than to excitatory principal cells, although the functional implications of these quantitative differences are unclear. Following a brief description of the "classical" mossy fiber synapse on excrescences of CA3 pyramidal cells, the present review focuses on the contacts formed between granule cells and GABAergic interneurons, both normally and after synaptic reorganization. In response to deafferentation of mossy cell target cells, which include both granule cells and interneurons, mossy fibers "sprout" new axon collaterals that form a band of supragranular mossy fibers in the inner molecular layer of the dentate gyrus. Although most newly formed recurrent mossy fibers establish synapses with granule cells, there is an apparently convergent input of new mossy fibers onto GABA-immunoreactive interneuron dendrites that traverse the inner molecular layer. These mossy fiber-interneuron synapses in the dentate gyrus are observed in chronically epileptic rats and may be the structural correlate of the granule cell hyperinhibition observed in these animals in vivo. Together, the findings reviewed here establish mossy fiber synapses as an important component of inhibitory circuits in the hippocampus. author: - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Robert full_name: Sloviter, Robert S last_name: Sloviter citation: ama: Frotscher M, Jonas PM, Sloviter R. Synapses formed by normal and abnormal hippocampal mossy fibers (Review). Cell and Tissue Research. 2006;326(2):361-367. doi:10.1007/s00441-006-0269-2 apa: Frotscher, M., Jonas, P. M., & Sloviter, R. (2006). Synapses formed by normal and abnormal hippocampal mossy fibers (Review). Cell and Tissue Research. Springer. https://doi.org/10.1007/s00441-006-0269-2 chicago: Frotscher, Michael, Peter M Jonas, and Robert Sloviter. “Synapses Formed by Normal and Abnormal Hippocampal Mossy Fibers (Review).” Cell and Tissue Research. Springer, 2006. https://doi.org/10.1007/s00441-006-0269-2. ieee: M. Frotscher, P. M. Jonas, and R. Sloviter, “Synapses formed by normal and abnormal hippocampal mossy fibers (Review),” Cell and Tissue Research, vol. 326, no. 2. Springer, pp. 361–7, 2006. ista: Frotscher M, Jonas PM, Sloviter R. 2006. Synapses formed by normal and abnormal hippocampal mossy fibers (Review). Cell and Tissue Research. 326(2), 361–7. mla: Frotscher, Michael, et al. “Synapses Formed by Normal and Abnormal Hippocampal Mossy Fibers (Review).” Cell and Tissue Research, vol. 326, no. 2, Springer, 2006, pp. 361–67, doi:10.1007/s00441-006-0269-2. short: M. Frotscher, P.M. Jonas, R. Sloviter, Cell and Tissue Research 326 (2006) 361–7. date_created: 2018-12-11T12:05:19Z date_published: 2006-01-01T00:00:00Z date_updated: 2019-04-26T07:22:35Z day: '01' doi: 10.1007/s00441-006-0269-2 extern: 1 intvolume: ' 326' issue: '2' month: '01' page: 361 - 7 publication: Cell and Tissue Research publication_status: published publisher: Springer publist_id: '2395' quality_controlled: 0 status: public title: Synapses formed by normal and abnormal hippocampal mossy fibers (Review) type: review volume: 326 year: '2006' ... --- _id: '3815' abstract: - lang: eng text: It is widely accepted that the hippocampus plays a major role in learning and memory. The mossy fiber synapse between granule cells in the dentate gyrus and pyramidal neurons in the CA3 region is a key component of the hippocampal trisynaptic circuit. Recent work, partially based on direct presynaptic patch-clamp recordings from hippocampal mossy fiber boutons, sheds light on the mechanisms of synaptic transmission and plasticity at mossy fiber synapses. A high Na(+) channel density in mossy fiber boutons leads to a large amplitude of the presynaptic action potential. Together with the fast gating of presynaptic Ca(2+) channels, this generates a large and brief presynaptic Ca(2+) influx, which can trigger transmitter release with high efficiency and temporal precision. The large number of release sites, the large size of the releasable pool of vesicles, and the huge extent of presynaptic plasticity confer unique strength to this synapse, suggesting a large impact onto the CA3 pyramidal cell network under specific behavioral conditions. The characteristic properties of the hippocampal mossy fiber synapse may be important for pattern separation and information storage in the dentate gyrus-CA3 cell network. author: - first_name: Josef full_name: Bischofberger, Josef last_name: Bischofberger - first_name: Dominique full_name: Engel, Dominique last_name: Engel - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: 'Bischofberger J, Engel D, Frotscher M, Jonas PM. Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network. Pflugers Archiv : European Journal of Physiology. 2006;453(3):361-372. doi:10.1007/s00424-006-0093-2' apa: 'Bischofberger, J., Engel, D., Frotscher, M., & Jonas, P. M. (2006). Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network. Pflugers Archiv : European Journal of Physiology. Springer. https://doi.org/10.1007/s00424-006-0093-2' chicago: 'Bischofberger, Josef, Dominique Engel, Michael Frotscher, and Peter M Jonas. “Timing and Efficacy of Transmitter Release at Mossy Fiber Synapses in the Hippocampal Network.” Pflugers Archiv : European Journal of Physiology. Springer, 2006. https://doi.org/10.1007/s00424-006-0093-2.' ieee: 'J. Bischofberger, D. Engel, M. Frotscher, and P. M. Jonas, “Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network,” Pflugers Archiv : European Journal of Physiology, vol. 453, no. 3. Springer, pp. 361–72, 2006.' ista: 'Bischofberger J, Engel D, Frotscher M, Jonas PM. 2006. Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network. Pflugers Archiv : European Journal of Physiology. 453(3), 361–72.' mla: 'Bischofberger, Josef, et al. “Timing and Efficacy of Transmitter Release at Mossy Fiber Synapses in the Hippocampal Network.” Pflugers Archiv : European Journal of Physiology, vol. 453, no. 3, Springer, 2006, pp. 361–72, doi:10.1007/s00424-006-0093-2.' short: 'J. Bischofberger, D. Engel, M. Frotscher, P.M. Jonas, Pflugers Archiv : European Journal of Physiology 453 (2006) 361–72.' date_created: 2018-12-11T12:05:19Z date_published: 2006-01-01T00:00:00Z date_updated: 2021-01-12T07:52:24Z day: '01' doi: 10.1007/s00424-006-0093-2 extern: 1 intvolume: ' 453' issue: '3' month: '01' page: 361 - 72 publication: 'Pflugers Archiv : European Journal of Physiology' publication_status: published publisher: Springer publist_id: '2396' quality_controlled: 0 status: public title: Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network type: journal_article volume: 453 year: '2006' ... --- _id: '3811' abstract: - lang: eng text: Networks of GABAergic neurons are key elements in the generation of gamma oscillations in the brain. Computational studies suggested that the emergence of coherent oscillations requires hyperpolarizing inhibition. Here, we show that GABA(A) receptor-mediated inhibition in mature interneurons of the hippocampal dentate gyrus is shunting rather than hyperpolarizing. Unexpectedly, when shunting inhibition is incorporated into a structured interneuron network model with fast and strong synapses, coherent oscillations emerge. In comparison to hyperpolarizing inhibition, networks with shunting inhibition show several advantages. First, oscillations are generated with smaller tonic excitatory drive. Second, network frequencies are tuned to the gamma band. Finally, robustness against heterogeneity in the excitatory drive is markedly improved. In single interneurons, shunting inhibition shortens the interspike interval for low levels of drive but prolongs it for high levels, leading to homogenization of neuronal firing rates. Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain. author: - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Marlene full_name: Bartos, Marlene last_name: Bartos - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Vida I, Bartos M, Jonas PM. Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates. Neuron. 2006;49(1):107-117. doi:10.1016/j.neuron.2005.11.036 apa: Vida, I., Bartos, M., & Jonas, P. M. (2006). Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.11.036 chicago: Vida, Imre, Marlene Bartos, and Peter M Jonas. “Shunting Inhibition Improves Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing Firing Rates.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.11.036. ieee: I. Vida, M. Bartos, and P. M. Jonas, “Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates,” Neuron, vol. 49, no. 1. Elsevier, pp. 107–17, 2006. ista: Vida I, Bartos M, Jonas PM. 2006. Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates. Neuron. 49(1), 107–17. mla: Vida, Imre, et al. “Shunting Inhibition Improves Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing Firing Rates.” Neuron, vol. 49, no. 1, Elsevier, 2006, pp. 107–17, doi:10.1016/j.neuron.2005.11.036. short: I. Vida, M. Bartos, P.M. Jonas, Neuron 49 (2006) 107–17. date_created: 2018-12-11T12:05:18Z date_published: 2006-01-01T00:00:00Z date_updated: 2021-01-12T07:52:22Z day: '01' doi: 10.1016/j.neuron.2005.11.036 extern: 1 intvolume: ' 49' issue: '1' month: '01' page: 107 - 17 publication: Neuron publication_status: published publisher: Elsevier publist_id: '2398' quality_controlled: 0 status: public title: Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates type: journal_article volume: 49 year: '2006' ... --- _id: '3817' author: - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Eckart full_name: Gundelfinger, Eckart last_name: Gundelfinger - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Erwin full_name: Neher, Erwin last_name: Neher - first_name: Peter full_name: Seeburg, Peter last_name: Seeburg citation: ama: Frotscher M, Gundelfinger E, Jonas PM, Neher E, Seeburg P. The most important recent advances in synapse research from my point of view--and what remains to be done. Cell and Tissue Research. 2006;326(2):203-204. doi:10.1007/s00441-006-0325-y apa: Frotscher, M., Gundelfinger, E., Jonas, P. M., Neher, E., & Seeburg, P. (2006). The most important recent advances in synapse research from my point of view--and what remains to be done. Cell and Tissue Research. Springer. https://doi.org/10.1007/s00441-006-0325-y chicago: Frotscher, Michael, Eckart Gundelfinger, Peter M Jonas, Erwin Neher, and Peter Seeburg. “The Most Important Recent Advances in Synapse Research from My Point of View--and What Remains to Be Done.” Cell and Tissue Research. Springer, 2006. https://doi.org/10.1007/s00441-006-0325-y. ieee: M. Frotscher, E. Gundelfinger, P. M. Jonas, E. Neher, and P. Seeburg, “The most important recent advances in synapse research from my point of view--and what remains to be done,” Cell and Tissue Research, vol. 326, no. 2. Springer, pp. 203–4, 2006. ista: Frotscher M, Gundelfinger E, Jonas PM, Neher E, Seeburg P. 2006. The most important recent advances in synapse research from my point of view--and what remains to be done. Cell and Tissue Research. 326(2), 203–4. mla: Frotscher, Michael, et al. “The Most Important Recent Advances in Synapse Research from My Point of View--and What Remains to Be Done.” Cell and Tissue Research, vol. 326, no. 2, Springer, 2006, pp. 203–04, doi:10.1007/s00441-006-0325-y. short: M. Frotscher, E. Gundelfinger, P.M. Jonas, E. Neher, P. Seeburg, Cell and Tissue Research 326 (2006) 203–4. date_created: 2018-12-11T12:05:20Z date_published: 2006-01-01T00:00:00Z date_updated: 2021-01-12T07:52:24Z day: '01' doi: 10.1007/s00441-006-0325-y extern: 1 intvolume: ' 326' issue: '2' month: '01' page: 203 - 4 publication: Cell and Tissue Research publication_status: published publisher: Springer publist_id: '2394' quality_controlled: 0 status: public title: The most important recent advances in synapse research from my point of view--and what remains to be done type: journal_article volume: 326 year: '2006' ... --- _id: '3912' abstract: - lang: eng text: Invasive species often dramatically change native species communities by directly and indirectly out-competing native species. We studied the direct interference abilities of the invasive garden ant, Lasius neglectus VAN LOON, BOOMSMA & ANDRÁSFALVY, 1990, by performing one-to-one aggression tests of L. neglectus workers towards three native Lasius ant species that occur at the edge of a L. neglectus supercolony in Seva, Spain. Our results show that L. neglectus is highly aggressive against all three native Lasius species tested (L. grandis FOREL, 1909, L. emarginatus (OLIVIER, 1792), and L. cinereus SEIFERT, 1992), expressed as a higher attack rate of L. neglectus and behavioural dominance throughout the aggressive encounters. Attacks of L. neglectus were performed fastest and most frequent against L. grandis, and also the highest antennation frequencies were observed in encounters between these two species. This could be due to the largest difference in body size, or due to a greater overlap in ecological niche between L. neglectus and L. grandis compared to the other two native species. There was only weak support for L. neglectus workers from the periphery of the supercolony to be more aggressive relative to workers from the centre, even though the former encounter native ant species on a daily basis at the edge of the supercolony. author: - first_name: Sylvia full_name: Cremer, Sylvia id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87 last_name: Cremer orcid: 0000-0002-2193-3868 - first_name: Line V full_name: Ugelvig, Line V id: 3DC97C8E-F248-11E8-B48F-1D18A9856A87 last_name: Ugelvig orcid: 0000-0003-1832-8883 - first_name: Suzanne full_name: Lommen, Suzanne last_name: Lommen - first_name: Klaus full_name: Petersen, Klaus last_name: Petersen - first_name: Jes full_name: Pedersen, Jes last_name: Pedersen citation: ama: 'Cremer S, Ugelvig LV, Lommen S, Petersen K, Pedersen J. Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae) against native Lasius species in Spain. Myrmecological News. 2006;9:13-19.' apa: 'Cremer, S., Ugelvig, L. V., Lommen, S., Petersen, K., & Pedersen, J. (2006). Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae) against native Lasius species in Spain. Myrmecological News. Österreichische Gesellschaft für Entomofaunistik.' chicago: 'Cremer, Sylvia, Line V Ugelvig, Suzanne Lommen, Klaus Petersen, and Jes Pedersen. “Attack of the Invasive Garden Ant: Aggression Behaviour of Lasius Neglectus (Hymenoptera: Formicidae) against Native Lasius Species in Spain.” Myrmecological News. Österreichische Gesellschaft für Entomofaunistik, 2006.' ieee: 'S. Cremer, L. V. Ugelvig, S. Lommen, K. Petersen, and J. Pedersen, “Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae) against native Lasius species in Spain,” Myrmecological News, vol. 9. Österreichische Gesellschaft für Entomofaunistik, pp. 13–19, 2006.' ista: 'Cremer S, Ugelvig LV, Lommen S, Petersen K, Pedersen J. 2006. Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae) against native Lasius species in Spain. Myrmecological News. 9, 13–19.' mla: 'Cremer, Sylvia, et al. “Attack of the Invasive Garden Ant: Aggression Behaviour of Lasius Neglectus (Hymenoptera: Formicidae) against Native Lasius Species in Spain.” Myrmecological News, vol. 9, Österreichische Gesellschaft für Entomofaunistik, 2006, pp. 13–19.' short: S. Cremer, L.V. Ugelvig, S. Lommen, K. Petersen, J. Pedersen, Myrmecological News 9 (2006) 13–19. date_created: 2018-12-11T12:05:51Z date_published: 2006-12-01T00:00:00Z date_updated: 2021-01-12T07:53:09Z day: '01' extern: '1' intvolume: ' 9' language: - iso: eng month: '12' oa_version: None page: 13 - 19 publication: Myrmecological News publication_status: published publisher: Österreichische Gesellschaft für Entomofaunistik publist_id: '2239' status: public title: 'Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae) against native Lasius species in Spain' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 9 year: '2006' ...