---
_id: '3814'
abstract:
- lang: eng
text: The axon terminals (mossy fibers) of hippocampal dentate granule cells form
characteristic synaptic connections with large spines or excrescences of both
hilar mossy cells and CA3 pyramidal neurons. Interneurons of the hilar region
and area CA3 are also prominent targets of mossy fibers. The tracing of biocytin-filled
mossy fibers and immunolabeling of target cells with interneuron markers has revealed
that the majority of mossy fiber synapses project to gamma aminobutyric acid (GABA)-ergic
inhibitory interneurons rather than to excitatory principal cells, although the
functional implications of these quantitative differences are unclear. Following
a brief description of the "classical" mossy fiber synapse on excrescences
of CA3 pyramidal cells, the present review focuses on the contacts formed between
granule cells and GABAergic interneurons, both normally and after synaptic reorganization.
In response to deafferentation of mossy cell target cells, which include both
granule cells and interneurons, mossy fibers "sprout" new axon collaterals
that form a band of supragranular mossy fibers in the inner molecular layer of
the dentate gyrus. Although most newly formed recurrent mossy fibers establish
synapses with granule cells, there is an apparently convergent input of new mossy
fibers onto GABA-immunoreactive interneuron dendrites that traverse the inner
molecular layer. These mossy fiber-interneuron synapses in the dentate gyrus are
observed in chronically epileptic rats and may be the structural correlate of
the granule cell hyperinhibition observed in these animals in vivo. Together,
the findings reviewed here establish mossy fiber synapses as an important component
of inhibitory circuits in the hippocampus.
author:
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Robert
full_name: Sloviter, Robert S
last_name: Sloviter
citation:
ama: Frotscher M, Jonas PM, Sloviter R. Synapses formed by normal and abnormal hippocampal
mossy fibers (Review). Cell and Tissue Research. 2006;326(2):361-367. doi:10.1007/s00441-006-0269-2
apa: Frotscher, M., Jonas, P. M., & Sloviter, R. (2006). Synapses formed by
normal and abnormal hippocampal mossy fibers (Review). Cell and Tissue Research.
Springer. https://doi.org/10.1007/s00441-006-0269-2
chicago: Frotscher, Michael, Peter M Jonas, and Robert Sloviter. “Synapses Formed
by Normal and Abnormal Hippocampal Mossy Fibers (Review).” Cell and Tissue
Research. Springer, 2006. https://doi.org/10.1007/s00441-006-0269-2.
ieee: M. Frotscher, P. M. Jonas, and R. Sloviter, “Synapses formed by normal and
abnormal hippocampal mossy fibers (Review),” Cell and Tissue Research,
vol. 326, no. 2. Springer, pp. 361–7, 2006.
ista: Frotscher M, Jonas PM, Sloviter R. 2006. Synapses formed by normal and abnormal
hippocampal mossy fibers (Review). Cell and Tissue Research. 326(2), 361–7.
mla: Frotscher, Michael, et al. “Synapses Formed by Normal and Abnormal Hippocampal
Mossy Fibers (Review).” Cell and Tissue Research, vol. 326, no. 2, Springer,
2006, pp. 361–67, doi:10.1007/s00441-006-0269-2.
short: M. Frotscher, P.M. Jonas, R. Sloviter, Cell and Tissue Research 326 (2006)
361–7.
date_created: 2018-12-11T12:05:19Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2019-04-26T07:22:35Z
day: '01'
doi: 10.1007/s00441-006-0269-2
extern: 1
intvolume: ' 326'
issue: '2'
month: '01'
page: 361 - 7
publication: Cell and Tissue Research
publication_status: published
publisher: Springer
publist_id: '2395'
quality_controlled: 0
status: public
title: Synapses formed by normal and abnormal hippocampal mossy fibers (Review)
type: review
volume: 326
year: '2006'
...
---
_id: '3815'
abstract:
- lang: eng
text: It is widely accepted that the hippocampus plays a major role in learning
and memory. The mossy fiber synapse between granule cells in the dentate gyrus
and pyramidal neurons in the CA3 region is a key component of the hippocampal
trisynaptic circuit. Recent work, partially based on direct presynaptic patch-clamp
recordings from hippocampal mossy fiber boutons, sheds light on the mechanisms
of synaptic transmission and plasticity at mossy fiber synapses. A high Na(+)
channel density in mossy fiber boutons leads to a large amplitude of the presynaptic
action potential. Together with the fast gating of presynaptic Ca(2+) channels,
this generates a large and brief presynaptic Ca(2+) influx, which can trigger
transmitter release with high efficiency and temporal precision. The large number
of release sites, the large size of the releasable pool of vesicles, and the huge
extent of presynaptic plasticity confer unique strength to this synapse, suggesting
a large impact onto the CA3 pyramidal cell network under specific behavioral conditions.
The characteristic properties of the hippocampal mossy fiber synapse may be important
for pattern separation and information storage in the dentate gyrus-CA3 cell network.
author:
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Dominique
full_name: Engel, Dominique
last_name: Engel
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Bischofberger J, Engel D, Frotscher M, Jonas PM. Timing and efficacy of transmitter
release at mossy fiber synapses in the hippocampal network. Pflugers Archiv :
European Journal of Physiology. 2006;453(3):361-372. doi:10.1007/s00424-006-0093-2'
apa: 'Bischofberger, J., Engel, D., Frotscher, M., & Jonas, P. M. (2006). Timing
and efficacy of transmitter release at mossy fiber synapses in the hippocampal
network. Pflugers Archiv : European Journal of Physiology. Springer. https://doi.org/10.1007/s00424-006-0093-2'
chicago: 'Bischofberger, Josef, Dominique Engel, Michael Frotscher, and Peter M
Jonas. “Timing and Efficacy of Transmitter Release at Mossy Fiber Synapses in
the Hippocampal Network.” Pflugers Archiv : European Journal of Physiology.
Springer, 2006. https://doi.org/10.1007/s00424-006-0093-2.'
ieee: 'J. Bischofberger, D. Engel, M. Frotscher, and P. M. Jonas, “Timing and efficacy
of transmitter release at mossy fiber synapses in the hippocampal network,” Pflugers
Archiv : European Journal of Physiology, vol. 453, no. 3. Springer, pp. 361–72,
2006.'
ista: 'Bischofberger J, Engel D, Frotscher M, Jonas PM. 2006. Timing and efficacy
of transmitter release at mossy fiber synapses in the hippocampal network. Pflugers
Archiv : European Journal of Physiology. 453(3), 361–72.'
mla: 'Bischofberger, Josef, et al. “Timing and Efficacy of Transmitter Release at
Mossy Fiber Synapses in the Hippocampal Network.” Pflugers Archiv : European
Journal of Physiology, vol. 453, no. 3, Springer, 2006, pp. 361–72, doi:10.1007/s00424-006-0093-2.'
short: 'J. Bischofberger, D. Engel, M. Frotscher, P.M. Jonas, Pflugers Archiv :
European Journal of Physiology 453 (2006) 361–72.'
date_created: 2018-12-11T12:05:19Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:24Z
day: '01'
doi: 10.1007/s00424-006-0093-2
extern: 1
intvolume: ' 453'
issue: '3'
month: '01'
page: 361 - 72
publication: 'Pflugers Archiv : European Journal of Physiology'
publication_status: published
publisher: Springer
publist_id: '2396'
quality_controlled: 0
status: public
title: Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal
network
type: journal_article
volume: 453
year: '2006'
...
---
_id: '3811'
abstract:
- lang: eng
text: Networks of GABAergic neurons are key elements in the generation of gamma
oscillations in the brain. Computational studies suggested that the emergence
of coherent oscillations requires hyperpolarizing inhibition. Here, we show that
GABA(A) receptor-mediated inhibition in mature interneurons of the hippocampal
dentate gyrus is shunting rather than hyperpolarizing. Unexpectedly, when shunting
inhibition is incorporated into a structured interneuron network model with fast
and strong synapses, coherent oscillations emerge. In comparison to hyperpolarizing
inhibition, networks with shunting inhibition show several advantages. First,
oscillations are generated with smaller tonic excitatory drive. Second, network
frequencies are tuned to the gamma band. Finally, robustness against heterogeneity
in the excitatory drive is markedly improved. In single interneurons, shunting
inhibition shortens the interspike interval for low levels of drive but prolongs
it for high levels, leading to homogenization of neuronal firing rates. Thus,
shunting inhibition may confer increased robustness to gamma oscillations in the
brain.
author:
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vida I, Bartos M, Jonas PM. Shunting inhibition improves robustness of gamma
oscillations in hippocampal interneuron networks by homogenizing firing rates.
Neuron. 2006;49(1):107-117. doi:10.1016/j.neuron.2005.11.036
apa: Vida, I., Bartos, M., & Jonas, P. M. (2006). Shunting inhibition improves
robustness of gamma oscillations in hippocampal interneuron networks by homogenizing
firing rates. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.11.036
chicago: Vida, Imre, Marlene Bartos, and Peter M Jonas. “Shunting Inhibition Improves
Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing
Firing Rates.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.11.036.
ieee: I. Vida, M. Bartos, and P. M. Jonas, “Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates,” Neuron, vol. 49, no. 1. Elsevier, pp. 107–17, 2006.
ista: Vida I, Bartos M, Jonas PM. 2006. Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates. Neuron. 49(1), 107–17.
mla: Vida, Imre, et al. “Shunting Inhibition Improves Robustness of Gamma Oscillations
in Hippocampal Interneuron Networks by Homogenizing Firing Rates.” Neuron,
vol. 49, no. 1, Elsevier, 2006, pp. 107–17, doi:10.1016/j.neuron.2005.11.036.
short: I. Vida, M. Bartos, P.M. Jonas, Neuron 49 (2006) 107–17.
date_created: 2018-12-11T12:05:18Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:22Z
day: '01'
doi: 10.1016/j.neuron.2005.11.036
extern: 1
intvolume: ' 49'
issue: '1'
month: '01'
page: 107 - 17
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2398'
quality_controlled: 0
status: public
title: Shunting inhibition improves robustness of gamma oscillations in hippocampal
interneuron networks by homogenizing firing rates
type: journal_article
volume: 49
year: '2006'
...
---
_id: '3817'
author:
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Eckart
full_name: Gundelfinger, Eckart
last_name: Gundelfinger
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Erwin
full_name: Neher, Erwin
last_name: Neher
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
citation:
ama: Frotscher M, Gundelfinger E, Jonas PM, Neher E, Seeburg P. The most important
recent advances in synapse research from my point of view--and what remains to
be done. Cell and Tissue Research. 2006;326(2):203-204. doi:10.1007/s00441-006-0325-y
apa: Frotscher, M., Gundelfinger, E., Jonas, P. M., Neher, E., & Seeburg, P.
(2006). The most important recent advances in synapse research from my point of
view--and what remains to be done. Cell and Tissue Research. Springer.
https://doi.org/10.1007/s00441-006-0325-y
chicago: Frotscher, Michael, Eckart Gundelfinger, Peter M Jonas, Erwin Neher, and
Peter Seeburg. “The Most Important Recent Advances in Synapse Research from My
Point of View--and What Remains to Be Done.” Cell and Tissue Research.
Springer, 2006. https://doi.org/10.1007/s00441-006-0325-y.
ieee: M. Frotscher, E. Gundelfinger, P. M. Jonas, E. Neher, and P. Seeburg, “The
most important recent advances in synapse research from my point of view--and
what remains to be done,” Cell and Tissue Research, vol. 326, no. 2. Springer,
pp. 203–4, 2006.
ista: Frotscher M, Gundelfinger E, Jonas PM, Neher E, Seeburg P. 2006. The most
important recent advances in synapse research from my point of view--and what
remains to be done. Cell and Tissue Research. 326(2), 203–4.
mla: Frotscher, Michael, et al. “The Most Important Recent Advances in Synapse Research
from My Point of View--and What Remains to Be Done.” Cell and Tissue Research,
vol. 326, no. 2, Springer, 2006, pp. 203–04, doi:10.1007/s00441-006-0325-y.
short: M. Frotscher, E. Gundelfinger, P.M. Jonas, E. Neher, P. Seeburg, Cell and
Tissue Research 326 (2006) 203–4.
date_created: 2018-12-11T12:05:20Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:24Z
day: '01'
doi: 10.1007/s00441-006-0325-y
extern: 1
intvolume: ' 326'
issue: '2'
month: '01'
page: 203 - 4
publication: Cell and Tissue Research
publication_status: published
publisher: Springer
publist_id: '2394'
quality_controlled: 0
status: public
title: The most important recent advances in synapse research from my point of view--and
what remains to be done
type: journal_article
volume: 326
year: '2006'
...
---
_id: '3912'
abstract:
- lang: eng
text: Invasive species often dramatically change native species communities by directly
and indirectly out-competing native species. We studied the direct interference
abilities of the invasive garden ant, Lasius neglectus VAN LOON, BOOMSMA &
ANDRÁSFALVY, 1990, by performing one-to-one aggression tests of L. neglectus workers
towards three native Lasius ant species that occur at the edge of a L. neglectus
supercolony in Seva, Spain. Our results show that L. neglectus is highly aggressive
against all three native Lasius species tested (L. grandis FOREL, 1909, L. emarginatus
(OLIVIER, 1792), and L. cinereus SEIFERT, 1992), expressed as a higher attack
rate of L. neglectus and behavioural dominance throughout the aggressive encounters.
Attacks of L. neglectus were performed fastest and most frequent against L. grandis,
and also the highest antennation frequencies were observed in encounters between
these two species. This could be due to the largest difference in body size, or
due to a greater overlap in ecological niche between L. neglectus and L. grandis
compared to the other two native species. There was only weak support for L. neglectus
workers from the periphery of the supercolony to be more aggressive relative to
workers from the centre, even though the former encounter native ant species on
a daily basis at the edge of the supercolony.
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Line V
full_name: Ugelvig, Line V
id: 3DC97C8E-F248-11E8-B48F-1D18A9856A87
last_name: Ugelvig
orcid: 0000-0003-1832-8883
- first_name: Suzanne
full_name: Lommen, Suzanne
last_name: Lommen
- first_name: Klaus
full_name: Petersen, Klaus
last_name: Petersen
- first_name: Jes
full_name: Pedersen, Jes
last_name: Pedersen
citation:
ama: 'Cremer S, Ugelvig LV, Lommen S, Petersen K, Pedersen J. Attack of the invasive
garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae)
against native Lasius species in Spain. Myrmecological News. 2006;9:13-19.'
apa: 'Cremer, S., Ugelvig, L. V., Lommen, S., Petersen, K., & Pedersen, J. (2006).
Attack of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera:
Formicidae) against native Lasius species in Spain. Myrmecological News.
Österreichische Gesellschaft für Entomofaunistik.'
chicago: 'Cremer, Sylvia, Line V Ugelvig, Suzanne Lommen, Klaus Petersen, and Jes
Pedersen. “Attack of the Invasive Garden Ant: Aggression Behaviour of Lasius Neglectus
(Hymenoptera: Formicidae) against Native Lasius Species in Spain.” Myrmecological
News. Österreichische Gesellschaft für Entomofaunistik, 2006.'
ieee: 'S. Cremer, L. V. Ugelvig, S. Lommen, K. Petersen, and J. Pedersen, “Attack
of the invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera:
Formicidae) against native Lasius species in Spain,” Myrmecological News,
vol. 9. Österreichische Gesellschaft für Entomofaunistik, pp. 13–19, 2006.'
ista: 'Cremer S, Ugelvig LV, Lommen S, Petersen K, Pedersen J. 2006. Attack of the
invasive garden ant: aggression behaviour of Lasius neglectus (Hymenoptera: Formicidae)
against native Lasius species in Spain. Myrmecological News. 9, 13–19.'
mla: 'Cremer, Sylvia, et al. “Attack of the Invasive Garden Ant: Aggression Behaviour
of Lasius Neglectus (Hymenoptera: Formicidae) against Native Lasius Species in
Spain.” Myrmecological News, vol. 9, Österreichische Gesellschaft für Entomofaunistik,
2006, pp. 13–19.'
short: S. Cremer, L.V. Ugelvig, S. Lommen, K. Petersen, J. Pedersen, Myrmecological
News 9 (2006) 13–19.
date_created: 2018-12-11T12:05:51Z
date_published: 2006-12-01T00:00:00Z
date_updated: 2021-01-12T07:53:09Z
day: '01'
extern: '1'
intvolume: ' 9'
language:
- iso: eng
month: '12'
oa_version: None
page: 13 - 19
publication: Myrmecological News
publication_status: published
publisher: Österreichische Gesellschaft für Entomofaunistik
publist_id: '2239'
status: public
title: 'Attack of the invasive garden ant: aggression behaviour of Lasius neglectus
(Hymenoptera: Formicidae) against native Lasius species in Spain'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2006'
...