[{"status":"public","type":"book_chapter","_id":"2464","editor":[{"first_name":"Andrew","last_name":"Fleming","full_name":"Fleming, Andrew J."}],"title":"Auxin as an intercellular signal","author":[{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596"},{"first_name":"Justyna","last_name":"Wiśniewska","full_name":"Wiśniewska, Justyna"}],"publist_id":"4439","extern":1,"date_updated":"2021-01-12T06:57:38Z","citation":{"apa":"Friml, J., & Wiśniewska, J. (2005). Auxin as an intercellular signal. In A. Fleming (Ed.), Intercellular Communication in Plants (Vol. 16). Wiley-Blackwell.","ama":"Friml J, Wiśniewska J. Auxin as an intercellular signal. In: Fleming A, ed. Intercellular Communication in Plants. Vol 16. Wiley-Blackwell; 2005.","short":"J. Friml, J. Wiśniewska, in:, A. Fleming (Ed.), Intercellular Communication in Plants, Wiley-Blackwell, 2005.","ieee":"J. Friml and J. Wiśniewska, “Auxin as an intercellular signal,” in Intercellular Communication in Plants, vol. 16, A. Fleming, Ed. Wiley-Blackwell, 2005.","mla":"Friml, Jiří, and Justyna Wiśniewska. “Auxin as an Intercellular Signal.” Intercellular Communication in Plants, edited by Andrew Fleming, vol. 16, Wiley-Blackwell, 2005.","ista":"Friml J, Wiśniewska J. 2005.Auxin as an intercellular signal. In: Intercellular Communication in Plants. Annual Plant Reviews, vol. 16.","chicago":"Friml, Jiří, and Justyna Wiśniewska. “Auxin as an Intercellular Signal.” In Intercellular Communication in Plants, edited by Andrew Fleming, Vol. 16. Wiley-Blackwell, 2005."},"month":"01","intvolume":" 16","quality_controlled":0,"publisher":"Wiley-Blackwell","alternative_title":["Annual Plant Reviews"],"date_published":"2005-01-13T00:00:00Z","volume":16,"date_created":"2018-12-11T11:57:49Z","day":"13","publication":"Intercellular Communication in Plants","publication_status":"published","year":"2005"},{"month":"10","intvolume":" 12","publisher":"Wiley-Blackwell","quality_controlled":0,"volume":12,"date_published":"2005-10-28T00:00:00Z","doi":"10.1002/3527600906","date_created":"2018-12-11T11:57:48Z","page":"249 - 295","day":"28","publication":"Encyclopedia of Molecular Cell Biology and Molecular Medicine","year":"2005","publication_status":"published","status":"public","type":"book_chapter","_id":"2463","title":"Reproduction, plants","editor":[{"last_name":"Meyers","full_name":"Meyers, Robert A","first_name":"Robert"}],"publist_id":"4440","author":[{"first_name":"J","last_name":"Dubová","full_name":"Dubová, J"},{"last_name":"Hejátko","full_name":"Hejátko, Jan","first_name":"Jan"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"extern":1,"citation":{"ista":"Dubová J, Hejátko J, Friml J. 2005.Reproduction, plants. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. vol. 12, 249–295.","chicago":"Dubová, J, Jan Hejátko, and Jiří Friml. “Reproduction, Plants.” In Encyclopedia of Molecular Cell Biology and Molecular Medicine, edited by Robert Meyers, 12:249–95. Wiley-Blackwell, 2005. https://doi.org/10.1002/3527600906.","apa":"Dubová, J., Hejátko, J., & Friml, J. (2005). Reproduction, plants. In R. Meyers (Ed.), Encyclopedia of Molecular Cell Biology and Molecular Medicine (Vol. 12, pp. 249–295). Wiley-Blackwell. https://doi.org/10.1002/3527600906","ama":"Dubová J, Hejátko J, Friml J. Reproduction, plants. In: Meyers R, ed. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Vol 12. Wiley-Blackwell; 2005:249-295. doi:10.1002/3527600906","ieee":"J. Dubová, J. Hejátko, and J. Friml, “Reproduction, plants,” in Encyclopedia of Molecular Cell Biology and Molecular Medicine, vol. 12, R. Meyers, Ed. Wiley-Blackwell, 2005, pp. 249–295.","short":"J. Dubová, J. Hejátko, J. Friml, in:, R. Meyers (Ed.), Encyclopedia of Molecular Cell Biology and Molecular Medicine, Wiley-Blackwell, 2005, pp. 249–295.","mla":"Dubová, J., et al. “Reproduction, Plants.” Encyclopedia of Molecular Cell Biology and Molecular Medicine, edited by Robert Meyers, vol. 12, Wiley-Blackwell, 2005, pp. 249–95, doi:10.1002/3527600906."},"date_updated":"2021-01-12T06:57:38Z"},{"title":"Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum","author":[{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"José","last_name":"Albasanz","full_name":"Albasanz, José L"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto"},{"first_name":"José","last_name":"Juíz","full_name":"Juíz, José M"}],"publist_id":"4248","extern":1,"date_updated":"2021-01-12T06:58:48Z","citation":{"ista":"Luján R, Albasanz J, Shigemoto R, Juíz J. 2005. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience. 21(8), 2073–2082.","chicago":"Luján, Rafael, José Albasanz, Ryuichi Shigemoto, and José Juíz. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” European Journal of Neuroscience. Wiley-Blackwell, 2005. https://doi.org/10.1111/j.1460-9568.2005.04043.x.","ama":"Luján R, Albasanz J, Shigemoto R, Juíz J. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience. 2005;21(8):2073-2082. doi:10.1111/j.1460-9568.2005.04043.x","apa":"Luján, R., Albasanz, J., Shigemoto, R., & Juíz, J. (2005). Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2005.04043.x","ieee":"R. Luján, J. Albasanz, R. Shigemoto, and J. Juíz, “Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum,” European Journal of Neuroscience, vol. 21, no. 8. Wiley-Blackwell, pp. 2073–2082, 2005.","short":"R. Luján, J. Albasanz, R. Shigemoto, J. Juíz, European Journal of Neuroscience 21 (2005) 2073–2082.","mla":"Luján, Rafael, et al. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” European Journal of Neuroscience, vol. 21, no. 8, Wiley-Blackwell, 2005, pp. 2073–82, doi:10.1111/j.1460-9568.2005.04043.x."},"status":"public","type":"journal_article","_id":"2648","doi":"10.1111/j.1460-9568.2005.04043.x","volume":21,"issue":"8","date_published":"2005-04-01T00:00:00Z","date_created":"2018-12-11T11:58:52Z","page":"2073 - 2082","day":"01","publication":"European Journal of Neuroscience","publication_status":"published","year":"2005","month":"04","intvolume":" 21","publisher":"Wiley-Blackwell","quality_controlled":0,"abstract":[{"text":"Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are involved in the control of neuronal excitability and plasticity. In this study, we used immunoblotting and immunohistochemical techniques to reveal the developmental expression and subcellular distribution of the HCN1 subunit in the cerebellar cortex. During postnatal development, the spatio-temporal expression of HCN1 correlated well with the morphological events occurring during the ontogenesis of cerebellar interneurons. Using immunoblotting techniques, HCN1 was weakly detected during the first postnatal week and continued to increase throughout postnatal development, peaking at postnatal day (P)15. At the light-microscopic level, HCN1 immunoreactivity was very weak until P7 whereas from P10-12 to adulthood it was strongly detected in the lower third of the molecular layer and in the Purkinje cell layer. HCN1 was present in axons running through the molecular layer and in the pericellular basket around Purkinje cells at P12, but in the periaxonal plexus (the pinceau) surrounding their initial segment only after P15. Using immunofluorescence, HCN1 colocalized with GAD65 and synaptophysin, demonstrating that the subunit was present in inhibitory axons and axon terminals. At the electron-microscopic level, in adulthood, HCN1 immunoparticles were detected at postsynaptic sites in basket and Purkinje cells but most immunoparticles were found at presynaptic sites in basket cell axons and in terminals. In the axon terminals, the distribution of HCN1 was relatively uniform along the extrasynaptic plasma membrane; this was confirmed using quantitative techniques. The present findings suggest that HCN1 channels may provide a significant route for modulating co-ordinated cerebellar synaptic transmission through basket cells.","lang":"eng"}]},{"abstract":[{"text":"Septohippocampal cholinergic neurons play key roles in learning and memory processes, and in the generation of hippocampal theta rhythm. The range of receptors for endogenous modulators expressed on these neurons is unclear. Here we describe GABAB 1a/b receptor (GABABR) and type 1 cannabinoid receptor (CB1R) expression in rat septal cholinergic [i.e. choline acetyltransferase (ChAT)-positive] cells. Using double immunofluorescent staining, we found that almost two-thirds of the cholinergic cells in the rat medial septum were GABABR positive, and that these cells had significantly larger somata than did GABABR-negative cholinergic neurons. We detected CB1R labelling in somata after axonal protein transport was blocked by colchicine. In these animals about one-third of the cholinergic cells were CB1R positive. These cells again had larger somata than CB1R-negative cholinergic neurons. The analyses confirmed that the size of GABABR-positive and CB 1R-positive cholinergic cells were alike, and all CB 1R-positive cholinergic cells were GABABR positive as well. CB1R-positive cells were invariably ChAT positive. All retrogradely labelled septohippocampal cholinergic cells were positive for GABABR and at least half of them also for CB1R. These data shed light on the existence of at least two cholinergic cell types in the medial septum: one expresses GABABR and CB1R, has large somata and projects to the hippocampus, whereas the other is negative for GABABR and CB1R and has smaller somata. The results also suggest that cholinergic transmission in the hippocampus is fine-tuned by endocannabinoid signalling.","lang":"eng"}],"publisher":"Wiley-Blackwell","quality_controlled":0,"month":"06","intvolume":" 21","year":"2005","publication_status":"published","day":"01","publication":"European Journal of Neuroscience","page":"3034 - 3042","doi":"10.1111/j.1460-9568.2005.04146.x","issue":"11","volume":21,"date_published":"2005-06-01T00:00:00Z","date_created":"2018-12-11T11:58:52Z","_id":"2650","type":"journal_article","status":"public","citation":{"mla":"Nyíri, Gábor, et al. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” European Journal of Neuroscience, vol. 21, no. 11, Wiley-Blackwell, 2005, pp. 3034–42, doi:10.1111/j.1460-9568.2005.04146.x.","ieee":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, and T. Freund, “GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons,” European Journal of Neuroscience, vol. 21, no. 11. Wiley-Blackwell, pp. 3034–3042, 2005.","short":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, T. Freund, European Journal of Neuroscience 21 (2005) 3034–3042.","ama":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. European Journal of Neuroscience. 2005;21(11):3034-3042. doi:10.1111/j.1460-9568.2005.04146.x","apa":"Nyíri, G., Szabadits, E., Cserép, C., Mackie, K., Shigemoto, R., & Freund, T. (2005). GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2005.04146.x","chicago":"Nyíri, Gábor, Eszter Szabadits, Csaba Cserép, Ken Mackie, Ryuichi Shigemoto, and Tamás Freund. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” European Journal of Neuroscience. Wiley-Blackwell, 2005. https://doi.org/10.1111/j.1460-9568.2005.04146.x.","ista":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. 2005. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. European Journal of Neuroscience. 21(11), 3034–3042."},"date_updated":"2021-01-12T06:58:49Z","extern":1,"publist_id":"4247","author":[{"first_name":"Gábor","last_name":"Nyíri","full_name":"Nyíri, Gábor"},{"full_name":"Szabadits, Eszter","last_name":"Szabadits","first_name":"Eszter"},{"first_name":"Csaba","full_name":"Cserép, Csaba","last_name":"Cserép"},{"first_name":"Ken","last_name":"Mackie","full_name":"Mackie, Ken P"},{"last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tamás","full_name":"Freund, Tamás F","last_name":"Freund"}],"title":"GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons"},{"type":"review","status":"public","_id":"2647","publist_id":"4250","author":[{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Guillermina","full_name":"López-Bendito, Guillermina","last_name":"López Bendito"}],"title":"Glutamate and GABA receptor signalling in the developing brain","date_updated":"2020-07-14T12:45:44Z","citation":{"apa":"Luján, R., Shigemoto, R., & López Bendito, G. (2005). Glutamate and GABA receptor signalling in the developing brain. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2004.09.042","ama":"Luján R, Shigemoto R, López Bendito G. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 2005;130(3):567-580. doi:10.1016/j.neuroscience.2004.09.042","short":"R. Luján, R. Shigemoto, G. López Bendito, Neuroscience 130 (2005) 567–580.","ieee":"R. Luján, R. Shigemoto, and G. López Bendito, “Glutamate and GABA receptor signalling in the developing brain,” Neuroscience, vol. 130, no. 3. Elsevier, pp. 567–580, 2005.","mla":"Luján, Rafael, et al. “Glutamate and GABA Receptor Signalling in the Developing Brain.” Neuroscience, vol. 130, no. 3, Elsevier, 2005, pp. 567–80, doi:10.1016/j.neuroscience.2004.09.042.","ista":"Luján R, Shigemoto R, López Bendito G. 2005. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 130(3), 567–580.","chicago":"Luján, Rafael, Ryuichi Shigemoto, and Guillermina López Bendito. “Glutamate and GABA Receptor Signalling in the Developing Brain.” Neuroscience. Elsevier, 2005. https://doi.org/10.1016/j.neuroscience.2004.09.042."},"extern":1,"publisher":"Elsevier","quality_controlled":0,"intvolume":" 130","month":"01","abstract":[{"text":"Our understanding of the role played by neurotransmitter receptors in the developing brain has advanced in recent years. The major excitatory and inhibitory neurotransmitters in the brain, glutamate and GABA, activate both ionotropic (ligand-gated ion channels) and metabotropic (G protein-coupled) receptors, and are generally associated with neuronal communication in the mature brain. However, before the emergence of their role in neurotransmission in adulthood, they also act to influence earlier developmental events, some of which occur prior to synapse formation: such as proliferation, migration, differentiation or survival processes during neural development. To fulfill these actions in the constructing of the nervous system, different types of glutamate and GABA receptors need to be expressed both at the right time and at the right place. The identification by molecular cloning of 16 ionotropic glutamate receptor subunits, eight metabotropic glutamate receptor subtypes, 21 ionotropic and two metabotropic GABA receptor subunits, some of which exist in alternatively splice variants, has enriched our appreciation of how molecular diversity leads to functional diversity in the brain. It now appears that many different types of glutamate and GABA receptor subunits have prominent expression in the embryonic and/or postnatal brain, whereas others are mainly present in the adult brain. Although the significance of this differential expression of subunits is not fully understood, it appears that the change in subunit composition is essential for normal development in particular brain regions. This review focuses on emerging information relating to the expression and role of glutamatergic and GABAergic neurotransmitter receptors during prenatal and postnatal development.","lang":"eng"}],"page":"567 - 580","date_created":"2018-12-11T11:58:51Z","issue":"3","doi":"10.1016/j.neuroscience.2004.09.042","volume":130,"date_published":"2005-01-01T00:00:00Z","year":"2005","publication_status":"published","publication":"Neuroscience","day":"01"},{"abstract":[{"text":"The GABAergic system, a major inhibitory regulator in the central nervous system, may also play important roles in peripheral nonneuronal tissues and cells. Recent studies showed that GABAB receptor is expressed in testis and sperm. To understand the role of the GABAergic system in spermiogenesis, we examined cellular localization of GABA and GABAB receptor subunits in rat spermatids by immunocytochemistry. Immunoreactivity for GABA was detected around acrosomal granules of spermatids during the Golgi and cap phases. GABAB(1) immunoreactivity was observed in the acrosomal vesicle of spermatids in Golgi phase, and during cap phase, this reactivity expanded to the entire region of the acrosome covering the nuclear membrane. The level of reactivity decreased gradually with maturation of spermatids. In contrast, GABAB(2) immunoreactivity was not observed in spermatids during Golgi phase but was detected in the equatorial region during cap phase. Both GABA immunoreactivity and GABAB(2) immunoreactivity were transferred to the residual cytoplasm during the release of spermatozoa. Electron microscopic immunocytochemistry revealed that, during cap phase, GABA and GABAB(1) were distributed within the whole acrosomal vesicle but not in the acrosomal granule. GABAB(2) immunoreactivity was observed in the narrow space between the inner acrosomal and nuclear membrane and was limited to the equatorial region of the spermatid head. These results indicate that the GABAergic system might be involved in regulation of spermiogenesis.","lang":"eng"}],"intvolume":" 26","month":"07","publisher":"American Society of Andrology","quality_controlled":0,"publication":"Journal of Andrology","day":"01","publication_status":"published","year":"2005","date_created":"2018-12-11T11:58:52Z","date_published":"2005-07-01T00:00:00Z","issue":"4","volume":26,"doi":"10.2164/jandrol.04185","page":"485 - 493","_id":"2651","status":"public","type":"journal_article","extern":1,"citation":{"ista":"Kanbara K, Okamoto K, Nomura S, Kaneko T, Shigemoto R, Azuma H, Katsuoka Y, Watanabe M. 2005. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. Journal of Andrology. 26(4), 485–493.","chicago":"Kanbara, Kiyoto, Keiko Okamoto, Sakashi Nomura, Takeshi Kaneko, Ryuichi Shigemoto, Haruhito Azuma, Yoji Katsuoka, and Masahiko Watanabe. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” Journal of Andrology. American Society of Andrology, 2005. https://doi.org/10.2164/jandrol.04185.","apa":"Kanbara, K., Okamoto, K., Nomura, S., Kaneko, T., Shigemoto, R., Azuma, H., … Watanabe, M. (2005). Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. Journal of Andrology. American Society of Andrology. https://doi.org/10.2164/jandrol.04185","ama":"Kanbara K, Okamoto K, Nomura S, et al. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. Journal of Andrology. 2005;26(4):485-493. doi:10.2164/jandrol.04185","ieee":"K. Kanbara et al., “Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis,” Journal of Andrology, vol. 26, no. 4. American Society of Andrology, pp. 485–493, 2005.","short":"K. Kanbara, K. Okamoto, S. Nomura, T. Kaneko, R. Shigemoto, H. Azuma, Y. Katsuoka, M. Watanabe, Journal of Andrology 26 (2005) 485–493.","mla":"Kanbara, Kiyoto, et al. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” Journal of Andrology, vol. 26, no. 4, American Society of Andrology, 2005, pp. 485–93, doi:10.2164/jandrol.04185."},"date_updated":"2021-01-12T06:58:50Z","title":"Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis","author":[{"full_name":"Kanbara, Kiyoto","last_name":"Kanbara","first_name":"Kiyoto"},{"last_name":"Okamoto","full_name":"Okamoto, Keiko","first_name":"Keiko"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Haruhito","last_name":"Azuma","full_name":"Azuma, Haruhito"},{"first_name":"Yoji","last_name":"Katsuoka","full_name":"Katsuoka, Yoji"},{"full_name":"Watanabe, Masahiko","last_name":"Watanabe","first_name":"Masahiko"}],"publist_id":"4246"},{"status":"public","type":"journal_article","_id":"2649","title":"Number and density of AMPA receptors in single synapses in immature cerebellum","publist_id":"4249","author":[{"first_name":"Junichi","full_name":"Tanaka, Junichi","last_name":"Tanaka"},{"first_name":"Masanori","last_name":"Matsuzaki","full_name":"Matsuzaki, Masanori"},{"first_name":"Etsuko","full_name":"Tarusawa, Etsuko","last_name":"Tarusawa"},{"first_name":"Akiko","last_name":"Momiyama","full_name":"Momiyama, Akiko"},{"first_name":"Elek","full_name":"Molnár, Elek","last_name":"Molnár"},{"full_name":"Kasai, Haruo","last_name":"Kasai","first_name":"Haruo"},{"last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"extern":1,"citation":{"short":"J. Tanaka, M. Matsuzaki, E. Tarusawa, A. Momiyama, E. Molnár, H. Kasai, R. Shigemoto, Journal of Neuroscience 25 (2005) 799–807.","ieee":"J. Tanaka et al., “Number and density of AMPA receptors in single synapses in immature cerebellum,” Journal of Neuroscience, vol. 25, no. 4. Society for Neuroscience, pp. 799–807, 2005.","apa":"Tanaka, J., Matsuzaki, M., Tarusawa, E., Momiyama, A., Molnár, E., Kasai, H., & Shigemoto, R. (2005). Number and density of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.4256-04.2005","ama":"Tanaka J, Matsuzaki M, Tarusawa E, et al. Number and density of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience. 2005;25(4):799-807. doi:10.1523/JNEUROSCI.4256-04.2005","mla":"Tanaka, Junichi, et al. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” Journal of Neuroscience, vol. 25, no. 4, Society for Neuroscience, 2005, pp. 799–807, doi:10.1523/JNEUROSCI.4256-04.2005.","ista":"Tanaka J, Matsuzaki M, Tarusawa E, Momiyama A, Molnár E, Kasai H, Shigemoto R. 2005. Number and density of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience. 25(4), 799–807.","chicago":"Tanaka, Junichi, Masanori Matsuzaki, Etsuko Tarusawa, Akiko Momiyama, Elek Molnár, Haruo Kasai, and Ryuichi Shigemoto. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.4256-04.2005."},"date_updated":"2021-01-12T06:58:48Z","month":"01","intvolume":" 25","quality_controlled":0,"publisher":"Society for Neuroscience","abstract":[{"text":"The number of ionotropic receptors in synapses is an essential factor for determining the efficacy of fast transmission. We estimated the number of functional AMPA receptors at single postsynaptic sites by a combination of two-photon uncaging of glutamate and the nonstationary fluctuation analysis in immature rat Purkinje cells (PCs), which receive a single type of excitatory input from climbing fibers. Areas of postsynaptic membrane specialization at the recorded synapses were measured by reconstruction of serial ultrathin sections. The number of functional AMPA receptors was proportional to the synaptic area with a density of ∼ 1280 receptors/μm 2. Moreover, highly sensitive freeze-fracture replica labeling revealed a homogeneous density of immunogold particles for AMPA receptors in synaptic sites (910 ± 36 particles/μm 2) and much lower density in extrasynaptic sites (19 ± 2 particles/μm 2) in the immature PCs. Our results indicate that in this developing synapse, the efficacy of transmission is determined by the synaptic area.","lang":"eng"}],"doi":"10.1523/JNEUROSCI.4256-04.2005","issue":"4","volume":25,"date_published":"2005-01-26T00:00:00Z","date_created":"2018-12-11T11:58:52Z","page":"799 - 807","day":"26","publication":"Journal of Neuroscience","year":"2005","publication_status":"published"},{"publication":"Journal of Neuroscience","day":"09","publication_status":"published","year":"2005","date_created":"2018-12-11T11:58:53Z","doi":"10.1523/JNEUROSCI.2547-05.2005","date_published":"2005-11-09T00:00:00Z","volume":25,"issue":"45","page":"10520 - 10536","abstract":[{"text":"Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.","lang":"eng"}],"intvolume":" 25","month":"11","publisher":"Society for Neuroscience","quality_controlled":0,"extern":1,"date_updated":"2021-01-12T06:58:51Z","citation":{"mla":"Ferraguti, Francesco, et al. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” Journal of Neuroscience, vol. 25, no. 45, Society for Neuroscience, 2005, pp. 10520–36, doi:10.1523/JNEUROSCI.2547-05.2005.","ama":"Ferraguti F, Klausberger T, Cobden P, et al. Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 2005;25(45):10520-10536. doi:10.1523/JNEUROSCI.2547-05.2005","apa":"Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J., Szűcs, P., … Dalezios, Y. (2005). Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.2547-05.2005","short":"F. Ferraguti, T. Klausberger, P. Cobden, A. Baude, J. Roberts, P. Szűcs, A. Kinoshita, R. Shigemoto, P. Somogyi, Y. Dalezios, Journal of Neuroscience 25 (2005) 10520–10536.","ieee":"F. Ferraguti et al., “ Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus,” Journal of Neuroscience, vol. 25, no. 45. Society for Neuroscience, pp. 10520–10536, 2005.","chicago":"Ferraguti, Francesco, Thomas Klausberger, Philip Cobden, Agnès Baude, John Roberts, Péter Szűcs, Ayae Kinoshita, Ryuichi Shigemoto, Péter Somogyi, and Yannis Dalezios. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.2547-05.2005.","ista":"Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts J, Szűcs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y. 2005. Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 25(45), 10520–10536."},"title":" Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus","author":[{"full_name":"Ferraguti, Francesco","last_name":"Ferraguti","first_name":"Francesco"},{"first_name":"Thomas","last_name":"Klausberger","full_name":"Klausberger,Thomas"},{"full_name":"Cobden, Philip M","last_name":"Cobden","first_name":"Philip"},{"full_name":"Baude, Agnès","last_name":"Baude","first_name":"Agnès"},{"last_name":"Roberts","full_name":"Roberts, John D","first_name":"John"},{"last_name":"Szűcs","full_name":"Szűcs, Péter","first_name":"Péter"},{"first_name":"Ayae","last_name":"Kinoshita","full_name":"Kinoshita, Ayae"},{"last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Péter","full_name":"Somogyi, Péter","last_name":"Somogyi"},{"last_name":"Dalezios","full_name":"Dalezios, Yannis","first_name":"Yannis"}],"publist_id":"4242","_id":"2654","status":"public","type":"journal_article"},{"type":"journal_article","status":"public","_id":"2658","publist_id":"4240","author":[{"first_name":"Katsuyuki","full_name":"Kaneda, Katsuyuki","last_name":"Kaneda"},{"first_name":"Yoshihisa","last_name":"Tachibana","full_name":"Tachibana, Yoshihisa"},{"last_name":"Imanishi","full_name":"Imanishi, Michiko","first_name":"Michiko"},{"first_name":"Hitoshi","last_name":"Kita","full_name":"Kita, Hitoshi"},{"full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Atsushi","full_name":"Nambu, Atsushi","last_name":"Nambu"},{"last_name":"Takada","full_name":"Takada, Masahiko","first_name":"Masahiko"}],"title":"Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys","citation":{"ista":"Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, Takada M. 2005. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. European Journal of Neuroscience. 22(12), 3241–3254.","chicago":"Kaneda, Katsuyuki, Yoshihisa Tachibana, Michiko Imanishi, Hitoshi Kita, Ryuichi Shigemoto, Atsushi Nambu, and Masahiko Takada. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” European Journal of Neuroscience. Wiley-Blackwell, 2005. https://doi.org/10.1111/j.1460-9568.2005.04488.x.","short":"K. Kaneda, Y. Tachibana, M. Imanishi, H. Kita, R. Shigemoto, A. Nambu, M. Takada, European Journal of Neuroscience 22 (2005) 3241–3254.","ieee":"K. Kaneda et al., “Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys,” European Journal of Neuroscience, vol. 22, no. 12. Wiley-Blackwell, pp. 3241–3254, 2005.","apa":"Kaneda, K., Tachibana, Y., Imanishi, M., Kita, H., Shigemoto, R., Nambu, A., & Takada, M. (2005). Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2005.04488.x","ama":"Kaneda K, Tachibana Y, Imanishi M, et al. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. European Journal of Neuroscience. 2005;22(12):3241-3254. doi:10.1111/j.1460-9568.2005.04488.x","mla":"Kaneda, Katsuyuki, et al. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” European Journal of Neuroscience, vol. 22, no. 12, Wiley-Blackwell, 2005, pp. 3241–54, doi:10.1111/j.1460-9568.2005.04488.x."},"date_updated":"2021-01-12T06:58:52Z","extern":1,"quality_controlled":0,"publisher":"Wiley-Blackwell","intvolume":" 22","month":"12","abstract":[{"lang":"eng","text":"Enhanced glutamatergic neurotransmission via the subthalamopallidal or subthalamonigral projection seems crucial for developing parkinsonian motor signs. In the present study, the possible changes in the expression of metabotropic glutamate receptors (mGluRs) were examined in the basal ganglia of a primate model for Parkinson's disease. When the patterns of immunohistochemical localization of mGluRs in monkeys administered systemically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were analysed in comparison with normal controls, we found that expression of mGluR1α, but not of other subtypes, was significantly reduced in the internal and external segments of the globus pallidus and the substantia nigra pars reticulata. To elucidate the functional role of mGluR1 in the control of pallidal neuron activity, extracellular unit recordings combined with intrapallidal microinjections of mGluR1-related agents were then performed in normal and parkinsonian monkeys. In normal awake conditions, the spontaneous firing rates of neurons in the pallidal complex were increased by DHPG, a selective agonist of group I mGluRs, whereas they were decreased by AIDA, a selective antagonist of group I mGluRs, or LY367385, a selective antagonist of mGluR1. These electrophysiological data strongly indicate that the excitatory mechanism of pallidal neurons by glutamate is mediated at least partly through mGluR1. The effects of the mGluR1-related agents on neuronal firing in the internal pallidal segment became rather obscure after MPTP treatment. Our results suggest that the specific down-regulation of pallidal and nigral mGluR1 ot in the parkinsonian state may exert a compensatory action to reverse the overactivity of the subthalamic nucleus-derived glutamatergic input that is generated in the disease."}],"page":"3241 - 3254","date_created":"2018-12-11T11:58:55Z","doi":"10.1111/j.1460-9568.2005.04488.x","issue":"12","date_published":"2005-12-01T00:00:00Z","volume":22,"publication_status":"published","year":"2005","publication":"European Journal of Neuroscience","day":"01"},{"page":"6775 - 6786","volume":25,"date_published":"2005-07-20T00:00:00Z","issue":"29","doi":"10.1523/JNEUROSCI.1135-05.2005","date_created":"2018-12-11T11:58:53Z","publication_status":"published","year":"2005","day":"20","publication":"Journal of Neuroscience","publisher":"Society for Neuroscience","quality_controlled":0,"month":"07","intvolume":" 25","abstract":[{"lang":"eng","text":"We studied neurogliaform neurons in the stratum lacunosum moleculare of the CA1 hippocampal area. These interneurons have short stellate dendrites and an extensive axonal arbor mainly located in the stratum lacunosum moleculare. Single-cell reverse transcription-PCR showed that these neurons were GABAergic and that the majority expressed mRNA for neuropeptide Y. Most neurogliaform neurons tested were immunoreactive for α-actinin-2, and many stratum lacunosum moleculare interneurons coexpressed α-actinin-2 and neuropeptide Y. Neurogliaform neurons received monosynaptic, DNQX-sensitive excitatory input from the perforant path, and 40 Hz stimulation of this input evoked EPSCs displaying either depression or initial facilitation, followed by depression. Paired recordings performed between neurogliaform neurons showed that 85% of pairs were electrically connected and 70% were also connected via GABAergic synapses. Injection of sine waveforms into neurons during paired recordings resulted in transmission of the waveforms through the electrical synapse. Unitary IPSCs recorded from neurogliaform pairs readily fatigued, had a slow decay, and had a strong depression of the synaptic response at a 5 Hz stimulation frequency that was antagonized by the GABA B antagonist (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl) phosphinic acid (CGP55845). The amplitude of the first IPSC during the 5 Hz stimulation was also increased by CGP55845, suggesting a tonic inhibition of synaptic transmission. A small unitary GABA B-mediated IPSC could also be detected, providing the first evidence for such a component between GABAergic interneurons. Electron microscopic localization of the GABA B1 subunit at neurogliaform synapses revealed the protein in both presynaptic and postsynaptic membranes. Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus."}],"publist_id":"4245","author":[{"full_name":"Price, Christopher J","last_name":"Price","first_name":"Christopher"},{"full_name":"Cauli, Bruno","last_name":"Cauli","first_name":"Bruno"},{"first_name":"Endre","full_name":"Kovács, Endre R","last_name":"Kovács"},{"first_name":"Ákos","full_name":"Kulik, Ákos","last_name":"Kulik"},{"full_name":"Lambolez, Bertrand","last_name":"Lambolez","first_name":"Bertrand"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Marco","full_name":"Capogna,Marco","last_name":"Capogna"}],"title":"Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area","citation":{"ista":"Price C, Cauli B, Kovács E, Kulik Á, Lambolez B, Shigemoto R, Capogna M. 2005. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. Journal of Neuroscience. 25(29), 6775–6786.","chicago":"Price, Christopher, Bruno Cauli, Endre Kovács, Ákos Kulik, Bertrand Lambolez, Ryuichi Shigemoto, and Marco Capogna. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.1135-05.2005.","ieee":"C. Price et al., “Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area,” Journal of Neuroscience, vol. 25, no. 29. Society for Neuroscience, pp. 6775–6786, 2005.","short":"C. Price, B. Cauli, E. Kovács, Á. Kulik, B. Lambolez, R. Shigemoto, M. Capogna, Journal of Neuroscience 25 (2005) 6775–6786.","apa":"Price, C., Cauli, B., Kovács, E., Kulik, Á., Lambolez, B., Shigemoto, R., & Capogna, M. (2005). Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1135-05.2005","ama":"Price C, Cauli B, Kovács E, et al. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. Journal of Neuroscience. 2005;25(29):6775-6786. doi:10.1523/JNEUROSCI.1135-05.2005","mla":"Price, Christopher, et al. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” Journal of Neuroscience, vol. 25, no. 29, Society for Neuroscience, 2005, pp. 6775–86, doi:10.1523/JNEUROSCI.1135-05.2005."},"date_updated":"2021-01-12T06:58:50Z","extern":1,"type":"journal_article","status":"public","_id":"2652"}]