--- _id: '11762' abstract: - lang: eng text: 'In this paper, we describe six algorithmic problems that arise in web search engines and that are not or only partially solved: (1) Uniformly sampling of web pages; (2) modeling the web graph; (3) finding duplicate hosts; (4) finding top gainers and losers in data streams; (5) finding large dense bipartite graphs; and (6) understanding how eigenvectors partition the web.' article_processing_charge: No article_type: original author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 citation: ama: Henzinger MH. Algorithmic challenges in web search engines. Internet Mathematics. 2004;1(1):115-123. doi:10.1080/15427951.2004.10129079 apa: Henzinger, M. H. (2004). Algorithmic challenges in web search engines. Internet Mathematics. Internet Mathematics. https://doi.org/10.1080/15427951.2004.10129079 chicago: Henzinger, Monika H. “Algorithmic Challenges in Web Search Engines.” Internet Mathematics. Internet Mathematics, 2004. https://doi.org/10.1080/15427951.2004.10129079. ieee: M. H. Henzinger, “Algorithmic challenges in web search engines,” Internet Mathematics, vol. 1, no. 1. Internet Mathematics, pp. 115–123, 2004. ista: Henzinger MH. 2004. Algorithmic challenges in web search engines. Internet Mathematics. 1(1), 115–123. mla: Henzinger, Monika H. “Algorithmic Challenges in Web Search Engines.” Internet Mathematics, vol. 1, no. 1, Internet Mathematics, 2004, pp. 115–23, doi:10.1080/15427951.2004.10129079. short: M.H. Henzinger, Internet Mathematics 1 (2004) 115–123. date_created: 2022-08-08T11:55:53Z date_published: 2004-01-01T00:00:00Z date_updated: 2023-02-10T07:47:21Z day: '01' doi: 10.1080/15427951.2004.10129079 extern: '1' intvolume: ' 1' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1080/15427951.2004.10129079 month: '01' oa: 1 oa_version: Published Version page: 115-123 publication: Internet Mathematics publication_identifier: eissn: - 1944-9488 issn: - 1542-7951 publication_status: published publisher: Internet Mathematics quality_controlled: '1' scopus_import: '1' status: public title: Algorithmic challenges in web search engines type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 1 year: '2004' ... --- _id: '11801' abstract: - lang: eng text: "Web search engines have emerged as one of the central applications on the internet. In fact, search has become one of the most important activities that people engage in on the Internet. Even beyond becoming the number one source of information, a growing number of businesses are depending on web search engines for customer acquisition. In this talk I will brief review the history of web search engines: The first generation of web search engines used text-only retrieval techniques. Google revolutionized the field by deploying the PageRank technology – an eigenvector-based analysis of the hyperlink structure- to analyze the web in order to produce relevant results. Moving forward, our goal is to achieve a better understanding of a page with a view towards producing even more relevant results.\r\n\r\nGoogle is powered by a large number of PCs. Using this infrastructure and striving to be as efficient as possible poses challenging systems problems but also various algorithmic challenges. I will discuss some of them in my talk." alternative_title: - LNCS article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 citation: ama: 'Henzinger MH. Algorithmic aspects of web search engines. In: 2th Annual European Symposium on Algorithms. Vol 3221. Springer Nature; 2004:3. doi:10.1007/978-3-540-30140-0_2' apa: 'Henzinger, M. H. (2004). Algorithmic aspects of web search engines. In 2th Annual European Symposium on Algorithms (Vol. 3221, p. 3). Bergen, Norway: Springer Nature. https://doi.org/10.1007/978-3-540-30140-0_2' chicago: Henzinger, Monika H. “Algorithmic Aspects of Web Search Engines.” In 2th Annual European Symposium on Algorithms, 3221:3. Springer Nature, 2004. https://doi.org/10.1007/978-3-540-30140-0_2. ieee: M. H. Henzinger, “Algorithmic aspects of web search engines,” in 2th Annual European Symposium on Algorithms, Bergen, Norway, 2004, vol. 3221, p. 3. ista: 'Henzinger MH. 2004. Algorithmic aspects of web search engines. 2th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms, LNCS, vol. 3221, 3.' mla: Henzinger, Monika H. “Algorithmic Aspects of Web Search Engines.” 2th Annual European Symposium on Algorithms, vol. 3221, Springer Nature, 2004, p. 3, doi:10.1007/978-3-540-30140-0_2. short: M.H. Henzinger, in:, 2th Annual European Symposium on Algorithms, Springer Nature, 2004, p. 3. conference: end_date: 2004-09-17 location: Bergen, Norway name: 'ESA: European Symposium on Algorithms' start_date: 2004-09-14 date_created: 2022-08-11T13:18:05Z date_published: 2004-09-01T00:00:00Z date_updated: 2023-02-13T11:47:26Z day: '01' doi: 10.1007/978-3-540-30140-0_2 extern: '1' intvolume: ' 3221' language: - iso: eng month: '09' oa_version: None page: '3' publication: 2th Annual European Symposium on Algorithms publication_identifier: eissn: - 1611-3349 isbn: - ' 3540230254' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Algorithmic aspects of web search engines type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 3221 year: '2004' ... --- _id: '11800' abstract: - lang: eng text: "Web search engines have emerged as one of the central applications on the Internet. In fact, search has become one of the most important activities that people engage in on the the Internet. Even beyond becoming the number one source of information, a growing number of businesses are depending on web search engines for customer acquisition.\r\n\r\nThe first generation of web search engines used text-only retrieval techniques. Google revolutionized the field by deploying the PageRank technology – an eigenvector-based analysis of the hyperlink structure – to analyze the web in order to produce relevant results. Moving forward, our goal is to achieve a better understanding of a page with a view towards producing even more relevant results." alternative_title: - LNCS article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 citation: ama: 'Henzinger MH. The past, present, and future of web search engines. In: 31st International Colloquium on Automata, Languages and Programming. Vol 3142. Springer Nature; 2004:3. doi:10.1007/978-3-540-27836-8_2' apa: 'Henzinger, M. H. (2004). The past, present, and future of web search engines. In 31st International Colloquium on Automata, Languages and Programming (Vol. 3142, p. 3). Turku, Finland: Springer Nature. https://doi.org/10.1007/978-3-540-27836-8_2' chicago: Henzinger, Monika H. “The Past, Present, and Future of Web Search Engines.” In 31st International Colloquium on Automata, Languages and Programming, 3142:3. Springer Nature, 2004. https://doi.org/10.1007/978-3-540-27836-8_2. ieee: M. H. Henzinger, “The past, present, and future of web search engines,” in 31st International Colloquium on Automata, Languages and Programming, Turku, Finland, 2004, vol. 3142, p. 3. ista: 'Henzinger MH. 2004. The past, present, and future of web search engines. 31st International Colloquium on Automata, Languages and Programming. ICALP: International Colloquium on Automata, Languages, and Programming, LNCS, vol. 3142, 3.' mla: Henzinger, Monika H. “The Past, Present, and Future of Web Search Engines.” 31st International Colloquium on Automata, Languages and Programming, vol. 3142, Springer Nature, 2004, p. 3, doi:10.1007/978-3-540-27836-8_2. short: M.H. Henzinger, in:, 31st International Colloquium on Automata, Languages and Programming, Springer Nature, 2004, p. 3. conference: end_date: 2004-07-16 location: Turku, Finland name: 'ICALP: International Colloquium on Automata, Languages, and Programming' start_date: 2004-07-12 date_created: 2022-08-11T12:38:58Z date_published: 2004-07-01T00:00:00Z date_updated: 2023-02-13T11:45:25Z day: '01' doi: 10.1007/978-3-540-27836-8_2 extern: '1' intvolume: ' 3142' language: - iso: eng month: '07' oa_version: None page: '3' publication: 31st International Colloquium on Automata, Languages and Programming publication_identifier: eissn: - 1611-3349 issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The past, present, and future of web search engines type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 3142 year: '2004' ... --- _id: '11859' abstract: - lang: eng text: In this article we describe the approach taken by the first web search engines, discuss the state of the art, and present some of the challenges for the future. article_processing_charge: No author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 citation: ama: 'Henzinger MH. The past, present, and future of web information retrieval. In: SPIE Proceedings. Vol 5296. Society of Photo-Optical Instrumentation Engineers; 2004:23-26. doi:10.1117/12.537534' apa: 'Henzinger, M. H. (2004). The past, present, and future of web information retrieval. In SPIE Proceedings (Vol. 5296, pp. 23–26). San Jose, CA, United States: Society of Photo-Optical Instrumentation Engineers. https://doi.org/10.1117/12.537534' chicago: Henzinger, Monika H. “The Past, Present, and Future of Web Information Retrieval.” In SPIE Proceedings, 5296:23–26. Society of Photo-Optical Instrumentation Engineers, 2004. https://doi.org/10.1117/12.537534. ieee: M. H. Henzinger, “The past, present, and future of web information retrieval,” in SPIE Proceedings, San Jose, CA, United States, 2004, vol. 5296, pp. 23–26. ista: Henzinger MH. 2004. The past, present, and future of web information retrieval. SPIE Proceedings. Document Recognition and Retrieval XI vol. 5296, 23–26. mla: Henzinger, Monika H. “The Past, Present, and Future of Web Information Retrieval.” SPIE Proceedings, vol. 5296, Society of Photo-Optical Instrumentation Engineers, 2004, pp. 23–26, doi:10.1117/12.537534. short: M.H. Henzinger, in:, SPIE Proceedings, Society of Photo-Optical Instrumentation Engineers, 2004, pp. 23–26. conference: end_date: 2004-01-22 location: San Jose, CA, United States name: Document Recognition and Retrieval XI start_date: 2004-01-21 date_created: 2022-08-16T08:46:41Z date_published: 2004-01-01T00:00:00Z date_updated: 2023-02-17T10:05:19Z day: '01' doi: 10.1117/12.537534 extern: '1' intvolume: ' 5296' language: - iso: eng month: '01' oa_version: None page: 23 - 26 publication: SPIE Proceedings publication_identifier: issn: - 0277-786X publication_status: published publisher: Society of Photo-Optical Instrumentation Engineers quality_controlled: '1' scopus_import: '1' status: public title: The past, present, and future of web information retrieval type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 5296 year: '2004' ... --- _id: '11877' abstract: - lang: eng text: The World Wide Web provides a unprecedented opportunity to automatically analyze a large sample of interests and activity in the world. We discuss methods for extracting knowledge from the web by randomly sampling and analyzing hosts and pages, and by analyzing the link structure of the web and how links accumulate over time. A variety of interesting and valuable information can be extracted, such as the distribution of web pages over domains, the distribution of interest in different areas, communities related to different topics, the nature of competition in different categories of sites, and the degree of communication between different communities or countries. article_processing_charge: No article_type: original author: - first_name: Monika H full_name: Henzinger, Monika H id: 540c9bbd-f2de-11ec-812d-d04a5be85630 last_name: Henzinger orcid: 0000-0002-5008-6530 - first_name: Steve full_name: Lawrence, Steve last_name: Lawrence citation: ama: Henzinger MH, Lawrence S. Extracting knowledge from the World Wide Web. Proceedings of the National Academy of Sciences. 2004;101(suppl_1):5186-5191. doi:10.1073/pnas.0307528100 apa: Henzinger, M. H., & Lawrence, S. (2004). Extracting knowledge from the World Wide Web. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307528100 chicago: Henzinger, Monika H, and Steve Lawrence. “Extracting Knowledge from the World Wide Web.” Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences, 2004. https://doi.org/10.1073/pnas.0307528100. ieee: M. H. Henzinger and S. Lawrence, “Extracting knowledge from the World Wide Web,” Proceedings of the National Academy of Sciences, vol. 101, no. suppl_1. Proceedings of the National Academy of Sciences, pp. 5186–5191, 2004. ista: Henzinger MH, Lawrence S. 2004. Extracting knowledge from the World Wide Web. Proceedings of the National Academy of Sciences. 101(suppl_1), 5186–5191. mla: Henzinger, Monika H., and Steve Lawrence. “Extracting Knowledge from the World Wide Web.” Proceedings of the National Academy of Sciences, vol. 101, no. suppl_1, Proceedings of the National Academy of Sciences, 2004, pp. 5186–91, doi:10.1073/pnas.0307528100. short: M.H. Henzinger, S. Lawrence, Proceedings of the National Academy of Sciences 101 (2004) 5186–5191. date_created: 2022-08-16T13:06:10Z date_published: 2004-04-06T00:00:00Z date_updated: 2023-02-17T12:21:43Z day: '06' doi: 10.1073/pnas.0307528100 extern: '1' external_id: pmid: - '14745041' intvolume: ' 101' issue: suppl_1 language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387294/ month: '04' oa: 1 oa_version: Published Version page: 5186-5191 pmid: 1 publication: Proceedings of the National Academy of Sciences publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: Proceedings of the National Academy of Sciences quality_controlled: '1' scopus_import: '1' status: public title: Extracting knowledge from the World Wide Web type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 101 year: '2004' ... --- _id: '12658' abstract: - lang: eng text: '[1] During the ablation period 2001 a glaciometeorological experiment was carried out on Haut Glacier d''Arolla, Switzerland. Five meteorological stations were installed on the glacier, and one permanent automatic weather station in the glacier foreland. The altitudes of the stations ranged between 2500 and 3000 m a.s.l., and they were in operation from end of May to beginning of September 2001. The spatial arrangement of the stations and temporal duration of the measurements generated a unique data set enabling the analysis of the spatial and temporal variability of the meteorological variables across an alpine glacier. All measurements were taken at a nominal height of 2 m, and hourly averages were derived for the analysis. The wind regime was dominated by the glacier wind (mean value 2.8 m s−1) but due to erosion by the synoptic gradient wind, occasionally the wind would blow up the valley. A slight decrease in mean 2 m air temperatures with altitude was found, however the 2 m air temperature gradient varied greatly and frequently changed its sign. Mean relative humidity was 71% and exhibited limited spatial variation. Mean incoming shortwave radiation and albedo both generally increased with elevation. The different components of shortwave radiation are quantified with a parameterization scheme. Resulting spatial variations are mainly due to horizon obstruction and reflections from surrounding slopes, i.e., topography. The effect of clouds accounts for a loss of 30% of the extraterrestrial flux. Albedos derived from a Landsat TM image of 30 July show remarkably constant values, in the range 0.49 to 0.50, across snow covered parts of the glacier, while albedo is highly spatially variable below the zone of continuous snow cover. These results are verified with ground measurements and compared with parameterized albedo. Mean longwave radiative fluxes decreased with elevation due to lower air temperatures and the effect of upper hemisphere slopes. It is shown through parameterization that this effect would even be more pronounced without the effect of clouds. Results are discussed with respect to a similar study which has been carried out on Pasterze Glacier (Austria). The presented algorithms for interpolating, parameterizing and simulating variables and parameters in alpine regions are integrated in the software package AMUNDSEN which is freely available to be adapted and further developed by the community.' article_number: D03103 article_processing_charge: No article_type: original author: - first_name: Ulrich full_name: Strasser, Ulrich last_name: Strasser - first_name: Javier full_name: Corripio, Javier last_name: Corripio - first_name: Francesca full_name: Pellicciotti, Francesca id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70 last_name: Pellicciotti - first_name: Paolo full_name: Burlando, Paolo last_name: Burlando - first_name: Ben full_name: Brock, Ben last_name: Brock - first_name: Martin full_name: Funk, Martin last_name: Funk citation: ama: 'Strasser U, Corripio J, Pellicciotti F, Burlando P, Brock B, Funk M. Spatial and temporal variability of meteorological variables at Haut Glacier d’Arolla (Switzerland) during the ablation season 2001: Measurements and simulations. Journal of Geophysical Research: Atmospheres. 2004;109(D3). doi:10.1029/2003jd003973' apa: 'Strasser, U., Corripio, J., Pellicciotti, F., Burlando, P., Brock, B., & Funk, M. (2004). Spatial and temporal variability of meteorological variables at Haut Glacier d’Arolla (Switzerland) during the ablation season 2001: Measurements and simulations. Journal of Geophysical Research: Atmospheres. American Geophysical Union. https://doi.org/10.1029/2003jd003973' chicago: 'Strasser, Ulrich, Javier Corripio, Francesca Pellicciotti, Paolo Burlando, Ben Brock, and Martin Funk. “Spatial and Temporal Variability of Meteorological Variables at Haut Glacier d’Arolla (Switzerland) during the Ablation Season 2001: Measurements and Simulations.” Journal of Geophysical Research: Atmospheres. American Geophysical Union, 2004. https://doi.org/10.1029/2003jd003973.' ieee: 'U. Strasser, J. Corripio, F. Pellicciotti, P. Burlando, B. Brock, and M. Funk, “Spatial and temporal variability of meteorological variables at Haut Glacier d’Arolla (Switzerland) during the ablation season 2001: Measurements and simulations,” Journal of Geophysical Research: Atmospheres, vol. 109, no. D3. American Geophysical Union, 2004.' ista: 'Strasser U, Corripio J, Pellicciotti F, Burlando P, Brock B, Funk M. 2004. Spatial and temporal variability of meteorological variables at Haut Glacier d’Arolla (Switzerland) during the ablation season 2001: Measurements and simulations. Journal of Geophysical Research: Atmospheres. 109(D3), D03103.' mla: 'Strasser, Ulrich, et al. “Spatial and Temporal Variability of Meteorological Variables at Haut Glacier d’Arolla (Switzerland) during the Ablation Season 2001: Measurements and Simulations.” Journal of Geophysical Research: Atmospheres, vol. 109, no. D3, D03103, American Geophysical Union, 2004, doi:10.1029/2003jd003973.' short: 'U. Strasser, J. Corripio, F. Pellicciotti, P. Burlando, B. Brock, M. Funk, Journal of Geophysical Research: Atmospheres 109 (2004).' date_created: 2023-02-20T08:18:57Z date_published: 2004-02-16T00:00:00Z date_updated: 2023-02-20T08:40:21Z day: '16' doi: 10.1029/2003jd003973 extern: '1' intvolume: ' 109' issue: D3 keyword: - Paleontology - Space and Planetary Science - Earth and Planetary Sciences (miscellaneous) - Atmospheric Science - Earth-Surface Processes - Geochemistry and Petrology - Soil Science - Water Science and Technology - Ecology - Aquatic Science - Forestry - Oceanography - Geophysics language: - iso: eng month: '02' oa_version: None publication: 'Journal of Geophysical Research: Atmospheres' publication_identifier: issn: - 0148-0227 publication_status: published publisher: American Geophysical Union quality_controlled: '1' scopus_import: '1' status: public title: 'Spatial and temporal variability of meteorological variables at Haut Glacier d''Arolla (Switzerland) during the ablation season 2001: Measurements and simulations' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 109 year: '2004' ... --- _id: '1456' abstract: - lang: eng text: We study the space of L2 harmonic forms on complete manifolds with metrics of fibred boundary or fibred cusp type. These metrics generalize the geometric structures at infinity of several different well-known classes of metrics, including asymptotically locally Euclidean manifolds, the (known types of) gravitational instantons, and also Poincaré metrics on ℚ-rank 1 ends of locally symmetric spaces and on the complements of smooth divisors in Kähler manifolds. The answer in all cases is given in terms of intersection cohomology of a stratified compactification of the manifold. The L2 signature formula implied by our result is closely related to the one proved by Dai and more generally by Vaillant and identifies Dai's τ-invariant directly in terms of intersection cohomology of differing perversities. This work is also closely related to a recent paper of Carron and the forthcoming paper of Cheeger and Dai. We apply our results to a number of examples, gravitational instantons among them, arising in predictions about L2 harmonic forms in duality theories in string theory. acknowledgement: |- Hausel’s work supported by a Miller Research Fellowship at the University of California, Berkeley. Hunsicker’s work partially supported by Stanford University. Mazzeo’s work supported by National Science Foundation grant numbers DMS-991975 and DMS-0204730 and by the Mathematical Sciences Research Institute. author: - first_name: Tamas full_name: Tamas Hausel id: 4A0666D8-F248-11E8-B48F-1D18A9856A87 last_name: Hausel - first_name: Eugénie full_name: Hunsicker, Eugénie last_name: Hunsicker - first_name: Rafe full_name: Mazzeo, Rafe R last_name: Mazzeo citation: ama: Hausel T, Hunsicker E, Mazzeo R. Hodge cohomology of gravitational instantons. Duke Mathematical Journal. 2004;122(3):485-548. doi:10.1215/S0012-7094-04-12233-X apa: Hausel, T., Hunsicker, E., & Mazzeo, R. (2004). Hodge cohomology of gravitational instantons. Duke Mathematical Journal. Duke University Press. https://doi.org/10.1215/S0012-7094-04-12233-X chicago: Hausel, Tamás, Eugénie Hunsicker, and Rafe Mazzeo. “Hodge Cohomology of Gravitational Instantons.” Duke Mathematical Journal. Duke University Press, 2004. https://doi.org/10.1215/S0012-7094-04-12233-X. ieee: T. Hausel, E. Hunsicker, and R. Mazzeo, “Hodge cohomology of gravitational instantons,” Duke Mathematical Journal, vol. 122, no. 3. Duke University Press, pp. 485–548, 2004. ista: Hausel T, Hunsicker E, Mazzeo R. 2004. Hodge cohomology of gravitational instantons. Duke Mathematical Journal. 122(3), 485–548. mla: Hausel, Tamás, et al. “Hodge Cohomology of Gravitational Instantons.” Duke Mathematical Journal, vol. 122, no. 3, Duke University Press, 2004, pp. 485–548, doi:10.1215/S0012-7094-04-12233-X. short: T. Hausel, E. Hunsicker, R. Mazzeo, Duke Mathematical Journal 122 (2004) 485–548. date_created: 2018-12-11T11:52:08Z date_published: 2004-04-15T00:00:00Z date_updated: 2021-01-12T06:50:52Z day: '15' doi: 10.1215/S0012-7094-04-12233-X extern: 1 intvolume: ' 122' issue: '3' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math/0207169 month: '04' oa: 1 page: 485 - 548 publication: Duke Mathematical Journal publication_status: published publisher: Duke University Press publist_id: '5737' quality_controlled: 0 status: public title: Hodge cohomology of gravitational instantons type: journal_article volume: 122 year: '2004' ... --- _id: '1464' abstract: - lang: eng text: "The moduli space of stable vector bundles on a Riemann surface is smooth when the rank and degree are coprime, and is diffeomorphic to the space of unitary connections of central constant curvature. A classic result of Newstead and Atiyah and Bott asserts that its rational cohomology ring is generated by the universal classes, that is, by the Kunneth components of the Chern classes of the universal bundle.\n\nThis paper studies the larger, non-compact moduli space of Higgs bundles, as introduced by Hitchin and Simpson, with values in the canonical bundle K. This is diffeomorphic to the space of all connections of central constant curvature, whether unitary or not. The main result of the paper is that, in the rank 2 case, the rational cohomology ring of this space is again generated by universal classes.\n\nThe spaces of Higgs bundles with values in K(n) for n > 0 turn out to be essential to the story. Indeed, we show that their direct limit has the homotopy type of the classifying space of the gauge group, and hence has cohomology generated by universal classes. 2000 Mathematics Subject Classification 14H60 (primary), 14D20, 14H81, 32Q55, 58D27 (secondary). " author: - first_name: Tamas full_name: Tamas Hausel id: 4A0666D8-F248-11E8-B48F-1D18A9856A87 last_name: Hausel - first_name: Michael full_name: Thaddeus, Michael last_name: Thaddeus citation: ama: Hausel T, Thaddeus M. Generators for the cohomology ring of the moduli space of rank 2 higgs bundles. Proceedings of the London Mathematical Society. 2004;88(3):632-658. doi:10.1112/S0024611503014618 apa: Hausel, T., & Thaddeus, M. (2004). Generators for the cohomology ring of the moduli space of rank 2 higgs bundles. Proceedings of the London Mathematical Society. Oxford University Press. https://doi.org/10.1112/S0024611503014618 chicago: Hausel, Tamás, and Michael Thaddeus. “Generators for the Cohomology Ring of the Moduli Space of Rank 2 Higgs Bundles.” Proceedings of the London Mathematical Society. Oxford University Press, 2004. https://doi.org/10.1112/S0024611503014618. ieee: T. Hausel and M. Thaddeus, “Generators for the cohomology ring of the moduli space of rank 2 higgs bundles,” Proceedings of the London Mathematical Society, vol. 88, no. 3. Oxford University Press, pp. 632–658, 2004. ista: Hausel T, Thaddeus M. 2004. Generators for the cohomology ring of the moduli space of rank 2 higgs bundles. Proceedings of the London Mathematical Society. 88(3), 632–658. mla: Hausel, Tamás, and Michael Thaddeus. “Generators for the Cohomology Ring of the Moduli Space of Rank 2 Higgs Bundles.” Proceedings of the London Mathematical Society, vol. 88, no. 3, Oxford University Press, 2004, pp. 632–58, doi:10.1112/S0024611503014618. short: T. Hausel, M. Thaddeus, Proceedings of the London Mathematical Society 88 (2004) 632–658. date_created: 2018-12-11T11:52:10Z date_published: 2004-05-01T00:00:00Z date_updated: 2021-01-12T06:50:55Z day: '01' doi: 10.1112/S0024611503014618 extern: 1 intvolume: ' 88' issue: '3' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math/0003093 month: '05' oa: 1 page: 632 - 658 publication: Proceedings of the London Mathematical Society publication_status: published publisher: Oxford University Press publist_id: '5736' quality_controlled: 0 status: public title: Generators for the cohomology ring of the moduli space of rank 2 higgs bundles type: journal_article volume: 88 year: '2004' ... --- _id: '1963' abstract: - lang: eng text: The mechanism coupling electron transfer and proton pumping in respiratory complex I (NADH-ubiquinone oxidoreductase) has not been established, but it has been suggested that it involves conformational changes. Here, the influence of substrates on the conformation of purified complex I from Escherichia coli was studied by cross-linking and electron microscopy. When a zero-length cross-linking reagent was used, the presence of NAD(P)H, in contrast to that of NAD+, prevented the formation of cross-links between the hydrophilic subunits of the complex, including NuoB, NuoI, and NuoCD. Comparisons using different cross-linkers suggested that NuoB, which is likely to coordinate the key iron-sulfur cluster N2, is the most mobile subunit. The presence of NAD(P)H led also to enhanced proteolysis of subunit NuoG. These data indicate that upon NAD(P)H binding, the peripheral arm of the complex adopts a more open conformation, with increased distances between subunits. Single particle analysis showed the nature of this conformational change. The enzyme retains its L-shape in the presence of NADH, but exhibits a significantly more open or expanded structure both in the peripheral arm and, unexpectedly, in the membrane domain also. acknowledgement: This work was supported by the Medical Research Council and by a Royal Society/North Atlantic Treaty Organization postdoctoral fellowship (to A. A. M.) author: - first_name: Aygun full_name: Mamedova, Aygun A last_name: Mamedova - first_name: Peter full_name: Holt, Peter J last_name: Holt - first_name: Joe full_name: Carroll, Joe D last_name: Carroll - first_name: Leonid A full_name: Leonid Sazanov id: 338D39FE-F248-11E8-B48F-1D18A9856A87 last_name: Sazanov orcid: 0000-0002-0977-7989 citation: ama: Mamedova A, Holt P, Carroll J, Sazanov LA. Substrate-induced conformational change in bacterial complex I. Journal of Biological Chemistry. 2004;279(22):23830-23836. doi:10.1074/jbc.M401539200 apa: Mamedova, A., Holt, P., Carroll, J., & Sazanov, L. A. (2004). Substrate-induced conformational change in bacterial complex I. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M401539200 chicago: Mamedova, Aygun, Peter Holt, Joe Carroll, and Leonid A Sazanov. “Substrate-Induced Conformational Change in Bacterial Complex I.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2004. https://doi.org/10.1074/jbc.M401539200. ieee: A. Mamedova, P. Holt, J. Carroll, and L. A. Sazanov, “Substrate-induced conformational change in bacterial complex I,” Journal of Biological Chemistry, vol. 279, no. 22. American Society for Biochemistry and Molecular Biology, pp. 23830–23836, 2004. ista: Mamedova A, Holt P, Carroll J, Sazanov LA. 2004. Substrate-induced conformational change in bacterial complex I. Journal of Biological Chemistry. 279(22), 23830–23836. mla: Mamedova, Aygun, et al. “Substrate-Induced Conformational Change in Bacterial Complex I.” Journal of Biological Chemistry, vol. 279, no. 22, American Society for Biochemistry and Molecular Biology, 2004, pp. 23830–36, doi:10.1074/jbc.M401539200. short: A. Mamedova, P. Holt, J. Carroll, L.A. Sazanov, Journal of Biological Chemistry 279 (2004) 23830–23836. date_created: 2018-12-11T11:54:56Z date_published: 2004-05-28T00:00:00Z date_updated: 2021-01-12T06:54:22Z day: '28' doi: 10.1074/jbc.M401539200 extern: 1 intvolume: ' 279' issue: '22' month: '05' page: 23830 - 23836 publication: Journal of Biological Chemistry publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '5123' quality_controlled: 0 status: public title: Substrate-induced conformational change in bacterial complex I type: journal_article volume: 279 year: '2004' ... --- _id: '209' author: - first_name: Timothy D full_name: Timothy Browning id: 35827D50-F248-11E8-B48F-1D18A9856A87 last_name: Browning orcid: 0000-0002-8314-0177 - first_name: Roger full_name: Heath-Brown, Roger last_name: Heath Brown citation: ama: Browning TD, Heath Brown R. Equal sums of three powers. Inventiones Mathematicae. 2004;157(3):553-573. doi:10.1007/s00222-004-0360-9 apa: Browning, T. D., & Heath Brown, R. (2004). Equal sums of three powers. Inventiones Mathematicae. Unknown. https://doi.org/10.1007/s00222-004-0360-9 chicago: Browning, Timothy D, and Roger Heath Brown. “Equal Sums of Three Powers.” Inventiones Mathematicae. Unknown, 2004. https://doi.org/10.1007/s00222-004-0360-9. ieee: T. D. Browning and R. Heath Brown, “Equal sums of three powers,” Inventiones Mathematicae, vol. 157, no. 3. Unknown, pp. 553–573, 2004. ista: Browning TD, Heath Brown R. 2004. Equal sums of three powers. Inventiones Mathematicae. 157(3), 553–573. mla: Browning, Timothy D., and Roger Heath Brown. “Equal Sums of Three Powers.” Inventiones Mathematicae, vol. 157, no. 3, Unknown, 2004, pp. 553–73, doi:10.1007/s00222-004-0360-9. short: T.D. Browning, R. Heath Brown, Inventiones Mathematicae 157 (2004) 553–573. date_created: 2018-12-11T11:45:13Z date_published: 2004-03-17T00:00:00Z date_updated: 2021-01-12T06:55:14Z day: '17' doi: 10.1007/s00222-004-0360-9 extern: 1 intvolume: ' 157' issue: '3' month: '03' page: 553 - 573 publication: Inventiones Mathematicae publication_status: published publisher: Unknown publist_id: '7703' quality_controlled: 0 status: public title: Equal sums of three powers type: journal_article volume: 157 year: '2004' ... --- _id: '2308' abstract: - lang: eng text: It is widely believed that the inflammatory events mediated by microglial activation contribute to several neurodegenerative processes. Alzheimer's disease, for example, is characterized by an accumulation of β-amyloid protein (Aβ) in neuritic plaques that are infiltrated by reactive microglia and astrocytes. Although Aβ and its fragment 25-35 exert a direct toxic effect on neurons, they also activate microglia. Microglial activation is accompanied by morphological changes, cell proliferation, and release of various cytokines and growth factors. A number of scientific reports suggest that the increased proliferation of microglial cells is dependent on ionic membrane currents and in particular on chloride conductances. An unusual chloride ion channel known to be associated with macrophage activation is the chloride intracellular channel-1 (CLIC1). Here we show that Aβ stimulation of neonatal rat microglia specifically leads to the increase in CLIC1 protein and to the functional expression of CLIC1 chloride conductance, both barely detectable on the plasma membrane of quiescent cells. CLIC1 protein expression in microglia increases after 24 hr of incubation with Aβ, simultaneously with the production of reactive nitrogen intermediates and of tumor necrosis factor-α (TNF-α). We demonstrate that reducing CLIC1 chloride conductance by a specific blocker [IAA-94 (R(+)-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5yl)-oxy] acetic acid)] prevents neuronal apoptosis in neurons cocultured with Aβ-treated microglia. Furthermore, we show that small interfering RNAs used to knock down CLIC1 expression prevent TNF-α release induced by Aβ stimulation. These results provide a direct link between Aβ-induced microglial activation and CLIC1 functional expression. author: - first_name: Gaia full_name: Gaia Novarino id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Cinzia full_name: Fabrizi, Cinzia last_name: Fabrizi - first_name: Raffaella full_name: Tonini, Raffaella last_name: Tonini - first_name: Michela full_name: Denti, Michela A last_name: Denti - first_name: Albedi full_name: Malchiodi, Albedi F last_name: Malchiodi - first_name: Giuliana full_name: Lauro, Giuliana M last_name: Lauro - first_name: Benedetto full_name: Sacchetti, Benedetto last_name: Sacchetti - first_name: Silvia full_name: Paradisi, Silvia last_name: Paradisi - first_name: Arnaldo full_name: Ferroni, Arnaldo last_name: Ferroni - first_name: Paul full_name: Curmi, Paul M G last_name: Curmi - first_name: Samuel full_name: Breit, Samuel N last_name: Breit - first_name: Michele full_name: Mazzanti, Michele last_name: Mazzanti citation: ama: Novarino G, Fabrizi C, Tonini R, et al. Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. Journal of Neuroscience. 2004;24(23):5322-5330. doi:10.1523/JNEUROSCI.1170-04.2004 apa: Novarino, G., Fabrizi, C., Tonini, R., Denti, M., Malchiodi, A., Lauro, G., … Mazzanti, M. (2004). Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1170-04.2004 chicago: Novarino, Gaia, Cinzia Fabrizi, Raffaella Tonini, Michela Denti, Albedi Malchiodi, Giuliana Lauro, Benedetto Sacchetti, et al. “Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated β-Amyloid-Induced Neurotoxicity.” Journal of Neuroscience. Society for Neuroscience, 2004. https://doi.org/10.1523/JNEUROSCI.1170-04.2004. ieee: G. Novarino et al., “Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity,” Journal of Neuroscience, vol. 24, no. 23. Society for Neuroscience, pp. 5322–5330, 2004. ista: Novarino G, Fabrizi C, Tonini R, Denti M, Malchiodi A, Lauro G, Sacchetti B, Paradisi S, Ferroni A, Curmi P, Breit S, Mazzanti M. 2004. Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. Journal of Neuroscience. 24(23), 5322–5330. mla: Novarino, Gaia, et al. “Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated β-Amyloid-Induced Neurotoxicity.” Journal of Neuroscience, vol. 24, no. 23, Society for Neuroscience, 2004, pp. 5322–30, doi:10.1523/JNEUROSCI.1170-04.2004. short: G. Novarino, C. Fabrizi, R. Tonini, M. Denti, A. Malchiodi, G. Lauro, B. Sacchetti, S. Paradisi, A. Ferroni, P. Curmi, S. Breit, M. Mazzanti, Journal of Neuroscience 24 (2004) 5322–5330. date_created: 2018-12-11T11:56:54Z date_published: 2004-06-09T00:00:00Z date_updated: 2021-01-12T06:56:41Z day: '09' doi: 10.1523/JNEUROSCI.1170-04.2004 extern: 1 intvolume: ' 24' issue: '23' month: '06' page: 5322 - 5330 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '4620' quality_controlled: 0 status: public title: Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity type: journal_article volume: 24 year: '2004' ... --- _id: '2356' abstract: - lang: eng text: 'Recent experimental and theoretical work has shown that there are conditions in which a trapped, low-density Bose gas behaves like the one-dimensional delta-function Bose gas solved years ago by Lieb and Liniger. This is an intrinsically quantum-mechanical phenomenon because it is not necessary to have a trap width that is the size of an atom - as might have been supposed - but it suffices merely to have a trap width such that the energy gap for motion in the transverse direction is large compared to the energy associated with the motion along the trap. Up to now the theoretical arguments have been based on variational - perturbative ideas or numerical investigations. In contrast, this paper gives a rigorous proof of the one-dimensional behavior as far as the ground state energy and particle density are concerned. There are four parameters involved: the particle number, N, transverse and longitudinal dimensions of the trap, r and L, and the scattering length a of the interaction potential. Our main result is that if r/L → 0 and N → ∞ the ground state energy and density can be obtained by minimizing a one-dimensional density functional involving the Lieb-Liniger energy density with coupling constant ∼ a/r 2. This density functional simplifies in various limiting cases and we identify five asymptotic parameter regions altogether. Three of these, corresponding to the weak coupling regime, can also be obtained as limits of a three-dimensional Gross-Pitaevskii theory. We also show that Bose-Einstein condensation in the ground state persists in a part of this regime. In the strong coupling regime the longitudinal motion of the particles is strongly correlated. The Gross-Pitaevskii description is not valid in this regime and new mathematical methods come into play.' author: - first_name: Élliott full_name: Lieb, Élliott H last_name: Lieb - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: Lieb É, Seiringer R, Yngvason J. One-dimensional behavior of dilute, trapped Bose gases. Communications in Mathematical Physics. 2004;244(2):347-393. doi:10.1007/s00220-003-0993-3 apa: Lieb, É., Seiringer, R., & Yngvason, J. (2004). One-dimensional behavior of dilute, trapped Bose gases. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s00220-003-0993-3 chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “One-Dimensional Behavior of Dilute, Trapped Bose Gases.” Communications in Mathematical Physics. Springer, 2004. https://doi.org/10.1007/s00220-003-0993-3. ieee: É. Lieb, R. Seiringer, and J. Yngvason, “One-dimensional behavior of dilute, trapped Bose gases,” Communications in Mathematical Physics, vol. 244, no. 2. Springer, pp. 347–393, 2004. ista: Lieb É, Seiringer R, Yngvason J. 2004. One-dimensional behavior of dilute, trapped Bose gases. Communications in Mathematical Physics. 244(2), 347–393. mla: Lieb, Élliott, et al. “One-Dimensional Behavior of Dilute, Trapped Bose Gases.” Communications in Mathematical Physics, vol. 244, no. 2, Springer, 2004, pp. 347–93, doi:10.1007/s00220-003-0993-3. short: É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics 244 (2004) 347–393. date_created: 2018-12-11T11:57:11Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T06:56:59Z day: '01' doi: 10.1007/s00220-003-0993-3 extern: 1 intvolume: ' 244' issue: '2' main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0305025 month: '01' oa: 1 page: 347 - 393 publication: Communications in Mathematical Physics publication_status: published publisher: Springer publist_id: '4569' quality_controlled: 0 status: public title: One-dimensional behavior of dilute, trapped Bose gases type: journal_article volume: 244 year: '2004' ... --- _id: '2355' abstract: - lang: eng text: 'The BMV conjecture for traces, which states that Tr exp(A - λB) is the Laplace transform of a positive measure, is shown to be equivalent to two other statements: (i) The polynomial λ → Tr(A + λB) p has only non-negative coefficients for all A, B ≥ 0, p ∈ ℕ and (ii) λ → Tr(A + λB)-p is the Laplace transform of a positive measure for A, B ≥ 0, p > 0.' author: - first_name: Élliott full_name: Lieb, Élliott H last_name: Lieb - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Lieb É, Seiringer R. Equivalent forms of the Bessis-Moussa-Villani conjecture. Journal of Statistical Physics. 2004;115(1-2):185-190. doi:10.1023/B:JOSS.0000019811.15510.27 apa: Lieb, É., & Seiringer, R. (2004). Equivalent forms of the Bessis-Moussa-Villani conjecture. Journal of Statistical Physics. Springer. https://doi.org/10.1023/B:JOSS.0000019811.15510.27 chicago: Lieb, Élliott, and Robert Seiringer. “ Equivalent Forms of the Bessis-Moussa-Villani Conjecture.” Journal of Statistical Physics. Springer, 2004. https://doi.org/10.1023/B:JOSS.0000019811.15510.27. ieee: É. Lieb and R. Seiringer, “ Equivalent forms of the Bessis-Moussa-Villani conjecture,” Journal of Statistical Physics, vol. 115, no. 1–2. Springer, pp. 185–190, 2004. ista: Lieb É, Seiringer R. 2004. Equivalent forms of the Bessis-Moussa-Villani conjecture. Journal of Statistical Physics. 115(1–2), 185–190. mla: Lieb, Élliott, and Robert Seiringer. “ Equivalent Forms of the Bessis-Moussa-Villani Conjecture.” Journal of Statistical Physics, vol. 115, no. 1–2, Springer, 2004, pp. 185–90, doi:10.1023/B:JOSS.0000019811.15510.27. short: É. Lieb, R. Seiringer, Journal of Statistical Physics 115 (2004) 185–190. date_created: 2018-12-11T11:57:11Z date_published: 2004-04-01T00:00:00Z date_updated: 2021-01-12T06:56:59Z day: '01' doi: 10.1023/B:JOSS.0000019811.15510.27 extern: 1 intvolume: ' 115' issue: 1-2 main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0210027 month: '04' oa: 1 page: 185 - 190 publication: Journal of Statistical Physics publication_status: published publisher: Springer publist_id: '4568' quality_controlled: 0 status: public title: ' Equivalent forms of the Bessis-Moussa-Villani conjecture' type: journal_article volume: 115 year: '2004' ... --- _id: '2360' abstract: - lang: eng text: An optical lattice model developed that is similar to the Bose-Hubbard model to describe the transition between Bose-Einstein condensation (BEC) and a Mott insulator state was analyzed. It was found that the system was a hard core lattice gas at half of the maximum density and the optical lattice was modeled by a periodic potential of strength λ. It was also observed that the interparticle interaction was essential for this transition that occurred even in the ground state. The results show that all the essential features could be proved rigorously such as the existence of BEC for small λ and its suppression for a large λ. author: - first_name: Michael full_name: Aizenman, Michael last_name: Aizenman - first_name: Élliott full_name: Lieb, Élliott H last_name: Lieb - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jan full_name: Solovej, Jan P last_name: Solovej - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: Aizenman M, Lieb É, Seiringer R, Solovej J, Yngvason J. Bose-Einstein quantum phase transition in an optical lattice model. Physical Review A - Atomic, Molecular, and Optical Physics. 2004;70(2):023612-1-0236121-2. doi:10.1103/PhysRevA.70.023612 apa: Aizenman, M., Lieb, É., Seiringer, R., Solovej, J., & Yngvason, J. (2004). Bose-Einstein quantum phase transition in an optical lattice model. Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.70.023612 chicago: Aizenman, Michael, Élliott Lieb, Robert Seiringer, Jan Solovej, and Jakob Yngvason. “Bose-Einstein Quantum Phase Transition in an Optical Lattice Model.” Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society, 2004. https://doi.org/10.1103/PhysRevA.70.023612. ieee: M. Aizenman, É. Lieb, R. Seiringer, J. Solovej, and J. Yngvason, “Bose-Einstein quantum phase transition in an optical lattice model,” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 70, no. 2. American Physical Society, pp. 023612-1-0236121-2, 2004. ista: Aizenman M, Lieb É, Seiringer R, Solovej J, Yngvason J. 2004. Bose-Einstein quantum phase transition in an optical lattice model. Physical Review A - Atomic, Molecular, and Optical Physics. 70(2), 023612-1-0236121-2. mla: Aizenman, Michael, et al. “Bose-Einstein Quantum Phase Transition in an Optical Lattice Model.” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 70, no. 2, American Physical Society, 2004, pp. 023612-1-0236121-2, doi:10.1103/PhysRevA.70.023612. short: M. Aizenman, É. Lieb, R. Seiringer, J. Solovej, J. Yngvason, Physical Review A - Atomic, Molecular, and Optical Physics 70 (2004) 023612-1-0236121-2. date_created: 2018-12-11T11:57:12Z date_published: 2004-08-01T00:00:00Z date_updated: 2021-01-12T06:57:01Z day: '01' doi: 10.1103/PhysRevA.70.023612 extern: 1 intvolume: ' 70' issue: '2' main_file_link: - open_access: '1' url: http://arxiv.org/abs/cond-mat/0403240 month: '08' oa: 1 page: 023612 - 1-0236121-2 publication: Physical Review A - Atomic, Molecular, and Optical Physics publication_status: published publisher: American Physical Society publist_id: '4567' quality_controlled: 0 status: public title: Bose-Einstein quantum phase transition in an optical lattice model type: journal_article volume: 70 year: '2004' ... --- _id: '2417' alternative_title: - 'Contemporary Mathematics ' author: - first_name: László full_name: Lovász, László last_name: Lovász - first_name: Katalin full_name: Vesztergombi, Katalin last_name: Vesztergombi - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 - first_name: Emo full_name: Welzl, Emo last_name: Welzl citation: ama: 'Lovász L, Vesztergombi K, Wagner U, Welzl E. Convex quadrilaterals and k-sets . In: Pach J, ed. Towards a Theory of Geometric Graphs. Vol 342. American Mathematical Society; 2004:139-148. doi:10.1090/conm/342' apa: Lovász, L., Vesztergombi, K., Wagner, U., & Welzl, E. (2004). Convex quadrilaterals and k-sets . In J. Pach (Ed.), Towards a Theory of Geometric Graphs (Vol. 342, pp. 139–148). American Mathematical Society. https://doi.org/10.1090/conm/342 chicago: Lovász, László, Katalin Vesztergombi, Uli Wagner, and Emo Welzl. “Convex Quadrilaterals and K-Sets .” In Towards a Theory of Geometric Graphs, edited by János Pach, 342:139–48. American Mathematical Society, 2004. https://doi.org/10.1090/conm/342. ieee: L. Lovász, K. Vesztergombi, U. Wagner, and E. Welzl, “Convex quadrilaterals and k-sets ,” in Towards a Theory of Geometric Graphs, vol. 342, J. Pach, Ed. American Mathematical Society, 2004, pp. 139–148. ista: 'Lovász L, Vesztergombi K, Wagner U, Welzl E. 2004.Convex quadrilaterals and k-sets . In: Towards a Theory of Geometric Graphs. Contemporary Mathematics , vol. 342, 139–148.' mla: Lovász, László, et al. “Convex Quadrilaterals and K-Sets .” Towards a Theory of Geometric Graphs, edited by János Pach, vol. 342, American Mathematical Society, 2004, pp. 139–48, doi:10.1090/conm/342. short: L. Lovász, K. Vesztergombi, U. Wagner, E. Welzl, in:, J. Pach (Ed.), Towards a Theory of Geometric Graphs, American Mathematical Society, 2004, pp. 139–148. date_created: 2018-12-11T11:57:32Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T06:57:21Z day: '01' doi: 10.1090/conm/342 editor: - first_name: János full_name: Pach, János last_name: Pach extern: 1 intvolume: ' 342' month: '01' page: 139 - 148 publication: Towards a Theory of Geometric Graphs publication_status: published publisher: American Mathematical Society publist_id: '4508' quality_controlled: 0 status: public title: 'Convex quadrilaterals and k-sets ' type: book_chapter volume: 342 year: '2004' ... --- _id: '2426' abstract: - lang: eng text: We introduce the adaptive neighborhood graph as a data structure for modeling a smooth manifold M embedded in some Euclidean space ℝ d. We assume that M is known to us only through a finite sample P ⊂ M, as is often the case in applications. The adaptive neighborhood graph is a geometric graph on P. Its complexity is at most min{2O(k)n, n2}, where n = P and k = dim M, as opposed to the n[d/2] complexity of the Delaunay triangulation, which is often used to model manifolds. We prove that we can correctly infer the connected components and the dimension of M from the adaptive neighborhood graph provided a certain standard sampling condition is fulfilled. The running time of the dimension detection algorithm is d20(k7 log k) for each connected component of M. If the dimension is considered constant, this is a constant-time operation, and the adaptive neighborhood graph is of linear size. Moreover, the exponential dependence of the constants is only on the intrinsic dimension k, not on the ambient dimension d. This is of particular interest if the co-dimension is high, i.e., if k is much smaller than d, as is the case in many applications. The adaptive neighborhood graph also allows us to approximate the geodesic distances between the points in P. author: - first_name: Joachim full_name: Giesen, Joachim last_name: Giesen - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: Giesen J, Wagner U. Shape dimension and intrinsic metric from samples of manifolds. Discrete & Computational Geometry. 2004;32(2):245-267. doi:10.1007/s00454-004-1120-8 apa: Giesen, J., & Wagner, U. (2004). Shape dimension and intrinsic metric from samples of manifolds. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-004-1120-8 chicago: Giesen, Joachim, and Uli Wagner. “Shape Dimension and Intrinsic Metric from Samples of Manifolds.” Discrete & Computational Geometry. Springer, 2004. https://doi.org/10.1007/s00454-004-1120-8. ieee: J. Giesen and U. Wagner, “Shape dimension and intrinsic metric from samples of manifolds,” Discrete & Computational Geometry, vol. 32, no. 2. Springer, pp. 245–267, 2004. ista: Giesen J, Wagner U. 2004. Shape dimension and intrinsic metric from samples of manifolds. Discrete & Computational Geometry. 32(2), 245–267. mla: Giesen, Joachim, and Uli Wagner. “Shape Dimension and Intrinsic Metric from Samples of Manifolds.” Discrete & Computational Geometry, vol. 32, no. 2, Springer, 2004, pp. 245–67, doi:10.1007/s00454-004-1120-8. short: J. Giesen, U. Wagner, Discrete & Computational Geometry 32 (2004) 245–267. date_created: 2018-12-11T11:57:35Z date_published: 2004-09-01T00:00:00Z date_updated: 2021-01-12T06:57:25Z day: '01' doi: 10.1007/s00454-004-1120-8 extern: 1 intvolume: ' 32' issue: '2' month: '09' page: 245 - 267 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '4499' quality_controlled: 0 status: public title: Shape dimension and intrinsic metric from samples of manifolds type: journal_article volume: 32 year: '2004' ... --- _id: '2425' abstract: - lang: eng text: A finite set N ⊂ Rd is a weak ε-net for an n-point set X ⊂ Rd (with respect to convex sets) if N intersects every convex set K with |K ∩ X| ≥ εn. We give an alternative, and arguably simpler, proof of the fact, first shown by Chazelle et al., that every point set X in Rd admits a weak ε-net of cardinality O(ε-dpolylog(1/ε)). Moreover, for a number of special point sets (e.g., for points on the moment curve), our method gives substantially better bounds. The construction yields an algorithm to construct such weak ε-nets in time O(n ln(1/ε)). author: - first_name: Jiří full_name: Matoušek, Jiří last_name: Matoušek - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: Matoušek J, Wagner U. New constructions of weak ε-nets. Discrete & Computational Geometry. 2004;32(2):195-206. doi:10.1007/s00454-004-1116-4 apa: Matoušek, J., & Wagner, U. (2004). New constructions of weak ε-nets. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-004-1116-4 chicago: Matoušek, Jiří, and Uli Wagner. “New Constructions of Weak ε-Nets.” Discrete & Computational Geometry. Springer, 2004. https://doi.org/10.1007/s00454-004-1116-4. ieee: J. Matoušek and U. Wagner, “New constructions of weak ε-nets,” Discrete & Computational Geometry, vol. 32, no. 2. Springer, pp. 195–206, 2004. ista: Matoušek J, Wagner U. 2004. New constructions of weak ε-nets. Discrete & Computational Geometry. 32(2), 195–206. mla: Matoušek, Jiří, and Uli Wagner. “New Constructions of Weak ε-Nets.” Discrete & Computational Geometry, vol. 32, no. 2, Springer, 2004, pp. 195–206, doi:10.1007/s00454-004-1116-4. short: J. Matoušek, U. Wagner, Discrete & Computational Geometry 32 (2004) 195–206. date_created: 2018-12-11T11:57:35Z date_published: 2004-07-01T00:00:00Z date_updated: 2021-01-12T06:57:24Z day: '01' doi: 10.1007/s00454-004-1116-4 extern: 1 intvolume: ' 32' issue: '2' month: '07' page: 195 - 206 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '4500' quality_controlled: 0 status: public title: New constructions of weak ε-nets type: journal_article volume: 32 year: '2004' ... --- _id: '2461' author: - first_name: Michael full_name: Sauer, Michael last_name: Sauer - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Sauer M, Friml J. The Matryoshka dolls of plant polarity. Development. 2004;131(23):5774-5775. doi:10.1242/dev.01463 apa: Sauer, M., & Friml, J. (2004). The Matryoshka dolls of plant polarity. Development. Company of Biologists. https://doi.org/10.1242/dev.01463 chicago: Sauer, Michael, and Jiří Friml. “The Matryoshka Dolls of Plant Polarity.” Development. Company of Biologists, 2004. https://doi.org/10.1242/dev.01463. ieee: M. Sauer and J. Friml, “The Matryoshka dolls of plant polarity,” Development, vol. 131, no. 23. Company of Biologists, pp. 5774–5775, 2004. ista: Sauer M, Friml J. 2004. The Matryoshka dolls of plant polarity. Development. 131(23), 5774–5775. mla: Sauer, Michael, and Jiří Friml. “The Matryoshka Dolls of Plant Polarity.” Development, vol. 131, no. 23, Company of Biologists, 2004, pp. 5774–75, doi:10.1242/dev.01463. short: M. Sauer, J. Friml, Development 131 (2004) 5774–5775. date_created: 2018-12-11T11:57:48Z date_published: 2004-12-01T00:00:00Z date_updated: 2021-01-12T06:57:37Z day: '01' doi: 10.1242/dev.01463 extern: '1' intvolume: ' 131' issue: '23' language: - iso: eng month: '12' oa_version: None page: 5774 - 5775 publication: Development publication_status: published publisher: Company of Biologists publist_id: '4442' quality_controlled: '1' status: public title: The Matryoshka dolls of plant polarity type: review user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 131 year: '2004' ... --- _id: '2642' abstract: - lang: eng text: In the hippocampal CA1 region, metabotropic glutamate subtype 1 (mGluR1) receptors have been implicated in a variety of physiological responses to glutamate, which include modulation of synaptic transmission and plasticity, as well as neuronal excitability and synchronization. The mGluR1α isoform is characteristically expressed only by nonprincipal cells, and it is particularly enriched in somatostatin (SS -containing interneurons in stratum oriens-alveus. Anatomical and physiological data have indicated the presence of mGluR1α in several distinct classes of interneurons with their somata located also in strata pyramidale, radiatum, and lacunosum moleculare. Each different interneuron subtype, as defined by functionally relevant criteria, including input/output characteristics and expression of selective molecular markers, subserves distinct functions in local hippocampal circuits. We have investigated which of the different CA1 interneuron classes express mGluR1α by immunofluorescent labeling, combining antibodies to mGluR1α, calcium-binding proteins, and neuropeptides, and by intracellular labeling in vitro. Several types of interneuron that are immunopositive for mGluR1α each targeted different domains of pyramidal cells and included (1) O-LM interneurons, found to coexpress both SS and parvalbumin (PV); (2) interneurons with target selectivity for other interneurons, expressing vasoactive intestinal polypeptide (VIP) and/or the calcium-binding protein calretinin; (3) procholecystokinin-immunopositive interneurons probably non-basket and dendrite-targeting; and (4) an as-yet unidentified SS-immunoreactive but PV-immunonegative interneuron class, possibly corresponding to oriensbistratified cells. Estimation of the relative proportion of mGluR1α-positive interneurons showed 43%, 46%, and 30% co-labeling with SS, VIP, or PV, respectively. The identification of the specific subclasses of CA1 interneurons expressing mGluR1α provides the network basis for assessing the contribution of this receptor to the excitability of the hippocampus. author: - first_name: Francesco full_name: Ferraguti, Francesco last_name: Ferraguti - first_name: Philip full_name: Cobden, Philip M last_name: Cobden - first_name: Marie full_name: Pollard, Marie last_name: Pollard - first_name: David full_name: Cope, David W last_name: Cope - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Masahiko full_name: Watanabe, Masahiko last_name: Watanabe - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi citation: ama: Ferraguti F, Cobden P, Pollard M, et al. Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus. 2004;14(2):193-215. doi:10.1002/hipo.10163 apa: Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., & Somogyi, P. (2004). Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus. Wiley-Blackwell. https://doi.org/10.1002/hipo.10163 chicago: Ferraguti, Francesco, Philip Cobden, Marie Pollard, David Cope, Ryuichi Shigemoto, Masahiko Watanabe, and Péter Somogyi. “Immunolocalization of Metabotropic Glutamate Receptor 1α (MGluR1α) in Distinct Classes of Interneuron in the CA1 Region of the Rat Hippocampus.” Hippocampus. Wiley-Blackwell, 2004. https://doi.org/10.1002/hipo.10163. ieee: F. Ferraguti et al., “Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus,” Hippocampus, vol. 14, no. 2. Wiley-Blackwell, pp. 193–215, 2004. ista: Ferraguti F, Cobden P, Pollard M, Cope D, Shigemoto R, Watanabe M, Somogyi P. 2004. Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus. 14(2), 193–215. mla: Ferraguti, Francesco, et al. “Immunolocalization of Metabotropic Glutamate Receptor 1α (MGluR1α) in Distinct Classes of Interneuron in the CA1 Region of the Rat Hippocampus.” Hippocampus, vol. 14, no. 2, Wiley-Blackwell, 2004, pp. 193–215, doi:10.1002/hipo.10163. short: F. Ferraguti, P. Cobden, M. Pollard, D. Cope, R. Shigemoto, M. Watanabe, P. Somogyi, Hippocampus 14 (2004) 193–215. date_created: 2018-12-11T11:58:50Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T06:58:46Z day: '01' doi: 10.1002/hipo.10163 extern: 1 intvolume: ' 14' issue: '2' month: '01' page: 193 - 215 publication: Hippocampus publication_status: published publisher: Wiley-Blackwell publist_id: '4256' quality_controlled: 0 status: public title: Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus type: journal_article volume: 14 year: '2004' ... --- _id: '2639' abstract: - lang: eng text: Vesicular glutamate transporter type 3 (VGLUT3) containing neuronal elements were characterized using antibodies to VGLUT3 and molecular cell markers. All VGLUT3-positive somata were immunoreactive for CCK, and very rarely, also for calbindin; none was positive for parvalbumin, calretinin, VIP or somatostatin. In the CA1 area, 26.8 ± 0.7% of CCK-positive interneuron somata were VGLUT3-positive, a nonoverlapping 22.8 ± 1.9% were calbindin-positive, 10.7 ± 2.5% VIP-positive and the rest were only CCK-positive. The patterns of coexpression were similar in the CA3 area, the dentate gyrus and the isocortex. Immunoreactivity for VGLUT3 was undetectable in pyramidal and dentate granule cells. Boutons colabelled for VGLUT3, CCK and GAD were most abundant in the cellular layers of the hippocampus and in layers II-III of the isocortex. Large VGLUT3-labelled boutons at the border of strata radiatum and lacunosum-moleculare in the CA1 area were negative for GAD, but were labelled for vesicular monoamine transporter type 2, plasmalemmal serotonin transporter or serotonin. No colocalization was found in terminals between VGLUT3 and parvalbumin, vesicular acetylcholine transporter and group III (mGluR7a,b; mGluR8a,b) metabotropic glutamate receptors. In stratum radiatum and the isocortex, VGLUT3-positive but GAD-negative boutons heavily innervated the soma and proximal dendrites of some VGLUT3- or calbindin-positive interneurons. The results suggest that boutons coexpressing VGLUT3, CCK and GAD originate from CCK-positive basket cells, which are VIP-immunonegative. Other VGLUT3-positive boutons immunopositive for serotonergic markers but negative for GAD probably originate from the median raphe nucleus and innervate select interneurons. The presumed amino acid substrate of VGLUT3 may act on presynaptic kainate or group II metabotropic glutamate receptors. author: - first_name: Jozsef full_name: Somogyi, Jozsef last_name: Somogyi - first_name: Agnès full_name: Baude, Agnès last_name: Baude - first_name: Yuko full_name: Omori, Yuko last_name: Omori - first_name: Hidemi full_name: Shimizu, Hidemi last_name: Shimizu - first_name: Salah full_name: El-Mestikawy, Salah last_name: El Mestikawy - first_name: Masahiro full_name: Fukaya, Masahiro last_name: Fukaya - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Masahiko full_name: Watanabe, Masahiko last_name: Watanabe - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi citation: ama: Somogyi J, Baude A, Omori Y, et al. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. European Journal of Neuroscience. 2004;19(3):552-569. doi:10.1111/j.0953-816X.2003.03091.x apa: Somogyi, J., Baude, A., Omori, Y., Shimizu, H., El Mestikawy, S., Fukaya, M., … Somogyi, P. (2004). GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.0953-816X.2003.03091.x chicago: Somogyi, Jozsef, Agnès Baude, Yuko Omori, Hidemi Shimizu, Salah El Mestikawy, Masahiro Fukaya, Ryuichi Shigemoto, Masahiko Watanabe, and Péter Somogyi. “GABAergic Basket Cells Expressing Cholecystokinin Contain Vesicular Glutamate Transporter Type 3 (VGLUT3) in Their Synaptic Terminals in Hippocampus and Isocortex of the Rat.” European Journal of Neuroscience. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.0953-816X.2003.03091.x. ieee: J. Somogyi et al., “GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat,” European Journal of Neuroscience, vol. 19, no. 3. Wiley-Blackwell, pp. 552–569, 2004. ista: Somogyi J, Baude A, Omori Y, Shimizu H, El Mestikawy S, Fukaya M, Shigemoto R, Watanabe M, Somogyi P. 2004. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. European Journal of Neuroscience. 19(3), 552–569. mla: Somogyi, Jozsef, et al. “GABAergic Basket Cells Expressing Cholecystokinin Contain Vesicular Glutamate Transporter Type 3 (VGLUT3) in Their Synaptic Terminals in Hippocampus and Isocortex of the Rat.” European Journal of Neuroscience, vol. 19, no. 3, Wiley-Blackwell, 2004, pp. 552–69, doi:10.1111/j.0953-816X.2003.03091.x. short: J. Somogyi, A. Baude, Y. Omori, H. Shimizu, S. El Mestikawy, M. Fukaya, R. Shigemoto, M. Watanabe, P. Somogyi, European Journal of Neuroscience 19 (2004) 552–569. date_created: 2018-12-11T11:58:49Z date_published: 2004-02-01T00:00:00Z date_updated: 2021-01-12T06:58:44Z day: '01' doi: 10.1111/j.0953-816X.2003.03091.x extern: 1 intvolume: ' 19' issue: '3' month: '02' page: 552 - 569 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4260' quality_controlled: 0 status: public title: GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat type: journal_article volume: 19 year: '2004' ... --- _id: '2643' abstract: - lang: eng text: Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in pre- and postsynaptic inhibitory effects upon auditory neurons and have been implicated in different aspects of acoustic information processing. To understand better the mechanisms by which GABAB receptors mediate their inhibitory effects, we used pre-embedding immunocytochemical techniques combined with quantification of immunogold particles to reveal the precise subcellular distribution of the GABAB1 subunit in the rat dorsal cochlear nucleus. At the light microscopic level, GABAB1 was detected in all divisions of the cochlear complex. The most intense immunoreactivity for GABAB1 was found in the dorsal cochlear nucleus, whereas immunoreactivity in the anteroventral and posteroventral cochlear nuclei was very low. In the dorsal cochlear nucleus, a punctate labeling was observed in the superficial (molecular and fusiform cell) layers. At the electron microscopic level, GABAB1 was found at both post- and presynaptic locations. Postsynaptically, GABAB1 was localized mainly in the dendritic spines of presumed fusiform cells. Quantitative immunogold immunocytochemistry revealed that the highest concentration of GABA B1 in the plasma membrane was in dendritic spines, followed by dendritic shafts and somata. Thus, the most intense immunoreactivity for GABAB1 was observed in dendritic spines with a high density of immunogold particles at extrasynaptic sites, peaking around 300 nm from glutamatergic synapses. This is in contrast to GABAergic synapses, in which GABAB1 was only occasionally found. Presynaptically, receptor immunoreactivity was detected primarily in axospinous endings, probably from granule cells, in both the active zone and extrasynaptic sites. The localization of GABAB1 relative to synaptic sites in the DCN suggests a role for the receptor in the regulation of dendritic excitability and excitatory inputs. author: - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: José full_name: Juíz, José M last_name: Juíz citation: ama: Luján R, Shigemoto R, Kulik Á, Juíz J. Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. Journal of Comparative Neurology. 2004;475(1):36-46. doi:10.1002/cne.20160 apa: Luján, R., Shigemoto, R., Kulik, Á., & Juíz, J. (2004). Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.20160 chicago: Luján, Rafael, Ryuichi Shigemoto, Ákos Kulik, and José Juíz. “Localization of the GABAB Receptor 1a/b Subunit Relative to Glutamatergic Synapses in the Dorsal Cochlear Nucleus of the Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 2004. https://doi.org/10.1002/cne.20160. ieee: R. Luján, R. Shigemoto, Á. Kulik, and J. Juíz, “Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat,” Journal of Comparative Neurology, vol. 475, no. 1. Wiley-Blackwell, pp. 36–46, 2004. ista: Luján R, Shigemoto R, Kulik Á, Juíz J. 2004. Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. Journal of Comparative Neurology. 475(1), 36–46. mla: Luján, Rafael, et al. “Localization of the GABAB Receptor 1a/b Subunit Relative to Glutamatergic Synapses in the Dorsal Cochlear Nucleus of the Rat.” Journal of Comparative Neurology, vol. 475, no. 1, Wiley-Blackwell, 2004, pp. 36–46, doi:10.1002/cne.20160. short: R. Luján, R. Shigemoto, Á. Kulik, J. Juíz, Journal of Comparative Neurology 475 (2004) 36–46. date_created: 2018-12-11T11:58:50Z date_published: 2004-07-12T00:00:00Z date_updated: 2021-01-12T06:58:46Z day: '12' doi: 10.1002/cne.20160 extern: 1 intvolume: ' 475' issue: '1' month: '07' page: 36 - 46 publication: Journal of Comparative Neurology publication_status: published publisher: Wiley-Blackwell publist_id: '4254' quality_controlled: 0 status: public title: Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat type: journal_article volume: 475 year: '2004' ... --- _id: '2638' abstract: - lang: eng text: Among various types of low- and high-threshold calcium channels, the high voltage-activated P/Q-type channel is the most abundant in the cerebellum. These P/Q-type channels are involved in the regulation of neurotransmitter release and in the integration of dendritic inputs. We used an antibody specific for the α1A subunit of the P/Q-type channel in quantitative pre-embedding immunogold labelling combined with three-dimensional reconstruction to reveal the subcellular distribution of pre- and postsynaptic P/Q-type channels in the rat cerebellum. At the light microscopic level, immunoreactivity for the α1A protein was prevalent in the molecular layer, whereas immunostaining was moderate in the somata of Purkinje cells and weak in the granule cell layer. At the electron microscopic level, the most intense Immunoreactivity for the α1A subunit was found in the presynaptic active zone of parallel fibre varicosities. The dendritic spines of Purkinje cells were also strongly labelled with the highest density of immunoparticles detected within 180 nm from the edge of the asymmetrical parallel fibre-Purkinje cell synapses. By contrast, the immunolabelling was sparse in climbing fibre varicosities and axon terminals of GABAergic cells, and weak and diffuse in dendritic shafts of Purkinje cells. The association of the α1A subunit with the glutamatergic parallel fibre-Purkinje cell synapses suggests that presynaptic channels have a major role in the mediation of excitatory neurotransmission, whereas postsynaptic channels are likely to be involved in depolarization-induced generation of local calcium transients in Purkinje cells. author: - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: Kazuhiko full_name: Nakadate, Kazuhiko last_name: Nakadate - first_name: Akari full_name: Hagiwara, Akari last_name: Hagiwara - first_name: Yugo full_name: Fukazawa, Yugo last_name: Fukazawa - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Hiromitsu full_name: Saito, Hiromitsu last_name: Saito - first_name: Noboru full_name: Suzuki, Noboru last_name: Suzuki - first_name: Akira full_name: Futatsugi, Akira last_name: Futatsugi - first_name: Katsuhiko full_name: Mikoshiba, Katsuhiko last_name: Mikoshiba - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Kulik Á, Nakadate K, Hagiwara A, et al. Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. European Journal of Neuroscience. 2004;19(8):2169-2178. doi:10.1111/j.0953-816X.2004.03319.x apa: Kulik, Á., Nakadate, K., Hagiwara, A., Fukazawa, Y., Luján, R., Saito, H., … Shigemoto, R. (2004). Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.0953-816X.2004.03319.x chicago: Kulik, Ákos, Kazuhiko Nakadate, Akari Hagiwara, Yugo Fukazawa, Rafael Luján, Hiromitsu Saito, Noboru Suzuki, et al. “Immunocytochemical Localization of the Α1A Subunit of the P/Q-Type Calcium Channel in the Rat Cerebellum.” European Journal of Neuroscience. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.0953-816X.2004.03319.x. ieee: Á. Kulik et al., “Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum,” European Journal of Neuroscience, vol. 19, no. 8. Wiley-Blackwell, pp. 2169–2178, 2004. ista: Kulik Á, Nakadate K, Hagiwara A, Fukazawa Y, Luján R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R. 2004. Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum. European Journal of Neuroscience. 19(8), 2169–2178. mla: Kulik, Ákos, et al. “Immunocytochemical Localization of the Α1A Subunit of the P/Q-Type Calcium Channel in the Rat Cerebellum.” European Journal of Neuroscience, vol. 19, no. 8, Wiley-Blackwell, 2004, pp. 2169–78, doi:10.1111/j.0953-816X.2004.03319.x. short: Á. Kulik, K. Nakadate, A. Hagiwara, Y. Fukazawa, R. Luján, H. Saito, N. Suzuki, A. Futatsugi, K. Mikoshiba, M. Frotscher, R. Shigemoto, European Journal of Neuroscience 19 (2004) 2169–2178. date_created: 2018-12-11T11:58:48Z date_published: 2004-04-01T00:00:00Z date_updated: 2021-01-12T06:58:44Z day: '01' doi: 10.1111/j.0953-816X.2004.03319.x extern: 1 intvolume: ' 19' issue: '8' month: '04' page: 2169 - 2178 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4259' quality_controlled: 0 status: public title: Immunocytochemical localization of the α1A subunit of the P/Q-type calcium channel in the rat cerebellum type: journal_article volume: 19 year: '2004' ... --- _id: '2640' abstract: - lang: eng text: Hyperpolarization-activated cation currents (Ih) contribute to various physiological properties and functions in the brain, including neuronal pacemaker activity, setting of resting membrane potential, and dendritic integration of synaptic input. Four subunits of the Hyperpolarization-activated and Cyclic-Nucleotide-gated nonselective cation channels (HCN1-4), which generate Ih, have been cloned recently. To better understand the functional diversity of Ih in the brain, we examined precise immunohistochemical localization of four HCNs in the rat brain. Immunoreactivity for HCN1 showed predominantly cortical distribution, being intense in the neocortex, hippocampus, superior colliculus, and cerebellum, whereas those for HCN3 and HCN4 exhibited subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively. Immunoreactivity for HCN2 had a widespread distribution throughout the brain. Double immunofluorescence revealed colocalization of immunoreactivity for HCN1 and HCN2 in distal dendrites of pyramidal cells in the hippocampus and neocortex. At the electron microscopic level, immunogold particles for HCN1 and HCN2 had similar distribution patterns along plasma membrane of dendritic shafts in layer I of the neocortex and stratum lacunosum moleculare of the hippocampal CA1 area, suggesting that these subunits could form heteromeric channels. Our results further indicate that HCNs are localized not only in somato-dendritic compartments but also in axonal compartments of neurons. Immunoreactivity for HCNs often occurred in preterminal rather than terminal portions of axons and in specific populations of myelinated axons. We also found HCN2-immunopositive oligodendrocytes including perineuronal oligodendrocytes throughout the brain. These results support previous electrophysiological findings and further suggest unexpected roles of Ih channels in the brain. author: - first_name: Takuya full_name: Notomi, Takuya last_name: Notomi - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Notomi T, Shigemoto R. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Journal of Comparative Neurology. 2004;471(3):241-276. doi:10.1002/cne.11039 apa: Notomi, T., & Shigemoto, R. (2004). Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.11039 chicago: Notomi, Takuya, and Ryuichi Shigemoto. “Immunohistochemical Localization of Ih Channel Subunits, HCN1-4, in the Rat Brain.” Journal of Comparative Neurology. Wiley-Blackwell, 2004. https://doi.org/10.1002/cne.11039. ieee: T. Notomi and R. Shigemoto, “Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain,” Journal of Comparative Neurology, vol. 471, no. 3. Wiley-Blackwell, pp. 241–276, 2004. ista: Notomi T, Shigemoto R. 2004. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Journal of Comparative Neurology. 471(3), 241–276. mla: Notomi, Takuya, and Ryuichi Shigemoto. “Immunohistochemical Localization of Ih Channel Subunits, HCN1-4, in the Rat Brain.” Journal of Comparative Neurology, vol. 471, no. 3, Wiley-Blackwell, 2004, pp. 241–76, doi:10.1002/cne.11039. short: T. Notomi, R. Shigemoto, Journal of Comparative Neurology 471 (2004) 241–276. date_created: 2018-12-11T11:58:49Z date_published: 2004-04-05T00:00:00Z date_updated: 2021-01-12T06:58:45Z day: '05' doi: 10.1002/cne.11039 extern: 1 intvolume: ' 471' issue: '3' month: '04' page: 241 - 276 publication: Journal of Comparative Neurology publication_status: published publisher: Wiley-Blackwell publist_id: '4258' quality_controlled: 0 status: public title: Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain type: journal_article volume: 471 year: '2004' ... --- _id: '2641' abstract: - lang: eng text: The Na+-K+ pump current (Ip) and the h-current (Ih) flowing through hyperpolarization-activated channels (h-channels) participate in generating the resting potential. These two currents are thought to be produced independently. We show here bidirectional interactions between Na+-K+ pumps and h-channels in mesencephalic trigeminal neurons. Activation of Ih leads to the generation of two types of ouabain-sensitive Ip with temporal profiles similar to those of instantaneous and slow components of I h, presumably reflecting Na+ transients in a restricted cellular space. Moreover, the Ip activated by instantaneous I h can facilitate the subsequent activation of slow Ih. Such counteractive and cooperative interactions were also disclosed by replacing extracellular Na+ with Li+, which is permeant through h-channels but does not stimulate the Na+-K+ pump as strongly as Na+ ions. These observations indicate that the interactions are bidirectional and mediated by Na+ ions. Also after substitution of extracellular Na+ with Li+, the tail Ih was reduced markedly despite an enhancement of Ih itself, attributable to a negative shift of the reversal potential for I h presumably caused by intracellular accumulation of Li+ ions. This suggests the presence of a microdomain where the interactions can take place. Thus, the bidirectional interactions between Na+-K + pumps and h-channels are likely to be mediated by Na+ microdomain. Consistent with these findings, hyperpolarization-activated and cyclic nucleotide-modulated subunits (HCN1/2) and the Na+-K + pump α3 isoform were colocalized in plasma membrane of mesencephalic trigeminal neurons having numerous spines. author: - first_name: Youngnam full_name: Kang, Youngnam last_name: Kang - first_name: Takuya full_name: Notomi, Takuya last_name: Notomi - first_name: Mitsuru full_name: Saito, Mitsuru last_name: Saito - first_name: Wei full_name: Zhang, Wei last_name: Zhang - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. 2004;24(14):3694-3702. doi:10.1523/JNEUROSCI.5641-03.2004 apa: Kang, Y., Notomi, T., Saito, M., Zhang, W., & Shigemoto, R. (2004). Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.5641-03.2004 chicago: Kang, Youngnam, Takuya Notomi, Mitsuru Saito, Wei Zhang, and Ryuichi Shigemoto. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” Journal of Neuroscience. Society for Neuroscience, 2004. https://doi.org/10.1523/JNEUROSCI.5641-03.2004. ieee: Y. Kang, T. Notomi, M. Saito, W. Zhang, and R. Shigemoto, “Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons,” Journal of Neuroscience, vol. 24, no. 14. Society for Neuroscience, pp. 3694–3702, 2004. ista: Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. 2004. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. 24(14), 3694–3702. mla: Kang, Youngnam, et al. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” Journal of Neuroscience, vol. 24, no. 14, Society for Neuroscience, 2004, pp. 3694–702, doi:10.1523/JNEUROSCI.5641-03.2004. short: Y. Kang, T. Notomi, M. Saito, W. Zhang, R. Shigemoto, Journal of Neuroscience 24 (2004) 3694–3702. date_created: 2018-12-11T11:58:49Z date_published: 2004-04-07T00:00:00Z date_updated: 2021-01-12T06:58:45Z day: '07' doi: 10.1523/JNEUROSCI.5641-03.2004 extern: 1 intvolume: ' 24' issue: '14' month: '04' page: 3694 - 3702 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '4257' quality_controlled: 0 status: public title: Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons type: journal_article volume: 24 year: '2004' ... --- _id: '2636' author: - first_name: Akiko full_name: Momiyama, Akiko last_name: Momiyama - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Momiyama A, Shigemoto R. Function and distribution of glutamate receptors in the central synapses. Tanpakushitsu kakusan koso Protein nucleic acid enzyme. 2004;49(3 Suppl):287-294. apa: Momiyama, A., & Shigemoto, R. (2004). Function and distribution of glutamate receptors in the central synapses. Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme. Kyoritsu Shuppan. chicago: Momiyama, Akiko, and Ryuichi Shigemoto. “Function and Distribution of Glutamate Receptors in the Central Synapses.” Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme. Kyoritsu Shuppan, 2004. ieee: A. Momiyama and R. Shigemoto, “Function and distribution of glutamate receptors in the central synapses,” Tanpakushitsu kakusan koso Protein nucleic acid enzyme, vol. 49, no. 3 Suppl. Kyoritsu Shuppan, pp. 287–294, 2004. ista: Momiyama A, Shigemoto R. 2004. Function and distribution of glutamate receptors in the central synapses. Tanpakushitsu kakusan koso Protein nucleic acid enzyme. 49(3 Suppl), 287–294. mla: Momiyama, Akiko, and Ryuichi Shigemoto. “Function and Distribution of Glutamate Receptors in the Central Synapses.” Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme, vol. 49, no. 3 Suppl, Kyoritsu Shuppan, 2004, pp. 287–94. short: A. Momiyama, R. Shigemoto, Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme 49 (2004) 287–294. date_created: 2018-12-11T11:58:48Z date_published: 2004-02-01T00:00:00Z date_updated: 2020-07-14T12:45:44Z day: '01' extern: 1 intvolume: ' 49' issue: 3 Suppl month: '02' page: 287 - 294 publication: Tanpakushitsu kakusan koso Protein nucleic acid enzyme publication_status: published publisher: Kyoritsu Shuppan publist_id: '4261' quality_controlled: 0 status: public title: Function and distribution of glutamate receptors in the central synapses type: review volume: 49 year: '2004' ... --- _id: '2645' abstract: - lang: eng text: 'The globus pallidus (GP) is a critical component of the basal ganglia circuitry controlling motor behavior. Dysregulation of GP activity has been implicated in a number of psychomotor disorders, including Parkinson''s disease (PD), in which a cardinal feature of the pathophysiology is an alteration in the pattern and synchrony of discharge in GP neurons. Yet the determinants of this activity in GP neurons are poorly understood. To help fill this gap, electrophysiological, molecular, and computational approaches were used to identify and characterize GABAergic GP neurons in tissue slices from rodents. In vitro, GABAergic GP neurons generate a regular, autonomous, single-spike pacemaker activity. Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels make an important contribution to this process: their blockade with ZD7288 significantly slowed discharge rate and decreased its regularity. HCN currents evoked by somatic voltage clamp had fast and slow components. Single-cell RT-PCR and immunohistochemical approaches revealed robust expression of HCN2 subunits as well as significant levels of HCN1 subunits in GABAergic GP neurons. Transient activation of striatal GABAergic input to GP neurons led to a resetting of rhythmic discharge that was dependent on HCN currents. Simulations suggested that the ability of transient striatal GABAergic input to reset pacemaking was dependent on dendritic HCN2/HCN1 channels. Together, these studies show that HCN channels in GABAergic GP neurons are key determinants of the regularity and rate of pacemaking as well as striatal resetting of this activity, implicating HCN channels in the emergence of synchrony in PD.' author: - first_name: Savio full_name: Chan, Savio last_name: Chan - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Jeff full_name: Mercer, Jeff N last_name: Mercer - first_name: James full_name: Surmeier, James D last_name: Surmeier citation: ama: Chan S, Shigemoto R, Mercer J, Surmeier J. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. Journal of Neuroscience. 2004;24(44):9921-9932. doi:10.1523/JNEUROSCI.2162-04.2004 apa: Chan, S., Shigemoto, R., Mercer, J., & Surmeier, J. (2004). HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.2162-04.2004 chicago: Chan, Savio, Ryuichi Shigemoto, Jeff Mercer, and James Surmeier. “HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons.” Journal of Neuroscience. Society for Neuroscience, 2004. https://doi.org/10.1523/JNEUROSCI.2162-04.2004. ieee: S. Chan, R. Shigemoto, J. Mercer, and J. Surmeier, “HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons,” Journal of Neuroscience, vol. 24, no. 44. Society for Neuroscience, pp. 9921–9932, 2004. ista: Chan S, Shigemoto R, Mercer J, Surmeier J. 2004. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. Journal of Neuroscience. 24(44), 9921–9932. mla: Chan, Savio, et al. “HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons.” Journal of Neuroscience, vol. 24, no. 44, Society for Neuroscience, 2004, pp. 9921–32, doi:10.1523/JNEUROSCI.2162-04.2004. short: S. Chan, R. Shigemoto, J. Mercer, J. Surmeier, Journal of Neuroscience 24 (2004) 9921–9932. date_created: 2018-12-11T11:58:51Z date_published: 2004-11-03T00:00:00Z date_updated: 2021-01-12T06:58:47Z day: '03' doi: 10.1523/JNEUROSCI.2162-04.2004 extern: 1 intvolume: ' 24' issue: '44' month: '11' page: 9921 - 9932 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '4252' quality_controlled: 0 status: public title: HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons type: journal_article volume: 24 year: '2004' ... --- _id: '2644' abstract: - lang: eng text: The release of GABA in synapses is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We tested whether GABA release to identified hippocampal neurons is influenced by group III mGluR activation using the agonist L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) on inhibitory postsynaptic currents (IPSCs) evoked in CA1 interneurons and pyramidal cells. In interneurons, characterized with biocytin and immunolabelling for somatostatin, evoked IPSCs were depressed by 50 μM L-AP4 (activating mGluR4 and 8) to 68±6% of control, but they were rarely depressed in pyramidal cells (96±4% of control). At 300-500 μM concentration (activating mGluR4, 7 and 8), L-AP4 depressed IPSCs in both interneurons (to 70±6%) and pyramidal cells (to 67±4%). The change in trial-to-trial variability and in paired-pulse depression indicated a presynaptic action. In interneurons, the degree of IPSC depression was variable (to 9-87%), and a third of IPSCs were not affected by L-AP4. The L-AP4-evoked IPSC depression was blocked by LY341495. The depression of IPSCs was similar in O-LM cells and other interneurons. The lack of cell-type selectivity and the similar efficacy of different concentrations of L-AP4 suggest that several group III mGluRs are involved in the depression of IPSCs. Electron microscopic immunocytochemistry confirmed that mGluR4, mGluR7a and mGluR8a occur in the presynaptic active zone of GABAergic terminals on interneurons, but not on those innervating pyramidal cells. The high variability of L-AP4-evoked IPSC suppression is in line with the selective expression of presynaptic mGluRs by several distinct types of GABAergic neuron innervating each interneuron type. author: - first_name: Naoki full_name: Kogo, Naoki last_name: Kogo - first_name: Yannis full_name: Dalezios, Yannis last_name: Dalezios - first_name: Marco full_name: Capogna,Marco last_name: Capogna - first_name: Francesco full_name: Ferraguti, Francesco last_name: Ferraguti - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi citation: ama: Kogo N, Dalezios Y, Capogna M, Ferraguti F, Shigemoto R, Somogyi P. Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat. European Journal of Neuroscience. 2004;19(10):2727-2740. doi:10.1111/j.0953-816X.2004.03394.x apa: Kogo, N., Dalezios, Y., Capogna, M., Ferraguti, F., Shigemoto, R., & Somogyi, P. (2004). Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.0953-816X.2004.03394.x chicago: Kogo, Naoki, Yannis Dalezios, Marco Capogna, Francesco Ferraguti, Ryuichi Shigemoto, and Péter Somogyi. “Depression of GABAergic Input to Identified Hippocampal Neurons by Group III Metabotropic Glutamate Receptors in the Rat.” European Journal of Neuroscience. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.0953-816X.2004.03394.x. ieee: N. Kogo, Y. Dalezios, M. Capogna, F. Ferraguti, R. Shigemoto, and P. Somogyi, “Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat,” European Journal of Neuroscience, vol. 19, no. 10. Wiley-Blackwell, pp. 2727–2740, 2004. ista: Kogo N, Dalezios Y, Capogna M, Ferraguti F, Shigemoto R, Somogyi P. 2004. Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat. European Journal of Neuroscience. 19(10), 2727–2740. mla: Kogo, Naoki, et al. “Depression of GABAergic Input to Identified Hippocampal Neurons by Group III Metabotropic Glutamate Receptors in the Rat.” European Journal of Neuroscience, vol. 19, no. 10, Wiley-Blackwell, 2004, pp. 2727–40, doi:10.1111/j.0953-816X.2004.03394.x. short: N. Kogo, Y. Dalezios, M. Capogna, F. Ferraguti, R. Shigemoto, P. Somogyi, European Journal of Neuroscience 19 (2004) 2727–2740. date_created: 2018-12-11T11:58:50Z date_published: 2004-05-01T00:00:00Z date_updated: 2021-01-12T06:58:46Z day: '01' doi: 10.1111/j.0953-816X.2004.03394.x extern: 1 intvolume: ' 19' issue: '10' month: '05' page: 2727 - 2740 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4255' quality_controlled: 0 status: public title: Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat type: journal_article volume: 19 year: '2004' ... --- _id: '2646' abstract: - lang: eng text: Metabotropic γ-aminobutyric acid receptors (GABAB) play modulatory roles in central synaptic transmission and are involved in controlling neuronal migration during development. We used immunohistochemical methods to elucidate the expression pattern as well as the cellular and the precise subcellular localization of the GABAB1a/b and GABAB2 subunits in the rat hippocampus during prenatal and postnatal development. At the light microscopic level, both GABABB1a/b and GABAB2 were expressed in the hippocampal primordium from embryonic day E14. During postnatal development, immunoreactivity for GABAB1a/b and GABAB2 was distributed mainly in pyramidal cells, with discrete GABABB1a/b-immunopositive cell bodies of interneurons present throughout the hippocampus. Using double immunofluorescence, we demonstrated that during the second week of postnatal development, GABAB1a/b but not GABAB2 was expressed in glial cells throughout the hippocampal formation. At the electron microscopic level, GABAB1a/b and GABAB2 showed a similar distribution pattern during postnatal development. Thus, at all ages the two receptor subunits were located postsynaptically in dendritic spines and shafts at extrasynaptic and perisynaptic sites in both pyramidal and nonpyramidal cells. We further demonstrated that the two subunits were localized presynaptically along the extrasynaptic plasma membrane of axon terminals and along the presynaptic active zone in both asymmetrical and, to a lesser extent, symmetrical synapses. These results suggest that GABAB receptors are widely expressed in the hippocampus throughout development and that GABABB1a/b and GABAB2 form both pre- and postsynaptic receptors. author: - first_name: Guillermina full_name: López-Bendito, Guillermina last_name: López Bendito - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Alfonso full_name: Fairén, Alfonso last_name: Fairén - first_name: Rafael full_name: Luján, Rafael last_name: Luján citation: ama: López Bendito G, Shigemoto R, Kulik Á, Vida I, Fairén A, Luján R. Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development. Hippocampus. 2004;14(7):836-848. doi:10.1002/hipo.10221 apa: López Bendito, G., Shigemoto, R., Kulik, Á., Vida, I., Fairén, A., & Luján, R. (2004). Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development. Hippocampus. Wiley-Blackwell. https://doi.org/10.1002/hipo.10221 chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Ákos Kulik, Imre Vida, Alfonso Fairén, and Rafael Luján. “ Distribution of Metabotropic GABA Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus during Prenatal and Postnatal Development.” Hippocampus. Wiley-Blackwell, 2004. https://doi.org/10.1002/hipo.10221. ieee: G. López Bendito, R. Shigemoto, Á. Kulik, I. Vida, A. Fairén, and R. Luján, “ Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development,” Hippocampus, vol. 14, no. 7. Wiley-Blackwell, pp. 836–848, 2004. ista: López Bendito G, Shigemoto R, Kulik Á, Vida I, Fairén A, Luján R. 2004. Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development. Hippocampus. 14(7), 836–848. mla: López Bendito, Guillermina, et al. “ Distribution of Metabotropic GABA Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus during Prenatal and Postnatal Development.” Hippocampus, vol. 14, no. 7, Wiley-Blackwell, 2004, pp. 836–48, doi:10.1002/hipo.10221. short: G. López Bendito, R. Shigemoto, Á. Kulik, I. Vida, A. Fairén, R. Luján, Hippocampus 14 (2004) 836–848. date_created: 2018-12-11T11:58:51Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T06:58:47Z day: '01' doi: 10.1002/hipo.10221 extern: 1 intvolume: ' 14' issue: '7' month: '01' page: 836 - 848 publication: Hippocampus publication_status: published publisher: Wiley-Blackwell publist_id: '4251' quality_controlled: 0 status: public title: ' Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development' type: journal_article volume: 14 year: '2004' ... --- _id: '2706' abstract: - lang: eng text: The Pauli operator describes the energy of a nonrelativistic quantum particle with spin in a magnetic field and an external potential. Bounds on the sum of the negative eigenvalues are called magnetic Lieb-Thirring (MLT) inequalities. The purpose of this paper is twofold. First, we prove a new MLT inequality in a simple way. Second, we give a short summary of our recent proof of a more refined MLT inequality(8) and we explain the differences between the two results and methods. The main feature of both estimates, compared to earlier results, is that in the large field regime they grow with the optimal (first) power of the strength of the magnetic field. As a byproduct of the method, we also obtain optimal upper bounds on the pointwise density of zero energy eigenfunctions of the Dirac operator. author: - first_name: László full_name: László Erdös id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Jan full_name: Solovej, Jan P last_name: Solovej citation: ama: Erdös L, Solovej J. Magnetic Lieb-Thirring inequalities with optimal dependence on the field strength. Journal of Statistical Physics. 2004;116(1-4):475-506. doi:10.1023/B:JOSS.0000037216.45270.1d apa: Erdös, L., & Solovej, J. (2004). Magnetic Lieb-Thirring inequalities with optimal dependence on the field strength. Journal of Statistical Physics. Springer. https://doi.org/10.1023/B:JOSS.0000037216.45270.1d chicago: Erdös, László, and Jan Solovej. “Magnetic Lieb-Thirring Inequalities with Optimal Dependence on the Field Strength.” Journal of Statistical Physics. Springer, 2004. https://doi.org/10.1023/B:JOSS.0000037216.45270.1d. ieee: L. Erdös and J. Solovej, “Magnetic Lieb-Thirring inequalities with optimal dependence on the field strength,” Journal of Statistical Physics, vol. 116, no. 1–4. Springer, pp. 475–506, 2004. ista: Erdös L, Solovej J. 2004. Magnetic Lieb-Thirring inequalities with optimal dependence on the field strength. Journal of Statistical Physics. 116(1–4), 475–506. mla: Erdös, László, and Jan Solovej. “Magnetic Lieb-Thirring Inequalities with Optimal Dependence on the Field Strength.” Journal of Statistical Physics, vol. 116, no. 1–4, Springer, 2004, pp. 475–506, doi:10.1023/B:JOSS.0000037216.45270.1d. short: L. Erdös, J. Solovej, Journal of Statistical Physics 116 (2004) 475–506. date_created: 2018-12-11T11:59:10Z date_published: 2004-08-01T00:00:00Z date_updated: 2021-01-12T06:59:10Z day: '01' doi: 10.1023/B:JOSS.0000037216.45270.1d extern: 1 intvolume: ' 116' issue: 1-4 month: '08' page: 475 - 506 publication: Journal of Statistical Physics publication_status: published publisher: Springer publist_id: '4190' quality_controlled: 0 status: public title: Magnetic Lieb-Thirring inequalities with optimal dependence on the field strength type: journal_article volume: 116 year: '2004' ... --- _id: '2707' abstract: - lang: eng text: We give a nonrigorous derivation of the nonlinear Boltzmann equation from the Schrödinger evolution of interacting fermions. The argument is based mainly on the assumption that a quasifree initial state satisfies a property called restricted quasifreeness in the weak coupling limit at any later time. By definition, a state is called restricted quasifree if the four-point and the eight-point functions of the state factorize in the same manner as in a quasifree state. author: - first_name: László full_name: László Erdös id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Manfred full_name: Salmhofer, Manfred last_name: Salmhofer - first_name: Horng full_name: Yau, Horng-Tzer last_name: Yau citation: ama: Erdös L, Salmhofer M, Yau H. On the quantum Boltzmann equation. Journal of Statistical Physics. 2004;116(1-4):367-380. doi:10.1023/B:JOSS.0000037224.56191.ed apa: Erdös, L., Salmhofer, M., & Yau, H. (2004). On the quantum Boltzmann equation. Journal of Statistical Physics. Springer. https://doi.org/10.1023/B:JOSS.0000037224.56191.ed chicago: Erdös, László, Manfred Salmhofer, and Horng Yau. “On the Quantum Boltzmann Equation.” Journal of Statistical Physics. Springer, 2004. https://doi.org/10.1023/B:JOSS.0000037224.56191.ed. ieee: L. Erdös, M. Salmhofer, and H. Yau, “On the quantum Boltzmann equation,” Journal of Statistical Physics, vol. 116, no. 1–4. Springer, pp. 367–380, 2004. ista: Erdös L, Salmhofer M, Yau H. 2004. On the quantum Boltzmann equation. Journal of Statistical Physics. 116(1–4), 367–380. mla: Erdös, László, et al. “On the Quantum Boltzmann Equation.” Journal of Statistical Physics, vol. 116, no. 1–4, Springer, 2004, pp. 367–80, doi:10.1023/B:JOSS.0000037224.56191.ed. short: L. Erdös, M. Salmhofer, H. Yau, Journal of Statistical Physics 116 (2004) 367–380. date_created: 2018-12-11T11:59:11Z date_published: 2004-08-01T00:00:00Z date_updated: 2021-01-12T06:59:11Z day: '01' doi: 10.1023/B:JOSS.0000037224.56191.ed extern: 1 intvolume: ' 116' issue: 1-4 month: '08' page: 367 - 380 publication: Journal of Statistical Physics publication_status: published publisher: Springer publist_id: '4189' quality_controlled: 0 status: public title: On the quantum Boltzmann equation type: journal_article volume: 116 year: '2004' ... --- _id: '2741' abstract: - lang: eng text: 'The Pauli operator describes the energy of a nonrelativistic quantum particle with spin 1/2 in a magnetic field and an external potential. A new Lieb-Thirring type inequality on the sum of the negative eigenvalues is presented. The main feature compared to earlier results is that in the large field regime the present estimate grows with the optimal (first) power of the strength of the magnetic field. As a byproduct of the method, we also obtain an optimal upper bound on the pointwise density of zero energy eigenfunctions of the Dirac operator. The main technical tools are: (i) a new localization scheme for the square of the resolvent of a general class of second order elliptic operators; (ii) a geometric construction of a Dirac operator with a constant magnetic field that approximates the original Dirac operator in a tubular neighborhood of a fixed field line. The errors may depend on the regularity of the magnetic field but they are uniform in the field strength.' author: - first_name: László full_name: László Erdös id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Jan full_name: Solovej, Jan P last_name: Solovej citation: ama: Erdös L, Solovej J. Uniform Lieb-Thirring inequality for the three-dimensional Pauli operator with a strong non-homogeneous magnetic field. Annales Henri Poincare. 2004;5(4):671-741. doi:10.1007/s00023-004-0180-x apa: Erdös, L., & Solovej, J. (2004). Uniform Lieb-Thirring inequality for the three-dimensional Pauli operator with a strong non-homogeneous magnetic field. Annales Henri Poincare. Birkhäuser. https://doi.org/10.1007/s00023-004-0180-x chicago: Erdös, László, and Jan Solovej. “Uniform Lieb-Thirring Inequality for the Three-Dimensional Pauli Operator with a Strong Non-Homogeneous Magnetic Field.” Annales Henri Poincare. Birkhäuser, 2004. https://doi.org/10.1007/s00023-004-0180-x. ieee: L. Erdös and J. Solovej, “Uniform Lieb-Thirring inequality for the three-dimensional Pauli operator with a strong non-homogeneous magnetic field,” Annales Henri Poincare, vol. 5, no. 4. Birkhäuser, pp. 671–741, 2004. ista: Erdös L, Solovej J. 2004. Uniform Lieb-Thirring inequality for the three-dimensional Pauli operator with a strong non-homogeneous magnetic field. Annales Henri Poincare. 5(4), 671–741. mla: Erdös, László, and Jan Solovej. “Uniform Lieb-Thirring Inequality for the Three-Dimensional Pauli Operator with a Strong Non-Homogeneous Magnetic Field.” Annales Henri Poincare, vol. 5, no. 4, Birkhäuser, 2004, pp. 671–741, doi:10.1007/s00023-004-0180-x. short: L. Erdös, J. Solovej, Annales Henri Poincare 5 (2004) 671–741. date_created: 2018-12-11T11:59:21Z date_published: 2004-08-01T00:00:00Z date_updated: 2021-01-12T06:59:24Z day: '01' doi: 10.1007/s00023-004-0180-x extern: 1 intvolume: ' 5' issue: '4' month: '08' page: 671 - 741 publication: Annales Henri Poincare publication_status: published publisher: Birkhäuser publist_id: '4151' quality_controlled: 0 status: public title: Uniform Lieb-Thirring inequality for the three-dimensional Pauli operator with a strong non-homogeneous magnetic field type: journal_article volume: 5 year: '2004' ... --- _id: '2742' abstract: - lang: eng text: We consider a system of N weakly interacting fermions with a real analytic pair interaction. We prove that for a general class of initial data there exists a fixed time T such that the difference between the one particle density matrix of this system and the solution of the nonlinear Hartree equation is of order N−1 for any time t⩽T. author: - first_name: Alexander full_name: Elgart, Alexander last_name: Elgart - first_name: László full_name: László Erdös id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Benjamin full_name: Schlein, Benjamin last_name: Schlein - first_name: Horng full_name: Yau, Horng-Tzer last_name: Yau citation: ama: Elgart A, Erdös L, Schlein B, Yau H. Nonlinear Hartree equation as the mean field limit of weakly coupled fermions. Journal de Mathématiques Pures et Appliquées. 2004;83(10):1241-1273. doi:10.1016/j.matpur.2004.03.006 apa: Elgart, A., Erdös, L., Schlein, B., & Yau, H. (2004). Nonlinear Hartree equation as the mean field limit of weakly coupled fermions. Journal de Mathématiques Pures et Appliquées. Elsevier. https://doi.org/10.1016/j.matpur.2004.03.006 chicago: Elgart, Alexander, László Erdös, Benjamin Schlein, and Horng Yau. “Nonlinear Hartree Equation as the Mean Field Limit of Weakly Coupled Fermions.” Journal de Mathématiques Pures et Appliquées. Elsevier, 2004. https://doi.org/10.1016/j.matpur.2004.03.006. ieee: A. Elgart, L. Erdös, B. Schlein, and H. Yau, “Nonlinear Hartree equation as the mean field limit of weakly coupled fermions,” Journal de Mathématiques Pures et Appliquées, vol. 83, no. 10. Elsevier, pp. 1241–1273, 2004. ista: Elgart A, Erdös L, Schlein B, Yau H. 2004. Nonlinear Hartree equation as the mean field limit of weakly coupled fermions. Journal de Mathématiques Pures et Appliquées. 83(10), 1241–1273. mla: Elgart, Alexander, et al. “Nonlinear Hartree Equation as the Mean Field Limit of Weakly Coupled Fermions.” Journal de Mathématiques Pures et Appliquées, vol. 83, no. 10, Elsevier, 2004, pp. 1241–73, doi:10.1016/j.matpur.2004.03.006. short: A. Elgart, L. Erdös, B. Schlein, H. Yau, Journal de Mathématiques Pures et Appliquées 83 (2004) 1241–1273. date_created: 2018-12-11T11:59:22Z date_published: 2004-10-01T00:00:00Z date_updated: 2021-01-12T06:59:24Z day: '01' doi: 10.1016/j.matpur.2004.03.006 extern: 1 intvolume: ' 83' issue: '10' month: '10' page: 1241 - 1273 publication: Journal de Mathématiques Pures et Appliquées publication_status: published publisher: Elsevier publist_id: '4150' quality_controlled: 0 status: public title: Nonlinear Hartree equation as the mean field limit of weakly coupled fermions type: journal_article volume: 83 year: '2004' ... --- _id: '2787' abstract: - lang: eng text: The results of experimental and numerical investigations of the onset of oscillatory convection in a sidewall heated rectangular cavity of molten gallium are reported. Detailed comparisons are made between experimental observations and calculations from numerical simulations of a three-dimensional Boussinesq model. The onset of time-dependence takes place through supercritical Hopf bifurcations and the loci of critical points in the (Gr, Pr)-plane are qualitatively similar with excellent agreement between the frequencies of the oscillatory motion. This provides a severe test of the control of the experiment since the mode of oscillation is extremely sensitive to imperfections. Detailed numerical investigations reveal that there are a pair of Hopf bifurcations which exist on two asymmetric states which themselves arise at a subcritical pitchfork from the symmetric state. There is no evidence for this in the experiment and this qualitative difference is attributed to non-Boussinesq perturbations which increase with Gr. However, the antisymmetric spatial structure of the oscillatory state is robust and is present in both the experiment and the numerical model. Moreover, the detailed analysis of the numerical results reveals the origins of the oscillatory instability. author: - first_name: Björn full_name: Björn Hof id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 - first_name: Anne full_name: Juel, Anne last_name: Juel - first_name: Li full_name: Zhao, Li last_name: Zhao - first_name: Daniel full_name: 'Henry, Daniel ' last_name: Henry - first_name: Hamda full_name: Ben Hadid, Hamda last_name: Ben Hadid - first_name: Tom full_name: Mullin, Tom P last_name: Mullin citation: ama: Hof B, Juel A, Zhao L, Henry D, Ben Hadid H, Mullin T. On the onset of oscillatory convection in molten gallium. Journal of Fluid Mechanics. 2004;515:391-413. doi:10.1017/S0022112004000527 apa: Hof, B., Juel, A., Zhao, L., Henry, D., Ben Hadid, H., & Mullin, T. (2004). On the onset of oscillatory convection in molten gallium. Journal of Fluid Mechanics. Cambridge University Press. https://doi.org/10.1017/S0022112004000527 chicago: Hof, Björn, Anne Juel, Li Zhao, Daniel Henry, Hamda Ben Hadid, and Tom Mullin. “On the Onset of Oscillatory Convection in Molten Gallium.” Journal of Fluid Mechanics. Cambridge University Press, 2004. https://doi.org/10.1017/S0022112004000527. ieee: B. Hof, A. Juel, L. Zhao, D. Henry, H. Ben Hadid, and T. Mullin, “On the onset of oscillatory convection in molten gallium,” Journal of Fluid Mechanics, vol. 515. Cambridge University Press, pp. 391–413, 2004. ista: Hof B, Juel A, Zhao L, Henry D, Ben Hadid H, Mullin T. 2004. On the onset of oscillatory convection in molten gallium. Journal of Fluid Mechanics. 515, 391–413. mla: Hof, Björn, et al. “On the Onset of Oscillatory Convection in Molten Gallium.” Journal of Fluid Mechanics, vol. 515, Cambridge University Press, 2004, pp. 391–413, doi:10.1017/S0022112004000527. short: B. Hof, A. Juel, L. Zhao, D. Henry, H. Ben Hadid, T. Mullin, Journal of Fluid Mechanics 515 (2004) 391–413. date_created: 2018-12-11T11:59:36Z date_published: 2004-09-25T00:00:00Z date_updated: 2021-01-12T06:59:43Z day: '25' doi: 10.1017/S0022112004000527 extern: 1 intvolume: ' 515' month: '09' page: 391 - 413 publication: Journal of Fluid Mechanics publication_status: published publisher: Cambridge University Press publist_id: '4102' quality_controlled: 0 status: public title: On the onset of oscillatory convection in molten gallium type: journal_article volume: 515 year: '2004' ... --- _id: '2786' abstract: - lang: eng text: Transition to turbulence in pipe flow is one of the most fundamental and longest- standing problems in fluid dynamics. Stability theory suggests that the flow remains laminar for all flow rates, but in practice pipe flow becomes turbulent even at moderate speeds. This transition drastically affects the transport efficiency of mass, momentum, and heat. On the basis of the recent discovery of unstable traveling waves in computational studies of the Navier-Stokes equations and ideas from dynamical systems theory, a model for the transition process has been suggested. We report experimental observation of these traveling waves in pipe flow, confirming the proposed transition scenario and suggesting that the dynamics associated with these unstable states may indeed capture the nature of fluid turbulence. author: - first_name: Björn full_name: Björn Hof id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 - first_name: Casimir full_name: van Doorne, Casimir W last_name: Van Doorne - first_name: Jerry full_name: Westerweel, Jerry last_name: Westerweel - first_name: Frans full_name: Nieuwstadt, Frans T last_name: Nieuwstadt - first_name: Holger full_name: Faisst, Holger last_name: Faisst - first_name: Bruno full_name: Eckhardt, Bruno last_name: Eckhardt - first_name: Håkan full_name: Wedin, Håkan last_name: Wedin - first_name: Richard full_name: Kersweli, Richard R last_name: Kersweli - first_name: Fabian full_name: Waleffe, Fabian last_name: Waleffe citation: ama: Hof B, Van Doorne C, Westerweel J, et al. Experimental observation of nonlinear traveling waves in turbulent pipe flow. Science. 2004;305(5690):1594-1598. doi:10.1126/science.1100393 apa: Hof, B., Van Doorne, C., Westerweel, J., Nieuwstadt, F., Faisst, H., Eckhardt, B., … Waleffe, F. (2004). Experimental observation of nonlinear traveling waves in turbulent pipe flow. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1100393 chicago: Hof, Björn, Casimir Van Doorne, Jerry Westerweel, Frans Nieuwstadt, Holger Faisst, Bruno Eckhardt, Håkan Wedin, Richard Kersweli, and Fabian Waleffe. “Experimental Observation of Nonlinear Traveling Waves in Turbulent Pipe Flow.” Science. American Association for the Advancement of Science, 2004. https://doi.org/10.1126/science.1100393. ieee: B. Hof et al., “Experimental observation of nonlinear traveling waves in turbulent pipe flow,” Science, vol. 305, no. 5690. American Association for the Advancement of Science, pp. 1594–1598, 2004. ista: Hof B, Van Doorne C, Westerweel J, Nieuwstadt F, Faisst H, Eckhardt B, Wedin H, Kersweli R, Waleffe F. 2004. Experimental observation of nonlinear traveling waves in turbulent pipe flow. Science. 305(5690), 1594–1598. mla: Hof, Björn, et al. “Experimental Observation of Nonlinear Traveling Waves in Turbulent Pipe Flow.” Science, vol. 305, no. 5690, American Association for the Advancement of Science, 2004, pp. 1594–98, doi:10.1126/science.1100393. short: B. Hof, C. Van Doorne, J. Westerweel, F. Nieuwstadt, H. Faisst, B. Eckhardt, H. Wedin, R. Kersweli, F. Waleffe, Science 305 (2004) 1594–1598. date_created: 2018-12-11T11:59:35Z date_published: 2004-09-10T00:00:00Z date_updated: 2021-01-12T06:59:42Z day: '10' doi: 10.1126/science.1100393 extern: 1 intvolume: ' 305' issue: '5690' month: '09' page: 1594 - 1598 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '4103' quality_controlled: 0 status: public title: Experimental observation of nonlinear traveling waves in turbulent pipe flow type: journal_article volume: 305 year: '2004' ... --- _id: '2998' abstract: - lang: eng text: The packaging of the genomic DNA into chromatin in the cell nucleus requires machineries that facilitate DNA-dependent processes such as transcription in the presence of repressive chromatin structures. Using co-immunoprecipitation we have identified in Arabidopsis thaliana cells the FAcilitates Chromatin Transcription (FACT) complex, consisting of the 120-kDa Spt16 and the 71-kDa SSRP1 proteins. Indirect immunofluorecence analyses revealed that both FACT subunits co-localize to nuclei of the majority of cell types in embryos, shoots and roots, whereas FACT is not present in terminally differentiated cells such as mature trichoblasts or cells of the root cap. In the nucleus, Spt16 and SSRP1 are found in the cytologically defined euchromatin of interphase cells independent of the status of DNA replication, but the proteins are not associated with heterochromatic chromocentres and condensed mitotic chromosomes. FACT can be detected by chromatin immunoprecipitation over the entire transcribed region (5′-UTR, coding sequence, 3′-UTR) of actively transcribed genes, whereas it does not occur at transcriptionally inactive heterochromatic regions and intergenic regions. FACT localizes to inducible genes only after induction of transcription, and the association of the complex with the genes correlates with the level of transcription. Collectively, these results indicate that FACT assists transcription elongation through plant chromatin. author: - first_name: Meg full_name: Duroux, Meg last_name: Duroux - first_name: Andreas full_name: Houben, Andreas last_name: Houben - first_name: Kamil full_name: Růžička, Kamil last_name: Růžička - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Klaus full_name: Grasser, Klaus D last_name: Grasser citation: ama: Duroux M, Houben A, Růžička K, Friml J, Grasser K. The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome. Plant Journal. 2004;40(5):660-671. doi:10.1111/j.1365-313X.2004.02242.x apa: Duroux, M., Houben, A., Růžička, K., Friml, J., & Grasser, K. (2004). The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome. Plant Journal. Wiley-Blackwell. https://doi.org/10.1111/j.1365-313X.2004.02242.x chicago: Duroux, Meg, Andreas Houben, Kamil Růžička, Jiří Friml, and Klaus Grasser. “The Chromatin Remodelling Complex FACT Associates with Actively Transcribed Regions of the Arabidopsis Genome.” Plant Journal. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.1365-313X.2004.02242.x. ieee: M. Duroux, A. Houben, K. Růžička, J. Friml, and K. Grasser, “The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome,” Plant Journal, vol. 40, no. 5. Wiley-Blackwell, pp. 660–671, 2004. ista: Duroux M, Houben A, Růžička K, Friml J, Grasser K. 2004. The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome. Plant Journal. 40(5), 660–671. mla: Duroux, Meg, et al. “The Chromatin Remodelling Complex FACT Associates with Actively Transcribed Regions of the Arabidopsis Genome.” Plant Journal, vol. 40, no. 5, Wiley-Blackwell, 2004, pp. 660–71, doi:10.1111/j.1365-313X.2004.02242.x. short: M. Duroux, A. Houben, K. Růžička, J. Friml, K. Grasser, Plant Journal 40 (2004) 660–671. date_created: 2018-12-11T12:00:47Z date_published: 2004-12-01T00:00:00Z date_updated: 2021-01-12T07:40:20Z day: '01' doi: 10.1111/j.1365-313X.2004.02242.x extern: 1 intvolume: ' 40' issue: '5' month: '12' page: 660 - 671 publication: Plant Journal publication_status: published publisher: Wiley-Blackwell publist_id: '3703' quality_controlled: 0 status: public title: The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome type: journal_article volume: 40 year: '2004' ... --- _id: '2997' abstract: - lang: eng text: Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes. author: - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Xiong full_name: Yang, Xiong last_name: Yang - first_name: Marta full_name: Michniewicz, Marta last_name: Michniewicz - first_name: Dolf full_name: Weijers, Dolf last_name: Weijers - first_name: Ab full_name: Quint, Ab last_name: Quint - first_name: Olaf full_name: Tietz, Olaf last_name: Tietz - first_name: René full_name: Benjamins, René last_name: Benjamins - first_name: Pieter full_name: Ouwerkerk, Pieter B last_name: Ouwerkerk - first_name: Karin full_name: Ljung, Karin last_name: Ljung - first_name: Göran full_name: Sandberg, Göran last_name: Sandberg - first_name: Paul full_name: Hooykaas, Paul J last_name: Hooykaas - first_name: Klaus full_name: Palme, Klaus last_name: Palme - first_name: Remko full_name: Offringa, Remko last_name: Offringa citation: ama: Friml J, Yang X, Michniewicz M, et al. A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science. 2004;306(5697):862-865. doi:10.1126/science.1100618 apa: Friml, J., Yang, X., Michniewicz, M., Weijers, D., Quint, A., Tietz, O., … Offringa, R. (2004). A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1100618 chicago: Friml, Jiří, Xiong Yang, Marta Michniewicz, Dolf Weijers, Ab Quint, Olaf Tietz, René Benjamins, et al. “A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux.” Science. American Association for the Advancement of Science, 2004. https://doi.org/10.1126/science.1100618. ieee: J. Friml et al., “A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux,” Science, vol. 306, no. 5697. American Association for the Advancement of Science, pp. 862–865, 2004. ista: Friml J, Yang X, Michniewicz M, Weijers D, Quint A, Tietz O, Benjamins R, Ouwerkerk P, Ljung K, Sandberg G, Hooykaas P, Palme K, Offringa R. 2004. A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science. 306(5697), 862–865. mla: Friml, Jiří, et al. “A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux.” Science, vol. 306, no. 5697, American Association for the Advancement of Science, 2004, pp. 862–65, doi:10.1126/science.1100618. short: J. Friml, X. Yang, M. Michniewicz, D. Weijers, A. Quint, O. Tietz, R. Benjamins, P. Ouwerkerk, K. Ljung, G. Sandberg, P. Hooykaas, K. Palme, R. Offringa, Science 306 (2004) 862–865. date_created: 2018-12-11T12:00:46Z date_published: 2004-10-29T00:00:00Z date_updated: 2021-01-12T07:40:20Z day: '29' doi: 10.1126/science.1100618 extern: 1 intvolume: ' 306' issue: '5697' month: '10' page: 862 - 865 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '3705' quality_controlled: 0 status: public title: A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux type: journal_article volume: 306 year: '2004' ... --- _id: '2999' abstract: - lang: eng text: Embryogenesis of flowering plants establishes a basic body plan with apical-basal, radial and bilateral patterns from the single-celled zygote. Arabidopsis embryogenesis exhibits a nearly invariant cell division pattern and therefore is an ideal system for studies of early plant development. However, plant embryos are difficult to access for experimental manipulation, as they develop deeply inside maternal tissues. Here we present a method for the culture of zygotic Arabidopsis embryos in vitro. The technique omits excision of the embryo by culturing the entire ovule, thus greatly facilitating the time and effort involved. It enables external manipulation of embryo development and culture from the earliest developmental stages up to maturity. Administration of various chemical treatments as well as the use of different molecular markers is demonstrated together with standard techniques for visualizing gene expression and protein localization in in vitro cultivated embryos. The presented set of techniques allows for so far unavailable molecular physiology approaches in the study of early plant development. author: - first_name: Michael full_name: Sauer, Michael last_name: Sauer - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Sauer M, Friml J. In vitro culture of Arabidopsis embryos within their ovules. Plant Journal. 2004;40(5):835-843. doi:10.1111/j.1365-313X.2004.02248.x apa: Sauer, M., & Friml, J. (2004). In vitro culture of Arabidopsis embryos within their ovules. Plant Journal. Wiley-Blackwell. https://doi.org/10.1111/j.1365-313X.2004.02248.x chicago: Sauer, Michael, and Jiří Friml. “In Vitro Culture of Arabidopsis Embryos within Their Ovules.” Plant Journal. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.1365-313X.2004.02248.x. ieee: M. Sauer and J. Friml, “In vitro culture of Arabidopsis embryos within their ovules,” Plant Journal, vol. 40, no. 5. Wiley-Blackwell, pp. 835–843, 2004. ista: Sauer M, Friml J. 2004. In vitro culture of Arabidopsis embryos within their ovules. Plant Journal. 40(5), 835–843. mla: Sauer, Michael, and Jiří Friml. “In Vitro Culture of Arabidopsis Embryos within Their Ovules.” Plant Journal, vol. 40, no. 5, Wiley-Blackwell, 2004, pp. 835–43, doi:10.1111/j.1365-313X.2004.02248.x. short: M. Sauer, J. Friml, Plant Journal 40 (2004) 835–843. date_created: 2018-12-11T12:00:47Z date_published: 2004-12-01T00:00:00Z date_updated: 2021-01-12T07:40:20Z day: '01' doi: 10.1111/j.1365-313X.2004.02248.x extern: 1 intvolume: ' 40' issue: '5' month: '12' page: 835 - 843 publication: Plant Journal publication_status: published publisher: Wiley-Blackwell publist_id: '3704' quality_controlled: 0 status: public title: In vitro culture of Arabidopsis embryos within their ovules type: journal_article volume: 40 year: '2004' ... --- _id: '3208' abstract: - lang: eng text: |- A new technique for proving the adaptive indistinguishability of two systems, each composed of some component systems, is presented, using only the fact that corresponding component systems are non-adaptively indistinguishable. The main tool is the definition of a special monotone condition for a random system F, relative to another random system G, whose probability of occurring for a given distinguisher D is closely related to the distinguishing advantage ε of D for F and G, namely it is lower and upper bounded by ε and (1+ln1), respectively. A concrete instantiation of this result shows that the cascade of two random permutations (with the second one inverted) is indistinguishable from a uniform random permutation by adaptive distinguishers which may query the system from both sides, assuming the components’ security only against non-adaptive one-sided distinguishers. As applications we provide some results in various fields as almost k-wise independent probability spaces, decorrelation theory and computational indistinguishability (i.e., pseudo-randomness). alternative_title: - LNCS author: - first_name: Ueli full_name: Maurer, Ueli M last_name: Maurer - first_name: Krzysztof Z full_name: Krzysztof Pietrzak id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 citation: ama: 'Maurer U, Pietrzak KZ. Composition of random systems: When two weak make one strong. In: Vol 2951. Springer; 2004:410-427. doi:10.1007/978-3-540-24638-1_23' apa: 'Maurer, U., & Pietrzak, K. Z. (2004). Composition of random systems: When two weak make one strong (Vol. 2951, pp. 410–427). Presented at the TCC: Theory of Cryptography Conference, Springer. https://doi.org/10.1007/978-3-540-24638-1_23' chicago: 'Maurer, Ueli, and Krzysztof Z Pietrzak. “Composition of Random Systems: When Two Weak Make One Strong,” 2951:410–27. Springer, 2004. https://doi.org/10.1007/978-3-540-24638-1_23.' ieee: 'U. Maurer and K. Z. Pietrzak, “Composition of random systems: When two weak make one strong,” presented at the TCC: Theory of Cryptography Conference, 2004, vol. 2951, pp. 410–427.' ista: 'Maurer U, Pietrzak KZ. 2004. Composition of random systems: When two weak make one strong. TCC: Theory of Cryptography Conference, LNCS, vol. 2951, 410–427.' mla: 'Maurer, Ueli, and Krzysztof Z. Pietrzak. Composition of Random Systems: When Two Weak Make One Strong. Vol. 2951, Springer, 2004, pp. 410–27, doi:10.1007/978-3-540-24638-1_23.' short: U. Maurer, K.Z. Pietrzak, in:, Springer, 2004, pp. 410–427. conference: name: 'TCC: Theory of Cryptography Conference' date_created: 2018-12-11T12:02:01Z date_published: 2004-03-19T00:00:00Z date_updated: 2021-01-12T07:41:48Z day: '19' doi: 10.1007/978-3-540-24638-1_23 extern: 1 intvolume: ' 2951' month: '03' page: 410 - 427 publication_status: published publisher: Springer publist_id: '3471' quality_controlled: 0 status: public title: 'Composition of random systems: When two weak make one strong' type: conference volume: 2951 year: '2004' ... --- _id: '3587' alternative_title: - Molecular Aspects of Fish and Marine Biology article_processing_charge: No author: - first_name: Florian full_name: Ulrich, Florian last_name: Ulrich - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: 'Ulrich F, Heisenberg C-PJ. Gastrulation in zebrafish. In: Korzh V, Gong Z, eds. Fish Development and Genetics : The Zebrafish and Medaka Models. Vol 2. World Scientific Publishing; 2004:39-86.' apa: 'Ulrich, F., & Heisenberg, C.-P. J. (2004). Gastrulation in zebrafish. In V. Korzh & Z. Gong (Eds.), Fish development and genetics : the zebrafish and medaka models (Vol. 2, pp. 39–86). World Scientific Publishing.' chicago: 'Ulrich, Florian, and Carl-Philipp J Heisenberg. “Gastrulation in Zebrafish.” In Fish Development and Genetics : The Zebrafish and Medaka Models, edited by Vladimir Korzh and Zhiyuan Gong, 2:39–86. World Scientific Publishing, 2004.' ieee: 'F. Ulrich and C.-P. J. Heisenberg, “Gastrulation in zebrafish,” in Fish development and genetics : the zebrafish and medaka models, vol. 2, V. Korzh and Z. Gong, Eds. World Scientific Publishing, 2004, pp. 39–86.' ista: 'Ulrich F, Heisenberg C-PJ. 2004.Gastrulation in zebrafish. In: Fish development and genetics : the zebrafish and medaka models. Molecular Aspects of Fish and Marine Biology, vol. 2, 39–86.' mla: 'Ulrich, Florian, and Carl-Philipp J. Heisenberg. “Gastrulation in Zebrafish.” Fish Development and Genetics : The Zebrafish and Medaka Models, edited by Vladimir Korzh and Zhiyuan Gong, vol. 2, World Scientific Publishing, 2004, pp. 39–86.' short: 'F. Ulrich, C.-P.J. Heisenberg, in:, V. Korzh, Z. Gong (Eds.), Fish Development and Genetics : The Zebrafish and Medaka Models, World Scientific Publishing, 2004, pp. 39–86.' date_created: 2018-12-11T12:04:06Z date_published: 2004-11-01T00:00:00Z date_updated: 2021-01-12T07:44:29Z day: '01' editor: - first_name: Vladimir full_name: Korzh, Vladimir last_name: Korzh - first_name: Zhiyuan full_name: Gong, Zhiyuan last_name: Gong extern: '1' intvolume: ' 2' language: - iso: eng month: '11' oa_version: None page: 39 - 86 publication: 'Fish development and genetics : the zebrafish and medaka models' publication_status: published publisher: World Scientific Publishing publist_id: '2796' status: public title: Gastrulation in zebrafish type: book_chapter user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 2 year: '2004' ... --- _id: '3617' abstract: - lang: eng text: 'The coalescent process can describe the effects of selection at linked loci only if selection is so strong that genotype frequencies evolve deterministically. Here, we develop methods proposed by Kaplan, Darden, and Hudson to find the effects of weak selection. We show that the overall effect is given by an extension to Price''s equation: the change in properties such as moments of coalescence times is equal to the covariance between those properties and the fitness of the sample of genes. The distribution of coalescence times differs substantially between allelic classes, even in the absence of selection. However, the average coalescence time between randomly chosen genes is insensitive to the current allele frequency and is affected significantly by purifying selection only if deleterious mutations are common and selection is strong (i.e., the product of population size and selection coefficient, Ns > 3). Balancing selection increases mean coalescence times, but the effect becomes large only when mutation rates between allelic classes are low and when selection is extremely strong. Our analysis supports previous simulations that show that selection has surprisingly little effect on genealogies. Moreover, small fluctuations in allele frequency due to random drift can greatly reduce any such effects. This will make it difficult to detect the action of selection from neutral variation alone.' author: - first_name: Nicholas H full_name: Nicholas Barton id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Alison full_name: Etheridge, Alison M last_name: Etheridge citation: ama: Barton NH, Etheridge A. The effect of selection on genealogies. Genetics. 2004;166(2):1115-1131. doi:10.1534/genetics.166.2.1115 apa: Barton, N. H., & Etheridge, A. (2004). The effect of selection on genealogies. Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.166.2.1115 chicago: Barton, Nicholas H, and Alison Etheridge. “The Effect of Selection on Genealogies.” Genetics. Genetics Society of America, 2004. https://doi.org/10.1534/genetics.166.2.1115. ieee: N. H. Barton and A. Etheridge, “The effect of selection on genealogies,” Genetics, vol. 166, no. 2. Genetics Society of America, pp. 1115–1131, 2004. ista: Barton NH, Etheridge A. 2004. The effect of selection on genealogies. Genetics. 166(2), 1115–1131. mla: Barton, Nicholas H., and Alison Etheridge. “The Effect of Selection on Genealogies.” Genetics, vol. 166, no. 2, Genetics Society of America, 2004, pp. 1115–31, doi:10.1534/genetics.166.2.1115. short: N.H. Barton, A. Etheridge, Genetics 166 (2004) 1115–1131. date_created: 2018-12-11T12:04:16Z date_published: 2004-02-01T00:00:00Z date_updated: 2021-01-12T07:44:41Z day: '01' doi: 10.1534/genetics.166.2.1115 extern: 1 intvolume: ' 166' issue: '2' month: '02' page: 1115 - 1131 publication: Genetics publication_status: published publisher: Genetics Society of America publist_id: '2766' quality_controlled: 0 status: public title: The effect of selection on genealogies type: journal_article volume: 166 year: '2004' ... --- _id: '3616' author: - first_name: Nicholas H full_name: Nicholas Barton id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: 'Barton NH. Speciation: Why, how, where and when? Current Biology. 2004;14(15):R603-R604. doi:10.1016/j.cub.2004.07.037' apa: 'Barton, N. H. (2004). Speciation: Why, how, where and when? Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2004.07.037' chicago: 'Barton, Nicholas H. “Speciation: Why, How, Where and When?” Current Biology. Cell Press, 2004. https://doi.org/10.1016/j.cub.2004.07.037.' ieee: 'N. H. Barton, “Speciation: Why, how, where and when?,” Current Biology, vol. 14, no. 15. Cell Press, pp. R603–R604, 2004.' ista: 'Barton NH. 2004. Speciation: Why, how, where and when? Current Biology. 14(15), R603–R604.' mla: 'Barton, Nicholas H. “Speciation: Why, How, Where and When?” Current Biology, vol. 14, no. 15, Cell Press, 2004, pp. R603–04, doi:10.1016/j.cub.2004.07.037.' short: N.H. Barton, Current Biology 14 (2004) R603–R604. date_created: 2018-12-11T12:04:16Z date_published: 2004-08-10T00:00:00Z date_updated: 2019-04-26T07:22:31Z day: '10' doi: 10.1016/j.cub.2004.07.037 extern: 1 intvolume: ' 14' issue: '15' month: '08' page: R603 - R604 publication: Current Biology publication_status: published publisher: Cell Press publist_id: '2767' quality_controlled: 0 status: public title: 'Speciation: Why, how, where and when?' type: review volume: 14 year: '2004' ... --- _id: '3688' abstract: - lang: eng text: Capturing images of documents using handheld digital cameras has a variety of applications in academia, research, knowledge management, retail, and office settings. The ultimate goal of such systems is to achieve image quality comparable to that currently achieved with flatbed scanners even for curved, warped, or curled pages. This can be achieved by high-accuracy 3D modeling of the page surface, followed by a "flattening" of the surface. A number of previous systems have either assumed only perspective distortions, or used techniques like structured lighting, shading, or side-imaging for obtaining 3D shape. This paper describes a system for handheld camera-based document capture using general purpose stereo vision methods followed by a new document dewarping technique. Examples of shape modeling and dewarping of book images is shown. author: - first_name: Adrian full_name: Ulges, Adrian last_name: Ulges - first_name: Christoph full_name: Christoph Lampert id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 - first_name: Thomas full_name: Breuel,Thomas M last_name: Breuel citation: ama: 'Ulges A, Lampert C, Breuel T. Document capture using stereo vision. In: ACM; 2004:198-200. doi:10.1145/1030397.1030434' apa: 'Ulges, A., Lampert, C., & Breuel, T. (2004). Document capture using stereo vision (pp. 198–200). Presented at the DocEng: ACM Symposium on Document Engineering, ACM. https://doi.org/10.1145/1030397.1030434' chicago: Ulges, Adrian, Christoph Lampert, and Thomas Breuel. “Document Capture Using Stereo Vision,” 198–200. ACM, 2004. https://doi.org/10.1145/1030397.1030434. ieee: 'A. Ulges, C. Lampert, and T. Breuel, “Document capture using stereo vision,” presented at the DocEng: ACM Symposium on Document Engineering, 2004, pp. 198–200.' ista: 'Ulges A, Lampert C, Breuel T. 2004. Document capture using stereo vision. DocEng: ACM Symposium on Document Engineering, 198–200.' mla: Ulges, Adrian, et al. Document Capture Using Stereo Vision. ACM, 2004, pp. 198–200, doi:10.1145/1030397.1030434. short: A. Ulges, C. Lampert, T. Breuel, in:, ACM, 2004, pp. 198–200. conference: name: 'DocEng: ACM Symposium on Document Engineering' date_created: 2018-12-11T12:04:38Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T07:48:58Z day: '01' doi: 10.1145/1030397.1030434 extern: 1 main_file_link: - open_access: '0' url: http://pub.ist.ac.at/~chl/papers/ulges-doceng2004.pdf month: '01' page: 198 - 200 publication_status: published publisher: ACM publist_id: '2679' quality_controlled: 0 status: public title: Document capture using stereo vision type: conference year: '2004' ... --- _id: '3810' abstract: - lang: eng text: Voltage-gated potassium (Kv) channels control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells. It is thought that the combinatorial association between distinct alpha and beta subunits determines whether Kv channels function as non-inactivating delayed rectifiers or as rapidly inactivating A-type channels. We show that membrane lipids can convert A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove N-type inactivation from A-type channels by immobilizing the inactivation domains. Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers with rapid voltage-dependent inactivation. The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system. author: - first_name: Dominik full_name: Oliver, Dominik last_name: Oliver - first_name: Cheng full_name: Lien, Cheng-Chang last_name: Lien - first_name: Malle full_name: Soom, Malle last_name: Soom - first_name: Thomas full_name: Baukrowitz, Thomas last_name: Baukrowitz - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Bernd full_name: Fakler, Bernd last_name: Fakler citation: ama: Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 2004;304(5668):265-270. doi:10.1126/science.1094113 apa: Oliver, D., Lien, C., Soom, M., Baukrowitz, T., Jonas, P. M., & Fakler, B. (2004). Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1094113 chicago: Oliver, Dominik, Cheng Lien, Malle Soom, Thomas Baukrowitz, Peter M Jonas, and Bernd Fakler. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” Science. American Association for the Advancement of Science, 2004. https://doi.org/10.1126/science.1094113. ieee: D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P. M. Jonas, and B. Fakler, “Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids,” Science, vol. 304, no. 5668. American Association for the Advancement of Science, pp. 265–70, 2004. ista: Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. 2004. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 304(5668), 265–70. mla: Oliver, Dominik, et al. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” Science, vol. 304, no. 5668, American Association for the Advancement of Science, 2004, pp. 265–70, doi:10.1126/science.1094113. short: D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P.M. Jonas, B. Fakler, Science 304 (2004) 265–70. date_created: 2018-12-11T12:05:18Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T07:52:22Z day: '01' doi: 10.1126/science.1094113 extern: 1 intvolume: ' 304' issue: '5668' month: '01' page: 265 - 70 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '2402' quality_controlled: 0 status: public title: Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids type: journal_article volume: 304 year: '2004' ... --- _id: '3894' abstract: - lang: eng text: We study infinite stochastic games played by n-players on a finite graph with goals given by sets of infinite traces. The games are stochastic (each player simultaneously and independently chooses an action at each round, and the next state is determined by a probability distribution depending on the current state and the chosen actions), infinite (the game continues for an infinite number of rounds), nonzero sum (the players' goals are not necessarily conflicting), and undiscounted. We show that if each player has a reachability objective, that is, if the goal for each player i is to visit some subset R-i of the states, then there exists an epsilon-Nash equilibrium in memoryless strategies, for every epsilon > 0. However, exact Nash equilibria need not exist. We study the complexity of finding such Nash equilibria, and show that the payoff of some epsilon-Nash equilibrium in memoryless strategies can be epsilon-approximated in NP. We study the important subclass of n-player turn-based probabilistic games, where at each state at most one player has a nontrivial choice of moves. For turn-based probabilistic games, we show the existence of epsilon-Nash equilibria in pure strategies for games where the objective of player i is a Borel set B-i of infinite traces. However, exact Nash equilibria may not exist. For the special case of omega-regular objectives, we show exact Nash equilibria exist, and can be computed in NP when the omega-regular objectives are expressed as parity objectives. acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327, ONR grant N00014-02-1-0671, NSF grants CCR-9988172 and CCR-0225610 alternative_title: - 'LNCS ' author: - first_name: Krishnendu full_name: Krishnendu Chatterjee id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Ritankar full_name: Majumdar, Ritankar S last_name: Majumdar - first_name: Marcin full_name: Jurdziński, Marcin last_name: Jurdziński citation: ama: 'Chatterjee K, Majumdar R, Jurdziński M. On Nash equilibria in stochastic games. In: Vol 3210. Springer; 2004:26-40. doi:10.1007/978-3-540-30124-0_6' apa: 'Chatterjee, K., Majumdar, R., & Jurdziński, M. (2004). On Nash equilibria in stochastic games (Vol. 3210, pp. 26–40). Presented at the CSL: Computer Science Logic, Springer. https://doi.org/10.1007/978-3-540-30124-0_6' chicago: Chatterjee, Krishnendu, Ritankar Majumdar, and Marcin Jurdziński. “On Nash Equilibria in Stochastic Games,” 3210:26–40. Springer, 2004. https://doi.org/10.1007/978-3-540-30124-0_6. ieee: 'K. Chatterjee, R. Majumdar, and M. Jurdziński, “On Nash equilibria in stochastic games,” presented at the CSL: Computer Science Logic, 2004, vol. 3210, pp. 26–40.' ista: 'Chatterjee K, Majumdar R, Jurdziński M. 2004. On Nash equilibria in stochastic games. CSL: Computer Science Logic, LNCS , vol. 3210, 26–40.' mla: Chatterjee, Krishnendu, et al. On Nash Equilibria in Stochastic Games. Vol. 3210, Springer, 2004, pp. 26–40, doi:10.1007/978-3-540-30124-0_6. short: K. Chatterjee, R. Majumdar, M. Jurdziński, in:, Springer, 2004, pp. 26–40. conference: name: 'CSL: Computer Science Logic' date_created: 2018-12-11T12:05:45Z date_published: 2004-09-09T00:00:00Z date_updated: 2021-01-12T07:53:01Z day: '09' doi: 10.1007/978-3-540-30124-0_6 extern: 1 intvolume: ' 3210' month: '09' page: 26 - 40 publication_status: published publisher: Springer publist_id: '2264' quality_controlled: 0 status: public title: On Nash equilibria in stochastic games type: conference volume: 3210 year: '2004' ... --- _id: '3895' abstract: - lang: eng text: 'In 2-player non-zero-sum games, Nash equilibria capture the options for rational behavior if each player attempts to maximize her payoff. In contrast to classical game theory, we consider lexicographic objectives: first, each player tries to maximize her own payoff, and then, the player tries to minimize the opponent''s payoff. Such objectives arise naturally in the verification of systems with multiple components. There, instead of proving that each component satisfies its specification no matter how the other components behave, it often suffices to prove that each component satisfies its specification provided that the other components satisfy their specifications. We say that a Nash equilibrium is secure if it is an equilibrium with respect to the lexicographic objectives of both players. We prove that in graph games with Borel objectives, which include the games that arise in verification, there may be several Nash equilibria, but there is always a unique maximal payoff profile of secure equilibria. We show how this equilibrium can be computed in the case of omega-regular objectives, and we characterize the memory requirements of strategies that achieve the equilibrium.' author: - first_name: Krishnendu full_name: Krishnendu Chatterjee id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Thomas A full_name: Thomas Henzinger id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Marcin full_name: Jurdziński, Marcin last_name: Jurdziński citation: ama: 'Chatterjee K, Henzinger TA, Jurdziński M. Games with secure equilibria. In: IEEE; 2004:160-169. doi:10.1109/LICS.2004.1319610' apa: 'Chatterjee, K., Henzinger, T. A., & Jurdziński, M. (2004). Games with secure equilibria (pp. 160–169). Presented at the LICS: Logic in Computer Science, IEEE. https://doi.org/10.1109/LICS.2004.1319610' chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Marcin Jurdziński. “Games with Secure Equilibria,” 160–69. IEEE, 2004. https://doi.org/10.1109/LICS.2004.1319610. ieee: 'K. Chatterjee, T. A. Henzinger, and M. Jurdziński, “Games with secure equilibria,” presented at the LICS: Logic in Computer Science, 2004, pp. 160–169.' ista: 'Chatterjee K, Henzinger TA, Jurdziński M. 2004. Games with secure equilibria. LICS: Logic in Computer Science, 160–169.' mla: Chatterjee, Krishnendu, et al. Games with Secure Equilibria. IEEE, 2004, pp. 160–69, doi:10.1109/LICS.2004.1319610. short: K. Chatterjee, T.A. Henzinger, M. Jurdziński, in:, IEEE, 2004, pp. 160–169. conference: name: 'LICS: Logic in Computer Science' date_created: 2018-12-11T12:05:45Z date_published: 2004-08-09T00:00:00Z date_updated: 2021-01-12T07:53:01Z day: '09' doi: 10.1109/LICS.2004.1319610 extern: 1 month: '08' page: 160 - 169 publication_status: published publisher: IEEE publist_id: '2262' quality_controlled: 0 status: public title: Games with secure equilibria type: conference year: '2004' ... --- _id: '3931' abstract: - lang: eng text: Hyaluronan is an unsulfated glycosaminoglycan (GAG) that is ubiquitously expressed in the extracellular matrix (ECM) of all vertebrates, where hyaluronan rich matrices constitute a particular permissive environment for the development of complex biological structures and also for tumor progression. Because of its conserved structure and ubiquitous expression, antibodies for its histochemical detection cannot be produced. We have engineered a fusion protein, neurocan-GFP, and expressed it as a secreted molecule in mammalian cells. Neurocan-GFP fusion protein specifically binds to hyaluronan and directly visualizes hyaluronan on tissue sections, revealing a very detailed picture of hyaluronan distribution. The fluorescent fusion protein can be used in combination with antibodies and nuclear markers for double or triple staining. In addition, it is suitable to visualize hyaluronan on living cells by time-lapse video microscopy. The successful production and application of the neurocan-GFP fusion protein opens up new perspectives for using GFP fusion proteins as detection tools in histological and cytological studies complementing conventional antibody and biotin/avidin techniques. author: - first_name: Hui full_name: Zhang, Hui last_name: Zhang - first_name: Stephan full_name: Baader, Stephan L last_name: Baader - first_name: Michael K full_name: Michael Sixt id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Joachim full_name: Kappler, Joachim last_name: Kappler - first_name: Uwe full_name: Rauch, Uwe last_name: Rauch citation: ama: 'Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. Journal of Histochemistry and Cytochemistry. 2004;52(7):915-922. doi:10.1369/jhc.3A6221.2004' apa: 'Zhang, H., Baader, S., Sixt, M. K., Kappler, J., & Rauch, U. (2004). Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. Journal of Histochemistry and Cytochemistry. Histochemical Society. https://doi.org/10.1369/jhc.3A6221.2004' chicago: 'Zhang, Hui, Stephan Baader, Michael K Sixt, Joachim Kappler, and Uwe Rauch. “Neurocan-GFP Fusion Protein: A New Approach to Detect Hyaluronan on Tissue Sections and Living Cells.” Journal of Histochemistry and Cytochemistry. Histochemical Society, 2004. https://doi.org/10.1369/jhc.3A6221.2004.' ieee: 'H. Zhang, S. Baader, M. K. Sixt, J. Kappler, and U. Rauch, “Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells,” Journal of Histochemistry and Cytochemistry, vol. 52, no. 7. Histochemical Society, pp. 915–922, 2004.' ista: 'Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. 2004. Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells. Journal of Histochemistry and Cytochemistry. 52(7), 915–922.' mla: 'Zhang, Hui, et al. “Neurocan-GFP Fusion Protein: A New Approach to Detect Hyaluronan on Tissue Sections and Living Cells.” Journal of Histochemistry and Cytochemistry, vol. 52, no. 7, Histochemical Society, 2004, pp. 915–22, doi:10.1369/jhc.3A6221.2004.' short: H. Zhang, S. Baader, M.K. Sixt, J. Kappler, U. Rauch, Journal of Histochemistry and Cytochemistry 52 (2004) 915–922. date_created: 2018-12-11T12:05:57Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T07:53:17Z day: '01' doi: 10.1369/jhc.3A6221.2004 extern: 1 intvolume: ' 52' issue: '7' month: '01' page: 915 - 922 publication: Journal of Histochemistry and Cytochemistry publication_status: published publisher: Histochemical Society publist_id: '2196' quality_controlled: 0 status: public title: 'Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue sections and living cells' type: journal_article volume: 52 year: '2004' ... --- _id: '3929' abstract: - lang: eng text: The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to interfere with T cell activation signals by forming a signaling complex at the plasma membrane. Composition and function of the complex are not fully understood. Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far known as a nuclear factor and repressor of transcription, to the membrane of cells. The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent HIV transcription, implying that Eed removal from the nucleus is required for optimal Tat function. Similar to Nef action, activation of integrin receptors recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated transcription. Our results suggest a link between membrane-associated activation processes and transcriptional derepression and demonstrate how HIV exploits this mechanism. author: - first_name: Vanessa full_name: Witte, Vanessa last_name: Witte - first_name: Bernd full_name: Laffert, Bernd last_name: Laffert - first_name: Olaf full_name: Rosorius, Olaf last_name: Rosorius - first_name: Peter full_name: Lischka, Peter last_name: Lischka - first_name: Katja full_name: Blume, Katja last_name: Blume - first_name: Gunther full_name: Galler, Gunther last_name: Galler - first_name: Andrea full_name: Stilper, Andrea last_name: Stilper - first_name: Dieter full_name: Willbold, Dieter last_name: Willbold - first_name: Paola full_name: D'Aloja, Paola last_name: D'Aloja - first_name: Michael K full_name: Michael Sixt id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Johanna full_name: Kolanus, Johanna last_name: Kolanus - first_name: Melanie full_name: Ott, Melanie last_name: Ott - first_name: Waldemar full_name: Kolanus, Waldemar last_name: Kolanus - first_name: Gerold full_name: Schuler, Gerold last_name: Schuler - first_name: Andreas full_name: Baur, Andreas S last_name: Baur citation: ama: Witte V, Laffert B, Rosorius O, et al. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Molecular Cell. 2004;13(2):179-190. doi:10.1016/S1097-2765(04)00004-8 apa: Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., … Baur, A. (2004). HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Molecular Cell. Cell Press. https://doi.org/10.1016/S1097-2765(04)00004-8 chicago: Witte, Vanessa, Bernd Laffert, Olaf Rosorius, Peter Lischka, Katja Blume, Gunther Galler, Andrea Stilper, et al. “HIV-1 Nef Mimics an Integrin Receptor Signal That Recruits the Polycomb Group Protein Eed to the Plasma Membrane.” Molecular Cell. Cell Press, 2004. https://doi.org/10.1016/S1097-2765(04)00004-8. ieee: V. Witte et al., “HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane,” Molecular Cell, vol. 13, no. 2. Cell Press, pp. 179–190, 2004. ista: Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D’Aloja P, Sixt MK, Kolanus J, Ott M, Kolanus W, Schuler G, Baur A. 2004. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Molecular Cell. 13(2), 179–190. mla: Witte, Vanessa, et al. “HIV-1 Nef Mimics an Integrin Receptor Signal That Recruits the Polycomb Group Protein Eed to the Plasma Membrane.” Molecular Cell, vol. 13, no. 2, Cell Press, 2004, pp. 179–90, doi:10.1016/S1097-2765(04)00004-8. short: V. Witte, B. Laffert, O. Rosorius, P. Lischka, K. Blume, G. Galler, A. Stilper, D. Willbold, P. D’Aloja, M.K. Sixt, J. Kolanus, M. Ott, W. Kolanus, G. Schuler, A. Baur, Molecular Cell 13 (2004) 179–190. date_created: 2018-12-11T12:05:56Z date_published: 2004-01-30T00:00:00Z date_updated: 2021-01-12T07:53:16Z day: '30' doi: 10.1016/S1097-2765(04)00004-8 extern: 1 intvolume: ' 13' issue: '2' month: '01' page: 179 - 190 publication: Molecular Cell publication_status: published publisher: Cell Press publist_id: '2197' quality_controlled: 0 status: public title: HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane type: journal_article volume: 13 year: '2004' ... --- _id: '3990' abstract: - lang: eng text: The writhing number measures the global geometry of a closed space curve or knot. We show that this measure is related to the average winding number of its Gauss map. Using this relationship, we give an algorithm for computing the writhing number for a polygonal knot with n edges in time roughly proportional to n(1.6). We also implement a different, simple algorithm and provide experimental evidence for its practical efficiency. acknowledgement: Partially supported by NSF under grants CCR-00-86013, EIA-9972879 and NSF under grant CCR-97-12088. author: - first_name: Pankaj full_name: Agarwal, Pankaj K last_name: Agarwal - first_name: Herbert full_name: Herbert Edelsbrunner id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Yusu full_name: Wang, Yusu last_name: Wang citation: ama: Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal knot. Discrete & Computational Geometry. 2004;32(1):37-53. doi:10.1007/s00454-004-2864-x apa: Agarwal, P., Edelsbrunner, H., & Wang, Y. (2004). Computing the writhing number of a polygonal knot. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-004-2864-x chicago: Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing Number of a Polygonal Knot.” Discrete & Computational Geometry. Springer, 2004. https://doi.org/10.1007/s00454-004-2864-x. ieee: P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of a polygonal knot,” Discrete & Computational Geometry, vol. 32, no. 1. Springer, pp. 37–53, 2004. ista: Agarwal P, Edelsbrunner H, Wang Y. 2004. Computing the writhing number of a polygonal knot. Discrete & Computational Geometry. 32(1), 37–53. mla: Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.” Discrete & Computational Geometry, vol. 32, no. 1, Springer, 2004, pp. 37–53, doi:10.1007/s00454-004-2864-x. short: P. Agarwal, H. Edelsbrunner, Y. Wang, Discrete & Computational Geometry 32 (2004) 37–53. date_created: 2018-12-11T12:06:18Z date_published: 2004-05-01T00:00:00Z date_updated: 2021-01-12T07:53:42Z day: '01' doi: 10.1007/s00454-004-2864-x extern: 1 intvolume: ' 32' issue: '1' month: '05' page: 37 - 53 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '2138' quality_controlled: 0 status: public title: Computing the writhing number of a polygonal knot type: journal_article volume: 32 year: '2004' ... --- _id: '4224' abstract: - lang: eng text: Developing cells acquire positional information by reading the graded distribution of morphogens. In Drosophila, the Dpp morphogen forms a long-range concentration gradient by spreading from a restricted source in the developing wing. It has been assumed that Dpp spreads by extracellular diffusion. Under this assumption, the main role of endocytosis in gradient formation is to downregulate receptors at the cell surface. These surface receptors bind to the ligand and thereby interfere with its long-range movement. Recent experiments indicate that Dpp spreading is mediated by Dynamin-dependent endocytosis in the target tissue, suggesting that extracellular diffusion alone cannot account for Dpp dispersal. Here, we perform a theoretical study of a model for morphogen spreading based on extracellular diffusion, which takes into account receptor binding and trafficking. We compare profiles of ligand and surface receptors obtained in this model with experimental data. To this end, we monitored directly the pool of surface receptors and extracellular Dpp with specific antibodies. We conclude that current models considering pure extracellular diffusion cannot explain the observed role of endocytosis during Dpp long-range movement. article_processing_charge: No author: - first_name: Karsten full_name: Kruse, Karsten last_name: Kruse - first_name: Periklis full_name: Pantazis, Periklis last_name: Pantazis - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X - first_name: Frank full_name: Julicher, Frank last_name: Julicher - first_name: Marcos full_name: Gonzalez Gaitan, Marcos last_name: Gonzalez Gaitan citation: ama: 'Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development. 2004;131(19):4843-4856. doi:10.1242/dev.01335' apa: 'Kruse, K., Pantazis, P., Bollenbach, M. T., Julicher, F., & Gonzalez Gaitan, M. (2004). Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development. Company of Biologists. https://doi.org/10.1242/dev.01335' chicago: 'Kruse, Karsten, Periklis Pantazis, Mark Tobias Bollenbach, Frank Julicher, and Marcos Gonzalez Gaitan. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” Development. Company of Biologists, 2004. https://doi.org/10.1242/dev.01335.' ieee: 'K. Kruse, P. Pantazis, M. T. Bollenbach, F. Julicher, and M. Gonzalez Gaitan, “Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model,” Development, vol. 131, no. 19. Company of Biologists, pp. 4843–4856, 2004.' ista: 'Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. 2004. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development. 131(19), 4843–4856.' mla: 'Kruse, Karsten, et al. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” Development, vol. 131, no. 19, Company of Biologists, 2004, pp. 4843–56, doi:10.1242/dev.01335.' short: K. Kruse, P. Pantazis, M.T. Bollenbach, F. Julicher, M. Gonzalez Gaitan, Development 131 (2004) 4843–4856. date_created: 2018-12-11T12:07:41Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T07:55:26Z day: '01' doi: 10.1242/dev.01335 extern: '1' intvolume: ' 131' issue: '19' language: - iso: eng month: '01' oa_version: None page: 4843 - 4856 publication: Development publication_status: published publisher: Company of Biologists publist_id: '1893' status: public title: 'Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 131 year: '2004' ... --- _id: '4239' alternative_title: - Cellular Origin, Life in Extreme Habitats and Astrobiology author: - first_name: Harold full_name: Harold Vladar id: 2A181218-F248-11E8-B48F-1D18A9856A87 last_name: Vladar orcid: 0000-0002-5985-7653 - first_name: Roberto full_name: 'Cipriani, Roberto ' last_name: Cipriani - first_name: Benjamin full_name: Scharifker, Benjamin last_name: Scharifker - first_name: Jose full_name: Bubis, Jose last_name: Bubis citation: ama: 'de Vladar H, Cipriani R, Scharifker B, Bubis J. A Mechanism for the Prebiotic Emergence of Proteins. In: Seckbach J, Chela Flores J, Owen T, Raulin F, eds. Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds. Vol 7. Springer; 2004:83-87. doi:3807' apa: de Vladar, H., Cipriani, R., Scharifker, B., & Bubis, J. (2004). A Mechanism for the Prebiotic Emergence of Proteins. In J. Seckbach, J. Chela Flores, T. Owen, & F. Raulin (Eds.), Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds (Vol. 7, pp. 83–87). Springer. https://doi.org/3807 chicago: Vladar, Harold de, Roberto Cipriani, Benjamin Scharifker, and Jose Bubis. “A Mechanism for the Prebiotic Emergence of Proteins.” In Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, edited by J. Seckbach, J. Chela Flores, T. Owen, and F. Raulin, 7:83–87. Springer, 2004. https://doi.org/3807. ieee: H. de Vladar, R. Cipriani, B. Scharifker, and J. Bubis, “A Mechanism for the Prebiotic Emergence of Proteins,” in Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, vol. 7, J. Seckbach, J. Chela Flores, T. Owen, and F. Raulin, Eds. Springer, 2004, pp. 83–87. ista: 'de Vladar H, Cipriani R, Scharifker B, Bubis J. 2004.A Mechanism for the Prebiotic Emergence of Proteins. In: Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol. 7, 83–87.' mla: de Vladar, Harold, et al. “A Mechanism for the Prebiotic Emergence of Proteins.” Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, edited by J. Seckbach et al., vol. 7, Springer, 2004, pp. 83–87, doi:3807. short: H. de Vladar, R. Cipriani, B. Scharifker, J. Bubis, in:, J. Seckbach, J. Chela Flores, T. Owen, F. Raulin (Eds.), Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds, Springer, 2004, pp. 83–87. date_created: 2018-12-11T12:07:47Z date_published: 2004-01-01T00:00:00Z date_updated: 2021-01-12T07:55:32Z day: '01' doi: '3807' editor: - first_name: J. full_name: Seckbach,J. last_name: Seckbach - first_name: J. full_name: Chela-Flores,J. last_name: Chela Flores - first_name: T. full_name: Owen,T. last_name: Owen - first_name: F. full_name: Raulin,F. last_name: Raulin extern: 1 intvolume: ' 7' month: '01' page: 83 - 87 publication: Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds publication_status: published publisher: Springer publist_id: '1875' quality_controlled: 0 status: public title: A Mechanism for the Prebiotic Emergence of Proteins type: book_chapter volume: 7 year: '2004' ...