--- _id: '2358' abstract: - lang: eng text: A study was conducted on the one-dimensional (1D) bosons in three-dimensional (3D) traps. A rigorous analysis was carried out on the parameter regions in which various types of 1D or 3D behavior occurred in the ground state. The four parameter regions include density, transverse, longitudinal dimensions and scattering length. author: - first_name: Élliott full_name: Lieb, Élliott H last_name: Lieb - first_name: Robert full_name: Robert Seiringer id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: Lieb É, Seiringer R, Yngvason J. One-dimensional Bosons in three-dimensional traps. Physical Review Letters. 2003;91(15):1504011-1504014. doi:10.1103/PhysRevLett.91.150401 apa: Lieb, É., Seiringer, R., & Yngvason, J. (2003). One-dimensional Bosons in three-dimensional traps. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.91.150401 chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “One-Dimensional Bosons in Three-Dimensional Traps.” Physical Review Letters. American Physical Society, 2003. https://doi.org/10.1103/PhysRevLett.91.150401. ieee: É. Lieb, R. Seiringer, and J. Yngvason, “One-dimensional Bosons in three-dimensional traps,” Physical Review Letters, vol. 91, no. 15. American Physical Society, pp. 1504011–1504014, 2003. ista: Lieb É, Seiringer R, Yngvason J. 2003. One-dimensional Bosons in three-dimensional traps. Physical Review Letters. 91(15), 1504011–1504014. mla: Lieb, Élliott, et al. “One-Dimensional Bosons in Three-Dimensional Traps.” Physical Review Letters, vol. 91, no. 15, American Physical Society, 2003, pp. 1504011–14, doi:10.1103/PhysRevLett.91.150401. short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review Letters 91 (2003) 1504011–1504014. date_created: 2018-12-11T11:57:12Z date_published: 2003-10-10T00:00:00Z date_updated: 2021-01-12T06:57:00Z day: '10' doi: 10.1103/PhysRevLett.91.150401 extern: 1 intvolume: ' 91' issue: '15' main_file_link: - open_access: '1' url: http://arxiv.org/abs/cond-mat/0304071 month: '10' oa: 1 page: 1504011 - 1504014 publication: Physical Review Letters publication_status: published publisher: American Physical Society publist_id: '4571' quality_controlled: 0 status: public title: One-dimensional Bosons in three-dimensional traps type: journal_article volume: 91 year: '2003' ... --- _id: '2414' author: - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: Wagner U. On k-Sets and Their Applications. 2003. doi:10.3929/ethz-a-004708408 apa: Wagner, U. (2003). On k-Sets and Their Applications. ETH Zurich. https://doi.org/10.3929/ethz-a-004708408 chicago: Wagner, Uli. “On K-Sets and Their Applications.” ETH Zurich, 2003. https://doi.org/10.3929/ethz-a-004708408. ieee: U. Wagner, “On k-Sets and Their Applications,” ETH Zurich, 2003. ista: Wagner U. 2003. On k-Sets and Their Applications. ETH Zurich. mla: Wagner, Uli. On K-Sets and Their Applications. ETH Zurich, 2003, doi:10.3929/ethz-a-004708408. short: U. Wagner, On K-Sets and Their Applications, ETH Zurich, 2003. date_created: 2018-12-11T11:57:31Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T06:57:20Z day: '01' doi: 10.3929/ethz-a-004708408 extern: 1 month: '01' publication_status: published publisher: ETH Zurich publist_id: '4511' quality_controlled: 0 status: public title: On k-Sets and Their Applications type: dissertation year: '2003' ... --- _id: '2424' abstract: - lang: eng text: We introduce the adaptive neighborhood graph as a data structure for modeling a smooth manifold M embedded in some (potentially very high-dimensional) Euclidean space ℝd. We assume that M is known to us only through a finite sample P ⊂ M, as it is often the case in applications. The adaptive neighborhood graph is a geometric graph on P. Its complexity is at most min{2O(k)(n, n2}, where n = |P| and k = dim M, as opposed to the n⌈d/2⌉ complexity of the Delaunay triangulation, which is often used to model manifolds. We show that we can provably correctly infer the connectivity of M and the dimension of M from the adaptive neighborhood graph provided a certain standard sampling condition is fulfilled. The running time of the dimension detection algorithm is d2O(k7 log k) for each connected component of M. If the dimension is considered constant, this is a constant-time operation, and the adaptive neighborhood graph is of linear size. Moreover, the exponential dependence of the constants is only on the intrinsic dimension k, not on the ambient dimension d. This is of particular interest if the co-dimension is high, i.e., if k is much smaller than d, as is the case in many applications. The adaptive neighborhood graph also allows us to approximate the geodesic distances between the points in P. author: - first_name: Joachim full_name: Giesen, Joachim last_name: Giesen - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: 'Giesen J, Wagner U. Shape dimension and intrinsic metric from samples of manifolds with high co-dimension. In: ACM; 2003:329-337. doi:10.1145/777792.777841' apa: 'Giesen, J., & Wagner, U. (2003). Shape dimension and intrinsic metric from samples of manifolds with high co-dimension (pp. 329–337). Presented at the SoCG: Symposium on Computational Geometry, ACM. https://doi.org/10.1145/777792.777841' chicago: Giesen, Joachim, and Uli Wagner. “Shape Dimension and Intrinsic Metric from Samples of Manifolds with High Co-Dimension,” 329–37. ACM, 2003. https://doi.org/10.1145/777792.777841. ieee: 'J. Giesen and U. Wagner, “Shape dimension and intrinsic metric from samples of manifolds with high co-dimension,” presented at the SoCG: Symposium on Computational Geometry, 2003, pp. 329–337.' ista: 'Giesen J, Wagner U. 2003. Shape dimension and intrinsic metric from samples of manifolds with high co-dimension. SoCG: Symposium on Computational Geometry, 329–337.' mla: Giesen, Joachim, and Uli Wagner. Shape Dimension and Intrinsic Metric from Samples of Manifolds with High Co-Dimension. ACM, 2003, pp. 329–37, doi:10.1145/777792.777841. short: J. Giesen, U. Wagner, in:, ACM, 2003, pp. 329–337. conference: name: 'SoCG: Symposium on Computational Geometry' date_created: 2018-12-11T11:57:35Z date_published: 2003-06-01T00:00:00Z date_updated: 2021-01-12T06:57:24Z day: '01' doi: 10.1145/777792.777841 extern: 1 month: '06' page: 329 - 337 publication_status: published publisher: ACM publist_id: '4501' quality_controlled: 0 status: public title: Shape dimension and intrinsic metric from samples of manifolds with high co-dimension type: conference year: '2003' ... --- _id: '2423' abstract: - lang: eng text: A finite set N ⊃ Rd is a weak ε-net for an n-point set X ⊃ Rd (with respect to convex sets) if N intersects every convex set K with |K ∩ X| ≥ εn. We give an alternative, and arguably simpler, proof of the fact, first shown by Chazelle et al. [7], that every point set X in Rd admits a weak ε-net of cardinality O(ε-d polylog(1/ε)). Moreover, for a number of special point sets (e.g., for points on the moment curve), our method gives substantially better bounds. The construction yields an algorithm to construct such weak ε-nets in time O(n ln(1/ε)). We also prove, by a different method, a near-linear upper bound for points uniformly distributed on the (d - 1)-dimensional sphere. author: - first_name: Jiří full_name: Matoušek, Jiří last_name: Matoušek - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: 'Matoušek J, Wagner U. New constructions of weak epsilon-nets. In: ACM; 2003:129-135. doi:10.1145/777792.777813' apa: 'Matoušek, J., & Wagner, U. (2003). New constructions of weak epsilon-nets (pp. 129–135). Presented at the SoCG: Symposium on Computational Geometry, ACM. https://doi.org/10.1145/777792.777813' chicago: Matoušek, Jiří, and Uli Wagner. “New Constructions of Weak Epsilon-Nets,” 129–35. ACM, 2003. https://doi.org/10.1145/777792.777813. ieee: 'J. Matoušek and U. Wagner, “New constructions of weak epsilon-nets,” presented at the SoCG: Symposium on Computational Geometry, 2003, pp. 129–135.' ista: 'Matoušek J, Wagner U. 2003. New constructions of weak epsilon-nets. SoCG: Symposium on Computational Geometry, 129–135.' mla: Matoušek, Jiří, and Uli Wagner. New Constructions of Weak Epsilon-Nets. ACM, 2003, pp. 129–35, doi:10.1145/777792.777813. short: J. Matoušek, U. Wagner, in:, ACM, 2003, pp. 129–135. conference: name: 'SoCG: Symposium on Computational Geometry' date_created: 2018-12-11T11:57:34Z date_published: 2003-06-01T00:00:00Z date_updated: 2021-01-12T06:57:24Z day: '01' doi: 10.1145/777792.777813 extern: 1 month: '06' page: 129 - 135 publication_status: published publisher: ACM publist_id: '4502' quality_controlled: 0 status: public title: New constructions of weak epsilon-nets type: conference year: '2003' ... --- _id: '2422' abstract: - lang: eng text: We prove a lower bound of 0.3288(4 n) for the rectilinear crossing number cr̄(Kn) of a complete graph on n vertices, or in other words, for the minimum number of convex quadrilaterals in any set of n points in general position in the Euclidean plane. As we see it, the main contribution of this paper is not so much the concrete numerical improvement over earlier bounds, as the novel method of proof, which is not based on bounding cr̄(Kn) for some small n. author: - first_name: Uli full_name: Uli Wagner id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 citation: ama: 'Wagner U. On the rectilinear crossing number of complete graphs. In: SIAM; 2003:583-588.' apa: 'Wagner, U. (2003). On the rectilinear crossing number of complete graphs (pp. 583–588). Presented at the SODA: Symposium on Discrete Algorithms, SIAM.' chicago: Wagner, Uli. “On the Rectilinear Crossing Number of Complete Graphs,” 583–88. SIAM, 2003. ieee: 'U. Wagner, “On the rectilinear crossing number of complete graphs,” presented at the SODA: Symposium on Discrete Algorithms, 2003, pp. 583–588.' ista: 'Wagner U. 2003. On the rectilinear crossing number of complete graphs. SODA: Symposium on Discrete Algorithms, 583–588.' mla: Wagner, Uli. On the Rectilinear Crossing Number of Complete Graphs. SIAM, 2003, pp. 583–88. short: U. Wagner, in:, SIAM, 2003, pp. 583–588. conference: name: 'SODA: Symposium on Discrete Algorithms' date_created: 2018-12-11T11:57:34Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T06:57:24Z day: '01' extern: 1 main_file_link: - open_access: '0' url: http://dl.acm.org/citation.cfm?id=644206 month: '01' page: 583 - 588 publication_status: published publisher: SIAM publist_id: '4503' quality_controlled: 0 status: public title: On the rectilinear crossing number of complete graphs type: conference year: '2003' ... --- _id: '2623' abstract: - lang: eng text: Patients with Hodgkin's disease can develop paraneoplastic cerebellar ataxia because of the generation of autoantibodies against mGluR1 (mGluR1-Abs). Yet, the pathophysiological mechanisms underlying their motor coordination deficits remain to be elucidated. Here, we show that application of IgG purified from the patients' serum to cerebellar slices of mice acutely reduces the basal activity of Purkinje cells, whereas application to the flocculus of mice in vivo evokes acute disturbances in the performance of their compensatory eye movements. In addition, the mGluR1-Abs block induction of long-term depression in cultured mouse Purkinje cells, whereas the cerebellar motor learning behavior of the patients is affected in that they show impaired adaptation of their saccadic eye movements. Finally, postmortem analysis of the cerebellum of a paraneoplastic cerebellar ataxia patient showed that the number of Purkinje cells was significantly reduced by approximately two thirds compared with three controls. We conclude that autoantibodies against mGluR1 can cause cerebellar motor coordination deficits caused by a combination of rapid effects on both acute and plastic responses of Purkinje cells and chronic degenerative effects. author: - first_name: Michiel full_name: Coesmans, Michiel P last_name: Coesmans - first_name: Peter full_name: Sillevis-Smitt, Peter A last_name: Sillevis Smitt - first_name: David full_name: Linden, David J last_name: Linden - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Tomoo full_name: Hirano, Tomoo last_name: Hirano - first_name: Yoshinori full_name: Yamakawa, Yoshinori last_name: Yamakawa - first_name: Adriaan full_name: Van Alphen, Adriaan M last_name: Van Alphen - first_name: Chongde full_name: Luo, Chongde last_name: Luo - first_name: Jos full_name: Van Der Geest, Jos N last_name: Van Der Geest - first_name: Johan full_name: Kros, Johan M last_name: Kros - first_name: Carlo full_name: Gaillard, Carlo A last_name: Gaillard - first_name: Maarten full_name: Frens, Maarten A last_name: Frens - first_name: Chris full_name: De Zeeuw, Chris I last_name: De Zeeuw citation: ama: Coesmans M, Sillevis Smitt P, Linden D, et al. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Annals of Neurology. 2003;53(3):325-336. doi:10.1002/ana.10451 apa: Coesmans, M., Sillevis Smitt, P., Linden, D., Shigemoto, R., Hirano, T., Yamakawa, Y., … De Zeeuw, C. (2003). Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Annals of Neurology. Wiley-Blackwell. https://doi.org/10.1002/ana.10451 chicago: Coesmans, Michiel, Peter Sillevis Smitt, David Linden, Ryuichi Shigemoto, Tomoo Hirano, Yoshinori Yamakawa, Adriaan Van Alphen, et al. “Mechanisms Underlying Cerebellar Motor Deficits Due to MGluR1-Autoantibodies.” Annals of Neurology. Wiley-Blackwell, 2003. https://doi.org/10.1002/ana.10451. ieee: M. Coesmans et al., “Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies,” Annals of Neurology, vol. 53, no. 3. Wiley-Blackwell, pp. 325–336, 2003. ista: Coesmans M, Sillevis Smitt P, Linden D, Shigemoto R, Hirano T, Yamakawa Y, Van Alphen A, Luo C, Van Der Geest J, Kros J, Gaillard C, Frens M, De Zeeuw C. 2003. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies. Annals of Neurology. 53(3), 325–336. mla: Coesmans, Michiel, et al. “Mechanisms Underlying Cerebellar Motor Deficits Due to MGluR1-Autoantibodies.” Annals of Neurology, vol. 53, no. 3, Wiley-Blackwell, 2003, pp. 325–36, doi:10.1002/ana.10451. short: M. Coesmans, P. Sillevis Smitt, D. Linden, R. Shigemoto, T. Hirano, Y. Yamakawa, A. Van Alphen, C. Luo, J. Van Der Geest, J. Kros, C. Gaillard, M. Frens, C. De Zeeuw, Annals of Neurology 53 (2003) 325–336. date_created: 2018-12-11T11:58:44Z date_published: 2003-03-01T00:00:00Z date_updated: 2021-01-12T06:58:39Z day: '01' doi: 10.1002/ana.10451 extern: 1 intvolume: ' 53' issue: '3' month: '03' page: 325 - 336 publication: Annals of Neurology publication_status: published publisher: Wiley-Blackwell publist_id: '4274' quality_controlled: 0 status: public title: Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies type: journal_article volume: 53 year: '2003' ... --- _id: '2625' abstract: - lang: eng text: Metabotropic glutamate receptor 1 (mGluR1) plays a crucial role in synaptic plasticity and motor learning in the cerebellum. We have studied activity-dependent changes in mGluR1 function in mouse cultured Purkinje neurons. Depolarizing stimulation potentiated Ca2+ and current responses to an mGluR1 agonist for several hours in the cultured Purkinje neurons. It also blocked internalization of mGluR1 and increased the number of mGluR1s on the cell membrane. We found that depolarization simultaneously increased transcription of Homer1a in Purkinje neurons. Homer1a inhibited internalization and increased cell-surface expression of mGluR1 when coexpressed in human embryonic kidney (HEK)-293 cells. Depolarization-induced Homer1a expression in Purkinje neurons was blocked by a mitogen-activated protein kinase (MAPK) inhibitor. Changes in internalization and mGluR1-mediated Ca2+ response were also blocked by inhibition of MAPK activity, suggesting that localization and activity of mGluR1 were regulated in the same signalling pathway as Homer1a expression. It is thus suggested that depolarization of the Purkinje neuron leads to the increment in mGluR1 responsiveness through MAPK activity and induction of Homer1a expression, which increases active mGluR1 on the cell surface by blocking internalization of mGluR1. author: - first_name: Itsunari full_name: Minami, Itsunari last_name: Minami - first_name: Mineko full_name: Kengaku, Mineko last_name: Kengaku - first_name: Sillevis full_name: Smitt, Sillevis P last_name: Smitt - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Tomoo full_name: Hirano, Tomoo last_name: Hirano citation: ama: Minami I, Kengaku M, Smitt S, Shigemoto R, Hirano T. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. European Journal of Neuroscience. 2003;17(5):1023-1032. doi:10.1046/j.1460-9568.2003.02499.x apa: Minami, I., Kengaku, M., Smitt, S., Shigemoto, R., & Hirano, T. (2003). Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2003.02499.x chicago: Minami, Itsunari, Mineko Kengaku, Sillevis Smitt, Ryuichi Shigemoto, and Tomoo Hirano. “Long-Term Potentiation of MGluR1 Activity by Depolarization-Induced Homer1a in Mouse Cerebellar Purkinje Neurons.” European Journal of Neuroscience. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1460-9568.2003.02499.x. ieee: I. Minami, M. Kengaku, S. Smitt, R. Shigemoto, and T. Hirano, “Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons,” European Journal of Neuroscience, vol. 17, no. 5. Wiley-Blackwell, pp. 1023–1032, 2003. ista: Minami I, Kengaku M, Smitt S, Shigemoto R, Hirano T. 2003. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. European Journal of Neuroscience. 17(5), 1023–1032. mla: Minami, Itsunari, et al. “Long-Term Potentiation of MGluR1 Activity by Depolarization-Induced Homer1a in Mouse Cerebellar Purkinje Neurons.” European Journal of Neuroscience, vol. 17, no. 5, Wiley-Blackwell, 2003, pp. 1023–32, doi:10.1046/j.1460-9568.2003.02499.x. short: I. Minami, M. Kengaku, S. Smitt, R. Shigemoto, T. Hirano, European Journal of Neuroscience 17 (2003) 1023–1032. date_created: 2018-12-11T11:58:44Z date_published: 2003-03-01T00:00:00Z date_updated: 2021-01-12T06:58:39Z day: '01' doi: 10.1046/j.1460-9568.2003.02499.x extern: 1 intvolume: ' 17' issue: '5' month: '03' page: 1023 - 1032 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4273' quality_controlled: 0 status: public title: Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons type: journal_article volume: 17 year: '2003' ... --- _id: '2626' abstract: - lang: eng text: The expression pattern of metabotropic glutamate receptor Iα (mGluR1α) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1α immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) where calbindin-D28k-containing dopaminergic neurons invulnerable to parkinsonian degeneration are specifically located. On the other hand, mGluR1α was strongly expressed in the ventral tier of the substantia nigra pars cornpacta (SNc-v). In monkeys treated with the parkinsonism-inducing drug, I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mGluR1α expression was decreased in dopaminergic neurons in the SNc-v that were spared its toxic action. These results suggest that mGluR1α expression may be involved at least partly in the vulnerability of dopaminergic neurons to parkinsonian insults. author: - first_name: Katsuyuki full_name: Kaneda, Katsuyuki last_name: Kaneda - first_name: Michiko full_name: Imanishi, Michiko last_name: Imanishi - first_name: Atsushi full_name: Nambu, Atsushi last_name: Nambu - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Masahiko full_name: Takada, Masahiko last_name: Takada citation: ama: Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. 2003;14(7):947-950. doi:10.1097/01.wnr.0000074344.81633.e4 apa: Kaneda, K., Imanishi, M., Nambu, A., Shigemoto, R., & Takada, M. (2003). Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. Lippincott, Williams & Wilkins. https://doi.org/10.1097/01.wnr.0000074344.81633.e4 chicago: Kaneda, Katsuyuki, Michiko Imanishi, Atsushi Nambu, Ryuichi Shigemoto, and Masahiko Takada. “Differential Expression Patterns of MGluR1α in Monkey Nigral Dopamine Neurons.” Neuroreport. Lippincott, Williams & Wilkins, 2003. https://doi.org/10.1097/01.wnr.0000074344.81633.e4. ieee: K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, and M. Takada, “Differential expression patterns of mGluR1α in monkey nigral dopamine neurons,” Neuroreport, vol. 14, no. 7. Lippincott, Williams & Wilkins, pp. 947–950, 2003. ista: Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. 2003. Differential expression patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. 14(7), 947–950. mla: Kaneda, Katsuyuki, et al. “Differential Expression Patterns of MGluR1α in Monkey Nigral Dopamine Neurons.” Neuroreport, vol. 14, no. 7, Lippincott, Williams & Wilkins, 2003, pp. 947–50, doi:10.1097/01.wnr.0000074344.81633.e4. short: K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, M. Takada, Neuroreport 14 (2003) 947–950. date_created: 2018-12-11T11:58:45Z date_published: 2003-05-01T00:00:00Z date_updated: 2021-01-12T06:58:40Z day: '01' doi: 10.1097/01.wnr.0000074344.81633.e4 extern: 1 intvolume: ' 14' issue: '7' month: '05' page: 947 - 950 publication: Neuroreport publication_status: published publisher: Lippincott, Williams & Wilkins publist_id: '4272' quality_controlled: 0 status: public title: Differential expression patterns of mGluR1α in monkey nigral dopamine neurons type: journal_article volume: 14 year: '2003' ... --- _id: '2627' abstract: - lang: eng text: Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain. author: - first_name: Ryosuke full_name: Kawakami, Ryosuke last_name: Kawakami - first_name: Yoshiaki full_name: Shinohara, Yoshiaki last_name: Shinohara - first_name: Yuichiro full_name: Kato, Yuichiro last_name: Kato - first_name: Hiroyuki full_name: Sugiyama, Hiroyuki last_name: Sugiyama - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Isao full_name: Ito, Isao last_name: Ito citation: ama: Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science. 2003;300(5621):990-994. doi:10.1126/science.1082609 apa: Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., & Ito, I. (2003). Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1082609 chicago: Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, and Isao Ito. “Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry.” Science. American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1082609. ieee: R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito, “Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry,” Science, vol. 300, no. 5621. American Association for the Advancement of Science, pp. 990–994, 2003. ista: Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science. 300(5621), 990–994. mla: Kawakami, Ryosuke, et al. “Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry.” Science, vol. 300, no. 5621, American Association for the Advancement of Science, 2003, pp. 990–94, doi:10.1126/science.1082609. short: R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Science 300 (2003) 990–994. date_created: 2018-12-11T11:58:45Z date_published: 2003-05-09T00:00:00Z date_updated: 2021-01-12T06:58:40Z day: '09' doi: 10.1126/science.1082609 extern: 1 intvolume: ' 300' issue: '5621' month: '05' page: 990 - 994 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '4271' quality_controlled: 0 status: public title: Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry type: journal_article volume: 300 year: '2003' ... --- _id: '2629' abstract: - lang: eng text: The release of neurotransmitters is modulated by presynaptic metabotropic glutamate receptors (mGluRs), which show a highly selective expression and subcellular location in glutamatergic terminals in the hippocampus. Using immunocytochemistry, we investigated whether one of the receptors, mGluR7, whose level of expression is governed by the postsynaptic target, was present in GABAergic terminals and whether such terminals targeted particular cells. A total of 165 interneuron dendritic profiles receiving 466 synapses (82% mGluR7a-positive) were analysed. The presynaptic active zones of most GAD-(77%) or GABA-positive (94%) synaptic boutons on interneurons innervated by mGluR7a-enriched glutamatergic terminals (mGluR7a-decorated) were immunopositive for mGluR7a. GABAergic terminals on pyramidal cells and most other interneurons in str. oriens were mGluR7a-immunonegative. The mGluR7a-decorated cells were mostly somatostatin- and mGluR1α-immunopositive neurons in str. oriens and the alveus. Their GABAergic input mainly originated from VIP-positive terminals, 90% of which expressed high levels of mGluR7a in the presynaptic active zone. Parvalbumin-positive synaptic terminals were rare on mGluR7a-decorated cells, but on these neurons 73% of them were mGluR7a-immunopositive. Some type II synapses innervating interneurons were immunopositive for mGluR7b, as were some type I synapses. Because not all target cells of VIP-positive neurons are known it has not been possible to determine whether mGluR7 is expressed in a target-cell-specific manner in the terminals of single GABAergic cells. The activation of mGluR7 may decrease GABA release to mGluR7-decorated cells at times of high pyramidal cell activity, which elevates extracellular glutamate levels. Alternatively, the presynaptic receptor may be activated by as yet unidentified endogenous ligands released by the GABAergic terminals or the postsynaptic dendrites. author: - first_name: Péter full_name: Somogyi, Péter last_name: Somogyi - first_name: Yannis full_name: Dalezios, Yannis last_name: Dalezios - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: John full_name: Roberts, John D last_name: Roberts - first_name: Masahiko full_name: Watanabe, Masahiko last_name: Watanabe - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. European Journal of Neuroscience. 2003;17(12):2503-2520. doi:10.1046/j.1460-9568.2003.02697.x apa: Somogyi, P., Dalezios, Y., Luján, R., Roberts, J., Watanabe, M., & Shigemoto, R. (2003). High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2003.02697.x chicago: Somogyi, Péter, Yannis Dalezios, Rafael Luján, John Roberts, Masahiko Watanabe, and Ryuichi Shigemoto. “High Level of MGluR7 in the Presynaptic Active Zones of Select Populations of GABAergic Terminals Innervating Interneurons in the Rat Hippocampus.” European Journal of Neuroscience. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1460-9568.2003.02697.x. ieee: P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, and R. Shigemoto, “High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus,” European Journal of Neuroscience, vol. 17, no. 12. Wiley-Blackwell, pp. 2503–2520, 2003. ista: Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. 2003. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. European Journal of Neuroscience. 17(12), 2503–2520. mla: Somogyi, Péter, et al. “High Level of MGluR7 in the Presynaptic Active Zones of Select Populations of GABAergic Terminals Innervating Interneurons in the Rat Hippocampus.” European Journal of Neuroscience, vol. 17, no. 12, Wiley-Blackwell, 2003, pp. 2503–20, doi:10.1046/j.1460-9568.2003.02697.x. short: P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, R. Shigemoto, European Journal of Neuroscience 17 (2003) 2503–2520. date_created: 2018-12-11T11:58:46Z date_published: 2003-06-01T00:00:00Z date_updated: 2021-01-12T06:58:41Z day: '01' doi: 10.1046/j.1460-9568.2003.02697.x extern: 1 intvolume: ' 17' issue: '12' month: '06' page: 2503 - 2520 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4269' quality_controlled: 0 status: public title: High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus type: journal_article volume: 17 year: '2003' ... --- _id: '2628' abstract: - lang: eng text: We aimed to estimate the number of AMPA receptors (AMPARs) bound by the quantal transmitter packet, their single-channel conductance and their density in the postsynaptic membrane at cerebellar Purkinje cell synapses. The synaptic and extrasynaptic AMPARs were examined in Purkinje cells in 2- to 4-day-old rats, when they receive synaptic inputs solely from climbing fibres (CFs). Evoked CF EPSCs and whole-cell AMPA currents displayed roughly linear current-voltage relationships, consistent with the presence of GluR2 subunits in synaptic and extrasynaptic AMPARs. The mean quantal size, estimated from the miniature EPSCs (MEPSCs), was ∼300 pS. Peak-scaled non-stationary fluctuation analysis of spontaneous EPSCs and MEPSCs gave a weighted-mean synaptic channel conductance of ∼5 pS (∼7 pS when corrected for filtering). By applying non-stationary fluctuation analysis to extrasynaptic currents activated by brief glutamate pulses (5 mM), we also obtained a small single-channel conductance estimate for extrasynaptic AMPARs (∼11 pS). This approach allowed us to obtain a maximum open probability (Po,max) value for the extrasynaptic receptors (Po,max = 0.72). Directly resolved extrasynaptic channel openings in the continued presence of glutamate exhibited clear multiple-conductance levels. The mean area of the postsynaptic density (PSD) of these synapses was 0.074 μm2, measured by reconstructing electron-microscopic (EM) serial sections. Postembedding immunogold labelling by anti-GluR2/3 antibody revealed that AMPARs are localised in PSDs. From these data and by simulating error factors, we estimate that at least 66 AMPARs are bound by a quantal transmitter packet at CF-Purkinje cell synapses, and the receptors are packed at a minimum density of ∼900 μm-2 in the postsynaptic membrane. author: - first_name: Akiko full_name: Momiyama, Akiko last_name: Momiyama - first_name: Rachel full_name: Silver, Rachel A last_name: Silver - first_name: Michael full_name: Häusser, Michael A last_name: Häusser - first_name: Takuya full_name: Notomi, Takuya last_name: Notomi - first_name: Yue full_name: Wu, Yue last_name: Wu - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Stuart full_name: Cull-Candy, Stuart G last_name: Cull Candy citation: ama: Momiyama A, Silver R, Häusser M, et al. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. Journal of Physiology. 2003;549(1):75-92. doi:10.1113/jphysiol.2002.033472 apa: Momiyama, A., Silver, R., Häusser, M., Notomi, T., Wu, Y., Shigemoto, R., & Cull Candy, S. (2003). The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2002.033472 chicago: Momiyama, Akiko, Rachel Silver, Michael Häusser, Takuya Notomi, Yue Wu, Ryuichi Shigemoto, and Stuart Cull Candy. “The Density of AMPA Receptors Activated by a Transmitter Quantum at the Climbing Fibre - Purkinje Cell Synapse in Immature Rats.” Journal of Physiology. Wiley-Blackwell, 2003. https://doi.org/10.1113/jphysiol.2002.033472. ieee: A. Momiyama et al., “The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats,” Journal of Physiology, vol. 549, no. 1. Wiley-Blackwell, pp. 75–92, 2003. ista: Momiyama A, Silver R, Häusser M, Notomi T, Wu Y, Shigemoto R, Cull Candy S. 2003. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats. Journal of Physiology. 549(1), 75–92. mla: Momiyama, Akiko, et al. “The Density of AMPA Receptors Activated by a Transmitter Quantum at the Climbing Fibre - Purkinje Cell Synapse in Immature Rats.” Journal of Physiology, vol. 549, no. 1, Wiley-Blackwell, 2003, pp. 75–92, doi:10.1113/jphysiol.2002.033472. short: A. Momiyama, R. Silver, M. Häusser, T. Notomi, Y. Wu, R. Shigemoto, S. Cull Candy, Journal of Physiology 549 (2003) 75–92. date_created: 2018-12-11T11:58:45Z date_published: 2003-05-15T00:00:00Z date_updated: 2021-01-12T06:58:40Z day: '15' doi: 10.1113/jphysiol.2002.033472 extern: 1 intvolume: ' 549' issue: '1' month: '05' page: 75 - 92 publication: Journal of Physiology publication_status: published publisher: Wiley-Blackwell publist_id: '4270' quality_controlled: 0 status: public title: The density of AMPA receptors activated by a transmitter quantum at the climbing fibre - Purkinje cell synapse in immature rats type: journal_article volume: 549 year: '2003' ... --- _id: '2631' abstract: - lang: eng text: Cyclic ADP-ribose (cADP-ribose) is a putative second messenger or modulator. However, the role of cADP-ribose in the downstream signals of the metabotropic glutamate receptors (mGluRs) is unclear. Here, we show that glutamate stimulates ADP-ribosyl cyclase activity in rat or mouse crude membranes of retina via group III mGluRs or in superior cervical ganglion via group I mGluRs. The retina of mGluR6-deficient mice showed no increase in the ADP-ribosyl cyclase level in response to glutamate. GTP enhanced the initial rate of basal and glutamate-stimulated cyclase activity. GTP-γ-S also stimulated basal activity. To determine whether the coupling mode of mGluRs to ADP-ribosyl cyclase is a feature common to individual cloned mGluRs, we expressed each mGluR subtype in NG108-15 neuroblastoma x glioma hybrid cells. The glutamate-induced stimulation of the cyclase occurs preferentially in NG108-15 cells over-expressing mGluRs1, 3, 5, and 6. Cells expressing mGluR2 or mGluRs4 and 7 exhibit inhibition or no coupling, respectively. Glutamate-induced activation or inhibition of the cyclase activity was eliminated after pre-treatment with cholera or pertussis toxin, respectively. Thus, the subtype-specific coupling of mGluRs to ADP-ribosyl cyclase via G proteins suggests that some glutamate-evoked neuronal functions are mediated by cADP-ribose. author: - first_name: Haruhiro full_name: Higashida, Haruhiro last_name: Higashida - first_name: Jia full_name: Zhang, Jia-Sheng last_name: Zhang - first_name: Sumiko full_name: Mochida, Sumiko last_name: Mochida - first_name: Xiao full_name: Chen, Xiao-Liang last_name: Chen - first_name: Yeonsook full_name: Shin, Yeonsook last_name: Shin - first_name: Mami full_name: Noda, Mami last_name: Noda - first_name: Kazi full_name: Hossain, Kazi Z last_name: Hossain - first_name: Naoto full_name: Hoshi, Naoto last_name: Hoshi - first_name: Minako full_name: Hashii, Minako last_name: Hashii - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi - first_name: Yutaka full_name: Fukuda, Yutaka last_name: Fukuda - first_name: Shigeru full_name: Yokoyama, Shigeru last_name: Yokoyama citation: ama: Higashida H, Zhang J, Mochida S, et al. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal of Neurochemistry. 2003;85(5):1148-1158. doi:10.1046/j.1471-4159.2003.01751.x apa: Higashida, H., Zhang, J., Mochida, S., Chen, X., Shin, Y., Noda, M., … Yokoyama, S. (2003). Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal of Neurochemistry. Wiley-Blackwell. https://doi.org/10.1046/j.1471-4159.2003.01751.x chicago: Higashida, Haruhiro, Jia Zhang, Sumiko Mochida, Xiao Chen, Yeonsook Shin, Mami Noda, Kazi Hossain, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” Journal of Neurochemistry. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1471-4159.2003.01751.x. ieee: H. Higashida et al., “Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells,” Journal of Neurochemistry, vol. 85, no. 5. Wiley-Blackwell, pp. 1148–1158, 2003. ista: Higashida H, Zhang J, Mochida S, Chen X, Shin Y, Noda M, Hossain K, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. 2003. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal of Neurochemistry. 85(5), 1148–1158. mla: Higashida, Haruhiro, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” Journal of Neurochemistry, vol. 85, no. 5, Wiley-Blackwell, 2003, pp. 1148–58, doi:10.1046/j.1471-4159.2003.01751.x. short: H. Higashida, J. Zhang, S. Mochida, X. Chen, Y. Shin, M. Noda, K. Hossain, N. Hoshi, M. Hashii, R. Shigemoto, S. Nakanishi, Y. Fukuda, S. Yokoyama, Journal of Neurochemistry 85 (2003) 1148–1158. date_created: 2018-12-11T11:58:46Z date_published: 2003-06-01T00:00:00Z date_updated: 2021-01-12T06:58:42Z day: '01' doi: 10.1046/j.1471-4159.2003.01751.x extern: 1 intvolume: ' 85' issue: '5' month: '06' page: 1148 - 1158 publication: Journal of Neurochemistry publication_status: published publisher: Wiley-Blackwell publist_id: '4268' quality_controlled: 0 status: public title: Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells type: journal_article volume: 85 year: '2003' ... --- _id: '2633' abstract: - lang: eng text: The modulation of calcium channels by metabotropic glutamate receptors (mGluRs) is a key event in the fine-tuning of neurotransmitter release. Here we report that, in cerebrocortical nerve terminals of adult rats, the inhibition of glutamate release is mediated by mGluR7. In this preparation, the major component of glutamate release is supported by P/Q-type Ca2+ channels (72.7%). However, mGluR7 selectively reduced the release component that is associated with N-type Ca2+ channels (29.9%). Inhibition of P/Q channels by mGluR7 is not masked by the higher efficiency of these channels in driving glutamate release when compared with N-type channels. Thus, activation of mGluR7 failed to reduce the release associated with P/Q channels when the extracellular calcium concentration, ([Ca2+]o), was reduced from 1.3 to 0.5 mM. Through Ca2+ imaging, we show that Ca2+ channels are distributed in a heterogeneous manner in individual nerve terminals. Indeed, in this preparation, nerve terminals were observed that contain N-type (31.1%; conotoxin GVIA-sensitive) or P/Q-type (64.3%; agatoxin IVA-sensitive) channels or that were insensitive to these two toxins (4.6%). Interestingly, the great majority of the responses to L-AP4 (95.4%) were observed in nerve terminals containing N-type channels. This specific co-localization of mGluR7 and N-type Ca2+-channels could explain the failure of the receptor to inhibit the P/Q channel-associated release component and also reveal the existence of specific targeting mechanisms to localize the two proteins in the same nerve terminal subset. author: - first_name: Carmelo full_name: Millán, Carmelo last_name: Millán - first_name: Enrique full_name: Castro, Enrique G last_name: Castro - first_name: Magdalena full_name: Torres, Magdalena last_name: Torres - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: José full_name: Sánchez-Prieto, José last_name: Sánchez Prieto citation: ama: Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. Journal of Biological Chemistry. 2003;278(26):23955-23962. doi:10.1074/jbc.M211471200 apa: Millán, C., Castro, E., Torres, M., Shigemoto, R., & Sánchez Prieto, J. (2003). Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M211471200 chicago: Millán, Carmelo, Enrique Castro, Magdalena Torres, Ryuichi Shigemoto, and José Sánchez Prieto. “Co-Expression of Metabotropic Glutamate Receptor 7 and N-Type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2003. https://doi.org/10.1074/jbc.M211471200. ieee: C. Millán, E. Castro, M. Torres, R. Shigemoto, and J. Sánchez Prieto, “Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats,” Journal of Biological Chemistry, vol. 278, no. 26. American Society for Biochemistry and Molecular Biology, pp. 23955–23962, 2003. ista: Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. 2003. Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats. Journal of Biological Chemistry. 278(26), 23955–23962. mla: Millán, Carmelo, et al. “Co-Expression of Metabotropic Glutamate Receptor 7 and N-Type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats.” Journal of Biological Chemistry, vol. 278, no. 26, American Society for Biochemistry and Molecular Biology, 2003, pp. 23955–62, doi:10.1074/jbc.M211471200. short: C. Millán, E. Castro, M. Torres, R. Shigemoto, J. Sánchez Prieto, Journal of Biological Chemistry 278 (2003) 23955–23962. date_created: 2018-12-11T11:58:47Z date_published: 2003-07-27T00:00:00Z date_updated: 2021-01-12T06:58:42Z day: '27' doi: 10.1074/jbc.M211471200 extern: 1 intvolume: ' 278' issue: '26' month: '07' page: 23955 - 23962 publication: Journal of Biological Chemistry publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '4265' quality_controlled: 0 status: public title: Co-expression of metabotropic glutamate receptor 7 and N-type Ca2+ channels in single cerebrocortical nerve terminals of adult rats type: journal_article volume: 278 year: '2003' ... --- _id: '2632' abstract: - lang: eng text: In many brain regions, hyperpolarization-activated cationic currents (Ih) are involved in the generation of rhythmic activities, but the role of Ih in olfactory oscillations remains unclear. Knowledge of the cellular and subcellular distributions of hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) subunits is necessary for understanding the role of Ih in olfactory network activities. Using light microscopic immunocytochemistry, we demonstrate strong HCN1 labelling of the glomerular layer and moderate staining of granule cell, internal and external plexiform layers of the rat main olfactory bulb. In the glomerular layer, among many unlabelled neurons, two distinct subpopulations of juxtaglomerular cells are labelled. Approximately 10% of the juxtaglomerular cells strongly express HCN1. These small diameter cells are immunoreactive for GABA and comprise a subpopulation of periglomerular cells. An additional subset of juxtaglomerular cells (≈ 1%) expresses low levels of HCN1. They are large in diameter, GABA immunonegative but immunopositive for vesicular glutamate transporter 2, characterizing them as external tufted cells. Quantitative immunogold localization revealed that the somatic plasma membranes of periglomerular cells contain approximately four times more HCN1 labelling than those of external tufted cells. Unlike in cortical pyramidal cells, immunogold density for HCN1 does not significantly differ in somatic and dendritic plasma membranes of external tufted cells, indicating that post-synaptic potentials arriving at proximal and distal dendrites are modulated by the same density of I h. Our results demonstrate a cell type-dependent expression of HCN1 in the olfactory bulb and predict a differential contribution of distinct juxtaglomerular cell types to network oscillations. author: - first_name: Noémi full_name: Holderith, Noémi B last_name: Holderith - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Zoltán full_name: Nusser, Zoltán last_name: Nusser citation: ama: Holderith N, Shigemoto R, Nusser Z. Cell type-dependent expression of HCN1 in the main olfactory bulb. European Journal of Neuroscience. 2003;18(2):344-354. doi:10.1046/j.1460-9568.2003.02756.x apa: Holderith, N., Shigemoto, R., & Nusser, Z. (2003). Cell type-dependent expression of HCN1 in the main olfactory bulb. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2003.02756.x chicago: Holderith, Noémi, Ryuichi Shigemoto, and Zoltán Nusser. “Cell Type-Dependent Expression of HCN1 in the Main Olfactory Bulb.” European Journal of Neuroscience. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1460-9568.2003.02756.x. ieee: N. Holderith, R. Shigemoto, and Z. Nusser, “Cell type-dependent expression of HCN1 in the main olfactory bulb,” European Journal of Neuroscience, vol. 18, no. 2. Wiley-Blackwell, pp. 344–354, 2003. ista: Holderith N, Shigemoto R, Nusser Z. 2003. Cell type-dependent expression of HCN1 in the main olfactory bulb. European Journal of Neuroscience. 18(2), 344–354. mla: Holderith, Noémi, et al. “Cell Type-Dependent Expression of HCN1 in the Main Olfactory Bulb.” European Journal of Neuroscience, vol. 18, no. 2, Wiley-Blackwell, 2003, pp. 344–54, doi:10.1046/j.1460-9568.2003.02756.x. short: N. Holderith, R. Shigemoto, Z. Nusser, European Journal of Neuroscience 18 (2003) 344–354. date_created: 2018-12-11T11:58:47Z date_published: 2003-07-01T00:00:00Z date_updated: 2021-01-12T06:58:42Z day: '01' doi: 10.1046/j.1460-9568.2003.02756.x extern: 1 intvolume: ' 18' issue: '2' month: '07' page: 344 - 354 publication: European Journal of Neuroscience publication_status: published publisher: Wiley-Blackwell publist_id: '4266' quality_controlled: 0 status: public title: Cell type-dependent expression of HCN1 in the main olfactory bulb type: journal_article volume: 18 year: '2003' ... --- _id: '2635' abstract: - lang: eng text: Metabotropic GABAB receptors mediate slow inhibitory effects presynaptically and postsynaptically. Using preembedding immunohistochemical methods combined with quantitative analysis of GABAB receptor subunit immunoreactivity, this study provides a detailed description of the cellular and subcellular localization of GABAB1a/b and GABA B2 in the rat hippocampus. At the light microscopic level, an overlapping distribution of GABAB1a/b and GABAB2 was revealed in the dendritic layers of the hippocampus. In addition, expression of the GABAB1a/b subunit was found in somata of CA1 pyramidal cells and of a subset of GABAergic interneurons. At the electron microscopic level, immunoreactivity for both subunits was observed on presynaptic and, more abundantly, on postsynaptic elements. Presynaptically, subunits were mainly detected in the extrasynaptic membrane and occasionally over the presynaptic membrane specialization of putative glutamatergic and, to a lesser extent, GABAergic axon terminals. Postsynaptically, the majority of GABAB receptor subunits were localized to the extrasynaptic plasma membrane of spines and dendritic shafts of principal cells and shafts of interneuron dendrites. Quantitative analysis revealed enrichment of GABAB1a/b around putative glutamatergic synapses on spines and an even distribution on dendritic shafts of pyramidal cells contacted by GABAergic boutons. The association of GABAB receptors with glutamatergic synapses at both presynaptic and postsynaptic sides indicates their intimate involvement in the modulation of glutamatergic neurotransmission. The dominant extrasynaptic localization of GABAB receptor subunits suggests that their activation is dependent on spillover of GABA requiring simultaneous activity of populations of GABAergic cells as it occurs during population oscillations or epileptic seizures. author: - first_name: Ákos full_name: Kulik, Ákos last_name: Kulik - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Carola full_name: Haas, Carola A last_name: Haas - first_name: Guillermina full_name: López-Bendito, Guillermina last_name: López Bendito - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher citation: ama: Kulik Á, Vida I, Luján R, et al. Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience. 2003;23(35):11026-11035. apa: Kulik, Á., Vida, I., Luján, R., Haas, C., López Bendito, G., Shigemoto, R., & Frotscher, M. (2003). Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience. Society for Neuroscience. chicago: Kulik, Ákos, Imre Vida, Rafael Luján, Carola Haas, Guillermina López Bendito, Ryuichi Shigemoto, and Michael Frotscher. “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 2003. ieee: Á. Kulik et al., “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus,” Journal of Neuroscience, vol. 23, no. 35. Society for Neuroscience, pp. 11026–11035, 2003. ista: Kulik Á, Vida I, Luján R, Haas C, López Bendito G, Shigemoto R, Frotscher M. 2003. Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus. Journal of Neuroscience. 23(35), 11026–11035. mla: Kulik, Ákos, et al. “Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.” Journal of Neuroscience, vol. 23, no. 35, Society for Neuroscience, 2003, pp. 11026–35. short: Á. Kulik, I. Vida, R. Luján, C. Haas, G. López Bendito, R. Shigemoto, M. Frotscher, Journal of Neuroscience 23 (2003) 11026–11035. date_created: 2018-12-11T11:58:47Z date_published: 2003-12-03T00:00:00Z date_updated: 2021-01-12T06:58:43Z day: '03' extern: 1 intvolume: ' 23' issue: '35' month: '12' page: 11026 - 11035 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '4263' quality_controlled: 0 status: public title: Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus type: journal_article volume: 23 year: '2003' ... --- _id: '2634' abstract: - lang: eng text: To better understand the role of neurotransmitter receptors in neuronal differentiation and maturation a detailed knowledge of their identity, location and function in the plasma membrane of specific neuronal populations during development is required. Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain slice cultures we show that virtually all neurons (∼98%) migrating through the lower intermediate zone (LIZ) on their way from the medial ganglionic eminence to the cerebral cortex, express GABA BR1. Blockade of GABABRs with a specific antagonist, CGP52432, resulted in a concentration-dependent accumulation of these tangentially migrating neurons in the ventricular/subventricular zones (VZ/SVZ) of the cortex and fewer cells were observed in the cortical plate/marginal zone (CP/MZ) and LIZ. Moreover, they had significantly shorter leading processes compared with similar migrating cells in control slices. Electrophysiological recording in LIZ and CP cells revealed no direct effect of either CGP52432 or the GABABR agonist, baclofen, on resting membrane properties suggesting that the effect of CGP52432 on migration might be mediated through a metabotropic action or the regulation of release of factors controlling migration. These results suggest that GABABRs have an important modulatory role in the migration of cortical interneurons. author: - first_name: Guillermina full_name: López-Bendito, Guillermina last_name: López Bendito - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Paul full_name: Ganter, Paul last_name: Ganter - first_name: Ole full_name: Paulsen, Ole last_name: Paulsen - first_name: Zoltán full_name: Molnár, Zoltán last_name: Molnár citation: ama: López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. Blockade of GABAB receptors alters the tangential migration of cortical neurons. Cerebral Cortex. 2003;13(9):932-942. doi:10.1093/cercor/13.9.932 apa: López Bendito, G., Luján, R., Shigemoto, R., Ganter, P., Paulsen, O., & Molnár, Z. (2003). Blockade of GABAB receptors alters the tangential migration of cortical neurons. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/13.9.932 chicago: López Bendito, Guillermina, Rafael Luján, Ryuichi Shigemoto, Paul Ganter, Ole Paulsen, and Zoltán Molnár. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” Cerebral Cortex. Oxford University Press, 2003. https://doi.org/10.1093/cercor/13.9.932. ieee: G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, and Z. Molnár, “Blockade of GABAB receptors alters the tangential migration of cortical neurons,” Cerebral Cortex, vol. 13, no. 9. Oxford University Press, pp. 932–942, 2003. ista: López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. 2003. Blockade of GABAB receptors alters the tangential migration of cortical neurons. Cerebral Cortex. 13(9), 932–942. mla: López Bendito, Guillermina, et al. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” Cerebral Cortex, vol. 13, no. 9, Oxford University Press, 2003, pp. 932–42, doi:10.1093/cercor/13.9.932. short: G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, Z. Molnár, Cerebral Cortex 13 (2003) 932–942. date_created: 2018-12-11T11:58:47Z date_published: 2003-09-01T00:00:00Z date_updated: 2021-01-12T06:58:43Z day: '01' doi: 10.1093/cercor/13.9.932 extern: 1 intvolume: ' 13' issue: '9' month: '09' page: 932 - 942 publication: Cerebral Cortex publication_status: published publisher: Oxford University Press publist_id: '4264' quality_controlled: 0 status: public title: Blockade of GABAB receptors alters the tangential migration of cortical neurons type: journal_article volume: 13 year: '2003' ... --- _id: '2630' abstract: - lang: eng text: Taste-metabotropic glutamate receptor 4 (taste-mGluR4) and the heteromers of T1R1 and T1R3 are candidate receptors involved in the sense of umami (monosodium glutamate) taste. Although the expression of group III mGluRs (taste-mGluR4) has been demonstrated in taste tissues, no mention has been made of the expression of group I mGluRs (mGluR1 and mGluR5) in taste tissues. We examined the expression of mGluR1 and mGluR5 in rat gustatory tissues by using reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoelectron microscopy. RT-PCR assay showed that mGluR1α and mGluR1β mRNAs were expressed in circumvallate papillae, but mGluR5 mRNA was not expressed. The positive signals of mGluR1 mRNA were detected only in circumvallate taste buds by in situ hybridization analysis. In cryosections of fungiform, foliate and circumvallate papillae, the antibody against mGluRla gave intense labeling on the taste hairs in all taste pores examined. In the developing taste buds, the positive signals of mGluR1α in taste hairs gradually increased with the increase in number of taste bud cells. These results show that, in addition to taste-mGluR4 and the heteromer of T1R1 and T1R3, mGluR1α may function as a receptor for glutamate (umami) taste sensation. author: - first_name: Takashi full_name: Toyono, Takashi last_name: Toyono - first_name: Yuji full_name: Seta, Yuji last_name: Seta - first_name: Shinji full_name: Kataoka, Shinji last_name: Kataoka - first_name: Shintaro full_name: Kawano, Shintaro last_name: Kawano - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Kuniaki full_name: Toyoshima, Kuniaki last_name: Toyoshima citation: ama: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and Tissue Research. 2003;313(1):29-35. doi:10.1007/s00441-003-0740-2 apa: Toyono, T., Seta, Y., Kataoka, S., Kawano, S., Shigemoto, R., & Toyoshima, K. (2003). Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and Tissue Research. Springer. https://doi.org/10.1007/s00441-003-0740-2 chicago: Toyono, Takashi, Yuji Seta, Shinji Kataoka, Shintaro Kawano, Ryuichi Shigemoto, and Kuniaki Toyoshima. “Expression of Metabotropic Glutamate Receptor Group I in Rat Gustatory Papillae.” Cell and Tissue Research. Springer, 2003. https://doi.org/10.1007/s00441-003-0740-2. ieee: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, and K. Toyoshima, “Expression of metabotropic glutamate receptor group I in rat gustatory papillae,” Cell and Tissue Research, vol. 313, no. 1. Springer, pp. 29–35, 2003. ista: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. 2003. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and Tissue Research. 313(1), 29–35. mla: Toyono, Takashi, et al. “Expression of Metabotropic Glutamate Receptor Group I in Rat Gustatory Papillae.” Cell and Tissue Research, vol. 313, no. 1, Springer, 2003, pp. 29–35, doi:10.1007/s00441-003-0740-2. short: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, K. Toyoshima, Cell and Tissue Research 313 (2003) 29–35. date_created: 2018-12-11T11:58:46Z date_published: 2003-07-01T00:00:00Z date_updated: 2021-01-12T06:58:41Z day: '01' doi: 10.1007/s00441-003-0740-2 extern: 1 intvolume: ' 313' issue: '1' month: '07' page: 29 - 35 publication: Cell and Tissue Research publication_status: published publisher: Springer publist_id: '4267' quality_controlled: 0 status: public title: Expression of metabotropic glutamate receptor group I in rat gustatory papillae type: journal_article volume: 313 year: '2003' ... --- _id: '2637' abstract: - lang: eng text: While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive. Our study demonstrates a clear involvement of both glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent quantification has revealed a statistically significant increased density of glutamatergic and GABAergic presynaptic boutons in both the plaque free and plaque adjacent cortical neuropile areas of transgenic mice as compared to non-transgenic controls. Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile. These findings support our hypothesis that the amyloid pathology progresses in a time and neurotransmitter specific manner, first in the cholinergic system which appears to be most vulnerable, followed by the glutamatergic presynaptic boutons and finally the somewhat more resilient GABAergic terminals. author: - first_name: Karen full_name: Bell, Karen F last_name: Bell - first_name: G J full_name: De Kort, G J last_name: De Kort - first_name: S full_name: Steggerda, S last_name: Steggerda - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Alfredo full_name: Ribeiro-da-Silva, Alfredo last_name: Ribeiro Da Silva - first_name: Augusto full_name: Cuello, Augusto C last_name: Cuello citation: ama: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. 2003;353(2):143-147. doi:10.1016/j.neulet.2003.09.027 apa: Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A., & Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. Elsevier. https://doi.org/10.1016/j.neulet.2003.09.027 chicago: Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” Neuroscience Letters. Elsevier, 2003. https://doi.org/10.1016/j.neulet.2003.09.027. ieee: K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology,” Neuroscience Letters, vol. 353, no. 2. Elsevier, pp. 143–147, 2003. ista: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. 2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2), 143–147. mla: Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” Neuroscience Letters, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:10.1016/j.neulet.2003.09.027. short: K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A. Cuello, Neuroscience Letters 353 (2003) 143–147. date_created: 2018-12-11T11:58:48Z date_published: 2003-12-19T00:00:00Z date_updated: 2021-01-12T06:58:44Z day: '19' doi: 10.1016/j.neulet.2003.09.027 extern: 1 intvolume: ' 353' issue: '2' month: '12' page: 143 - 147 publication: Neuroscience Letters publication_status: published publisher: Elsevier publist_id: '4262' quality_controlled: 0 status: public title: Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology type: journal_article volume: 353 year: '2003' ... --- _id: '2784' abstract: - lang: eng text: We report the results of an experimental study of magnetohydrodynamic damping of sidewall convection in a rectangular enclosure filled with gallium. In particular we investigate the suppression of convection when a steady magnetic field is applied separately in each of the three principal directions of the flow. The strongest damping of the steady flow is found for a vertical magnetic field, which is in agreement with theory. However, we observe that the application of a field transverse to the flow provides greater damping than a longitudinal one, which seems to contradict available theory. We provide a possible resolution of this apparent dichotomy in terms of the length scale of the experiment. author: - first_name: Björn full_name: Björn Hof id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 - first_name: Anne full_name: Juel, Anne last_name: Juel - first_name: Tom full_name: Mullin, Tom P last_name: Mullin citation: ama: Hof B, Juel A, Mullin T. Magnetohydrodynamic damping of convective flows in molten gallium. Journal of Fluid Mechanics. 2003;482:163-179. doi:10.1017/S0022112003004014 apa: Hof, B., Juel, A., & Mullin, T. (2003). Magnetohydrodynamic damping of convective flows in molten gallium. Journal of Fluid Mechanics. Cambridge University Press. https://doi.org/10.1017/S0022112003004014 chicago: Hof, Björn, Anne Juel, and Tom Mullin. “Magnetohydrodynamic Damping of Convective Flows in Molten Gallium.” Journal of Fluid Mechanics. Cambridge University Press, 2003. https://doi.org/10.1017/S0022112003004014. ieee: B. Hof, A. Juel, and T. Mullin, “Magnetohydrodynamic damping of convective flows in molten gallium,” Journal of Fluid Mechanics, vol. 482. Cambridge University Press, pp. 163–179, 2003. ista: Hof B, Juel A, Mullin T. 2003. Magnetohydrodynamic damping of convective flows in molten gallium. Journal of Fluid Mechanics. 482, 163–179. mla: Hof, Björn, et al. “Magnetohydrodynamic Damping of Convective Flows in Molten Gallium.” Journal of Fluid Mechanics, vol. 482, Cambridge University Press, 2003, pp. 163–79, doi:10.1017/S0022112003004014. short: B. Hof, A. Juel, T. Mullin, Journal of Fluid Mechanics 482 (2003) 163–179. date_created: 2018-12-11T11:59:35Z date_published: 2003-05-13T00:00:00Z date_updated: 2021-01-12T06:59:42Z day: '13' doi: 10.1017/S0022112003004014 extern: 1 intvolume: ' 482' month: '05' page: 163 - 179 publication: Journal of Fluid Mechanics publication_status: published publisher: Cambridge University Press publist_id: '4105' quality_controlled: 0 status: public title: Magnetohydrodynamic damping of convective flows in molten gallium type: journal_article volume: 482 year: '2003' ... --- _id: '2785' abstract: - lang: eng text: Experimental evidence for the scaling of the finite amplitude of perturbation theory required to promote transition in Poiseuille flow was found. The exponent is -1 and was uncovered using considerable care in the design and execution of the experiment. Interestingly, this exponent was also found in experiments on transition in boundary layers. author: - first_name: Björn full_name: Björn Hof id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 - first_name: Anne full_name: Juel, Anne last_name: Juel - first_name: Tom full_name: Mullin, Tom P last_name: Mullin citation: ama: Hof B, Juel A, Mullin T. Scaling of the turbulence transition threshold in a pipe. Physical Review Letters. 2003;91(24):244502/1-244502/4. doi:10.1103/PhysRevLett.91.244502 apa: Hof, B., Juel, A., & Mullin, T. (2003). Scaling of the turbulence transition threshold in a pipe. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.91.244502 chicago: Hof, Björn, Anne Juel, and Tom Mullin. “Scaling of the Turbulence Transition Threshold in a Pipe.” Physical Review Letters. American Physical Society, 2003. https://doi.org/10.1103/PhysRevLett.91.244502. ieee: B. Hof, A. Juel, and T. Mullin, “Scaling of the turbulence transition threshold in a pipe,” Physical Review Letters, vol. 91, no. 24. American Physical Society, p. 244502/1-244502/4, 2003. ista: Hof B, Juel A, Mullin T. 2003. Scaling of the turbulence transition threshold in a pipe. Physical Review Letters. 91(24), 244502/1-244502/4. mla: Hof, Björn, et al. “Scaling of the Turbulence Transition Threshold in a Pipe.” Physical Review Letters, vol. 91, no. 24, American Physical Society, 2003, p. 244502/1-244502/4, doi:10.1103/PhysRevLett.91.244502. short: B. Hof, A. Juel, T. Mullin, Physical Review Letters 91 (2003) 244502/1-244502/4. date_created: 2018-12-11T11:59:35Z date_published: 2003-12-12T00:00:00Z date_updated: 2021-01-12T06:59:42Z day: '12' doi: 10.1103/PhysRevLett.91.244502 extern: 1 intvolume: ' 91' issue: '24' month: '12' page: 244502/1 - 244502/4 publication: Physical Review Letters publication_status: published publisher: American Physical Society publist_id: '4104' quality_controlled: 0 status: public title: Scaling of the turbulence transition threshold in a pipe type: journal_article volume: 91 year: '2003' ... --- _id: '2990' abstract: - lang: eng text: Plant growth is marked by its adaptability to continuous changes in environment. A regulated, differential distribution of auxin underlies many adaptation processes including organogenesis, meristem patterning and tropisms. In executing its multiple roles, auxin displays some characteristics of both a hormone and a morphogen. Studies on auxin transport, as well as tracing the intracellular movement of its molecular components, have suggested a possible scenario to explain how growth plasticity is conferred at the cellular and molecular level. The plant perceives stimuli and changes the subcellular position of auxin-transport components accordingly. These changes modulate auxin fluxes, and the newly established auxin distribution triggers the corresponding developmental response. author: - first_name: Jirí full_name: Friml, Jirí id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Friml J. Auxin transport - Shaping the plant. Current Opinion in Plant Biology. 2003;6(1):7-12. doi:10.1016/S1369526602000031 apa: Friml, J. (2003). Auxin transport - Shaping the plant. Current Opinion in Plant Biology. Elsevier. https://doi.org/10.1016/S1369526602000031 chicago: Friml, Jiří. “Auxin Transport - Shaping the Plant.” Current Opinion in Plant Biology. Elsevier, 2003. https://doi.org/10.1016/S1369526602000031. ieee: J. Friml, “Auxin transport - Shaping the plant,” Current Opinion in Plant Biology, vol. 6, no. 1. Elsevier, pp. 7–12, 2003. ista: Friml J. 2003. Auxin transport - Shaping the plant. Current Opinion in Plant Biology. 6(1), 7–12. mla: Friml, Jiří. “Auxin Transport - Shaping the Plant.” Current Opinion in Plant Biology, vol. 6, no. 1, Elsevier, 2003, pp. 7–12, doi:10.1016/S1369526602000031. short: J. Friml, Current Opinion in Plant Biology 6 (2003) 7–12. date_created: 2018-12-11T12:00:43Z date_published: 2003-02-01T00:00:00Z date_updated: 2021-01-12T07:40:17Z day: '01' doi: 10.1016/S1369526602000031 extern: '1' intvolume: ' 6' issue: '1' language: - iso: eng month: '02' oa_version: None page: 7 - 12 publication: Current Opinion in Plant Biology publication_status: published publisher: Elsevier publist_id: '3711' quality_controlled: '1' status: public title: Auxin transport - Shaping the plant type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 6 year: '2003' ... --- _id: '2992' abstract: - lang: eng text: Plants have many polarized cell types, but relatively little is known about the mechanisms that establish polarity. The orc mutant was identified originally by defects in root patterning, and positional cloning revealed that the affected gene encodes STEROL METHYLTRANSFERASE1, which is required for the appropriate synthesis and composition of major membrane sterols. smt1orc mutants displayed several conspicuous cell polarity defects. Columella root cap cells revealed perturbed polar positioning of different organelles, and in the smt1orc root epidermis, polar initiation of root hairs was more randomized. Polar auxin transport and expression of the auxin reporter DR5-β-glucuronidase were aberrant in smt1orc. Patterning defects in smt1orc resembled those observed in mutants of the PIN gene family of putative auxin efflux transporters. Consistently, the membrane localization of the PIN1 and PIN3 proteins was disturbed in smt1orc, whereas polar positioning of the influx carrier AUX1 appeared normal. Our results suggest that balanced sterol composition is a major requirement for cell polarity and auxin efflux in Arabidopsis. author: - first_name: Viola full_name: Willemsen, Viola last_name: Willemsen - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Markus full_name: Grebe, Markus last_name: Grebe - first_name: Albert full_name: Van Den Toorn, Albert last_name: Van Den Toorn - first_name: Klaus full_name: Palme, Klaus last_name: Palme - first_name: Ben full_name: Scheres, Ben last_name: Scheres citation: ama: Willemsen V, Friml J, Grebe M, Van Den Toorn A, Palme K, Scheres B. Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. Plant Cell. 2003;15(3):612-625. doi:10.1105/tpc.008433 apa: Willemsen, V., Friml, J., Grebe, M., Van Den Toorn, A., Palme, K., & Scheres, B. (2003). Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. Plant Cell. American Society of Plant Biologists. https://doi.org/10.1105/tpc.008433 chicago: Willemsen, Viola, Jiří Friml, Markus Grebe, Albert Van Den Toorn, Klaus Palme, and Ben Scheres. “Cell Polarity and PIN Protein Positioning in Arabidopsis Require STEROL METHYLTRANSFERASE1 Function.” Plant Cell. American Society of Plant Biologists, 2003. https://doi.org/10.1105/tpc.008433. ieee: V. Willemsen, J. Friml, M. Grebe, A. Van Den Toorn, K. Palme, and B. Scheres, “Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function,” Plant Cell, vol. 15, no. 3. American Society of Plant Biologists, pp. 612–625, 2003. ista: Willemsen V, Friml J, Grebe M, Van Den Toorn A, Palme K, Scheres B. 2003. Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. Plant Cell. 15(3), 612–625. mla: Willemsen, Viola, et al. “Cell Polarity and PIN Protein Positioning in Arabidopsis Require STEROL METHYLTRANSFERASE1 Function.” Plant Cell, vol. 15, no. 3, American Society of Plant Biologists, 2003, pp. 612–25, doi:10.1105/tpc.008433. short: V. Willemsen, J. Friml, M. Grebe, A. Van Den Toorn, K. Palme, B. Scheres, Plant Cell 15 (2003) 612–625. date_created: 2018-12-11T12:00:44Z date_published: 2003-03-01T00:00:00Z date_updated: 2021-01-12T07:40:18Z day: '01' doi: 10.1105/tpc.008433 extern: 1 intvolume: ' 15' issue: '3' month: '03' page: 612 - 625 publication: Plant Cell publication_status: published publisher: American Society of Plant Biologists publist_id: '3710' quality_controlled: 0 status: public title: Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function type: journal_article volume: 15 year: '2003' ... --- _id: '2996' abstract: - lang: eng text: | Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coordinated cell division and differentiation. Here, we show that organ formation in Arabidopsis involves dynamic gradients of the signaling molecule auxin with maxima at the primordia tips. These gradients are mediated by cellular efflux requiring asymmetrically localized PIN proteins, which represent a functionally redundant network for auxin distribution in both aerial and underground organs. PIN1 polar localization undergoes a dynamic rearrangement, which correlates with establishment of auxin gradients and primordium development. Our results suggest that PIN-dependent, local auxin gradients represent a common module for formation of all plant organs, regardless of their mature morphology or developmental origin. author: - first_name: Eva full_name: Eva Benková id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Marta full_name: Michniewicz, Marta last_name: Michniewicz - first_name: Michael full_name: Sauer, Michael last_name: Sauer - first_name: Thomas full_name: Teichmann, Thomas last_name: Teichmann - first_name: Daniela full_name: Seifertová, Daniela last_name: Seifertová - first_name: Gerd full_name: Jürgens, Gerd last_name: Jürgens - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Benková E, Michniewicz M, Sauer M, et al. Local, efflux-dependent auxin gradients as a common module for plant organ formation. Cell. 2003;115(5):591-602. doi:10.1016/S0092-8674(03)00924-3 apa: Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003). Local, efflux-dependent auxin gradients as a common module for plant organ formation. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(03)00924-3 chicago: Benková, Eva, Marta Michniewicz, Michael Sauer, Thomas Teichmann, Daniela Seifertová, Gerd Jürgens, and Jiří Friml. “Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation.” Cell. Cell Press, 2003. https://doi.org/10.1016/S0092-8674(03)00924-3. ieee: E. Benková et al., “Local, efflux-dependent auxin gradients as a common module for plant organ formation,” Cell, vol. 115, no. 5. Cell Press, pp. 591–602, 2003. ista: Benková E, Michniewicz M, Sauer M, Teichmann T, Seifertová D, Jürgens G, Friml J. 2003. Local, efflux-dependent auxin gradients as a common module for plant organ formation. Cell. 115(5), 591–602. mla: Benková, Eva, et al. “Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation.” Cell, vol. 115, no. 5, Cell Press, 2003, pp. 591–602, doi:10.1016/S0092-8674(03)00924-3. short: E. Benková, M. Michniewicz, M. Sauer, T. Teichmann, D. Seifertová, G. Jürgens, J. Friml, Cell 115 (2003) 591–602. date_created: 2018-12-11T12:00:46Z date_published: 2003-11-26T00:00:00Z date_updated: 2021-01-12T07:40:19Z day: '26' doi: 10.1016/S0092-8674(03)00924-3 extern: 1 intvolume: ' 115' issue: '5' month: '11' page: 591 - 602 publication: Cell publication_status: published publisher: Cell Press publist_id: '3706' quality_controlled: 0 status: public title: Local, efflux-dependent auxin gradients as a common module for plant organ formation type: journal_article volume: 115 year: '2003' ... --- _id: '2995' abstract: - lang: eng text: | Axis formation occurs in plants, as in animals, during early embryogenesis. However, the underlying mechanism is not known. Here we show that the first manifestation of the apical-basal axis in plants, the asymmetric division of the zygote, produces a basal cell that transports and an apical cell that responds to the signalling molecule auxin. This apical-basal auxin activity gradient triggers the specification of apical embryo structures and is actively maintained by a novel component of auxin efflux, PIN7, which is located apically in the basal cell. Later, the developmentally regulated reversal of PIN7 and onset of PIN1 polar localization reorganize the auxin gradient for specification of the basal root pole. An analysis of pin quadruple mutants identifies PIN-dependent transport as an essential part of the mechanism for embryo axis formation. Our results indicate how the establishment of cell polarity, polar auxin efflux and local auxin response result in apical-basal axis formation of the embryo, and thus determine the axiality of the adult plant. author: - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Anne full_name: Vieten, Anne last_name: Vieten - first_name: Michael full_name: Sauer, Michael last_name: Sauer - first_name: Dolf full_name: Weijers, Dolf last_name: Weijers - first_name: Heinz full_name: Schwarz, Heinz last_name: Schwarz - first_name: Thorsten full_name: Hamann, Thorsten last_name: Hamann - first_name: Remko full_name: Offringa, Remko last_name: Offringa - first_name: Gerd full_name: Jürgens, Gerd last_name: Jürgens citation: ama: Friml J, Vieten A, Sauer M, et al. Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis. Nature. 2003;426(6963):147-153. doi:10.1038/nature02085 apa: Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., … Jürgens, G. (2003). Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis. Nature. Nature Publishing Group. https://doi.org/10.1038/nature02085 chicago: Friml, Jiří, Anne Vieten, Michael Sauer, Dolf Weijers, Heinz Schwarz, Thorsten Hamann, Remko Offringa, and Gerd Jürgens. “Efflux Dependent Auxin Gradients Establish the Apical Basal Axis of Arabidopsis.” Nature. Nature Publishing Group, 2003. https://doi.org/10.1038/nature02085. ieee: J. Friml et al., “Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis,” Nature, vol. 426, no. 6963. Nature Publishing Group, pp. 147–153, 2003. ista: Friml J, Vieten A, Sauer M, Weijers D, Schwarz H, Hamann T, Offringa R, Jürgens G. 2003. Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis. Nature. 426(6963), 147–153. mla: Friml, Jiří, et al. “Efflux Dependent Auxin Gradients Establish the Apical Basal Axis of Arabidopsis.” Nature, vol. 426, no. 6963, Nature Publishing Group, 2003, pp. 147–53, doi:10.1038/nature02085. short: J. Friml, A. Vieten, M. Sauer, D. Weijers, H. Schwarz, T. Hamann, R. Offringa, G. Jürgens, Nature 426 (2003) 147–153. date_created: 2018-12-11T12:00:45Z date_published: 2003-11-13T00:00:00Z date_updated: 2021-01-12T07:40:19Z day: '13' doi: 10.1038/nature02085 extern: 1 intvolume: ' 426' issue: '6963' month: '11' page: 147 - 153 publication: Nature publication_status: published publisher: Nature Publishing Group publist_id: '3708' quality_controlled: 0 status: public title: Efflux dependent auxin gradients establish the apical basal axis of Arabidopsis type: journal_article volume: 426 year: '2003' ... --- _id: '2994' abstract: - lang: eng text: The regular arrangement of leaves around a plant's stem, called phyllotaxis, has for centuries attracted the attention of philosophers, mathematicians and natural scientists; however, to date, studies of phyllotaxis have been largely theoretical. Leaves and flowers are formed from the shoot apical meristem, triggered by the plant hormone auxin. Auxin is transported through plant tissues by specific cellular influx and efflux carrier proteins. Here we show that proteins involved in auxin transport regulate phyllotaxis. Our data indicate that auxin is transported upwards into the meristem through the epidermis and the outermost meristem cell layer. Existing leaf primordia act as sinks, redistributing auxin and creating its heterogeneous distribution in the meristem. Auxin accumulation occurs only at certain minimal distances from existing primordia, defining the position of future primordia. This model for phyllotaxis accounts for its reiterative nature, as well as its regularity and stability. author: - first_name: Didier full_name: Reinhardt, Didier last_name: Reinhardt - first_name: Eva full_name: Pesce, Eva-Rachele last_name: Pesce - first_name: Pia full_name: Stieger, Pia last_name: Stieger - first_name: Therese full_name: Mandel, Therese last_name: Mandel - first_name: Kurt full_name: Baltensperger, Kurt last_name: Baltensperger - first_name: Malcolm full_name: Bennett, Malcolm last_name: Bennett - first_name: Jan full_name: Traas, Jan last_name: Traas - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Cris full_name: Kuhlemeier, Cris last_name: Kuhlemeier citation: ama: Reinhardt D, Pesce E, Stieger P, et al. Regulation of phyllotaxis by polar auxin transport. Nature. 2003;426(6964):255-260. doi:10.1038/nature02081 apa: Reinhardt, D., Pesce, E., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., … Kuhlemeier, C. (2003). Regulation of phyllotaxis by polar auxin transport. Nature. Nature Publishing Group. https://doi.org/10.1038/nature02081 chicago: Reinhardt, Didier, Eva Pesce, Pia Stieger, Therese Mandel, Kurt Baltensperger, Malcolm Bennett, Jan Traas, Jiří Friml, and Cris Kuhlemeier. “Regulation of Phyllotaxis by Polar Auxin Transport.” Nature. Nature Publishing Group, 2003. https://doi.org/10.1038/nature02081. ieee: D. Reinhardt et al., “Regulation of phyllotaxis by polar auxin transport,” Nature, vol. 426, no. 6964. Nature Publishing Group, pp. 255–260, 2003. ista: Reinhardt D, Pesce E, Stieger P, Mandel T, Baltensperger K, Bennett M, Traas J, Friml J, Kuhlemeier C. 2003. Regulation of phyllotaxis by polar auxin transport. Nature. 426(6964), 255–260. mla: Reinhardt, Didier, et al. “Regulation of Phyllotaxis by Polar Auxin Transport.” Nature, vol. 426, no. 6964, Nature Publishing Group, 2003, pp. 255–60, doi:10.1038/nature02081. short: D. Reinhardt, E. Pesce, P. Stieger, T. Mandel, K. Baltensperger, M. Bennett, J. Traas, J. Friml, C. Kuhlemeier, Nature 426 (2003) 255–260. date_created: 2018-12-11T12:00:45Z date_published: 2003-11-20T00:00:00Z date_updated: 2021-01-12T07:40:18Z day: '20' doi: 10.1038/nature02081 extern: 1 intvolume: ' 426' issue: '6964' month: '11' page: 255 - 260 publication: Nature publication_status: published publisher: Nature Publishing Group publist_id: '3707' quality_controlled: 0 status: public title: Regulation of phyllotaxis by polar auxin transport type: journal_article volume: 426 year: '2003' ... --- _id: '2993' abstract: - lang: eng text: Plant biology is currently experiencing a growing demand for easy and reliable mRNA and protein localisation techniques. Here, we present novel whole mount in situ hybridisation and immunolocalisation protocols, suitable to localise mRNAs and proteins in Arabidopsis seedlings. We demonstrate that these methods can be used in different organs of Arabidopsis seedlings as well as in other plant species. In order to achieve better reproducibility and higher throughput, we modified these protocols for automation to be performed by a liquid handling robot. In addition, we show that other procedures such as reporter enzyme assays and tissue clearing can be similarly automated. We present examples of application of our protocols including mRNA localisation and proteins and epitope tag (co)localisations which demonstrate that these methods provide reliable and versatile tools for expression, localisation and anatomical studies in plants. author: - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Eva full_name: Eva Benková id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Ulrike full_name: Mayer, Ulrike last_name: Mayer - first_name: Klaus full_name: Palme, Klaus last_name: Palme - first_name: Gerhard full_name: Muster, Gerhard last_name: Muster citation: ama: Friml J, Benková E, Mayer U, Palme K, Muster G. Automated whole mount localisation techniques for plant seedlings. Plant Journal. 2003;34(1):115-124. doi:10.1046/j.1365-313X.2003.01705.x apa: Friml, J., Benková, E., Mayer, U., Palme, K., & Muster, G. (2003). Automated whole mount localisation techniques for plant seedlings. Plant Journal. Wiley-Blackwell. https://doi.org/10.1046/j.1365-313X.2003.01705.x chicago: Friml, Jiří, Eva Benková, Ulrike Mayer, Klaus Palme, and Gerhard Muster. “Automated Whole Mount Localisation Techniques for Plant Seedlings.” Plant Journal. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1365-313X.2003.01705.x. ieee: J. Friml, E. Benková, U. Mayer, K. Palme, and G. Muster, “Automated whole mount localisation techniques for plant seedlings,” Plant Journal, vol. 34, no. 1. Wiley-Blackwell, pp. 115–124, 2003. ista: Friml J, Benková E, Mayer U, Palme K, Muster G. 2003. Automated whole mount localisation techniques for plant seedlings. Plant Journal. 34(1), 115–124. mla: Friml, Jiří, et al. “Automated Whole Mount Localisation Techniques for Plant Seedlings.” Plant Journal, vol. 34, no. 1, Wiley-Blackwell, 2003, pp. 115–24, doi:10.1046/j.1365-313X.2003.01705.x. short: J. Friml, E. Benková, U. Mayer, K. Palme, G. Muster, Plant Journal 34 (2003) 115–124. date_created: 2018-12-11T12:00:44Z date_published: 2003-04-01T00:00:00Z date_updated: 2021-01-12T07:40:18Z day: '01' doi: 10.1046/j.1365-313X.2003.01705.x extern: 1 intvolume: ' 34' issue: '1' month: '04' page: 115 - 124 publication: Plant Journal publication_status: published publisher: Wiley-Blackwell publist_id: '3709' quality_controlled: 0 status: public title: Automated whole mount localisation techniques for plant seedlings type: journal_article volume: 34 year: '2003' ... --- _id: '3151' abstract: - lang: eng text: Biosynthesis of most peptide hormones and neuropeptides requires proteolytic excision of the active peptide from inactive proprotein precursors, an activity carried out by subtilisin-like proprotein convertases (SPCs) in constitutive or regulated secretory pathways. The Drosophila amontillado (amon) gene encodes a homolog of the mammalian PC2 protein, an SPC that functions in the regulated secretory pathway in neuroendocrine tissues. We have identified amon mutants by isolating ethylmethanesulfonate (EMS)-induced lethal and visible mutations that define two complementation groups in the amon interval at 97D1 of the third chromosome. DNA sequencing identified the amon complementation group and the DNA sequence change for each of the nine amon alleles isolated. amon mutants display partial embryonic lethality, are defective in larval growth, and arrest during the first to second instar larval molt. Mutant larvae can be rescued by heat-shock-induced expression of the amon protein. Rescued larvae arrest at the subsequent larval molt, suggesting that amon is also required for the second to third instar larval molt. Our data indicate that the amon proprotein convertase is required during embryogenesis and larval development in Drosophila and support the hypothesis that AMON acts to proteolytically process peptide hormones that regulate hatching, larval growth, and larval ecdysis. author: - first_name: Lowell full_name: Rayburn, Lowell Y last_name: Rayburn - first_name: Holly full_name: Gooding, Holly C last_name: Gooding - first_name: Semil full_name: Choksi, Semil P last_name: Choksi - first_name: Dhea full_name: Maloney, Dhea last_name: Maloney - first_name: Ambrose full_name: Kidd, Ambrose R last_name: Kidd - first_name: Daria E full_name: Daria Siekhaus id: 3D224B9E-F248-11E8-B48F-1D18A9856A87 last_name: Siekhaus orcid: 0000-0001-8323-8353 - first_name: Michael full_name: Bender, Michael last_name: Bender citation: ama: Rayburn L, Gooding H, Choksi S, et al. Amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. 2003;163(1):227-237. apa: Rayburn, L., Gooding, H., Choksi, S., Maloney, D., Kidd, A., Siekhaus, D. E., & Bender, M. (2003). Amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. Genetics Society of America. chicago: Rayburn, Lowell, Holly Gooding, Semil Choksi, Dhea Maloney, Ambrose Kidd, Daria E Siekhaus, and Michael Bender. “Amontillado, the Drosophila Homolog of the Prohormone Processing Protease PC2, Is Required during Embryogenesis and Early Larval Development.” Genetics. Genetics Society of America, 2003. ieee: L. Rayburn et al., “Amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development,” Genetics, vol. 163, no. 1. Genetics Society of America, pp. 227–237, 2003. ista: Rayburn L, Gooding H, Choksi S, Maloney D, Kidd A, Siekhaus DE, Bender M. 2003. Amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Genetics. 163(1), 227–237. mla: Rayburn, Lowell, et al. “Amontillado, the Drosophila Homolog of the Prohormone Processing Protease PC2, Is Required during Embryogenesis and Early Larval Development.” Genetics, vol. 163, no. 1, Genetics Society of America, 2003, pp. 227–37. short: L. Rayburn, H. Gooding, S. Choksi, D. Maloney, A. Kidd, D.E. Siekhaus, M. Bender, Genetics 163 (2003) 227–237. date_created: 2018-12-11T12:01:41Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:41:25Z day: '01' extern: 1 intvolume: ' 163' issue: '1' month: '01' page: 227 - 237 publication: Genetics publication_status: published publisher: Genetics Society of America publist_id: '3545' quality_controlled: 0 status: public title: Amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development type: journal_article volume: 163 year: '2003' ... --- _id: '3150' abstract: - lang: eng text: Tripartite G-protein-coupled receptors (GPCRs) represent one of the largest groups of signal transducers, transmitting signals from hormones, neuropeptides, odorants, food and light. Ligand-bound receptors catalyse GDP/GTP exchange on the G-protein α-subunit (Gα), leading to α-GTP separation from the βγ subunits and pathway activation. Activating mutations in the receptors or G proteins underlie many human diseases, including some cancers, dwarfism and premature puberty. Regulators of G-protein signalling (RGS proteins) are known to modulate the level and duration of ligand-induced signalling by accelerating the intrinsic GTPase activity of the Gα subunit, and thus reformation of the inactive GDP-bound Gα. Here we find that even in the absence of receptor, mutation of the RGS family member Sst2 (refs 6-9) permits spontaneous activation of the G-protein-coupled mating pathway in Saccharomyces cerevisiae at levels normally seen only in the presence of ligand. Our work demonstrates the occurence of spontaneous tripartite G-protein signalling in vivo and identifies a requirement for RGS proteins in preventing such receptor-independent activation. author: - first_name: Daria E full_name: Daria Siekhaus id: 3D224B9E-F248-11E8-B48F-1D18A9856A87 last_name: Siekhaus orcid: 0000-0001-8323-8353 - first_name: David full_name: Drubin, David G last_name: Drubin citation: ama: Siekhaus DE, Drubin D. Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nature Cell Biology. 2003;5(3):231-235. doi:10.1038/ncb941 apa: Siekhaus, D. E., & Drubin, D. (2003). Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/ncb941 chicago: Siekhaus, Daria E, and David Drubin. “Spontaneous Receptor-Independent Heterotrimeric G-Protein Signalling in an RGS Mutant.” Nature Cell Biology. Nature Publishing Group, 2003. https://doi.org/10.1038/ncb941. ieee: D. E. Siekhaus and D. Drubin, “Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant,” Nature Cell Biology, vol. 5, no. 3. Nature Publishing Group, pp. 231–235, 2003. ista: Siekhaus DE, Drubin D. 2003. Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant. Nature Cell Biology. 5(3), 231–235. mla: Siekhaus, Daria E., and David Drubin. “Spontaneous Receptor-Independent Heterotrimeric G-Protein Signalling in an RGS Mutant.” Nature Cell Biology, vol. 5, no. 3, Nature Publishing Group, 2003, pp. 231–35, doi:10.1038/ncb941. short: D.E. Siekhaus, D. Drubin, Nature Cell Biology 5 (2003) 231–235. date_created: 2018-12-11T12:01:41Z date_published: 2003-03-01T00:00:00Z date_updated: 2021-01-12T07:41:24Z day: '01' doi: 10.1038/ncb941 extern: 1 intvolume: ' 5' issue: '3' month: '03' page: 231 - 235 publication: Nature Cell Biology publication_status: published publisher: Nature Publishing Group publist_id: '3544' quality_controlled: 0 status: public title: Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant type: journal_article volume: 5 year: '2003' ... --- _id: '3209' abstract: - lang: eng text: We show that the fixed alphabet shortest common supersequence (SCS) and the fixed alphabet longest common subsequence (LCS) problems parameterized in the number of strings are W[1]-hard. Unless W[1]=FPT, this rules out the existence of algorithms with time complexity of O(f(k)nα) for those problems. Here n is the size of the problem instance, α is constant, k is the number of strings and f is any function of k. The fixed alphabet version of the LCS problem is of particular interest considering the importance of sequence comparison (e.g. multiple sequence alignment) in the fixed length alphabet world of DNA and protein sequences. author: - first_name: Krzysztof Z full_name: Krzysztof Pietrzak id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 citation: ama: Pietrzak KZ. On the parameterized complexity of the fixed alphabet shortest common supersequence and longest common subsequence problems. Journal of Computer and System Sciences. 2003;67(4):757-771. doi:10.1016/S0022-0000(03)00078-3 apa: Pietrzak, K. Z. (2003). On the parameterized complexity of the fixed alphabet shortest common supersequence and longest common subsequence problems. Journal of Computer and System Sciences. Elsevier. https://doi.org/10.1016/S0022-0000(03)00078-3 chicago: Pietrzak, Krzysztof Z. “On the Parameterized Complexity of the Fixed Alphabet Shortest Common Supersequence and Longest Common Subsequence Problems.” Journal of Computer and System Sciences. Elsevier, 2003. https://doi.org/10.1016/S0022-0000(03)00078-3. ieee: K. Z. Pietrzak, “On the parameterized complexity of the fixed alphabet shortest common supersequence and longest common subsequence problems,” Journal of Computer and System Sciences, vol. 67, no. 4. Elsevier, pp. 757–771, 2003. ista: Pietrzak KZ. 2003. On the parameterized complexity of the fixed alphabet shortest common supersequence and longest common subsequence problems. Journal of Computer and System Sciences. 67(4), 757–771. mla: Pietrzak, Krzysztof Z. “On the Parameterized Complexity of the Fixed Alphabet Shortest Common Supersequence and Longest Common Subsequence Problems.” Journal of Computer and System Sciences, vol. 67, no. 4, Elsevier, 2003, pp. 757–71, doi:10.1016/S0022-0000(03)00078-3. short: K.Z. Pietrzak, Journal of Computer and System Sciences 67 (2003) 757–771. date_created: 2018-12-11T12:02:01Z date_published: 2003-12-01T00:00:00Z date_updated: 2021-01-12T07:41:49Z day: '01' doi: 10.1016/S0022-0000(03)00078-3 extern: 1 intvolume: ' 67' issue: '4' month: '12' page: 757 - 771 publication: Journal of Computer and System Sciences publication_status: published publisher: Elsevier publist_id: '3472' quality_controlled: 0 status: public title: On the parameterized complexity of the fixed alphabet shortest common supersequence and longest common subsequence problems type: journal_article volume: 67 year: '2003' ... --- _id: '3210' abstract: - lang: eng text: 'Luby and Rackoff showed how to construct a (super-)pseudo-random permutation {0,1}2n→ {0,1}2n from some number r of pseudo-random functions {0,1}n → {0,1}n. Their construction, motivated by DES, consists of a cascade of r Feistel permutations. A Feistel permutation 1for a pseudo-random function f is defined as (L, R) → (R,L ⊕ f (R)), where L and R are the left and right part of the input and ⊕ denotes bitwise XOR or, in this paper, any other group operation on {0,1}n. The only non-trivial step of the security proof consists of proving that the cascade of r Feistel permutations with independent uniform random functions {0,1}n → {0,1}n, denoted Ψ2nr is indistinguishable from a uniform random permutation {0,1}2n → {0,1}2n by any computationally unbounded adaptive distinguisher making at most O(2cn) combined chosen plaintext/ciphertext queries for any c < α, where a is a security parameter. Luby and Rackoff proved α = 1/2 for r = 4. A natural problem, proposed by Pieprzyk is to improve on α for larger r. The best known result, α = 3/4 for r = 6, is due to Patarin. In this paper we prove a = 1 -O(1/r), i.e., the trivial upper bound α = 1 can be approached. The proof uses some new techniques that can be of independent interest. ' alternative_title: - LNCS author: - first_name: Ueli full_name: Maurer, Ueli M last_name: Maurer - first_name: Krzysztof Z full_name: Krzysztof Pietrzak id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 citation: ama: 'Maurer U, Pietrzak KZ. The security of many round Luby Rackoff pseudo random permutations. In: Vol 2656. Springer; 2003:544-561. doi:10.1007/3-540-39200-9_34' apa: 'Maurer, U., & Pietrzak, K. Z. (2003). The security of many round Luby Rackoff pseudo random permutations (Vol. 2656, pp. 544–561). Presented at the EUROCRYPT: Theory and Applications of Cryptographic Techniques, Springer. https://doi.org/10.1007/3-540-39200-9_34' chicago: Maurer, Ueli, and Krzysztof Z Pietrzak. “The Security of Many Round Luby Rackoff Pseudo Random Permutations,” 2656:544–61. Springer, 2003. https://doi.org/10.1007/3-540-39200-9_34. ieee: 'U. Maurer and K. Z. Pietrzak, “The security of many round Luby Rackoff pseudo random permutations,” presented at the EUROCRYPT: Theory and Applications of Cryptographic Techniques, 2003, vol. 2656, pp. 544–561.' ista: 'Maurer U, Pietrzak KZ. 2003. The security of many round Luby Rackoff pseudo random permutations. EUROCRYPT: Theory and Applications of Cryptographic Techniques, LNCS, vol. 2656, 544–561.' mla: Maurer, Ueli, and Krzysztof Z. Pietrzak. The Security of Many Round Luby Rackoff Pseudo Random Permutations. Vol. 2656, Springer, 2003, pp. 544–61, doi:10.1007/3-540-39200-9_34. short: U. Maurer, K.Z. Pietrzak, in:, Springer, 2003, pp. 544–561. conference: name: 'EUROCRYPT: Theory and Applications of Cryptographic Techniques' date_created: 2018-12-11T12:02:02Z date_published: 2003-06-04T00:00:00Z date_updated: 2021-01-12T07:41:49Z day: '04' doi: 10.1007/3-540-39200-9_34 extern: 1 intvolume: ' 2656' month: '06' page: 544 - 561 publication_status: published publisher: Springer publist_id: '3473' quality_controlled: 0 status: public title: The security of many round Luby Rackoff pseudo random permutations type: conference volume: 2656 year: '2003' ... --- _id: '3425' alternative_title: - Nato Science Series II article_processing_charge: No author: - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X - first_name: T. full_name: Strother, T. last_name: Strother - first_name: Wolfgang full_name: Bauer, Wolfgang last_name: Bauer citation: ama: 'Bollenbach MT, Strother T, Bauer W. 3D supernova collapse calculations. In: Vol 166. Springer; 2003:277-288. doi:10.1007/978-1-4020-2705-5_21' apa: Bollenbach, M. T., Strother, T., & Bauer, W. (2003). 3D supernova collapse calculations (Vol. 166, pp. 277–288). Presented at the NATO ASI on Structure and Dynamics of Elementary Matter, Springer. https://doi.org/10.1007/978-1-4020-2705-5_21 chicago: Bollenbach, Mark Tobias, T. Strother, and Wolfgang Bauer. “3D Supernova Collapse Calculations,” 166:277–88. Springer, 2003. https://doi.org/10.1007/978-1-4020-2705-5_21. ieee: M. T. Bollenbach, T. Strother, and W. Bauer, “3D supernova collapse calculations,” presented at the NATO ASI on Structure and Dynamics of Elementary Matter, 2003, vol. 166, pp. 277–288. ista: Bollenbach MT, Strother T, Bauer W. 2003. 3D supernova collapse calculations. NATO ASI on Structure and Dynamics of Elementary Matter, Nato Science Series II, vol. 166, 277–288. mla: Bollenbach, Mark Tobias, et al. 3D Supernova Collapse Calculations. Vol. 166, Springer, 2003, pp. 277–88, doi:10.1007/978-1-4020-2705-5_21. short: M.T. Bollenbach, T. Strother, W. Bauer, in:, Springer, 2003, pp. 277–288. conference: name: NATO ASI on Structure and Dynamics of Elementary Matter date_created: 2018-12-11T12:03:16Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:43:23Z day: '01' doi: 10.1007/978-1-4020-2705-5_21 extern: '1' intvolume: ' 166' language: - iso: eng month: '01' oa_version: None page: 277 - 288 publication_status: published publisher: Springer publist_id: '2976' status: public title: 3D supernova collapse calculations type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 166 year: '2003' ... --- _id: '3458' author: - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Klaus full_name: Unsicker, Klaus last_name: Unsicker citation: ama: 'Jonas PM, Unsicker K. Molekulare und zelluläre Grundlagen des Nervensystems. In: Schmidt R, ed. Lehrbuch Vorklinik. Vol B. Deutscher Ärzte Verlag; 2003:3-26.' apa: Jonas, P. M., & Unsicker, K. (2003). Molekulare und zelluläre Grundlagen des Nervensystems. In R. Schmidt (Ed.), Lehrbuch Vorklinik (Vol. B, pp. 3–26). Deutscher Ärzte Verlag. chicago: Jonas, Peter M, and Klaus Unsicker. “Molekulare Und Zelluläre Grundlagen Des Nervensystems.” In Lehrbuch Vorklinik, edited by R. Schmidt, B:3–26. Deutscher Ärzte Verlag, 2003. ieee: P. M. Jonas and K. Unsicker, “Molekulare und zelluläre Grundlagen des Nervensystems.,” in Lehrbuch Vorklinik, vol. B, R. Schmidt, Ed. Deutscher Ärzte Verlag, 2003, pp. 3–26. ista: 'Jonas PM, Unsicker K. 2003.Molekulare und zelluläre Grundlagen des Nervensystems. In: Lehrbuch Vorklinik. vol. B, 3–26.' mla: Jonas, Peter M., and Klaus Unsicker. “Molekulare Und Zelluläre Grundlagen Des Nervensystems.” Lehrbuch Vorklinik, edited by R. Schmidt, vol. B, Deutscher Ärzte Verlag, 2003, pp. 3–26. short: P.M. Jonas, K. Unsicker, in:, R. Schmidt (Ed.), Lehrbuch Vorklinik, Deutscher Ärzte Verlag, 2003, pp. 3–26. date_created: 2018-12-11T12:03:26Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:43:35Z day: '01' editor: - first_name: R. full_name: Schmidt, R. F. last_name: Schmidt extern: 1 month: '01' page: 3 - 26 publication: Lehrbuch Vorklinik publication_status: published publisher: Deutscher Ärzte Verlag publist_id: '2929' quality_controlled: 0 status: public title: Molekulare und zelluläre Grundlagen des Nervensystems. type: book_chapter volume: B year: '2003' ... --- _id: '3536' abstract: - lang: eng text: 'Genetic engineering of the mouse brain allows investigators to address novel hypotheses in vivo. Because of the paucity of information on the network patterns of the mouse hippocampus, we investigated the electrical patterns in the behaving animal using multisite silicon probes and wire tetrodes. Theta (6-9 Hz) and gamma (40-100 Hz) oscillations were present during exploration and rapid eye movement sleep. Gamma power and theta power were comodulated and gamma power varied as a function of the theta cycle. Pyramidal cells and putative interneurons were phase-locked to theta oscillations. During immobility, consummatory behaviors and slow-wave sleep, sharp waves were present in cornu ammonis region CA1 of the hippocampus stratum radiatum associated with 140-200-Hz “ripples” in the pyramidal cell layer and population burst of CA1 neurons. In the hilus, large-amplitude “dentate spikes” occurred in association with increased discharge of hilar neurons. The amplitude of field patterns was larger in the mouse than in the rat, likely reflecting the higher neuron density in a smaller brain. We suggest that the main hippocampal network patterns are mediated by similar pathways and mechanisms in mouse and rat. ' author: - first_name: György full_name: Buzsáki, György last_name: Buzsáki - first_name: Derek full_name: Buhl, Derek L last_name: Buhl - first_name: Kenneth full_name: Harris, Kenneth D last_name: Harris - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Boldizsár full_name: Czéh, Boldizsár last_name: Czéh - first_name: Alexei full_name: Morozov, Alexei last_name: Morozov citation: ama: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. Hippocampal network patterns of activity in the mouse. Neuroscience. 2003;116(1):201-211. doi:10.1016/S0306-4522(02)00669-3 apa: Buzsáki, G., Buhl, D., Harris, K., Csicsvari, J. L., Czéh, B., & Morozov, A. (2003). Hippocampal network patterns of activity in the mouse. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(02)00669-3 chicago: Buzsáki, György, Derek Buhl, Kenneth Harris, Jozsef L Csicsvari, Boldizsár Czéh, and Alexei Morozov. “Hippocampal Network Patterns of Activity in the Mouse.” Neuroscience. Elsevier, 2003. https://doi.org/10.1016/S0306-4522(02)00669-3. ieee: G. Buzsáki, D. Buhl, K. Harris, J. L. Csicsvari, B. Czéh, and A. Morozov, “Hippocampal network patterns of activity in the mouse,” Neuroscience, vol. 116, no. 1. Elsevier, pp. 201–211, 2003. ista: Buzsáki G, Buhl D, Harris K, Csicsvari JL, Czéh B, Morozov A. 2003. Hippocampal network patterns of activity in the mouse. Neuroscience. 116(1), 201–211. mla: Buzsáki, György, et al. “Hippocampal Network Patterns of Activity in the Mouse.” Neuroscience, vol. 116, no. 1, Elsevier, 2003, pp. 201–11, doi:10.1016/S0306-4522(02)00669-3. short: G. Buzsáki, D. Buhl, K. Harris, J.L. Csicsvari, B. Czéh, A. Morozov, Neuroscience 116 (2003) 201–211. date_created: 2018-12-11T12:03:50Z date_published: 2003-01-15T00:00:00Z date_updated: 2021-01-12T07:44:09Z day: '15' doi: 10.1016/S0306-4522(02)00669-3 extern: 1 intvolume: ' 116' issue: '1' month: '01' page: 201 - 211 publication: Neuroscience publication_status: published publisher: Elsevier publist_id: '2849' quality_controlled: 0 status: public title: Hippocampal network patterns of activity in the mouse type: journal_article volume: 116 year: '2003' ... --- _id: '3556' abstract: - lang: eng text: We define the Morse-Smale complex of a Morse function over a 3-manifold as the overlay of the descending and as- cending manifolds of all critical points. In the generic case, its 3-dimensional cells are shaped like crystals and are sepa- rated by quadrangular faces. In this paper, we give a combi- natorial algorithm for constructing such complexes for piece- wise linear data. author: - first_name: Herbert full_name: Herbert Edelsbrunner id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: John full_name: Harer, John last_name: Harer - first_name: Vijay full_name: Natarajan, Vijay last_name: Natarajan - first_name: Valerio full_name: Pascucci, Valerio last_name: Pascucci citation: ama: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Morse-Smale complexes for piecewise linear 3-manifolds. In: ACM; 2003:361-370. doi:10.1145/777792.777846' apa: 'Edelsbrunner, H., Harer, J., Natarajan, V., & Pascucci, V. (2003). Morse-Smale complexes for piecewise linear 3-manifolds (pp. 361–370). Presented at the SCG: Symposium on Computational Geometry, ACM. https://doi.org/10.1145/777792.777846' chicago: Edelsbrunner, Herbert, John Harer, Vijay Natarajan, and Valerio Pascucci. “Morse-Smale Complexes for Piecewise Linear 3-Manifolds,” 361–70. ACM, 2003. https://doi.org/10.1145/777792.777846. ieee: 'H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci, “Morse-Smale complexes for piecewise linear 3-manifolds,” presented at the SCG: Symposium on Computational Geometry, 2003, pp. 361–370.' ista: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2003. Morse-Smale complexes for piecewise linear 3-manifolds. SCG: Symposium on Computational Geometry, 361–370.' mla: Edelsbrunner, Herbert, et al. Morse-Smale Complexes for Piecewise Linear 3-Manifolds. ACM, 2003, pp. 361–70, doi:10.1145/777792.777846. short: H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci, in:, ACM, 2003, pp. 361–370. conference: name: 'SCG: Symposium on Computational Geometry' date_created: 2018-12-11T12:03:57Z date_published: 2003-06-01T00:00:00Z date_updated: 2021-01-12T07:44:17Z day: '01' doi: 10.1145/777792.777846 extern: 1 main_file_link: - open_access: '0' url: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.14.9592 month: '06' page: 361 - 370 publication_status: published publisher: ACM publist_id: '2829' quality_controlled: 0 status: public title: Morse-Smale complexes for piecewise linear 3-manifolds type: conference year: '2003' ... --- _id: '3573' abstract: - lang: eng text: Given a finite point set in R, the surface reconstruction problem asks for a surface that passes through many but not necessarily all points. We describe an unambigu- ous definition of such a surface in geometric and topological terms, and sketch a fast algorithm for constructing it. Our solution overcomes past limitations to special point distributions and heuristic design decisions. author: - first_name: Herbert full_name: Herbert Edelsbrunner id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: 'Edelsbrunner H. Surface reconstruction by wrapping finite sets in space. In: Discrete & Computational Geometry. Springer; 2003:379-404. doi:10.1007/978-3-642-55566-4_17' apa: Edelsbrunner, H. (2003). Surface reconstruction by wrapping finite sets in space. In Discrete & Computational Geometry (pp. 379–404). Springer. https://doi.org/10.1007/978-3-642-55566-4_17 chicago: Edelsbrunner, Herbert. “Surface Reconstruction by Wrapping Finite Sets in Space.” In Discrete & Computational Geometry, 379–404. Springer, 2003. https://doi.org/10.1007/978-3-642-55566-4_17. ieee: H. Edelsbrunner, “Surface reconstruction by wrapping finite sets in space,” in Discrete & Computational Geometry, Springer, 2003, pp. 379–404. ista: 'Edelsbrunner H. 2003.Surface reconstruction by wrapping finite sets in space. In: Discrete & Computational Geometry. , 379–404.' mla: Edelsbrunner, Herbert. “Surface Reconstruction by Wrapping Finite Sets in Space.” Discrete & Computational Geometry, Springer, 2003, pp. 379–404, doi:10.1007/978-3-642-55566-4_17. short: H. Edelsbrunner, in:, Discrete & Computational Geometry, Springer, 2003, pp. 379–404. date_created: 2018-12-11T12:04:02Z date_published: 2003-06-23T00:00:00Z date_updated: 2021-01-12T07:44:24Z day: '23' doi: 10.1007/978-3-642-55566-4_17 extern: 1 main_file_link: - open_access: '0' url: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.129.3633 month: '06' page: 379 - 404 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '2812' quality_controlled: 0 status: public title: Surface reconstruction by wrapping finite sets in space type: book_chapter year: '2003' ... --- _id: '3584' abstract: - lang: eng text: We develop fast algorithms for computing the linking number of a simplicial complex within a filtration.We give experimental results in applying our work toward the detection of non-trivial tangling in biomolecules, modeled as alpha complexes. author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Afra full_name: Zomorodian, Afra last_name: Zomorodian citation: ama: Edelsbrunner H, Zomorodian A. Computing linking numbers of a filtration. Homology, Homotopy and Applications. 2003;5(2):19-37. apa: Edelsbrunner, H., & Zomorodian, A. (2003). Computing linking numbers of a filtration. Homology, Homotopy and Applications. International Press. chicago: Edelsbrunner, Herbert, and Afra Zomorodian. “Computing Linking Numbers of a Filtration.” Homology, Homotopy and Applications. International Press, 2003. ieee: H. Edelsbrunner and A. Zomorodian, “Computing linking numbers of a filtration,” Homology, Homotopy and Applications, vol. 5, no. 2. International Press, pp. 19–37, 2003. ista: Edelsbrunner H, Zomorodian A. 2003. Computing linking numbers of a filtration. Homology, Homotopy and Applications. 5(2), 19–37. mla: Edelsbrunner, Herbert, and Afra Zomorodian. “Computing Linking Numbers of a Filtration.” Homology, Homotopy and Applications, vol. 5, no. 2, International Press, 2003, pp. 19–37. short: H. Edelsbrunner, A. Zomorodian, Homology, Homotopy and Applications 5 (2003) 19–37. date_created: 2018-12-11T12:04:05Z date_published: 2003-04-22T00:00:00Z date_updated: 2021-01-12T07:44:28Z day: '22' extern: '1' intvolume: ' 5' issue: '2' language: - iso: eng main_file_link: - url: http://projecteuclid.org/euclid.hha/1088453320 month: '04' oa_version: None page: 19 - 37 publication: Homology, Homotopy and Applications publication_status: published publisher: International Press publist_id: '2801' quality_controlled: '1' status: public title: Computing linking numbers of a filtration type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 5 year: '2003' ... --- _id: '3620' abstract: - lang: eng text: 'Stable hybrid zones in which ecologically divergent taxa give rise to a range of recombinants are natural laboratories in which the genetic basis of adaptation and reproductive isolation can be unraveled. One such hybrid zone is formed by the fire-bellied toads Bombina bombina and B. variegata (Anura: Discoglossidae). Adaptations to permanent and ephemeral breeding habitats, respectively, have shaped numerous phenotypic differences between the taxa. All of these are, in principle, candidates for a genetic dissection via QTL mapping. We present here a linkage map of 28 codominant and 10 dominant markers in the Bombina genome. In an F2 cross, markers that were mainly microsatellites, SSCPs or allozymes were mapped to 20 linkage groups. Among the 40 isolated CA microsatellites, we noted a preponderance of compound and frequently interleaved CA-TA repeats as well as a striking polarity at the 5′ end of the repeats.' author: - first_name: Beate full_name: Nürnberger, Beate last_name: Nürnberger - first_name: Sebastian full_name: Hofman, Sebastian last_name: Hofman - first_name: Bqruni full_name: Förg-Brey, Bqruni last_name: Förg Brey - first_name: Gabriele full_name: Praetzel, Gabriele last_name: Praetzel - first_name: Alan full_name: Maclean, Alan W last_name: Maclean - first_name: Jacek full_name: Szymura, Jacek M last_name: Szymura - first_name: Catherine full_name: Abbott, Catherine M last_name: Abbott - first_name: Nicholas H full_name: Nicholas Barton id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: 'Nürnberger B, Hofman S, Förg Brey B, et al. A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae). Heredity. 2003;91(2):136-142. doi:10.1038/sj.hdy.6800291' apa: 'Nürnberger, B., Hofman, S., Förg Brey, B., Praetzel, G., Maclean, A., Szymura, J., … Barton, N. H. (2003). A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae). Heredity. Nature Publishing Group. https://doi.org/10.1038/sj.hdy.6800291' chicago: 'Nürnberger, Beate, Sebastian Hofman, Bqruni Förg Brey, Gabriele Praetzel, Alan Maclean, Jacek Szymura, Catherine Abbott, and Nicholas H Barton. “A Linkage Map for the Hybridising Toads Bombina Bombina and B. Variegata (Anura: Discoglossidae).” Heredity. Nature Publishing Group, 2003. https://doi.org/10.1038/sj.hdy.6800291.' ieee: 'B. Nürnberger et al., “A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae),” Heredity, vol. 91, no. 2. Nature Publishing Group, pp. 136–142, 2003.' ista: 'Nürnberger B, Hofman S, Förg Brey B, Praetzel G, Maclean A, Szymura J, Abbott C, Barton NH. 2003. A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae). Heredity. 91(2), 136–142.' mla: 'Nürnberger, Beate, et al. “A Linkage Map for the Hybridising Toads Bombina Bombina and B. Variegata (Anura: Discoglossidae).” Heredity, vol. 91, no. 2, Nature Publishing Group, 2003, pp. 136–42, doi:10.1038/sj.hdy.6800291.' short: B. Nürnberger, S. Hofman, B. Förg Brey, G. Praetzel, A. Maclean, J. Szymura, C. Abbott, N.H. Barton, Heredity 91 (2003) 136–142. date_created: 2018-12-11T12:04:17Z date_published: 2003-08-01T00:00:00Z date_updated: 2021-01-12T07:44:43Z day: '01' doi: 10.1038/sj.hdy.6800291 extern: 1 intvolume: ' 91' issue: '2' month: '08' page: 136 - 142 publication: Heredity publication_status: published publisher: Nature Publishing Group publist_id: '2763' quality_controlled: 0 status: public title: 'A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae)' type: journal_article volume: 91 year: '2003' ... --- _id: '3619' abstract: - lang: eng text: What is the chance that some part of a stretch of genome will survive? In a population of constant size, and with no selection, the probability of survival of some part of a stretch of map length y<1 approaches View the MathML source for View the MathML source. Thus, the whole genome is certain to be lost, but the rate of loss is extremely slow. This solution extends to give the whole distribution of surviving block sizes as a function of time. We show that the expected number of blocks at time t is 1+yt and give expressions for the moments of the number of blocks and the total amount of genome that survives for a given time. The solution is based on a branching process and assumes complete interference between crossovers, so that each descendant carries only a single block of ancestral material. We consider cases where most individuals carry multiple blocks, either because there are multiple crossovers in a long genetic map, or because enough time has passed that most individuals in the population are related to each other. For species such as ours, which have a long genetic map, the genome of any individual which leaves descendants (∼80% of the population for a Poisson offspring number with mean two) is likely to persist for an extremely long time, in the form of a few short blocks of genome. author: - first_name: Stuart full_name: Baird, Stuart J last_name: Baird - first_name: Nicholas H full_name: Nicholas Barton id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Alison full_name: Etheridge, Alison M last_name: Etheridge citation: ama: Baird S, Barton NH, Etheridge A. The distribution of surviving blocks of an ancestral genome. Theoretical Population Biology. 2003;64(4):451-471. doi:10.1016/S0040-5809(03)00098-4 apa: Baird, S., Barton, N. H., & Etheridge, A. (2003). The distribution of surviving blocks of an ancestral genome. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/S0040-5809(03)00098-4 chicago: Baird, Stuart, Nicholas H Barton, and Alison Etheridge. “The Distribution of Surviving Blocks of an Ancestral Genome.” Theoretical Population Biology. Academic Press, 2003. https://doi.org/10.1016/S0040-5809(03)00098-4. ieee: S. Baird, N. H. Barton, and A. Etheridge, “The distribution of surviving blocks of an ancestral genome,” Theoretical Population Biology, vol. 64, no. 4. Academic Press, pp. 451–471, 2003. ista: Baird S, Barton NH, Etheridge A. 2003. The distribution of surviving blocks of an ancestral genome. Theoretical Population Biology. 64(4), 451–471. mla: Baird, Stuart, et al. “The Distribution of Surviving Blocks of an Ancestral Genome.” Theoretical Population Biology, vol. 64, no. 4, Academic Press, 2003, pp. 451–71, doi:10.1016/S0040-5809(03)00098-4. short: S. Baird, N.H. Barton, A. Etheridge, Theoretical Population Biology 64 (2003) 451–471. date_created: 2018-12-11T12:04:17Z date_published: 2003-12-01T00:00:00Z date_updated: 2021-01-12T07:44:42Z day: '01' doi: 10.1016/S0040-5809(03)00098-4 extern: 1 intvolume: ' 64' issue: '4' month: '12' page: 451 - 471 publication: Theoretical Population Biology publication_status: published publisher: Academic Press publist_id: '2764' quality_controlled: 0 status: public title: The distribution of surviving blocks of an ancestral genome type: journal_article volume: 64 year: '2003' ... --- _id: '3618' abstract: - lang: eng text: There are several analyses in evolutionary ecology which assume that a family of offspring has come from only two parents. Here, we present a simple test for detecting when a batch involves two or more subfamilies. It is based on the fact that the mixing of families generates associations amongst unlinked marker loci. We also present simulations illustrating the power of our method for varying numbers of loci, alleles per locus and genotyped individuals. author: - first_name: Timothy full_name: Vines, Timothy H last_name: Vines - first_name: Nicholas H full_name: Nicholas Barton id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Vines T, Barton NH. A new approach to detecting mixed families. Molecular Ecology. 2003;12(7):1999-2002. doi:10.1046/j.1365-294X.2003.01867.x apa: Vines, T., & Barton, N. H. (2003). A new approach to detecting mixed families. Molecular Ecology. Wiley-Blackwell. https://doi.org/10.1046/j.1365-294X.2003.01867.x chicago: Vines, Timothy, and Nicholas H Barton. “A New Approach to Detecting Mixed Families.” Molecular Ecology. Wiley-Blackwell, 2003. https://doi.org/10.1046/j.1365-294X.2003.01867.x. ieee: T. Vines and N. H. Barton, “A new approach to detecting mixed families,” Molecular Ecology, vol. 12, no. 7. Wiley-Blackwell, pp. 1999–2002, 2003. ista: Vines T, Barton NH. 2003. A new approach to detecting mixed families. Molecular Ecology. 12(7), 1999–2002. mla: Vines, Timothy, and Nicholas H. Barton. “A New Approach to Detecting Mixed Families.” Molecular Ecology, vol. 12, no. 7, Wiley-Blackwell, 2003, pp. 1999–2002, doi:10.1046/j.1365-294X.2003.01867.x. short: T. Vines, N.H. Barton, Molecular Ecology 12 (2003) 1999–2002. date_created: 2018-12-11T12:04:16Z date_published: 2003-07-01T00:00:00Z date_updated: 2021-01-12T07:44:42Z day: '01' doi: 10.1046/j.1365-294X.2003.01867.x extern: 1 intvolume: ' 12' issue: '7' month: '07' page: 1999 - 2002 publication: Molecular Ecology publication_status: published publisher: Wiley-Blackwell publist_id: '2765' quality_controlled: 0 status: public title: A new approach to detecting mixed families type: journal_article volume: 12 year: '2003' ... --- _id: '3752' abstract: - lang: eng text: We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system. author: - first_name: Jose full_name: Vilar,Jose M last_name: Vilar - first_name: Calin C full_name: Calin Guet id: 47F8433E-F248-11E8-B48F-1D18A9856A87 last_name: Guet orcid: 0000-0001-6220-2052 - first_name: Stanislas full_name: Leibler, Stanislas last_name: Leibler citation: ama: 'Vilar J, Guet CC, Leibler S. Modeling network dynamics: the lac operon, a case study. Journal of Cell Biology. 2003;161(3):471-476. doi:10.1083/jcb.200301125' apa: 'Vilar, J., Guet, C. C., & Leibler, S. (2003). Modeling network dynamics: the lac operon, a case study. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.200301125' chicago: 'Vilar, Jose, Calin C Guet, and Stanislas Leibler. “Modeling Network Dynamics: The Lac Operon, a Case Study.” Journal of Cell Biology. Rockefeller University Press, 2003. https://doi.org/10.1083/jcb.200301125.' ieee: 'J. Vilar, C. C. Guet, and S. Leibler, “Modeling network dynamics: the lac operon, a case study,” Journal of Cell Biology, vol. 161, no. 3. Rockefeller University Press, pp. 471–476, 2003.' ista: 'Vilar J, Guet CC, Leibler S. 2003. Modeling network dynamics: the lac operon, a case study. Journal of Cell Biology. 161(3), 471–476.' mla: 'Vilar, Jose, et al. “Modeling Network Dynamics: The Lac Operon, a Case Study.” Journal of Cell Biology, vol. 161, no. 3, Rockefeller University Press, 2003, pp. 471–76, doi:10.1083/jcb.200301125.' short: J. Vilar, C.C. Guet, S. Leibler, Journal of Cell Biology 161 (2003) 471–476. date_created: 2018-12-11T12:04:58Z date_published: 2003-01-12T00:00:00Z date_updated: 2021-01-12T07:51:57Z day: '12' doi: 10.1083/jcb.200301125 extern: 1 intvolume: ' 161' issue: '3' main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172934/?tool=pubmed month: '01' oa: 1 page: 471 - 476 publication: Journal of Cell Biology publication_status: published publisher: Rockefeller University Press publist_id: '2475' quality_controlled: 0 status: public title: 'Modeling network dynamics: the lac operon, a case study' type: journal_article volume: 161 year: '2003' ... --- _id: '3797' article_processing_charge: No author: - first_name: Wolfgang full_name: Bauer, Wolfgang last_name: Bauer - first_name: Marco full_name: Kleine Berkenbusch, Marco last_name: Kleine Berkenbusch - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X citation: ama: 'Bauer W, Kleine Berkenbusch M, Bollenbach MT. Breaking atomic nuclei into little pieces: evidence for a phase transition. Revista Mexicana De Fisica. 2003;49(4):1-6.' apa: 'Bauer, W., Kleine Berkenbusch, M., & Bollenbach, M. T. (2003). Breaking atomic nuclei into little pieces: evidence for a phase transition. Revista Mexicana De Fisica. Sociedad Mexicana de Física.' chicago: 'Bauer, Wolfgang, Marco Kleine Berkenbusch, and Mark Tobias Bollenbach. “Breaking Atomic Nuclei into Little Pieces: Evidence for a Phase Transition.” Revista Mexicana De Fisica. Sociedad Mexicana de Física, 2003.' ieee: 'W. Bauer, M. Kleine Berkenbusch, and M. T. Bollenbach, “Breaking atomic nuclei into little pieces: evidence for a phase transition,” Revista Mexicana De Fisica, vol. 49, no. 4. Sociedad Mexicana de Física, pp. 1–6, 2003.' ista: 'Bauer W, Kleine Berkenbusch M, Bollenbach MT. 2003. Breaking atomic nuclei into little pieces: evidence for a phase transition. Revista Mexicana De Fisica. 49(4), 1–6.' mla: 'Bauer, Wolfgang, et al. “Breaking Atomic Nuclei into Little Pieces: Evidence for a Phase Transition.” Revista Mexicana De Fisica, vol. 49, no. 4, Sociedad Mexicana de Física, 2003, pp. 1–6.' short: W. Bauer, M. Kleine Berkenbusch, M.T. Bollenbach, Revista Mexicana De Fisica 49 (2003) 1–6. date_created: 2018-12-11T12:05:13Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:52:16Z day: '01' extern: '1' intvolume: ' 49' issue: '4' language: - iso: eng month: '01' oa_version: None page: 1 - 6 publication: Revista Mexicana De Fisica publication_status: published publisher: Sociedad Mexicana de Física publist_id: '2413' status: public title: 'Breaking atomic nuclei into little pieces: evidence for a phase transition' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 49 year: '2003' ... --- _id: '3897' abstract: - lang: eng text: Many verification, planning, and control problems can be modeled as games played on state-transition graphs by one or two players whose conflicting goals are to form a path in the graph. The focus here is on simple stochastic parity games, that is, two-player games with turn-based probabilistic transitions and omega-regular objectives formalized as parity (Rabin chain) winning conditions. An efficient translation from simple stochastic parity games to nonstochastic parity games is given. As many algorithms are known for solving the latter, the translation yields efficient algorithms for computing the states of a simple stochastic parity game from which a player can win with probability 1. An important special case of simple stochastic parity games are the Markov decision processes with Buchi objectives. For this special case a first provably subquadratic algorithm is given for computing the states from which the single player has a strategy to achieve a Buchi objective with probability 1. For game graphs with m edges the algorithm works in time O(mrootm). Interestingly, a similar technique sheds light on the question of the computational complexity of solving simple Buchi games and yields the first provably subquadratic algorithm, with a running time of O(n(2)/log n) for game graphs with n vertices and O(n) edges. acknowledgement: This research was supported in part by the DARPA grant F33615-C-98-3614, the ONR grant N00014-02-1-0671, the NSF grants CCR-9988172 and CCR-0225610, and the Polish KBN grant 7-T11C-027-20. alternative_title: - LNCS author: - first_name: Krishnendu full_name: Krishnendu Chatterjee id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Marcin full_name: Jurdziński, Marcin last_name: Jurdziński - first_name: Thomas A full_name: Thomas Henzinger id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 citation: ama: 'Chatterjee K, Jurdziński M, Henzinger TA. Simple stochastic parity games. In: Vol 2803. Springer; 2003:100-113. doi:10.1007/978-3-540-45220-1_11' apa: 'Chatterjee, K., Jurdziński, M., & Henzinger, T. A. (2003). Simple stochastic parity games (Vol. 2803, pp. 100–113). Presented at the CSL: Computer Science Logic, Springer. https://doi.org/10.1007/978-3-540-45220-1_11' chicago: Chatterjee, Krishnendu, Marcin Jurdziński, and Thomas A Henzinger. “Simple Stochastic Parity Games,” 2803:100–113. Springer, 2003. https://doi.org/10.1007/978-3-540-45220-1_11. ieee: 'K. Chatterjee, M. Jurdziński, and T. A. Henzinger, “Simple stochastic parity games,” presented at the CSL: Computer Science Logic, 2003, vol. 2803, pp. 100–113.' ista: 'Chatterjee K, Jurdziński M, Henzinger TA. 2003. Simple stochastic parity games. CSL: Computer Science Logic, LNCS, vol. 2803, 100–113.' mla: Chatterjee, Krishnendu, et al. Simple Stochastic Parity Games. Vol. 2803, Springer, 2003, pp. 100–13, doi:10.1007/978-3-540-45220-1_11. short: K. Chatterjee, M. Jurdziński, T.A. Henzinger, in:, Springer, 2003, pp. 100–113. conference: name: 'CSL: Computer Science Logic' date_created: 2018-12-11T12:05:46Z date_published: 2003-08-18T00:00:00Z date_updated: 2021-01-12T07:53:02Z day: '18' doi: 10.1007/978-3-540-45220-1_11 extern: 1 intvolume: ' 2803' month: '08' page: 100 - 113 publication_status: published publisher: Springer publist_id: '2259' quality_controlled: 0 status: public title: Simple stochastic parity games type: conference volume: 2803 year: '2003' ... --- _id: '3898' abstract: - lang: eng text: We study the problem of determining stack boundedness and the exact maximum stack size for three classes of interrupt-driven programs. Interrupt-driven programs axe used in many real-time applications that require responsive interrupt handling. In order to ensure responsiveness, programmers often enable interrupt processing in the body of lower-priority interrupt handlers. In such programs a programming error can allow interrupt handlers to be interrupted in cyclic fashion to lead to an unbounded stack, causing the system to crash. For a restricted class of interrupt-driven programs, we show that there is a polynomial-time procedure to check stack boundedness, while determining the exact maximum stack size is PSPACE-complete. For a larger class of programs, the two problems are both PSPACE-complete, and for the largest class of programs we consider, the two problems are PSPACE-hard and can be solved in exponential time. acknowledgement: Jens Palsberg, Di Ma, and Tian Zhao were supported by the NSF ITR award 0112628. Thomas A. Henzinger, Krishnendu Chatterjee, and Rupak Majumdar were supported by the AFOSR grant F49620-00-1-0327, the DARPA grants F33615-C-98-3614 and F33615-00-C-1693, the MARCO grant 98-DT-660, and the NSF grants CCR-0208875 and CCR-0085949. alternative_title: - LNCS author: - first_name: Krishnendu full_name: Krishnendu Chatterjee id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Di full_name: Ma, Di last_name: Ma - first_name: Ritankar full_name: Majumdar, Ritankar S last_name: Majumdar - first_name: Tian full_name: Zhao, Tian last_name: Zhao - first_name: Thomas A full_name: Thomas Henzinger id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Jens full_name: Palsberg, Jens last_name: Palsberg citation: ama: 'Chatterjee K, Ma D, Majumdar R, Zhao T, Henzinger TA, Palsberg J. Stack size analysis for interrupt-driven programs. In: Vol 2694. Springer; 2003:109-126. doi:10.1007/3-540-44898-5_7' apa: 'Chatterjee, K., Ma, D., Majumdar, R., Zhao, T., Henzinger, T. A., & Palsberg, J. (2003). Stack size analysis for interrupt-driven programs (Vol. 2694, pp. 109–126). Presented at the SAS: Static Analysis Symposium, Springer. https://doi.org/10.1007/3-540-44898-5_7' chicago: Chatterjee, Krishnendu, Di Ma, Ritankar Majumdar, Tian Zhao, Thomas A Henzinger, and Jens Palsberg. “Stack Size Analysis for Interrupt-Driven Programs,” 2694:109–26. Springer, 2003. https://doi.org/10.1007/3-540-44898-5_7. ieee: 'K. Chatterjee, D. Ma, R. Majumdar, T. Zhao, T. A. Henzinger, and J. Palsberg, “Stack size analysis for interrupt-driven programs,” presented at the SAS: Static Analysis Symposium, 2003, vol. 2694, pp. 109–126.' ista: 'Chatterjee K, Ma D, Majumdar R, Zhao T, Henzinger TA, Palsberg J. 2003. Stack size analysis for interrupt-driven programs. SAS: Static Analysis Symposium, LNCS, vol. 2694, 109–126.' mla: Chatterjee, Krishnendu, et al. Stack Size Analysis for Interrupt-Driven Programs. Vol. 2694, Springer, 2003, pp. 109–26, doi:10.1007/3-540-44898-5_7. short: K. Chatterjee, D. Ma, R. Majumdar, T. Zhao, T.A. Henzinger, J. Palsberg, in:, Springer, 2003, pp. 109–126. conference: name: 'SAS: Static Analysis Symposium' date_created: 2018-12-11T12:05:46Z date_published: 2003-05-28T00:00:00Z date_updated: 2021-01-12T07:53:02Z day: '28' doi: 10.1007/3-540-44898-5_7 extern: 1 intvolume: ' 2694' month: '05' page: 109 - 126 publication_status: published publisher: Springer publist_id: '2260' quality_controlled: 0 status: public title: Stack size analysis for interrupt-driven programs type: conference volume: 2694 year: '2003' ... --- _id: '3993' abstract: - lang: eng text: We present algorithms for constructing a hierarchy of increasingly coarse Morse-Smale complexes that decompose a piecewise linear 2-manifold. While these complexes are defined only in the smooth category, we extend the construction to the piecewise linearcategory by ensuring structural integrity and simulating differentiability. We then simplify Morse-Smale complexes by canceling pairs of critical points in order of increasing persistence. acknowledgement: Partially supported by ARO under Grant DAAG55-98-1-0177, NSF under Grants CCR-97-12088, EIA-9972879 and CCR-00-86013. author: - first_name: Herbert full_name: Herbert Edelsbrunner id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: John full_name: Harer, John last_name: Harer - first_name: Afra full_name: Zomorodian, Afra last_name: Zomorodian citation: ama: Edelsbrunner H, Harer J, Zomorodian A. Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. Discrete & Computational Geometry. 2003;30(1):87-107. doi:10.1007/s00454-003-2926-5 apa: Edelsbrunner, H., Harer, J., & Zomorodian, A. (2003). Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-003-2926-5 chicago: Edelsbrunner, Herbert, John Harer, and Afra Zomorodian. “Hierarchical Morse-Smale Complexes for Piecewise Linear 2-Manifolds.” Discrete & Computational Geometry. Springer, 2003. https://doi.org/10.1007/s00454-003-2926-5. ieee: H. Edelsbrunner, J. Harer, and A. Zomorodian, “Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds,” Discrete & Computational Geometry, vol. 30, no. 1. Springer, pp. 87–107, 2003. ista: Edelsbrunner H, Harer J, Zomorodian A. 2003. Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds. Discrete & Computational Geometry. 30(1), 87–107. mla: Edelsbrunner, Herbert, et al. “Hierarchical Morse-Smale Complexes for Piecewise Linear 2-Manifolds.” Discrete & Computational Geometry, vol. 30, no. 1, Springer, 2003, pp. 87–107, doi:10.1007/s00454-003-2926-5. short: H. Edelsbrunner, J. Harer, A. Zomorodian, Discrete & Computational Geometry 30 (2003) 87–107. date_created: 2018-12-11T12:06:19Z date_published: 2003-07-01T00:00:00Z date_updated: 2021-01-12T07:53:43Z day: '01' doi: 10.1007/s00454-003-2926-5 extern: 1 intvolume: ' 30' issue: '1' month: '07' page: 87 - 107 publication: Discrete & Computational Geometry publication_status: published publisher: Springer publist_id: '2134' quality_controlled: 0 status: public title: Hierarchical Morse-Smale complexes for piecewise linear 2-manifolds type: journal_article volume: 30 year: '2003' ... --- _id: '3994' abstract: - lang: eng text: The body defined by a finite collection of disks is a subset of the plane bounded by a tangent continuous curve, which we call the skin. We give analytic formulas for the area, the perimeter, the area derivative, and the perimeter derivative of the body. Given the filtrations of the Delaunay triangulation and the Voronoi diagram of the disks, all formulas can be evaluated in time proportional to the number of disks. acknowledgement: NSF under grant DMS-98-73945, ARO under grant DAAG55-98-1-0177 and by NSF under grants CCR- 97-12088, EIA-9972879, and CCR-00-86013. author: - first_name: Ho full_name: Cheng, Ho-Lun last_name: Cheng - first_name: Herbert full_name: Herbert Edelsbrunner id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: 'Cheng H, Edelsbrunner H. Area, perimeter and derivatives of a skin curve. Computational Geometry: Theory and Applications. 2003;26(2):173-192. doi:10.1016/S0925-7721(02)00124-4' apa: 'Cheng, H., & Edelsbrunner, H. (2003). Area, perimeter and derivatives of a skin curve. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(02)00124-4' chicago: 'Cheng, Ho, and Herbert Edelsbrunner. “Area, Perimeter and Derivatives of a Skin Curve.” Computational Geometry: Theory and Applications. Elsevier, 2003. https://doi.org/10.1016/S0925-7721(02)00124-4.' ieee: 'H. Cheng and H. Edelsbrunner, “Area, perimeter and derivatives of a skin curve,” Computational Geometry: Theory and Applications, vol. 26, no. 2. Elsevier, pp. 173–192, 2003.' ista: 'Cheng H, Edelsbrunner H. 2003. Area, perimeter and derivatives of a skin curve. Computational Geometry: Theory and Applications. 26(2), 173–192.' mla: 'Cheng, Ho, and Herbert Edelsbrunner. “Area, Perimeter and Derivatives of a Skin Curve.” Computational Geometry: Theory and Applications, vol. 26, no. 2, Elsevier, 2003, pp. 173–92, doi:10.1016/S0925-7721(02)00124-4.' short: 'H. Cheng, H. Edelsbrunner, Computational Geometry: Theory and Applications 26 (2003) 173–192.' date_created: 2018-12-11T12:06:20Z date_published: 2003-10-01T00:00:00Z date_updated: 2021-01-12T07:53:43Z day: '01' doi: 10.1016/S0925-7721(02)00124-4 extern: 1 intvolume: ' 26' issue: '2' month: '10' page: 173 - 192 publication: 'Computational Geometry: Theory and Applications' publication_status: published publisher: Elsevier publist_id: '2135' quality_controlled: 0 status: public title: Area, perimeter and derivatives of a skin curve type: journal_article volume: 26 year: '2003' ... --- _id: '3139' abstract: - lang: eng text: Significant advances have been made during the past few years in our understanding of how the spinal monosynaptic reflex develops. Transcription factors in the Neurogenin, Runt, ETS, and LIM families control sequential steps of the specification of various subtypes of dorsal root ganglia sensory neurons. The initiation of muscle spindle differentiation requires neuregulin 1, derived from Ia afferent sensory neurons, and signaling through ErbB receptors in intrafusal muscle fibers. Several retrograde signals from the periphery are important for the establishment of late connectivity in the reflex circuit. Finally, neurotrophin 3 released from muscle spindles regulates the strength of sensory-motor connections within the spinal cord postnatally. author: - first_name: Hsiao full_name: Chen, Hsiao Huei last_name: Chen - first_name: Simon full_name: Simon Hippenmeyer id: 37B36620-F248-11E8-B48F-1D18A9856A87 last_name: Hippenmeyer orcid: 0000-0003-2279-1061 - first_name: Silvia full_name: Arber, Silvia last_name: Arber - first_name: Eric full_name: Frank, Eric last_name: Frank citation: ama: Chen H, Hippenmeyer S, Arber S, Frank E. Development of the monosynaptic stretch reflex circuit. Current Opinion in Neurobiology. 2003;13(1):96-102. doi:10.1016/S0959-4388(03)00006-0 apa: Chen, H., Hippenmeyer, S., Arber, S., & Frank, E. (2003). Development of the monosynaptic stretch reflex circuit. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/S0959-4388(03)00006-0 chicago: Chen, Hsiao, Simon Hippenmeyer, Silvia Arber, and Eric Frank. “Development of the Monosynaptic Stretch Reflex Circuit.” Current Opinion in Neurobiology. Elsevier, 2003. https://doi.org/10.1016/S0959-4388(03)00006-0. ieee: H. Chen, S. Hippenmeyer, S. Arber, and E. Frank, “Development of the monosynaptic stretch reflex circuit,” Current Opinion in Neurobiology, vol. 13, no. 1. Elsevier, pp. 96–102, 2003. ista: Chen H, Hippenmeyer S, Arber S, Frank E. 2003. Development of the monosynaptic stretch reflex circuit. Current Opinion in Neurobiology. 13(1), 96–102. mla: Chen, Hsiao, et al. “Development of the Monosynaptic Stretch Reflex Circuit.” Current Opinion in Neurobiology, vol. 13, no. 1, Elsevier, 2003, pp. 96–102, doi:10.1016/S0959-4388(03)00006-0. short: H. Chen, S. Hippenmeyer, S. Arber, E. Frank, Current Opinion in Neurobiology 13 (2003) 96–102. date_created: 2018-12-11T12:01:37Z date_published: 2003-02-01T00:00:00Z date_updated: 2019-04-26T07:22:24Z day: '01' doi: 10.1016/S0959-4388(03)00006-0 extern: 1 intvolume: ' 13' issue: '1' month: '02' page: 96 - 102 publication: Current Opinion in Neurobiology publication_status: published publisher: Elsevier publist_id: '3557' quality_controlled: 0 status: public title: Development of the monosynaptic stretch reflex circuit type: review volume: 13 year: '2003' ... --- _id: '3171' abstract: - lang: eng text: 'Reconstructing a 3-D scene from more than one camera is a classical problem in computer vision. One of the major sources of difficulty is the fact that not all scene elements are visible from all cameras. In the last few years, two promising approaches have been developed 11,12 that formulate the scene reconstruction problem in terms of energy minimization, and minimize the energy using graph cuts. These energy minimization approaches treat the input images symmetrically, handle visibility constraints correctly, and allow spatial smoothness to be enforced. However, these algorithm propose different problem formulations, and handle a limited class of smoothness terms. One algorithm 11 uses a problem formulation that is restricted to two-camera stereo, and imposes smoothness between a pair of cameras. The other algorithm 12 can handle an arbitrary number of cameras, but imposes smoothness only with respect to a single camera. In this paper we give a more general energy minimization formulation for the problem, which allows a larger class of spatial smoothness constraints. We show that our formulation includes both of the previous approaches as special cases, as well as permitting new energy functions. Experimental results on real data with ground truth are also included. ' alternative_title: - LNCS author: - first_name: Vladimir full_name: Vladimir Kolmogorov id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87 last_name: Kolmogorov - first_name: Ramin full_name: Zabih, Ramin last_name: Zabih - first_name: Steven full_name: Gortler, Steven last_name: Gortler citation: ama: 'Kolmogorov V, Zabih R, Gortler S. Generalized multi camera scene reconstruction using graph cuts. In: Vol 2683. Springer; 2003:501-516. doi:10.1007/978-3-540-45063-4_32' apa: 'Kolmogorov, V., Zabih, R., & Gortler, S. (2003). Generalized multi camera scene reconstruction using graph cuts (Vol. 2683, pp. 501–516). Presented at the EMMCVPR: Energy Minimization Methods in Computer Vision and Pattern Recognition, Springer. https://doi.org/10.1007/978-3-540-45063-4_32' chicago: Kolmogorov, Vladimir, Ramin Zabih, and Steven Gortler. “Generalized Multi Camera Scene Reconstruction Using Graph Cuts,” 2683:501–16. Springer, 2003. https://doi.org/10.1007/978-3-540-45063-4_32. ieee: 'V. Kolmogorov, R. Zabih, and S. Gortler, “Generalized multi camera scene reconstruction using graph cuts,” presented at the EMMCVPR: Energy Minimization Methods in Computer Vision and Pattern Recognition, 2003, vol. 2683, pp. 501–516.' ista: 'Kolmogorov V, Zabih R, Gortler S. 2003. Generalized multi camera scene reconstruction using graph cuts. EMMCVPR: Energy Minimization Methods in Computer Vision and Pattern Recognition, LNCS, vol. 2683, 501–516.' mla: Kolmogorov, Vladimir, et al. Generalized Multi Camera Scene Reconstruction Using Graph Cuts. Vol. 2683, Springer, 2003, pp. 501–16, doi:10.1007/978-3-540-45063-4_32. short: V. Kolmogorov, R. Zabih, S. Gortler, in:, Springer, 2003, pp. 501–516. conference: name: 'EMMCVPR: Energy Minimization Methods in Computer Vision and Pattern Recognition' date_created: 2018-12-11T12:01:48Z date_published: 2003-06-26T00:00:00Z date_updated: 2021-01-12T07:41:34Z day: '26' doi: 10.1007/978-3-540-45063-4_32 extern: 1 intvolume: ' 2683' month: '06' page: 501 - 516 publication_status: published publisher: Springer publist_id: '3512' quality_controlled: 0 status: public title: Generalized multi camera scene reconstruction using graph cuts type: conference volume: 2683 year: '2003' ... --- _id: '3174' abstract: - lang: eng text: We address visual correspondence problems without assuming that scene points have similar intensities in different views. This situation is common, usually due to non-lambertian scenes or to differences between cameras. We use maximization of mutual information, a powerful technique for registering images that requires no a priori model of the relationship between scene intensities in different views. However, it has proven difficult to use mutual information to compute dense visual correspondence. Comparing fixed-size windows via mutual information suffers from the well-known problems of fixed windows, namely poor performance at discontinuities and in low-texture regions. In this paper, we show how to compute visual correspondence using mutual information without suffering from these problems. Using 'a simple approximation, mutual information can be incorporated into the standard energy minimization framework used in early vision. The energy can then be efficiently minimized using graph cuts, which preserve discontinuities and handle low-texture regions. The resulting algorithm combines the accurate disparity maps that come from graph cuts with the tolerance for intensity changes that comes from mutual information. author: - first_name: Junhwan full_name: Kim, Junhwan last_name: Kim - first_name: Vladimir full_name: Vladimir Kolmogorov id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87 last_name: Kolmogorov - first_name: Ramin full_name: Zabih, Ramin last_name: Zabih citation: ama: 'Kim J, Kolmogorov V, Zabih R. Visual correspondence using energy minimization and mutual information. In: Vol 2. IEEE; 2003:1033-1040. doi:10.1109/ICCV.2003.1238463' apa: 'Kim, J., Kolmogorov, V., & Zabih, R. (2003). Visual correspondence using energy minimization and mutual information (Vol. 2, pp. 1033–1040). Presented at the ICCV: International Conference on Computer Vision, IEEE. https://doi.org/10.1109/ICCV.2003.1238463' chicago: Kim, Junhwan, Vladimir Kolmogorov, and Ramin Zabih. “Visual Correspondence Using Energy Minimization and Mutual Information,” 2:1033–40. IEEE, 2003. https://doi.org/10.1109/ICCV.2003.1238463. ieee: 'J. Kim, V. Kolmogorov, and R. Zabih, “Visual correspondence using energy minimization and mutual information,” presented at the ICCV: International Conference on Computer Vision, 2003, vol. 2, pp. 1033–1040.' ista: 'Kim J, Kolmogorov V, Zabih R. 2003. Visual correspondence using energy minimization and mutual information. ICCV: International Conference on Computer Vision vol. 2, 1033–1040.' mla: Kim, Junhwan, et al. Visual Correspondence Using Energy Minimization and Mutual Information. Vol. 2, IEEE, 2003, pp. 1033–40, doi:10.1109/ICCV.2003.1238463. short: J. Kim, V. Kolmogorov, R. Zabih, in:, IEEE, 2003, pp. 1033–1040. conference: name: 'ICCV: International Conference on Computer Vision' date_created: 2018-12-11T12:01:49Z date_published: 2003-09-30T00:00:00Z date_updated: 2021-01-12T07:41:35Z day: '30' doi: 10.1109/ICCV.2003.1238463 extern: 1 intvolume: ' 2' month: '09' page: 1033 - 1040 publication_status: published publisher: IEEE publist_id: '3510' quality_controlled: 0 status: public title: Visual correspondence using energy minimization and mutual information type: conference volume: 2 year: '2003' ... --- _id: '3170' abstract: - lang: eng text: Geodesic active contours and graph cuts are two standard image segmentation techniques. We introduce a new segmentation method combining some of their benefits. Our main intuition is that any cut on a graph embedded in some continuous space can be interpreted as a contour (in 2D) or a surface (in 3D). We show how to build a grid graph and set its edge weights so that the cost of cuts is arbitrarily close to the length (area) of the corresponding contours (surfaces) for any anisotropic Riemannian metric. There are two interesting consequences of this technical result. First, graph cut algorithms can be used to find globally minimum geodesic contours (minimal surfaces in 3D) under arbitrary Riemannian metric for a given set of boundary conditions. Second, we show how to minimize metrication artifacts in existing graph-cut based methods in vision. Theoretically speaking, our work provides an interesting link between several branches of mathematics -differential geometry, integral geometry, and combinatorial optimization. The main technical problem is solved using Cauchy-Crofton formula from integral geometry. author: - first_name: Yuri full_name: Boykov, Yuri last_name: Boykov - first_name: Vladimir full_name: Vladimir Kolmogorov id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87 last_name: Kolmogorov citation: ama: 'Boykov Y, Kolmogorov V. Computing geodesics and minimal surfaces via graph cuts. In: Vol 1. IEEE; 2003:26-33. doi:10.1109/ICCV.2003.1238310' apa: 'Boykov, Y., & Kolmogorov, V. (2003). Computing geodesics and minimal surfaces via graph cuts (Vol. 1, pp. 26–33). Presented at the ICCV: International Conference on Computer Vision, IEEE. https://doi.org/10.1109/ICCV.2003.1238310' chicago: Boykov, Yuri, and Vladimir Kolmogorov. “Computing Geodesics and Minimal Surfaces via Graph Cuts,” 1:26–33. IEEE, 2003. https://doi.org/10.1109/ICCV.2003.1238310. ieee: 'Y. Boykov and V. Kolmogorov, “Computing geodesics and minimal surfaces via graph cuts,” presented at the ICCV: International Conference on Computer Vision, 2003, vol. 1, pp. 26–33.' ista: 'Boykov Y, Kolmogorov V. 2003. Computing geodesics and minimal surfaces via graph cuts. ICCV: International Conference on Computer Vision vol. 1, 26–33.' mla: Boykov, Yuri, and Vladimir Kolmogorov. Computing Geodesics and Minimal Surfaces via Graph Cuts. Vol. 1, IEEE, 2003, pp. 26–33, doi:10.1109/ICCV.2003.1238310. short: Y. Boykov, V. Kolmogorov, in:, IEEE, 2003, pp. 26–33. conference: name: 'ICCV: International Conference on Computer Vision' date_created: 2018-12-11T12:01:48Z date_published: 2003-09-30T00:00:00Z date_updated: 2021-01-12T07:41:33Z day: '30' doi: 10.1109/ICCV.2003.1238310 extern: 1 intvolume: ' 1' month: '09' page: 26 - 33 publication_status: published publisher: IEEE publist_id: '3511' quality_controlled: 0 status: public title: Computing geodesics and minimal surfaces via graph cuts type: conference volume: 1 year: '2003' ... --- _id: '3526' abstract: - lang: eng text: Neurons can produce action potentials with high temporal precision(1). A fundamental issue is whether, and how, this capability is used in information processing. According to the `cell assembly' hypothesis, transient synchrony of anatomically distributed groups of neurons underlies processing of both external sensory input and internal cognitive mechanisms(2-4). Accordingly, neuron populations should be arranged into groups whose synchrony exceeds that predicted by common modulation by sensory input. Here we find that the spike times of hippocampal pyramidal cells can be predicted more accurately by using the spike times of simultaneously recorded neurons in addition to the animals location in space. This improvement remained when the spatial prediction was refined with a spatially dependent theta phase modulation(5-8). The time window in which spike times are best predicted from simultaneous peer activity is 10-30 ms, suggesting that cell assemblies are synchronized at this timescale. Because this temporal window matches the membrane time constant of pyramidal neurons(9), the period of the hippocampal gamma oscillation(10) and the time window for synaptic plasticity(11), we propose that cooperative activity at this timescale is optimal for information transmission and storage in cortical circuits. author: - first_name: Kenneth full_name: Harris, Kenneth D last_name: Harris - first_name: Jozsef L full_name: Jozsef Csicsvari id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: George full_name: Dragoi, George last_name: Dragoi - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. Organization of cell assemblies in the hippocampus. Nature. 2003;424(6948):552-556. doi:0.1038/nature01834 apa: Harris, K., Csicsvari, J. L., Hirase, H., Dragoi, G., & Buzsáki, G. (2003). Organization of cell assemblies in the hippocampus. Nature. Nature Publishing Group. https://doi.org/0.1038/nature01834 chicago: Harris, Kenneth, Jozsef L Csicsvari, Hajima Hirase, George Dragoi, and György Buzsáki. “Organization of Cell Assemblies in the Hippocampus.” Nature. Nature Publishing Group, 2003. https://doi.org/0.1038/nature01834. ieee: K. Harris, J. L. Csicsvari, H. Hirase, G. Dragoi, and G. Buzsáki, “Organization of cell assemblies in the hippocampus,” Nature, vol. 424, no. 6948. Nature Publishing Group, pp. 552–556, 2003. ista: Harris K, Csicsvari JL, Hirase H, Dragoi G, Buzsáki G. 2003. Organization of cell assemblies in the hippocampus. Nature. 424(6948), 552–556. mla: Harris, Kenneth, et al. “Organization of Cell Assemblies in the Hippocampus.” Nature, vol. 424, no. 6948, Nature Publishing Group, 2003, pp. 552–56, doi:0.1038/nature01834. short: K. Harris, J.L. Csicsvari, H. Hirase, G. Dragoi, G. Buzsáki, Nature 424 (2003) 552–556. date_created: 2018-12-11T12:03:47Z date_published: 2003-07-31T00:00:00Z date_updated: 2021-01-12T07:44:04Z day: '31' doi: 0.1038/nature01834 extern: 1 intvolume: ' 424' issue: '6948' month: '07' page: 552 - 556 publication: Nature publication_status: published publisher: Nature Publishing Group publist_id: '2859' quality_controlled: 0 status: public title: Organization of cell assemblies in the hippocampus type: journal_article volume: 424 year: '2003' ...