---
_id: '2634'
abstract:
- lang: eng
text: To better understand the role of neurotransmitter receptors in neuronal differentiation
and maturation a detailed knowledge of their identity, location and function in
the plasma membrane of specific neuronal populations during development is required.
Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain
slice cultures we show that virtually all neurons (∼98%) migrating through the
lower intermediate zone (LIZ) on their way from the medial ganglionic eminence
to the cerebral cortex, express GABA BR1. Blockade of GABABRs with a specific
antagonist, CGP52432, resulted in a concentration-dependent accumulation of these
tangentially migrating neurons in the ventricular/subventricular zones (VZ/SVZ)
of the cortex and fewer cells were observed in the cortical plate/marginal zone
(CP/MZ) and LIZ. Moreover, they had significantly shorter leading processes compared
with similar migrating cells in control slices. Electrophysiological recording
in LIZ and CP cells revealed no direct effect of either CGP52432 or the GABABR
agonist, baclofen, on resting membrane properties suggesting that the effect of
CGP52432 on migration might be mediated through a metabotropic action or the regulation
of release of factors controlling migration. These results suggest that GABABRs
have an important modulatory role in the migration of cortical interneurons.
author:
- first_name: Guillermina
full_name: López-Bendito, Guillermina
last_name: López Bendito
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Paul
full_name: Ganter, Paul
last_name: Ganter
- first_name: Ole
full_name: Paulsen, Ole
last_name: Paulsen
- first_name: Zoltán
full_name: Molnár, Zoltán
last_name: Molnár
citation:
ama: López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. Blockade
of GABAB receptors alters the tangential migration of cortical neurons. Cerebral
Cortex. 2003;13(9):932-942. doi:10.1093/cercor/13.9.932
apa: López Bendito, G., Luján, R., Shigemoto, R., Ganter, P., Paulsen, O., &
Molnár, Z. (2003). Blockade of GABAB receptors alters the tangential migration
of cortical neurons. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/13.9.932
chicago: López Bendito, Guillermina, Rafael Luján, Ryuichi Shigemoto, Paul Ganter,
Ole Paulsen, and Zoltán Molnár. “Blockade of GABAB Receptors Alters the Tangential
Migration of Cortical Neurons.” Cerebral Cortex. Oxford University Press,
2003. https://doi.org/10.1093/cercor/13.9.932.
ieee: G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, and Z. Molnár,
“Blockade of GABAB receptors alters the tangential migration of cortical neurons,”
Cerebral Cortex, vol. 13, no. 9. Oxford University Press, pp. 932–942,
2003.
ista: López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. 2003.
Blockade of GABAB receptors alters the tangential migration of cortical neurons.
Cerebral Cortex. 13(9), 932–942.
mla: López Bendito, Guillermina, et al. “Blockade of GABAB Receptors Alters the
Tangential Migration of Cortical Neurons.” Cerebral Cortex, vol. 13, no.
9, Oxford University Press, 2003, pp. 932–42, doi:10.1093/cercor/13.9.932.
short: G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, Z. Molnár,
Cerebral Cortex 13 (2003) 932–942.
date_created: 2018-12-11T11:58:47Z
date_published: 2003-09-01T00:00:00Z
date_updated: 2021-01-12T06:58:43Z
day: '01'
doi: 10.1093/cercor/13.9.932
extern: 1
intvolume: ' 13'
issue: '9'
month: '09'
page: 932 - 942
publication: Cerebral Cortex
publication_status: published
publisher: Oxford University Press
publist_id: '4264'
quality_controlled: 0
status: public
title: Blockade of GABAB receptors alters the tangential migration of cortical neurons
type: journal_article
volume: 13
year: '2003'
...
---
_id: '2630'
abstract:
- lang: eng
text: Taste-metabotropic glutamate receptor 4 (taste-mGluR4) and the heteromers
of T1R1 and T1R3 are candidate receptors involved in the sense of umami (monosodium
glutamate) taste. Although the expression of group III mGluRs (taste-mGluR4) has
been demonstrated in taste tissues, no mention has been made of the expression
of group I mGluRs (mGluR1 and mGluR5) in taste tissues. We examined the expression
of mGluR1 and mGluR5 in rat gustatory tissues by using reverse transcription-polymerase
chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoelectron
microscopy. RT-PCR assay showed that mGluR1α and mGluR1β mRNAs were expressed
in circumvallate papillae, but mGluR5 mRNA was not expressed. The positive signals
of mGluR1 mRNA were detected only in circumvallate taste buds by in situ hybridization
analysis. In cryosections of fungiform, foliate and circumvallate papillae, the
antibody against mGluRla gave intense labeling on the taste hairs in all taste
pores examined. In the developing taste buds, the positive signals of mGluR1α
in taste hairs gradually increased with the increase in number of taste bud cells.
These results show that, in addition to taste-mGluR4 and the heteromer of T1R1
and T1R3, mGluR1α may function as a receptor for glutamate (umami) taste sensation.
author:
- first_name: Takashi
full_name: Toyono, Takashi
last_name: Toyono
- first_name: Yuji
full_name: Seta, Yuji
last_name: Seta
- first_name: Shinji
full_name: Kataoka, Shinji
last_name: Kataoka
- first_name: Shintaro
full_name: Kawano, Shintaro
last_name: Kawano
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kuniaki
full_name: Toyoshima, Kuniaki
last_name: Toyoshima
citation:
ama: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression
of metabotropic glutamate receptor group I in rat gustatory papillae. Cell
and Tissue Research. 2003;313(1):29-35. doi:10.1007/s00441-003-0740-2
apa: Toyono, T., Seta, Y., Kataoka, S., Kawano, S., Shigemoto, R., & Toyoshima,
K. (2003). Expression of metabotropic glutamate receptor group I in rat gustatory
papillae. Cell and Tissue Research. Springer. https://doi.org/10.1007/s00441-003-0740-2
chicago: Toyono, Takashi, Yuji Seta, Shinji Kataoka, Shintaro Kawano, Ryuichi Shigemoto,
and Kuniaki Toyoshima. “Expression of Metabotropic Glutamate Receptor Group I
in Rat Gustatory Papillae.” Cell and Tissue Research. Springer, 2003. https://doi.org/10.1007/s00441-003-0740-2.
ieee: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, and K. Toyoshima,
“Expression of metabotropic glutamate receptor group I in rat gustatory papillae,”
Cell and Tissue Research, vol. 313, no. 1. Springer, pp. 29–35, 2003.
ista: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. 2003. Expression
of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and
Tissue Research. 313(1), 29–35.
mla: Toyono, Takashi, et al. “Expression of Metabotropic Glutamate Receptor Group
I in Rat Gustatory Papillae.” Cell and Tissue Research, vol. 313, no. 1,
Springer, 2003, pp. 29–35, doi:10.1007/s00441-003-0740-2.
short: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, K. Toyoshima, Cell
and Tissue Research 313 (2003) 29–35.
date_created: 2018-12-11T11:58:46Z
date_published: 2003-07-01T00:00:00Z
date_updated: 2021-01-12T06:58:41Z
day: '01'
doi: 10.1007/s00441-003-0740-2
extern: 1
intvolume: ' 313'
issue: '1'
month: '07'
page: 29 - 35
publication: Cell and Tissue Research
publication_status: published
publisher: Springer
publist_id: '4267'
quality_controlled: 0
status: public
title: Expression of metabotropic glutamate receptor group I in rat gustatory papillae
type: journal_article
volume: 313
year: '2003'
...
---
_id: '2637'
abstract:
- lang: eng
text: While the cholinergic depletion in Alzheimer's disease (AD) has been known
for some time, a definitive involvement of other neurotransmitter systems has
been somewhat more elusive. Our study demonstrates a clear involvement of both
glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic
mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent
quantification has revealed a statistically significant increased density of glutamatergic
and GABAergic presynaptic boutons in both the plaque free and plaque adjacent
cortical neuropile areas of transgenic mice as compared to non-transgenic controls.
Furthermore, amyloid plaque size was shown to have a statistically significant
effect on the relative area occupied by dystrophic glutamatergic neurites in the
peri-plaque neuropile. These findings support our hypothesis that the amyloid
pathology progresses in a time and neurotransmitter specific manner, first in
the cholinergic system which appears to be most vulnerable, followed by the glutamatergic
presynaptic boutons and finally the somewhat more resilient GABAergic terminals.
author:
- first_name: Karen
full_name: Bell, Karen F
last_name: Bell
- first_name: G J
full_name: De Kort, G J
last_name: De Kort
- first_name: S
full_name: Steggerda, S
last_name: Steggerda
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro-da-Silva, Alfredo
last_name: Ribeiro Da Silva
- first_name: Augusto
full_name: Cuello, Augusto C
last_name: Cuello
citation:
ama: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A.
Structural involvement of the glutamatergic presynaptic boutons in a transgenic
mouse model expressing early onset amyloid pathology. Neuroscience Letters.
2003;353(2):143-147. doi:10.1016/j.neulet.2003.09.027
apa: Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A.,
& Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic
boutons in a transgenic mouse model expressing early onset amyloid pathology.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/j.neulet.2003.09.027
chicago: Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro
Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic
Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.”
Neuroscience Letters. Elsevier, 2003. https://doi.org/10.1016/j.neulet.2003.09.027.
ieee: K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and
A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in
a transgenic mouse model expressing early onset amyloid pathology,” Neuroscience
Letters, vol. 353, no. 2. Elsevier, pp. 143–147, 2003.
ista: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A.
2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic
mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2),
143–147.
mla: Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic
Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.”
Neuroscience Letters, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:10.1016/j.neulet.2003.09.027.
short: K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A.
Cuello, Neuroscience Letters 353 (2003) 143–147.
date_created: 2018-12-11T11:58:48Z
date_published: 2003-12-19T00:00:00Z
date_updated: 2021-01-12T06:58:44Z
day: '19'
doi: 10.1016/j.neulet.2003.09.027
extern: 1
intvolume: ' 353'
issue: '2'
month: '12'
page: 143 - 147
publication: Neuroscience Letters
publication_status: published
publisher: Elsevier
publist_id: '4262'
quality_controlled: 0
status: public
title: Structural involvement of the glutamatergic presynaptic boutons in a transgenic
mouse model expressing early onset amyloid pathology
type: journal_article
volume: 353
year: '2003'
...
---
_id: '2784'
abstract:
- lang: eng
text: We report the results of an experimental study of magnetohydrodynamic damping
of sidewall convection in a rectangular enclosure filled with gallium. In particular
we investigate the suppression of convection when a steady magnetic field is applied
separately in each of the three principal directions of the flow. The strongest
damping of the steady flow is found for a vertical magnetic field, which is in
agreement with theory. However, we observe that the application of a field transverse
to the flow provides greater damping than a longitudinal one, which seems to contradict
available theory. We provide a possible resolution of this apparent dichotomy
in terms of the length scale of the experiment.
author:
- first_name: Björn
full_name: Björn Hof
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Anne
full_name: Juel, Anne
last_name: Juel
- first_name: Tom
full_name: Mullin, Tom P
last_name: Mullin
citation:
ama: Hof B, Juel A, Mullin T. Magnetohydrodynamic damping of convective flows in
molten gallium. Journal of Fluid Mechanics. 2003;482:163-179. doi:10.1017/S0022112003004014
apa: Hof, B., Juel, A., & Mullin, T. (2003). Magnetohydrodynamic damping of
convective flows in molten gallium. Journal of Fluid Mechanics. Cambridge
University Press. https://doi.org/10.1017/S0022112003004014
chicago: Hof, Björn, Anne Juel, and Tom Mullin. “Magnetohydrodynamic Damping of
Convective Flows in Molten Gallium.” Journal of Fluid Mechanics. Cambridge
University Press, 2003. https://doi.org/10.1017/S0022112003004014.
ieee: B. Hof, A. Juel, and T. Mullin, “Magnetohydrodynamic damping of convective
flows in molten gallium,” Journal of Fluid Mechanics, vol. 482. Cambridge
University Press, pp. 163–179, 2003.
ista: Hof B, Juel A, Mullin T. 2003. Magnetohydrodynamic damping of convective flows
in molten gallium. Journal of Fluid Mechanics. 482, 163–179.
mla: Hof, Björn, et al. “Magnetohydrodynamic Damping of Convective Flows in Molten
Gallium.” Journal of Fluid Mechanics, vol. 482, Cambridge University Press,
2003, pp. 163–79, doi:10.1017/S0022112003004014.
short: B. Hof, A. Juel, T. Mullin, Journal of Fluid Mechanics 482 (2003) 163–179.
date_created: 2018-12-11T11:59:35Z
date_published: 2003-05-13T00:00:00Z
date_updated: 2021-01-12T06:59:42Z
day: '13'
doi: 10.1017/S0022112003004014
extern: 1
intvolume: ' 482'
month: '05'
page: 163 - 179
publication: Journal of Fluid Mechanics
publication_status: published
publisher: Cambridge University Press
publist_id: '4105'
quality_controlled: 0
status: public
title: Magnetohydrodynamic damping of convective flows in molten gallium
type: journal_article
volume: 482
year: '2003'
...
---
_id: '2785'
abstract:
- lang: eng
text: Experimental evidence for the scaling of the finite amplitude of perturbation
theory required to promote transition in Poiseuille flow was found. The exponent
is -1 and was uncovered using considerable care in the design and execution of
the experiment. Interestingly, this exponent was also found in experiments on
transition in boundary layers.
author:
- first_name: Björn
full_name: Björn Hof
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Anne
full_name: Juel, Anne
last_name: Juel
- first_name: Tom
full_name: Mullin, Tom P
last_name: Mullin
citation:
ama: Hof B, Juel A, Mullin T. Scaling of the turbulence transition threshold in
a pipe. Physical Review Letters. 2003;91(24):244502/1-244502/4. doi:10.1103/PhysRevLett.91.244502
apa: Hof, B., Juel, A., & Mullin, T. (2003). Scaling of the turbulence transition
threshold in a pipe. Physical Review Letters. American Physical Society.
https://doi.org/10.1103/PhysRevLett.91.244502
chicago: Hof, Björn, Anne Juel, and Tom Mullin. “Scaling of the Turbulence Transition
Threshold in a Pipe.” Physical Review Letters. American Physical Society,
2003. https://doi.org/10.1103/PhysRevLett.91.244502.
ieee: B. Hof, A. Juel, and T. Mullin, “Scaling of the turbulence transition threshold
in a pipe,” Physical Review Letters, vol. 91, no. 24. American Physical
Society, p. 244502/1-244502/4, 2003.
ista: Hof B, Juel A, Mullin T. 2003. Scaling of the turbulence transition threshold
in a pipe. Physical Review Letters. 91(24), 244502/1-244502/4.
mla: Hof, Björn, et al. “Scaling of the Turbulence Transition Threshold in a Pipe.”
Physical Review Letters, vol. 91, no. 24, American Physical Society, 2003,
p. 244502/1-244502/4, doi:10.1103/PhysRevLett.91.244502.
short: B. Hof, A. Juel, T. Mullin, Physical Review Letters 91 (2003) 244502/1-244502/4.
date_created: 2018-12-11T11:59:35Z
date_published: 2003-12-12T00:00:00Z
date_updated: 2021-01-12T06:59:42Z
day: '12'
doi: 10.1103/PhysRevLett.91.244502
extern: 1
intvolume: ' 91'
issue: '24'
month: '12'
page: 244502/1 - 244502/4
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '4104'
quality_controlled: 0
status: public
title: Scaling of the turbulence transition threshold in a pipe
type: journal_article
volume: 91
year: '2003'
...