--- _id: '6157' abstract: - lang: eng text: In many animal species individuals aggregate to live in groups. A range of experimental approaches in different animals, including studies of social feeding in nematodes, maternal behavior in rats and sheep, and pair-bonding in voles, are providing insights into the neural bases for these behaviors. These studies are delineating multiple neural circuits and gene networks in the brain that interact in ways that are as yet poorly understood to coordinate social behavior. author: - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 citation: ama: de Bono M. Molecular approaches to aggregation behavior and social attachment. Journal of Neurobiology. 2003;54(1):78-92. doi:10.1002/neu.10162 apa: de Bono, M. (2003). Molecular approaches to aggregation behavior and social attachment. Journal of Neurobiology. Wiley. https://doi.org/10.1002/neu.10162 chicago: Bono, Mario de. “Molecular Approaches to Aggregation Behavior and Social Attachment.” Journal of Neurobiology. Wiley, 2003. https://doi.org/10.1002/neu.10162. ieee: M. de Bono, “Molecular approaches to aggregation behavior and social attachment,” Journal of Neurobiology, vol. 54, no. 1. Wiley, pp. 78–92, 2003. ista: de Bono M. 2003. Molecular approaches to aggregation behavior and social attachment. Journal of Neurobiology. 54(1), 78–92. mla: de Bono, Mario. “Molecular Approaches to Aggregation Behavior and Social Attachment.” Journal of Neurobiology, vol. 54, no. 1, Wiley, 2003, pp. 78–92, doi:10.1002/neu.10162. short: M. de Bono, Journal of Neurobiology 54 (2003) 78–92. date_created: 2019-03-21T09:52:31Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T08:06:26Z day: '01' doi: 10.1002/neu.10162 extern: '1' external_id: pmid: - '12486699' intvolume: ' 54' issue: '1' language: - iso: eng month: '01' oa_version: None page: 78-92 pmid: 1 publication: Journal of Neurobiology publication_identifier: issn: - 0022-3034 - 1097-4695 publication_status: published publisher: Wiley quality_controlled: '1' status: public title: Molecular approaches to aggregation behavior and social attachment type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 54 year: '2003' ... --- _id: '847' abstract: - lang: eng text: The accumulation of genome-wide information on single nucleotide polymorphisms in humans provides an unprecedented opportunity to detect the evolutionary forces responsible for heterogeneity of the level of genetic variability across loci. Previous studies have shown that history of recombination events has produced long haplotype blocks in the human genome, which contribute to this heterogeneity. Other factors, however, such as natural selection or the heterogeneity of mutation rates across loci, may also lead to heterogeneity of genetic variability. We compared synonymous and non-synonymous variability within human genes with their divergence from murine orthologs. We separately analyzed the non-synonymous variants predicted to damage protein structure or function and the variants predicted to be functionally benign. The predictions were based on comparative sequence analysis and, in some cases, on the analysis of protein structure. A strong correlation between non-synonymous, benign variability and non-synonymous human-mouse divergence suggests that selection played an important role in shaping the pattern of variability in coding regions of human genes. However, the lack of correlation between deleterious variability and evolutionary divergence shows that a substantial proportion of the observed non-synonymous single-nucleotide polymorphisms reduces fitness and never reaches fixation. Evolutionary and medical implications of the impact of selection on human polymorphisms are discussed. acknowledgement: We are grateful to Alexey Kondrashov and Alison Wellman for the careful reading of the manuscript and providing us with their valuable comments. author: - first_name: Shamil full_name: Sunyaev, Shamil R last_name: Sunyaev - first_name: Fyodor full_name: Fyodor Kondrashov id: 44FDEF62-F248-11E8-B48F-1D18A9856A87 last_name: Kondrashov orcid: 0000-0001-8243-4694 - first_name: Peer full_name: Bork, Peer last_name: Bork - first_name: Vasily full_name: Ramensky, Vasily last_name: Ramensky citation: ama: Sunyaev S, Kondrashov F, Bork P, Ramensky V. Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics. 2003;12(24):3325-3330. doi:10.1093/hmg/ddg359 apa: Sunyaev, S., Kondrashov, F., Bork, P., & Ramensky, V. (2003). Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics. Oxford University Press. https://doi.org/10.1093/hmg/ddg359 chicago: Sunyaev, Shamil, Fyodor Kondrashov, Peer Bork, and Vasily Ramensky. “Impact of Selection, Mutation Rate and Genetic Drift on Human Genetic Variation.” Human Molecular Genetics. Oxford University Press, 2003. https://doi.org/10.1093/hmg/ddg359. ieee: S. Sunyaev, F. Kondrashov, P. Bork, and V. Ramensky, “Impact of selection, mutation rate and genetic drift on human genetic variation,” Human Molecular Genetics, vol. 12, no. 24. Oxford University Press, pp. 3325–3330, 2003. ista: Sunyaev S, Kondrashov F, Bork P, Ramensky V. 2003. Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics. 12(24), 3325–3330. mla: Sunyaev, Shamil, et al. “Impact of Selection, Mutation Rate and Genetic Drift on Human Genetic Variation.” Human Molecular Genetics, vol. 12, no. 24, Oxford University Press, 2003, pp. 3325–30, doi:10.1093/hmg/ddg359. short: S. Sunyaev, F. Kondrashov, P. Bork, V. Ramensky, Human Molecular Genetics 12 (2003) 3325–3330. date_created: 2018-12-11T11:48:49Z date_published: 2003-12-15T00:00:00Z date_updated: 2021-01-12T08:19:29Z day: '15' doi: 10.1093/hmg/ddg359 extern: 1 intvolume: ' 12' issue: '24' month: '12' page: 3325 - 3330 publication: Human Molecular Genetics publication_status: published publisher: Oxford University Press publist_id: '6803' quality_controlled: 0 status: public title: Impact of selection, mutation rate and genetic drift on human genetic variation type: journal_article volume: 12 year: '2003' ... --- _id: '876' abstract: - lang: eng text: Alternative splicing is thought to be a major source of functional diversity in animal proteins. We analyzed the evolutionary conservation of proteins encoded by alternatively spliced genes and predicted the ancestral state for 73 cases of alternative splicing (25 insertions and 48 deletions). The amino acid sequences of most of the inserts in proteins produced by alternative splicing are as conserved as the surrounding sequences. Thus, alternative splicing often creates novel isoforms by the insertion of new, functional protein sequences that probably originated from noncoding sequences of introns. acknowledgement: We thank Peer Bork, Mikhail Gelfand, Alexey Kondrashov, David Lipman and Shamil Sunyaev for critical reading of the manuscript and useful suggestions and the Koonin group members for helpful discussions. author: - first_name: Fyodor full_name: Fyodor Kondrashov id: 44FDEF62-F248-11E8-B48F-1D18A9856A87 last_name: Kondrashov orcid: 0000-0001-8243-4694 - first_name: Eugene full_name: Koonin, Eugene V last_name: Koonin citation: ama: 'Kondrashov F, Koonin E. Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics. 2003;19(3):115-119. doi:10.1016/S0168-9525(02)00029-X' apa: 'Kondrashov, F., & Koonin, E. (2003). Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics. Elsevier. https://doi.org/10.1016/S0168-9525(02)00029-X' chicago: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing: Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.” Trends in Genetics. Elsevier, 2003. https://doi.org/10.1016/S0168-9525(02)00029-X.' ieee: 'F. Kondrashov and E. Koonin, “Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences,” Trends in Genetics, vol. 19, no. 3. Elsevier, pp. 115–119, 2003.' ista: 'Kondrashov F, Koonin E. 2003. Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences. Trends in Genetics. 19(3), 115–119.' mla: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing: Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.” Trends in Genetics, vol. 19, no. 3, Elsevier, 2003, pp. 115–19, doi:10.1016/S0168-9525(02)00029-X.' short: F. Kondrashov, E. Koonin, Trends in Genetics 19 (2003) 115–119. date_created: 2018-12-11T11:48:58Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T08:20:58Z day: '01' doi: 10.1016/S0168-9525(02)00029-X extern: 1 intvolume: ' 19' issue: '3' month: '01' page: 115 - 119 publication: Trends in Genetics publication_status: published publisher: Elsevier publist_id: '6776' quality_controlled: 0 status: public title: 'Evolution of alternative splicing: Deletions, insertions and origin of functional parts of proteins from intron sequences' type: journal_article volume: 19 year: '2003' ... --- _id: '9495' abstract: - lang: eng text: RNA interference is a conserved process in which double-stranded RNA is processed into 21–25 nucleotide siRNAs that trigger posttranscriptional gene silencing. In addition, plants display a phenomenon termed RNA-directed DNA methylation (RdDM) in which DNA with sequence identity to silenced RNA is de novo methylated at its cytosine residues. This methylation is not only at canonical CpG sites but also at cytosines in CpNpG and asymmetric sequence contexts. In this report, we study the role of the DRM and CMT3 DNA methyltransferase genes in the initiation and maintenance of RdDM. Neither drm nor cmt3 mutants affected the maintenance of preestablished RNA-directed CpG methylation. However, drm mutants showed a nearly complete loss of asymmetric methylation and a partial loss of CpNpG methylation. The remaining asymmetric and CpNpG methylation was dependent on the activity of CMT3, showing that DRM and CMT3 act redundantly to maintain non-CpG methylation. These DNA methyltransferases appear to act downstream of siRNAs, since drm1 drm2 cmt3 triple mutants show a lack of non-CpG methylation but elevated levels of siRNAs. Finally, we demonstrate that DRM activity is required for the initial establishment of RdDM in all sequence contexts including CpG, CpNpG, and asymmetric sites. article_processing_charge: No article_type: original author: - first_name: Xiaofeng full_name: Cao, Xiaofeng last_name: Cao - first_name: Werner full_name: Aufsatz, Werner last_name: Aufsatz - first_name: Daniel full_name: Zilberman, Daniel id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1 last_name: Zilberman orcid: 0000-0002-0123-8649 - first_name: M.Florian full_name: Mette, M.Florian last_name: Mette - first_name: Michael S. full_name: Huang, Michael S. last_name: Huang - first_name: Marjori full_name: Matzke, Marjori last_name: Matzke - first_name: Steven E. full_name: Jacobsen, Steven E. last_name: Jacobsen citation: ama: Cao X, Aufsatz W, Zilberman D, et al. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Current Biology. 2003;13(24):2212-2217. doi:10.1016/j.cub.2003.11.052 apa: Cao, X., Aufsatz, W., Zilberman, D., Mette, M. F., Huang, M. S., Matzke, M., & Jacobsen, S. E. (2003). Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2003.11.052 chicago: Cao, Xiaofeng, Werner Aufsatz, Daniel Zilberman, M.Florian Mette, Michael S. Huang, Marjori Matzke, and Steven E. Jacobsen. “Role of the DRM and CMT3 Methyltransferases in RNA-Directed DNA Methylation.” Current Biology. Elsevier, 2003. https://doi.org/10.1016/j.cub.2003.11.052. ieee: X. Cao et al., “Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation,” Current Biology, vol. 13, no. 24. Elsevier, pp. 2212–2217, 2003. ista: Cao X, Aufsatz W, Zilberman D, Mette MF, Huang MS, Matzke M, Jacobsen SE. 2003. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Current Biology. 13(24), 2212–2217. mla: Cao, Xiaofeng, et al. “Role of the DRM and CMT3 Methyltransferases in RNA-Directed DNA Methylation.” Current Biology, vol. 13, no. 24, Elsevier, 2003, pp. 2212–17, doi:10.1016/j.cub.2003.11.052. short: X. Cao, W. Aufsatz, D. Zilberman, M.F. Mette, M.S. Huang, M. Matzke, S.E. Jacobsen, Current Biology 13 (2003) 2212–2217. date_created: 2021-06-07T10:43:02Z date_published: 2003-12-16T00:00:00Z date_updated: 2021-12-14T08:41:38Z day: '16' department: - _id: DaZi doi: 10.1016/j.cub.2003.11.052 extern: '1' external_id: pmid: - '14680640' intvolume: ' 13' issue: '24' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1016/j.cub.2003.11.052 month: '12' oa: 1 oa_version: Published Version page: 2212-2217 pmid: 1 publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 13 year: '2003' ... --- _id: '8519' article_processing_charge: No article_type: original author: - first_name: Vadim full_name: Kaloshin, Vadim id: FE553552-CDE8-11E9-B324-C0EBE5697425 last_name: Kaloshin orcid: 0000-0002-6051-2628 citation: ama: Kaloshin V. The existential Hilbert 16-th problem and an estimate for cyclicity of elementary polycycles. Inventiones mathematicae. 2003;151(3):451-512. doi:10.1007/s00222-002-0244-9 apa: Kaloshin, V. (2003). The existential Hilbert 16-th problem and an estimate for cyclicity of elementary polycycles. Inventiones Mathematicae. Springer Nature. https://doi.org/10.1007/s00222-002-0244-9 chicago: Kaloshin, Vadim. “The Existential Hilbert 16-Th Problem and an Estimate for Cyclicity of Elementary Polycycles.” Inventiones Mathematicae. Springer Nature, 2003. https://doi.org/10.1007/s00222-002-0244-9. ieee: V. Kaloshin, “The existential Hilbert 16-th problem and an estimate for cyclicity of elementary polycycles,” Inventiones mathematicae, vol. 151, no. 3. Springer Nature, pp. 451–512, 2003. ista: Kaloshin V. 2003. The existential Hilbert 16-th problem and an estimate for cyclicity of elementary polycycles. Inventiones mathematicae. 151(3), 451–512. mla: Kaloshin, Vadim. “The Existential Hilbert 16-Th Problem and an Estimate for Cyclicity of Elementary Polycycles.” Inventiones Mathematicae, vol. 151, no. 3, Springer Nature, 2003, pp. 451–512, doi:10.1007/s00222-002-0244-9. short: V. Kaloshin, Inventiones Mathematicae 151 (2003) 451–512. date_created: 2020-09-18T10:49:26Z date_published: 2003-03-01T00:00:00Z date_updated: 2021-01-12T08:19:50Z day: '01' doi: 10.1007/s00222-002-0244-9 extern: '1' intvolume: ' 151' issue: '3' keyword: - General Mathematics language: - iso: eng month: '03' oa_version: None page: 451-512 publication: Inventiones mathematicae publication_identifier: issn: - 0020-9910 - 1432-1297 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: The existential Hilbert 16-th problem and an estimate for cyclicity of elementary polycycles type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 151 year: '2003' ... --- _id: '9455' abstract: - lang: eng text: Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation. article_processing_charge: No article_type: original author: - first_name: Daniel full_name: Zilberman, Daniel id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1 last_name: Zilberman orcid: 0000-0002-0123-8649 - first_name: ' Xiaofeng' full_name: Cao, Xiaofeng last_name: Cao - first_name: Steven E. full_name: Jacobsen, Steven E. last_name: Jacobsen citation: ama: Zilberman D, Cao Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. 2003;299(5607):716-719. doi:10.1126/science.1079695 apa: Zilberman, D., Cao, Xiaofeng, & Jacobsen, S. E. (2003). ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1079695 chicago: Zilberman, Daniel, Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” Science. American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1079695. ieee: D. Zilberman, Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation,” Science, vol. 299, no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003. ista: Zilberman D, Cao Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719. mla: Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” Science, vol. 299, no. 5607, American Association for the Advancement of Science, 2003, pp. 716–19, doi:10.1126/science.1079695. short: D. Zilberman, Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719. date_created: 2021-06-04T11:26:26Z date_published: 2003-01-31T00:00:00Z date_updated: 2021-12-14T08:43:30Z day: '31' department: - _id: DaZi doi: 10.1126/science.1079695 extern: '1' external_id: pmid: - '12522258' intvolume: ' 299' issue: '5607' keyword: - Multidisciplinary language: - iso: eng month: '01' oa_version: None page: 716-719 pmid: 1 publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: American Association for the Advancement of Science quality_controlled: '1' scopus_import: '1' status: public title: ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation type: journal_article user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 volume: 299 year: '2003' ... --- _id: '4628' abstract: - lang: eng text: 'Discounting the future means that the value, today, of a unit payoffis 1 if the payoffo ccurs today, a if it occurs tomorrow, a 2 if it occurs the day after tomorrow, and so on, for some real-valued discount factor 0 < a < 1. Discounting (or inflation) is a key paradigm in economics and has been studied in Markov decision processes as well as game theory. We submit that discounting also has a natural place in systems engineering: for nonterminating systems, a potential bug in the far-away future is less troubling than a potential bug today. We therefore develop a systems theory with discounting. Our theory includes several basic elements: discounted versions of system properties that correspond to the ω-regular properties, fixpoint-based algorithms for checking discounted properties, and a quantitative notion of bisimilarity for capturing the difference between two states with respect to discounted properties. We present the theory in a general form that applies to probabilistic systems as well as multicomponent systems (games), but it readily specializes to classical transition systems. We show that discounting, besides its natural practical appeal, has also several mathematical benefits. First, the resulting theory is robust, in that small perturbations of a system can cause only small changes in the properties of the system. Second, the theory is computational, in that the values of discounted properties, as well as the discounted bisimilarity distance between states, can be computed to any desired degree of precision.' acknowledgement: This research was supported in part by the NSF CAREER award CCR-0132780, the DARPA grant F33615-C-98-3614, the NSF grants CCR-9988172, CCR-0234690 and CCR-0225610, and the ONR grant N00014-02-1-0671. alternative_title: - LNCS article_processing_charge: No author: - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar citation: ama: 'De Alfaro L, Henzinger TA, Majumdar R. Discounting the future in systems theory. In: Proceedings of the 30th International Colloquium on Automata, Languages and Programming. Vol 2719. Springer; 2003:1022-1037. doi:10.1007/3-540-45061-0_79' apa: 'De Alfaro, L., Henzinger, T. A., & Majumdar, R. (2003). Discounting the future in systems theory. In Proceedings of the 30th International Colloquium on Automata, Languages and Programming (Vol. 2719, pp. 1022–1037). Eindhoven, The Netherlands: Springer. https://doi.org/10.1007/3-540-45061-0_79' chicago: De Alfaro, Luca, Thomas A Henzinger, and Ritankar Majumdar. “Discounting the Future in Systems Theory.” In Proceedings of the 30th International Colloquium on Automata, Languages and Programming, 2719:1022–37. Springer, 2003. https://doi.org/10.1007/3-540-45061-0_79. ieee: L. De Alfaro, T. A. Henzinger, and R. Majumdar, “Discounting the future in systems theory,” in Proceedings of the 30th International Colloquium on Automata, Languages and Programming, Eindhoven, The Netherlands, 2003, vol. 2719, pp. 1022–1037. ista: 'De Alfaro L, Henzinger TA, Majumdar R. 2003. Discounting the future in systems theory. Proceedings of the 30th International Colloquium on Automata, Languages and Programming. ICALP: Automata, Languages and Programming, LNCS, vol. 2719, 1022–1037.' mla: De Alfaro, Luca, et al. “Discounting the Future in Systems Theory.” Proceedings of the 30th International Colloquium on Automata, Languages and Programming, vol. 2719, Springer, 2003, pp. 1022–37, doi:10.1007/3-540-45061-0_79. short: L. De Alfaro, T.A. Henzinger, R. Majumdar, in:, Proceedings of the 30th International Colloquium on Automata, Languages and Programming, Springer, 2003, pp. 1022–1037. conference: end_date: 2003-07-04 location: Eindhoven, The Netherlands name: 'ICALP: Automata, Languages and Programming' start_date: 2003-06-30 date_created: 2018-12-11T12:09:50Z date_published: 2003-06-25T00:00:00Z date_updated: 2023-07-26T13:07:31Z day: '25' doi: 10.1007/3-540-45061-0_79 extern: '1' intvolume: ' 2719' language: - iso: eng month: '06' oa_version: None page: 1022 - 1037 publication: Proceedings of the 30th International Colloquium on Automata, Languages and Programming publication_identifier: isbn: - '9783540404934' publication_status: published publisher: Springer publist_id: '77' quality_controlled: '1' scopus_import: '1' status: public title: Discounting the future in systems theory type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2719 year: '2003' ... --- _id: '13436' abstract: - lang: eng text: Cross-metathesis reactions of α,β-unsaturated sulfones and sulfoxides in the presence of molybdenum and ruthenium pre-catalysts were tested. A selective metahesis reaction was achieved between functionalized terminal olefins and vinyl sulfones by using the ‘second generation’ ruthenium catalysts 1c–h while the highly active Schrock catalyst 1b was found to be functional group incompatible with vinyl sulfones. The cross-metathesis products were isolated in good yields with an excellent (E)-selectivity. Both the molybdenum and ruthenium-based complexes were, however, incompatible with α,β- and β,γ-unsaturated sulfoxides. article_processing_charge: No article_type: original author: - first_name: Anna full_name: Michrowska, Anna last_name: Michrowska - first_name: Michał full_name: Bieniek, Michał last_name: Bieniek - first_name: Mikhail full_name: Kim, Mikhail last_name: Kim - first_name: Rafal full_name: Klajn, Rafal id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b last_name: Klajn - first_name: Karol full_name: Grela, Karol last_name: Grela citation: ama: Michrowska A, Bieniek M, Kim M, Klajn R, Grela K. Cross-metathesis reaction of vinyl sulfones and sulfoxides. Tetrahedron. 2003;59(25):4525-4531. doi:10.1016/s0040-4020(03)00682-3 apa: Michrowska, A., Bieniek, M., Kim, M., Klajn, R., & Grela, K. (2003). Cross-metathesis reaction of vinyl sulfones and sulfoxides. Tetrahedron. Elsevier. https://doi.org/10.1016/s0040-4020(03)00682-3 chicago: Michrowska, Anna, Michał Bieniek, Mikhail Kim, Rafal Klajn, and Karol Grela. “Cross-Metathesis Reaction of Vinyl Sulfones and Sulfoxides.” Tetrahedron. Elsevier, 2003. https://doi.org/10.1016/s0040-4020(03)00682-3. ieee: A. Michrowska, M. Bieniek, M. Kim, R. Klajn, and K. Grela, “Cross-metathesis reaction of vinyl sulfones and sulfoxides,” Tetrahedron, vol. 59, no. 25. Elsevier, pp. 4525–4531, 2003. ista: Michrowska A, Bieniek M, Kim M, Klajn R, Grela K. 2003. Cross-metathesis reaction of vinyl sulfones and sulfoxides. Tetrahedron. 59(25), 4525–4531. mla: Michrowska, Anna, et al. “Cross-Metathesis Reaction of Vinyl Sulfones and Sulfoxides.” Tetrahedron, vol. 59, no. 25, Elsevier, 2003, pp. 4525–31, doi:10.1016/s0040-4020(03)00682-3. short: A. Michrowska, M. Bieniek, M. Kim, R. Klajn, K. Grela, Tetrahedron 59 (2003) 4525–4531. date_created: 2023-08-01T10:39:34Z date_published: 2003-06-16T00:00:00Z date_updated: 2023-08-08T12:44:17Z day: '16' doi: 10.1016/s0040-4020(03)00682-3 extern: '1' intvolume: ' 59' issue: '25' keyword: - Organic Chemistry - Drug Discovery - Biochemistry language: - iso: eng month: '06' oa_version: None page: 4525-4531 publication: Tetrahedron publication_identifier: eissn: - 1464-5416 issn: - 0040-4020 publication_status: published publisher: Elsevier quality_controlled: '1' scopus_import: '1' status: public title: Cross-metathesis reaction of vinyl sulfones and sulfoxides type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 59 year: '2003' ... --- _id: '4561' abstract: - lang: eng text: 'We present a formalism for specifying component interfaces that expose component requirements on limited resources. The formalism permits an algorithmic check if two or more components, when put together, exceed the available resources. Moreover, the formalism can be used to compute the quantity of resources necessary for satisfying the requirements of a collection of components. The formalism can be instantiated in several ways. For example, several components may draw power from the same source. Then, the formalism supports compatibility checks such as: can two components, when put together, achieve their tasks without ever exceeding the available amount of peak power? or, can they achieve their tasks by using no more than the initially available amount of energy (i.e., power accumulated over time)? The corresponding quantitative questions that our algorithms answer are the following: what is the amount of peak power needed for two components to be put together? what is the corresponding amount of initial energy? To solve these questions, we model interfaces with resource requirements as games with quantitative objectives. The games are played on state spaces where each state is labeled by a number (representing, e.g., power consumption), and a play produces an infinite path of labels. The objective may be, for example, to minimize the largest label that occurs during a play. We illustrate our approach by modeling compatibility questions for the components of robot control software, and of wireless sensor networks.' acknowledgement: This research was supported in part by the DARPA grant F33615-00-C-1693, the MARCO grant 98-DT-660, the ONR grant N00014-02-1-0671, and the NSF grants CCR-0085949, CCR-0132780, CCR-0234690, and CCR-9988172. alternative_title: - LNCS article_processing_charge: No author: - first_name: Arindam full_name: Chakrabarti, Arindam last_name: Chakrabarti - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Mariëlle full_name: Stoelinga, Mariëlle last_name: Stoelinga citation: ama: 'Chakrabarti A, De Alfaro L, Henzinger TA, Stoelinga M. Resource interfaces. In: Third International Conference on Embedded Software. Vol 2855. ACM; 2003:117-133. doi:10.1007/978-3-540-45212-6_9' apa: 'Chakrabarti, A., De Alfaro, L., Henzinger, T. A., & Stoelinga, M. (2003). Resource interfaces. In Third International Conference on Embedded Software (Vol. 2855, pp. 117–133). Philadelphia, PA, USA: ACM. https://doi.org/10.1007/978-3-540-45212-6_9' chicago: Chakrabarti, Arindam, Luca De Alfaro, Thomas A Henzinger, and Mariëlle Stoelinga. “Resource Interfaces.” In Third International Conference on Embedded Software, 2855:117–33. ACM, 2003. https://doi.org/10.1007/978-3-540-45212-6_9. ieee: A. Chakrabarti, L. De Alfaro, T. A. Henzinger, and M. Stoelinga, “Resource interfaces,” in Third International Conference on Embedded Software, Philadelphia, PA, USA, 2003, vol. 2855, pp. 117–133. ista: 'Chakrabarti A, De Alfaro L, Henzinger TA, Stoelinga M. 2003. Resource interfaces. Third International Conference on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2855, 117–133.' mla: Chakrabarti, Arindam, et al. “Resource Interfaces.” Third International Conference on Embedded Software, vol. 2855, ACM, 2003, pp. 117–33, doi:10.1007/978-3-540-45212-6_9. short: A. Chakrabarti, L. De Alfaro, T.A. Henzinger, M. Stoelinga, in:, Third International Conference on Embedded Software, ACM, 2003, pp. 117–133. conference: end_date: 2003-10-15 location: Philadelphia, PA, USA name: 'EMSOFT: Embedded Software ' start_date: 2003-10-13 date_created: 2018-12-11T12:09:29Z date_published: 2003-09-29T00:00:00Z date_updated: 2024-01-08T10:48:11Z day: '29' doi: 10.1007/978-3-540-45212-6_9 extern: '1' intvolume: ' 2855' language: - iso: eng month: '09' oa_version: None page: 117 - 133 publication: Third International Conference on Embedded Software publication_identifier: isbn: - '9783540202233' publication_status: published publisher: ACM publist_id: '148' quality_controlled: '1' scopus_import: '1' status: public title: Resource interfaces type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2855 year: '2003' ... --- _id: '4630' abstract: - lang: eng text: We consider concurrent two-person games played in real time, in which the players decide both which action to play, and when to play it. Such timed games differ from untimed games in two essential ways. First, players can take each other by surprise, because actions are played with delays that cannot be anticipated by the opponent. Second, a player should not be able to win the game by preventing time from diverging. We present a model of timed games that preserves the element of surprise and accounts for time divergence in a way that treats both players symmetrically and applies to all ω-regular winning conditions. We prove that the ability to take each other by surprise adds extra power to the players. For the case that the games are specified in the style of timed automata, we provide symbolic algorithms for their solution with respect to all ω-regular winning conditions. We also show that for these timed games, memory strategies are more powerful than memoryless strategies already in the case of reachability objectives. acknowledgement: Supported in part by the AFOSR MURI grant F49620-00-1-0327, the DARPA grant F33615-C-98-3614, the MARCO grant 98-DT-660, -the ONR grant N00014-02-1-0671, the NSF grants CCR-9988172, CCR-0225610, and CCR-0234690, the NSF CAREER award CCR-0132780, and the MIUR grant MEFISTO. alternative_title: - LNCS article_processing_charge: No author: - first_name: Luca full_name: De Alfaro, Luca last_name: De Alfaro - first_name: Marco full_name: Faella, Marco last_name: Faella - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Ritankar full_name: Majumdar, Ritankar last_name: Majumdar - first_name: Mariëlle full_name: Stoelinga, Mariëlle last_name: Stoelinga citation: ama: 'De Alfaro L, Faella M, Henzinger TA, Majumdar R, Stoelinga M. The element of surprise in timed games. In: Proceedings of the 14th International Conference on Concurrency Theory. Vol 2761. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2003:144-158. doi:10.1007/978-3-540-45187-7_9' apa: 'De Alfaro, L., Faella, M., Henzinger, T. A., Majumdar, R., & Stoelinga, M. (2003). The element of surprise in timed games. In Proceedings of the 14th International Conference on Concurrency Theory (Vol. 2761, pp. 144–158). Marseille, France: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/978-3-540-45187-7_9' chicago: De Alfaro, Luca, Marco Faella, Thomas A Henzinger, Ritankar Majumdar, and Mariëlle Stoelinga. “The Element of Surprise in Timed Games.” In Proceedings of the 14th International Conference on Concurrency Theory, 2761:144–58. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2003. https://doi.org/10.1007/978-3-540-45187-7_9. ieee: L. De Alfaro, M. Faella, T. A. Henzinger, R. Majumdar, and M. Stoelinga, “The element of surprise in timed games,” in Proceedings of the 14th International Conference on Concurrency Theory, Marseille, France, 2003, vol. 2761, pp. 144–158. ista: 'De Alfaro L, Faella M, Henzinger TA, Majumdar R, Stoelinga M. 2003. The element of surprise in timed games. Proceedings of the 14th International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS, vol. 2761, 144–158.' mla: De Alfaro, Luca, et al. “The Element of Surprise in Timed Games.” Proceedings of the 14th International Conference on Concurrency Theory, vol. 2761, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2003, pp. 144–58, doi:10.1007/978-3-540-45187-7_9. short: L. De Alfaro, M. Faella, T.A. Henzinger, R. Majumdar, M. Stoelinga, in:, Proceedings of the 14th International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2003, pp. 144–158. conference: end_date: 2003-09-05 location: Marseille, France name: 'CONCUR: Concurrency Theory' start_date: 2003-09-03 date_created: 2018-12-11T12:09:51Z date_published: 2003-08-21T00:00:00Z date_updated: 2024-01-08T10:05:30Z day: '21' doi: 10.1007/978-3-540-45187-7_9 extern: '1' intvolume: ' 2761' language: - iso: eng month: '08' oa_version: None page: 144 - 158 publication: Proceedings of the 14th International Conference on Concurrency Theory publication_identifier: isbn: - '9783540407539' publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik publist_id: '78' quality_controlled: '1' scopus_import: '1' status: public title: The element of surprise in timed games type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2761 year: '2003' ...