TY - JOUR
AB - Social and solitary feeding in natural Caenorhabditis elegans isolates are associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1: social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V. Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18 and flp-21 genes as NPR-1 ligands and show that these peptides can differentially activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21 deletion partially phenocopied the npr-1(null) phenotype, which is consistent with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands.
AU - Rogers, Candida
AU - Reale, Vincenzina
AU - Kim, Kyuhyung
AU - Chatwin, Heather
AU - Li, Chris
AU - Evans, Peter
AU - de Bono, Mario
ID - 6156
IS - 11
JF - Nature Neuroscience
SN - 1097-6256
TI - Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
VL - 6
ER -
TY - JOUR
AB - In many animal species individuals aggregate to live in groups. A range of experimental approaches in different animals, including studies of social feeding in nematodes, maternal behavior in rats and sheep, and pair-bonding in voles, are providing insights into the neural bases for these behaviors. These studies are delineating multiple neural circuits and gene networks in the brain that interact in ways that are as yet poorly understood to coordinate social behavior.
AU - de Bono, Mario
ID - 6157
IS - 1
JF - Journal of Neurobiology
SN - 0022-3034
TI - Molecular approaches to aggregation behavior and social attachment
VL - 54
ER -
TY - JOUR
AB - Among the major mathematical approaches to mirror symmetry are those of Batyrev-Borisov and Stromdnger-Yau-Zaslow (SYZ). The first is explicit and amenable to computation but is not clearly related to the physical motivation; the second is the opposite. Furthermore, it is far from obvious that mirror partners in one sense will also be mirror partners in the other. This paper concerns a class of examples that can be shown to satisfy the requirements of SYZ, but whose Hodge numbers are also equal. This provides significant evidence in support of SYZ. Moreover, the examples are of great interest in their own right: they are spaces of flat SLr-connections on a smooth curve. The mirror is the corresponding space for the Langlands dual group PGLr. These examples therefore throw a bridge from mirror symmetry to the duality theory of Lie groups and, more broadly, to the geometric Langlands program.
AU - Tamas Hausel
AU - Thaddeus, Michael
ID - 1457
IS - 1
JF - Inventiones Mathematicae
TI - Mirror symmetry, langlands duality, and the Hitchin system
VL - 153
ER -
TY - JOUR
AB - The moduli space of stable bundles of rank $2$ and degree $1$ on a Riemann surface has rational cohomology generated by the so-called universal classes. The work of Baranovsky, King-Newstead, Siebert-Tian and Zagier provided a complete set of relations between these classes, expressed in terms of a recursion in the genus. This paper accomplishes the same thing for the noncompact moduli spaces of Higgs bundles, in the sense of Hitchin and Simpson. There are many more independent relations than for stable bundles, but in a sense the answer is simpler, since the formulas are completely explicit, not recursive. The results of Kirwan on equivariant cohomology for holomorphic circle actions are of key importance.
AU - Tamas Hausel
AU - Thaddeus, Michael
ID - 1458
IS - 2
JF - Journal of the American Mathematical Society
TI - Relations in the cohomology ring of the moduli space of rank 2 Higgs bundles
VL - 16
ER -
TY - JOUR
AB - In this paper we explicitly calculate the analogue of the 't Hooft SU (2) Yang-Mills instantons on Gibbons-Hawking multi-centered gravitational instantons, which come in two parallel families: the multi-Eguchi-Hanson, or Ak ALE gravitational instantons and the multi-Taub-NUT spaces, or Ak ALF gravitational instantons. We calculate their energy and find the reducible ones. Following Kronheimer we also exploit the U(1) invariance of our solutions and study the corresponding explicit singular SU (2) magnetic monopole solutions of the Bogomolny equations on flat ℝ3.
AU - Etesi, Gábor
AU - Tamas Hausel
ID - 1459
IS - 2
JF - Communications in Mathematical Physics
TI - On Yang-Mills instantons over multi-centered gravitational instantons
VL - 235
ER -