[{"publist_id":"1835","extern":"1","year":"2002","acknowledgement":"We thank P. Andolfatto, P. Awadalla, B. Charlesworth, D. Charles- Guillaudeux, T., M. Janer, G. K. S. Wong, T. Spies and D. E. Geraghty, F. Depaulis, S. Otto, J. Rozas, and three anonymous reviewers for valuable discussion and criticism. A.N. is grateful to F. Depaulis, whose comments were particularly helpful (and extremely funny), and to D. Charlesworth, whose ideas made this work readable. This work was supported by Biotechnology and Biological Sciences Research Council/Engineering and Physical Sciences Research Council.","pmid":1,"publication_status":"published","publisher":"Genetics Society of America","author":[{"last_name":"Navarro","first_name":"Arcadio","full_name":"Navarro, Arcadio"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H"}],"date_created":"2018-12-11T12:07:53Z","date_updated":"2023-06-06T12:02:32Z","volume":161,"month":"06","publication_identifier":{"issn":["0016-6731"]},"oa":1,"external_id":{"pmid":["12072479"]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462137/"}],"quality_controlled":"1","doi":"10.1093/genetics/161.2.849","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"lang":"eng","text":"We studied the effect of multilocus balancing selection on neutral nucleotide variability at linked sites by simulating a model where diallelic polymorphisms are maintained at an arbitrary number of selected loci by means of symmetric overdominance. Different combinations of alleles define different genetic backgrounds that subdivide the population and strongly affect variability. Several multilocus fitness regimes with different degrees of epistasis and gametic disequilibrium are allowed. Analytical results based on a multilocus extension of the structured coalescent predict that the expected linked neutral diversity increases exponentially with the number of selected loci and can become extremely large. Our simulation results show that although variability increases with the number of genetic backgrounds that are maintained in the population, it is reduced by random fluctuations in the frequencies of those backgrounds and does not reach high levels even in very large populations. We also show that previous results on balancing selection in single-locus systems do not extend to the multilocus scenario in a straightforward way. Different patterns of linkage disequilibrium and of the frequency spectrum of neutral mutations are expected under different degrees of epistasis. Interestingly, the power to detect balancing selection using deviations from a neutral distribution of allele frequencies seems to be diminished under the fitness regime that leads to the largest increase of variability over the neutral case. This and other results are discussed in the light of data from the Mhc."}],"issue":"2","_id":"4258","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"The effects of multilocus balancing selection on neutral variability","status":"public","intvolume":" 161","oa_version":"Published Version","scopus_import":"1","day":"01","article_processing_charge":"No","publication":"Genetics","citation":{"apa":"Navarro, A., & Barton, N. H. (2002). The effects of multilocus balancing selection on neutral variability. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.2.849","ieee":"A. Navarro and N. H. Barton, “The effects of multilocus balancing selection on neutral variability,” Genetics, vol. 161, no. 2. Genetics Society of America, pp. 849–863, 2002.","ista":"Navarro A, Barton NH. 2002. The effects of multilocus balancing selection on neutral variability. Genetics. 161(2), 849–863.","ama":"Navarro A, Barton NH. The effects of multilocus balancing selection on neutral variability. Genetics. 2002;161(2):849-863. doi:10.1093/genetics/161.2.849","chicago":"Navarro, Arcadio, and Nicholas H Barton. “The Effects of Multilocus Balancing Selection on Neutral Variability.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/161.2.849.","short":"A. Navarro, N.H. Barton, Genetics 161 (2002) 849–863.","mla":"Navarro, Arcadio, and Nicholas H. Barton. “The Effects of Multilocus Balancing Selection on Neutral Variability.” Genetics, vol. 161, no. 2, Genetics Society of America, 2002, pp. 849–63, doi:10.1093/genetics/161.2.849."},"article_type":"original","page":"849 - 863","date_published":"2002-06-01T00:00:00Z"},{"acknowledgement":"The authors thank Toby Johnson for his helpful comments on this manuscript. This work was supported by a National Science Foundation NATO postdoctoral fellowship and National Science Foundation grants DEB-9813335 and DEB-0108242 to M.E.O.; N.H.B. gratefully acknowledges the support of the Darwin Trust of Edinburgh and the National Environmental Research Council.","year":"2002","pmid":1,"publication_status":"published","publisher":"Genetics Society of America","author":[{"full_name":"Orive, Maria","last_name":"Orive","first_name":"Maria"},{"first_name":"Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"date_created":"2018-12-11T12:07:54Z","date_updated":"2023-06-06T12:19:54Z","volume":162,"publist_id":"1836","extern":"1","oa":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462324/"}],"external_id":{"pmid":["12454089"]},"quality_controlled":"1","doi":"10.1093/genetics/162.3.1469","language":[{"iso":"eng"}],"month":"11","publication_identifier":{"issn":["0016-6731"]},"_id":"4259","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","title":"Associations between cytoplasmic and nuclear loci in hybridizing populations","intvolume":" 162","oa_version":"Published Version","type":"journal_article","abstract":[{"text":"We extend current multilocus models to describe the effects of migration, recombination, selection, and nonrandom mating on sets of genes in diploids with varied modes of inheritance, allowing us to consider the patterns of nuclear and cytonuclear associations (disequilibria) under various models of migration. We show the relationship between the multilocus notation recently presented by Kirkpatrick, Johnson, and Barton (developed from previous work by Barton and Turelli) and the cytonuclear parameterization of Asmussen, Arnold, and Avise and extend this notation to describe associations between cytoplasmic elements and multiple nuclear genes. Under models with sexual symmetry, both nuclear-nuclear and cytonuclear disequilibria are equivalent. They differ, however, in cases involving some type of sexual asymmetry, which is then reflected in the asymmetric inheritance of cytoplasmic markers. An example given is the case of different migration rates in males and females; simulations using 2, 3, 4, or 5 unlinked autosomal markers with a maternally inherited cytoplasmic marker illustrate how nuclear-nuclear and cytonuclear associations can be used to separately estimate female and male migration rates. The general framework developed here allows us to investigate conditions where associations between loci with different modes of inheritance are not equivalent and to use this nonequivalence to test for deviations from simple models of admixture. ","lang":"eng"}],"issue":"3","publication":"Genetics","citation":{"short":"M. Orive, N.H. Barton, Genetics 162 (2002) 1469–1485.","mla":"Orive, Maria, and Nicholas H. Barton. “Associations between Cytoplasmic and Nuclear Loci in Hybridizing Populations.” Genetics, vol. 162, no. 3, Genetics Society of America, 2002, pp. 1469–85, doi:10.1093/genetics/162.3.1469.","chicago":"Orive, Maria, and Nicholas H Barton. “Associations between Cytoplasmic and Nuclear Loci in Hybridizing Populations.” Genetics. Genetics Society of America, 2002. https://doi.org/10.1093/genetics/162.3.1469.","ama":"Orive M, Barton NH. Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. 2002;162(3):1469-1485. doi:10.1093/genetics/162.3.1469","apa":"Orive, M., & Barton, N. H. (2002). Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/162.3.1469","ieee":"M. Orive and N. H. Barton, “Associations between cytoplasmic and nuclear loci in hybridizing populations,” Genetics, vol. 162, no. 3. Genetics Society of America, pp. 1469–1485, 2002.","ista":"Orive M, Barton NH. 2002. Associations between cytoplasmic and nuclear loci in hybridizing populations. Genetics. 162(3), 1469–1485."},"article_type":"original","page":"1469 - 1485","date_published":"2002-11-01T00:00:00Z","scopus_import":"1","day":"01","article_processing_charge":"No"},{"issue":"14","abstract":[{"lang":"eng","text":"We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms."}],"type":"journal_article","oa_version":"None","_id":"4209","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":" 129","status":"public","title":"Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A","article_processing_charge":"No","day":"15","scopus_import":"1","date_published":"2002-07-15T00:00:00Z","citation":{"ista":"Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. 2002. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. 129(14), 3493–3503.","ieee":"M. Hannus, F. Feiguin, C.-P. J. Heisenberg, and S. Eaton, “Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A,” Development, vol. 129, no. 14. Company of Biologists, pp. 3493–3503, 2002.","apa":"Hannus, M., Feiguin, F., Heisenberg, C.-P. J., & Eaton, S. (2002). Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. Company of Biologists. https://doi.org/10.1242/dev.129.14.3493","ama":"Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development. 2002;129(14):3493-3503. doi:10.1242/dev.129.14.3493","chicago":"Hannus, Michael, Fabian Feiguin, Carl-Philipp J Heisenberg, and Suzanne Eaton. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” Development. Company of Biologists, 2002. https://doi.org/10.1242/dev.129.14.3493.","mla":"Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit of Protein Phosphatase 2A.” Development, vol. 129, no. 14, Company of Biologists, 2002, pp. 3493–503, doi:10.1242/dev.129.14.3493.","short":"M. Hannus, F. Feiguin, C.-P.J. Heisenberg, S. Eaton, Development 129 (2002) 3493–3503."},"publication":"Development","page":"3493 - 3503","article_type":"original","publist_id":"1909","extern":"1","author":[{"last_name":"Hannus","first_name":"Michael","full_name":"Hannus, Michael"},{"full_name":"Feiguin, Fabian","first_name":"Fabian","last_name":"Feiguin"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"Suzanne","last_name":"Eaton","full_name":"Eaton, Suzanne"}],"volume":129,"date_created":"2018-12-11T12:07:36Z","date_updated":"2023-06-06T14:07:49Z","pmid":1,"acknowledgement":"We gratefully acknowledge Bianca Habermann for assistance with bioinformatics, Jens Rietdorf and Arshad Desai for help with deconvolution, and Tadashi Uemura and Rick Fehon for providing antibodies. Arshad Desai, Christian Dahmann, Tony Hyman and Elly Tanaka provided helpful comments on the manuscript. Part of this work was performed at the EMBL in Heidelberg.","year":"2002","publisher":"Company of Biologists","publication_status":"published","publication_identifier":{"issn":["0950-1991"]},"month":"07","doi":"10.1242/dev.129.14.3493","language":[{"iso":"eng"}],"external_id":{"pmid":["12091318"]},"quality_controlled":"1"},{"_id":"4207","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Wnt signalling: Refocusing on Strabismus","status":"public","intvolume":" 12","oa_version":"None","type":"journal_article","abstract":[{"text":"Vertebrate homologues of the Strabismus/van Gogh (stbm/vang) gene have been implicated in patterning and morphogenesis during gastrulation. Recent work shows that stbm/vang is mutated in zebrafish trilobite mutants and that stbm/vang is required for morphogenesis but not patterning during zebrafish gastrulation.","lang":"eng"}],"issue":"19","publication":"Current Biology","citation":{"chicago":"Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.” Current Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)01160-0.","short":"C.-P.J. Heisenberg, Current Biology 12 (2002) R657–R659.","mla":"Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.” Current Biology, vol. 12, no. 19, Cell Press, 2002, pp. R657–59, doi:10.1016/S0960-9822(02)01160-0.","ieee":"C.-P. J. Heisenberg, “Wnt signalling: Refocusing on Strabismus,” Current Biology, vol. 12, no. 19. Cell Press, pp. R657–R659, 2002.","apa":"Heisenberg, C.-P. J. (2002). Wnt signalling: Refocusing on Strabismus. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)01160-0","ista":"Heisenberg C-PJ. 2002. Wnt signalling: Refocusing on Strabismus. Current Biology. 12(19), R657–R659.","ama":"Heisenberg C-PJ. Wnt signalling: Refocusing on Strabismus. Current Biology. 2002;12(19):R657-R659. doi:10.1016/S0960-9822(02)01160-0"},"article_type":"original","page":"R657 - R659","date_published":"2002-10-01T00:00:00Z","scopus_import":"1","day":"01","article_processing_charge":"No","year":"2002","pmid":1,"publication_status":"published","publisher":"Cell Press","author":[{"last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"}],"date_updated":"2023-06-06T15:09:53Z","date_created":"2018-12-11T12:07:35Z","volume":12,"publist_id":"1912","extern":"1","external_id":{"pmid":["12361585"]},"quality_controlled":"1","doi":"10.1016/S0960-9822(02)01160-0","language":[{"iso":"eng"}],"month":"10","publication_identifier":{"issn":["0960-9822"]}},{"oa_version":"None","_id":"4194","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":" 35","title":"Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling","status":"public","issue":"2","abstract":[{"lang":"eng","text":"Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon."}],"type":"journal_article","date_published":"2002-07-18T00:00:00Z","citation":{"mla":"Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron, vol. 35, no. 2, Elsevier, 2002, pp. 255–65, doi:10.1016/S0896-6273(02)00751-1.","short":"C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S. Wilson, Neuron 35 (2002) 255–265.","chicago":"Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth, Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)00751-1.","ama":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 2002;35(2):255-265. doi:10.1016/S0896-6273(02)00751-1","ista":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2), 255–265.","apa":"Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M., & Wilson, S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)00751-1","ieee":"C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling,” Neuron, vol. 35, no. 2. Elsevier, pp. 255–265, 2002."},"publication":"Neuron","page":"255 - 265","article_type":"original","article_processing_charge":"No","day":"18","scopus_import":"1","author":[{"last_name":"Houart","first_name":"Corinne","full_name":"Houart, Corinne"},{"full_name":"Caneparo, Luca","last_name":"Caneparo","first_name":"Luca"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"},{"last_name":"Barth","first_name":"K Anukampa","full_name":"Barth, K Anukampa"},{"full_name":"Take Uchi, Masaya","first_name":"Masaya","last_name":"Take Uchi"},{"full_name":"Wilson, Stephen","first_name":"Stephen","last_name":"Wilson"}],"volume":35,"date_updated":"2023-06-07T09:43:19Z","date_created":"2018-12-11T12:07:30Z","pmid":1,"acknowledgement":"We thank many of our colleagues, especially Randy Moon, for providing reagents used in this study. This study was supported by the Wellcome Trust, MRC, and BBSRC to S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow.","year":"2002","publisher":"Elsevier","publication_status":"published","publist_id":"1925","extern":"1","doi":"10.1016/S0896-6273(02)00751-1","language":[{"iso":"eng"}],"external_id":{"pmid":["12160744"]},"quality_controlled":"1","publication_identifier":{"issn":["0896-6273"]},"month":"07"},{"type":"journal_article","abstract":[{"lang":"eng","text":"Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, Patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements."}],"issue":"3","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4148","status":"public","title":"Non-canonical Wnt signalling and regulation of gastrulation movements","intvolume":" 13","oa_version":"None","scopus_import":"1","day":"01","article_processing_charge":"No","publication":"Seminars in Cell & Developmental Biology","citation":{"chicago":"Tada, Masazumi, Miguel Concha, and Carl-Philipp J Heisenberg. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” Seminars in Cell & Developmental Biology. Academic Press, 2002. https://doi.org/10.1016/S1084-9521(02)00052-6.","short":"M. Tada, M. Concha, C.-P.J. Heisenberg, Seminars in Cell & Developmental Biology 13 (2002) 251–260.","mla":"Tada, Masazumi, et al. “Non-Canonical Wnt Signalling and Regulation of Gastrulation Movements.” Seminars in Cell & Developmental Biology, vol. 13, no. 3, Academic Press, 2002, pp. 251–60, doi:10.1016/S1084-9521(02)00052-6.","apa":"Tada, M., Concha, M., & Heisenberg, C.-P. J. (2002). Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. Academic Press. https://doi.org/10.1016/S1084-9521(02)00052-6","ieee":"M. Tada, M. Concha, and C.-P. J. Heisenberg, “Non-canonical Wnt signalling and regulation of gastrulation movements,” Seminars in Cell & Developmental Biology, vol. 13, no. 3. Academic Press, pp. 251–260, 2002.","ista":"Tada M, Concha M, Heisenberg C-PJ. 2002. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. 13(3), 251–260.","ama":"Tada M, Concha M, Heisenberg C-PJ. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell & Developmental Biology. 2002;13(3):251-260. doi:10.1016/S1084-9521(02)00052-6"},"article_type":"original","page":"251 - 260","date_published":"2002-06-01T00:00:00Z","publist_id":"1973","extern":"1","year":"2002","acknowledgement":"We would like to thank Steve Wilson for encouraging us to write this article and for critical comments on this manuscript, and Lila Solnica-Krezel for communicating results prior to publication. MT is supported by an MRC Career Development Award, MLC by a Wellcome Trust Fellowship and CPH by an Emmy–Noether–Fellowship from the DFG.","pmid":1,"publication_status":"published","publisher":"Academic Press","author":[{"last_name":"Tada","first_name":"Masazumi","full_name":"Tada, Masazumi"},{"last_name":"Concha","first_name":"Miguel","full_name":"Concha, Miguel"},{"full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"date_created":"2018-12-11T12:07:13Z","date_updated":"2023-06-07T09:50:14Z","volume":13,"month":"06","publication_identifier":{"issn":["1084-9521"]},"external_id":{"pmid":["12137734"]},"quality_controlled":"1","doi":"10.1016/S1084-9521(02)00052-6","language":[{"iso":"eng"}]},{"issue":"6","abstract":[{"lang":"eng","text":"During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements."}],"type":"journal_article","oa_version":"None","intvolume":" 13","title":"Zebrafish gastrulation movements: bridging cell and developmental biology","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4196","article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2002-12-01T00:00:00Z","page":"471 - 479","article_type":"original","citation":{"ama":"Heisenberg C-PJ, Tada M. Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. 2002;13(6):471-479. doi:10.1016/S1084952102001003","apa":"Heisenberg, C.-P. J., & Tada, M. (2002). Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. Academic Press. https://doi.org/10.1016/S1084952102001003","ieee":"C.-P. J. Heisenberg and M. Tada, “Zebrafish gastrulation movements: bridging cell and developmental biology,” Seminars in Cell & Developmental Biology, vol. 13, no. 6. Academic Press, pp. 471–479, 2002.","ista":"Heisenberg C-PJ, Tada M. 2002. Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology. 13(6), 471–479.","short":"C.-P.J. Heisenberg, M. Tada, Seminars in Cell & Developmental Biology 13 (2002) 471–479.","mla":"Heisenberg, Carl-Philipp J., and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” Seminars in Cell & Developmental Biology, vol. 13, no. 6, Academic Press, 2002, pp. 471–79, doi:10.1016/S1084952102001003.","chicago":"Heisenberg, Carl-Philipp J, and Masazumi Tada. “Zebrafish Gastrulation Movements: Bridging Cell and Developmental Biology.” Seminars in Cell & Developmental Biology. Academic Press, 2002. https://doi.org/10.1016/S1084952102001003."},"publication":"Seminars in Cell & Developmental Biology","extern":"1","publist_id":"1920","volume":13,"date_updated":"2023-06-07T09:28:48Z","date_created":"2018-12-11T12:07:31Z","author":[{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J"},{"full_name":"Tada, Masazumi","first_name":"Masazumi","last_name":"Tada"}],"publisher":"Academic Press","publication_status":"published","pmid":1,"year":"2002","acknowledgement":"We would like to thank Miguel Concha, Will Norton, Tim Geach, Suzanne Eaton, Kimbo Kotovic, Jenny Geiger and Steve Wilson for critical comments on this manuscript, and Lila Solnica-Krezel for providing results prior to publication. C.-P.H. is supported by an Emmy-Noether-Fellowship from the DFG and M.T. by an MRC Career Development Award.","publication_identifier":{"issn":["1084-9521"]},"month":"12","language":[{"iso":"eng"}],"doi":"10.1016/S1084952102001003","quality_controlled":"1","external_id":{"pmid":["12468250"]}},{"oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4199","title":"Wnt signalling: A moving picture emerges from van gogh","status":"public","intvolume":" 12","abstract":[{"text":"Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm) gene, a key player in planar cell polarity signalling in Drosophila, show that vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation where it modulates two distinct Wnt signals.","lang":"eng"}],"issue":"4","type":"journal_article","date_published":"2002-02-19T00:00:00Z","publication":"Current Biology","citation":{"chicago":"Heisenberg, Carl-Philipp J, and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” Current Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)00704-2.","mla":"Heisenberg, Carl-Philipp J., and Masazumi Tada. “Wnt Signalling: A Moving Picture Emerges from van Gogh.” Current Biology, vol. 12, no. 4, Cell Press, 2002, pp. R126–28, doi:10.1016/S0960-9822(02)00704-2.","short":"C.-P.J. Heisenberg, M. Tada, Current Biology 12 (2002) R126–R128.","ista":"Heisenberg C-PJ, Tada M. 2002. Wnt signalling: A moving picture emerges from van gogh. Current Biology. 12(4), R126–R128.","ieee":"C.-P. J. Heisenberg and M. Tada, “Wnt signalling: A moving picture emerges from van gogh,” Current Biology, vol. 12, no. 4. Cell Press, pp. R126–R128, 2002.","apa":"Heisenberg, C.-P. J., & Tada, M. (2002). Wnt signalling: A moving picture emerges from van gogh. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00704-2","ama":"Heisenberg C-PJ, Tada M. Wnt signalling: A moving picture emerges from van gogh. Current Biology. 2002;12(4):R126-R128. doi:10.1016/S0960-9822(02)00704-2"},"article_type":"original","page":"R126 - R128","day":"19","article_processing_charge":"No","scopus_import":"1","author":[{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J"},{"full_name":"Tada, Masazumi","first_name":"Masazumi","last_name":"Tada"}],"date_updated":"2023-06-07T08:54:35Z","date_created":"2018-12-11T12:07:32Z","volume":12,"year":"2002","pmid":1,"publication_status":"published","publisher":"Cell Press","publist_id":"1919","extern":"1","doi":"10.1016/S0960-9822(02)00704-2","language":[{"iso":"eng"}],"external_id":{"pmid":["11864583"]},"quality_controlled":"1","month":"02","publication_identifier":{"issn":["0960-9822"]}},{"article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2002-01-01T00:00:00Z","citation":{"ama":"Polechova J, Stopka P. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 2002;80(8):1383-1388. doi:10.1139/z02-128","apa":"Polechova, J., & Stopka, P. (2002). Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. NRC Research Press. https://doi.org/10.1139/z02-128","ieee":"J. Polechova and P. Stopka, “Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus,” Canadian Journal of Zoology, vol. 80, no. 8. NRC Research Press, pp. 1383–1388, 2002.","ista":"Polechova J, Stopka P. 2002. Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 80(8), 1383–1388.","short":"J. Polechova, P. Stopka, Canadian Journal of Zoology 80 (2002) 1383–1388.","mla":"Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” Canadian Journal of Zoology, vol. 80, no. 8, NRC Research Press, 2002, pp. 1383–88, doi:10.1139/z02-128.","chicago":"Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old World Wood Mouse, Apodemus Sylvaticus.” Canadian Journal of Zoology. NRC Research Press, 2002. https://doi.org/10.1139/z02-128."},"publication":"Canadian Journal of Zoology","page":"1383 - 1388","article_type":"original","issue":"8","abstract":[{"text":"Pilot studies in England by Stopka and Macdonald revealed that allogrooming in the Old World wood mouse, Apodemus sylvaticus, is a commodity that males can trade for reproductive benefits with females. This study, which used a combination of field study and observations in experimental enclosures, revealed that specific experimental conditions such as group-size and sex-ratio manipulations have a significant effect on the pattern of allogrooming exchanged between individuals. Furthermore, females from the Czech population were more likely to associate with each other as revealed by the clustering of activity centers of females (i.e., as opposed to almost exclusive ranges in English populations), and also by the higher intensity of allogrooming exchanged between females (i.e., virtually lacking in the previous experiment with English mice). Therefore, geographic variation and specific social conditions seem to be important driving factors for allogrooming behavior. Together with changes in overall grooming patterns, allogrooming between males and females remained invariably asymmetrical over all four experimental groups (i.e., two conditions for each sex) in that males provided more allogrooming to females than they received from them.","lang":"eng"}],"type":"journal_article","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"4139","intvolume":" 80","status":"public","title":"Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus","publication_identifier":{"issn":["0008-4301"]},"month":"01","doi":"10.1139/z02-128","language":[{"iso":"eng"}],"quality_controlled":"1","publist_id":"1981","extern":"1","author":[{"id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0951-3112","first_name":"Jitka","last_name":"Polechova","full_name":"Polechova, Jitka"},{"full_name":"Stopka, P.","first_name":"P.","last_name":"Stopka"}],"volume":80,"date_created":"2018-12-11T12:07:10Z","date_updated":"2023-06-07T12:53:35Z","year":"2002","publisher":"NRC Research Press","publication_status":"published"},{"language":[{"iso":"eng"}],"date_published":"2002-01-01T00:00:00Z","conference":{"end_date":"2002-01-08","start_date":"2002-01-06","location":"San Francisco, CA, USA","name":"SODA: Symposium on Discrete Algorithms"},"page":"791 - 799","quality_controlled":"1","citation":{"mla":"Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.” Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–99.","short":"P. Agarwal, H. Edelsbrunner, Y. Wang, in:, Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–799.","chicago":"Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing Number of a Polygonal Knot.” In Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms, 791–99. SIAM, 2002.","ama":"Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal knot. In: Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms. SIAM; 2002:791-799.","ista":"Agarwal P, Edelsbrunner H, Wang Y. 2002. Computing the writhing number of a polygonal knot. Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 791–799.","apa":"Agarwal, P., Edelsbrunner, H., & Wang, Y. (2002). Computing the writhing number of a polygonal knot. In Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms (pp. 791–799). San Francisco, CA, USA: SIAM.","ieee":"P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of a polygonal knot,” in Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms, San Francisco, CA, USA, 2002, pp. 791–799."},"main_file_link":[{"url":"https://dl.acm.org/doi/10.5555/545381.545485"}],"publication":"Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms","publication_identifier":{"isbn":["9780898715132"]},"article_processing_charge":"No","month":"01","day":"01","scopus_import":"1","oa_version":"None","date_updated":"2023-06-07T13:50:04Z","date_created":"2018-12-11T12:06:23Z","author":[{"last_name":"Agarwal","first_name":"Pankaj","full_name":"Agarwal, Pankaj"},{"first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert"},{"first_name":"Yusu","last_name":"Wang","full_name":"Wang, Yusu"}],"publisher":"SIAM","title":"Computing the writhing number of a polygonal knot","publication_status":"published","status":"public","_id":"4003","acknowledgement":"NSF under grants CCR-00-86013 and EIA-9972879, NSF under grant CCR-97-12088.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"2002","extern":"1","publist_id":"2125","abstract":[{"lang":"eng","text":"The writhing number measures the global geometry of a closed space curve or knot. We show that this measure is related to the average winding number of its Gauss map. Using this relationship, we give an algorithm for computing the writhing number for a polygonal knot with n edges in time roughly proportional to n(1.6). We also implement a different, simple algorithm and provide experimental evidence for its practical efficiency."}],"type":"conference"},{"acknowledgement":"This article is based on the report of the Workshop on Algorithmic Issues in Modeling Motion, sponsored\r\nby an NSF grant CCR-00-83-033 and an Army Research Office grant DAAD 19-00-1-0478, held on August 6\r\nand 7, 2000 at Duke University, Durham, NC.","year":"2002","publication_status":"published","publisher":"ACM","author":[{"full_name":"Agarwal, Pankaj","first_name":"Pankaj","last_name":"Agarwal"},{"full_name":"Guibas, Leonidas","last_name":"Guibas","first_name":"Leonidas"},{"orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert"},{"first_name":"Jeff","last_name":"Erickson","full_name":"Erickson, Jeff"},{"last_name":"Isard","first_name":"Michael","full_name":"Isard, Michael"},{"full_name":"Har Peled, Sariel","first_name":"Sariel","last_name":"Har Peled"},{"full_name":"Hershberger, John","last_name":"Hershberger","first_name":"John"},{"first_name":"Christian","last_name":"Jensen","full_name":"Jensen, Christian"},{"last_name":"Kavraki","first_name":"Lydia","full_name":"Kavraki, Lydia"},{"full_name":"Koehl, Patrice","first_name":"Patrice","last_name":"Koehl"},{"first_name":"Ming","last_name":"Lin","full_name":"Lin, Ming"},{"first_name":"Dinesh","last_name":"Manocha","full_name":"Manocha, Dinesh"},{"full_name":"Metaxas, Dimitris","last_name":"Metaxas","first_name":"Dimitris"},{"full_name":"Mirtich, Brian","first_name":"Brian","last_name":"Mirtich"},{"full_name":"Mount, David","last_name":"Mount","first_name":"David"},{"full_name":"Muthukrishnan, Sankara","first_name":"Sankara","last_name":"Muthukrishnan"},{"full_name":"Pai, Dinesh","first_name":"Dinesh","last_name":"Pai"},{"first_name":"Elisha","last_name":"Sacks","full_name":"Sacks, Elisha"},{"full_name":"Snoeyink, Jack","first_name":"Jack","last_name":"Snoeyink"},{"last_name":"Suri","first_name":"Subhash","full_name":"Suri, Subhash"},{"first_name":"Ouri","last_name":"Wolefson","full_name":"Wolefson, Ouri"}],"date_updated":"2023-06-13T11:34:25Z","date_created":"2018-12-11T12:06:20Z","volume":34,"publist_id":"2129","extern":"1","quality_controlled":"1","doi":"10.1145/592642.592647","language":[{"iso":"eng"}],"month":"12","publication_identifier":{"issn":["0360-0300"]},"_id":"3995","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","title":"Algorithmic issues in modeling motion","intvolume":" 34","oa_version":"None","type":"journal_article","abstract":[{"text":"This article is a survey of research areas in which motion plays a pivotal role. The aim of the article is to review current approaches to modeling motion together with related data structures and algorithms, and to summarize the challenges that lie ahead in producing a more unified theory of motion representation that would be useful across several disciplines.","lang":"eng"}],"issue":"4","publication":"ACM Computing Surveys","citation":{"mla":"Agarwal, Pankaj, et al. “Algorithmic Issues in Modeling Motion.” ACM Computing Surveys, vol. 34, no. 4, ACM, 2002, pp. 550–72, doi:10.1145/592642.592647.","short":"P. Agarwal, L. Guibas, H. Edelsbrunner, J. Erickson, M. Isard, S. Har Peled, J. Hershberger, C. Jensen, L. Kavraki, P. Koehl, M. Lin, D. Manocha, D. Metaxas, B. Mirtich, D. Mount, S. Muthukrishnan, D. Pai, E. Sacks, J. Snoeyink, S. Suri, O. Wolefson, ACM Computing Surveys 34 (2002) 550–572.","chicago":"Agarwal, Pankaj, Leonidas Guibas, Herbert Edelsbrunner, Jeff Erickson, Michael Isard, Sariel Har Peled, John Hershberger, et al. “Algorithmic Issues in Modeling Motion.” ACM Computing Surveys. ACM, 2002. https://doi.org/10.1145/592642.592647.","ama":"Agarwal P, Guibas L, Edelsbrunner H, et al. Algorithmic issues in modeling motion. ACM Computing Surveys. 2002;34(4):550-572. doi:10.1145/592642.592647","ista":"Agarwal P, Guibas L, Edelsbrunner H, Erickson J, Isard M, Har Peled S, Hershberger J, Jensen C, Kavraki L, Koehl P, Lin M, Manocha D, Metaxas D, Mirtich B, Mount D, Muthukrishnan S, Pai D, Sacks E, Snoeyink J, Suri S, Wolefson O. 2002. Algorithmic issues in modeling motion. ACM Computing Surveys. 34(4), 550–572.","ieee":"P. Agarwal et al., “Algorithmic issues in modeling motion,” ACM Computing Surveys, vol. 34, no. 4. ACM, pp. 550–572, 2002.","apa":"Agarwal, P., Guibas, L., Edelsbrunner, H., Erickson, J., Isard, M., Har Peled, S., … Wolefson, O. (2002). Algorithmic issues in modeling motion. ACM Computing Surveys. ACM. https://doi.org/10.1145/592642.592647"},"article_type":"original","page":"550 - 572","date_published":"2002-12-01T00:00:00Z","scopus_import":"1","day":"01","article_processing_charge":"No"},{"extern":"1","publist_id":"2128","date_created":"2018-12-11T12:06:22Z","date_updated":"2023-06-13T11:20:09Z","volume":12,"author":[{"last_name":"Zomorodian","first_name":"Afra","full_name":"Zomorodian, Afra"},{"full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833"}],"publication_status":"published","publisher":"World Scientific Publishing","acknowledgement":"Center for Simulation of Advanced Rockets funded by the U.S. Department of Energy under Subcontract B341494, NSF under grant CCR-96-19542 and ARO under grant DAAG55-98-1-0177.","year":"2002","month":"01","publication_identifier":{"issn":["0218-1959"]},"language":[{"iso":"eng"}],"doi":"10.1142/S0218195902000785","quality_controlled":"1","abstract":[{"lang":"eng","text":"We present fast implementations of a hybrid algorithm for reporting box and cube intersections. Our algorithm initially takes a divide-and-conquer approach and switches to simpler algorithms for low numbers of boxes. We use our implementations as engines to solve problems about geometric primitives. We look at two such problems in the category of quality analysis of surface triangulations."}],"issue":"1-2","type":"journal_article","oa_version":"None","title":"Fast software for box intersections","status":"public","intvolume":" 12","_id":"4000","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","article_processing_charge":"No","scopus_import":"1","date_published":"2002-01-01T00:00:00Z","article_type":"original","page":"143 - 172","publication":"International Journal of Computational Geometry and Applications","citation":{"chicago":"Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” International Journal of Computational Geometry and Applications. World Scientific Publishing, 2002. https://doi.org/10.1142/S0218195902000785.","short":"A. Zomorodian, H. Edelsbrunner, International Journal of Computational Geometry and Applications 12 (2002) 143–172.","mla":"Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.” International Journal of Computational Geometry and Applications, vol. 12, no. 1–2, World Scientific Publishing, 2002, pp. 143–72, doi:10.1142/S0218195902000785.","ieee":"A. Zomorodian and H. Edelsbrunner, “Fast software for box intersections,” International Journal of Computational Geometry and Applications, vol. 12, no. 1–2. World Scientific Publishing, pp. 143–172, 2002.","apa":"Zomorodian, A., & Edelsbrunner, H. (2002). Fast software for box intersections. International Journal of Computational Geometry and Applications. World Scientific Publishing. https://doi.org/10.1142/S0218195902000785","ista":"Zomorodian A, Edelsbrunner H. 2002. Fast software for box intersections. International Journal of Computational Geometry and Applications. 12(1–2), 143–172.","ama":"Zomorodian A, Edelsbrunner H. Fast software for box intersections. International Journal of Computational Geometry and Applications. 2002;12(1-2):143-172. doi:10.1142/S0218195902000785"}},{"issue":"3","abstract":[{"text":"We present results on a two-step improvement of mesh quality in three-dimensional Delaunay triangulations. The first step refines the triangulation by inserting sinks and eliminates tetrahedra with large circumradius over shortest edge length ratio. The second step assigns weights to the vertices to eliminate slivers. Our experimental findings provide evidence for the practical effectiveness of sliver exudation.","lang":"eng"}],"type":"journal_article","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"3998","intvolume":" 18","status":"public","title":"An experimental study of sliver exudation","article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2002-10-01T00:00:00Z","citation":{"mla":"Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” Engineering with Computers, vol. 18, no. 3, Springer, 2002, pp. 229–40, doi:10.1007/s003660200020.","short":"H. Edelsbrunner, D. Guoy, Engineering with Computers 18 (2002) 229–240.","chicago":"Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.” Engineering with Computers. Springer, 2002. https://doi.org/10.1007/s003660200020.","ama":"Edelsbrunner H, Guoy D. An experimental study of sliver exudation. Engineering with Computers. 2002;18(3):229-240. doi:10.1007/s003660200020","ista":"Edelsbrunner H, Guoy D. 2002. An experimental study of sliver exudation. Engineering with Computers. 18(3), 229–240.","ieee":"H. Edelsbrunner and D. Guoy, “An experimental study of sliver exudation,” Engineering with Computers, vol. 18, no. 3. Springer, pp. 229–240, 2002.","apa":"Edelsbrunner, H., & Guoy, D. (2002). An experimental study of sliver exudation. Engineering with Computers. Springer. https://doi.org/10.1007/s003660200020"},"publication":"Engineering with Computers","page":"229 - 240","article_type":"original","publist_id":"2126","extern":"1","author":[{"full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833"},{"full_name":"Guoy, Damrong","last_name":"Guoy","first_name":"Damrong"}],"volume":18,"date_created":"2018-12-11T12:06:21Z","date_updated":"2023-06-13T11:14:44Z","year":"2002","acknowledgement":"NSF under grants CCR-97-12088 and DMS 98-73945, NSF under grands EIA-9972879 and CCR-00-86013 and by ARO under grant DAAG55-98-1- 0177.","publisher":"Springer","publication_status":"published","publication_identifier":{"issn":["0177-0667"]},"month":"10","doi":"10.1007/s003660200020","language":[{"iso":"eng"}],"quality_controlled":"1"},{"scopus_import":"1","day":"01","article_processing_charge":"No","article_type":"original","page":"10593 - 10602","publication":"Journal of Neuroscience","citation":{"ieee":"J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons,” Journal of Neuroscience, vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002.","apa":"Bischofberger, J., Geiger, J., & Jonas, P. M. (2002). Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002","ista":"Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24), 10593–10602.","ama":"Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 2002;22(24):10593-10602. doi:10.1523/JNEUROSCI.22-24-10593.2002","chicago":"Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002.","short":"J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002) 10593–10602.","mla":"Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience, vol. 22, no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:10.1523/JNEUROSCI.22-24-10593.2002."},"date_published":"2002-12-01T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"The presynaptic Ca2+ signal is a key determinant of transmitter release at chemical synapses. In cortical synaptic terminals, however, little is known about the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately 100 pA at a membrane potential of 0 mV. Both activation and deactivation were fast, with time constants in the submillisecond range at a temperature of approximately 23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command evoked a transient Ca2+ current with an average amplitude of approximately 170 pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the voltage-gated Ca2+ channels very effectively. On the basis of the experimental data, we developed a kinetic model with four closed states and one open state, linked by voltage-dependent rate constants. Simulations of the Ca2+ current could reproduce the experimental data, including the large amplitude and rapid time course of the current evoked by MFB APs. Furthermore, the simulations indicate that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels are tuned to produce a maximal Ca2+ influx during a minimal period of time. The precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic synapse may be important for synchronous transmitter release and temporal information processing."}],"issue":"24","title":"Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber boutons","status":"public","intvolume":" 22","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"3802","oa_version":"Published Version","month":"12","publication_identifier":{"issn":["0270-6474"]},"quality_controlled":"1","external_id":{"pmid":["12486151"]},"oa":1,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/","open_access":"1"}],"language":[{"iso":"eng"}],"doi":"10.1523/JNEUROSCI.22-24-10593.2002","extern":"1","publist_id":"2407","publication_status":"published","publisher":"Society for Neuroscience","year":"2002","acknowledgement":"J.B. was supported by grants from the Deutsche Forschungsgemeinschaft (Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp and K. Winterhalter for technical assistance.","pmid":1,"date_updated":"2023-06-13T13:19:45Z","date_created":"2018-12-11T12:05:15Z","volume":22,"author":[{"last_name":"Bischofberger","first_name":"Josef","full_name":"Bischofberger, Josef"},{"last_name":"Geiger","first_name":"Jörg","full_name":"Geiger, Jörg"},{"full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"}]},{"scopus_import":"1","article_processing_charge":"No","day":"22","citation":{"mla":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:10.1098/rspb.2001.1892.","short":"S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B Biological Sciences 269 (2002) 417–422.","chicago":"Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males: Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.” Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The, 2002. https://doi.org/10.1098/rspb.2001.1892.","ama":"Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 2002;269(1489):417-422. doi:10.1098/rspb.2001.1892","ista":"Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.","apa":"Cremer, S., & Heinze, J. (2002). Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The. https://doi.org/10.1098/rspb.2001.1892","ieee":"S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 269, no. 1489. Royal Society, The, pp. 417–422, 2002."},"publication":"Proceedings of the Royal Society of London Series B Biological Sciences","page":"417 - 422","article_type":"original","date_published":"2002-02-22T00:00:00Z","type":"journal_article","issue":"1489","abstract":[{"lang":"eng","text":"Hamilton's concept of local mate competition (LMC) is the standard model to explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera, however, LMC has remained controversial, mainly because manipulation of sex allocation by workers in response to relatedness asymmetries is an additional powerful mechanism of female bias. Furthermore, the predominant mating systems in the social insects are thought to make LMC unlikely. Nevertheless, several species exist in which dispersal of males is limited and mating occurs in the nest. Some of these species, such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one morph being specialized for dispersal and the other for fighting with nest-mate males over access to females. Such life history, combining sociality and alternative reproductive tactics in males, provides a unique opportunity to test the power of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera. We show that, in concordance with LMC predictions, an experimental increase in queen number leads to a shift in sex allocation in favour of non-dispersing males, but does not influence the proportion of disperser males. Furthermore, we can assign this change in sex allocation at the colony level to the queens and rule out worker manipulation."}],"_id":"3919","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":" 269","status":"public","title":"Adaptive production of fighter males: queens of the ant Cardiocondyla adjust the sex ratio under local mate competition","oa_version":"None","publication_identifier":{"issn":["0962-8452"]},"month":"02","external_id":{"pmid":["11886631"]},"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/"}],"oa":1,"quality_controlled":"1","doi":"10.1098/rspb.2001.1892","language":[{"iso":"eng"}],"publist_id":"2231","extern":"1","pmid":1,"year":"2002","acknowledgement":"We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C. Anderson and C. Schubart for improving the manuscript, and E. Sixt for ant illustrations (figure 2). This study was funded by the DFG (Deutsche Forschungsgemeinschaft: He1623/7-2).","publisher":"Royal Society, The","publication_status":"published","author":[{"last_name":"Cremer","first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"volume":269,"date_created":"2018-12-11T12:05:53Z","date_updated":"2023-06-13T11:52:17Z"},{"date_published":"2002-04-05T00:00:00Z","page":"221 - 228","article_type":"original","citation":{"ama":"Cremer S, Lautenschläger B, Heinze J. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. 2002;49(3):221-228. doi:10.1007/s00040-002-8305-z","apa":"Cremer, S., Lautenschläger, B., & Heinze, J. (2002). A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. Springer. https://doi.org/10.1007/s00040-002-8305-z","ieee":"S. Cremer, B. Lautenschläger, and J. Heinze, “A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior,” Insectes Sociaux, vol. 49, no. 3. Springer, pp. 221–228, 2002.","ista":"Cremer S, Lautenschläger B, Heinze J. 2002. A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux. 49(3), 221–228.","short":"S. Cremer, B. Lautenschläger, J. Heinze, Insectes Sociaux 49 (2002) 221–228.","mla":"Cremer, Sylvia, et al. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” Insectes Sociaux, vol. 49, no. 3, Springer, 2002, pp. 221–28, doi:10.1007/s00040-002-8305-z.","chicago":"Cremer, Sylvia, Birgit Lautenschläger, and Jürgen Heinze. “A Transitional Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.” Insectes Sociaux. Springer, 2002. https://doi.org/10.1007/s00040-002-8305-z."},"publication":"Insectes Sociaux","article_processing_charge":"No","day":"05","scopus_import":"1","oa_version":"None","intvolume":" 49","title":"A transitional stage between the ergatoid and winged male morph in the ant Cardiocondyla obscurior","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"3924","issue":"3","abstract":[{"lang":"eng","text":"Males of the ant Cardiocondyla show a dispersal dimorphism of a winged and wingless morph. The loss of flight has lead to morphological reductions in the wingless (ergatoid) males and also affected body size, eye size and pigmentation. As ergatoid males mate exclusively inside the maternal nest, they underlie increased male-male competition and therefore have also evolved additional changes in behaviour and physiology: in contrast to winged males, ergatoid males are highly aggressive towards each other and their spermatogenesis is prolonged compared to all other hymenopteran males. In addition to these two male morphs, we found males with an intermediate appearance. These "intermorphic" males provide a transitional stage between normal males in most investigated morphological and physiological parameters. As they are produced extremely rarely and only in colonies that switch between pure ergatoid to mixed male production, we argue that they likely represent a developmental mistake. Parallels between the determination of male morphs and female castes (queen-worker dimorphism and worker polymorphism) might help to understand how the large potential of phenotypic plasticity in both sexes of social insects is realised during development."}],"type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1007/s00040-002-8305-z","quality_controlled":"1","publication_identifier":{"issn":["0020-1812"]},"month":"04","volume":49,"date_created":"2018-12-11T12:05:55Z","date_updated":"2023-06-13T11:44:08Z","author":[{"full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer"},{"first_name":"Birgit","last_name":"Lautenschläger","full_name":"Lautenschläger, Birgit"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"publisher":"Springer","publication_status":"published","acknowledgement":"We would like to thank S. Karpeles for histological analysis of the winged males and S. Buchhauser for help with the photographs. This study was funded by the DFG (grant He1623/12–1).","year":"2002","extern":"1","publist_id":"2229"},{"language":[{"iso":"eng"}],"doi":"10.1038/419897a","quality_controlled":"1","external_id":{"pmid":["12410300"]},"month":"10","publication_identifier":{"issn":["0028-0836"]},"date_created":"2018-12-11T12:05:55Z","date_updated":"2023-06-13T11:47:19Z","volume":419,"author":[{"full_name":"Cremer, Sylvia","first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"},{"full_name":"Sledge, Matthew","last_name":"Sledge","first_name":"Matthew"},{"first_name":"Jürgen","last_name":"Heinze","full_name":"Heinze, Jürgen"}],"publication_status":"published","publisher":"Nature Publishing Group","year":"2002","pmid":1,"extern":"1","publist_id":"2230","date_published":"2002-10-31T00:00:00Z","article_type":"original","page":"897 - 897","publication":"Nature","citation":{"ama":"Cremer S, Sledge M, Heinze J. Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. 2002;419:897-897. doi:10.1038/419897a","ista":"Cremer S, Sledge M, Heinze J. 2002. Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. 419, 897–897.","apa":"Cremer, S., Sledge, M., & Heinze, J. (2002). Chemical mimicry: Male ants disguised by the queen’s bouquet. Nature. Nature Publishing Group. https://doi.org/10.1038/419897a","ieee":"S. Cremer, M. Sledge, and J. Heinze, “Chemical mimicry: Male ants disguised by the queen’s bouquet,” Nature, vol. 419. Nature Publishing Group, pp. 897–897, 2002.","mla":"Cremer, Sylvia, et al. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” Nature, vol. 419, Nature Publishing Group, 2002, pp. 897–897, doi:10.1038/419897a.","short":"S. Cremer, M. Sledge, J. Heinze, Nature 419 (2002) 897–897.","chicago":"Cremer, Sylvia, Matthew Sledge, and Jürgen Heinze. “Chemical Mimicry: Male Ants Disguised by the Queen’s Bouquet.” Nature. Nature Publishing Group, 2002. https://doi.org/10.1038/419897a."},"day":"31","article_processing_charge":"No","scopus_import":"1","oa_version":"None","title":"Chemical mimicry: Male ants disguised by the queen's bouquet","status":"public","intvolume":" 419","_id":"3925","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","abstract":[{"text":"Males of the tropical ant Cardiocondyla obscurior are either wingless and aggressive or winged and docile, and both compete for access to virgin queens in the nest1, 2. Although the fighter males (ergatoids) attack and kill other ergatoids, they tolerate and even attempt to mate with their winged rivals. Here we show that the winged males avoid the aggression of wingless males by mimicking the chemical bouquet of virgin queens, but that their mating success is not reduced as a result. This example of female mimicry by vigorous males is surprising, as in other species it is typically used as a protective strategy by weaker males, and may explain the coexistence and equal mating success of two male morphs.","lang":"eng"}],"type":"journal_article"},{"oa_version":"None","_id":"3996","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","intvolume":" 28","status":"public","title":"Topological persistence and simplification","issue":"4","abstract":[{"text":"We formalize a notion of topological simplification within the framework of a filtration, which is the history of a growing complex. We classify a topological change that happens during growth as either a feature or noise depending on its lifetime or persistence within the filtration. We give fast algorithms for computing persistence and experimental evidence for their speed and utility.","lang":"eng"}],"type":"journal_article","date_published":"2002-12-01T00:00:00Z","citation":{"mla":"Edelsbrunner, Herbert, et al. “Topological Persistence and Simplification.” Discrete & Computational Geometry, vol. 28, no. 4, Springer, 2002, pp. 511–33, doi:10.1007/s00454-002-2885-2.","short":"H. Edelsbrunner, D. Letscher, A. Zomorodian, Discrete & Computational Geometry 28 (2002) 511–533.","chicago":"Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological Persistence and Simplification.” Discrete & Computational Geometry. Springer, 2002. https://doi.org/10.1007/s00454-002-2885-2.","ama":"Edelsbrunner H, Letscher D, Zomorodian A. Topological persistence and simplification. Discrete & Computational Geometry. 2002;28(4):511-533. doi:10.1007/s00454-002-2885-2","ista":"Edelsbrunner H, Letscher D, Zomorodian A. 2002. Topological persistence and simplification. Discrete & Computational Geometry. 28(4), 511–533.","ieee":"H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistence and simplification,” Discrete & Computational Geometry, vol. 28, no. 4. Springer, pp. 511–533, 2002.","apa":"Edelsbrunner, H., Letscher, D., & Zomorodian, A. (2002). Topological persistence and simplification. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-002-2885-2"},"publication":"Discrete & Computational Geometry","page":"511 - 533","article_type":"original","article_processing_charge":"No","day":"01","scopus_import":"1","author":[{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","first_name":"Herbert","last_name":"Edelsbrunner"},{"full_name":"Letscher, David","last_name":"Letscher","first_name":"David"},{"full_name":"Zomorodian, Afra","last_name":"Zomorodian","first_name":"Afra"}],"volume":28,"date_created":"2018-12-11T12:06:20Z","date_updated":"2023-06-13T11:41:19Z","year":"2002","acknowledgement":"We thank Jeff Erickson and John Harer for helpful discussions during early stages of this\r\npaper. We also thank Daniel Huson for the zeolite dataset Z, Thomas LaBean for the DNA\r\ndataset D, and the Stanford Graphics Lab for the Buddha dataset S. To generate the bone\r\ndataset B, we sampled an iso-surface generated by Dominique Attali. The volume data\r\nTopological Persistence and Simplification 533 was provided by Francoise Peyrin from CNRS CREATIS in Lyon and was issued from ¸ Synchrotron Radiation Microtomography from the ID19 beamline at ESRF in Grenoble.\r\nWe generated Fig. 17 using the Protein Explorer [6].","publisher":"Springer","publication_status":"published","publist_id":"2130","extern":"1","doi":"10.1007/s00454-002-2885-2","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0179-5376"]},"month":"12"},{"day":"01","month":"01","article_processing_charge":"No","publication":"Insect Social Life","citation":{"ama":"Turillazzi S, Sledge M, Cremer S, Heinze J. A method for analysing small-size specimens in GC-MS. Insect Social Life. 2002;4:169-175.","ieee":"S. Turillazzi, M. Sledge, S. Cremer, and J. Heinze, “A method for analysing small-size specimens in GC-MS,” Insect Social Life, vol. 4. Elsevier, pp. 169–175, 2002.","apa":"Turillazzi, S., Sledge, M., Cremer, S., & Heinze, J. (2002). A method for analysing small-size specimens in GC-MS. Insect Social Life. Elsevier.","ista":"Turillazzi S, Sledge M, Cremer S, Heinze J. 2002. A method for analysing small-size specimens in GC-MS. Insect Social Life. 4, 169–175.","short":"S. Turillazzi, M. Sledge, S. Cremer, J. Heinze, Insect Social Life 4 (2002) 169–175.","mla":"Turillazzi, Stefano, et al. “A Method for Analysing Small-Size Specimens in GC-MS.” Insect Social Life, vol. 4, Elsevier, 2002, pp. 169–75.","chicago":"Turillazzi, Stefano, Matthew Sledge, Sylvia Cremer, and Jürgen Heinze. “A Method for Analysing Small-Size Specimens in GC-MS.” Insect Social Life. Elsevier, 2002."},"article_type":"original","quality_controlled":"1","page":"169 - 175","date_published":"2002-01-01T00:00:00Z","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"lang":"eng","text":"A particular Solid Injector needle, suitable for GC-MS analyses of small specimens, is described together with its application in a study on ants."}],"publist_id":"2232","extern":"1","year":"2002","_id":"3920","acknowledgement":"We thank Giancarlo Bucelli and Gloriano Moneti (Centro Interdipartimentale\r\ndi Spettrometria di Massa, Università di Firenze) for their help. Funding was\r\nprovided by the MURST “60%” and Italian CNR “40%” funds, as well as through\r\nthe research network “Social evolution” of the Universities of Aarhus, Firenze,\r\nKeele, Sheffield, Uppsala, Würzburg and the ETH of Zürich financed by the\r\nEuropean commission via the Training and Mobility of Researchers (TMR)\r\nprogramme. ","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","title":"A method for analysing small-size specimens in GC-MS","status":"public","intvolume":" 4","publisher":"Elsevier","author":[{"full_name":"Turillazzi, Stefano","last_name":"Turillazzi","first_name":"Stefano"},{"full_name":"Sledge, Matthew","last_name":"Sledge","first_name":"Matthew"},{"last_name":"Cremer","first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"},{"first_name":"Jürgen","last_name":"Heinze","full_name":"Heinze, Jürgen"}],"date_created":"2018-12-11T12:05:54Z","date_updated":"2023-06-13T12:57:06Z","volume":4,"oa_version":"None"},{"oa":1,"external_id":{"pmid":["12235359"]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/"}],"quality_controlled":"1","doi":"10.1073/pnas.192233099","language":[{"iso":"eng"}],"month":"09","publication_identifier":{"issn":["0027-8424"]},"year":"2002","acknowledgement":"We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis (to H.M.).","pmid":1,"publication_status":"published","publisher":"National Academy of Sciences","author":[{"last_name":"Bartos","first_name":"Marlene","full_name":"Bartos, Marlene"},{"last_name":"Vida","first_name":"Imre","full_name":"Vida, Imre"},{"first_name":"Michael","last_name":"Frotscher","full_name":"Frotscher, Michael"},{"full_name":"Meyer, Axel","last_name":"Meyer","first_name":"Axel"},{"full_name":"Monyer, Hannah","first_name":"Hannah","last_name":"Monyer"},{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M"}],"date_updated":"2023-07-10T13:35:18Z","date_created":"2018-12-11T12:05:14Z","volume":99,"publist_id":"2409","extern":"1","publication":"PNAS","citation":{"chicago":"Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer, Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS. National Academy of Sciences, 2002. https://doi.org/10.1073/pnas.192233099.","short":"M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas, PNAS 99 (2002) 13222–13227.","mla":"Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS, vol. 99, no. 20, National Academy of Sciences, 2002, pp. 13222–27, doi:10.1073/pnas.192233099.","ieee":"M. Bartos et al., “Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks,” PNAS, vol. 99, no. 20. National Academy of Sciences, pp. 13222–13227, 2002.","apa":"Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., & Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.192233099","ista":"Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 99(20), 13222–13227.","ama":"Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS. 2002;99(20):13222-13227. doi:10.1073/pnas.192233099"},"article_type":"original","page":"13222 - 13227","date_published":"2002-09-16T00:00:00Z","scopus_import":"1","day":"16","article_processing_charge":"No","_id":"3800","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks","status":"public","intvolume":" 99","oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"Networks of GABAergic interneurons are of critical importance for the generation of gamma frequency oscillations in the brain. To examine the underlying synaptic mechanisms, we made paired recordings from "basket cells" (BCs) in different subfields of hippocampal slices, using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling."}],"issue":"20"}]