---
_id: '3622'
abstract:
- lang: eng
text: The extent of genetic variation in fitness and its components and genetic
variation's dependence on environmental conditions remain key issues in evolutionary
biology. We present measurements of genetic variation in preadult viability in
a laboratory-adapted population of Drosophila melanogaster, made at four different
densities. By crossing flies heterozygous for a wild-type chromosome and one of
two different balancers (TM1, TM2), we measure both heterozygous (TM1/+, TM2/+)
and homozygous (+/+) viability relative to a standard genotype (TM1/TM2). Forty
wild-type chromosomes were tested, of which 10 were chosen to be homozygous viable.
The mean numbers produced varied significantly between chromosome lines, with
an estimated between-line variance in loge numbers of 0.013. Relative viabilities
also varied significantly across chromosome lines, with a variance in loge homozygous
viability of 1.76 and of loge heterozygous viability of 0.165. The between-line
variance for numbers emerging increased with density, from 0.009 at lowest density
to 0.079 at highest. The genetic variance in relative viability increases with
density, but not significantly. Overall, the effects of different chromosomes
on relative viability were remarkably consistent across densities and across the
two heterozygous genotypes (TM1, TM2). The 10 lines that carried homozygous viable
wild-type chromosomes produced significantly more adults than the 30 lethal lines
at low density and significantly fewer adults at the highest density. Similarly,
there was a positive correlation between heterozygous viability and mean numbers
at low density, but a negative correlation at high density.
acknowledgement: We thank SERC and BBSRC for financial support and R.Miah, G. Geddes,
and E. Garcia for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Gardner, Michael
last_name: Gardner
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Linda
full_name: Patridge, Linda
last_name: Patridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Gardner M, Fowler K, Patridge L, Barton NH. Genetic variation for preadult
viability in Drosophila melanogaster. Evolution. 2001;55(8):1609-1620.
doi:10.1111/j.0014-3820.2001.tb00680.x
apa: Gardner, M., Fowler, K., Patridge, L., & Barton, N. H. (2001). Genetic
variation for preadult viability in Drosophila melanogaster. Evolution.
Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x
chicago: Gardner, Michael, Kevin Fowler, Linda Patridge, and Nicholas H Barton.
“Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution.
Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x.
ieee: M. Gardner, K. Fowler, L. Patridge, and N. H. Barton, “Genetic variation for
preadult viability in Drosophila melanogaster,” Evolution, vol. 55, no.
8. Wiley-Blackwell, pp. 1609–1620, 2001.
ista: Gardner M, Fowler K, Patridge L, Barton NH. 2001. Genetic variation for preadult
viability in Drosophila melanogaster. Evolution. 55(8), 1609–1620.
mla: Gardner, Michael, et al. “Genetic Variation for Preadult Viability in Drosophila
Melanogaster.” Evolution, vol. 55, no. 8, Wiley-Blackwell, 2001, pp. 1609–20,
doi:10.1111/j.0014-3820.2001.tb00680.x.
short: M. Gardner, K. Fowler, L. Patridge, N.H. Barton, Evolution 55 (2001) 1609–1620.
date_created: 2018-12-11T12:04:18Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-11T13:43:30Z
day: '01'
doi: 10.1111/j.0014-3820.2001.tb00680.x
extern: '1'
external_id:
pmid:
- '11580020'
intvolume: ' 55'
issue: '8'
language:
- iso: eng
main_file_link:
- url: http://www.jstor.org/stable/2680379
month: '08'
oa_version: None
page: 1609 - 1620
pmid: 1
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2761'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic variation for preadult viability in Drosophila melanogaster
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2001'
...
---
_id: '3596'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Mendel and mathematics. Trends in Genetics. 2001;17:420-420.
doi:10.1016/S0168-9525(01)02315-0
apa: Barton, N. H. (2001). Mendel and mathematics. Trends in Genetics. Elsevier.
https://doi.org/10.1016/S0168-9525(01)02315-0
chicago: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics.
Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02315-0.
ieee: N. H. Barton, “Mendel and mathematics,” Trends in Genetics, vol. 17.
Elsevier, pp. 420–420, 2001.
ista: Barton NH. 2001. Mendel and mathematics. Trends in Genetics. 17, 420–420.
mla: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics, vol.
17, Elsevier, 2001, pp. 420–420, doi:10.1016/S0168-9525(01)02315-0.
short: N.H. Barton, Trends in Genetics 17 (2001) 420–420.
date_created: 2018-12-11T12:04:09Z
date_published: 2001-07-01T00:00:00Z
date_updated: 2023-05-11T13:50:32Z
day: '01'
doi: 10.1016/S0168-9525(01)02315-0
extern: '1'
intvolume: ' 17'
language:
- iso: eng
month: '07'
oa_version: None
page: 420 - 420
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9479
publication_status: published
publisher: Elsevier
publist_id: '2787'
quality_controlled: '1'
status: public
title: Mendel and mathematics
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '3546'
abstract:
- lang: eng
text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated
in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a
significantly stronger relationship among local (<140 <mu>m) pyramidal
neurons compared with distant (>300 mum) neurons during non-theta-associated
immobility and sleep but not during theta-associated running and walking. In contrast,
cross-correlation between local pyramidal cell-interneuron pairs was significantly
stronger than between distant pairs during theta oscillations but were similar
during non-theta-associated behaviors. We suggest that network state-dependent
functional clustering of neuronal activity emerges because of the differential
contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals
during theta and non-theta behaviors.
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001
apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G.
(2001). Behavior-dependent states of the hippocampal network affect functional
clustering of neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001
chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and
György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional
Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience,
2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001.
ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent
states of the hippocampal network affect functional clustering of neurons,” Journal
of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001.
ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 21(10).
mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network
Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol.
21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001.
short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal
of Neuroscience 21 (2001).
date_created: 2018-12-11T12:03:54Z
date_published: 2001-05-15T00:00:00Z
date_updated: 2023-05-12T09:47:39Z
day: '15'
doi: 10.1523/JNEUROSCI.21-10-j0003.2001
extern: '1'
external_id:
pmid:
- '11319243'
intvolume: ' 21'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/11319243/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2839'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavior-dependent states of the hippocampal network affect functional clustering
of neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3540'
abstract:
- lang: eng
text: What determines the firing rate of cortical neurons in the absence of external
sensory input or motor behavior, such as during sleep? Hero we report that, in
a familiar environment, the discharge frequency of simultaneously recorded individual
CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated
across sleep-wake-steep sequences. However, both measures were affected when new
sets of neurons were activated in a novel environment. Nevertheless, the grand
mean firing rate of the whole pyramidal cell population remained constant across
behavioral states and testing conditions. The findings suggest that long-term
firing patterns of single cells can be modified by experience. We hypothesize
that increased firing rates of recently used neurons are associated with a concomitant
decrease in the discharge activity of the remaining population, leaving the mean
excitability of the hippocampal network unaltered.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.),
and the Uehara Memorial Foundation (H.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of
hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398
apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G.
(2001). Firing rates of hippocampal neurons are preserved during subsequent sleep
episodes and modified by novel awake experience. PNAS. National Academy
of Sciences. https://doi.org/10.1073/pnas.161274398
chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent
Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National
Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398.
ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing
rates of hippocampal neurons are preserved during subsequent sleep episodes and
modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy
of Sciences, pp. 9386–9390, 2001.
ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates
of hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 98(16), 9386–9390.
mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during
Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS,
vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398.
short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98
(2001) 9386–9390.
date_created: 2018-12-11T12:03:52Z
date_published: 2001-07-31T00:00:00Z
date_updated: 2023-05-12T10:07:41Z
day: '31'
doi: 10.1073/pnas.161274398
extern: '1'
external_id:
pmid:
- '11470910'
intvolume: ' 98'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/
month: '07'
oa: 1
oa_version: Published Version
page: 9386 - 9390
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2846'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes
and modified by novel awake experience
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '3494'
abstract:
- lang: eng
text: 'Mutual synaptic interactions between GABAergic interneurons are thought to
be of critical importance for the generation of network oscillations and for temporal
encoding of information in the hippocampus. However, the functional properties
of synaptic transmission between hippocampal interneurons are largely unknown.
We have made paired recordings from basket cells (BCs) in the dentate gyrus of
rat hippocampal slices, followed by correlated light and electron microscopical
analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the
soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2
msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression
(PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression
during repetitive stimulation. Detailed passive cable model simulations based
on somatodendritic morphology and localization of synaptic contacts further indicated
that the conductance change at the postsynaptic site was even faster, decaying
with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed
that the decay time course of IPSCs at BC–BC synapses was approximately twofold
faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable.
To examine the consequences of the fast postsynaptic conductance change for the
generation of oscillatory activity, we developed a computational model of an interneuron
network. The model showed robust oscillations at frequencies >60 Hz if the
excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron
synapses may promote the generation of high-frequency oscillations observed in
the dentate gyrusin vivo. '
acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft
(SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B).
We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading
this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction
and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory
synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001
apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001).
Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001
chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M
Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron
Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001.
ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling
at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of
Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001.
ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at
inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
21(8), 2687–2698.
mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate
Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society
for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001.
short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience
21 (2001) 2687–2698.
date_created: 2018-12-11T12:03:37Z
date_published: 2001-04-15T00:00:00Z
date_updated: 2023-05-15T13:47:04Z
day: '15'
doi: 10.1523/JNEUROSCI.21-08-02687.2001
extern: '1'
external_id:
pmid:
- '11306622'
intvolume: ' 21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/
month: '04'
oa: 1
oa_version: Published Version
page: 2687 - 2698
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2893'
quality_controlled: '1'
status: public
title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...