--- _id: '3622' abstract: - lang: eng text: The extent of genetic variation in fitness and its components and genetic variation's dependence on environmental conditions remain key issues in evolutionary biology. We present measurements of genetic variation in preadult viability in a laboratory-adapted population of Drosophila melanogaster, made at four different densities. By crossing flies heterozygous for a wild-type chromosome and one of two different balancers (TM1, TM2), we measure both heterozygous (TM1/+, TM2/+) and homozygous (+/+) viability relative to a standard genotype (TM1/TM2). Forty wild-type chromosomes were tested, of which 10 were chosen to be homozygous viable. The mean numbers produced varied significantly between chromosome lines, with an estimated between-line variance in loge numbers of 0.013. Relative viabilities also varied significantly across chromosome lines, with a variance in loge homozygous viability of 1.76 and of loge heterozygous viability of 0.165. The between-line variance for numbers emerging increased with density, from 0.009 at lowest density to 0.079 at highest. The genetic variance in relative viability increases with density, but not significantly. Overall, the effects of different chromosomes on relative viability were remarkably consistent across densities and across the two heterozygous genotypes (TM1, TM2). The 10 lines that carried homozygous viable wild-type chromosomes produced significantly more adults than the 30 lethal lines at low density and significantly fewer adults at the highest density. Similarly, there was a positive correlation between heterozygous viability and mean numbers at low density, but a negative correlation at high density. acknowledgement: We thank SERC and BBSRC for financial support and R.Miah, G. Geddes, and E. Garcia for technical assistance. article_processing_charge: No article_type: original author: - first_name: Michael full_name: Gardner, Michael last_name: Gardner - first_name: Kevin full_name: Fowler, Kevin last_name: Fowler - first_name: Linda full_name: Patridge, Linda last_name: Patridge - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Gardner M, Fowler K, Patridge L, Barton NH. Genetic variation for preadult viability in Drosophila melanogaster. Evolution. 2001;55(8):1609-1620. doi:10.1111/j.0014-3820.2001.tb00680.x apa: Gardner, M., Fowler, K., Patridge, L., & Barton, N. H. (2001). Genetic variation for preadult viability in Drosophila melanogaster. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x chicago: Gardner, Michael, Kevin Fowler, Linda Patridge, and Nicholas H Barton. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution. Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x. ieee: M. Gardner, K. Fowler, L. Patridge, and N. H. Barton, “Genetic variation for preadult viability in Drosophila melanogaster,” Evolution, vol. 55, no. 8. Wiley-Blackwell, pp. 1609–1620, 2001. ista: Gardner M, Fowler K, Patridge L, Barton NH. 2001. Genetic variation for preadult viability in Drosophila melanogaster. Evolution. 55(8), 1609–1620. mla: Gardner, Michael, et al. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution, vol. 55, no. 8, Wiley-Blackwell, 2001, pp. 1609–20, doi:10.1111/j.0014-3820.2001.tb00680.x. short: M. Gardner, K. Fowler, L. Patridge, N.H. Barton, Evolution 55 (2001) 1609–1620. date_created: 2018-12-11T12:04:18Z date_published: 2001-08-01T00:00:00Z date_updated: 2023-05-11T13:43:30Z day: '01' doi: 10.1111/j.0014-3820.2001.tb00680.x extern: '1' external_id: pmid: - '11580020' intvolume: ' 55' issue: '8' language: - iso: eng main_file_link: - url: http://www.jstor.org/stable/2680379 month: '08' oa_version: None page: 1609 - 1620 pmid: 1 publication: Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '2761' quality_controlled: '1' scopus_import: '1' status: public title: Genetic variation for preadult viability in Drosophila melanogaster type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 55 year: '2001' ... --- _id: '3596' article_processing_charge: No author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. Mendel and mathematics. Trends in Genetics. 2001;17:420-420. doi:10.1016/S0168-9525(01)02315-0 apa: Barton, N. H. (2001). Mendel and mathematics. Trends in Genetics. Elsevier. https://doi.org/10.1016/S0168-9525(01)02315-0 chicago: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics. Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02315-0. ieee: N. H. Barton, “Mendel and mathematics,” Trends in Genetics, vol. 17. Elsevier, pp. 420–420, 2001. ista: Barton NH. 2001. Mendel and mathematics. Trends in Genetics. 17, 420–420. mla: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics, vol. 17, Elsevier, 2001, pp. 420–420, doi:10.1016/S0168-9525(01)02315-0. short: N.H. Barton, Trends in Genetics 17 (2001) 420–420. date_created: 2018-12-11T12:04:09Z date_published: 2001-07-01T00:00:00Z date_updated: 2023-05-11T13:50:32Z day: '01' doi: 10.1016/S0168-9525(01)02315-0 extern: '1' intvolume: ' 17' language: - iso: eng month: '07' oa_version: None page: 420 - 420 publication: Trends in Genetics publication_identifier: issn: - 0168-9479 publication_status: published publisher: Elsevier publist_id: '2787' quality_controlled: '1' status: public title: Mendel and mathematics type: review user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 17 year: '2001' ... --- _id: '3546' abstract: - lang: eng text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 <mu>m) pyramidal neurons compared with distant (>300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors. article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001 apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G. (2001). Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001 chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001. ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent states of the hippocampal network affect functional clustering of neurons,” Journal of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001. ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 21(10). mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol. 21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001. short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal of Neuroscience 21 (2001). date_created: 2018-12-11T12:03:54Z date_published: 2001-05-15T00:00:00Z date_updated: 2023-05-12T09:47:39Z day: '15' doi: 10.1523/JNEUROSCI.21-10-j0003.2001 extern: '1' external_id: pmid: - '11319243' intvolume: ' 21' issue: '10' language: - iso: eng main_file_link: - open_access: '1' url: https://pubmed.ncbi.nlm.nih.gov/11319243/ month: '05' oa: 1 oa_version: Published Version pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2839' quality_controlled: '1' scopus_import: '1' status: public title: Behavior-dependent states of the hippocampal network affect functional clustering of neurons type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ... --- _id: '3540' abstract: - lang: eng text: What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Hero we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-steep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered. acknowledgement: This work was supported by National Institutes of Health Grants NS34994 and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.), and the Uehara Memorial Foundation (H.H.). article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398 apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (2001). Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.161274398 chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398. ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy of Sciences, pp. 9386–9390, 2001. ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 98(16), 9386–9390. mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS, vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398. short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98 (2001) 9386–9390. date_created: 2018-12-11T12:03:52Z date_published: 2001-07-31T00:00:00Z date_updated: 2023-05-12T10:07:41Z day: '31' doi: 10.1073/pnas.161274398 extern: '1' external_id: pmid: - '11470910' intvolume: ' 98' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/ month: '07' oa: 1 oa_version: Published Version page: 9386 - 9390 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '2846' quality_controlled: '1' scopus_import: '1' status: public title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 98 year: '2001' ... --- _id: '3494' abstract: - lang: eng text: 'Mutual synaptic interactions between GABAergic interneurons are thought to be of critical importance for the generation of network oscillations and for temporal encoding of information in the hippocampus. However, the functional properties of synaptic transmission between hippocampal interneurons are largely unknown. We have made paired recordings from basket cells (BCs) in the dentate gyrus of rat hippocampal slices, followed by correlated light and electron microscopical analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2 msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression (PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression during repetitive stimulation. Detailed passive cable model simulations based on somatodendritic morphology and localization of synaptic contacts further indicated that the conductance change at the postsynaptic site was even faster, decaying with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed that the decay time course of IPSCs at BC–BC synapses was approximately twofold faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable. To examine the consequences of the fast postsynaptic conductance change for the generation of oscillatory activity, we developed a computational model of an interneuron network. The model showed robust oscillations at frequencies >60 Hz if the excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron synapses may promote the generation of high-frequency oscillations observed in the dentate gyrusin vivo. ' acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B). We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical assistance. article_processing_charge: No article_type: original author: - first_name: Marlene full_name: Bartos, Marlene last_name: Bartos - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001 apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001). Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001 chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001. ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001. ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 21(8), 2687–2698. mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001. short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience 21 (2001) 2687–2698. date_created: 2018-12-11T12:03:37Z date_published: 2001-04-15T00:00:00Z date_updated: 2023-05-15T13:47:04Z day: '15' doi: 10.1523/JNEUROSCI.21-08-02687.2001 extern: '1' external_id: pmid: - '11306622' intvolume: ' 21' issue: '8' language: - iso: eng main_file_link: - open_access: '1' url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/ month: '04' oa: 1 oa_version: Published Version page: 2687 - 2698 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2893' quality_controlled: '1' status: public title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ...