--- _id: '4477' abstract: - lang: eng text: The assume-guarantee paradigm is a powerful divide-and-conquer mechanism for decomposing a verification task about a system into subtasks about the individual components of the system. The key to assume-guarantee reasoning is to consider each component not in isolation, but in conjunction with assumptions about the context of the component. Assume-guarantee principles are known for purely concurrent contexts, which constrain the input data of a component, as well as for purely sequential contexts, which constrain the entry configurations of a component. We present a model for hierarchical system design which permits the arbitrary nesting of parallel as well as serial composition, and which supports an assume-guarantee principle for mixed parallel-serial contexts. Our model also supports both discrete and continuous processes, and is therefore well-suited for the modeling and analysis of embedded software systems which interact with real-world environments. Using an example of two cooperating robots, we show refinement between a high-level model which specifies continuous timing constraints and an implementation which relies on discrete sampling. acknowledgement: Support for this research was provided in part by the AFOSR MURI grant F49620- 00-1-0327, and the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT-660, the NSF ITR grant CCR-0085949. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Marius full_name: Minea, Marius last_name: Minea - first_name: Vinayak full_name: Prabhu, Vinayak last_name: Prabhu citation: ama: 'Henzinger TA, Minea M, Prabhu V. Assume-guarantee reasoning for hierarchical hybrid systems. In: Proceedings of the 4th International Workshop on Hybrid Systems. Vol 2034. Springer; 2001:275-290. doi:10.1007/3-540-45351-2_24' apa: 'Henzinger, T. A., Minea, M., & Prabhu, V. (2001). Assume-guarantee reasoning for hierarchical hybrid systems. In Proceedings of the 4th International Workshop on Hybrid Systems (Vol. 2034, pp. 275–290). Rome, Italy: Springer. https://doi.org/10.1007/3-540-45351-2_24' chicago: Henzinger, Thomas A, Marius Minea, and Vinayak Prabhu. “Assume-Guarantee Reasoning for Hierarchical Hybrid Systems.” In Proceedings of the 4th International Workshop on Hybrid Systems, 2034:275–90. Springer, 2001. https://doi.org/10.1007/3-540-45351-2_24. ieee: T. A. Henzinger, M. Minea, and V. Prabhu, “Assume-guarantee reasoning for hierarchical hybrid systems,” in Proceedings of the 4th International Workshop on Hybrid Systems, Rome, Italy, 2001, vol. 2034, pp. 275–290. ista: 'Henzinger TA, Minea M, Prabhu V. 2001. Assume-guarantee reasoning for hierarchical hybrid systems. Proceedings of the 4th International Workshop on Hybrid Systems. HSCC: Hybrid Systems - Computation and Control, LNCS, vol. 2034, 275–290.' mla: Henzinger, Thomas A., et al. “Assume-Guarantee Reasoning for Hierarchical Hybrid Systems.” Proceedings of the 4th International Workshop on Hybrid Systems, vol. 2034, Springer, 2001, pp. 275–90, doi:10.1007/3-540-45351-2_24. short: T.A. Henzinger, M. Minea, V. Prabhu, in:, Proceedings of the 4th International Workshop on Hybrid Systems, Springer, 2001, pp. 275–290. conference: end_date: 2001-03-30 location: Rome, Italy name: 'HSCC: Hybrid Systems - Computation and Control' start_date: 2001-03-28 date_created: 2018-12-11T12:09:03Z date_published: 2001-03-14T00:00:00Z date_updated: 2023-05-09T14:47:37Z day: '14' doi: 10.1007/3-540-45351-2_24 extern: '1' intvolume: ' 2034' language: - iso: eng month: '03' oa_version: None page: 275 - 290 publication: Proceedings of the 4th International Workshop on Hybrid Systems publication_identifier: isbn: - '9783540418665' publication_status: published publisher: Springer publist_id: '250' quality_controlled: '1' scopus_import: '1' status: public title: Assume-guarantee reasoning for hierarchical hybrid systems type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2034 year: '2001' ... --- _id: '4478' abstract: - lang: eng text: Giotto is a principled, tool-supported design methodology for implementing embedded control systems on platforms of possibly distributed sensors, actuators, CPUs, and networks. Giotto is based on the principle that time-triggered task invocations plus time-triggered mode switches can form the abstract essence of programming real-time control systems. Giotto consists of a programming language with a formal semantics, and a retargetable compiler and runtime library. Giotto supports the automation of control system design by strictly separating platform-independent functionality and timing concerns from platform-dependent scheduling and communication issues. The time-triggered predictability of Giotto makes it particularly suitable for safety-critical applications with hard real-time constraints. We illustrate the platform-independence and time-triggered execution of Giotto by coordinating a heterogeneous flock of Intel x86 robots and Lego Mindstorms robots. acknowledgement: We thank Rupak Majumdar for implementing a prototype Giotto compiler for Lego Mindstorms robots. We thank Dmitry Derevyanko and Winthrop Williams for building our Intel x86 robots. We thank Edward Lee and Xiaojun Liu for help with a Ptolemy II [4] implementation of Giotto. This research was supported in part by the DARPA SEC grant F33615-C-98-3614, the DARPA MoBIES grant F33615- 00-C-1703, the MARCO GSRC grant 98-DT-660, the AFOSR MURI grant F49620-00-1-0327, and the NSF ITR grant CCR-0085949. article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Benjamin full_name: Horowitz, Benjamin last_name: Horowitz - first_name: Christoph full_name: Kirsch, Christoph last_name: Kirsch citation: ama: 'Henzinger TA, Horowitz B, Kirsch C. Embedded control systems development with Giotto. In: Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems. ACM; 2001:64-72. doi:10.1145/384197.384208' apa: 'Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Embedded control systems development with Giotto. In Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems (pp. 64–72). New York, NY, United States: ACM. https://doi.org/10.1145/384197.384208' chicago: Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Embedded Control Systems Development with Giotto.” In Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, 64–72. ACM, 2001. https://doi.org/10.1145/384197.384208. ieee: T. A. Henzinger, B. Horowitz, and C. Kirsch, “Embedded control systems development with Giotto,” in Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems, New York, NY, United States, 2001, pp. 64–72. ista: 'Henzinger TA, Horowitz B, Kirsch C. 2001. Embedded control systems development with Giotto. Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems. LCTES: Languages, Compilers, and Tools for Embedded Systems, 64–72.' mla: Henzinger, Thomas A., et al. “Embedded Control Systems Development with Giotto.” Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, ACM, 2001, pp. 64–72, doi:10.1145/384197.384208. short: T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools for Embedded Systems, ACM, 2001, pp. 64–72. conference: location: New York, NY, United States name: 'LCTES: Languages, Compilers, and Tools for Embedded Systems' date_created: 2018-12-11T12:09:03Z date_published: 2001-06-01T00:00:00Z date_updated: 2023-05-10T09:37:20Z day: '01' doi: 10.1145/384197.384208 extern: '1' language: - iso: eng month: '06' oa_version: None page: 64 - 72 publication: Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and tools for embedded systems publication_identifier: isbn: - '9781581134254' publication_status: published publisher: ACM publist_id: '251' quality_controlled: '1' scopus_import: '1' status: public title: Embedded control systems development with Giotto type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2001' ... --- _id: '4479' abstract: - lang: eng text: Giotto provides an abstract programmer’s model for the implementation of embedded control systems with hard real-time constraints. A typical control application consists of periodic software tasks together with a mode switching logic for enabling and disabling tasks. Giotto specifies time-triggered sensor readings, task invocations, and mode switches independent of any implementation platform. Giotto can be annotated with platform constraints such as task-to-host mappings, and task and communication schedules. The annotations are directives for the Giotto compiler, but they do not alter the functionality and timing of a Giotto program. By separating the platform-independent from the platform-dependent concerns, Giotto enables a great deal of flexibility in choosing control platforms as well as a great deal of automation in the validation and synthesis of control software. The time-triggered nature of Giotto achieves timing predictability, which makes Giotto particularly suitable for safety-critical applications. acknowledgement: This research was supported in part by the DARPA SEC grant F33615-C-98-3614 and by the MARCO GSRC grant 98-DT-660. alternative_title: - LNCS article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Benjamin full_name: Horowitz, Benjamin last_name: Horowitz - first_name: Christoph full_name: Kirsch, Christoph last_name: Kirsch citation: ama: 'Henzinger TA, Horowitz B, Kirsch C. Giotto: A time-triggered language for embedded programming. In: Proceedings of the 1st International Workshop on Embedded Software. Vol 2211. ACM; 2001:166-184. doi:10.1007/3-540-45449-7_12' apa: 'Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Giotto: A time-triggered language for embedded programming. In Proceedings of the 1st International Workshop on Embedded Software (Vol. 2211, pp. 166–184). Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7_12' chicago: 'Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Giotto: A Time-Triggered Language for Embedded Programming.” In Proceedings of the 1st International Workshop on Embedded Software, 2211:166–84. ACM, 2001. https://doi.org/10.1007/3-540-45449-7_12.' ieee: 'T. A. Henzinger, B. Horowitz, and C. Kirsch, “Giotto: A time-triggered language for embedded programming,” in Proceedings of the 1st International Workshop on Embedded Software, Tahoe City, CA, USA, 2001, vol. 2211, pp. 166–184.' ista: 'Henzinger TA, Horowitz B, Kirsch C. 2001. Giotto: A time-triggered language for embedded programming. Proceedings of the 1st International Workshop on Embedded Software. EMSOFT: Embedded Software , LNCS, vol. 2211, 166–184.' mla: 'Henzinger, Thomas A., et al. “Giotto: A Time-Triggered Language for Embedded Programming.” Proceedings of the 1st International Workshop on Embedded Software, vol. 2211, ACM, 2001, pp. 166–84, doi:10.1007/3-540-45449-7_12.' short: T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 1st International Workshop on Embedded Software, ACM, 2001, pp. 166–184. conference: end_date: 2001-10-10 location: Tahoe City, CA, USA name: 'EMSOFT: Embedded Software ' start_date: 2001-10-08 date_created: 2018-12-11T12:09:04Z date_published: 2001-09-26T00:00:00Z date_updated: 2023-05-10T09:42:10Z day: '26' doi: 10.1007/3-540-45449-7_12 extern: '1' intvolume: ' 2211' language: - iso: eng month: '09' oa_version: None page: 166 - 184 publication: Proceedings of the 1st International Workshop on Embedded Software publication_identifier: isbn: - '9783540426738' publication_status: published publisher: ACM publist_id: '252' quality_controlled: '1' scopus_import: '1' status: public title: 'Giotto: A time-triggered language for embedded programming' type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2211 year: '2001' ... --- _id: '4475' abstract: - lang: eng text: We provide an overview of the current status of HYTECH, and reflect on some of the lessons learned from our experiences with the tool. HYTECH is a symbolic model checker for mixed discrete-continuous systems that are modeled as automata with piecewise-constant polyhedral differential inclusions. The use of a formal input language and automated procedures for state-space traversal lay the foundation for formally verifying properties of hybrid dynamical systems. We describe some recent experiences analyzing three hybrid systems. We point out the successes and limitations of the tool. The analysis procedure has been extended in a number of ways to address some of the tool's shortcomings. We evaluate these extensions, and conclude with some desiderata for verification tools for hybrid systems. article_processing_charge: No author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000−0002−2985−7724 - first_name: Joerg full_name: Preussig, Joerg last_name: Preussig - first_name: Howard full_name: Wong Toi, Howard last_name: Wong Toi citation: ama: 'Henzinger TA, Preussig J, Wong Toi H. Some lessons from the HYTECH experience. In: Proceedings of the 40th IEEE Conference on Decision and Control. Vol 3. IEEE; 2001:2887-2892. doi:10.1109/.2001.980714' apa: 'Henzinger, T. A., Preussig, J., & Wong Toi, H. (2001). Some lessons from the HYTECH experience. In Proceedings of the 40th IEEE Conference on Decision and Control (Vol. 3, pp. 2887–2892). Orlando, FL, USA: IEEE. https://doi.org/10.1109/.2001.980714' chicago: Henzinger, Thomas A, Joerg Preussig, and Howard Wong Toi. “Some Lessons from the HYTECH Experience.” In Proceedings of the 40th IEEE Conference on Decision and Control, 3:2887–92. IEEE, 2001. https://doi.org/10.1109/.2001.980714. ieee: T. A. Henzinger, J. Preussig, and H. Wong Toi, “Some lessons from the HYTECH experience,” in Proceedings of the 40th IEEE Conference on Decision and Control, Orlando, FL, USA, 2001, vol. 3, pp. 2887–2892. ista: 'Henzinger TA, Preussig J, Wong Toi H. 2001. Some lessons from the HYTECH experience. Proceedings of the 40th IEEE Conference on Decision and Control. CDC: Decision and Control vol. 3, 2887–2892.' mla: Henzinger, Thomas A., et al. “Some Lessons from the HYTECH Experience.” Proceedings of the 40th IEEE Conference on Decision and Control, vol. 3, IEEE, 2001, pp. 2887–92, doi:10.1109/.2001.980714. short: T.A. Henzinger, J. Preussig, H. Wong Toi, in:, Proceedings of the 40th IEEE Conference on Decision and Control, IEEE, 2001, pp. 2887–2892. conference: end_date: 2001-12-07 location: Orlando, FL, USA name: 'CDC: Decision and Control' start_date: 2001-12-04 date_created: 2018-12-11T12:09:02Z date_published: 2001-05-01T00:00:00Z date_updated: 2023-05-10T09:47:20Z day: '01' doi: 10.1109/.2001.980714 extern: '1' intvolume: ' 3' language: - iso: eng month: '05' oa_version: None page: 2887 - 2892 publication: Proceedings of the 40th IEEE Conference on Decision and Control publication_identifier: isbn: - '0780370619' publication_status: published publisher: IEEE publist_id: '253' quality_controlled: '1' scopus_import: '1' status: public title: Some lessons from the HYTECH experience type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 3 year: '2001' ... --- _id: '4449' abstract: - lang: eng text: Embedded software is software that interacts with physical processes. As em- bedded systems increasingly permeate our daily lives on all levels, from micros- copic devices to international networks, the cost-efficient development of reliable embedded software is one of the grand challenges in computer science today. The purpose of the workshop is to bring together researchers in all areas of computer science that are traditionally distinct but relevant to embedded software develop- ment, and to incubate a research community in this way. The workshop aims to cover all aspects of the design and implementation of embedded software, inclu- ding operating systems and middleware, programming languages and compilers, modeling and validation, software engineering and programming methodologies, scheduling and execution time analysis, networking and fault tolerance, as well as application areas, such as embedded control, real-time signal processing, and telecommunications. alternative_title: - LNCS article_processing_charge: No citation: ama: 'Henzinger TA, ed. EMSOFT: Embedded Software. Vol 2211. ACM; 2001. doi:10.1007/3-540-45449-7' apa: 'Henzinger, T. A. (Ed.). (2001). EMSOFT: Embedded Software (Vol. 2211). Presented at the EMSOFT 2001: Embedded Software, Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7' chicago: 'Henzinger, Thomas A, ed. EMSOFT: Embedded Software. Vol. 2211. ACM, 2001. https://doi.org/10.1007/3-540-45449-7.' ieee: 'T. A. Henzinger, Ed., EMSOFT: Embedded Software, vol. 2211. ACM, 2001.' ista: 'Henzinger TA ed. 2001. EMSOFT: Embedded Software, ACM,p.' mla: 'Henzinger, Thomas A., editor. EMSOFT: Embedded Software. Vol. 2211, ACM, 2001, doi:10.1007/3-540-45449-7.' short: 'T.A. Henzinger, ed., EMSOFT: Embedded Software, ACM, 2001.' conference: end_date: 2001-10-10 location: Tahoe City, CA, USA name: 'EMSOFT 2001: Embedded Software' start_date: 2001-10-08 date_created: 2018-12-11T12:08:54Z date_published: 2001-09-26T00:00:00Z date_updated: 2023-05-10T09:53:17Z day: '26' doi: 10.1007/3-540-45449-7 editor: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 extern: '1' intvolume: ' 2211' language: - iso: eng month: '09' oa_version: None publication_identifier: isbn: - '9783540426738' publication_status: published publisher: ACM publist_id: '283' quality_controlled: '1' status: public title: 'EMSOFT: Embedded Software' type: conference_editor user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2211 year: '2001' ... --- _id: '4278' abstract: - lang: eng text: 'The ability of species to migrate that has interested ecologists for many years. Now that so many species and ecosystems face major environmental change, the ability of species to adapt to these changes by dispersing, migrating, or moving between different patches of habitat can be crucial to ensuring their survivial. This book provides a timely and wide-ranging overview of the study of dispersal and incorporates much of the latest research. The causes, mechanisms, and consequences of dispersal at the individual, population, species and community levels are considered. The potential of new techniques and models for studying dispersal, drawn from molecular biology and demography, is also explored. Perspectives and insights are offered from the fields of evolution, conservation biology and genetics. Throughout the book, theoretical approaches are combined with empirical data, and care has been taken to include examples from as wide a range of species as possible. ' article_processing_charge: No author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: 'Barton NH. The evolutionary consequences of gene flow and local adaptation: Future approaches. In: Dispersal. Oxford University Press; 2001.' apa: 'Barton, N. H. (2001). The evolutionary consequences of gene flow and local adaptation: Future approaches. In Dispersal. Oxford University Press.' chicago: 'Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local Adaptation: Future Approaches.” In Dispersal. Oxford University Press, 2001.' ieee: 'N. H. Barton, “The evolutionary consequences of gene flow and local adaptation: Future approaches,” in Dispersal, Oxford University Press, 2001.' ista: 'Barton NH. 2001.The evolutionary consequences of gene flow and local adaptation: Future approaches. In: Dispersal. .' mla: 'Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local Adaptation: Future Approaches.” Dispersal, Oxford University Press, 2001.' short: N.H. Barton, in:, Dispersal, Oxford University Press, 2001. date_created: 2018-12-11T12:08:00Z date_published: 2001-04-01T00:00:00Z date_updated: 2023-05-10T09:57:10Z day: '01' extern: '1' language: - iso: eng main_file_link: - url: https://www.nhbs.com/dispersal-book month: '04' oa_version: None publication: Dispersal publication_identifier: isbn: - '9780198506591' publication_status: published publisher: Oxford University Press publist_id: '1812' quality_controlled: '1' status: public title: 'The evolutionary consequences of gene flow and local adaptation: Future approaches' type: book_chapter user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2001' ... --- _id: '4200' abstract: - lang: eng text: Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mb1(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl(-/-) embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3 beta can restore eye and telencephalic fates to mb1(-/-) embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories. acknowledgement: "We thank many colleagues who provided reagents that enabled us to test axin1 and several other genes as candidates for the mbl mutation. In particular, we are indebted to Masahiko Hibi, Ken Irvine, Antonio Jacinto, Yun-Jin Jiang, Julian Lewis, and Tom Vogt for help and advice. We thank Ajay Chitnis and Dana Zivkovic for providing information prior to publication. This study was supported primarily by grants from the EMBO and EC to C.P.H., Wellcome Trust and EC to S.W.W., from the MRC to D.S., from Naito to M.T., from the DHGP to G.J.R. and R.G., and from the CRC/ICR to T.D. P.C. was supported by a PhD studentship from Fundação para a Ciência e Tecnologia, Programa PRAXIS XXI. S.W.W. is a Wellcome Trust Senior Research Fellow.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact." article_processing_charge: No article_type: original author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Corinne full_name: Houart, Corinne last_name: Houart - first_name: Masaya full_name: Take Uchi, Masaya last_name: Take Uchi - first_name: Gerd full_name: Rauch, Gerd last_name: Rauch - first_name: Neville full_name: Young, Neville last_name: Young - first_name: Pedro full_name: Coutinho, Pedro last_name: Coutinho - first_name: Ichiro full_name: Masai, Ichiro last_name: Masai - first_name: Luca full_name: Caneparo, Luca last_name: Caneparo - first_name: Miguel full_name: Concha, Miguel last_name: Concha - first_name: Robert full_name: Geisler, Robert last_name: Geisler - first_name: Trevor full_name: Dale, Trevor last_name: Dale - first_name: Stephen full_name: Wilson, Stephen last_name: Wilson - first_name: Derek full_name: Stemple, Derek last_name: Stemple citation: ama: Heisenberg C-PJ, Houart C, Take Uchi M, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 2001;15(11):1427-1434. doi:10.1101/gad.194301 apa: Heisenberg, C.-P. J., Houart, C., Take Uchi, M., Rauch, G., Young, N., Coutinho, P., … Stemple, D. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.194301 chicago: Heisenberg, Carl-Philipp J, Corinne Houart, Masaya Take Uchi, Gerd Rauch, Neville Young, Pedro Coutinho, Ichiro Masai, et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.194301. ieee: C.-P. J. Heisenberg et al., “A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon,” Genes and Development, vol. 15, no. 11. Cold Spring Harbor Laboratory Press, pp. 1427–1434, 2001. ista: Heisenberg C-PJ, Houart C, Take Uchi M, Rauch G, Young N, Coutinho P, Masai I, Caneparo L, Concha M, Geisler R, Dale T, Wilson S, Stemple D. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 15(11), 1427–1434. mla: Heisenberg, Carl-Philipp J., et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development, vol. 15, no. 11, Cold Spring Harbor Laboratory Press, 2001, pp. 1427–34, doi:10.1101/gad.194301. short: C.-P.J. Heisenberg, C. Houart, M. Take Uchi, G. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. Concha, R. Geisler, T. Dale, S. Wilson, D. Stemple, Genes and Development 15 (2001) 1427–1434. date_created: 2018-12-11T12:07:33Z date_published: 2001-06-01T00:00:00Z date_updated: 2023-05-10T12:27:02Z day: '01' doi: 10.1101/gad.194301 extern: '1' external_id: pmid: - '11390362' intvolume: ' 15' issue: '11' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312705/ month: '06' oa: 1 oa_version: Published Version page: 1427 - 1434 pmid: 1 publication: Genes and Development publication_identifier: issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory Press publist_id: '1916' quality_controlled: '1' status: public title: A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '2001' ... --- _id: '4266' abstract: - lang: eng text: Hybridization may influence evolution in a variety of ways. If hybrids are less fit, the geographical range of ecologically divergent populations may be limited, and prezygotic reproductive isolation may be reinforced. If some hybrid genotypes are fitter than one or both parents, at least in some environments, then hybridization could make a positive contribution. Single alleles that are at an advantage in the alternative environment and genetic background will introgress readily, although such introgression may be hard to detect. 'Hybrid speciation', in which fit combinations of alleles are established, is more problematic; its likelihood depends on how divergent populations meet, and on the structure of epistasis. These issues are illustrated using Fisher's model of stabilizing selection on multiple traits, under which reproductive isolation evolves as a side-effect of adaptation in allopatry. This confirms a priori arguments that while recombinant hybrids are less fit on average, some gene combinations may be fitter than the parents, even in the parental environment. Fisher's model does predict heterosis in diploid F1s, asymmetric incompatibility in reciprocal backcrosses, and (when dominance is included) Haldane's Rule. However, heterosis arises only when traits are additive, whereas the latter two patterns require dominance. Moreover, because adaptation is via substitutions of small effect, Fisher's model does not generate the strong effects of single chromosome regions often observed in species crosses. acknowledgement: This work was supported by the Darwin Trust of Edinburgh and by grant GR3/11635 from the Natural Environment Research Council. I would like to thank Loren Rieseberg, Allen Orr, Michael Turelli, and an anonymous referee for their helpful comments article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. The role of hybridization in evolution. Molecular Ecology. 2001;10(3):551-568. doi:10.1046/j.1365-294X.2001.01216.x apa: Barton, N. H. (2001). The role of hybridization in evolution. Molecular Ecology. Wiley-Blackwell. https://doi.org/10.1046/j.1365-294X.2001.01216.x chicago: Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular Ecology. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.1365-294X.2001.01216.x. ieee: N. H. Barton, “The role of hybridization in evolution,” Molecular Ecology, vol. 10, no. 3. Wiley-Blackwell, pp. 551–568, 2001. ista: Barton NH. 2001. The role of hybridization in evolution. Molecular Ecology. 10(3), 551–568. mla: Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular Ecology, vol. 10, no. 3, Wiley-Blackwell, 2001, pp. 551–68, doi:10.1046/j.1365-294X.2001.01216.x. short: N.H. Barton, Molecular Ecology 10 (2001) 551–568. date_created: 2018-12-11T12:07:56Z date_published: 2001-03-01T00:00:00Z date_updated: 2023-05-10T11:45:07Z day: '01' doi: 10.1046/j.1365-294X.2001.01216.x extern: '1' external_id: pmid: - '11298968' intvolume: ' 10' issue: '3' language: - iso: eng month: '03' oa_version: None page: 551 - 568 pmid: 1 publication: Molecular Ecology publication_identifier: issn: - 962-1083 publication_status: published publisher: Wiley-Blackwell publist_id: '1824' quality_controlled: '1' scopus_import: '1' status: public title: The role of hybridization in evolution type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 10 year: '2001' ... --- _id: '4265' abstract: - lang: eng text: The reasons that sex and recombination are so widespread remain elusive. One popular hypothesis is that sex and recombination promote adaptation to a changing environment. The strongest evidence that increased recombination may evolve because recombination promotes adaptation comes from artificially selected populations. Recombination rates have been found to increase as a correlated response to selection on traits unrelated to recombination in several artificial selection experiments and in a comparison of domesticated and nondomesticated mammals. There are, however, several alternative explanations for the increase in recombination in such populations, including two different evolutionary explanations. The first is that the form of selection is epistatic, generating linkage disequilibria among selected loci, which can indirectly favor modifier alleles that increase recombination. The second is that random genetic drift in selected populations tends to generate disequilibria such that beneficial alleles are often found in different individuals; modifier alleles that increase recombination can bring together such favorable alleles and thus may be found in individuals with greater fitness. In this paper, we compare the evolutionary forces acting on recombination in finite populations subject to strong selection, To our surprise, we found that drift accounted for the majority of selection for increased recombination observed in simulations of small to moderately large populations, suggesting that, unless selected populations are large, epistasis plays a secondary role in the evolution of recombination. acknowledgement: "We are grateful to P. Awadalla, T. Lenormand, A. Peters, S. West, M. Whitlock, and two anonymous reviewers for helpful comments on the manuscript. Funding was provided by the Natural Sciences and Engineering Research Council\r\n(Canada) to SPO, the Centre National de la Recherche Scientifique (France) to SPO, the Darwin Trust of Edinburgh to\r\nNHB, and the BBSRC (U.K.) to NHB. " article_processing_charge: No article_type: original author: - first_name: Sarah full_name: Otto, Sarah last_name: Otto - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Otto S, Barton NH. Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. 2001;55(10):1921-1931. doi:10.1111/j.0014-3820.2001.tb01310.x apa: Otto, S., & Barton, N. H. (2001). Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb01310.x chicago: Otto, Sarah, and Nicholas H Barton. “Selection for Recombination in Small Populations.” Evolution; International Journal of Organic Evolution. Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb01310.x. ieee: S. Otto and N. H. Barton, “Selection for recombination in small populations,” Evolution; International Journal of Organic Evolution, vol. 55, no. 10. Wiley-Blackwell, pp. 1921–1931, 2001. ista: Otto S, Barton NH. 2001. Selection for recombination in small populations. Evolution; International Journal of Organic Evolution. 55(10), 1921–1931. mla: Otto, Sarah, and Nicholas H. Barton. “Selection for Recombination in Small Populations.” Evolution; International Journal of Organic Evolution, vol. 55, no. 10, Wiley-Blackwell, 2001, pp. 1921–31, doi:10.1111/j.0014-3820.2001.tb01310.x. short: S. Otto, N.H. Barton, Evolution; International Journal of Organic Evolution 55 (2001) 1921–1931. date_created: 2018-12-11T12:07:56Z date_published: 2001-10-01T00:00:00Z date_updated: 2023-05-10T12:12:32Z day: '01' doi: 10.1111/j.0014-3820.2001.tb01310.x extern: '1' external_id: pmid: - '11761054' intvolume: ' 55' issue: '10' language: - iso: eng month: '10' oa_version: None page: 1921 - 1931 pmid: 1 publication: Evolution; International Journal of Organic Evolution publication_identifier: issn: - 0014-3820 publication_status: published publisher: Wiley-Blackwell publist_id: '1827' quality_controlled: '1' scopus_import: '1' status: public title: Selection for recombination in small populations type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 55 year: '2001' ... --- _id: '4229' abstract: - lang: eng text: Bacteriophage of the family Leviviridae have played an important role in molecular biology where representative species, such as Qβ and MS2, have been studied as model systems for replication, translation, and the role of secondary structure in gene regulation. Using nucleotide sequences from the coat and replicase genes we present the first statistical estimate of phylogeny for the family Leviviridae using maximum-likelihood and Bayesian estimation. Our analyses reveal that the coliphage species are a monophyletic group consisting of two clades representing the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from its common ancestor with the coliphage prior to the ancient split between these genera and their subsequent diversification. Differences in genome size, gene composition, and gene expression are shown with a high probability to have changed along the lineage leading to the Allolevivirus through gene expansion. The change in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes that led to their current genome organization and gene expression. acknowledgement: "We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves, and Bret Larget for helpful comments and\r\nsuggestions. This work was supported by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to J.P.H." article_processing_charge: No article_type: original author: - first_name: Jonathan P full_name: Bollback, Jonathan P id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87 last_name: Bollback orcid: 0000-0002-4624-4612 - first_name: John full_name: Huelsenbeck, John last_name: Huelsenbeck citation: ama: Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 2001;52(2):117-128. doi:10.1007/s002390010140 apa: Bollback, J. P., & Huelsenbeck, J. (2001). Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. Springer. https://doi.org/10.1007/s002390010140 chicago: Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” Journal of Molecular Evolution. Springer, 2001. https://doi.org/10.1007/s002390010140. ieee: J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae),” Journal of Molecular Evolution, vol. 52, no. 2. Springer, pp. 117–128, 2001. ista: Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 52(2), 117–128. mla: Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” Journal of Molecular Evolution, vol. 52, no. 2, Springer, 2001, pp. 117–28, doi:10.1007/s002390010140. short: J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128. date_created: 2018-12-11T12:07:43Z date_published: 2001-02-01T00:00:00Z date_updated: 2023-05-10T12:23:49Z day: '01' doi: 10.1007/s002390010140 extern: '1' external_id: pmid: - '11231891' intvolume: ' 52' issue: '2' language: - iso: eng month: '02' oa_version: None page: 117 - 128 pmid: 1 publication: Journal of Molecular Evolution publication_identifier: issn: - 0022-2844 publication_status: published publisher: Springer publist_id: '1886' quality_controlled: '1' status: public title: Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae) type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 52 year: '2001' ... --- _id: '4264' abstract: - lang: eng text: The study of speciation has become one of the most active areas of evolutionary biology, and substantial progress has been made in documenting and understanding phenomena ranging from sympatric speciation and reinforcement to the evolutionary genetics of postzygotic isolation. This progress has been driven largely by empirical results, and most useful theoretical work has concentrated on making sense of empirical patterns. Given the complexity of speciation, mathematical theory is subordinate to verbal theory and generalizations about data. Nevertheless, mathematical theory can provide a useful classification of verbal theories; can help determine the biological plausibility of verbal theories; can determine whether alternative mechanisms of speciation are consistent with empirical patterns; and can occasionally provide predictions that go beyond empirical generalizations. We discuss recent examples of progress in each of these areas. acknowledgement: 'We thank D. Bolnick, B. Fitzpatrick, S. Gavrilets, R. Haygood, C.D. Jones, M. Kirkpatrick, A. Kondrashov, J.B. Mullet, S.V. Nuzhdin, H.A. Orr, T.D. Price, T. Prout, D.W. Schemske, D. Schluter, M.R. Servedio and P.S. Ward for discussion and comments. Some of these reviewers disagree with our conclusions. This work was supported by US National Science Foundation grants DEB 9527808 and DEB 0089716 to MT, grants from the Darwin Trust of Edinburgh and the Biotechnology and Biological Sciences Research Council (GRJ/76057, GR/H/09928) to NHB, and National Institutes of Health grant R01 GM58260 to JAC. ' article_processing_charge: No article_type: original author: - first_name: Michael full_name: Turelli, Michael last_name: Turelli - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Jerry full_name: Coyne, Jerry last_name: Coyne citation: ama: Turelli M, Barton NH, Coyne J. Theory and speciation. Trends in Ecology and Evolution. 2001;16(7):330-343. doi:10.1016/S0169-5347(01)02177-2 apa: Turelli, M., Barton, N. H., & Coyne, J. (2001). Theory and speciation. Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/S0169-5347(01)02177-2 chicago: Turelli, Michael, Nicholas H Barton, and Jerry Coyne. “Theory and Speciation.” Trends in Ecology and Evolution. Cell Press, 2001. https://doi.org/10.1016/S0169-5347(01)02177-2. ieee: M. Turelli, N. H. Barton, and J. Coyne, “Theory and speciation,” Trends in Ecology and Evolution, vol. 16, no. 7. Cell Press, pp. 330–343, 2001. ista: Turelli M, Barton NH, Coyne J. 2001. Theory and speciation. Trends in Ecology and Evolution. 16(7), 330–343. mla: Turelli, Michael, et al. “Theory and Speciation.” Trends in Ecology and Evolution, vol. 16, no. 7, Cell Press, 2001, pp. 330–43, doi:10.1016/S0169-5347(01)02177-2. short: M. Turelli, N.H. Barton, J. Coyne, Trends in Ecology and Evolution 16 (2001) 330–343. date_created: 2018-12-11T12:07:55Z date_published: 2001-07-01T00:00:00Z date_updated: 2023-05-10T12:16:55Z day: '01' doi: 10.1016/S0169-5347(01)02177-2 extern: '1' external_id: pmid: - '11403865' intvolume: ' 16' issue: '7' language: - iso: eng month: '07' oa_version: None page: 330 - 343 pmid: 1 publication: Trends in Ecology and Evolution publication_identifier: issn: - 0169-5347 publication_status: published publisher: Cell Press publist_id: '1828' quality_controlled: '1' status: public title: Theory and speciation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 16 year: '2001' ... --- _id: '4267' abstract: - lang: eng text: The flow of genes from the dense and well-adapted centre of a species' distribution interferes with adaptation to marginal environments, and may sharply limit a species' range. Deterministic models of a linear habitat suggest that populations could in principle adapt to very steep environmental gradients, by increasing their genetic variability. However, random fluctuations in sparse populations reduce this variance, and may be crucial in limiting the species' range. article_processing_charge: No author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: 'Barton NH. Adaptation at the edge of a species’ range. In: Integrating Ecology and Evolution in a Spatial Context. Cambridge University Press; 2001:365-392.' apa: Barton, N. H. (2001). Adaptation at the edge of a species’ range. In Integrating ecology and evolution in a spatial context (pp. 365–392). Cambridge University Press. chicago: Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” In Integrating Ecology and Evolution in a Spatial Context, 365–92. Cambridge University Press, 2001. ieee: N. H. Barton, “Adaptation at the edge of a species’ range,” in Integrating ecology and evolution in a spatial context, Cambridge University Press, 2001, pp. 365–392. ista: 'Barton NH. 2001.Adaptation at the edge of a species’ range. In: Integrating ecology and evolution in a spatial context. , 365–392.' mla: Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–92. short: N.H. Barton, in:, Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–392. date_created: 2018-12-11T12:07:57Z date_published: 2001-08-01T00:00:00Z date_updated: 2023-05-10T11:59:06Z day: '01' extern: '1' language: - iso: eng main_file_link: - url: https://www.cambridge.org/us/academic/subjects/life-sciences/ecology-and-conservation/integrating-ecology-and-evolution-spatial-context-14th-special-symposium-british-ecological-society?format=HB&isbn=9780521840002 month: '08' oa_version: None page: 365 - 392 publication: Integrating ecology and evolution in a spatial context publication_identifier: isbn: - '9780521840002' publication_status: published publisher: Cambridge University Press publist_id: '1825' quality_controlled: '1' status: public title: Adaptation at the edge of a species' range type: book_chapter user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2001' ... --- _id: '4002' abstract: - lang: eng text: Shape deformation refers to the continuous change of one geometric object to another. We develop a software tool for planning, analyzing and visualizing deformations between two shapes in R-2. The deformation is generated automatically without any user intervention or specification of feature correspondences. A unique property of the tool is the explicit availability of a two-dimensional shape space, which can be used for designing the deformation either automatically by following constraints and objectives or manually by drawing deformation paths. acknowledgement: NSF under grants CCR-96-19542 and CCR-97-12088. article_processing_charge: No article_type: original author: - first_name: Siu full_name: Cheng, Siu last_name: Cheng - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Ping full_name: Fu, Ping last_name: Fu - first_name: Ka full_name: Lam, Ka last_name: Lam citation: ama: 'Cheng S, Edelsbrunner H, Fu P, Lam K. Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. 2001;19(2-3):205-218. doi:10.1016/S0925-7721(01)00020-7' apa: 'Cheng, S., Edelsbrunner, H., Fu, P., & Lam, K. (2001). Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(01)00020-7' chicago: 'Cheng, Siu, Herbert Edelsbrunner, Ping Fu, and Ka Lam. “Design and Analysis of Planar Shape Deformation.” Computational Geometry: Theory and Applications. Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00020-7.' ieee: 'S. Cheng, H. Edelsbrunner, P. Fu, and K. Lam, “Design and analysis of planar shape deformation,” Computational Geometry: Theory and Applications, vol. 19, no. 2–3. Elsevier, pp. 205–218, 2001.' ista: 'Cheng S, Edelsbrunner H, Fu P, Lam K. 2001. Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. 19(2–3), 205–218.' mla: 'Cheng, Siu, et al. “Design and Analysis of Planar Shape Deformation.” Computational Geometry: Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 205–18, doi:10.1016/S0925-7721(01)00020-7.' short: 'S. Cheng, H. Edelsbrunner, P. Fu, K. Lam, Computational Geometry: Theory and Applications 19 (2001) 205–218.' date_created: 2018-12-11T12:06:22Z date_published: 2001-07-01T00:00:00Z date_updated: 2023-05-10T14:21:31Z day: '01' doi: 10.1016/S0925-7721(01)00020-7 extern: '1' intvolume: ' 19' issue: 2-3 language: - iso: eng month: '07' oa_version: None page: 205 - 218 publication: 'Computational Geometry: Theory and Applications' publication_identifier: issn: - 0925-7721 publication_status: published publisher: Elsevier publist_id: '2124' quality_controlled: '1' scopus_import: '1' status: public title: Design and analysis of planar shape deformation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '2001' ... --- _id: '4001' abstract: - lang: eng text: 'The construction of shape spaces is studied from a mathematical and a computational viewpoint. A program is outlined reducing the problem to four tasks: the representation of geometry, the canonical deformation of geometry, the measuring of distance in shape space, and the selection of base shapes. The technical part of this paper focuses on the second task: the specification of a deformation mixing two or more shapes in continuously changing proportions. (C) 2001 Elsevier Science B.V All rights reserved.' acknowledgement: National Science Foundation under grants CCR-96-19542 and CCR-97-12088, and by the Army Research Office under grant DAAG55-98-1-0177. article_processing_charge: No article_type: original author: - first_name: Ho full_name: Cheng, Ho last_name: Cheng - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Ping full_name: Fu, Ping last_name: Fu citation: ama: 'Cheng H, Edelsbrunner H, Fu P. Shape space from deformation. Computational Geometry: Theory and Applications. 2001;19(2-3):191-204. doi:10.1016/S0925-7721(01)00021-9' apa: 'Cheng, H., Edelsbrunner, H., & Fu, P. (2001). Shape space from deformation. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(01)00021-9' chicago: 'Cheng, Ho, Herbert Edelsbrunner, and Ping Fu. “Shape Space from Deformation.” Computational Geometry: Theory and Applications. Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00021-9.' ieee: 'H. Cheng, H. Edelsbrunner, and P. Fu, “Shape space from deformation,” Computational Geometry: Theory and Applications, vol. 19, no. 2–3. Elsevier, pp. 191–204, 2001.' ista: 'Cheng H, Edelsbrunner H, Fu P. 2001. Shape space from deformation. Computational Geometry: Theory and Applications. 19(2–3), 191–204.' mla: 'Cheng, Ho, et al. “Shape Space from Deformation.” Computational Geometry: Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 191–204, doi:10.1016/S0925-7721(01)00021-9.' short: 'H. Cheng, H. Edelsbrunner, P. Fu, Computational Geometry: Theory and Applications 19 (2001) 191–204.' date_created: 2018-12-11T12:06:22Z date_published: 2001-07-01T00:00:00Z date_updated: 2023-05-10T12:57:14Z day: '01' doi: 10.1016/S0925-7721(01)00021-9 extern: '1' intvolume: ' 19' issue: 2-3 language: - iso: eng month: '07' oa_version: None page: 191 - 204 publication: 'Computational Geometry: Theory and Applications' publication_identifier: issn: - 0925-7721 publication_status: published publisher: Elsevier publist_id: '2123' quality_controlled: '1' scopus_import: '1' status: public title: Shape space from deformation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 19 year: '2001' ... --- _id: '4005' abstract: - lang: eng text: This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R-3. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface. article_processing_charge: No author: - first_name: Ho full_name: Cheng, Ho last_name: Cheng - first_name: Tamal full_name: Dey, Tamal last_name: Dey - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: John full_name: Sullivan, John last_name: Sullivan citation: ama: 'Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. In: Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms. SIAM; 2001:47-56.' apa: 'Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin triangulation. In Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms (pp. 47–56). Washington, DC, USA : SIAM.' chicago: Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” In Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, 47–56. SIAM, 2001. ieee: H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” in Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms, Washington, DC, USA , 2001, pp. 47–56. ista: 'Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 47–56.' mla: Cheng, Ho, et al. “Dynamic Skin Triangulation.” Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56. short: H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, in:, Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56. conference: end_date: 2001-01-09 location: 'Washington, DC, USA ' name: 'SODA: Symposium on Discrete Algorithms' start_date: 2001-01-07 date_created: 2018-12-11T12:06:23Z date_published: 2001-01-09T00:00:00Z date_updated: 2023-05-10T12:35:44Z day: '09' extern: '1' language: - iso: eng main_file_link: - url: https://dl.acm.org/doi/10.5555/365411.365418 month: '01' oa_version: None page: 47 - 56 publication: Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms publication_identifier: isbn: - '9780898714906' publication_status: published publisher: SIAM publist_id: '2120' quality_controlled: '1' status: public title: Dynamic skin triangulation type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 year: '2001' ... --- _id: '4007' abstract: - lang: eng text: 'This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R 3 . The surface is the envelope of an infinite family of spheres defined and controlled by a finite collection of weighted points. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface. ' acknowledgement: NSF under grant DMS- 98-73945, ARO under grant DAAG55-98-1-0177, NSF under grants CCR-96- 19542 and CCR-97-12088. article_processing_charge: No article_type: original author: - first_name: Ho full_name: Cheng, Ho last_name: Cheng - first_name: Tamal full_name: Dey, Tamal last_name: Dey - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: John full_name: Sullivan, John last_name: Sullivan citation: ama: Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. Discrete & Computational Geometry. 2001;25(4):525-568. doi:10.1007/s00454-001-0007-1 apa: Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin triangulation. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0007-1 chicago: Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” Discrete & Computational Geometry. Springer, 2001. https://doi.org/10.1007/s00454-001-0007-1. ieee: H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” Discrete & Computational Geometry, vol. 25, no. 4. Springer, pp. 525–568, 2001. ista: Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Discrete & Computational Geometry. 25(4), 525–568. mla: Cheng, Ho, et al. “Dynamic Skin Triangulation.” Discrete & Computational Geometry, vol. 25, no. 4, Springer, 2001, pp. 525–68, doi:10.1007/s00454-001-0007-1. short: H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, Discrete & Computational Geometry 25 (2001) 525–568. date_created: 2018-12-11T12:06:24Z date_published: 2001-04-04T00:00:00Z date_updated: 2023-05-10T12:45:59Z day: '04' doi: 10.1007/s00454-001-0007-1 extern: '1' intvolume: ' 25' issue: '4' language: - iso: eng month: '04' oa_version: None page: 525 - 568 publication: Discrete & Computational Geometry publication_identifier: issn: - 0179-5376 publication_status: published publisher: Springer publist_id: '2122' quality_controlled: '1' scopus_import: '1' status: public title: Dynamic skin triangulation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 25 year: '2001' ... --- _id: '4006' abstract: - lang: eng text: The 180 models collected in this paper are produced by sampling and wrapping point sets on tubes. The surfaces are represented as triangulated 2-manifolds and available as st1-files from the author's web site at www.cs.duke.edu/similar toedels. Each tube is obtained by thickening a circle or a smooth torus knot, and for some we use the degrees of freedom in the thickening process to encode meaningful information, such as curvature or torsion. article_processing_charge: No article_type: original author: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Edelsbrunner H. 180 wrapped tubes. Journal of Universal Computer Science. 2001;7(5):379-399. doi:10.3217/jucs-007-05-0379 apa: Edelsbrunner, H. (2001). 180 wrapped tubes. Journal of Universal Computer Science. Springer. https://doi.org/10.3217/jucs-007-05-0379 chicago: Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer Science. Springer, 2001. https://doi.org/10.3217/jucs-007-05-0379. ieee: H. Edelsbrunner, “180 wrapped tubes,” Journal of Universal Computer Science, vol. 7, no. 5. Springer, pp. 379–399, 2001. ista: Edelsbrunner H. 2001. 180 wrapped tubes. Journal of Universal Computer Science. 7(5), 379–399. mla: Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer Science, vol. 7, no. 5, Springer, 2001, pp. 379–99, doi:10.3217/jucs-007-05-0379. short: H. Edelsbrunner, Journal of Universal Computer Science 7 (2001) 379–399. date_created: 2018-12-11T12:06:24Z date_published: 2001-05-28T00:00:00Z date_updated: 2023-05-10T12:39:54Z day: '28' doi: 10.3217/jucs-007-05-0379 extern: '1' intvolume: ' 7' issue: '5' language: - iso: eng month: '05' oa_version: None page: 379 - 399 publication: Journal of Universal Computer Science publication_identifier: issn: - 0948-695X publication_status: published publisher: Springer publist_id: '2121' quality_controlled: '1' status: public title: 180 wrapped tubes type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 7 year: '2001' ... --- _id: '3928' abstract: - lang: eng text: Regulated adhesion of leukocytes to the extracellular matrix is essential for transmigration of blood vessels and subsequent migration into the stroma of inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)- and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion to and migration on extracellular matrix molecules of the endothelial cell basement membrane and subjacent interstitial matrix. Mouse wild type and beta(2)-integrin null PMN and the progranulocytic cell line 32DC13 were employed in in vitro adhesion and migration assays using extracellular matrix molecules expressed at sites of extravasation in vivo, in particular the endothelial cell laminins 8 and 10. Wild type and beta(2)-integrin null PMN showed the same pattern of ECM binding, indicating that beta(2)-integrins do not mediate specific adhesion of PMN to the extracellular matrix molecules tested; binding was observed to the interstitial matrix molecules, fibronectin and vitronectin, via integrins alpha(5)beta(1) and alpha(v)beta(3), respectively; to laminin 10 via alpha(6)beta(1); but not to laminins 1, 2, and 8, collagen type I and IV, perlecan, or tenascin-C. PMN binding to laminins 1, 2, and 8 could not be induced despite surface expression of functionally active integrin alpha(6)beta(1), a major laminin receptor, demonstrating that expression of alpha(6)beta(1) alone is insufficient for ligand binding and suggesting the involvement of accessory factors. Nevertheless, laminins 1, 8, and 10 supported PMN migration, indicating that differential cellular signaling via laminins is independent of the extent of adhesion. The data demonstrate that adhesive and nonadhesive interactions with components of the endothelial cell basement membrane and subjacent interstitium play decisive roles in controlling PMN movement into sites of inflammation and illustrate that beta(2)-integrins are not essential for such interactions. acknowledgement: We thank Dr. T. Winkler for carrying out flow cytometry analysis, Dr. Simon Goodman for providing cyclic RGD peptides and helpful discussions, and Stefanie Karosi and Thomas Samson for critical review of the manuscript. This work would not have been possible without the expert technical assistance of Friederike Pausch. article_processing_charge: No article_type: original author: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Olaf full_name: Wendler, Olaf last_name: Wendler - first_name: Karin full_name: Scharffetter Kochanek, Karin last_name: Scharffetter Kochanek - first_name: Lydia full_name: Sorokin, Lydia last_name: Sorokin citation: ama: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 2001;276(22):18878-18887. doi:10.1074/jbc.M010898200 apa: Sixt, M. K., Hallmann, R., Wendler, O., Scharffetter Kochanek, K., & Sorokin, L. (2001). Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M010898200 chicago: Sixt, Michael K, Rupert Hallmann, Olaf Wendler, Karin Scharffetter Kochanek, and Lydia Sorokin. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2001. https://doi.org/10.1074/jbc.M010898200. ieee: M. K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, and L. Sorokin, “Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation,” Journal of Biological Chemistry, vol. 276, no. 22. American Society for Biochemistry and Molecular Biology, pp. 18878–18887, 2001. ista: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. 2001. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 276(22), 18878–18887. mla: Sixt, Michael K., et al. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry, vol. 276, no. 22, American Society for Biochemistry and Molecular Biology, 2001, pp. 18878–87, doi:10.1074/jbc.M010898200. short: M.K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, L. Sorokin, Journal of Biological Chemistry 276 (2001) 18878–18887. date_created: 2018-12-11T12:05:56Z date_published: 2001-06-01T00:00:00Z date_updated: 2023-05-11T12:54:06Z day: '01' doi: 10.1074/jbc.M010898200 extern: '1' external_id: pmid: - '11278780' intvolume: ' 276' issue: '22' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S0021925819670134?via%3Dihub month: '06' oa: 1 oa_version: Published Version page: 18878 - 18887 pmid: 1 publication: Journal of Biological Chemistry publication_identifier: issn: - 0021-9258 publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '2199' quality_controlled: '1' scopus_import: '1' status: public title: Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 276 year: '2001' ... --- _id: '3927' abstract: - lang: eng text: TNF-alpha has been clearly identified as central mediator of T cell activation-induced acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We show in this report that the hepatic TNFRs are not transcriptionally regulated, but are regulated by receptor shedding. TNF directly mediates hepatocellular death by activation of TNFR1 but also induces the expression of inflammatory proteins, such as cytokines and adhesion molecules. Here we provide evidence that resistance of TNFR1(-/-) and TNFR2(-/-) mice against Con A hepatitis is not due to an impaired production of the central mediators TNF and IFN-gamma. Con A injection results in a massive induction of ICAM-1, VCAM-1, and E-selectin in the liver. Lack of either one of both TNFRs did not change adhesion molecule expression in the livers of Con A-treated mice, presumably reflecting the fact that other endothelial cell-activating cytokines up-regulated adhesion molecule expression. However, treatment of TNFR1(-/-) and TNFR2(-/-) mice with murine rTNF revealed a predominant role for TNFR1 for the induction of hepatic adhesion molecule expression. Pretreatment with blocking Abs against E- and P-selectin or of ICAM(-/-) mice with anti-VCAM-1 Abs failed to prevent Con A hepatitis, although accumulation of the critical cell population, i.e., CD4(+) T cells was significantly inhibited. Hence, up-regulation of adhesion molecules during acute hepatitis unlikely contributes to organ injury but rather represents a defense mechanism. acknowledgement: We thank Dr. H. Bluethmann (F. Hoffmann-LaRoche AG, Basle, Switzerland) for kindly providing us TNFR knockout mice. We are indebted to Dr. G. R. Adolf (Bender & Co Vienna, Austria) for providing recombinant murine TNF. We are also indebted to Dr. D. Vestweber for providing anti-P-selectin mAb (23). We thank Dr. W. Neuhuber (Institute of Anatomy, University of Erlangen-NÜrnberg, Erlangen, Germany) for experimental support regarding confocal laser scanning microscopy. The perfect technical assistance of Andrea Agli is gratefully acknowledged. article_processing_charge: No article_type: original author: - first_name: Dominik full_name: Wolf, Dominik last_name: Wolf - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Gabriele full_name: Sass, Gabriele last_name: Sass - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Sabine full_name: Küsters, Sabine last_name: Küsters - first_name: Bastian full_name: Fregien, Bastian last_name: Fregien - first_name: Christian full_name: Trautwein, Christian last_name: Trautwein - first_name: Gisa full_name: Tiegs, Gisa last_name: Tiegs citation: ama: Wolf D, Hallmann R, Sass G, et al. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 2001;166(2):1300-1307. doi:10.4049/jimmunol.166.2.1300 apa: Wolf, D., Hallmann, R., Sass, G., Sixt, M. K., Küsters, S., Fregien, B., … Tiegs, G. (2001). TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. American Association of Immunologists. https://doi.org/10.4049/jimmunol.166.2.1300 chicago: Wolf, Dominik, Rupert Hallmann, Gabriele Sass, Michael K Sixt, Sabine Küsters, Bastian Fregien, Christian Trautwein, and Gisa Tiegs. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology. American Association of Immunologists, 2001. https://doi.org/10.4049/jimmunol.166.2.1300. ieee: D. Wolf et al., “TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis,” Journal of Immunology, vol. 166, no. 2. American Association of Immunologists, pp. 1300–1307, 2001. ista: Wolf D, Hallmann R, Sass G, Sixt MK, Küsters S, Fregien B, Trautwein C, Tiegs G. 2001. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 166(2), 1300–1307. mla: Wolf, Dominik, et al. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology, vol. 166, no. 2, American Association of Immunologists, 2001, pp. 1300–07, doi:10.4049/jimmunol.166.2.1300. short: D. Wolf, R. Hallmann, G. Sass, M.K. Sixt, S. Küsters, B. Fregien, C. Trautwein, G. Tiegs, Journal of Immunology 166 (2001) 1300–1307. date_created: 2018-12-11T12:05:56Z date_published: 2001-01-15T00:00:00Z date_updated: 2023-05-11T13:37:29Z day: '15' doi: 10.4049/jimmunol.166.2.1300 extern: '1' external_id: pmid: - '11145713' intvolume: ' 166' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: http://www.jimmunol.org/content/166/2/1300.long month: '01' oa: 1 oa_version: None page: 1300 - 1307 pmid: 1 publication: Journal of Immunology publication_identifier: issn: - 0022-1767 publication_status: published publisher: American Association of Immunologists publist_id: '2200' quality_controlled: '1' status: public title: TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 166 year: '2001' ... --- _id: '3930' abstract: - lang: eng text: 'An active involvement of blood-brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extravasating T lymphocytes during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their expression was influenced by proinflammatory cytokines or angiostatic agents. T cells emigrating into the CNS during EAE encountered two biochemically distinct basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal (containing laminins 1 and 2) basement membranes. However, inflammatory cuffs occurred exclusively around endothelial basement membranes containing laminin 8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and 10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus a high turnover of laminin 8 at these sites, suggested two possible roles for laminin 8 in the endothelial basement membrane: one at the level of the endothelial cells resulting in reduced adhesion and, thereby, increased penetrability of the monolayer; and secondly at the level of the T cells providing direct signals to the transmigrating cells.' acknowledgement: The authors thank Stefanie Karosi for careful and critical reading of the manuscript and Monika Bruckner for expert technical assistance. We are particularly grateful to Winfried Neuhuber for help with confocal microscopy and interpretation of the data. This work was supported by Deutsche Forschungsgemeinschaft grants So285/1-3 and So285/1-4 to L.M. Sorokin. article_processing_charge: No article_type: original author: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Britta full_name: Engelhardt, Britta last_name: Engelhardt - first_name: Friederike full_name: Pausch, Friederike last_name: Pausch - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Olaf full_name: Wendler, Olaf last_name: Wendler - first_name: Lydia full_name: Sorokin, Lydia last_name: Sorokin citation: ama: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 2001;153(5):933-946. doi:10.1083/jcb.153.5.933 apa: Sixt, M. K., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin, L. (2001). Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.153.5.933 chicago: Sixt, Michael K, Britta Engelhardt, Friederike Pausch, Rupert Hallmann, Olaf Wendler, and Lydia Sorokin. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology. Rockefeller University Press, 2001. https://doi.org/10.1083/jcb.153.5.933 . ieee: M. K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, and L. Sorokin, “Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis,” Journal of Cell Biology, vol. 153, no. 5. Rockefeller University Press, pp. 933–946, 2001. ista: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. 2001. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 153(5), 933–946. mla: Sixt, Michael K., et al. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology, vol. 153, no. 5, Rockefeller University Press, 2001, pp. 933–46, doi:10.1083/jcb.153.5.933 . short: M.K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L. Sorokin, Journal of Cell Biology 153 (2001) 933–946. date_created: 2018-12-11T12:05:57Z date_published: 2001-05-21T00:00:00Z date_updated: 2023-05-11T12:19:36Z day: '21' doi: '10.1083/jcb.153.5.933 ' extern: '1' external_id: pmid: - '11381080' intvolume: ' 153' issue: '5' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174323/ month: '05' oa: 1 oa_version: Published Version page: 933 - 946 pmid: 1 publication: Journal of Cell Biology publication_identifier: issn: - 0021-9525 publication_status: published publisher: Rockefeller University Press publist_id: '2198' quality_controlled: '1' scopus_import: '1' status: public title: Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 153 year: '2001' ...