---
_id: '11125'
abstract:
- lang: eng
text: Although nuclear envelope (NE) assembly is known to require the GTPase Ran,
the membrane fusion machinery involved is uncharacterized. NE assembly involves
formation of a reticular network on chromatin, fusion of this network into a closed
NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously implicated
in fusion of Golgi and transitional endoplasmic reticulum (ER) membranes together
with the adaptor p47, has two discrete functions in NE assembly. Formation of
a closed NE requires the p97–Ufd1–Npl4 complex, not previously implicated in membrane
fusion. Subsequent NE growth involves a p97–p47 complex. This study provides the
first insights into the molecular mechanisms and specificity of fusion events
involved in NE formation.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Hemmo H.
full_name: Meyer, Hemmo H.
last_name: Meyer
- first_name: Tobias C.
full_name: Walther, Tobias C.
last_name: Walther
- first_name: Daniel
full_name: Bilbao-Cortes, Daniel
last_name: Bilbao-Cortes
- first_name: Graham
full_name: Warren, Graham
last_name: Warren
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
citation:
ama: Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. Distinct
AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature
Cell Biology. 2001;3(12):1086-1091. doi:10.1038/ncb1201-1086
apa: Hetzer, M., Meyer, H. H., Walther, T. C., Bilbao-Cortes, D., Warren, G., &
Mattaj, I. W. (2001). Distinct AAA-ATPase p97 complexes function in discrete steps
of nuclear assembly. Nature Cell Biology. Springer Nature. https://doi.org/10.1038/ncb1201-1086
chicago: Hetzer, Martin, Hemmo H. Meyer, Tobias C. Walther, Daniel Bilbao-Cortes,
Graham Warren, and Iain W. Mattaj. “Distinct AAA-ATPase P97 Complexes Function
in Discrete Steps of Nuclear Assembly.” Nature Cell Biology. Springer Nature,
2001. https://doi.org/10.1038/ncb1201-1086.
ieee: M. Hetzer, H. H. Meyer, T. C. Walther, D. Bilbao-Cortes, G. Warren, and I.
W. Mattaj, “Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear
assembly,” Nature Cell Biology, vol. 3, no. 12. Springer Nature, pp. 1086–1091,
2001.
ista: Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. 2001.
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly.
Nature Cell Biology. 3(12), 1086–1091.
mla: Hetzer, Martin, et al. “Distinct AAA-ATPase P97 Complexes Function in Discrete
Steps of Nuclear Assembly.” Nature Cell Biology, vol. 3, no. 12, Springer
Nature, 2001, pp. 1086–91, doi:10.1038/ncb1201-1086.
short: M. Hetzer, H.H. Meyer, T.C. Walther, D. Bilbao-Cortes, G. Warren, I.W. Mattaj,
Nature Cell Biology 3 (2001) 1086–1091.
date_created: 2022-04-07T07:57:42Z
date_published: 2001-11-02T00:00:00Z
date_updated: 2022-07-18T08:58:07Z
day: '02'
doi: 10.1038/ncb1201-1086
extern: '1'
external_id:
pmid:
- '11781570'
intvolume: ' 3'
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
month: '11'
oa_version: None
page: 1086-1091
pmid: 1
publication: Nature Cell Biology
publication_identifier:
eissn:
- 1476-4679
issn:
- 1465-7392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 3
year: '2001'
...
---
_id: '11892'
abstract:
- lang: eng
text: "We present the first fully dynamic algorithm for maintaining a minimum spanning
forest in time \U0001D45C(\U0001D45B√) per operation. To be precise, the algorithm
uses O(n1/3 log n) amortized time per update operation. The algorithm is fairly
simple and deterministic. An immediate consequence is the first fully dynamic
deterministic algorithm for maintaining connectivity and bipartiteness in amortized
time O(n1/3 log n) per update, with O(1) worst case time per query."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Valerie
full_name: King, Valerie
last_name: King
citation:
ama: Henzinger MH, King V. Maintaining minimum spanning forests in dynamic graphs.
SIAM Journal on Computing. 2001;31(2):364-374. doi:10.1137/s0097539797327209
apa: Henzinger, M. H., & King, V. (2001). Maintaining minimum spanning forests
in dynamic graphs. SIAM Journal on Computing. Society for Industrial &
Applied Mathematics. https://doi.org/10.1137/s0097539797327209
chicago: Henzinger, Monika H, and Valerie King. “Maintaining Minimum Spanning Forests
in Dynamic Graphs.” SIAM Journal on Computing. Society for Industrial &
Applied Mathematics, 2001. https://doi.org/10.1137/s0097539797327209.
ieee: M. H. Henzinger and V. King, “Maintaining minimum spanning forests in dynamic
graphs,” SIAM Journal on Computing, vol. 31, no. 2. Society for Industrial
& Applied Mathematics, pp. 364–374, 2001.
ista: Henzinger MH, King V. 2001. Maintaining minimum spanning forests in dynamic
graphs. SIAM Journal on Computing. 31(2), 364–374.
mla: Henzinger, Monika H., and Valerie King. “Maintaining Minimum Spanning Forests
in Dynamic Graphs.” SIAM Journal on Computing, vol. 31, no. 2, Society
for Industrial & Applied Mathematics, 2001, pp. 364–74, doi:10.1137/s0097539797327209.
short: M.H. Henzinger, V. King, SIAM Journal on Computing 31 (2001) 364–374.
date_created: 2022-08-17T08:43:43Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-02-17T14:24:55Z
day: '01'
doi: 10.1137/s0097539797327209
extern: '1'
intvolume: ' 31'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 364-374
publication: SIAM Journal on Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maintaining minimum spanning forests in dynamic graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2001'
...
---
_id: '11914'
abstract:
- lang: eng
text: 'Previous studies of the Web graph structure have focused on the graph structure
at the level of individual pages. In actuality the Web is a hierarchically nested
graph, with domains, hosts and Web sites introducing intermediate levels of affiliation
and administrative control. To better understand the growth of the Web we need
to understand its macro-structure, in terms of the linkage between Web sites.
We approximate this by studying the graph of the linkage between hosts on the
Web. This was done based on snapshots of the Web taken by Google in Oct 1999,
Aug 2000 and Jun 2001. The connectivity between hosts is represented by a directed
graph, with hosts as nodes and weighted edges representing the count of hyperlinks
between pages on the corresponding hosts. We demonstrate how such a "hostgraph"
can be used to study connectivity properties of hosts and domains over time, and
discuss a modified "copy model" to explain observed link weight distributions
as a function of subgraph size. We discuss changes in the Web over time in the
size and connectivity of Web sites and country domains. We also describe a data
mining application of the hostgraph: a related host finding algorithm which achieves
a precision of 0.65 at rank 3.'
article_processing_charge: No
author:
- first_name: K.
full_name: Bharat, K.
last_name: Bharat
- first_name: Bay-Wei
full_name: Chang, Bay-Wei
last_name: Chang
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: M.
full_name: Ruhl, M.
last_name: Ruhl
citation:
ama: 'Bharat K, Chang B-W, Henzinger MH, Ruhl M. Who links to whom: Mining linkage
between Web sites. In: 1st IEEE International Conference on Data Mining.
Institute of Electrical and Electronics Engineers; 2001:51-58. doi:10.1109/ICDM.2001.989500'
apa: 'Bharat, K., Chang, B.-W., Henzinger, M. H., & Ruhl, M. (2001). Who links
to whom: Mining linkage between Web sites. In 1st IEEE International Conference
on Data Mining (pp. 51–58). San Jose, CA, United States: Institute of Electrical
and Electronics Engineers. https://doi.org/10.1109/ICDM.2001.989500'
chicago: 'Bharat, K., Bay-Wei Chang, Monika H Henzinger, and M. Ruhl. “Who Links
to Whom: Mining Linkage between Web Sites.” In 1st IEEE International Conference
on Data Mining, 51–58. Institute of Electrical and Electronics Engineers,
2001. https://doi.org/10.1109/ICDM.2001.989500.'
ieee: 'K. Bharat, B.-W. Chang, M. H. Henzinger, and M. Ruhl, “Who links to whom:
Mining linkage between Web sites,” in 1st IEEE International Conference on
Data Mining, San Jose, CA, United States, 2001, pp. 51–58.'
ista: 'Bharat K, Chang B-W, Henzinger MH, Ruhl M. 2001. Who links to whom: Mining
linkage between Web sites. 1st IEEE International Conference on Data Mining. ICMD:
International Conference on Data Mining, 51–58.'
mla: 'Bharat, K., et al. “Who Links to Whom: Mining Linkage between Web Sites.”
1st IEEE International Conference on Data Mining, Institute of Electrical
and Electronics Engineers, 2001, pp. 51–58, doi:10.1109/ICDM.2001.989500.'
short: K. Bharat, B.-W. Chang, M.H. Henzinger, M. Ruhl, in:, 1st IEEE International
Conference on Data Mining, Institute of Electrical and Electronics Engineers,
2001, pp. 51–58.
conference:
end_date: 2001-12-02
location: San Jose, CA, United States
name: 'ICMD: International Conference on Data Mining'
start_date: 2001-11-29
date_created: 2022-08-18T07:12:46Z
date_published: 2001-12-01T00:00:00Z
date_updated: 2023-02-17T09:59:47Z
day: '01'
doi: 10.1109/ICDM.2001.989500
extern: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 51-58
publication: 1st IEEE International Conference on Data Mining
publication_identifier:
isbn:
- 0-7695-1119-8
issn:
- '15504786'
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Who links to whom: Mining linkage between Web sites'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2001'
...
---
_id: '3507'
abstract:
- lang: eng
text: A molecular classification method is based on a space filling description
of a molecule. The three dimensional body corresponding to the space filling molecular
structure is divided into Voronoi regions to provide a basis for efficiently processing
local structural information. A Delaunay triangulation provides a basis for systematically
processing information relating to the Voronoi regions into shape descriptors
in the form of topological elements. Preferably, additional shape and/or property
descriptors are included in the classification method. The classification methods
generally are used to identify similarities between molecules that can be used
as property predictors for a variety of applications. Generally, the property
predictions are the basis for selection of compounds for incorporation into efficacy
evaluations.
applicant:
- Jie Liang, Herbert Edelsbrunner
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Liang J, Edelsbrunner H. Molecular classification for property prediction.
2001.
apa: Liang, J., & Edelsbrunner, H. (2001). Molecular classification for property
prediction.
chicago: Liang, Jie, and Herbert Edelsbrunner. “Molecular Classification for Property
Prediction,” 2001.
ieee: J. Liang and H. Edelsbrunner, “Molecular classification for property prediction.”
2001.
ista: Liang J, Edelsbrunner H. 2001. Molecular classification for property prediction.
mla: Liang, Jie, and Herbert Edelsbrunner. Molecular Classification for Property
Prediction. 2001.
short: J. Liang, H. Edelsbrunner, (2001).
date_created: 2018-12-11T12:03:41Z
date_published: 2001-01-30T00:00:00Z
date_updated: 2022-01-05T15:12:42Z
day: '30'
extern: '1'
ipc: G16C20/70 ; G16B15/00
ipn: US6182016B1
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US6182016B1
month: '01'
oa: 1
oa_version: Published Version
publication_date: 2001-01-30
publist_id: '2880'
status: public
title: Molecular classification for property prediction
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2001'
...
---
_id: '3586'
abstract:
- lang: eng
text: The book combines topics in mathematics (geometry and topology), computer
science (algorithms), and engineering (mesh generation). The original motivation
for these topics was the difficulty faced (both conceptually and in the technical
execution) in any attempt to combine elements of combinatorial and of numerical
algorithms. Mesh generation is a topic where a meaningful combination of these
different approaches to problem solving is inevitable. The book develops methods
from both areas that are amenable to combination, and explains recent breakthrough
solutions to meshing that fit into this category.The book should be an ideal graduate
text for courses on mesh generation. The specific material is selected giving
preference to topics that are elementary, attractive, lend themselves to teaching,
useful, and interesting.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Geometry and Topology for Mesh Generation. Vol 7. Cambridge
University Press; 2001. doi:10.1017/CBO9780511530067
apa: Edelsbrunner, H. (2001). Geometry and Topology for Mesh Generation (Vol.
7). Cambridge University Press. https://doi.org/10.1017/CBO9780511530067
chicago: Edelsbrunner, Herbert. Geometry and Topology for Mesh Generation.
Vol. 7. Cambridge Monographs on Applied and Computational Mathematics. Cambridge
University Press, 2001. https://doi.org/10.1017/CBO9780511530067.
ieee: H. Edelsbrunner, Geometry and Topology for Mesh Generation, vol. 7.
Cambridge University Press, 2001.
ista: Edelsbrunner H. 2001. Geometry and Topology for Mesh Generation, Cambridge
University Press, 190p.
mla: Edelsbrunner, Herbert. Geometry and Topology for Mesh Generation. Vol.
7, Cambridge University Press, 2001, doi:10.1017/CBO9780511530067.
short: H. Edelsbrunner, Geometry and Topology for Mesh Generation, Cambridge University
Press, 2001.
date_created: 2018-12-11T12:04:06Z
date_published: 2001-05-28T00:00:00Z
date_updated: 2021-12-22T08:46:46Z
day: '28'
doi: 10.1017/CBO9780511530067
extern: '1'
intvolume: ' 7'
language:
- iso: eng
month: '05'
oa_version: None
page: '190'
publication_identifier:
eisbn:
- ' 978-0-5115-3006-7'
isbn:
- 0-521-79309-2
publication_status: published
publisher: Cambridge University Press
publist_id: '2798'
quality_controlled: '1'
related_material:
link:
- description: available via catalog IST BookList
relation: other
url: https://koha.app.ist.ac.at/cgi-bin/koha/opac-detail.pl?biblionumber=3508
series_title: Cambridge Monographs on Applied and Computational Mathematics
status: public
title: Geometry and Topology for Mesh Generation
type: book
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 7
year: '2001'
...
---
_id: '3447'
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Pallab
full_name: Dasgupta, Pallab
last_name: Dasgupta
- first_name: Partha
full_name: Chakrabarti, Partha P
last_name: Chakrabarti
citation:
ama: 'Chatterjee K, Dasgupta P, Chakrabarti P. Weighted quantified computation tree
logic. In: Elsevier; 2001.'
apa: 'Chatterjee, K., Dasgupta, P., & Chakrabarti, P. (2001). Weighted quantified
computation tree logic. Presented at the CIT: Conference on Information Technology,
Elsevier.'
chicago: Chatterjee, Krishnendu, Pallab Dasgupta, and Partha Chakrabarti. “Weighted
Quantified Computation Tree Logic.” Elsevier, 2001.
ieee: 'K. Chatterjee, P. Dasgupta, and P. Chakrabarti, “Weighted quantified computation
tree logic,” presented at the CIT: Conference on Information Technology, 2001.'
ista: 'Chatterjee K, Dasgupta P, Chakrabarti P. 2001. Weighted quantified computation
tree logic. CIT: Conference on Information Technology.'
mla: Chatterjee, Krishnendu, et al. Weighted Quantified Computation Tree Logic.
Elsevier, 2001.
short: K. Chatterjee, P. Dasgupta, P. Chakrabarti, in:, Elsevier, 2001.
conference:
name: 'CIT: Conference on Information Technology'
date_created: 2018-12-11T12:03:23Z
date_published: 2001-11-14T00:00:00Z
date_updated: 2021-01-12T07:43:31Z
day: '14'
extern: 1
month: '11'
publication_status: published
publisher: Elsevier
publist_id: '2940'
quality_controlled: 0
status: public
title: Weighted quantified computation tree logic
type: conference
year: '2001'
...
---
_id: '8522'
abstract:
- lang: eng
text: For diffeomorphisms of smooth compact manifolds, we consider the problem of
how fast the number of periodic points with period $n$grows as a function of $n$.
In many familiar cases (e.g., Anosov systems) the growth is exponential, but arbitrarily
fast growth is possible; in fact, the first author has shown that arbitrarily
fast growth is topologically (Baire) generic for $C^2$ or smoother diffeomorphisms.
In the present work we show that, by contrast, for a measure-theoretic notion
of genericity we call ``prevalence'', the growth is not much faster than exponential.
Specifically, we show that for each $\delta > 0$, there is a prevalent set of
( $C^{1+\rho}$ or smoother) diffeomorphisms for which the number of period $n$
points is bounded above by $\operatorname{exp}(C n^{1+\delta})$ for some $C$ independent
of $n$. We also obtain a related bound on the decay of the hyperbolicity of the
periodic points as a function of $n$. The contrast between topologically generic
and measure-theoretically generic behavior for the growth of the number of periodic
points and the decay of their hyperbolicity shows this to be a subtle and complex
phenomenon, reminiscent of KAM theory.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Brian R.
full_name: Hunt, Brian R.
last_name: Hunt
citation:
ama: Kaloshin V, Hunt BR. A stretched exponential bound on the rate of growth of
the number of periodic points for prevalent diffeomorphisms I. Electronic Research
Announcements of the American Mathematical Society. 2001;7(4):17-27. doi:10.1090/s1079-6762-01-00090-7
apa: Kaloshin, V., & Hunt, B. R. (2001). A stretched exponential bound on the
rate of growth of the number of periodic points for prevalent diffeomorphisms
I. Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/s1079-6762-01-00090-7
chicago: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the
Rate of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms
I.” Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society, 2001. https://doi.org/10.1090/s1079-6762-01-00090-7.
ieee: V. Kaloshin and B. R. Hunt, “A stretched exponential bound on the rate of
growth of the number of periodic points for prevalent diffeomorphisms I,” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 4.
American Mathematical Society, pp. 17–27, 2001.
ista: Kaloshin V, Hunt BR. 2001. A stretched exponential bound on the rate of growth
of the number of periodic points for prevalent diffeomorphisms I. Electronic Research
Announcements of the American Mathematical Society. 7(4), 17–27.
mla: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the Rate
of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms I.” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 4,
American Mathematical Society, 2001, pp. 17–27, doi:10.1090/s1079-6762-01-00090-7.
short: V. Kaloshin, B.R. Hunt, Electronic Research Announcements of the American
Mathematical Society 7 (2001) 17–27.
date_created: 2020-09-18T10:49:56Z
date_published: 2001-04-18T00:00:00Z
date_updated: 2021-01-12T08:19:51Z
day: '18'
doi: 10.1090/s1079-6762-01-00090-7
extern: '1'
intvolume: ' 7'
issue: '4'
keyword:
- General Mathematics
language:
- iso: eng
month: '04'
oa_version: None
page: 17-27
publication: Electronic Research Announcements of the American Mathematical Society
publication_identifier:
issn:
- 1079-6762
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: A stretched exponential bound on the rate of growth of the number of periodic
points for prevalent diffeomorphisms I
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2001'
...
---
_id: '8521'
abstract:
- lang: eng
text: We continue the previous article's discussion of bounds, for prevalent diffeomorphisms
of smooth compact manifolds, on the growth of the number of periodic points and
the decay of their hyperbolicity as a function of their period $n$. In that article
we reduced the main results to a problem, for certain families of diffeomorphisms,
of bounding the measure of parameter values for which the diffeomorphism has (for
a given period $n$) an almost periodic point that is almost nonhyperbolic. We
also formulated our results for $1$-dimensional endomorphisms on a compact interval.
In this article we describe some of the main techniques involved and outline the
rest of the proof. To simplify notation, we concentrate primarily on the $1$-dimensional
case.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Brian R.
full_name: Hunt, Brian R.
last_name: Hunt
citation:
ama: Kaloshin V, Hunt BR. A stretched exponential bound on the rate of growth of
the number of periodic points for prevalent diffeomorphisms II. Electronic
Research Announcements of the American Mathematical Society. 2001;7(5):28-36.
doi:10.1090/s1079-6762-01-00091-9
apa: Kaloshin, V., & Hunt, B. R. (2001). A stretched exponential bound on the
rate of growth of the number of periodic points for prevalent diffeomorphisms
II. Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/s1079-6762-01-00091-9
chicago: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the
Rate of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms
II.” Electronic Research Announcements of the American Mathematical Society.
American Mathematical Society, 2001. https://doi.org/10.1090/s1079-6762-01-00091-9.
ieee: V. Kaloshin and B. R. Hunt, “A stretched exponential bound on the rate of
growth of the number of periodic points for prevalent diffeomorphisms II,” Electronic
Research Announcements of the American Mathematical Society, vol. 7, no. 5.
American Mathematical Society, pp. 28–36, 2001.
ista: Kaloshin V, Hunt BR. 2001. A stretched exponential bound on the rate of growth
of the number of periodic points for prevalent diffeomorphisms II. Electronic
Research Announcements of the American Mathematical Society. 7(5), 28–36.
mla: Kaloshin, Vadim, and Brian R. Hunt. “A Stretched Exponential Bound on the Rate
of Growth of the Number of Periodic Points for Prevalent Diffeomorphisms II.”
Electronic Research Announcements of the American Mathematical Society,
vol. 7, no. 5, American Mathematical Society, 2001, pp. 28–36, doi:10.1090/s1079-6762-01-00091-9.
short: V. Kaloshin, B.R. Hunt, Electronic Research Announcements of the American
Mathematical Society 7 (2001) 28–36.
date_created: 2020-09-18T10:49:43Z
date_published: 2001-04-24T00:00:00Z
date_updated: 2021-01-12T08:19:51Z
day: '24'
doi: 10.1090/s1079-6762-01-00091-9
extern: '1'
intvolume: ' 7'
issue: '5'
keyword:
- General Mathematics
language:
- iso: eng
month: '04'
oa_version: None
page: 28-36
publication: Electronic Research Announcements of the American Mathematical Society
publication_identifier:
issn:
- 1079-6762
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: A stretched exponential bound on the rate of growth of the number of periodic
points for prevalent diffeomorphisms II
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2001'
...
---
_id: '8524'
abstract:
- lang: eng
text: 'A number α∈R is diophantine if it is not well approximable by rationals,
i.e. for some C,ε>0 and any relatively prime p,q∈Z we have |αq−p|>Cq−1−ε. It is
well-known and is easy to prove that almost every α in R is diophantine. In this
paper we address a noncommutative version of the diophantine properties. Consider
a pair A,B∈SO(3) and for each n∈Z+ take all possible words in A, A -1, B, and
B - 1 of length n, i.e. for a multiindex I=(i1,i1,…,im,jm) define |I|=∑mk=1(|ik|+|jk|)=n
and \( W_n(A,B ) = \{W_{\cal I}(A,B) = A^{i_1} B^{j_1} \dots A^{i_m} B^{j_m}\}_{|{\cal
I|}=n \).¶Gamburd—Jakobson—Sarnak [GJS] raised the problem: prove that for Haar
almost every pair A,B∈SO(3) the closest distance of words of length n to the identity,
i.e. sA,B(n)=min|I|=n∥WI(A,B)−E∥, is bounded from below by an exponential function
in n. This is the analog of the diophantine property for elements of SO(3). In
this paper we prove that s A,B (n) is bounded from below by an exponential function
in n 2. We also exhibit obstructions to a “simple” proof of the exponential estimate
in n.'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: I.
full_name: Rodnianski, I.
last_name: Rodnianski
citation:
ama: Kaloshin V, Rodnianski I. Diophantine properties of elements of SO(3). Geometric
And Functional Analysis. 2001;11(5):953-970. doi:10.1007/s00039-001-8222-8
apa: Kaloshin, V., & Rodnianski, I. (2001). Diophantine properties of elements
of SO(3). Geometric And Functional Analysis. Springer Nature. https://doi.org/10.1007/s00039-001-8222-8
chicago: Kaloshin, Vadim, and I. Rodnianski. “Diophantine Properties of Elements
of SO(3).” Geometric And Functional Analysis. Springer Nature, 2001. https://doi.org/10.1007/s00039-001-8222-8.
ieee: V. Kaloshin and I. Rodnianski, “Diophantine properties of elements of SO(3),”
Geometric And Functional Analysis, vol. 11, no. 5. Springer Nature, pp.
953–970, 2001.
ista: Kaloshin V, Rodnianski I. 2001. Diophantine properties of elements of SO(3).
Geometric And Functional Analysis. 11(5), 953–970.
mla: Kaloshin, Vadim, and I. Rodnianski. “Diophantine Properties of Elements of
SO(3).” Geometric And Functional Analysis, vol. 11, no. 5, Springer Nature,
2001, pp. 953–70, doi:10.1007/s00039-001-8222-8.
short: V. Kaloshin, I. Rodnianski, Geometric And Functional Analysis 11 (2001) 953–970.
date_created: 2020-09-18T10:50:11Z
date_published: 2001-12-01T00:00:00Z
date_updated: 2021-01-12T08:19:52Z
day: '01'
doi: 10.1007/s00039-001-8222-8
extern: '1'
intvolume: ' 11'
issue: '5'
language:
- iso: eng
month: '12'
oa_version: None
page: 953-970
publication: Geometric And Functional Analysis
publication_identifier:
issn:
- 1016-443X
- 1420-8970
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Diophantine properties of elements of SO(3)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2001'
...
---
_id: '9444'
abstract:
- lang: eng
text: Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent
alleles) are associated with dense hypermethylation at noncanonical cytosines
(CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors
of a hypermethylated clark kent mutant identified nine loss-of-function alleles
of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3
mutants display a wild-type morphology but exhibit decreased CpXpG methylation
of the SUP gene and of other sequences throughout the genome. They also show reactivated
expression of endogenous retrotransposon sequences. These results show that a
non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
article_processing_charge: No
article_type: original
author:
- first_name: A. M.
full_name: Lindroth, A. M.
last_name: Lindroth
- first_name: Xiaofeng
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: James P.
full_name: Jackson, James P.
last_name: Jackson
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Claire M.
full_name: McCallum, Claire M.
last_name: McCallum
- first_name: Steven
full_name: Henikoff, Steven
last_name: Henikoff
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for
maintenance of CpXpG methylation. Science. 2001;292(5524):2077-2080. doi:10.1126/science.1059745
apa: Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff,
S., & Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance
of CpXpG methylation. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1059745
chicago: Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire
M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3
for Maintenance of CpXpG Methylation.” Science. American Association for
the Advancement of Science, 2001. https://doi.org/10.1126/science.1059745.
ieee: A. M. Lindroth et al., “Requirement of CHROMOMETHYLASE3 for maintenance
of CpXpG methylation,” Science, vol. 292, no. 5524. American Association
for the Advancement of Science, pp. 2077–2080, 2001.
ista: Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen
SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation.
Science. 292(5524), 2077–2080.
mla: Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of
CpXpG Methylation.” Science, vol. 292, no. 5524, American Association for
the Advancement of Science, 2001, pp. 2077–80, doi:10.1126/science.1059745.
short: A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff,
S.E. Jacobsen, Science 292 (2001) 2077–2080.
date_created: 2021-06-02T13:35:16Z
date_published: 2001-06-15T00:00:00Z
date_updated: 2021-12-14T08:40:32Z
day: '15'
department:
- _id: DaZi
doi: 10.1126/science.1059745
extern: '1'
external_id:
pmid:
- '11349138'
intvolume: ' 292'
issue: '5524'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '06'
oa_version: None
page: 2077-2080
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 292
year: '2001'
...
---
_id: '4634'
abstract:
- lang: eng
text: "A controller is an environment for a system that achieves a particular control
objective by providing inputs to the system without constraining the choices of
the system. For synchronous systems, where system and controller make simultaneous
and interdependent choices, the notion that a controller must not constrain the
choices of the system can be formalized by type systems for composability. In
a previous paper, we solved the control problem for static and dynamic types:
a static type is a dependency relation between inputs and outputs, and composition
is well-typed if it does not introduce cyclic dependencies; a dynamic type is
a set of static types, one for each state. Static and dynamic types, however,
cannot capture many important digital circuits, such as gated clocks, bidirectional
buses, and random-access memory. We therefore introduce more general type systems,
so-called dependent and bidirectional types, for modeling these situations, and
we solve the corresponding control problems.\r\nIn a system with a dependent type,
the dependencies between inputs and outputs are determined gradually through a
game of the system against the controller. In a system with a bidirectional type,
also the distinction between inputs and outputs is resolved dynamically by such
a game. The game proceeds in several rounds. In each round the system and the
controller choose to update some variables dependent on variables that have already
been updated. The solution of the control problem for dependent and bidirectional
types is based on algorithms for solving these games."
acknowledgement: This research was supported in part by the SRC contract 99-TJ-683.003,
the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT-660, the AFOSR
MURI grant F49620-00-1-0327, and the NSF Theory grant CCR-9988172.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
citation:
ama: 'De Alfaro L, Henzinger TA, Mang F. The control of synchronous systems, Part
II. In: Proceedings of the 12th International Conference on on Concurrency
Theory. Vol 2154. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2001:566-581.
doi:10.1007/3-540-44685-0_38'
apa: 'De Alfaro, L., Henzinger, T. A., & Mang, F. (2001). The control of synchronous
systems, Part II. In Proceedings of the 12th International Conference on on
Concurrency Theory (Vol. 2154, pp. 566–581). Aalborg, Denmark: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-44685-0_38'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Freddy Mang. “The Control of Synchronous
Systems, Part II.” In Proceedings of the 12th International Conference on on
Concurrency Theory, 2154:566–81. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2001. https://doi.org/10.1007/3-540-44685-0_38.
ieee: L. De Alfaro, T. A. Henzinger, and F. Mang, “The control of synchronous systems,
Part II,” in Proceedings of the 12th International Conference on on Concurrency
Theory, Aalborg, Denmark, 2001, vol. 2154, pp. 566–581.
ista: 'De Alfaro L, Henzinger TA, Mang F. 2001. The control of synchronous systems,
Part II. Proceedings of the 12th International Conference on on Concurrency Theory.
CONCUR: Concurrency Theory, LNCS, vol. 2154, 566–581.'
mla: De Alfaro, Luca, et al. “The Control of Synchronous Systems, Part II.” Proceedings
of the 12th International Conference on on Concurrency Theory, vol. 2154,
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2001, pp. 566–81, doi:10.1007/3-540-44685-0_38.
short: L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 12th International
Conference on on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2001, pp. 566–581.
conference:
end_date: 2001-08-25
location: Aalborg, Denmark
name: 'CONCUR: Concurrency Theory'
start_date: 2001-08-20
date_created: 2018-12-11T12:09:52Z
date_published: 2001-08-13T00:00:00Z
date_updated: 2023-05-08T10:20:19Z
day: '13'
doi: 10.1007/3-540-44685-0_38
extern: '1'
intvolume: ' 2154'
language:
- iso: eng
month: '08'
oa_version: None
page: 566 - 581
publication: Proceedings of the 12th International Conference on on Concurrency Theory
publication_identifier:
isbn:
- '9783540424970'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '74'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The control of synchronous systems, Part II
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2154
year: '2001'
...
---
_id: '4633'
abstract:
- lang: eng
text: "A procedure for the analysis of state spaces is called symbolic if it manipulates
not individual states, but sets of states that are represented by constraints.
Such a procedure can be used for the analysis of infinite state spaces, provided
termination is guaranteed. We present symbolic procedures, and corresponding termination
criteria, for the solution of infinite-state games, which occur in the control
and modular verification of infinite-state systems. To characterize the termination
of symbolic procedures for solving infinite-state games, we classify these game
structures into four increasingly restrictive categories:\r\n1 \tClass 1 consists
of infinite-state structures for which all safety and reachability games can be
solved.\r\n2 \tClass 2 consists of infinite-state structures for which all ω-regular
games can be solved.\r\n3 \tClass 3 consists of infinite-state structures for
which all nested positive boolean combinations of ω-regular games can be solved.\r\n4
\ \tClass 4 consists of infinite-state structures for which all nested boolean
combinations of ω-regular games can be solved.\r\nWe give a structural characterization
for each class, using equivalence relations on the state spaces of games which
range from game versions of trace equivalence to a game version of bisimilarity.
We provide infinite-state examples for all four classes of games from control
problems for hybrid systems. We conclude by presenting symbolic algorithms for
the synthesis of winning strategies (“controller synthesis”) for infinitestate
games with arbitrary ω-regular objectives, and prove termination over all class-2
structures. This settles, in particular, the symbolic controller synthesis problem
for rectangular hybrid systems."
acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC grant 98-DT-660, the NSF Theory
grant CCR-9988172, and the NSF ITR grant CCR-0085949.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
citation:
ama: 'De Alfaro L, Henzinger TA, Majumdar R. Symbolic algorithms for infinite-state
games. In: Proceedings of the 12th International Conference on on Concurrency
Theory. Vol 2154. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2001:536-550.
doi:10.1007/3-540-44685-0_36'
apa: 'De Alfaro, L., Henzinger, T. A., & Majumdar, R. (2001). Symbolic algorithms
for infinite-state games. In Proceedings of the 12th International Conference
on on Concurrency Theory (Vol. 2154, pp. 536–550). Aalborg, Denmark: Schloss
Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-44685-0_36'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Ritankar Majumdar. “Symbolic Algorithms
for Infinite-State Games.” In Proceedings of the 12th International Conference
on on Concurrency Theory, 2154:536–50. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2001. https://doi.org/10.1007/3-540-44685-0_36.
ieee: L. De Alfaro, T. A. Henzinger, and R. Majumdar, “Symbolic algorithms for infinite-state
games,” in Proceedings of the 12th International Conference on on Concurrency
Theory, Aalborg, Denmark, 2001, vol. 2154, pp. 536–550.
ista: 'De Alfaro L, Henzinger TA, Majumdar R. 2001. Symbolic algorithms for infinite-state
games. Proceedings of the 12th International Conference on on Concurrency Theory.
CONCUR: Concurrency Theory, LNCS, vol. 2154, 536–550.'
mla: De Alfaro, Luca, et al. “Symbolic Algorithms for Infinite-State Games.” Proceedings
of the 12th International Conference on on Concurrency Theory, vol. 2154,
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2001, pp. 536–50, doi:10.1007/3-540-44685-0_36.
short: L. De Alfaro, T.A. Henzinger, R. Majumdar, in:, Proceedings of the 12th International
Conference on on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2001, pp. 536–550.
conference:
end_date: 2001-08-25
location: Aalborg, Denmark
name: 'CONCUR: Concurrency Theory'
start_date: 2001-08-20
date_created: 2018-12-11T12:09:52Z
date_published: 2001-08-13T00:00:00Z
date_updated: 2023-05-08T09:57:31Z
day: '13'
doi: 10.1007/3-540-44685-0_36
extern: '1'
intvolume: ' 2154'
language:
- iso: eng
month: '08'
oa_version: None
page: 536 - 550
publication: Proceedings of the 12th International Conference on on Concurrency Theory
publication_identifier:
isbn:
- '9783540424970'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '73'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symbolic algorithms for infinite-state games
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2154
year: '2001'
...
---
_id: '4636'
abstract:
- lang: eng
text: 'Abstract. Dynamic programs, or fixpoint iteration schemes, are useful for
solving many problems on state spaces, including model checking on Kripke structures
(“verification”), computing shortest paths on weighted graphs (“optimization”),
computing the value of games played on game graphs (“control”). For Kripke structures,
a rich fixpoint theory is available in the form of the µ-calculus. Yet few connections
have been made between different interpretations of fixpoint algorithms. We study
the question of when a particular fixpoint iteration scheme ϕ for verifying an
ω-regular property Ψ on a Kripke structure can be used also for solving a two-player
game on a game graph with winning objective Ψ. We provide a sufficient and necessary
criterion for the answer to be affirmative in the form of an extremal-model theorem
for games: under a game interpretation, the dynamic program ϕ solves the game
with objective Ψ if and only if both (1) under an existential interpretation on
Kripke structures, ϕ is equivalent to ∃Ψ, and (2) under a universal interpretation
on Kripke structures, ϕ is equivalent to ∀Ψ. In other words, ϕ is correct on all
two-player game graphs iff it is correct on all extremal game graphs, where one
or the other player has no choice of moves. The theorem generalizes to quantitative
interpretations, where it connects two-player games with costs to weighted graphs.
While the standard translations from ω-regular properties to the µ-calculus violate
(1) or (2), we give a translation that satisfies both conditions. Our construction,
therefore, yields fixpoint iteration schemes that can be uniformly applied on
Kripke structures, weighted graphs, game graphs, and game graphs with costs, in
order to meet or optimize a given ω-regular objective.'
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
citation:
ama: 'De Alfaro L, Henzinger TA, Majumdar R. From verification to control: dynamic
programs for omega-regular objectives. In: Proceedings of the 16th Annual IEEE
Symposium on Logic in Computer Science. IEEE; 2001:279-290. doi:10.1109/LICS.2001.932504'
apa: 'De Alfaro, L., Henzinger, T. A., & Majumdar, R. (2001). From verification
to control: dynamic programs for omega-regular objectives. In Proceedings of
the 16th Annual IEEE Symposium on Logic in Computer Science (pp. 279–290).
Boston, MA, USA: IEEE. https://doi.org/10.1109/LICS.2001.932504'
chicago: 'De Alfaro, Luca, Thomas A Henzinger, and Ritankar Majumdar. “From Verification
to Control: Dynamic Programs for Omega-Regular Objectives.” In Proceedings
of the 16th Annual IEEE Symposium on Logic in Computer Science, 279–90. IEEE,
2001. https://doi.org/10.1109/LICS.2001.932504.'
ieee: 'L. De Alfaro, T. A. Henzinger, and R. Majumdar, “From verification to control:
dynamic programs for omega-regular objectives,” in Proceedings of the 16th
Annual IEEE Symposium on Logic in Computer Science, Boston, MA, USA, 2001,
pp. 279–290.'
ista: 'De Alfaro L, Henzinger TA, Majumdar R. 2001. From verification to control:
dynamic programs for omega-regular objectives. Proceedings of the 16th Annual
IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science,
279–290.'
mla: 'De Alfaro, Luca, et al. “From Verification to Control: Dynamic Programs for
Omega-Regular Objectives.” Proceedings of the 16th Annual IEEE Symposium on
Logic in Computer Science, IEEE, 2001, pp. 279–90, doi:10.1109/LICS.2001.932504.'
short: L. De Alfaro, T.A. Henzinger, R. Majumdar, in:, Proceedings of the 16th Annual
IEEE Symposium on Logic in Computer Science, IEEE, 2001, pp. 279–290.
conference:
end_date: 2001-06-19
location: Boston, MA, USA
name: 'LICS: Logic in Computer Science'
start_date: 2001-06-16
date_created: 2018-12-11T12:09:52Z
date_published: 2001-08-07T00:00:00Z
date_updated: 2023-05-08T09:48:06Z
day: '07'
doi: 10.1109/LICS.2001.932504
extern: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 279 - 290
publication: Proceedings of the 16th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
isbn:
- 076951281X
publication_status: published
publisher: IEEE
publist_id: '72'
quality_controlled: '1'
status: public
title: 'From verification to control: dynamic programs for omega-regular objectives'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4635'
abstract:
- lang: eng
text: We show how model checking techniques can be applied to the analysis of connectivity
and cost-of-traversal properties of Web sites.
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
citation:
ama: 'De Alfaro L, Henzinger TA, Mang F. MCWEB: A model-checking tool for web-site
debugging. In: Proceedings of the 10th International Conference on World Wide
Web. ACM; 2001:86-87.'
apa: 'De Alfaro, L., Henzinger, T. A., & Mang, F. (2001). MCWEB: A model-checking
tool for web-site debugging. In Proceedings of the 10th international conference
on World Wide Web (pp. 86–87). Hong Kong, Hong Kong: ACM.'
chicago: 'De Alfaro, Luca, Thomas A Henzinger, and Freddy Mang. “MCWEB: A Model-Checking
Tool for Web-Site Debugging.” In Proceedings of the 10th International Conference
on World Wide Web, 86–87. ACM, 2001.'
ieee: 'L. De Alfaro, T. A. Henzinger, and F. Mang, “MCWEB: A model-checking tool
for web-site debugging,” in Proceedings of the 10th international conference
on World Wide Web, Hong Kong, Hong Kong, 2001, pp. 86–87.'
ista: 'De Alfaro L, Henzinger TA, Mang F. 2001. MCWEB: A model-checking tool for
web-site debugging. Proceedings of the 10th international conference on World
Wide Web. WWW: World Wide Web Conference, 86–87.'
mla: 'De Alfaro, Luca, et al. “MCWEB: A Model-Checking Tool for Web-Site Debugging.”
Proceedings of the 10th International Conference on World Wide Web, ACM,
2001, pp. 86–87.'
short: L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 10th International
Conference on World Wide Web, ACM, 2001, pp. 86–87.
conference:
end_date: 2000-05-05
location: Hong Kong, Hong Kong
name: 'WWW: World Wide Web Conference'
start_date: 2001-05-01
date_created: 2018-12-11T12:09:52Z
date_published: 2001-05-01T00:00:00Z
date_updated: 2023-05-08T09:39:02Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ir.webis.de/anthology/2001.wwwconf_conference-2001p.57/
month: '05'
oa_version: None
page: 86 - 87
publication: Proceedings of the 10th international conference on World Wide Web
publication_identifier:
isbn:
- '9781581133486'
publication_status: published
publisher: ACM
publist_id: '71'
quality_controlled: '1'
status: public
title: 'MCWEB: A model-checking tool for web-site debugging'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4632'
abstract:
- lang: eng
text: We present a compositional trace-based model for probabilistic systems. The
behavior of a system with probabilistic choice is a stochastic process, namely,
a probability distribution on traces, or “bundle.” Consequently, the semantics
of a system with both nondeterministic and probabilistic choice is a set of bundles.
The bundles of a composite system can be obtained by combining the bundles of
the components in a simple mathematical way. Refinement between systems is bundle
containment. We achieve assume-guarantee compositionality for bundle semantics
by introducing two scoping mechanisms. The first mechanism, which is standard
in compositional modeling, distinguishes inputs from outputs and hidden state.
The second mechanism, which arises in probabilistic systems, partitions the state
into probabilistically independent regions.
acknowledgement: This research was supported in part by the SRC contract 99-TJ-683.003,
the AFOSR MURI grant F49620-00-1-0327, the MARCO GSRC grant 98-DT-660, the NSF Theory
grant CCR-9988172, and the DARPA SEC grant F33615-C-98-3614.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ranjit
full_name: Jhala, Ranjit
last_name: Jhala
citation:
ama: 'De Alfaro L, Henzinger TA, Jhala R. Compositional methods for probabilistic
systems. In: Proceedings of the 12th International Conference on on Concurrency
Theory. Vol 2154. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2001:351-365.
doi:10.1007/3-540-44685-0_24'
apa: 'De Alfaro, L., Henzinger, T. A., & Jhala, R. (2001). Compositional methods
for probabilistic systems. In Proceedings of the 12th International Conference
on on Concurrency Theory (Vol. 2154, pp. 351–365). Aalborg, Denmark: Schloss
Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-44685-0_24'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Ranjit Jhala. “Compositional Methods
for Probabilistic Systems.” In Proceedings of the 12th International Conference
on on Concurrency Theory, 2154:351–65. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2001. https://doi.org/10.1007/3-540-44685-0_24.
ieee: L. De Alfaro, T. A. Henzinger, and R. Jhala, “Compositional methods for probabilistic
systems,” in Proceedings of the 12th International Conference on on Concurrency
Theory, Aalborg, Denmark, 2001, vol. 2154, pp. 351–365.
ista: 'De Alfaro L, Henzinger TA, Jhala R. 2001. Compositional methods for probabilistic
systems. Proceedings of the 12th International Conference on on Concurrency Theory.
CONCUR: Concurrency Theory, LNCS, vol. 2154, 351–365.'
mla: De Alfaro, Luca, et al. “Compositional Methods for Probabilistic Systems.”
Proceedings of the 12th International Conference on on Concurrency Theory,
vol. 2154, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2001, pp. 351–65,
doi:10.1007/3-540-44685-0_24.
short: L. De Alfaro, T.A. Henzinger, R. Jhala, in:, Proceedings of the 12th International
Conference on on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2001, pp. 351–365.
conference:
end_date: 2001-08-25
location: Aalborg, Denmark
name: 'CONCUR: Concurrency Theory'
start_date: 2001-08-20
date_created: 2018-12-11T12:09:51Z
date_published: 2001-08-13T00:00:00Z
date_updated: 2023-05-08T10:24:59Z
day: '13'
doi: 10.1007/3-540-44685-0_24
extern: '1'
intvolume: ' 2154'
language:
- iso: eng
month: '08'
oa_version: None
page: 351 - 365
publication: Proceedings of the 12th International Conference on on Concurrency Theory
publication_identifier:
isbn:
- '9783540424970'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '75'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Compositional methods for probabilistic systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2154
year: '2001'
...
---
_id: '4600'
abstract:
- lang: eng
text: 'Model checking is a practical tool for automated debugging of embedded software.
In model checking, a high-level description of a system is compared against a
logical correctness requirement to discover inconsistencies. Since model checking
is based on exhaustive state-space exploration and the size of the state space
of a design grows exponentially with the size of the description, scalability
remains a challenge. We have thus developed techniques for exploiting modular
design structure during model checking, and the model checker jMocha (Java MOdel-CHecking
Algorithm) is based on this theme. Instead of manipulating unstructured state-transition
graphs, it supports the hierarchical modeling framework of reactive modules. jMocha
is a growing interactive software environment for specification, simulation and
verification, and is intended as a vehicle for the development of new verification
algorithms and approaches. It is written in Java and uses native C-code BDD libraries
from VIS. jMocha offers: (1) a GUI that looks familiar to Windows/Java users;
(2) a simulator that displays traces in a message sequence chart fashion; (3)
requirements verification both by symbolic and enumerative model checking; (4)
implementation verification by checking trace containment; (5) a proof manager
that aids compositional and assume-guarantee reasoning; and (6) SLANG (Scripting
LANGuage) for the rapid and structured development of new verification algorithms.
jMocha is available publicly at ; it is a successor and extension of the original
Mocha tool that was entirely written in C.'
acknowledgement: 'We thank Himyanshu Anand, Ben Horowitz, Franjo Ivancic, Michael
McDougall, Marius Minea, Oliver Moeller. Shaz Qadeer, Sriram Rajamani, and Jean-Francois
Raskin for their assistance in the development of JMOCHA. The MOCHA project is funded
in part by the DARPA grant NAG2-1214, the NSF CAREER awards CCR95-01708 and CCR97-34115,
the NSF grant CCR99-70925, the NSF ITR grant CCR0085949, the MARC0 grant 98-DT-660,
and the SRC contracts 99-TJ-683.003 and 99-TJ-688. '
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Radu
full_name: Grosu, Radu
last_name: Grosu
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Myong
full_name: Kang, Myong
last_name: Kang
- first_name: Christoph
full_name: Kirsch, Christoph
last_name: Kirsch
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
- first_name: Bow
full_name: Wang, Bow
last_name: Wang
citation:
ama: 'Alur R, De Alfaro L, Grosu R, et al. jMocha: A model-checking tool that exploits
design structure. In: Proceedings of the 23rd International Conference on Software
Engineering. IEEE; 2001:835-836. doi:10.1109/ICSE.2001.919196'
apa: 'Alur, R., De Alfaro, L., Grosu, R., Henzinger, T. A., Kang, M., Kirsch, C.,
… Wang, B. (2001). jMocha: A model-checking tool that exploits design structure.
In Proceedings of the 23rd International Conference on Software Engineering
(pp. 835–836). IEEE. https://doi.org/10.1109/ICSE.2001.919196'
chicago: 'Alur, Rajeev, Luca De Alfaro, Radu Grosu, Thomas A Henzinger, Myong Kang,
Christoph Kirsch, Ritankar Majumdar, Freddy Mang, and Bow Wang. “JMocha: A Model-Checking
Tool That Exploits Design Structure.” In Proceedings of the 23rd International
Conference on Software Engineering, 835–36. IEEE, 2001. https://doi.org/10.1109/ICSE.2001.919196.'
ieee: 'R. Alur et al., “jMocha: A model-checking tool that exploits design
structure,” in Proceedings of the 23rd International Conference on Software
Engineering, 2001, pp. 835–836.'
ista: 'Alur R, De Alfaro L, Grosu R, Henzinger TA, Kang M, Kirsch C, Majumdar R,
Mang F, Wang B. 2001. jMocha: A model-checking tool that exploits design structure.
Proceedings of the 23rd International Conference on Software Engineering. ICSE:
Software Engineering, 835–836.'
mla: 'Alur, Rajeev, et al. “JMocha: A Model-Checking Tool That Exploits Design Structure.”
Proceedings of the 23rd International Conference on Software Engineering,
IEEE, 2001, pp. 835–36, doi:10.1109/ICSE.2001.919196.'
short: R. Alur, L. De Alfaro, R. Grosu, T.A. Henzinger, M. Kang, C. Kirsch, R. Majumdar,
F. Mang, B. Wang, in:, Proceedings of the 23rd International Conference on Software
Engineering, IEEE, 2001, pp. 835–836.
conference:
name: 'ICSE: Software Engineering'
date_created: 2018-12-11T12:09:41Z
date_published: 2001-08-07T00:00:00Z
date_updated: 2023-05-08T14:06:55Z
day: '07'
doi: 10.1109/ICSE.2001.919196
extern: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 835 - 836
publication: Proceedings of the 23rd International Conference on Software Engineering
publication_identifier:
isbn:
- '0769510507'
publication_status: published
publisher: IEEE
publist_id: '109'
quality_controlled: '1'
status: public
title: 'jMocha: A model-checking tool that exploits design structure'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4599'
abstract:
- lang: eng
text: 'State-space explosion is a fundamental obstacle in the formal verification
of designs and protocols. Several techniques for combating this problem have emerged
in the past few years, among which two are significant: partial-order reduction
and symbolic state-space search. In asynchronous systems, interleavings of independent
concurrent events are equivalent, and only a representative interleaving needs
to be explored to verify local properties. Partial-order methods exploit this
redundancy and visit only a subset of the reachable states. Symbolic techniques,
on the other hand, capture the transition relation of a system and the set of
reachable states as boolean functions. In many cases, these functions can be represented
compactly using binary decision diagrams (BDDs). Traditionally, the two techniques
have been practiced by two different schools—partial-order methods with enumerative
depth-first search for the analysis of asynchronous network protocols, and symbolic
breadth-first search for the analysis of synchronous hardware designs. We combine
both approaches and develop a method for using partial-order reduction techniques
in symbolic BDD-based invariant checking. We present theoretical results to prove
the correctness of the method, and experimental results to demonstrate its efficacy.'
acknowledgement: Gerard Holzmann provided us with information on SPIN. Ken McMillan
and Doron Peled contributed through discussions. The VIS group at UC Berkeley and
Rajeev Ranjan in particular helped with the experiments.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Robert
full_name: Brayton, Robert
last_name: Brayton
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Shaz
full_name: Qadeer, Shaz
last_name: Qadeer
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: Alur R, Brayton R, Henzinger TA, Qadeer S, Rajamani S. Partial-order reduction
in symbolic state-space exploration. Formal Methods in System Design. 2001;18(2):97-116.
doi:10.1023/A:1008767206905
apa: Alur, R., Brayton, R., Henzinger, T. A., Qadeer, S., & Rajamani, S. (2001).
Partial-order reduction in symbolic state-space exploration. Formal Methods
in System Design. Springer. https://doi.org/10.1023/A:1008767206905
chicago: Alur, Rajeev, Robert Brayton, Thomas A Henzinger, Shaz Qadeer, and Sriram
Rajamani. “Partial-Order Reduction in Symbolic State-Space Exploration.” Formal
Methods in System Design. Springer, 2001. https://doi.org/10.1023/A:1008767206905.
ieee: R. Alur, R. Brayton, T. A. Henzinger, S. Qadeer, and S. Rajamani, “Partial-order
reduction in symbolic state-space exploration,” Formal Methods in System Design,
vol. 18, no. 2. Springer, pp. 97–116, 2001.
ista: Alur R, Brayton R, Henzinger TA, Qadeer S, Rajamani S. 2001. Partial-order
reduction in symbolic state-space exploration. Formal Methods in System Design.
18(2), 97–116.
mla: Alur, Rajeev, et al. “Partial-Order Reduction in Symbolic State-Space Exploration.”
Formal Methods in System Design, vol. 18, no. 2, Springer, 2001, pp. 97–116,
doi:10.1023/A:1008767206905.
short: R. Alur, R. Brayton, T.A. Henzinger, S. Qadeer, S. Rajamani, Formal Methods
in System Design 18 (2001) 97–116.
date_created: 2018-12-11T12:09:41Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-08T12:22:38Z
day: '01'
doi: 10.1023/A:1008767206905
extern: '1'
intvolume: ' 18'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 97 - 116
publication: Formal Methods in System Design
publication_identifier:
issn:
- 0925-9856
publication_status: published
publisher: Springer
publist_id: '108'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Partial-order reduction in symbolic state-space exploration
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '2001'
...
---
_id: '4622'
abstract:
- lang: eng
text: Conventional type systems specify interfaces in terms of values and domains.
We present a light-weight formalism that captures the temporal aspects of software
component interfaces. Specifically, we use an automata-based language to capture
both input assumptions about the order in which the methods of a component are
called, and output guarantees about the order in which the component calls external
methods. The formalism supports automatic compatability checks between interface
models, and thus constitutes a type system for component interaction. Unlike traditional
uses of automata, our formalism is based on an optimistic approach to composition,
and on an alternating approach to design refinement. According to the optimistic
approach, two components are compatible if there is some environment that can
make them work together. According to the alternating approach, one interface
refines another if it has weaker input assumptions, and stronger output guarantees.
We show that these notions have game-theoretic foundations that lead to efficient
algorithms for checking compatibility and refinement.
acknowledgement: We thank Edward A. Lee, Xiaojun Liu, Freddy Mang, and Yuhong Xiong
for fruitful discussions. This research was supported in part by the AFOSR MURI
grant F49620-00-1-0327, the DARPA MoBIES grant F33615-00-C-1703, the MARCO GSRC
grant 98-DT-660, the NSF Theory grant CCR-9988172, and the NSF ITR grant CCR-0085949.
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'De Alfaro L, Henzinger TA. Interface automata. In: Proceedings of the 8th
European Software Engineering Conference. ACM; 2001:109-120. doi:10.1145/503209.503226'
apa: 'De Alfaro, L., & Henzinger, T. A. (2001). Interface automata. In Proceedings
of the 8th European software engineering conference (pp. 109–120). Vienna,
Austria: ACM. https://doi.org/10.1145/503209.503226'
chicago: De Alfaro, Luca, and Thomas A Henzinger. “Interface Automata.” In Proceedings
of the 8th European Software Engineering Conference, 109–20. ACM, 2001. https://doi.org/10.1145/503209.503226.
ieee: L. De Alfaro and T. A. Henzinger, “Interface automata,” in Proceedings
of the 8th European software engineering conference, Vienna, Austria, 2001,
pp. 109–120.
ista: 'De Alfaro L, Henzinger TA. 2001. Interface automata. Proceedings of the 8th
European software engineering conference. FSE: Foundations of Software Engineering,
109–120.'
mla: De Alfaro, Luca, and Thomas A. Henzinger. “Interface Automata.” Proceedings
of the 8th European Software Engineering Conference, ACM, 2001, pp. 109–20,
doi:10.1145/503209.503226.
short: L. De Alfaro, T.A. Henzinger, in:, Proceedings of the 8th European Software
Engineering Conference, ACM, 2001, pp. 109–120.
conference:
end_date: 2001-09-14
location: Vienna, Austria
name: 'FSE: Foundations of Software Engineering'
start_date: 2001-09-10
date_created: 2018-12-11T12:09:48Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-08T12:01:02Z
day: '01'
doi: 10.1145/503209.503226
extern: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 109 - 120
publication: Proceedings of the 8th European software engineering conference
publication_identifier:
isbn:
- '9781581133905'
publication_status: published
publisher: ACM
publist_id: '83'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interface automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4623'
abstract:
- lang: eng
text: We classify component-based models of computation into component models and
interface models. A component model specifies for each component howthe component
behaves in an arbitrary environment; an interface model specifies for each component
what the component expects from the environment. Component models support compositional
abstraction, and therefore component-based verification. Interface models support
compositional refinement, and therefore componentbased design. Many aspects of
interface models, such as compatibility and refinement checking between interfaces,
are properly viewed in a gametheoretic setting, where the input and output values
of an interface are chosen by different players.
acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
the DARPA ITO grant F33615-00-C-1693, the MARCO grant 98-DT-660, and the NSF ITR
grant CCR-0085949.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'De Alfaro L, Henzinger TA. Interface theories for component-based design.
In: Proceedings of the 1st International Workshop on Embedded Software.
Vol 2211. ACM; 2001:148-165. doi:10.1007/3-540-45449-7_11'
apa: 'De Alfaro, L., & Henzinger, T. A. (2001). Interface theories for component-based
design. In Proceedings of the 1st International Workshop on Embedded Software
(Vol. 2211, pp. 148–165). Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7_11'
chicago: De Alfaro, Luca, and Thomas A Henzinger. “Interface Theories for Component-Based
Design.” In Proceedings of the 1st International Workshop on Embedded Software,
2211:148–65. ACM, 2001. https://doi.org/10.1007/3-540-45449-7_11.
ieee: L. De Alfaro and T. A. Henzinger, “Interface theories for component-based
design,” in Proceedings of the 1st International Workshop on Embedded Software,
Tahoe City, CA, USA, 2001, vol. 2211, pp. 148–165.
ista: 'De Alfaro L, Henzinger TA. 2001. Interface theories for component-based design.
Proceedings of the 1st International Workshop on Embedded Software. EMSOFT: Embedded
Software , LNCS, vol. 2211, 148–165.'
mla: De Alfaro, Luca, and Thomas A. Henzinger. “Interface Theories for Component-Based
Design.” Proceedings of the 1st International Workshop on Embedded Software,
vol. 2211, ACM, 2001, pp. 148–65, doi:10.1007/3-540-45449-7_11.
short: L. De Alfaro, T.A. Henzinger, in:, Proceedings of the 1st International Workshop
on Embedded Software, ACM, 2001, pp. 148–165.
conference:
end_date: 2001-10-10
location: Tahoe City, CA, USA
name: 'EMSOFT: Embedded Software '
start_date: 2001-10-08
date_created: 2018-12-11T12:09:48Z
date_published: 2001-09-26T00:00:00Z
date_updated: 2023-05-08T12:11:20Z
day: '26'
doi: 10.1007/3-540-45449-7_11
extern: '1'
intvolume: ' 2211'
language:
- iso: eng
month: '09'
oa_version: None
page: 148 - 165
publication: Proceedings of the 1st International Workshop on Embedded Software
publication_identifier:
isbn:
- '9783540426738'
publication_status: published
publisher: ACM
publist_id: '84'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interface theories for component-based design
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2211
year: '2001'
...
---
_id: '4564'
abstract:
- lang: eng
text: This paper presents a concept for integrating the embedded programming methodology
Giotto and the object-oriented AOCS Framework to create an environment for the
rapid development of distributed software for safety-critical embedded control
systems with hard real-time requirements of the kind typically found in aerospace
applications.
acknowledgement: 'This research was supported in part by DARPA under grants F336 15-C-98-36
14, F33615-00-(2-1693, and F33615-00-C-1703, and by MARC0 under grant 98-DT-660. '
article_processing_charge: No
author:
- first_name: Timothy
full_name: Brown, Timothy
last_name: Brown
- first_name: Alessandro
full_name: Pasetti, Alessandro
last_name: Pasetti
- first_name: Wolfgang
full_name: Pree, Wolfgang
last_name: Pree
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Christoph
full_name: Kirsch, Christoph
last_name: Kirsch
citation:
ama: 'Brown T, Pasetti A, Pree W, Henzinger TA, Kirsch C. A reusable and platform-independent
framework for distributed control systems. In: Proceedings of the 20th Digital
Avionics Systems Conference. IEEE; 2001:1-11. doi:10.1109/DASC.2001.964169'
apa: 'Brown, T., Pasetti, A., Pree, W., Henzinger, T. A., & Kirsch, C. (2001).
A reusable and platform-independent framework for distributed control systems.
In Proceedings of the 20th Digital Avionics Systems Conference (pp. 1–11).
Daytona Beach, FL, USA: IEEE. https://doi.org/10.1109/DASC.2001.964169'
chicago: Brown, Timothy, Alessandro Pasetti, Wolfgang Pree, Thomas A Henzinger,
and Christoph Kirsch. “A Reusable and Platform-Independent Framework for Distributed
Control Systems.” In Proceedings of the 20th Digital Avionics Systems Conference,
1–11. IEEE, 2001. https://doi.org/10.1109/DASC.2001.964169.
ieee: T. Brown, A. Pasetti, W. Pree, T. A. Henzinger, and C. Kirsch, “A reusable
and platform-independent framework for distributed control systems,” in Proceedings
of the 20th Digital Avionics Systems Conference, Daytona Beach, FL, USA, 2001,
pp. 1–11.
ista: 'Brown T, Pasetti A, Pree W, Henzinger TA, Kirsch C. 2001. A reusable and
platform-independent framework for distributed control systems. Proceedings of
the 20th Digital Avionics Systems Conference. DASC: Digital Avionics Systems Conference,
1–11.'
mla: Brown, Timothy, et al. “A Reusable and Platform-Independent Framework for Distributed
Control Systems.” Proceedings of the 20th Digital Avionics Systems Conference,
IEEE, 2001, pp. 1–11, doi:10.1109/DASC.2001.964169.
short: T. Brown, A. Pasetti, W. Pree, T.A. Henzinger, C. Kirsch, in:, Proceedings
of the 20th Digital Avionics Systems Conference, IEEE, 2001, pp. 1–11.
conference:
end_date: 2001-10-18
location: Daytona Beach, FL, USA
name: 'DASC: Digital Avionics Systems Conference'
start_date: 2001-10-14
date_created: 2018-12-11T12:09:30Z
date_published: 2001-08-06T00:00:00Z
date_updated: 2023-05-09T12:23:16Z
day: '06'
doi: 10.1109/DASC.2001.964169
extern: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 1 - 11
publication: Proceedings of the 20th Digital Avionics Systems Conference
publication_identifier:
isbn:
- '0780370341'
publication_status: published
publisher: IEEE
publist_id: '143'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A reusable and platform-independent framework for distributed control systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4477'
abstract:
- lang: eng
text: The assume-guarantee paradigm is a powerful divide-and-conquer mechanism for
decomposing a verification task about a system into subtasks about the individual
components of the system. The key to assume-guarantee reasoning is to consider
each component not in isolation, but in conjunction with assumptions about the
context of the component. Assume-guarantee principles are known for purely concurrent
contexts, which constrain the input data of a component, as well as for purely
sequential contexts, which constrain the entry configurations of a component.
We present a model for hierarchical system design which permits the arbitrary
nesting of parallel as well as serial composition, and which supports an assume-guarantee
principle for mixed parallel-serial contexts. Our model also supports both discrete
and continuous processes, and is therefore well-suited for the modeling and analysis
of embedded software systems which interact with real-world environments. Using
an example of two cooperating robots, we show refinement between a high-level
model which specifies continuous timing constraints and an implementation which
relies on discrete sampling.
acknowledgement: Support for this research was provided in part by the AFOSR MURI
grant F49620- 00-1-0327, and the DARPA SEC grant F33615-C-98-3614, the MARCO GSRC
grant 98-DT-660, the NSF ITR grant CCR-0085949.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Marius
full_name: Minea, Marius
last_name: Minea
- first_name: Vinayak
full_name: Prabhu, Vinayak
last_name: Prabhu
citation:
ama: 'Henzinger TA, Minea M, Prabhu V. Assume-guarantee reasoning for hierarchical
hybrid systems. In: Proceedings of the 4th International Workshop on Hybrid
Systems. Vol 2034. Springer; 2001:275-290. doi:10.1007/3-540-45351-2_24'
apa: 'Henzinger, T. A., Minea, M., & Prabhu, V. (2001). Assume-guarantee reasoning
for hierarchical hybrid systems. In Proceedings of the 4th International Workshop
on Hybrid Systems (Vol. 2034, pp. 275–290). Rome, Italy: Springer. https://doi.org/10.1007/3-540-45351-2_24'
chicago: Henzinger, Thomas A, Marius Minea, and Vinayak Prabhu. “Assume-Guarantee
Reasoning for Hierarchical Hybrid Systems.” In Proceedings of the 4th International
Workshop on Hybrid Systems, 2034:275–90. Springer, 2001. https://doi.org/10.1007/3-540-45351-2_24.
ieee: T. A. Henzinger, M. Minea, and V. Prabhu, “Assume-guarantee reasoning for
hierarchical hybrid systems,” in Proceedings of the 4th International Workshop
on Hybrid Systems, Rome, Italy, 2001, vol. 2034, pp. 275–290.
ista: 'Henzinger TA, Minea M, Prabhu V. 2001. Assume-guarantee reasoning for hierarchical
hybrid systems. Proceedings of the 4th International Workshop on Hybrid Systems.
HSCC: Hybrid Systems - Computation and Control, LNCS, vol. 2034, 275–290.'
mla: Henzinger, Thomas A., et al. “Assume-Guarantee Reasoning for Hierarchical Hybrid
Systems.” Proceedings of the 4th International Workshop on Hybrid Systems,
vol. 2034, Springer, 2001, pp. 275–90, doi:10.1007/3-540-45351-2_24.
short: T.A. Henzinger, M. Minea, V. Prabhu, in:, Proceedings of the 4th International
Workshop on Hybrid Systems, Springer, 2001, pp. 275–290.
conference:
end_date: 2001-03-30
location: Rome, Italy
name: 'HSCC: Hybrid Systems - Computation and Control'
start_date: 2001-03-28
date_created: 2018-12-11T12:09:03Z
date_published: 2001-03-14T00:00:00Z
date_updated: 2023-05-09T14:47:37Z
day: '14'
doi: 10.1007/3-540-45351-2_24
extern: '1'
intvolume: ' 2034'
language:
- iso: eng
month: '03'
oa_version: None
page: 275 - 290
publication: Proceedings of the 4th International Workshop on Hybrid Systems
publication_identifier:
isbn:
- '9783540418665'
publication_status: published
publisher: Springer
publist_id: '250'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Assume-guarantee reasoning for hierarchical hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2034
year: '2001'
...
---
_id: '4478'
abstract:
- lang: eng
text: Giotto is a principled, tool-supported design methodology for implementing
embedded control systems on platforms of possibly distributed sensors, actuators,
CPUs, and networks. Giotto is based on the principle that time-triggered task
invocations plus time-triggered mode switches can form the abstract essence of
programming real-time control systems. Giotto consists of a programming language
with a formal semantics, and a retargetable compiler and runtime library. Giotto
supports the automation of control system design by strictly separating platform-independent
functionality and timing concerns from platform-dependent scheduling and communication
issues. The time-triggered predictability of Giotto makes it particularly suitable
for safety-critical applications with hard real-time constraints. We illustrate
the platform-independence and time-triggered execution of Giotto by coordinating
a heterogeneous flock of Intel x86 robots and Lego Mindstorms robots.
acknowledgement: We thank Rupak Majumdar for implementing a prototype Giotto compiler
for Lego Mindstorms robots. We thank Dmitry Derevyanko and Winthrop Williams for
building our Intel x86 robots. We thank Edward Lee and Xiaojun Liu for help with
a Ptolemy II [4] implementation of Giotto. This research was supported in part by
the DARPA SEC grant F33615-C-98-3614, the DARPA MoBIES grant F33615- 00-C-1703,
the MARCO GSRC grant 98-DT-660, the AFOSR MURI grant F49620-00-1-0327, and the NSF
ITR grant CCR-0085949.
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Benjamin
full_name: Horowitz, Benjamin
last_name: Horowitz
- first_name: Christoph
full_name: Kirsch, Christoph
last_name: Kirsch
citation:
ama: 'Henzinger TA, Horowitz B, Kirsch C. Embedded control systems development with
Giotto. In: Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers
and Tools for Embedded Systems. ACM; 2001:64-72. doi:10.1145/384197.384208'
apa: 'Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Embedded control
systems development with Giotto. In Proceedings of the 2nd ACM SIGPLAN workshop
on Languages, compilers and tools for embedded systems (pp. 64–72). New York,
NY, United States: ACM. https://doi.org/10.1145/384197.384208'
chicago: Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Embedded
Control Systems Development with Giotto.” In Proceedings of the 2nd ACM SIGPLAN
Workshop on Languages, Compilers and Tools for Embedded Systems, 64–72. ACM,
2001. https://doi.org/10.1145/384197.384208.
ieee: T. A. Henzinger, B. Horowitz, and C. Kirsch, “Embedded control systems development
with Giotto,” in Proceedings of the 2nd ACM SIGPLAN workshop on Languages,
compilers and tools for embedded systems, New York, NY, United States, 2001,
pp. 64–72.
ista: 'Henzinger TA, Horowitz B, Kirsch C. 2001. Embedded control systems development
with Giotto. Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers
and tools for embedded systems. LCTES: Languages, Compilers, and Tools for Embedded
Systems, 64–72.'
mla: Henzinger, Thomas A., et al. “Embedded Control Systems Development with Giotto.”
Proceedings of the 2nd ACM SIGPLAN Workshop on Languages, Compilers and Tools
for Embedded Systems, ACM, 2001, pp. 64–72, doi:10.1145/384197.384208.
short: T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 2nd ACM SIGPLAN
Workshop on Languages, Compilers and Tools for Embedded Systems, ACM, 2001, pp.
64–72.
conference:
location: New York, NY, United States
name: 'LCTES: Languages, Compilers, and Tools for Embedded Systems'
date_created: 2018-12-11T12:09:03Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-10T09:37:20Z
day: '01'
doi: 10.1145/384197.384208
extern: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 64 - 72
publication: Proceedings of the 2nd ACM SIGPLAN workshop on Languages, compilers and
tools for embedded systems
publication_identifier:
isbn:
- '9781581134254'
publication_status: published
publisher: ACM
publist_id: '251'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Embedded control systems development with Giotto
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4479'
abstract:
- lang: eng
text: Giotto provides an abstract programmer’s model for the implementation of embedded
control systems with hard real-time constraints. A typical control application
consists of periodic software tasks together with a mode switching logic for enabling
and disabling tasks. Giotto specifies time-triggered sensor readings, task invocations,
and mode switches independent of any implementation platform. Giotto can be annotated
with platform constraints such as task-to-host mappings, and task and communication
schedules. The annotations are directives for the Giotto compiler, but they do
not alter the functionality and timing of a Giotto program. By separating the
platform-independent from the platform-dependent concerns, Giotto enables a great
deal of flexibility in choosing control platforms as well as a great deal of automation
in the validation and synthesis of control software. The time-triggered nature
of Giotto achieves timing predictability, which makes Giotto particularly suitable
for safety-critical applications.
acknowledgement: This research was supported in part by the DARPA SEC grant F33615-C-98-3614
and by the MARCO GSRC grant 98-DT-660.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Benjamin
full_name: Horowitz, Benjamin
last_name: Horowitz
- first_name: Christoph
full_name: Kirsch, Christoph
last_name: Kirsch
citation:
ama: 'Henzinger TA, Horowitz B, Kirsch C. Giotto: A time-triggered language for
embedded programming. In: Proceedings of the 1st International Workshop on
Embedded Software. Vol 2211. ACM; 2001:166-184. doi:10.1007/3-540-45449-7_12'
apa: 'Henzinger, T. A., Horowitz, B., & Kirsch, C. (2001). Giotto: A time-triggered
language for embedded programming. In Proceedings of the 1st International
Workshop on Embedded Software (Vol. 2211, pp. 166–184). Tahoe City, CA, USA:
ACM. https://doi.org/10.1007/3-540-45449-7_12'
chicago: 'Henzinger, Thomas A, Benjamin Horowitz, and Christoph Kirsch. “Giotto:
A Time-Triggered Language for Embedded Programming.” In Proceedings of the
1st International Workshop on Embedded Software, 2211:166–84. ACM, 2001. https://doi.org/10.1007/3-540-45449-7_12.'
ieee: 'T. A. Henzinger, B. Horowitz, and C. Kirsch, “Giotto: A time-triggered language
for embedded programming,” in Proceedings of the 1st International Workshop
on Embedded Software, Tahoe City, CA, USA, 2001, vol. 2211, pp. 166–184.'
ista: 'Henzinger TA, Horowitz B, Kirsch C. 2001. Giotto: A time-triggered language
for embedded programming. Proceedings of the 1st International Workshop on Embedded
Software. EMSOFT: Embedded Software , LNCS, vol. 2211, 166–184.'
mla: 'Henzinger, Thomas A., et al. “Giotto: A Time-Triggered Language for Embedded
Programming.” Proceedings of the 1st International Workshop on Embedded Software,
vol. 2211, ACM, 2001, pp. 166–84, doi:10.1007/3-540-45449-7_12.'
short: T.A. Henzinger, B. Horowitz, C. Kirsch, in:, Proceedings of the 1st International
Workshop on Embedded Software, ACM, 2001, pp. 166–184.
conference:
end_date: 2001-10-10
location: Tahoe City, CA, USA
name: 'EMSOFT: Embedded Software '
start_date: 2001-10-08
date_created: 2018-12-11T12:09:04Z
date_published: 2001-09-26T00:00:00Z
date_updated: 2023-05-10T09:42:10Z
day: '26'
doi: 10.1007/3-540-45449-7_12
extern: '1'
intvolume: ' 2211'
language:
- iso: eng
month: '09'
oa_version: None
page: 166 - 184
publication: Proceedings of the 1st International Workshop on Embedded Software
publication_identifier:
isbn:
- '9783540426738'
publication_status: published
publisher: ACM
publist_id: '252'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Giotto: A time-triggered language for embedded programming'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2211
year: '2001'
...
---
_id: '4475'
abstract:
- lang: eng
text: We provide an overview of the current status of HYTECH, and reflect on some
of the lessons learned from our experiences with the tool. HYTECH is a symbolic
model checker for mixed discrete-continuous systems that are modeled as automata
with piecewise-constant polyhedral differential inclusions. The use of a formal
input language and automated procedures for state-space traversal lay the foundation
for formally verifying properties of hybrid dynamical systems. We describe some
recent experiences analyzing three hybrid systems. We point out the successes
and limitations of the tool. The analysis procedure has been extended in a number
of ways to address some of the tool's shortcomings. We evaluate these extensions,
and conclude with some desiderata for verification tools for hybrid systems.
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Joerg
full_name: Preussig, Joerg
last_name: Preussig
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Preussig J, Wong Toi H. Some lessons from the HYTECH experience.
In: Proceedings of the 40th IEEE Conference on Decision and Control. Vol
3. IEEE; 2001:2887-2892. doi:10.1109/.2001.980714'
apa: 'Henzinger, T. A., Preussig, J., & Wong Toi, H. (2001). Some lessons from
the HYTECH experience. In Proceedings of the 40th IEEE Conference on Decision
and Control (Vol. 3, pp. 2887–2892). Orlando, FL, USA: IEEE. https://doi.org/10.1109/.2001.980714'
chicago: Henzinger, Thomas A, Joerg Preussig, and Howard Wong Toi. “Some Lessons
from the HYTECH Experience.” In Proceedings of the 40th IEEE Conference on
Decision and Control, 3:2887–92. IEEE, 2001. https://doi.org/10.1109/.2001.980714.
ieee: T. A. Henzinger, J. Preussig, and H. Wong Toi, “Some lessons from the HYTECH
experience,” in Proceedings of the 40th IEEE Conference on Decision and Control,
Orlando, FL, USA, 2001, vol. 3, pp. 2887–2892.
ista: 'Henzinger TA, Preussig J, Wong Toi H. 2001. Some lessons from the HYTECH
experience. Proceedings of the 40th IEEE Conference on Decision and Control. CDC:
Decision and Control vol. 3, 2887–2892.'
mla: Henzinger, Thomas A., et al. “Some Lessons from the HYTECH Experience.” Proceedings
of the 40th IEEE Conference on Decision and Control, vol. 3, IEEE, 2001, pp.
2887–92, doi:10.1109/.2001.980714.
short: T.A. Henzinger, J. Preussig, H. Wong Toi, in:, Proceedings of the 40th IEEE
Conference on Decision and Control, IEEE, 2001, pp. 2887–2892.
conference:
end_date: 2001-12-07
location: Orlando, FL, USA
name: 'CDC: Decision and Control'
start_date: 2001-12-04
date_created: 2018-12-11T12:09:02Z
date_published: 2001-05-01T00:00:00Z
date_updated: 2023-05-10T09:47:20Z
day: '01'
doi: 10.1109/.2001.980714
extern: '1'
intvolume: ' 3'
language:
- iso: eng
month: '05'
oa_version: None
page: 2887 - 2892
publication: Proceedings of the 40th IEEE Conference on Decision and Control
publication_identifier:
isbn:
- '0780370619'
publication_status: published
publisher: IEEE
publist_id: '253'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Some lessons from the HYTECH experience
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '2001'
...
---
_id: '4449'
abstract:
- lang: eng
text: Embedded software is software that interacts with physical processes. As em-
bedded systems increasingly permeate our daily lives on all levels, from micros-
copic devices to international networks, the cost-efficient development of reliable
embedded software is one of the grand challenges in computer science today. The
purpose of the workshop is to bring together researchers in all areas of computer
science that are traditionally distinct but relevant to embedded software develop-
ment, and to incubate a research community in this way. The workshop aims to cover
all aspects of the design and implementation of embedded software, inclu- ding
operating systems and middleware, programming languages and compilers, modeling
and validation, software engineering and programming methodologies, scheduling
and execution time analysis, networking and fault tolerance, as well as application
areas, such as embedded control, real-time signal processing, and telecommunications.
alternative_title:
- LNCS
article_processing_charge: No
citation:
ama: 'Henzinger TA, ed. EMSOFT: Embedded Software. Vol 2211. ACM; 2001. doi:10.1007/3-540-45449-7'
apa: 'Henzinger, T. A. (Ed.). (2001). EMSOFT: Embedded Software (Vol. 2211).
Presented at the EMSOFT 2001: Embedded Software, Tahoe City, CA, USA: ACM. https://doi.org/10.1007/3-540-45449-7'
chicago: 'Henzinger, Thomas A, ed. EMSOFT: Embedded Software. Vol. 2211.
ACM, 2001. https://doi.org/10.1007/3-540-45449-7.'
ieee: 'T. A. Henzinger, Ed., EMSOFT: Embedded Software, vol. 2211. ACM, 2001.'
ista: 'Henzinger TA ed. 2001. EMSOFT: Embedded Software, ACM,p.'
mla: 'Henzinger, Thomas A., editor. EMSOFT: Embedded Software. Vol. 2211,
ACM, 2001, doi:10.1007/3-540-45449-7.'
short: 'T.A. Henzinger, ed., EMSOFT: Embedded Software, ACM, 2001.'
conference:
end_date: 2001-10-10
location: Tahoe City, CA, USA
name: 'EMSOFT 2001: Embedded Software'
start_date: 2001-10-08
date_created: 2018-12-11T12:08:54Z
date_published: 2001-09-26T00:00:00Z
date_updated: 2023-05-10T09:53:17Z
day: '26'
doi: 10.1007/3-540-45449-7
editor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
extern: '1'
intvolume: ' 2211'
language:
- iso: eng
month: '09'
oa_version: None
publication_identifier:
isbn:
- '9783540426738'
publication_status: published
publisher: ACM
publist_id: '283'
quality_controlled: '1'
status: public
title: 'EMSOFT: Embedded Software'
type: conference_editor
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2211
year: '2001'
...
---
_id: '4278'
abstract:
- lang: eng
text: 'The ability of species to migrate that has interested ecologists for many
years. Now that so many species and ecosystems face major environmental change,
the ability of species to adapt to these changes by dispersing, migrating, or
moving between different patches of habitat can be crucial to ensuring their survivial.
This book provides a timely and wide-ranging overview of the study of dispersal
and incorporates much of the latest research. The causes, mechanisms, and consequences
of dispersal at the individual, population, species and community levels are considered.
The potential of new techniques and models for studying dispersal, drawn from
molecular biology and demography, is also explored. Perspectives and insights
are offered from the fields of evolution, conservation biology and genetics. Throughout
the book, theoretical approaches are combined with empirical data, and care has
been taken to include examples from as wide a range of species as possible. '
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. The evolutionary consequences of gene flow and local adaptation:
Future approaches. In: Dispersal. Oxford University Press; 2001.'
apa: 'Barton, N. H. (2001). The evolutionary consequences of gene flow and local
adaptation: Future approaches. In Dispersal. Oxford University Press.'
chicago: 'Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local
Adaptation: Future Approaches.” In Dispersal. Oxford University Press,
2001.'
ieee: 'N. H. Barton, “The evolutionary consequences of gene flow and local adaptation:
Future approaches,” in Dispersal, Oxford University Press, 2001.'
ista: 'Barton NH. 2001.The evolutionary consequences of gene flow and local adaptation:
Future approaches. In: Dispersal. .'
mla: 'Barton, Nicholas H. “The Evolutionary Consequences of Gene Flow and Local
Adaptation: Future Approaches.” Dispersal, Oxford University Press, 2001.'
short: N.H. Barton, in:, Dispersal, Oxford University Press, 2001.
date_created: 2018-12-11T12:08:00Z
date_published: 2001-04-01T00:00:00Z
date_updated: 2023-05-10T09:57:10Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.nhbs.com/dispersal-book
month: '04'
oa_version: None
publication: Dispersal
publication_identifier:
isbn:
- '9780198506591'
publication_status: published
publisher: Oxford University Press
publist_id: '1812'
quality_controlled: '1'
status: public
title: 'The evolutionary consequences of gene flow and local adaptation: Future approaches'
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4200'
abstract:
- lang: eng
text: Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a
striking phenotype in which the eyes and telencephalon are reduced or absent and
diencephalic fates expand to the front of the brain. Here we show that mb1(-/-)
embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding
protein, Axin1. The amino-acid substitution present in the mbl allele abolishes
the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore,
Gsk3 activity may be decreased in mbl(-/-) embryos and in support of this possibility,
overexpression of either wild-type Axin1 or Gsk3 beta can restore eye and telencephalic
fates to mb1(-/-) embryos. Our data reveal a crucial role for Axin1-dependent
inhibition of the Wnt pathway in the early regional subdivision of the anterior
neural plate into telencephalic, diencephalic, and eye-forming territories.
acknowledgement: "We thank many colleagues who provided reagents that enabled us to
test axin1 and several other genes as candidates for the mbl mutation. In particular,
we are indebted to Masahiko Hibi, Ken Irvine, Antonio Jacinto, Yun-Jin Jiang, Julian
Lewis, and Tom Vogt for help and advice. We thank Ajay Chitnis and Dana Zivkovic
for providing information prior to publication. This study was supported primarily
by grants from the EMBO and EC to C.P.H., Wellcome Trust and EC to S.W.W., from
the MRC to D.S., from Naito to M.T., from the DHGP to G.J.R. and R.G., and from
the CRC/ICR to T.D. P.C. was supported by a PhD studentship from Fundação para a
Ciência e Tecnologia, Programa PRAXIS XXI. S.W.W. is a Wellcome Trust Senior Research
Fellow.\r\n\r\nThe publication costs of this article were defrayed in part by payment
of page charges. This article must therefore be hereby marked “advertisement” in
accordance with 18 USC section 1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Corinne
full_name: Houart, Corinne
last_name: Houart
- first_name: Masaya
full_name: Take Uchi, Masaya
last_name: Take Uchi
- first_name: Gerd
full_name: Rauch, Gerd
last_name: Rauch
- first_name: Neville
full_name: Young, Neville
last_name: Young
- first_name: Pedro
full_name: Coutinho, Pedro
last_name: Coutinho
- first_name: Ichiro
full_name: Masai, Ichiro
last_name: Masai
- first_name: Luca
full_name: Caneparo, Luca
last_name: Caneparo
- first_name: Miguel
full_name: Concha, Miguel
last_name: Concha
- first_name: Robert
full_name: Geisler, Robert
last_name: Geisler
- first_name: Trevor
full_name: Dale, Trevor
last_name: Dale
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
- first_name: Derek
full_name: Stemple, Derek
last_name: Stemple
citation:
ama: Heisenberg C-PJ, Houart C, Take Uchi M, et al. A mutation in the Gsk3-binding
domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon
and eyes to diencephalon. Genes and Development. 2001;15(11):1427-1434.
doi:10.1101/gad.194301
apa: Heisenberg, C.-P. J., Houart, C., Take Uchi, M., Rauch, G., Young, N., Coutinho,
P., … Stemple, D. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1
leads to a fate transformation of telencephalon and eyes to diencephalon. Genes
and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.194301
chicago: Heisenberg, Carl-Philipp J, Corinne Houart, Masaya Take Uchi, Gerd Rauch,
Neville Young, Pedro Coutinho, Ichiro Masai, et al. “A Mutation in the Gsk3-Binding
Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon
and Eyes to Diencephalon.” Genes and Development. Cold Spring Harbor Laboratory
Press, 2001. https://doi.org/10.1101/gad.194301.
ieee: C.-P. J. Heisenberg et al., “A mutation in the Gsk3-binding domain
of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon
and eyes to diencephalon,” Genes and Development, vol. 15, no. 11. Cold
Spring Harbor Laboratory Press, pp. 1427–1434, 2001.
ista: Heisenberg C-PJ, Houart C, Take Uchi M, Rauch G, Young N, Coutinho P, Masai
I, Caneparo L, Concha M, Geisler R, Dale T, Wilson S, Stemple D. 2001. A mutation
in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation
of telencephalon and eyes to diencephalon. Genes and Development. 15(11), 1427–1434.
mla: Heisenberg, Carl-Philipp J., et al. “A Mutation in the Gsk3-Binding Domain
of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon
and Eyes to Diencephalon.” Genes and Development, vol. 15, no. 11, Cold
Spring Harbor Laboratory Press, 2001, pp. 1427–34, doi:10.1101/gad.194301.
short: C.-P.J. Heisenberg, C. Houart, M. Take Uchi, G. Rauch, N. Young, P. Coutinho,
I. Masai, L. Caneparo, M. Concha, R. Geisler, T. Dale, S. Wilson, D. Stemple,
Genes and Development 15 (2001) 1427–1434.
date_created: 2018-12-11T12:07:33Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-10T12:27:02Z
day: '01'
doi: 10.1101/gad.194301
extern: '1'
external_id:
pmid:
- '11390362'
intvolume: ' 15'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312705/
month: '06'
oa: 1
oa_version: Published Version
page: 1427 - 1434
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '1916'
quality_controlled: '1'
status: public
title: A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads
to a fate transformation of telencephalon and eyes to diencephalon
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '4266'
abstract:
- lang: eng
text: Hybridization may influence evolution in a variety of ways. If hybrids are
less fit, the geographical range of ecologically divergent populations may be
limited, and prezygotic reproductive isolation may be reinforced. If some hybrid
genotypes are fitter than one or both parents, at least in some environments,
then hybridization could make a positive contribution. Single alleles that are
at an advantage in the alternative environment and genetic background will introgress
readily, although such introgression may be hard to detect. 'Hybrid speciation',
in which fit combinations of alleles are established, is more problematic; its
likelihood depends on how divergent populations meet, and on the structure of
epistasis. These issues are illustrated using Fisher's model of stabilizing selection
on multiple traits, under which reproductive isolation evolves as a side-effect
of adaptation in allopatry. This confirms a priori arguments that while recombinant
hybrids are less fit on average, some gene combinations may be fitter than the
parents, even in the parental environment. Fisher's model does predict heterosis
in diploid F1s, asymmetric incompatibility in reciprocal backcrosses, and (when
dominance is included) Haldane's Rule. However, heterosis arises only when traits
are additive, whereas the latter two patterns require dominance. Moreover, because
adaptation is via substitutions of small effect, Fisher's model does not generate
the strong effects of single chromosome regions often observed in species crosses.
acknowledgement: This work was supported by the Darwin Trust of Edinburgh and by grant GR3/11635 from the Natural Environment Research
Council. I would like to thank Loren Rieseberg, Allen Orr, Michael Turelli, and
an anonymous referee for their helpful comments
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The role of hybridization in evolution. Molecular Ecology.
2001;10(3):551-568. doi:10.1046/j.1365-294X.2001.01216.x
apa: Barton, N. H. (2001). The role of hybridization in evolution. Molecular
Ecology. Wiley-Blackwell. https://doi.org/10.1046/j.1365-294X.2001.01216.x
chicago: Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular
Ecology. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.1365-294X.2001.01216.x.
ieee: N. H. Barton, “The role of hybridization in evolution,” Molecular Ecology,
vol. 10, no. 3. Wiley-Blackwell, pp. 551–568, 2001.
ista: Barton NH. 2001. The role of hybridization in evolution. Molecular Ecology.
10(3), 551–568.
mla: Barton, Nicholas H. “The Role of Hybridization in Evolution.” Molecular
Ecology, vol. 10, no. 3, Wiley-Blackwell, 2001, pp. 551–68, doi:10.1046/j.1365-294X.2001.01216.x.
short: N.H. Barton, Molecular Ecology 10 (2001) 551–568.
date_created: 2018-12-11T12:07:56Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-10T11:45:07Z
day: '01'
doi: 10.1046/j.1365-294X.2001.01216.x
extern: '1'
external_id:
pmid:
- '11298968'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 551 - 568
pmid: 1
publication: Molecular Ecology
publication_identifier:
issn:
- 962-1083
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1824'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of hybridization in evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2001'
...
---
_id: '4265'
abstract:
- lang: eng
text: The reasons that sex and recombination are so widespread remain elusive. One
popular hypothesis is that sex and recombination promote adaptation to a changing
environment. The strongest evidence that increased recombination may evolve because
recombination promotes adaptation comes from artificially selected populations.
Recombination rates have been found to increase as a correlated response to selection
on traits unrelated to recombination in several artificial selection experiments
and in a comparison of domesticated and nondomesticated mammals. There are, however,
several alternative explanations for the increase in recombination in such populations,
including two different evolutionary explanations. The first is that the form
of selection is epistatic, generating linkage disequilibria among selected loci,
which can indirectly favor modifier alleles that increase recombination. The second
is that random genetic drift in selected populations tends to generate disequilibria
such that beneficial alleles are often found in different individuals; modifier
alleles that increase recombination can bring together such favorable alleles
and thus may be found in individuals with greater fitness. In this paper, we compare
the evolutionary forces acting on recombination in finite populations subject
to strong selection, To our surprise, we found that drift accounted for the majority
of selection for increased recombination observed in simulations of small to moderately
large populations, suggesting that, unless selected populations are large, epistasis
plays a secondary role in the evolution of recombination.
acknowledgement: "We are grateful to P. Awadalla, T. Lenormand, A. Peters, S. West,
M. Whitlock, and two anonymous reviewers for helpful comments on the manuscript.
Funding was provided by the Natural Sciences and Engineering Research Council\r\n(Canada)
to SPO, the Centre National de la Recherche Scientifique (France) to SPO, the Darwin
Trust of Edinburgh to\r\nNHB, and the BBSRC (U.K.) to NHB. "
article_processing_charge: No
article_type: original
author:
- first_name: Sarah
full_name: Otto, Sarah
last_name: Otto
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Otto S, Barton NH. Selection for recombination in small populations. Evolution;
International Journal of Organic Evolution. 2001;55(10):1921-1931. doi:10.1111/j.0014-3820.2001.tb01310.x
apa: Otto, S., & Barton, N. H. (2001). Selection for recombination in small
populations. Evolution; International Journal of Organic Evolution. Wiley-Blackwell.
https://doi.org/10.1111/j.0014-3820.2001.tb01310.x
chicago: Otto, Sarah, and Nicholas H Barton. “Selection for Recombination in Small
Populations.” Evolution; International Journal of Organic Evolution. Wiley-Blackwell,
2001. https://doi.org/10.1111/j.0014-3820.2001.tb01310.x.
ieee: S. Otto and N. H. Barton, “Selection for recombination in small populations,”
Evolution; International Journal of Organic Evolution, vol. 55, no. 10.
Wiley-Blackwell, pp. 1921–1931, 2001.
ista: Otto S, Barton NH. 2001. Selection for recombination in small populations.
Evolution; International Journal of Organic Evolution. 55(10), 1921–1931.
mla: Otto, Sarah, and Nicholas H. Barton. “Selection for Recombination in Small
Populations.” Evolution; International Journal of Organic Evolution, vol.
55, no. 10, Wiley-Blackwell, 2001, pp. 1921–31, doi:10.1111/j.0014-3820.2001.tb01310.x.
short: S. Otto, N.H. Barton, Evolution; International Journal of Organic Evolution
55 (2001) 1921–1931.
date_created: 2018-12-11T12:07:56Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-05-10T12:12:32Z
day: '01'
doi: 10.1111/j.0014-3820.2001.tb01310.x
extern: '1'
external_id:
pmid:
- '11761054'
intvolume: ' 55'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 1921 - 1931
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1827'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selection for recombination in small populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2001'
...
---
_id: '4229'
abstract:
- lang: eng
text: Bacteriophage of the family Leviviridae have played an important role in molecular
biology where representative species, such as Qβ and MS2, have been studied as
model systems for replication, translation, and the role of secondary structure
in gene regulation. Using nucleotide sequences from the coat and replicase genes
we present the first statistical estimate of phylogeny for the family Leviviridae
using maximum-likelihood and Bayesian estimation. Our analyses reveal that the
coliphage species are a monophyletic group consisting of two clades representing
the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from
its common ancestor with the coliphage prior to the ancient split between these
genera and their subsequent diversification. Differences in genome size, gene
composition, and gene expression are shown with a high probability to have changed
along the lineage leading to the Allolevivirus through gene expansion. The change
in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes
that led to their current genome organization and gene expression.
acknowledgement: "We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves,
and Bret Larget for helpful comments and\r\nsuggestions. This work was supported
by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to
J.P.H."
article_processing_charge: No
article_type: original
author:
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
citation:
ama: Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity
of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular
Evolution. 2001;52(2):117-128. doi:10.1007/s002390010140
apa: Bollback, J. P., & Huelsenbeck, J. (2001). Phylogeny, genome evolution,
and host specificity of single-stranded RNA bacteriophage (Family Leviviridae).
Journal of Molecular Evolution. Springer. https://doi.org/10.1007/s002390010140
chicago: Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution,
and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).”
Journal of Molecular Evolution. Springer, 2001. https://doi.org/10.1007/s002390010140.
ieee: J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host
specificity of single-stranded RNA bacteriophage (Family Leviviridae),” Journal
of Molecular Evolution, vol. 52, no. 2. Springer, pp. 117–128, 2001.
ista: Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity
of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular
Evolution. 52(2), 117–128.
mla: Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution,
and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).”
Journal of Molecular Evolution, vol. 52, no. 2, Springer, 2001, pp. 117–28,
doi:10.1007/s002390010140.
short: J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128.
date_created: 2018-12-11T12:07:43Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-10T12:23:49Z
day: '01'
doi: 10.1007/s002390010140
extern: '1'
external_id:
pmid:
- '11231891'
intvolume: ' 52'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 117 - 128
pmid: 1
publication: Journal of Molecular Evolution
publication_identifier:
issn:
- 0022-2844
publication_status: published
publisher: Springer
publist_id: '1886'
quality_controlled: '1'
status: public
title: Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage
(Family Leviviridae)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '2001'
...
---
_id: '4264'
abstract:
- lang: eng
text: The study of speciation has become one of the most active areas of evolutionary
biology, and substantial progress has been made in documenting and understanding
phenomena ranging from sympatric speciation and reinforcement to the evolutionary
genetics of postzygotic isolation. This progress has been driven largely by empirical
results, and most useful theoretical work has concentrated on making sense of
empirical patterns. Given the complexity of speciation, mathematical theory is
subordinate to verbal theory and generalizations about data. Nevertheless, mathematical
theory can provide a useful classification of verbal theories; can help determine
the biological plausibility of verbal theories; can determine whether alternative
mechanisms of speciation are consistent with empirical patterns; and can occasionally
provide predictions that go beyond empirical generalizations. We discuss recent
examples of progress in each of these areas.
acknowledgement: 'We thank D. Bolnick, B. Fitzpatrick, S. Gavrilets, R. Haygood, C.D.
Jones, M. Kirkpatrick, A. Kondrashov, J.B. Mullet, S.V. Nuzhdin, H.A. Orr, T.D.
Price, T. Prout, D.W. Schemske, D. Schluter, M.R. Servedio and P.S. Ward for discussion
and comments. Some of these reviewers disagree with our conclusions. This work was
supported by US National Science Foundation grants DEB 9527808 and DEB 0089716 to
MT, grants from the Darwin Trust of Edinburgh and the Biotechnology and Biological
Sciences Research Council (GRJ/76057, GR/H/09928) to NHB, and National Institutes
of Health grant R01 GM58260 to JAC. '
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
citation:
ama: Turelli M, Barton NH, Coyne J. Theory and speciation. Trends in Ecology
and Evolution. 2001;16(7):330-343. doi:10.1016/S0169-5347(01)02177-2
apa: Turelli, M., Barton, N. H., & Coyne, J. (2001). Theory and speciation.
Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/S0169-5347(01)02177-2
chicago: Turelli, Michael, Nicholas H Barton, and Jerry Coyne. “Theory and Speciation.”
Trends in Ecology and Evolution. Cell Press, 2001. https://doi.org/10.1016/S0169-5347(01)02177-2.
ieee: M. Turelli, N. H. Barton, and J. Coyne, “Theory and speciation,” Trends
in Ecology and Evolution, vol. 16, no. 7. Cell Press, pp. 330–343, 2001.
ista: Turelli M, Barton NH, Coyne J. 2001. Theory and speciation. Trends in Ecology
and Evolution. 16(7), 330–343.
mla: Turelli, Michael, et al. “Theory and Speciation.” Trends in Ecology and
Evolution, vol. 16, no. 7, Cell Press, 2001, pp. 330–43, doi:10.1016/S0169-5347(01)02177-2.
short: M. Turelli, N.H. Barton, J. Coyne, Trends in Ecology and Evolution 16 (2001)
330–343.
date_created: 2018-12-11T12:07:55Z
date_published: 2001-07-01T00:00:00Z
date_updated: 2023-05-10T12:16:55Z
day: '01'
doi: 10.1016/S0169-5347(01)02177-2
extern: '1'
external_id:
pmid:
- '11403865'
intvolume: ' 16'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 330 - 343
pmid: 1
publication: Trends in Ecology and Evolution
publication_identifier:
issn:
- 0169-5347
publication_status: published
publisher: Cell Press
publist_id: '1828'
quality_controlled: '1'
status: public
title: Theory and speciation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2001'
...
---
_id: '4267'
abstract:
- lang: eng
text: The flow of genes from the dense and well-adapted centre of a species' distribution
interferes with adaptation to marginal environments, and may sharply limit a species'
range. Deterministic models of a linear habitat suggest that populations could
in principle adapt to very steep environmental gradients, by increasing their
genetic variability. However, random fluctuations in sparse populations reduce
this variance, and may be crucial in limiting the species' range.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Adaptation at the edge of a species’ range. In: Integrating
Ecology and Evolution in a Spatial Context. Cambridge University Press; 2001:365-392.'
apa: Barton, N. H. (2001). Adaptation at the edge of a species’ range. In Integrating
ecology and evolution in a spatial context (pp. 365–392). Cambridge University
Press.
chicago: Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” In Integrating
Ecology and Evolution in a Spatial Context, 365–92. Cambridge University Press,
2001.
ieee: N. H. Barton, “Adaptation at the edge of a species’ range,” in Integrating
ecology and evolution in a spatial context, Cambridge University Press, 2001,
pp. 365–392.
ista: 'Barton NH. 2001.Adaptation at the edge of a species’ range. In: Integrating
ecology and evolution in a spatial context. , 365–392.'
mla: Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” Integrating
Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001,
pp. 365–92.
short: N.H. Barton, in:, Integrating Ecology and Evolution in a Spatial Context,
Cambridge University Press, 2001, pp. 365–392.
date_created: 2018-12-11T12:07:57Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-10T11:59:06Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/us/academic/subjects/life-sciences/ecology-and-conservation/integrating-ecology-and-evolution-spatial-context-14th-special-symposium-british-ecological-society?format=HB&isbn=9780521840002
month: '08'
oa_version: None
page: 365 - 392
publication: Integrating ecology and evolution in a spatial context
publication_identifier:
isbn:
- '9780521840002'
publication_status: published
publisher: Cambridge University Press
publist_id: '1825'
quality_controlled: '1'
status: public
title: Adaptation at the edge of a species' range
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4002'
abstract:
- lang: eng
text: Shape deformation refers to the continuous change of one geometric object
to another. We develop a software tool for planning, analyzing and visualizing
deformations between two shapes in R-2. The deformation is generated automatically
without any user intervention or specification of feature correspondences. A unique
property of the tool is the explicit availability of a two-dimensional shape space,
which can be used for designing the deformation either automatically by following
constraints and objectives or manually by drawing deformation paths.
acknowledgement: NSF under grants CCR-96-19542 and CCR-97-12088.
article_processing_charge: No
article_type: original
author:
- first_name: Siu
full_name: Cheng, Siu
last_name: Cheng
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
- first_name: Ka
full_name: Lam, Ka
last_name: Lam
citation:
ama: 'Cheng S, Edelsbrunner H, Fu P, Lam K. Design and analysis of planar shape
deformation. Computational Geometry: Theory and Applications. 2001;19(2-3):205-218.
doi:10.1016/S0925-7721(01)00020-7'
apa: 'Cheng, S., Edelsbrunner, H., Fu, P., & Lam, K. (2001). Design and analysis
of planar shape deformation. Computational Geometry: Theory and Applications.
Elsevier. https://doi.org/10.1016/S0925-7721(01)00020-7'
chicago: 'Cheng, Siu, Herbert Edelsbrunner, Ping Fu, and Ka Lam. “Design and Analysis
of Planar Shape Deformation.” Computational Geometry: Theory and Applications.
Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00020-7.'
ieee: 'S. Cheng, H. Edelsbrunner, P. Fu, and K. Lam, “Design and analysis of planar
shape deformation,” Computational Geometry: Theory and Applications, vol.
19, no. 2–3. Elsevier, pp. 205–218, 2001.'
ista: 'Cheng S, Edelsbrunner H, Fu P, Lam K. 2001. Design and analysis of planar
shape deformation. Computational Geometry: Theory and Applications. 19(2–3), 205–218.'
mla: 'Cheng, Siu, et al. “Design and Analysis of Planar Shape Deformation.” Computational
Geometry: Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 205–18,
doi:10.1016/S0925-7721(01)00020-7.'
short: 'S. Cheng, H. Edelsbrunner, P. Fu, K. Lam, Computational Geometry: Theory
and Applications 19 (2001) 205–218.'
date_created: 2018-12-11T12:06:22Z
date_published: 2001-07-01T00:00:00Z
date_updated: 2023-05-10T14:21:31Z
day: '01'
doi: 10.1016/S0925-7721(01)00020-7
extern: '1'
intvolume: ' 19'
issue: 2-3
language:
- iso: eng
month: '07'
oa_version: None
page: 205 - 218
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2124'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Design and analysis of planar shape deformation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '2001'
...
---
_id: '4001'
abstract:
- lang: eng
text: 'The construction of shape spaces is studied from a mathematical and a computational
viewpoint. A program is outlined reducing the problem to four tasks: the representation
of geometry, the canonical deformation of geometry, the measuring of distance
in shape space, and the selection of base shapes. The technical part of this paper
focuses on the second task: the specification of a deformation mixing two or more
shapes in continuously changing proportions. (C) 2001 Elsevier Science B.V All
rights reserved.'
acknowledgement: National Science Foundation under grants CCR-96-19542 and CCR-97-12088,
and by the Army Research Office under grant DAAG55-98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Ho
full_name: Cheng, Ho
last_name: Cheng
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
citation:
ama: 'Cheng H, Edelsbrunner H, Fu P. Shape space from deformation. Computational
Geometry: Theory and Applications. 2001;19(2-3):191-204. doi:10.1016/S0925-7721(01)00021-9'
apa: 'Cheng, H., Edelsbrunner, H., & Fu, P. (2001). Shape space from deformation.
Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(01)00021-9'
chicago: 'Cheng, Ho, Herbert Edelsbrunner, and Ping Fu. “Shape Space from Deformation.”
Computational Geometry: Theory and Applications. Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00021-9.'
ieee: 'H. Cheng, H. Edelsbrunner, and P. Fu, “Shape space from deformation,” Computational
Geometry: Theory and Applications, vol. 19, no. 2–3. Elsevier, pp. 191–204,
2001.'
ista: 'Cheng H, Edelsbrunner H, Fu P. 2001. Shape space from deformation. Computational
Geometry: Theory and Applications. 19(2–3), 191–204.'
mla: 'Cheng, Ho, et al. “Shape Space from Deformation.” Computational Geometry:
Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 191–204, doi:10.1016/S0925-7721(01)00021-9.'
short: 'H. Cheng, H. Edelsbrunner, P. Fu, Computational Geometry: Theory and Applications
19 (2001) 191–204.'
date_created: 2018-12-11T12:06:22Z
date_published: 2001-07-01T00:00:00Z
date_updated: 2023-05-10T12:57:14Z
day: '01'
doi: 10.1016/S0925-7721(01)00021-9
extern: '1'
intvolume: ' 19'
issue: 2-3
language:
- iso: eng
month: '07'
oa_version: None
page: 191 - 204
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2123'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shape space from deformation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '2001'
...
---
_id: '4005'
abstract:
- lang: eng
text: This paper describes an algorithm for maintaining an approximating triangulation
of a deforming surface in R-3. The triangulation adapts dynamically to changing
shape, curvature, and topology of the surface.
article_processing_charge: No
author:
- first_name: Ho
full_name: Cheng, Ho
last_name: Cheng
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Sullivan, John
last_name: Sullivan
citation:
ama: 'Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. In:
Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms.
SIAM; 2001:47-56.'
apa: 'Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin
triangulation. In Proceedings of the 12th annual ACM-SIAM symposium on Discrete
algorithms (pp. 47–56). Washington, DC, USA : SIAM.'
chicago: Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic
Skin Triangulation.” In Proceedings of the 12th Annual ACM-SIAM Symposium on
Discrete Algorithms, 47–56. SIAM, 2001.
ieee: H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,”
in Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms,
Washington, DC, USA , 2001, pp. 47–56.
ista: 'Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation.
Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms. SODA:
Symposium on Discrete Algorithms, 47–56.'
mla: Cheng, Ho, et al. “Dynamic Skin Triangulation.” Proceedings of the 12th
Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56.
short: H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, in:, Proceedings of the 12th
Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56.
conference:
end_date: 2001-01-09
location: 'Washington, DC, USA '
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2001-01-07
date_created: 2018-12-11T12:06:23Z
date_published: 2001-01-09T00:00:00Z
date_updated: 2023-05-10T12:35:44Z
day: '09'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.5555/365411.365418
month: '01'
oa_version: None
page: 47 - 56
publication: Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms
publication_identifier:
isbn:
- '9780898714906'
publication_status: published
publisher: SIAM
publist_id: '2120'
quality_controlled: '1'
status: public
title: Dynamic skin triangulation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '4007'
abstract:
- lang: eng
text: 'This paper describes an algorithm for maintaining an approximating triangulation
of a deforming surface in R 3 . The surface is the envelope of an infinite family
of spheres defined and controlled by a finite collection of weighted points. The
triangulation adapts dynamically to changing shape, curvature, and topology of
the surface. '
acknowledgement: NSF under grant DMS- 98-73945, ARO under grant DAAG55-98-1-0177,
NSF under grants CCR-96- 19542 and CCR-97-12088.
article_processing_charge: No
article_type: original
author:
- first_name: Ho
full_name: Cheng, Ho
last_name: Cheng
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Sullivan, John
last_name: Sullivan
citation:
ama: Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. Discrete
& Computational Geometry. 2001;25(4):525-568. doi:10.1007/s00454-001-0007-1
apa: Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin
triangulation. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0007-1
chicago: Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic
Skin Triangulation.” Discrete & Computational Geometry. Springer, 2001.
https://doi.org/10.1007/s00454-001-0007-1.
ieee: H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,”
Discrete & Computational Geometry, vol. 25, no. 4. Springer, pp. 525–568,
2001.
ista: Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation.
Discrete & Computational Geometry. 25(4), 525–568.
mla: Cheng, Ho, et al. “Dynamic Skin Triangulation.” Discrete & Computational
Geometry, vol. 25, no. 4, Springer, 2001, pp. 525–68, doi:10.1007/s00454-001-0007-1.
short: H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, Discrete & Computational
Geometry 25 (2001) 525–568.
date_created: 2018-12-11T12:06:24Z
date_published: 2001-04-04T00:00:00Z
date_updated: 2023-05-10T12:45:59Z
day: '04'
doi: 10.1007/s00454-001-0007-1
extern: '1'
intvolume: ' 25'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 525 - 568
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2122'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic skin triangulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 25
year: '2001'
...
---
_id: '4006'
abstract:
- lang: eng
text: The 180 models collected in this paper are produced by sampling and wrapping
point sets on tubes. The surfaces are represented as triangulated 2-manifolds
and available as st1-files from the author's web site at www.cs.duke.edu/similar
toedels. Each tube is obtained by thickening a circle or a smooth torus knot,
and for some we use the degrees of freedom in the thickening process to encode
meaningful information, such as curvature or torsion.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. 180 wrapped tubes. Journal of Universal Computer Science.
2001;7(5):379-399. doi:10.3217/jucs-007-05-0379
apa: Edelsbrunner, H. (2001). 180 wrapped tubes. Journal of Universal Computer
Science. Springer. https://doi.org/10.3217/jucs-007-05-0379
chicago: Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer
Science. Springer, 2001. https://doi.org/10.3217/jucs-007-05-0379.
ieee: H. Edelsbrunner, “180 wrapped tubes,” Journal of Universal Computer Science,
vol. 7, no. 5. Springer, pp. 379–399, 2001.
ista: Edelsbrunner H. 2001. 180 wrapped tubes. Journal of Universal Computer Science.
7(5), 379–399.
mla: Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer
Science, vol. 7, no. 5, Springer, 2001, pp. 379–99, doi:10.3217/jucs-007-05-0379.
short: H. Edelsbrunner, Journal of Universal Computer Science 7 (2001) 379–399.
date_created: 2018-12-11T12:06:24Z
date_published: 2001-05-28T00:00:00Z
date_updated: 2023-05-10T12:39:54Z
day: '28'
doi: 10.3217/jucs-007-05-0379
extern: '1'
intvolume: ' 7'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 379 - 399
publication: Journal of Universal Computer Science
publication_identifier:
issn:
- 0948-695X
publication_status: published
publisher: Springer
publist_id: '2121'
quality_controlled: '1'
status: public
title: 180 wrapped tubes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '2001'
...
---
_id: '3928'
abstract:
- lang: eng
text: Regulated adhesion of leukocytes to the extracellular matrix is essential
for transmigration of blood vessels and subsequent migration into the stroma of
inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion
of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)-
and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion
to and migration on extracellular matrix molecules of the endothelial cell basement
membrane and subjacent interstitial matrix. Mouse wild type and beta(2)-integrin
null PMN and the progranulocytic cell line 32DC13 were employed in in vitro adhesion
and migration assays using extracellular matrix molecules expressed at sites of
extravasation in vivo, in particular the endothelial cell laminins 8 and 10. Wild
type and beta(2)-integrin null PMN showed the same pattern of ECM binding, indicating
that beta(2)-integrins do not mediate specific adhesion of PMN to the extracellular
matrix molecules tested; binding was observed to the interstitial matrix molecules,
fibronectin and vitronectin, via integrins alpha(5)beta(1) and alpha(v)beta(3),
respectively; to laminin 10 via alpha(6)beta(1); but not to laminins 1, 2, and
8, collagen type I and IV, perlecan, or tenascin-C. PMN binding to laminins 1,
2, and 8 could not be induced despite surface expression of functionally active
integrin alpha(6)beta(1), a major laminin receptor, demonstrating that expression
of alpha(6)beta(1) alone is insufficient for ligand binding and suggesting the
involvement of accessory factors. Nevertheless, laminins 1, 8, and 10 supported
PMN migration, indicating that differential cellular signaling via laminins is
independent of the extent of adhesion. The data demonstrate that adhesive and
nonadhesive interactions with components of the endothelial cell basement membrane
and subjacent interstitium play decisive roles in controlling PMN movement into
sites of inflammation and illustrate that beta(2)-integrins are not essential
for such interactions.
acknowledgement: We thank Dr. T. Winkler for carrying out flow cytometry analysis,
Dr. Simon Goodman for providing cyclic RGD peptides and helpful discussions, and
Stefanie Karosi and Thomas Samson for critical review of the manuscript. This work
would not have been possible without the expert technical assistance of Friederike
Pausch.
article_processing_charge: No
article_type: original
author:
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Rupert
full_name: Hallmann, Rupert
last_name: Hallmann
- first_name: Olaf
full_name: Wendler, Olaf
last_name: Wendler
- first_name: Karin
full_name: Scharffetter Kochanek, Karin
last_name: Scharffetter Kochanek
- first_name: Lydia
full_name: Sorokin, Lydia
last_name: Sorokin
citation:
ama: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. Cell adhesion
and migration properties of β2-integrin negative polymorphonuclear granulocytes
on defined extracellular matrix molecules. Relevance for leukocyte extravasation.
Journal of Biological Chemistry. 2001;276(22):18878-18887. doi:10.1074/jbc.M010898200
apa: Sixt, M. K., Hallmann, R., Wendler, O., Scharffetter Kochanek, K., & Sorokin,
L. (2001). Cell adhesion and migration properties of β2-integrin negative polymorphonuclear
granulocytes on defined extracellular matrix molecules. Relevance for leukocyte
extravasation. Journal of Biological Chemistry. American Society for Biochemistry
and Molecular Biology. https://doi.org/10.1074/jbc.M010898200
chicago: Sixt, Michael K, Rupert Hallmann, Olaf Wendler, Karin Scharffetter Kochanek,
and Lydia Sorokin. “Cell Adhesion and Migration Properties of Β2-Integrin Negative
Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance
for Leukocyte Extravasation.” Journal of Biological Chemistry. American
Society for Biochemistry and Molecular Biology, 2001. https://doi.org/10.1074/jbc.M010898200.
ieee: M. K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, and L. Sorokin,
“Cell adhesion and migration properties of β2-integrin negative polymorphonuclear
granulocytes on defined extracellular matrix molecules. Relevance for leukocyte
extravasation,” Journal of Biological Chemistry, vol. 276, no. 22. American
Society for Biochemistry and Molecular Biology, pp. 18878–18887, 2001.
ista: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. 2001.
Cell adhesion and migration properties of β2-integrin negative polymorphonuclear
granulocytes on defined extracellular matrix molecules. Relevance for leukocyte
extravasation. Journal of Biological Chemistry. 276(22), 18878–18887.
mla: Sixt, Michael K., et al. “Cell Adhesion and Migration Properties of Β2-Integrin
Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules.
Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry,
vol. 276, no. 22, American Society for Biochemistry and Molecular Biology, 2001,
pp. 18878–87, doi:10.1074/jbc.M010898200.
short: M.K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, L. Sorokin,
Journal of Biological Chemistry 276 (2001) 18878–18887.
date_created: 2018-12-11T12:05:56Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-11T12:54:06Z
day: '01'
doi: 10.1074/jbc.M010898200
extern: '1'
external_id:
pmid:
- '11278780'
intvolume: ' 276'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819670134?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 18878 - 18887
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '2199'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell adhesion and migration properties of β2-integrin negative polymorphonuclear
granulocytes on defined extracellular matrix molecules. Relevance for leukocyte
extravasation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 276
year: '2001'
...
---
_id: '3927'
abstract:
- lang: eng
text: TNF-alpha has been clearly identified as central mediator of T cell activation-induced
acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury
depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We
show in this report that the hepatic TNFRs are not transcriptionally regulated,
but are regulated by receptor shedding. TNF directly mediates hepatocellular death
by activation of TNFR1 but also induces the expression of inflammatory proteins,
such as cytokines and adhesion molecules. Here we provide evidence that resistance
of TNFR1(-/-) and TNFR2(-/-) mice against Con A hepatitis is not due to an impaired
production of the central mediators TNF and IFN-gamma. Con A injection results
in a massive induction of ICAM-1, VCAM-1, and E-selectin in the liver. Lack of
either one of both TNFRs did not change adhesion molecule expression in the livers
of Con A-treated mice, presumably reflecting the fact that other endothelial cell-activating
cytokines up-regulated adhesion molecule expression. However, treatment of TNFR1(-/-)
and TNFR2(-/-) mice with murine rTNF revealed a predominant role for TNFR1 for
the induction of hepatic adhesion molecule expression. Pretreatment with blocking
Abs against E- and P-selectin or of ICAM(-/-) mice with anti-VCAM-1 Abs failed
to prevent Con A hepatitis, although accumulation of the critical cell population,
i.e., CD4(+) T cells was significantly inhibited. Hence, up-regulation of adhesion
molecules during acute hepatitis unlikely contributes to organ injury but rather
represents a defense mechanism.
acknowledgement: We thank Dr. H. Bluethmann (F. Hoffmann-LaRoche AG, Basle, Switzerland)
for kindly providing us TNFR knockout mice. We are indebted to Dr. G. R. Adolf (Bender
& Co Vienna, Austria) for providing recombinant murine TNF. We are also indebted
to Dr. D. Vestweber for providing anti-P-selectin mAb (23). We thank Dr. W. Neuhuber
(Institute of Anatomy, University of Erlangen-NÜrnberg, Erlangen, Germany) for
experimental support regarding confocal laser scanning microscopy. The perfect technical
assistance of Andrea Agli is gratefully acknowledged.
article_processing_charge: No
article_type: original
author:
- first_name: Dominik
full_name: Wolf, Dominik
last_name: Wolf
- first_name: Rupert
full_name: Hallmann, Rupert
last_name: Hallmann
- first_name: Gabriele
full_name: Sass, Gabriele
last_name: Sass
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Sabine
full_name: Küsters, Sabine
last_name: Küsters
- first_name: Bastian
full_name: Fregien, Bastian
last_name: Fregien
- first_name: Christian
full_name: Trautwein, Christian
last_name: Trautwein
- first_name: Gisa
full_name: Tiegs, Gisa
last_name: Tiegs
citation:
ama: Wolf D, Hallmann R, Sass G, et al. TNF-α-induced expression of adhesion molecules
in the liver is under the control of TNFR1--relevance for concanavalin A-induced
hepatitis. Journal of Immunology. 2001;166(2):1300-1307. doi:10.4049/jimmunol.166.2.1300
apa: Wolf, D., Hallmann, R., Sass, G., Sixt, M. K., Küsters, S., Fregien, B., …
Tiegs, G. (2001). TNF-α-induced expression of adhesion molecules in the liver
is under the control of TNFR1--relevance for concanavalin A-induced hepatitis.
Journal of Immunology. American Association of Immunologists. https://doi.org/10.4049/jimmunol.166.2.1300
chicago: Wolf, Dominik, Rupert Hallmann, Gabriele Sass, Michael K Sixt, Sabine Küsters,
Bastian Fregien, Christian Trautwein, and Gisa Tiegs. “TNF-α-Induced Expression
of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for
Concanavalin A-Induced Hepatitis.” Journal of Immunology. American Association
of Immunologists, 2001. https://doi.org/10.4049/jimmunol.166.2.1300.
ieee: D. Wolf et al., “TNF-α-induced expression of adhesion molecules in
the liver is under the control of TNFR1--relevance for concanavalin A-induced
hepatitis,” Journal of Immunology, vol. 166, no. 2. American Association
of Immunologists, pp. 1300–1307, 2001.
ista: Wolf D, Hallmann R, Sass G, Sixt MK, Küsters S, Fregien B, Trautwein C, Tiegs
G. 2001. TNF-α-induced expression of adhesion molecules in the liver is under
the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal
of Immunology. 166(2), 1300–1307.
mla: Wolf, Dominik, et al. “TNF-α-Induced Expression of Adhesion Molecules in the
Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.”
Journal of Immunology, vol. 166, no. 2, American Association of Immunologists,
2001, pp. 1300–07, doi:10.4049/jimmunol.166.2.1300.
short: D. Wolf, R. Hallmann, G. Sass, M.K. Sixt, S. Küsters, B. Fregien, C. Trautwein,
G. Tiegs, Journal of Immunology 166 (2001) 1300–1307.
date_created: 2018-12-11T12:05:56Z
date_published: 2001-01-15T00:00:00Z
date_updated: 2023-05-11T13:37:29Z
day: '15'
doi: 10.4049/jimmunol.166.2.1300
extern: '1'
external_id:
pmid:
- '11145713'
intvolume: ' 166'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.jimmunol.org/content/166/2/1300.long
month: '01'
oa: 1
oa_version: None
page: 1300 - 1307
pmid: 1
publication: Journal of Immunology
publication_identifier:
issn:
- 0022-1767
publication_status: published
publisher: American Association of Immunologists
publist_id: '2200'
quality_controlled: '1'
status: public
title: TNF-α-induced expression of adhesion molecules in the liver is under the control
of TNFR1--relevance for concanavalin A-induced hepatitis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 166
year: '2001'
...
---
_id: '3930'
abstract:
- lang: eng
text: 'An active involvement of blood-brain barrier endothelial cell basement membranes
in development of inflammatory lesions in the central nervous system (CNS) has
not been considered to date. Here we investigated the molecular composition and
possible function of the extracellular matrix encountered by extravasating T lymphocytes
during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes
contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their
expression was influenced by proinflammatory cytokines or angiostatic agents.
T cells emigrating into the CNS during EAE encountered two biochemically distinct
basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal
(containing laminins 1 and 2) basement membranes. However, inflammatory cuffs
occurred exclusively around endothelial basement membranes containing laminin
8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro
assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and
10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of
integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus
a high turnover of laminin 8 at these sites, suggested two possible roles for
laminin 8 in the endothelial basement membrane: one at the level of the endothelial
cells resulting in reduced adhesion and, thereby, increased penetrability of the
monolayer; and secondly at the level of the T cells providing direct signals to
the transmigrating cells.'
acknowledgement: The authors thank Stefanie Karosi for careful and critical reading
of the manuscript and Monika Bruckner for expert technical assistance. We are particularly
grateful to Winfried Neuhuber for help with confocal microscopy and interpretation
of the data. This work was supported by Deutsche Forschungsgemeinschaft grants So285/1-3
and So285/1-4 to L.M. Sorokin.
article_processing_charge: No
article_type: original
author:
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Britta
full_name: Engelhardt, Britta
last_name: Engelhardt
- first_name: Friederike
full_name: Pausch, Friederike
last_name: Pausch
- first_name: Rupert
full_name: Hallmann, Rupert
last_name: Hallmann
- first_name: Olaf
full_name: Wendler, Olaf
last_name: Wendler
- first_name: Lydia
full_name: Sorokin, Lydia
last_name: Sorokin
citation:
ama: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial
cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment
across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal
of Cell Biology. 2001;153(5):933-946. doi:10.1083/jcb.153.5.933
apa: Sixt, M. K., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin,
L. (2001). Endothelial cell laminin isoforms, laminins 8 and 10, play decisive
roles in T cell recruitment across the blood-brain barrier in experimental autoimmune
encephalomyelitis. Journal of Cell Biology. Rockefeller University Press.
https://doi.org/10.1083/jcb.153.5.933
chicago: Sixt, Michael K, Britta Engelhardt, Friederike Pausch, Rupert Hallmann,
Olaf Wendler, and Lydia Sorokin. “Endothelial Cell Laminin Isoforms, Laminins
8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier
in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology.
Rockefeller University Press, 2001. https://doi.org/10.1083/jcb.153.5.933 .
ieee: M. K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, and L. Sorokin,
“Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in
T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis,”
Journal of Cell Biology, vol. 153, no. 5. Rockefeller University Press,
pp. 933–946, 2001.
ista: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. 2001. Endothelial
cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment
across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal
of Cell Biology. 153(5), 933–946.
mla: Sixt, Michael K., et al. “Endothelial Cell Laminin Isoforms, Laminins 8 and
10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in
Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology, vol.
153, no. 5, Rockefeller University Press, 2001, pp. 933–46, doi:10.1083/jcb.153.5.933 .
short: M.K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L. Sorokin,
Journal of Cell Biology 153 (2001) 933–946.
date_created: 2018-12-11T12:05:57Z
date_published: 2001-05-21T00:00:00Z
date_updated: 2023-05-11T12:19:36Z
day: '21'
doi: '10.1083/jcb.153.5.933 '
extern: '1'
external_id:
pmid:
- '11381080'
intvolume: ' 153'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174323/
month: '05'
oa: 1
oa_version: Published Version
page: 933 - 946
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '2198'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in
T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 153
year: '2001'
...
---
_id: '3622'
abstract:
- lang: eng
text: The extent of genetic variation in fitness and its components and genetic
variation's dependence on environmental conditions remain key issues in evolutionary
biology. We present measurements of genetic variation in preadult viability in
a laboratory-adapted population of Drosophila melanogaster, made at four different
densities. By crossing flies heterozygous for a wild-type chromosome and one of
two different balancers (TM1, TM2), we measure both heterozygous (TM1/+, TM2/+)
and homozygous (+/+) viability relative to a standard genotype (TM1/TM2). Forty
wild-type chromosomes were tested, of which 10 were chosen to be homozygous viable.
The mean numbers produced varied significantly between chromosome lines, with
an estimated between-line variance in loge numbers of 0.013. Relative viabilities
also varied significantly across chromosome lines, with a variance in loge homozygous
viability of 1.76 and of loge heterozygous viability of 0.165. The between-line
variance for numbers emerging increased with density, from 0.009 at lowest density
to 0.079 at highest. The genetic variance in relative viability increases with
density, but not significantly. Overall, the effects of different chromosomes
on relative viability were remarkably consistent across densities and across the
two heterozygous genotypes (TM1, TM2). The 10 lines that carried homozygous viable
wild-type chromosomes produced significantly more adults than the 30 lethal lines
at low density and significantly fewer adults at the highest density. Similarly,
there was a positive correlation between heterozygous viability and mean numbers
at low density, but a negative correlation at high density.
acknowledgement: We thank SERC and BBSRC for financial support and R.Miah, G. Geddes,
and E. Garcia for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Gardner, Michael
last_name: Gardner
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Linda
full_name: Patridge, Linda
last_name: Patridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Gardner M, Fowler K, Patridge L, Barton NH. Genetic variation for preadult
viability in Drosophila melanogaster. Evolution. 2001;55(8):1609-1620.
doi:10.1111/j.0014-3820.2001.tb00680.x
apa: Gardner, M., Fowler, K., Patridge, L., & Barton, N. H. (2001). Genetic
variation for preadult viability in Drosophila melanogaster. Evolution.
Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x
chicago: Gardner, Michael, Kevin Fowler, Linda Patridge, and Nicholas H Barton.
“Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution.
Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x.
ieee: M. Gardner, K. Fowler, L. Patridge, and N. H. Barton, “Genetic variation for
preadult viability in Drosophila melanogaster,” Evolution, vol. 55, no.
8. Wiley-Blackwell, pp. 1609–1620, 2001.
ista: Gardner M, Fowler K, Patridge L, Barton NH. 2001. Genetic variation for preadult
viability in Drosophila melanogaster. Evolution. 55(8), 1609–1620.
mla: Gardner, Michael, et al. “Genetic Variation for Preadult Viability in Drosophila
Melanogaster.” Evolution, vol. 55, no. 8, Wiley-Blackwell, 2001, pp. 1609–20,
doi:10.1111/j.0014-3820.2001.tb00680.x.
short: M. Gardner, K. Fowler, L. Patridge, N.H. Barton, Evolution 55 (2001) 1609–1620.
date_created: 2018-12-11T12:04:18Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-11T13:43:30Z
day: '01'
doi: 10.1111/j.0014-3820.2001.tb00680.x
extern: '1'
external_id:
pmid:
- '11580020'
intvolume: ' 55'
issue: '8'
language:
- iso: eng
main_file_link:
- url: http://www.jstor.org/stable/2680379
month: '08'
oa_version: None
page: 1609 - 1620
pmid: 1
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2761'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic variation for preadult viability in Drosophila melanogaster
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2001'
...
---
_id: '3596'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Mendel and mathematics. Trends in Genetics. 2001;17:420-420.
doi:10.1016/S0168-9525(01)02315-0
apa: Barton, N. H. (2001). Mendel and mathematics. Trends in Genetics. Elsevier.
https://doi.org/10.1016/S0168-9525(01)02315-0
chicago: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics.
Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02315-0.
ieee: N. H. Barton, “Mendel and mathematics,” Trends in Genetics, vol. 17.
Elsevier, pp. 420–420, 2001.
ista: Barton NH. 2001. Mendel and mathematics. Trends in Genetics. 17, 420–420.
mla: Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics, vol.
17, Elsevier, 2001, pp. 420–420, doi:10.1016/S0168-9525(01)02315-0.
short: N.H. Barton, Trends in Genetics 17 (2001) 420–420.
date_created: 2018-12-11T12:04:09Z
date_published: 2001-07-01T00:00:00Z
date_updated: 2023-05-11T13:50:32Z
day: '01'
doi: 10.1016/S0168-9525(01)02315-0
extern: '1'
intvolume: ' 17'
language:
- iso: eng
month: '07'
oa_version: None
page: 420 - 420
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9479
publication_status: published
publisher: Elsevier
publist_id: '2787'
quality_controlled: '1'
status: public
title: Mendel and mathematics
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '3546'
abstract:
- lang: eng
text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated
in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a
significantly stronger relationship among local (<140 <mu>m) pyramidal
neurons compared with distant (>300 mum) neurons during non-theta-associated
immobility and sleep but not during theta-associated running and walking. In contrast,
cross-correlation between local pyramidal cell-interneuron pairs was significantly
stronger than between distant pairs during theta oscillations but were similar
during non-theta-associated behaviors. We suggest that network state-dependent
functional clustering of neuronal activity emerges because of the differential
contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals
during theta and non-theta behaviors.
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001
apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G.
(2001). Behavior-dependent states of the hippocampal network affect functional
clustering of neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001
chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and
György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional
Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience,
2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001.
ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent
states of the hippocampal network affect functional clustering of neurons,” Journal
of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001.
ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 21(10).
mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network
Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol.
21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001.
short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal
of Neuroscience 21 (2001).
date_created: 2018-12-11T12:03:54Z
date_published: 2001-05-15T00:00:00Z
date_updated: 2023-05-12T09:47:39Z
day: '15'
doi: 10.1523/JNEUROSCI.21-10-j0003.2001
extern: '1'
external_id:
pmid:
- '11319243'
intvolume: ' 21'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/11319243/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2839'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavior-dependent states of the hippocampal network affect functional clustering
of neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3540'
abstract:
- lang: eng
text: What determines the firing rate of cortical neurons in the absence of external
sensory input or motor behavior, such as during sleep? Hero we report that, in
a familiar environment, the discharge frequency of simultaneously recorded individual
CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated
across sleep-wake-steep sequences. However, both measures were affected when new
sets of neurons were activated in a novel environment. Nevertheless, the grand
mean firing rate of the whole pyramidal cell population remained constant across
behavioral states and testing conditions. The findings suggest that long-term
firing patterns of single cells can be modified by experience. We hypothesize
that increased firing rates of recently used neurons are associated with a concomitant
decrease in the discharge activity of the remaining population, leaving the mean
excitability of the hippocampal network unaltered.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.),
and the Uehara Memorial Foundation (H.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of
hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398
apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G.
(2001). Firing rates of hippocampal neurons are preserved during subsequent sleep
episodes and modified by novel awake experience. PNAS. National Academy
of Sciences. https://doi.org/10.1073/pnas.161274398
chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent
Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National
Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398.
ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing
rates of hippocampal neurons are preserved during subsequent sleep episodes and
modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy
of Sciences, pp. 9386–9390, 2001.
ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates
of hippocampal neurons are preserved during subsequent sleep episodes and modified
by novel awake experience. PNAS. 98(16), 9386–9390.
mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during
Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS,
vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398.
short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98
(2001) 9386–9390.
date_created: 2018-12-11T12:03:52Z
date_published: 2001-07-31T00:00:00Z
date_updated: 2023-05-12T10:07:41Z
day: '31'
doi: 10.1073/pnas.161274398
extern: '1'
external_id:
pmid:
- '11470910'
intvolume: ' 98'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/
month: '07'
oa: 1
oa_version: Published Version
page: 9386 - 9390
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2846'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes
and modified by novel awake experience
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '3494'
abstract:
- lang: eng
text: 'Mutual synaptic interactions between GABAergic interneurons are thought to
be of critical importance for the generation of network oscillations and for temporal
encoding of information in the hippocampus. However, the functional properties
of synaptic transmission between hippocampal interneurons are largely unknown.
We have made paired recordings from basket cells (BCs) in the dentate gyrus of
rat hippocampal slices, followed by correlated light and electron microscopical
analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the
soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2
msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression
(PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression
during repetitive stimulation. Detailed passive cable model simulations based
on somatodendritic morphology and localization of synaptic contacts further indicated
that the conductance change at the postsynaptic site was even faster, decaying
with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed
that the decay time course of IPSCs at BC–BC synapses was approximately twofold
faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable.
To examine the consequences of the fast postsynaptic conductance change for the
generation of oscillatory activity, we developed a computational model of an interneuron
network. The model showed robust oscillations at frequencies >60 Hz if the
excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron
synapses may promote the generation of high-frequency oscillations observed in
the dentate gyrusin vivo. '
acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft
(SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B).
We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading
this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction
and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory
synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001
apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001).
Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001
chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M
Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron
Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001.
ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling
at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of
Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001.
ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at
inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
21(8), 2687–2698.
mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate
Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society
for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001.
short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience
21 (2001) 2687–2698.
date_created: 2018-12-11T12:03:37Z
date_published: 2001-04-15T00:00:00Z
date_updated: 2023-05-15T13:47:04Z
day: '15'
doi: 10.1523/JNEUROSCI.21-08-02687.2001
extern: '1'
external_id:
pmid:
- '11306622'
intvolume: ' 21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/
month: '04'
oa: 1
oa_version: Published Version
page: 2687 - 2698
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2893'
quality_controlled: '1'
status: public
title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3496'
abstract:
- lang: eng
text: 'The mossy fiber-CA3 pyramidal neuron synapse is a main component of the hippocampal
trisynaptic circuitry. Recent studies, however, suggested that inhibitory interneurons
are the major targets of the mossy fiber system. To study the regulation of mossy
fiber-interneuron excitation, we examined unitary and compound excitatory postsynaptic
currents in dentate gyrus basket cells, evoked by paired recording between granule
and basket cells or extracellular stimulation of mossy fiber collaterals. The
application of an associative high-frequency stimulation paradigm induced posttetanic
potentiation (PTP) followed by homosynaptic long-term potentiation (LTP). Analysis
of numbers of failures, coefficient of variation, and paired-pulse modulation
indicated that both PTP and LTP were expressed presynaptically. The Ca2+ chelator
1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) did not affect
PTP or LTP at a concentration of 10 mM but attenuated LTP at a concentration of
30 mM. Both forskolin, an adenylyl cyclase activator, and phorbolester diacetate,
a protein kinase C stimulator, lead to a long-lasting increase in excitatory postsynaptic
current amplitude. H-89, a protein kinase A inhibitor, and bisindolylmaleimide,
a protein kinase C antagonist, reduced PTP, whereas only bisindolylmaleimide reduced
LTP. These results may suggest a differential contribution of protein kinase A
and C pathways to mossy fiber-interneuron plasticity. Interneuron PTP and LTP
may provide mechanisms to maintain the balance between synaptic excitation of
interneurons and that of principal neurons in the dentate gyrus-CA3 network. '
acknowledgement: We thank Drs. J. Bischofberger and M. Martina for critically reading
an earlier version of the manuscript and A. Blomenkamp for excellent technical assistance.
Supported by the Deutsche Forschungsgemeinschaft Sonderforschungsbereich 505/C5
and Human Frontiers Science Program Organization Grant RG0017/98.
article_processing_charge: No
article_type: original
author:
- first_name: Henrik
full_name: Alle, Henrik
last_name: Alle
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
citation:
ama: Alle H, Jonas PM, Geiger J. PTP and LTP at a hippocampal mossy fiber-interneuron
synapse. PNAS. 2001;98(25):14708-14713. doi:10.1073/pnas.251610898
apa: Alle, H., Jonas, P. M., & Geiger, J. (2001). PTP and LTP at a hippocampal
mossy fiber-interneuron synapse. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.251610898
chicago: Alle, Henrik, Peter M Jonas, and Jörg Geiger. “PTP and LTP at a Hippocampal
Mossy Fiber-Interneuron Synapse.” PNAS. National Academy of Sciences, 2001.
https://doi.org/10.1073/pnas.251610898
.
ieee: H. Alle, P. M. Jonas, and J. Geiger, “PTP and LTP at a hippocampal mossy fiber-interneuron
synapse,” PNAS, vol. 98, no. 25. National Academy of Sciences, pp. 14708–14713,
2001.
ista: Alle H, Jonas PM, Geiger J. 2001. PTP and LTP at a hippocampal mossy fiber-interneuron
synapse. PNAS. 98(25), 14708–14713.
mla: Alle, Henrik, et al. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron
Synapse.” PNAS, vol. 98, no. 25, National Academy of Sciences, 2001, pp.
14708–13, doi:10.1073/pnas.251610898
.
short: H. Alle, P.M. Jonas, J. Geiger, PNAS 98 (2001) 14708–14713.
date_created: 2018-12-11T12:03:38Z
date_published: 2001-12-04T00:00:00Z
date_updated: 2023-05-15T11:08:08Z
day: '04'
doi: '10.1073/pnas.251610898 '
extern: '1'
external_id:
pmid:
- '11734656'
intvolume: ' 98'
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64746/
month: '12'
oa: 1
oa_version: None
page: 14708 - 14713
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2891'
quality_controlled: '1'
scopus_import: '1'
status: public
title: PTP and LTP at a hippocampal mossy fiber-interneuron synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '3495'
abstract:
- lang: eng
text: High Ca2+ permeability and its control by voltage-dependent Mg2+ block are
defining features of NMDA receptors. These features are lost if the principal
NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical
channel site at NR1 position 598. NR1(R) expression from a single allele in gene-targeted
NR1+/R mice is lethal soon after birth, precluding analysis of altered synaptic
functions later in life. We therefore employed the forebrain specific αCaMKII
promoter to drive tTA-mediated tetracyclin sensitive transcription of transgenes
for NR1(R) and for lacZ as reporter. Transgene expression was observed in cortex,
striatum, hippocampus, amygdala and olfactory bulb and was mosaic in all these
forebrain regions. It was highest in olfactory bulb granule cells, in most of
which Ca2+ permeability and voltage-dependent Mg2+ block of NMDA receptors were
reduced to different extents. This indicates significant impairment of NMDA receptor
function by NR1(R) in presence of the wild-type NR1 complement. Indeed, even though
NR1(R) mRNA constituted only 18% of the entire NR1 mRNA population in forebrain,
the transgenic mice died during adolescence unless transgene expression was suppressed
by doxycycline. Thus, glutamate receptor function can be altered in the mouse
by regulated NR1(R) transgene expression.
acknowledgement: 'This work was supported in part by grants from the 358 (1992) 36–41.Deutsche
Forschungsgemeinschaft (Bi 642 / 1-2) and the Volkswagen foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Jasna
full_name: Jerecic, Jasna
last_name: Jerecic
- first_name: Christian
full_name: Schulze, Christian
last_name: Schulze
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Rolf
full_name: Sprengel, Rolf
last_name: Sprengel
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
citation:
ama: Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. Impaired
NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive
NR1 (N598R) expression. Molecular Brain Research. 2001;94(1-2):96-104.
doi:10.1016/S0169-328X(01)00221-2
apa: Jerecic, J., Schulze, C., Jonas, P. M., Sprengel, R., Seeburg, P., & Bischofberger,
J. (2001). Impaired NMDA receptor function in mouse olfactory bulb neurons by
tetracycline-sensitive NR1 (N598R) expression. Molecular Brain Research.
Elsevier. https://doi.org/10.1016/S0169-328X(01)00221-2
chicago: Jerecic, Jasna, Christian Schulze, Peter M Jonas, Rolf Sprengel, Peter
Seeburg, and Joseph Bischofberger. “Impaired NMDA Receptor Function in Mouse Olfactory
Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” Molecular Brain
Research. Elsevier, 2001. https://doi.org/10.1016/S0169-328X(01)00221-2.
ieee: J. Jerecic, C. Schulze, P. M. Jonas, R. Sprengel, P. Seeburg, and J. Bischofberger,
“Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive
NR1 (N598R) expression,” Molecular Brain Research, vol. 94, no. 1–2. Elsevier,
pp. 96–104, 2001.
ista: Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. 2001.
Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive
NR1 (N598R) expression. Molecular Brain Research. 94(1–2), 96–104.
mla: Jerecic, Jasna, et al. “Impaired NMDA Receptor Function in Mouse Olfactory
Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” Molecular Brain
Research, vol. 94, no. 1–2, Elsevier, 2001, pp. 96–104, doi:10.1016/S0169-328X(01)00221-2.
short: J. Jerecic, C. Schulze, P.M. Jonas, R. Sprengel, P. Seeburg, J. Bischofberger,
Molecular Brain Research 94 (2001) 96–104.
date_created: 2018-12-11T12:03:38Z
date_published: 2001-10-19T00:00:00Z
date_updated: 2023-05-15T13:42:32Z
day: '19'
doi: 10.1016/S0169-328X(01)00221-2
extern: '1'
external_id:
pmid:
- '11597769'
intvolume: ' 94'
issue: 1-2
language:
- iso: eng
month: '10'
oa_version: None
page: 96 - 104
pmid: 1
publication: Molecular Brain Research
publication_identifier:
issn:
- 0169-328X
publication_status: published
publisher: Elsevier
publist_id: '2892'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive
NR1 (N598R) expression
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '2001'
...
---
_id: '3517'
abstract:
- lang: eng
text: 'A modular multichannel microdrive (''hyperdrive'') is described. The microdrive
uses printed circuit board technology and flexible fused silica capillaries. The
modular design allows for the fabrication of 4-32 independently movable electrodes
or `tetrodes''. The drives are re-usable and re-loading the drive with electrodes
is simple. '
article_processing_charge: No
article_type: original
author:
- first_name: Imre
full_name: Szabo, Imre
last_name: Szabo
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. The application
of printed circuit board technology for fabrication of multi-channel micro-drives.
Journal of Neuroscience Methods. 2001;105(1):105-110. doi:10.1016/S0165-0270(00)00362-9
apa: Szabo, I., Czurkó, A., Csicsvari, J. L., Hirase, H., Leinekugel, X., &
Buzsáki, G. (2001). The application of printed circuit board technology for fabrication
of multi-channel micro-drives. Journal of Neuroscience Methods. Elsevier.
https://doi.org/10.1016/S0165-0270(00)00362-9
chicago: Szabo, Imre, András Czurkó, Jozsef L Csicsvari, Hajima Hirase, Xavier Leinekugel,
and György Buzsáki. “The Application of Printed Circuit Board Technology for Fabrication
of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods. Elsevier,
2001. https://doi.org/10.1016/S0165-0270(00)00362-9.
ieee: I. Szabo, A. Czurkó, J. L. Csicsvari, H. Hirase, X. Leinekugel, and G. Buzsáki,
“The application of printed circuit board technology for fabrication of multi-channel
micro-drives,” Journal of Neuroscience Methods, vol. 105, no. 1. Elsevier,
pp. 105–110, 2001.
ista: Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. 2001.
The application of printed circuit board technology for fabrication of multi-channel
micro-drives. Journal of Neuroscience Methods. 105(1), 105–110.
mla: Szabo, Imre, et al. “The Application of Printed Circuit Board Technology for
Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods,
vol. 105, no. 1, Elsevier, 2001, pp. 105–10, doi:10.1016/S0165-0270(00)00362-9.
short: I. Szabo, A. Czurkó, J.L. Csicsvari, H. Hirase, X. Leinekugel, G. Buzsáki,
Journal of Neuroscience Methods 105 (2001) 105–110.
date_created: 2018-12-11T12:03:45Z
date_published: 2001-01-30T00:00:00Z
date_updated: 2023-05-15T10:50:39Z
day: '30'
doi: 10.1016/S0165-0270(00)00362-9
extern: '1'
external_id:
pmid:
- '11166371'
intvolume: ' 105'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 105 - 110
pmid: 1
publication: Journal of Neuroscience Methods
publication_identifier:
issn:
- 0165-0270
publication_status: published
publisher: Elsevier
publist_id: '2868'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The application of printed circuit board technology for fabrication of multi-channel
micro-drives
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 105
year: '2001'
...
---
_id: '3493'
abstract:
- lang: eng
text: Although agonists and competitive antagonists presumably occupy overlapping
binding sites on ligand-gated channels, these interactions cannot be identical
because agonists cause channel opening whereas antagonists do not. One explanation
is that only agonist binding performs enough work on the receptor to cause the
conformational changes that lead to gating. This idea is supported by agonist
binding rates at GABAA and nicotinic acetylcholine receptors that are slower than
expected for a diffusion-limited process, suggesting that agonist binding involves
an energy-requiring event. This hypothesis predicts that competitive antagonist
binding should require less activation energy than agonist binding. To test this
idea, we developed a novel deconvolution-based method to compare binding and unbinding
kinetics of GABAA receptor agonists and antagonists in outside-out patches from
rat hippocampal neurons. Agonist and antagonist unbinding rates were steeply correlated
with affinity. Unlike the agonists, three of the four antagonists tested had binding
rates that were fast, independent of affinity, and could be accounted for by diffusion-
and dehydration-limited processes. In contrast, agonist binding involved additional
energy-requiring steps, consistent with the idea that channel gating is initiated
by agonist-triggered movements within the ligand binding site. Antagonist binding
does not appear to produce such movements, and may in fact prevent them.
article_processing_charge: No
article_type: original
author:
- first_name: M.V
full_name: Jones, M.V
last_name: Jones
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Y.
full_name: Sahara, Y.
last_name: Sahara
- first_name: G.
full_name: Westbrook, G.
last_name: Westbrook
citation:
ama: Jones M., Jonas PM, Sahara Y, Westbrook G. Microscopic kinetics and energetics
distinguish GABAA receptor agonists from antagonists. Biophysical Journal.
2001;81(5):2660-2670. doi:10.1016/S0006-3495(01)75909-7
apa: Jones, M. ., Jonas, P. M., Sahara, Y., & Westbrook, G. (2001). Microscopic
kinetics and energetics distinguish GABAA receptor agonists from antagonists.
Biophysical Journal. Biophysical Society. https://doi.org/10.1016/S0006-3495(01)75909-7
chicago: Jones, M.V, Peter M Jonas, Y. Sahara, and G. Westbrook. “Microscopic Kinetics
and Energetics Distinguish GABAA Receptor Agonists from Antagonists.” Biophysical
Journal. Biophysical Society, 2001. https://doi.org/10.1016/S0006-3495(01)75909-7 .
ieee: M. . Jones, P. M. Jonas, Y. Sahara, and G. Westbrook, “Microscopic kinetics
and energetics distinguish GABAA receptor agonists from antagonists,” Biophysical
Journal, vol. 81, no. 5. Biophysical Society, pp. 2660–2670, 2001.
ista: Jones M., Jonas PM, Sahara Y, Westbrook G. 2001. Microscopic kinetics and
energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal.
81(5), 2660–2670.
mla: Jones, M. .., et al. “Microscopic Kinetics and Energetics Distinguish GABAA
Receptor Agonists from Antagonists.” Biophysical Journal, vol. 81, no.
5, Biophysical Society, 2001, pp. 2660–70, doi:10.1016/S0006-3495(01)75909-7 .
short: M.. Jones, P.M. Jonas, Y. Sahara, G. Westbrook, Biophysical Journal 81 (2001)
2660–2670.
date_created: 2018-12-11T12:03:37Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-15T13:50:21Z
day: '01'
doi: '10.1016/S0006-3495(01)75909-7 '
extern: '1'
external_id:
pmid:
- '11606279'
intvolume: ' 81'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301733/
month: '11'
oa: 1
oa_version: Published Version
page: 2660 - 2670
pmid: 1
publication: Biophysical Journal
publication_identifier:
issn:
- 0006-3495
publication_status: published
publisher: Biophysical Society
publist_id: '2894'
quality_controlled: '1'
status: public
title: Microscopic kinetics and energetics distinguish GABAA receptor agonists from
antagonists
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 81
year: '2001'
...
---
_id: '2985'
abstract:
- lang: eng
text: The elimination voltammetry with linear scan (EVLS) was used to study adenine
and cytosine reduction signals at the mercury electrode. In comparison with the
linear scan voltammetry (which provides only one unresolved peak), two elimination
functions provide good resolution of individual peaks and significant increase
of sensitivity. The first elimination function eliminates the kinetic current
(Ik) and conserves the diffusion current (Id). The second elimination function
eliminates kinetic and charging currents (Ik and Ic) simultaneously and conserves
the diffusion current (Id). Both functions give two well-resolved peaks of adenine
and cytosine in a wide concentration range, while the linear sweep voltammetry
gives badly resolved peaks due to hydrogen evolution. The best resolution of peaks
is observed in acetate buffer at pH 3.8 and the detection limit for both substances
is 500 nM. The concentration dependence of EVLS peak heights for one substance
at the constant concentration of the other substance is linear. The peak potentials
differ in these elimination functions. The difference in EVLS peak potentials
gives the possibility to evaluate αna. Elimination voltammetry with linear scan
contributes to the resolution of cathodic signals of purine and pyrimidine bases
at very negative potentials near supporting electrolyte discharge. Copyright ©
2001 Elsevier Science B.V.
article_processing_charge: No
article_type: original
author:
- first_name: Libuše
full_name: Trnková, Libuše
last_name: Trnková
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Oldřich
full_name: Dračka, Oldřich
last_name: Dračka
citation:
ama: Trnková L, Friml J, Dračka O. Elimination voltammetry of adenine and cytosine
mixtures. Bioelectrochemistry. 2001;54(2):131-136. doi:10.1016/S1567-5394(01)00119-0
apa: Trnková, L., Friml, J., & Dračka, O. (2001). Elimination voltammetry of
adenine and cytosine mixtures. Bioelectrochemistry. Elsevier. https://doi.org/10.1016/S1567-5394(01)00119-0
chicago: Trnková, Libuše, Jiří Friml, and Oldřich Dračka. “Elimination Voltammetry
of Adenine and Cytosine Mixtures.” Bioelectrochemistry. Elsevier, 2001.
https://doi.org/10.1016/S1567-5394(01)00119-0.
ieee: L. Trnková, J. Friml, and O. Dračka, “Elimination voltammetry of adenine and
cytosine mixtures,” Bioelectrochemistry, vol. 54, no. 2. Elsevier, pp.
131–136, 2001.
ista: Trnková L, Friml J, Dračka O. 2001. Elimination voltammetry of adenine and
cytosine mixtures. Bioelectrochemistry. 54(2), 131–136.
mla: Trnková, Libuše, et al. “Elimination Voltammetry of Adenine and Cytosine Mixtures.”
Bioelectrochemistry, vol. 54, no. 2, Elsevier, 2001, pp. 131–36, doi:10.1016/S1567-5394(01)00119-0.
short: L. Trnková, J. Friml, O. Dračka, Bioelectrochemistry 54 (2001) 131–136.
date_created: 2018-12-11T12:00:42Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-15T14:48:44Z
day: '01'
doi: 10.1016/S1567-5394(01)00119-0
extern: '1'
external_id:
pmid:
- '11694393'
intvolume: ' 54'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 131 - 136
pmid: 1
publication: Bioelectrochemistry
publication_identifier:
isbn:
- 1567-5394
publication_status: published
publisher: Elsevier
publist_id: '3717'
quality_controlled: '1'
status: public
title: Elimination voltammetry of adenine and cytosine mixtures
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 54
year: '2001'
...
---
_id: '3169'
abstract:
- lang: eng
text: Several new algorithms for visual correspondence based on graph cuts [7, 14,
17] have recently been developed. While these methods give very strong results
in practice, they do not handle occlusions properly. Specifically, they treat
the two input images asymmetrically, and they do not ensure that a pixel corresponds
to at most one pixel in the other image. In this paper, we present a new method
which properly addresses occlusions, while preserving the advantages of graph
cut algorithms. We give experimental results for stereo as well as motion, which
demonstrate that our method performs well both at detecting occlusions and computing
disparities.
article_processing_charge: No
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: Ramin
full_name: Zabih, Ramin
last_name: Zabih
citation:
ama: 'Kolmogorov V, Zabih R. Computing visual correspondence with occlusions using
graph cuts. In: Proceedings of the 8th IEEE International Conference on Computer
Vision. Vol 2. IEEE; 2001:508-515. doi:10.1109/ICCV.2001.937668'
apa: 'Kolmogorov, V., & Zabih, R. (2001). Computing visual correspondence with
occlusions using graph cuts. In Proceedings of the 8th IEEE International Conference
on Computer Vision (Vol. 2, pp. 508–515). Vancouver, Canada: IEEE. https://doi.org/10.1109/ICCV.2001.937668'
chicago: Kolmogorov, Vladimir, and Ramin Zabih. “Computing Visual Correspondence
with Occlusions Using Graph Cuts.” In Proceedings of the 8th IEEE International
Conference on Computer Vision, 2:508–15. IEEE, 2001. https://doi.org/10.1109/ICCV.2001.937668.
ieee: V. Kolmogorov and R. Zabih, “Computing visual correspondence with occlusions
using graph cuts,” in Proceedings of the 8th IEEE International Conference
on Computer Vision, Vancouver, Canada, 2001, vol. 2, pp. 508–515.
ista: 'Kolmogorov V, Zabih R. 2001. Computing visual correspondence with occlusions
using graph cuts. Proceedings of the 8th IEEE International Conference on Computer
Vision. ICCV: International Conference on Computer Vision vol. 2, 508–515.'
mla: Kolmogorov, Vladimir, and Ramin Zabih. “Computing Visual Correspondence with
Occlusions Using Graph Cuts.” Proceedings of the 8th IEEE International Conference
on Computer Vision, vol. 2, IEEE, 2001, pp. 508–15, doi:10.1109/ICCV.2001.937668.
short: V. Kolmogorov, R. Zabih, in:, Proceedings of the 8th IEEE International Conference
on Computer Vision, IEEE, 2001, pp. 508–515.
conference:
end_date: 2001-07-14
location: Vancouver, Canada
name: 'ICCV: International Conference on Computer Vision'
start_date: 2001-07-07
date_created: 2018-12-11T12:01:47Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-15T14:45:50Z
day: '01'
doi: 10.1109/ICCV.2001.937668
extern: '1'
intvolume: ' 2'
language:
- iso: eng
month: '08'
oa_version: None
page: 508 - 515
publication: Proceedings of the 8th IEEE International Conference on Computer Vision
publication_identifier:
isbn:
- '0769511430'
publication_status: published
publisher: IEEE
publist_id: '3514'
quality_controlled: '1'
status: public
title: Computing visual correspondence with occlusions using graph cuts
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '2001'
...
---
_id: '3439'
abstract:
- lang: eng
text: High molecular weight DNA was extracted from the primary Neotropical malaria
vector, Anopheles darlingi from Capanema, Pará, Brazil, to create a small insert
genomic library, and then a phagemid library. Enriched sublibraries were constructed
from the phagemid library using a microsatellite oligo primed second strand synthesis
protocol. The resulting 242 760 individual clones were screened. The mean clone
size of the positive clones was 302 bp. Flanking primers were designed for each
suitable microsatellite sequence. Eight polymorphic loci were optimized and characterized.
The allele size ranges are based on 253 samples of A. darlingi from eastern Amazonian
and central Brazil.
acknowledgement: For support in Brazil we thank D. Galiza, R.N.L. Lacerda,E.P.
Santa Rosa, M.N.O. Segura, and R.T.L. de Souza. We also thankM.J. Braun for allowing work on the library construction at theLaboratory
of Molecular Systematics, Washington. Supported byNIH AI 40116 to JEC and Instituto
Evandro Chagas, Belém, Brazil.
article_processing_charge: No
article_type: original
author:
- first_name: Jan
full_name: Conn, Jan
last_name: Conn
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
- first_name: David
full_name: Onyabe, David
last_name: Onyabe
- first_name: Tessa
full_name: Robinson, Tessa
last_name: Robinson
- first_name: Richard
full_name: Wilkerson, Richard
last_name: Wilkerson
- first_name: Marinete
full_name: Povoa, Marinete
last_name: Povoa
citation:
ama: Conn J, Bollback JP, Onyabe D, Robinson T, Wilkerson R, Povoa M. Isolation
of polymorphic microsatellite markers from the malaria vector Anopheles darlingi.
Molecular Ecology Notes. 2001;1(4):223-225. doi: 10.1046/j.1471-8278.2001.00078.x
apa: Conn, J., Bollback, J. P., Onyabe, D., Robinson, T., Wilkerson, R., & Povoa,
M. (2001). Isolation of polymorphic microsatellite markers from the malaria vector
Anopheles darlingi. Molecular Ecology Notes. Wiley-Blackwell. https://doi.org/ 10.1046/j.1471-8278.2001.00078.x
chicago: Conn, Jan, Jonathan P Bollback, David Onyabe, Tessa Robinson, Richard Wilkerson,
and Marinete Povoa. “Isolation of Polymorphic Microsatellite Markers from the
Malaria Vector Anopheles Darlingi.” Molecular Ecology Notes. Wiley-Blackwell,
2001. https://doi.org/
10.1046/j.1471-8278.2001.00078.x.
ieee: J. Conn, J. P. Bollback, D. Onyabe, T. Robinson, R. Wilkerson, and M. Povoa,
“Isolation of polymorphic microsatellite markers from the malaria vector Anopheles
darlingi,” Molecular Ecology Notes, vol. 1, no. 4. Wiley-Blackwell, pp.
223–225, 2001.
ista: Conn J, Bollback JP, Onyabe D, Robinson T, Wilkerson R, Povoa M. 2001. Isolation
of polymorphic microsatellite markers from the malaria vector Anopheles darlingi.
Molecular Ecology Notes. 1(4), 223–225.
mla: Conn, Jan, et al. “Isolation of Polymorphic Microsatellite Markers from the
Malaria Vector Anopheles Darlingi.” Molecular Ecology Notes, vol. 1, no.
4, Wiley-Blackwell, 2001, pp. 223–25, doi:
10.1046/j.1471-8278.2001.00078.x.
short: J. Conn, J.P. Bollback, D. Onyabe, T. Robinson, R. Wilkerson, M. Povoa, Molecular
Ecology Notes 1 (2001) 223–225.
date_created: 2018-12-11T12:03:20Z
date_published: 2001-12-01T00:00:00Z
date_updated: 2023-05-15T13:58:49Z
day: '01'
doi: ' 10.1046/j.1471-8278.2001.00078.x'
extern: '1'
intvolume: ' 1'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 223 - 225
publication: Molecular Ecology Notes
publication_identifier:
issn:
- 1471-8278
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2961'
quality_controlled: '1'
status: public
title: Isolation of polymorphic microsatellite markers from the malaria vector Anopheles
darlingi
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '2001'
...
---
_id: '3440'
abstract:
- lang: eng
text: "Several methods have been proposed to infer the states at the ancestral nodes
on a phylogeny. These methods assume a specific tree and set of branch lengths
when estimating the ancestral character state. Inferences of the ancestral states,
then, are conditioned on the tree and branch lengths being true. We develop a
hierarchical Bayes method for inferring the ancestral states on a tree. The method
integrates over uncertainty in the tree, branch lengths, and substitution model
parameters by using Markov chain Monte Carlo. We compare the hierarchical Bayes
inferences of ancestral states with inferences of ancestral states made under
the assumption that a specific tree is correct. We find that the methods are correlated,
but that accommodating uncertainty in parameters of the phylogenetic model can
make inferences of ancestral states even more uncertain than they would be in
an empirical Bayes analysis.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
citation:
ama: Huelsenbeck J, Bollback JP. Empirical and hierarchical Bayesian estimation
of ancestral states. Systematic Biology. 2001;50(3):351-366. doi:10.1080/10635150119871
apa: Huelsenbeck, J., & Bollback, J. P. (2001). Empirical and hierarchical Bayesian
estimation of ancestral states. Systematic Biology. Oxford University Press.
https://doi.org/10.1080/10635150119871
chicago: Huelsenbeck, John, and Jonathan P Bollback. “Empirical and Hierarchical
Bayesian Estimation of Ancestral States.” Systematic Biology. Oxford University
Press, 2001. https://doi.org/10.1080/10635150119871.
ieee: J. Huelsenbeck and J. P. Bollback, “Empirical and hierarchical Bayesian estimation
of ancestral states,” Systematic Biology, vol. 50, no. 3. Oxford University
Press, pp. 351–366, 2001.
ista: Huelsenbeck J, Bollback JP. 2001. Empirical and hierarchical Bayesian estimation
of ancestral states. Systematic Biology. 50(3), 351–366.
mla: Huelsenbeck, John, and Jonathan P. Bollback. “Empirical and Hierarchical Bayesian
Estimation of Ancestral States.” Systematic Biology, vol. 50, no. 3, Oxford
University Press, 2001, pp. 351–66, doi:10.1080/10635150119871.
short: J. Huelsenbeck, J.P. Bollback, Systematic Biology 50 (2001) 351–366.
date_created: 2018-12-11T12:03:20Z
date_published: 2001-05-01T00:00:00Z
date_updated: 2023-05-15T13:54:01Z
day: '01'
doi: 10.1080/10635150119871
extern: '1'
external_id:
pmid:
- '12116580'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 351 - 366
pmid: 1
publication: Systematic Biology
publication_identifier:
issn:
- 0039-7989
publication_status: published
publisher: Oxford University Press
publist_id: '2960'
quality_controlled: '1'
status: public
title: Empirical and hierarchical Bayesian estimation of ancestral states
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '2001'
...
---
_id: '3438'
abstract:
- lang: eng
text: As a discipline, phylogenetics is becoming transformed by a flood of molecular
data. These data allow broad questions to be asked about the history of life,
but also present difficult statistical and computational problems. Bayesian inference
of phylogeny brings a new perspective to a number of outstanding issues in evolutionary
biology, including the analysis of large phylogenetic trees and complex evolutionary
models and the detection of the footprint of natural selection in DNA sequences.
article_processing_charge: No
author:
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
- first_name: Fredrik
full_name: Ronquist, Fredrik
last_name: Ronquist
- first_name: Rasmus
full_name: Nielsen, Rasmus
last_name: Nielsen
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
citation:
ama: Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. Bayesian inference of phylogeny
and its impact on evolutionary biology. Science. 2001;294(5550):2310-2314.
doi:10.1126/science.1065889
apa: Huelsenbeck, J., Ronquist, F., Nielsen, R., & Bollback, J. P. (2001). Bayesian
inference of phylogeny and its impact on evolutionary biology. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1065889
chicago: Huelsenbeck, John, Fredrik Ronquist, Rasmus Nielsen, and Jonathan P Bollback.
“Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” Science.
American Association for the Advancement of Science, 2001. https://doi.org/10.1126/science.1065889.
ieee: J. Huelsenbeck, F. Ronquist, R. Nielsen, and J. P. Bollback, “Bayesian inference
of phylogeny and its impact on evolutionary biology,” Science, vol. 294,
no. 5550. American Association for the Advancement of Science, pp. 2310–2314,
2001.
ista: Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. 2001. Bayesian inference
of phylogeny and its impact on evolutionary biology. Science. 294(5550), 2310–2314.
mla: Huelsenbeck, John, et al. “Bayesian Inference of Phylogeny and Its Impact on
Evolutionary Biology.” Science, vol. 294, no. 5550, American Association
for the Advancement of Science, 2001, pp. 2310–14, doi:10.1126/science.1065889.
short: J. Huelsenbeck, F. Ronquist, R. Nielsen, J.P. Bollback, Science 294 (2001)
2310–2314.
date_created: 2018-12-11T12:03:20Z
date_published: 2001-12-14T00:00:00Z
date_updated: 2023-05-15T14:10:13Z
day: '14'
doi: 10.1126/science.1065889
extern: '1'
external_id:
pmid:
- '11743192 '
intvolume: ' 294'
issue: '5550'
language:
- iso: eng
month: '12'
oa_version: None
page: 2310 - 2314
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2962'
quality_controlled: '1'
status: public
title: Bayesian inference of phylogeny and its impact on evolutionary biology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 294
year: '2001'
...
---
_id: '3434'
abstract:
- lang: eng
text: "This chapter contains sections titled:\r\n\r\nIntroduction\r\n\r\n- History\r\n\r\n-
Developing an Intuition of Likelihood\r\n\r\n- Method of Maximum Likelihood\r\n\r\n-
Bayesian Inference\r\n\r\n- Markov Chain Monte Carlo\r\n\r\n- Assessing Uncertainty
of Phylogenies\r\n\r\n- Hypothesis Testing and Model Choice\r\n\r\n- Comparative
Analysis\r\n\r\n- Conclusions\r\n\r\n- References"
article_processing_charge: No
author:
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
citation:
ama: 'Huelsenbeck J, Bollback JP. Application of the likelihood function in phylogenetic
analysis. In: Balding D, Bishop M, Cannings C, eds. Handbook of Statistical
Genetics. Wiley-Blackwell; 2001:415-439. doi:10.1002/9780470061619.ch15'
apa: Huelsenbeck, J., & Bollback, J. P. (2001). Application of the likelihood
function in phylogenetic analysis. In D. Balding, M. Bishop, & C. Cannings
(Eds.), Handbook of Statistical Genetics (pp. 415–439). Wiley-Blackwell.
https://doi.org/10.1002/9780470061619.ch15
chicago: Huelsenbeck, John, and Jonathan P Bollback. “Application of the Likelihood
Function in Phylogenetic Analysis.” In Handbook of Statistical Genetics,
edited by David Balding, Martin Bishop, and Chriss Cannings, 415–39. Wiley-Blackwell,
2001. https://doi.org/10.1002/9780470061619.ch15.
ieee: J. Huelsenbeck and J. P. Bollback, “Application of the likelihood function
in phylogenetic analysis,” in Handbook of Statistical Genetics, D. Balding,
M. Bishop, and C. Cannings, Eds. Wiley-Blackwell, 2001, pp. 415–439.
ista: 'Huelsenbeck J, Bollback JP. 2001.Application of the likelihood function in
phylogenetic analysis. In: Handbook of Statistical Genetics. , 415–439.'
mla: Huelsenbeck, John, and Jonathan P. Bollback. “Application of the Likelihood
Function in Phylogenetic Analysis.” Handbook of Statistical Genetics, edited
by David Balding et al., Wiley-Blackwell, 2001, pp. 415–39, doi:10.1002/9780470061619.ch15.
short: J. Huelsenbeck, J.P. Bollback, in:, D. Balding, M. Bishop, C. Cannings (Eds.),
Handbook of Statistical Genetics, Wiley-Blackwell, 2001, pp. 415–439.
date_created: 2018-12-11T12:03:19Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-15T14:43:39Z
day: '01'
doi: 10.1002/9780470061619.ch15
editor:
- first_name: David
full_name: Balding, David
last_name: Balding
- first_name: Martin
full_name: Bishop, Martin
last_name: Bishop
- first_name: Chriss
full_name: Cannings, Chriss
last_name: Cannings
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 415 - 439
publication: Handbook of Statistical Genetics
publication_identifier:
isbn:
- '9781119429142 '
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2966'
quality_controlled: '1'
status: public
title: Application of the likelihood function in phylogenetic analysis
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '2982'
abstract:
- lang: eng
text: Polar auxin transport is crucial for the regulation of auxin action and required
for some light-regulated responses during plant development. We have found that
two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated
genes, and tir3, known for its reduced auxin transport - have similar defects
and define mutations in a single gene that we have renamed BIG. BIG is very similar
to the Drosophila gene Calossin/Pushover, a member of a gene family also present
in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary
in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling
experiments indicate that altered expression of multiple light-regulated genes
in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression
of an auxin biosynthetic gene, suggesting that normal auxin distribution is required
to maintain low-level expression of these genes in the dark. Double mutants of
tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent
growth of the inflorescence. Chemical inhibitors of auxin transport change the
intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants,
supporting the idea that BIG is required for normal auxin efflux.
acknowledgement: "We thank Kim Hanson and Melissa McCarthy for technical support,
and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating
and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were
supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning
this manuscript. This work was supported by grants from the Department of Energy
(DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by
grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes
of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to
K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate
Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow
of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article
were defrayed in part by payment of page charges. This article must therefore be
hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate
this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Pedro
full_name: Gil, Pedro
last_name: Gil
- first_name: Elizabeth
full_name: Dewey, Elizabeth
last_name: Dewey
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Yunde
full_name: Zhao, Yunde
last_name: Zhao
- first_name: Kimberley
full_name: Snowden, Kimberley
last_name: Snowden
- first_name: Jo
full_name: Putterill, Jo
last_name: Putterill
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Mark
full_name: Estelle, Mark
last_name: Estelle
- first_name: Joanne
full_name: Chory, Joanne
last_name: Chory
citation:
ama: 'Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for
polar auxin transport in Arabidopsis. Genes and Development. 2001;15(15):1985-1997.
doi:10.1101/gad.905201'
apa: 'Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory,
J. (2001). BIG: A calossin-like protein required for polar auxin transport in
Arabidopsis. Genes and Development. Cold Spring Harbor Laboratory Press.
https://doi.org/10.1101/gad.905201'
chicago: 'Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden,
Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like
Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development.
Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.905201.'
ieee: 'P. Gil et al., “BIG: A calossin-like protein required for polar auxin
transport in Arabidopsis,” Genes and Development, vol. 15, no. 15. Cold
Spring Harbor Laboratory Press, pp. 1985–1997, 2001.'
ista: 'Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle
M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport
in Arabidopsis. Genes and Development. 15(15), 1985–1997.'
mla: 'Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin
Transport in Arabidopsis.” Genes and Development, vol. 15, no. 15, Cold
Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:10.1101/gad.905201.'
short: P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme,
M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-16T11:59:47Z
day: '01'
doi: 10.1101/gad.905201
extern: '1'
external_id:
pmid:
- '11485992'
intvolume: ' 15'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/
month: '08'
oa: 1
oa_version: Published Version
page: 1985 - 1997
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3720'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'BIG: A calossin-like protein required for polar auxin transport in Arabidopsis'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '2984'
abstract:
- lang: eng
text: Auxins represent an important class of plant hormone that regulate plant development.
Plants use specialized carrier proteins to transport the auxin indole-3-acetic
acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport
has been assumed to represent the sole mode of long distance IAA movement. Localization
of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based
IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of
root protophloem cells, is proposed to promote the acropetal, post-phloem movement
of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant
root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1
localization to columella and lateral root cap tissues of the Arabidopsis root
apex reveals that the auxin permease regulates a second IAA transport pathway.
Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary
for root gravitropism by facilitating basipetal auxin transport to distal elongation
zone tissues.
acknowledgement: "We thank Ben Scheres and Marcus Grebe for critically reading the
manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis
Baker for valuable discussion. This work was funded by the BBSRC and European Commission
grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs
of this article were defrayed in part by payment of page charges. This article must
therefore be hereby marked “advertisement” in accordance with 18 USC section 1734
solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Alan
full_name: Marchant, Alan
last_name: Marchant
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
citation:
ama: Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1
suggests two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex. Genes and Development. 2001;15(20):2648-2653. doi:10.1101/gad.210501
apa: Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., &
Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally
distinct hormone transport pathways operate in the Arabidopsis root apex. Genes
and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.210501
chicago: Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg,
Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests
Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis
Root Apex.” Genes and Development. Cold Spring Harbor Laboratory Press,
2001. https://doi.org/10.1101/gad.210501.
ieee: R. Swarup et al., “Localization of the auxin permease AUX1 suggests
two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex,” Genes and Development, vol. 15, no. 20. Cold Spring Harbor
Laboratory Press, pp. 2648–2653, 2001.
ista: Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001.
Localization of the auxin permease AUX1 suggests two functionally distinct hormone
transport pathways operate in the Arabidopsis root apex. Genes and Development.
15(20), 2648–2653.
mla: Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two
Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root
Apex.” Genes and Development, vol. 15, no. 20, Cold Spring Harbor Laboratory
Press, 2001, pp. 2648–53, doi:10.1101/gad.210501.
short: R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett,
Genes and Development 15 (2001) 2648–2653.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-10-15T00:00:00Z
date_updated: 2023-05-16T11:37:53Z
day: '15'
doi: 10.1101/gad.210501
extern: '1'
external_id:
pmid:
- '11641271'
intvolume: ' 15'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC312818/
month: '10'
oa: 1
oa_version: Published Version
page: 2648 - 2653
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- Genes and Development
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3718'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of the auxin permease AUX1 suggests two functionally distinct
hormone transport pathways operate in the Arabidopsis root apex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '2981'
abstract:
- lang: eng
text: Plants contain a novel unique subfamily of Rho GTPases, vital components of
cellular signalling networks. Here we report a general role for some members of
this family in polarized plant growth processes. We show that Arabidopsis AtRop4
and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates.
We localized AtRop proteins in root meristem cells to the cross-wall and cell
plate membranes. Polar localization of AtRops in trichoblasts specifies the growth
sites for emerging root hairs. These sites were visible before budding and elongation
of the Arabidopsis root hair when AtRops accumulated at their tips. Expression
of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic
Arabidopsis plants abolished polarized growth and delocalized the tip-focused
Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but
not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results
demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse
growth.
acknowledgement: We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars
Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the
manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work
was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98
0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient
of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Arthur
full_name: Molendijk, Arthur
last_name: Molendijk
- first_name: Friedrich
full_name: Bischoff, Friedrich
last_name: Bischoff
- first_name: Chadalavada
full_name: Rajendrakumar, Chadalavada
last_name: Rajendrakumar
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Markus
full_name: Braun, Markus
last_name: Braun
- first_name: Simon
full_name: Gilroy, Simon
last_name: Gilroy
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases
are localized to tips of root hairs and control polar growth. EMBO Journal.
2001;20(11):2779-2788. doi:10.1093/emboj/20.11.2779
apa: Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy,
S., & Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to
tips of root hairs and control polar growth. EMBO Journal. Wiley-Blackwell.
https://doi.org/10.1093/emboj/20.11.2779
chicago: Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří
Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop
GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO
Journal. Wiley-Blackwell, 2001. https://doi.org/10.1093/emboj/20.11.2779.
ieee: A. Molendijk et al., “Arabidopsis thaliana Rop GTPases are localized
to tips of root hairs and control polar growth,” EMBO Journal, vol. 20,
no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.
ista: Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme
K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs
and control polar growth. EMBO Journal. 20(11), 2779–2788.
mla: Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to
Tips of Root Hairs and Control Polar Growth.” EMBO Journal, vol. 20, no.
11, Wiley-Blackwell, 2001, pp. 2779–88, doi:10.1093/emboj/20.11.2779.
short: A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy,
K. Palme, EMBO Journal 20 (2001) 2779–2788.
date_created: 2018-12-11T12:00:40Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-16T12:07:45Z
day: '01'
doi: 10.1093/emboj/20.11.2779
extern: '1'
external_id:
pmid:
- '11387211'
intvolume: ' 20'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/
month: '06'
oa: 1
oa_version: Published Version
page: 2779 - 2788
pmid: 1
publication: EMBO Journal
publication_identifier:
issn:
- 0261-4189
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control
polar growth
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2001'
...
---
_id: '2983'
abstract:
- lang: eng
text: Polar transport of the phytohormone auxin mediates various processes in plant
growth and development, such as apical dominance, tropisms, vascular patterning
and axis formation. This view is based largely on the effects of polar auxin transport
inhibitors. These compounds disrupt auxin efflux from the cell but their mode
of action is unknown. It is thought that polar auxin flux is caused by the asymmetric
distribution of efflux carriers acting at the plasma membrane. The polar localization
of efflux carrier candidate PIN1 supports this model. Here we show that the seemingly
static localization of PIN1 results from rapid actin-dependent cycling between
the plasma membrane and endosomal compartments. Auxin transport inhibitors block
PIN1 cycling and inhibit trafficking of membrane proteins that are unrelated to
auxin transport. Our data suggest that PIN1 cycling is of central importance for
auxin transport and that auxin transport inhibitors affect efflux by generally
interfering with membrane-trafficking processes. In support of our conclusion,
the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of
auxin transport inhibitors.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Niko
full_name: Geldner, Niko
last_name: Geldner
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: York
full_name: Stierhof, York
last_name: Stierhof
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. Auxin transport inhibitors
block PIN1 cycling and vesicle trafficking. Nature. 2001;413(6854):425-428.
doi:10.1038/35096571
apa: Geldner, N., Friml, J., Stierhof, Y., Jürgens, G., & Palme, K. (2001).
Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature.
Nature Publishing Group. https://doi.org/10.1038/35096571
chicago: Geldner, Niko, Jiří Friml, York Stierhof, Gerd Jürgens, and Klaus Palme.
“Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” Nature.
Nature Publishing Group, 2001. https://doi.org/10.1038/35096571.
ieee: N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, and K. Palme, “Auxin transport
inhibitors block PIN1 cycling and vesicle trafficking,” Nature, vol. 413,
no. 6854. Nature Publishing Group, pp. 425–428, 2001.
ista: Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. 2001. Auxin transport
inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854), 425–428.
mla: Geldner, Niko, et al. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle
Trafficking.” Nature, vol. 413, no. 6854, Nature Publishing Group, 2001,
pp. 425–28, doi:10.1038/35096571.
short: N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, K. Palme, Nature 413 (2001)
425–428.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-09-27T00:00:00Z
date_updated: 2023-05-16T11:51:44Z
day: '27'
doi: 10.1038/35096571
extern: '1'
external_id:
pmid:
- '11574889'
intvolume: ' 413'
issue: '6854'
language:
- iso: eng
month: '09'
oa_version: None
page: 425 - 428
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '3719'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 413
year: '2001'
...
---
_id: '2736'
abstract:
- lang: eng
text: We consider the time evolution of N bosonic particles interacting via a mean
field Coulomb potential. Suppose the initial state is a product wavefunction.
We show that at any finite time the correlation functions factorize in the limit
N → ∞. Furthermore, the limiting one particle density matrix satisfies the nonlinear
Hartree equation. The key ingredients are the uniqueness of the BBGKY hierarchy
for the correlation functions and a new apriori estimate for the many-body Schrödinger
equations.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Derivation of the nonlinear Schrödinger equation from a many
body Coulomb system. Advances in Theoretical and Mathematical Physics.
2001;5(6):1169-1205. doi:10.48550/arXiv.math-ph/0111042
apa: Erdös, L., & Yau, H. (2001). Derivation of the nonlinear Schrödinger equation
from a many body Coulomb system. Advances in Theoretical and Mathematical Physics.
International Press. https://doi.org/10.48550/arXiv.math-ph/0111042
chicago: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger
Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical
Physics. International Press, 2001. https://doi.org/10.48550/arXiv.math-ph/0111042.
ieee: L. Erdös and H. Yau, “Derivation of the nonlinear Schrödinger equation from
a many body Coulomb system,” Advances in Theoretical and Mathematical Physics,
vol. 5, no. 6. International Press, pp. 1169–1205, 2001.
ista: Erdös L, Yau H. 2001. Derivation of the nonlinear Schrödinger equation from
a many body Coulomb system. Advances in Theoretical and Mathematical Physics.
5(6), 1169–1205.
mla: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation
from a Many Body Coulomb System.” Advances in Theoretical and Mathematical
Physics, vol. 5, no. 6, International Press, 2001, pp. 1169–205, doi:10.48550/arXiv.math-ph/0111042.
short: L. Erdös, H. Yau, Advances in Theoretical and Mathematical Physics 5 (2001)
1169–1205.
date_created: 2018-12-11T11:59:20Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-16T12:12:41Z
day: '01'
doi: 10.48550/arXiv.math-ph/0111042
extern: '1'
external_id:
arxiv:
- math-ph/0111042
intvolume: ' 5'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0111042
month: '11'
oa: 1
oa_version: Published Version
page: 1169 - 1205
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
issn:
- 1095-0761
publication_status: published
publisher: International Press
publist_id: '4156'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Derivation of the nonlinear Schrödinger equation from a many body Coulomb system
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '2001'
...
---
_id: '2735'
abstract:
- lang: eng
text: We establish the exact low-energy asymptotics of the integrated density of
states (Lifschitz tail) in a homogeneous magnetic field and Poissonian impurities
with a repulsive single-site potential of Gaussian decay. It has been known that
the Gaussian potential tail discriminates between the so-called “classical” and
“quantum” regimes, and precise asymptotics are known in these cases. For the borderline
case, the coexistence of the classical and quantum regimes was conjectured. Here
we settle this last remaining open case to complete the full picture of the magnetic
Lifschitz tails.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Lifschitz tail in a magnetic field: Coexistence of classical and
quantum behavior in the borderline case. Probability Theory and Related Fields.
2001;121(2):219-236. doi:10.1007/PL00008803'
apa: 'Erdös, L. (2001). Lifschitz tail in a magnetic field: Coexistence of classical
and quantum behavior in the borderline case. Probability Theory and Related
Fields. Springer. https://doi.org/10.1007/PL00008803'
chicago: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical
and Quantum Behavior in the Borderline Case.” Probability Theory and Related
Fields. Springer, 2001. https://doi.org/10.1007/PL00008803.'
ieee: 'L. Erdös, “Lifschitz tail in a magnetic field: Coexistence of classical and
quantum behavior in the borderline case,” Probability Theory and Related Fields,
vol. 121, no. 2. Springer, pp. 219–236, 2001.'
ista: 'Erdös L. 2001. Lifschitz tail in a magnetic field: Coexistence of classical
and quantum behavior in the borderline case. Probability Theory and Related Fields.
121(2), 219–236.'
mla: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical
and Quantum Behavior in the Borderline Case.” Probability Theory and Related
Fields, vol. 121, no. 2, Springer, 2001, pp. 219–36, doi:10.1007/PL00008803.'
short: L. Erdös, Probability Theory and Related Fields 121 (2001) 219–236.
date_created: 2018-12-11T11:59:19Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-05-16T12:20:42Z
day: '01'
doi: 10.1007/PL00008803
extern: '1'
external_id:
arxiv:
- math-ph/0003023
intvolume: ' 121'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/math-ph/0003023
month: '10'
oa: 1
oa_version: Published Version
page: 219 - 236
publication: Probability Theory and Related Fields
publication_identifier:
issn:
- 0044-3719
publication_status: published
publisher: Springer
publist_id: '4157'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior
in the borderline case'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 121
year: '2001'
...
---
_id: '2734'
abstract:
- lang: eng
text: In this paper we describe an intrinsically geometric way of producing magnetic
fields on S3 and R3 for which the corresponding Dirac operators have a non-trivial
kernel. In many cases we are able to compute the dimension of the kernel. In particular
we can give examples where the kernel has any given dimension. This generalizes
the examples of Loss and Yau [1].
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Erdös L, Solovej J. The kernel of Dirac operators on S3 and R3. Reviews
in Mathematical Physics. 2001;13(10):1247-1280. doi:10.1142/S0129055X01000983
apa: Erdös, L., & Solovej, J. (2001). The kernel of Dirac operators on S3 and
R3. Reviews in Mathematical Physics. World Scientific Publishing. https://doi.org/10.1142/S0129055X01000983
chicago: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and
R3.” Reviews in Mathematical Physics. World Scientific Publishing, 2001.
https://doi.org/10.1142/S0129055X01000983.
ieee: L. Erdös and J. Solovej, “The kernel of Dirac operators on S3 and R3,” Reviews
in Mathematical Physics, vol. 13, no. 10. World Scientific Publishing, pp.
1247–1280, 2001.
ista: Erdös L, Solovej J. 2001. The kernel of Dirac operators on S3 and R3. Reviews
in Mathematical Physics. 13(10), 1247–1280.
mla: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.”
Reviews in Mathematical Physics, vol. 13, no. 10, World Scientific Publishing,
2001, pp. 1247–80, doi:10.1142/S0129055X01000983.
short: L. Erdös, J. Solovej, Reviews in Mathematical Physics 13 (2001) 1247–1280.
date_created: 2018-12-11T11:59:19Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-05-16T12:24:25Z
day: '01'
doi: 10.1142/S0129055X01000983
extern: '1'
external_id:
arxiv:
- math-ph/0001036
intvolume: ' 13'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/math-ph/0001036
month: '10'
oa: 1
oa_version: Published Version
page: 1247 - 1280
publication: Reviews in Mathematical Physics
publication_identifier:
issn:
- 0129-055X
publication_status: published
publisher: World Scientific Publishing
publist_id: '4158'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The kernel of Dirac operators on S3 and R3
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...
---
_id: '2611'
abstract:
- lang: eng
text: Research using animal models of neuropathic pain has revealed sympathetic
sprouting onto dorsal root ganglion cells. More recently, sensory fibre sprouting
onto dorsal root ganglion cells has also been observed. Previous work in our laboratory
demonstrated persistent sympathetic fibre sprouting in the skin of the rat lower
lip following sensory denervation of this region. Therefore, we applied immunocytochemistry
to determine the effects of sympathectomies on the terminal fields of sensory
fibres. The superior cervical ganglia were removed bilaterally and the effects
on the innervation of the skin of the rat lower lip were observed 1, 2, 3, 4,
6 and 8 weeks post-surgery. Substance P and dopamine-β-hydroxylase immunoreactivities
were used to identify a subset of sensory and sympathetic fibres, respectively.
We also assessed neurokinin-1 receptor immunoreactivity. Quantitative data was
obtained with the aid of an image analysis system. In controls, the epidermis
and upper dermis were innervated by substance P-immunoreactive fibres only and
upper dermal blood vessels possessed the highest density of neurokinin-1 receptor
immunoreactivity. Blood vessels in the lower dermis were innervated by both substance
P- and dopamine-β-hydroxylase-immunoreactive fibres. Following sympathectomies,
substance P-immunoreactive fibres in the epidermis and upper dermis were more
intensely labelled only 1 and 2 weeks post-surgery when compared to sham controls.
The length of substance P-immunoreactive fibres in this region was also increased
only on the second week. Neurokinin-1 receptor immunoreactivity in the upper dermis
was slightly decreased 1 and 2 weeks post-surgery. In the lower dermis, substance
P-immunoreactive fibres associated with blood vessels were more intensely labelled
only 1 and 2 weeks post-surgery, and at all post-surgical time points studied,
blood vessels in this region were devoid of dopamine-β-hydroxylase-immunoreactive
fibres. The length of substance P-immunoreactive fibres was increased from the
first to the third week post-surgery in the lower dermis. These results indicate
that sympathectomies lead to transient changes in substance P-immunoreactive fibre
innervation and neurokinin-1 receptor expression in rat lower lip skin. The effects
are most prominent in the lower dermis probably due to a greater local concentration
of nerve growth factor in this region. The plasticity of the interactions between
sensory and sympathetic fibres may prove important in the regulation of skin microcirculation
and in the generation of painful sensations under normal conditions or following
peripheral nerve injuries.
acknowledgement: 'The work contained in this manuscript was sponsored by the Canadian
MRC, Grants # MT-12170 and MoP-38093. The authors would like to thank Sylvain Cote
for technical assistance and Sid Parkinson for editorial assistance.'
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Sympathectomies lead to
transient substance P-immunoreactive sensory fibre plasticity in the rat skin.
Neuroscience. 2001;108(1):157-166. doi:10.1016/S0306-4522(01)00158-0
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00158-0
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory
Fibre Plasticity in the Rat Skin.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00158-0.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin,” Neuroscience, vol. 108, no. 1. Elsevier, pp. 157–166, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. 108(1), 157–166.
mla: Ruocco, Isabella, et al. “Sympathectomies Lead to Transient Substance P-Immunoreactive
Sensory Fibre Plasticity in the Rat Skin.” Neuroscience, vol. 108, no.
1, Elsevier, 2001, pp. 157–66, doi:10.1016/S0306-4522(01)00158-0.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Neuroscience 108
(2001) 157–166.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-12-05T00:00:00Z
date_updated: 2023-05-22T12:15:44Z
day: '05'
doi: 10.1016/S0306-4522(01)00158-0
extern: '1'
external_id:
pmid:
- '11738139'
intvolume: ' 108'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 157 - 166
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4286'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sympathectomies lead to transient substance P-immunoreactive sensory fibre
plasticity in the rat skin
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '2001'
...
---
_id: '2612'
abstract:
- lang: eng
text: 'We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR)
subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons
(MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies
of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy,
the immunogold-silver method for GABABR1 was combined with the immunoperoxidase
method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver
particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm
of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were
rarely associated with synaptic membrane specialization or extrasynaptic sites
of plasma membrane. It has been indicated that GABABR1 may not be transported
to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1
in the cell body of the rat MTN neurons might not be involved in the synaptic
transmission.'
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39870262, 39970239), from the Foundation for
University Key Teacher of the Ministry of Education of China, and from the Ministry
of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Peng
full_name: Chen, Peng
last_name: Chen
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB
receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience
Letters. 2001;315(1-2):93-97. doi:10.1016/S0304-3940(01)02321-7
apa: Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., & Mizuno,
N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic
trigeminal nucleus neurons in the rat. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(01)02321-7
chicago: Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi
Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors
in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters.
Elsevier, 2001. https://doi.org/10.1016/S0304-3940(01)02321-7.
ieee: J. Li et al., “Immunocytochemical localization of GABAB receptors in
mesencephalic trigeminal nucleus neurons in the rat,” Neuroscience Letters,
vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.
ista: Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical
localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in
the rat. Neuroscience Letters. 315(1–2), 93–97.
mla: Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic
Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters, vol. 315,
no. 1–2, Elsevier, 2001, pp. 93–97, doi:10.1016/S0304-3940(01)02321-7.
short: J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno,
Neuroscience Letters 315 (2001) 93–97.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-11-23T00:00:00Z
date_updated: 2023-05-22T12:30:05Z
day: '23'
doi: 10.1016/S0304-3940(01)02321-7
extern: '1'
external_id:
pmid:
- '11711223'
intvolume: ' 315'
issue: 1-2
language:
- iso: eng
month: '11'
oa_version: None
page: 93 - 97
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4287'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal
nucleus neurons in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 315
year: '2001'
...
---
_id: '2709'
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Long time dynamics of an electron in a weakly coupled phonon field.
In: 13th International Congress of Mathematical Physics. International
Press of Boston; 2001:273-281.'
apa: Erdös, L. (2001). Long time dynamics of an electron in a weakly coupled phonon
field. In 13th International Congress of Mathematical Physics (pp. 273–281). International
Press of Boston.
chicago: Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon
Field.” In 13th International Congress of Mathematical Physics, 273–81. International
Press of Boston, 2001.
ieee: L. Erdös, “Long time dynamics of an electron in a weakly coupled phonon field,”
in 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–281.
ista: 'Erdös L. 2001.Long time dynamics of an electron in a weakly coupled phonon
field. In: 13th International Congress of Mathematical Physics. , 273–281.'
mla: Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon
Field.” 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–81.
short: L. Erdös, in:, 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–281.
date_created: 2018-12-11T11:59:11Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-22T12:11:29Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 273 - 281
publication: 13th International Congress of Mathematical Physics
publication_identifier:
isbn:
- '9781571460851'
publication_status: published
publisher: ' International Press of Boston'
publist_id: '4187'
quality_controlled: '1'
status: public
title: Long time dynamics of an electron in a weakly coupled phonon field
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '2610'
abstract:
- lang: eng
text: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination
to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After
the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype,
we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals
aged 12 weeks and older, subthreshold doses of these drugs induced seizures in
mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by
three standard anticonvulsant drugs, but not by the group III selective mGluR
agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs
of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed
no major changes in synaptic properties in two slice preparations. However, slightly
increased excitability was evident in hippocampal slices. In addition, there was
slower recovery from frequency facilitation in cortical slices, suggesting a role
for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings
suggest that mGluR7 receptors have a unique role in regulating neuronal excitability
and that these receptors may be a novel target for the development of anticonvulsant
drugs.
acknowledgement: This work was supported in part by the Biotechnology and Biological
Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg
for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8
cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination
of brain sections, Christoph Wiessner for help with plots and statistics, Valerie
Schuler for help with Western blots, and the team of the Novartis special strain
breeding facility for their support.
article_processing_charge: No
article_type: original
author:
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Trevor
full_name: Bushell, Trevor
last_name: Bushell
- first_name: Vernon
full_name: Clarke, Vernon
last_name: Clarke
- first_name: Andrei
full_name: Rozov, Andrei
last_name: Rozov
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Chantal
full_name: Portet, Chantal
last_name: Portet
- first_name: Fabrizio
full_name: Gasparini, Fabrizio
last_name: Gasparini
- first_name: Markus
full_name: Schmutz, Markus
last_name: Schmutz
- first_name: Klaus
full_name: Klebs, Klaus
last_name: Klebs
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Rainer
full_name: Kühn, Rainer
last_name: Kühn
- first_name: Thomas
full_name: Knoepfel, Thomas
last_name: Knoepfel
- first_name: Markus
full_name: Schroeder, Markus
last_name: Schroeder
- first_name: David
full_name: Hampson, David
last_name: Hampson
- first_name: Valerie
full_name: Collett, Valerie
last_name: Collett
- first_name: Congxiao
full_name: Zhang, Congxiao
last_name: Zhang
- first_name: Robert
full_name: Duvoisin, Robert
last_name: Duvoisin
- first_name: Graham
full_name: Collingridge, Graham
last_name: Collingridge
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
citation:
ama: Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice
lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745.
doi:10.1523/JNEUROSCI.21-22-08734.2001
apa: Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C.,
… Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001
chicago: Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev,
Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in
Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience.
Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001.
ieee: G. Sansig et al., “Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no.
22. Society for Neuroscience, pp. 8734–8745, 2001.
ista: Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F,
Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson
D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased
seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal
of Neuroscience. 21(22), 8734–8745.
mla: Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic
Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society
for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001.
short: G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini,
M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder,
D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten,
Journal of Neuroscience 21 (2001) 8734–8745.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-11-15T00:00:00Z
date_updated: 2023-05-24T08:47:53Z
day: '15'
doi: 10.1523/JNEUROSCI.21-22-08734.2001
extern: '1'
external_id:
pmid:
- '11698585'
intvolume: ' 21'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/
month: '11'
oa: 1
oa_version: Published Version
page: 8734 - 8745
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4288'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor
7
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '2609'
abstract:
- lang: eng
text: 'The metabotropic glutamate receptors (mGluRs) have distinct distribution
patterns in the CNS but subtypes within group I or group III mGluRs share similar
ultrastructural localization relative to neurotransmitter release sites: group
I mGluRs are concentrated in an annulus surrounding the edge of the postsynaptic
density, whereas group III mGluRs are concentrated in the presynaptic active zone.
One of the group II subtypes, mGluR2, is expressed in both pre- and postsynaptic
elements, having no close association with synapses. In order to determine if
such a distribution is common to another group II subtype, mGluR3, an antibody
was raised against a carboxy-terminus of mGluR3 and used for light and electron
microscopic immunohistochemistry in the mouse CNS. The antibody reacted strongly
with mGluR3, but it also reacted, though only weakly, with mGluR2. Therefore,
to examine mGluR3-selective distribution, we used mGluR2-deficient mice as well
as wild-type mice. Strong immunoreactivity for mGluR3 was found in the cerebral
cortex, striatum, dentate gyrus of the hippocampus, olfactory tubercle, lateral
septal nucleus, lateral and basolateral amygdaloid nuclei, and nucleus of the
lateral olfactory tract. Pre-embedding immunoperoxidase and immunogold methods
revealed mGluR3 labeling in both presynaptic and postsynaptic elements, and also
in glial profiles. Double labeling revealed that the vast majority of mGluR3 in
presynaptic elements is not closely associated with glutamate and GABA release
sites in the striatum and thalamus, respectively. However, in the spines of the
dentate granule cells, the highest receptor density was found in perisynaptic
sites (20% of immunogold particles within 60 nm from the edge of postsynaptic
membrane specialization) followed by a decreasing receptor density away from the
synapses (to ∼5% of particles per 60 nm). Furthermore, 19% of immunogold particles
were located in asymmetrical postsynaptic specialization, indicating an association
of mGluR3 to glutamatergic synapses. The present results indicate that the localization
of mGluR3 is rather similar to that of group I mGluRs in the postsynaptic elements,
suggesting a unique functional role of mGluR3 in glutamatergic neurotransmission
in the CNS.'
acknowledgement: We are grateful to M. Yokoi and S. Nakanishi for kindly providing
us with the mGluR2-de¢cient mice and F. Ferraguti for mGluR8b cDNA. The technical
assistance of S. Doi and the photographic assistance of A. Uesugi are acknowledged.
This work has been supported by research grants from the Ministry of Education,
Sports, Culture, Science, and Technology of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Y
full_name: Tamaru, Y
last_name: Tamaru
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate
receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic
sites. Neuroscience. 2001;106(3):481-503. doi:10.1016/S0306-4522(01)00305-0'
apa: 'Tamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001). Distribution
of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location
relative to pre- and postsynaptic sites. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00305-0'
chicago: 'Tamaru, Y, Sakashi Nomura, Noboru Mizuno, and Ryuichi Shigemoto. “Distribution
of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location
Relative to Pre- and Postsynaptic Sites.” Neuroscience. Elsevier, 2001.
https://doi.org/10.1016/S0306-4522(01)00305-0.'
ieee: 'Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto, “Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites,” Neuroscience, vol. 106, no. 3. Elsevier,
pp. 481–503, 2001.'
ista: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. 2001. Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites. Neuroscience. 106(3), 481–503.'
mla: 'Tamaru, Y., et al. “Distribution of Metabotropic Glutamate Receptor MGluR3
in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.”
Neuroscience, vol. 106, no. 3, Elsevier, 2001, pp. 481–503, doi:10.1016/S0306-4522(01)00305-0.'
short: Y. Tamaru, S. Nomura, N. Mizuno, R. Shigemoto, Neuroscience 106 (2001) 481–503.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-09-27T00:00:00Z
date_updated: 2023-05-24T08:51:17Z
day: '27'
doi: 10.1016/S0306-4522(01)00305-0
extern: '1'
external_id:
pmid:
- '11591452'
intvolume: ' 106'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 481 - 503
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential
location relative to pre- and postsynaptic sites'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 106
year: '2001'
...
---
_id: '2608'
abstract:
- lang: eng
text: The regulation of neurotransmitter receptors during synapse formation has
been studied extensively at the neuromuscular junction, but little is known about
the development of excitatory neurotransmitter receptors during synaptogenesis
in central synapses. In this study we show qualitatively and quantitatively that
a receptor undergoes changes in localisation on the surface of rat Purkinje cells
during development in association with its excitatory synapses. The presence of
mGluR1α at parallel and climbing fibre synapses on developing Purkinje cells was
studied using high-resolution immunoelectron microscopy. Immunoreactivity for
mGluR1α was detected from embryonic day 18 in Purkinje cells, and showed dramatic
changes in its localisation with age. At early postnatal ages (P0 and P3), mGluR1α
was found both in somata and stem dendrites but was not usually associated with
synaptic contacts. At P7, mGluR1α became concentrated in somatic spines associated
with climbing fibres and in the growing dendritic arborisation even before innervation
by parallel fibres. During the second and third postnatal week, when spines and
parallel fibre synapses were generated, mGluR1α became progressively concentrated
in the molecular layer, particularly in the synaptic specialisations. As a result,
during the fourth postnatal week, the pattern and level of mGluR1α expression
became similar to the adult and mGluR1α appeared in high density in perisynaptic
sites. Our results indicate that mGluR1α is present in the developing Purkinje
cells prior to their innervation by climbing and parallel fibres and demonstrate
that this receptor undergoes a dynamic and specific regulation during postnatal
development in association with the establishment of synaptic inputs to Purkinje
cell.
acknowledgement: öWe thank Drs. Paul Bolam, Ole Paulsen, Je¡ McIlhinney, Alfonso Faire¨n
and Francisco Ciruela for reviewing a previous version of this manuscript and Mrs
Alexandra Salewski for the English revision of the manuscript. We also want to thank
Dr. Peter Somogyi for offering the facilities of the MRC Anatomical Neuropharmacology
Unit to carry out part of this study. This work was supported by a Grant from the
European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministry of Education
(DGES PM 97-0082 to J.M.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: José
full_name: Juíz, José
last_name: Juíz
citation:
ama: López Bendito G, Shigemoto R, Luján R, Juíz J. Developmental changes in the
localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje
cells. Neuroscience. 2001;105(2):413-429. doi:10.1016/S0306-4522(01)00188-9
apa: López Bendito, G., Shigemoto, R., Luján, R., & Juíz, J. (2001). Developmental
changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00188-9
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Rafael Luján, and José Juíz.
“Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic
Glutamate Receptors in Purkinje Cells.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00188-9.
ieee: G. López Bendito, R. Shigemoto, R. Luján, and J. Juíz, “Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells,” Neuroscience, vol. 105, no. 2. Elsevier, pp. 413–429,
2001.
ista: López Bendito G, Shigemoto R, Luján R, Juíz J. 2001. Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. 105(2), 413–429.
mla: López Bendito, Guillermina, et al. “Developmental Changes in the Localisation
of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.”
Neuroscience, vol. 105, no. 2, Elsevier, 2001, pp. 413–29, doi:10.1016/S0306-4522(01)00188-9.
short: G. López Bendito, R. Shigemoto, R. Luján, J. Juíz, Neuroscience 105 (2001)
413–429.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-07-27T00:00:00Z
date_updated: 2023-05-24T09:31:48Z
day: '27'
doi: 10.1016/S0306-4522(01)00188-9
extern: '1'
external_id:
pmid:
- '11672608 '
intvolume: ' 105'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 413 - 429
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4290'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental changes in the localisation of the mGluR1α subtype of metabotropic
glutamate receptors in Purkinje cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 105
year: '2001'
...
---
_id: '2607'
abstract:
- lang: eng
text: Alternative splicing in the mGluR5 gene generates two different receptor isoforms,
of which expression is developmentally regulated. However, little is known about
the functional significance of mGluR5 splice variants. We have examined the functional
coupling, subcellular targeting, and effect on neuronal differentiation of epitope-tagged
mGluR5 isoforms by expression in neuroblastoma NG108-15 cells. We found that both
mGluR5 splice variants give rise to comparable [Ca2+]i transients and have similar
pharmacological profile. Tagged receptors were shown by immunofluorescence to
be inserted in the plasma membrane. In undifferentiated cells the subcellular
localization of the two mGluR5 isoforms was partially segregated, whereas in differentiated
cells the labeling largely redistributed to the newly formed neurites. Interestingly,
we demonstrate that mGluR5 splice variants dramatically influence the formation
and maturation of neurites; mGluR5a hinders the acquisition of mature neuronal
traits and mGluR5b fosters the elaboration and extension of neurites. These effects
are partly inhibited by MPEP.
acknowledgement: "The authors thank: Dr. J. M. Rimland and M. T. Scupoli for their
technical help with X. oocytes recordings and FAC sorting, respectively; Dr. Y.
Dalezios for helping with the statistical analyses; and Dr. G. Varani for helping
with the analyses of mRNA and genomic sequences. We are also grateful to Professor
F. Benfenati, Dr. F. Conquet, Dr. Rafael Lujan, Dr. J. McIlhinney, Professor P.
Somogyi, Dr. J. H. Xuereb, and Dr. M. Zoli for careful reading of the manuscript\r\nand
helpful suggestions. R.S. is supported by the Laboratory of Cerebral Structure,
National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST
Japan Science and Technology Corporation, Japan."
article_processing_charge: No
article_type: original
author:
- first_name: Silvia
full_name: Mion, Silvia
last_name: Mion
- first_name: Corrado
full_name: Corti, Corrado
last_name: Corti
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Mauro
full_name: Corsi, Mauro
last_name: Corsi
- first_name: Guido
full_name: Fumagalli, Guido
last_name: Fumagalli
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Mion S, Corti C, Neki A, et al. Bidirectional regulation of neurite elaboration
by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms.
Molecular and Cellular Neuroscience. 2001;17(6):957-972. doi:10.1006/mcne.2001.0993
apa: Mion, S., Corti, C., Neki, A., Shigemoto, R., Corsi, M., Fumagalli, G., &
Ferraguti, F. (2001). Bidirectional regulation of neurite elaboration by alternatively
spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and
Cellular Neuroscience. Academic Press. https://doi.org/10.1006/mcne.2001.0993
chicago: Mion, Silvia, Corrado Corti, Akio Neki, Ryuichi Shigemoto, Mauro Corsi,
Guido Fumagalli, and Francesco Ferraguti. “Bidirectional Regulation of Neurite
Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5)
Isoforms.” Molecular and Cellular Neuroscience. Academic Press, 2001. https://doi.org/10.1006/mcne.2001.0993.
ieee: S. Mion et al., “Bidirectional regulation of neurite elaboration by
alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms,” Molecular
and Cellular Neuroscience, vol. 17, no. 6. Academic Press, pp. 957–972, 2001.
ista: Mion S, Corti C, Neki A, Shigemoto R, Corsi M, Fumagalli G, Ferraguti F. 2001.
Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 17(6),
957–972.
mla: Mion, Silvia, et al. “Bidirectional Regulation of Neurite Elaboration by Alternatively
Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” Molecular and
Cellular Neuroscience, vol. 17, no. 6, Academic Press, 2001, pp. 957–72, doi:10.1006/mcne.2001.0993.
short: S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti,
Molecular and Cellular Neuroscience 17 (2001) 957–972.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-24T09:34:13Z
day: '01'
doi: 10.1006/mcne.2001.0993
extern: '1'
external_id:
pmid:
- '11414786'
intvolume: ' 17'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 957 - 972
pmid: 1
publication: Molecular and Cellular Neuroscience
publication_identifier:
issn:
- 1044-7431
publication_status: published
publisher: Academic Press
publist_id: '4291'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '2605'
abstract:
- lang: eng
text: 'The granular layer of the cerebellar cortex consists of densely packed neuronal
cells, classified into granule cells and large interneurons. In this study, we
provide a comparative survey of large granular layer interneurons in the adult
rat cerebellum based on both morphological and neurochemical criteria. To this
end, double immunofluorescence histochemistry was performed by combining antibodies
against the cytoplasmic antigen Rat-303, calretinin, the metabotropic glutamate
receptor mGluR2 and somatostatin. Based on Rat-303/calretinin double immunohistochemistry,
three distinct populations of large granular layer interneurons could be discerned:
cells immunopositive for Rat-303, calretinin or both. Rat-303 or calretinin single-labeled
cells represented Golgi cells and unipolar brush cells, respectively. Rat-303/calretinin
double-labeled cells located just underneath the Purkinje cell layer represented
Lugaro cells. Morphometrical analysis distinguished two populations of Rat-303-positive
Golgi cells according to their location: vermis versus hemisphere. Immunostaining
for the metabotropic glutamate receptor mGluR2 combined with Rat-303 or calretinin
revealed that the majority of Golgi cells (about 90%) appeared to be mGluR2 positive.
Lugaro cells were mGluR2 negative. In addition, a limited population of large
polymorphous interneurons in the depth of the granular layer with morphological
features resembling Golgi cells also displayed Rat-303/calretinin immunoreactivity
and were mGluR2 negative. Double immunohistochemistry for Rat-303 and somatostatin
revealed three populations of labeled cells in the depth of the granular layer.
Besides double-labeled Golgi cells, Rat-303 or somatostatin single-labeled cells
were present. Based on mGluR2/somatostatin and calretinin/somatostatin double
immunostainings, Rat-303 single-labeled cells were found to correspond to Rat-303/calretinin-positive,
mGluR2-negative Golgi-like cells, while the identity of somatostatin single-labeled
cells remained unclear. The data presented in this article elaborate previous
reports on the morphological and neurochemical differentiation of large interneurons
in the rat cerebellar granular layer. In addition, they indicate that the current
classification of these cells into Golgi cells, Lugaro cells and unipolar brush
cells does not describe the observed neurochemical heterogeneity.'
article_processing_charge: No
article_type: original
author:
- first_name: Frederik
full_name: Geurts, Frederik
last_name: Geurts
- first_name: Jean
full_name: Timmermans, Jean
last_name: Timmermans
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Erik
full_name: De Schutter, Erik
last_name: De Schutter
citation:
ama: Geurts F, Timmermans J, Shigemoto R, De Schutter E. Morphological and neurochemical
differentiation of large granular layer interneurons in the adult rat cerebellum.
Neuroscience. 2001;104(2):499-512. doi:10.1016/S0306-4522(01)00058-6
apa: Geurts, F., Timmermans, J., Shigemoto, R., & De Schutter, E. (2001). Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00058-6
chicago: Geurts, Frederik, Jean Timmermans, Ryuichi Shigemoto, and Erik De Schutter.
“Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons
in the Adult Rat Cerebellum.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00058-6.
ieee: F. Geurts, J. Timmermans, R. Shigemoto, and E. De Schutter, “Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum,” Neuroscience, vol. 104, no. 2. Elsevier, pp. 499–512,
2001.
ista: Geurts F, Timmermans J, Shigemoto R, De Schutter E. 2001. Morphological and
neurochemical differentiation of large granular layer interneurons in the adult
rat cerebellum. Neuroscience. 104(2), 499–512.
mla: Geurts, Frederik, et al. “Morphological and Neurochemical Differentiation of
Large Granular Layer Interneurons in the Adult Rat Cerebellum.” Neuroscience,
vol. 104, no. 2, Elsevier, 2001, pp. 499–512, doi:10.1016/S0306-4522(01)00058-6.
short: F. Geurts, J. Timmermans, R. Shigemoto, E. De Schutter, Neuroscience 104
(2001) 499–512.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-05-10T00:00:00Z
date_updated: 2023-05-24T12:45:30Z
day: '10'
doi: 10.1016/S0306-4522(01)00058-6
extern: '1'
external_id:
pmid:
- '11377850'
intvolume: ' 104'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 499 - 512
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4292'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Morphological and neurochemical differentiation of large granular layer interneurons
in the adult rat cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 104
year: '2001'
...
---
_id: '2604'
abstract:
- lang: eng
text: Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena
that occur in neurogenic inflammation, are partially blocked by substance P (SP)
receptor antagonists and are known to be mediated in part by mast cell-released
substances, such as histamine, serotonin, and nitric oxide. In an attempt to provide
a morphological substrate for the above phenomena, we applied light and electron
microscopic immunocytochemistry to investigate the pattern of SP innervation of
blood vessels and its relationship to mast cells in the skin of the rat lower
lip. Furthermore, we examined the distribution of SP (neurokinin-1) receptors
and their relationship to SP-immunoreactive (IR) fibers. Our results confirmed
that SP-IR fibers are found in cutaneous nerves and that terminal branches are
observed around blood vessels and penetrating the epidermis. SP-IR fibers also
innervated hair follicles and sebaceous glands. At the ultrastructural level,
SP-IR varicosities were observed adjacent to arterioles, capillaries, venules,
and mast cells. The varicosities possessed both dense core vesicles and agranular
synaptic vesicles. We quantified the distance between SP-IR varicosities and blood
vessel endothelial cells. SP-IR terminals were located within 0.23-5.99 μm from
the endothelial cell layer in 82.7% of arterioles, in 90.2% of capillaries, and
in 86.9% of venules. Although there was a trend for SP-IR fibers to be located
closer to the endothelium of venules, this difference was not significant. Neurokinin-1
receptor (NK-1r) immunoreactivity was most abundant in the upper dermis and was
associated with the wall of blood vessels. NK-1r were located in equal amounts
on the walls of arterioles, capillaries, and venules that were innervated by SP-IR
fibers. The present results favor the concept of a participation of SP in cutaneous
neurogenic vasodilatation and plasma extravasation both by an action on blood
vessels after binding to the NK-1r and by causing the release of substances from
mast cells after diffusion through the connective tissue.
acknowledgement: This work was sponsored by grant MT-12170 from the Canadian Medical
Research Council. The authors thank Marie Ballak for electron microscopy assistance,
Alan Forster for photographic expertise, and Sid Parkinson for editorial
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Light and electron microscopic
study of the distribution of substance P-immunoreactive fibers and neurokinin-1
receptors in the skin of the rat lower lip. Journal of Comparative Neurology.
2001;432(4):466-480. doi:10.1002/cne.1114
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Light
and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal
of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.1114
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Light and Electron Microscopic Study of the Distribution of Substance
P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower
Lip.” Journal of Comparative Neurology. Wiley-Blackwell, 2001. https://doi.org/10.1002/cne.1114.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip,” Journal of Comparative
Neurology, vol. 432, no. 4. Wiley-Blackwell, pp. 466–480, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative
Neurology. 432(4), 466–480.
mla: Ruocco, Isabella, et al. “Light and Electron Microscopic Study of the Distribution
of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of
the Rat Lower Lip.” Journal of Comparative Neurology, vol. 432, no. 4,
Wiley-Blackwell, 2001, pp. 466–80, doi:10.1002/cne.1114.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Journal of Comparative
Neurology 432 (2001) 466–480.
date_created: 2018-12-11T11:58:37Z
date_published: 2001-04-16T00:00:00Z
date_updated: 2023-05-24T13:03:51Z
day: '16'
doi: 10.1002/cne.1114
extern: '1'
external_id:
pmid:
- '11268009'
intvolume: ' 432'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 466 - 480
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4294'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 432
year: '2001'
...
---
_id: '2606'
abstract:
- lang: eng
text: Glutamate receptors have been linked to the regulation of several developmental
events in the CNS. By using cortical slices of early postnatal mice, we show that
in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations
mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution
of mGluRs to these responses was demonstrated by application of tACPD, an agonist
to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly
blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular
Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs,
elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive
Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated
that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific
antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius
(Reelin-immunoreactive) neurons.
acknowledgement: MV and AF are senior coauthors of this work, which was supported by
Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to
M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial de R+D AE98-18 from Generalitat Valenciana, and a Fellowship
from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his G10 antireelin antibody and Roberto Gallego, Juan M. Luque and Felix
Viana for their constructive criticisms on previous versions of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Galán
full_name: Martínez, Galán
last_name: Martínez
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Miguel
full_name: Valdeolmillos, Miguel
last_name: Valdeolmillos
citation:
ama: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors. European Journal of Neuroscience. 2001;13(6):1147-1154.
doi:10.1046/j.0953-816X.2001.01494.x
apa: Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &
Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex
selectively express functional metabotropic glutamate receptors. European Journal
of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816X.2001.01494.x
chicago: Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto,
Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal
Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.”
European Journal of Neuroscience. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.0953-816X.2001.01494.x.
ieee: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos,
“Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors,” European Journal of Neuroscience, vol.
13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.
ista: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express
functional metabotropic glutamate receptors. European Journal of Neuroscience.
13(6), 1147–1154.
mla: Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex
Selectively Express Functional Metabotropic Glutamate Receptors.” European
Journal of Neuroscience, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54,
doi:10.1046/j.0953-816X.2001.01494.x.
short: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos,
European Journal of Neuroscience 13 (2001) 1147–1154.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-24T12:53:46Z
day: '01'
doi: 10.1046/j.0953-816X.2001.01494.x
extern: '1'
external_id:
pmid:
- '11285012'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 1147 - 1154
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4293'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...
---
_id: '2419'
abstract:
- lang: eng
text: For an absolutely continuous probability measure μ. on ℝd and a nonnegative
integer k, let S̃k(μ, 0) denote the probability that the convex hull of k + d
+ 1 random points which are i.i.d. according to μ contains the origin 0. For d
and k given, we determine a tight upper bound on S̃k(μ, 0), and we characterize
the measures in ℝd which attain this bound. As we will see, this result can be
considered a continuous analogue of the Upper Bound Theorem for the maximal number
of faces of convex polytopes with a given number of vertices. For our proof we
introduce so-called h-functions, continuous counterparts of h-vectors of simplicial
convex polytopes.
acknowledgement: We are indebted to Rolf Schneider for many helpful remarks and in
particular for bringing reference [6] to our attention
article_processing_charge: No
article_type: original
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Wagner U, Welzl E. A continuous analogue of the Upper Bound Theorem. Discrete
& Computational Geometry. 2001;26(2):205-219. doi:10.1007/s00454-001-0028-9
apa: Wagner, U., & Welzl, E. (2001). A continuous analogue of the Upper Bound
Theorem. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0028-9
chicago: Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.”
Discrete & Computational Geometry. Springer, 2001. https://doi.org/10.1007/s00454-001-0028-9.
ieee: U. Wagner and E. Welzl, “A continuous analogue of the Upper Bound Theorem,”
Discrete & Computational Geometry, vol. 26, no. 2. Springer, pp. 205–219,
2001.
ista: Wagner U, Welzl E. 2001. A continuous analogue of the Upper Bound Theorem.
Discrete & Computational Geometry. 26(2), 205–219.
mla: Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.”
Discrete & Computational Geometry, vol. 26, no. 2, Springer, 2001,
pp. 205–19, doi:10.1007/s00454-001-0028-9.
short: U. Wagner, E. Welzl, Discrete & Computational Geometry 26 (2001) 205–219.
date_created: 2018-12-11T11:57:33Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-24T13:13:51Z
day: '01'
doi: 10.1007/s00454-001-0028-9
extern: '1'
intvolume: ' 26'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 205 - 219
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '4506'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A continuous analogue of the Upper Bound Theorem
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 26
year: '2001'
...
---
_id: '2348'
abstract:
- lang: eng
text: This paper concerns the asymptotic ground state properties of heavy atoms
in strong, homogeneous magnetic fields. In the limit when the nuclear charge Z
tends to ∞ with the magnetic field B satisfying B ≫ Z4/3 all the electrons are
confined to the lowest Landau band. We consider here an energy functional, whose
variable is a sequence of one-dimensional density matrices corresponding to different
angular momentum functions in the lowest Landau band. We study this functional
in detail and derive various interesting properties, which are compared with the
density matrix (DM) theory introduced by Lieb, Solovej and Yngvason. In contrast
to the DM theory the variable perpendicular to the field is replaced by the discrete
angular momentum quantum numbers. Hence we call the new functional a discrete
density matrix (DDM) functional. We relate this DDM theory to the lowest Landau
band quantum mechanics and show that it reproduces correctly the ground state
energy apart from errors due to the indirect part of the Coulomb interaction energy.
acknowledgement: The authors would like to thank Bernhard Baumgartner and Jakob Yngvason
for proofreading and valuable comments.
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Seiringer R. A discrete density matrix theory for atoms in strong
magnetic fields. Communications in Mathematical Physics. 2001;217(1):229-248.
doi:10.1007/s002200100373
apa: Hainzl, C., & Seiringer, R. (2001). A discrete density matrix theory for
atoms in strong magnetic fields. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s002200100373
chicago: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory
for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics.
Springer, 2001. https://doi.org/10.1007/s002200100373.
ieee: C. Hainzl and R. Seiringer, “A discrete density matrix theory for atoms in
strong magnetic fields,” Communications in Mathematical Physics, vol. 217,
no. 1. Springer, pp. 229–248, 2001.
ista: Hainzl C, Seiringer R. 2001. A discrete density matrix theory for atoms in
strong magnetic fields. Communications in Mathematical Physics. 217(1), 229–248.
mla: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory
for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics,
vol. 217, no. 1, Springer, 2001, pp. 229–48, doi:10.1007/s002200100373.
short: C. Hainzl, R. Seiringer, Communications in Mathematical Physics 217 (2001)
229–248.
date_created: 2018-12-11T11:57:08Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-30T06:54:54Z
day: '01'
doi: 10.1007/s002200100373
extern: '1'
external_id:
arxiv:
- math-ph/0010005
intvolume: ' 217'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0010005
month: '02'
oa: 1
oa_version: Preprint
page: 229 - 248
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4578'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A discrete density matrix theory for atoms in strong magnetic fields
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 217
year: '2001'
...
---
_id: '2347'
abstract:
- lang: eng
text: We consider the ground state properties of an inhomogeneous two-dimensional
Bose gas with a repulsive, short range pair interaction and an external confining
potential. In the limit when the particle number N is large but ρ̅a 2 is small,
where ρ̅ is the average particle density and a the scattering length, the ground
state energy and density are rigorously shown to be given to leading order by
a Gross–Pitaevskii (GP) energy functional with a coupling constant g~1/|1n(ρ̅a
2)|. In contrast to the 3D case the coupling constant depends on N through the
mean density. The GP energy per particle depends only on Ng. In 2D this parameter
is typically so large that the gradient term in the GP energy functional is negligible
and the simpler description by a Thomas–Fermi type functional is adequate.
article_processing_charge: No
article_type: original
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: Lieb É, Seiringer R, Yngvason J. A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas. Communications in Mathematical
Physics. 2001;224(1):17-31. doi:10.1007/s002200100533
apa: Lieb, É., Seiringer, R., & Yngvason, J. (2001). A rigorous derivation of
the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications
in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100533
chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “A Rigorous Derivation
of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications
in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100533.
ieee: É. Lieb, R. Seiringer, and J. Yngvason, “A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas,” Communications in Mathematical
Physics, vol. 224, no. 1. Springer, pp. 17–31, 2001.
ista: Lieb É, Seiringer R, Yngvason J. 2001. A rigorous derivation of the Gross-Pitaevskii
energy functional for a two-dimensional Bose gas. Communications in Mathematical
Physics. 224(1), 17–31.
mla: Lieb, Élliott, et al. “A Rigorous Derivation of the Gross-Pitaevskii Energy
Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical
Physics, vol. 224, no. 1, Springer, 2001, pp. 17–31, doi:10.1007/s002200100533.
short: É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics
224 (2001) 17–31.
date_created: 2018-12-11T11:57:08Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-30T12:28:46Z
day: '01'
doi: 10.1007/s002200100533
extern: '1'
external_id:
arxiv:
- cond-mat/0005026
intvolume: ' 224'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/cond-mat/0005026
month: '11'
oa: 1
oa_version: Published Version
page: 17 - 31
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4579'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional
Bose gas
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 224
year: '2001'
...
---
_id: '2345'
abstract:
- lang: eng
text: We give upper bounds for the number of spin-1/2 particles that can be bound
to a nucleus of charge Z in the presence of a magnetic field B, including the
spin-field coupling. We use Lieb's strategy, which is known to yield Nc < 2Z
+ 1 for magnetic fields that go to zero at infinity, ignoring the spin-field interaction.
For particles with fermionic statistics in a homogeneous magnetic field our upper
bound has an additional term of the order of Z × min {(B/Z3)2/5, 1 + | 1n(B/Z3)|2}.
article_processing_charge: No
article_type: original
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Seiringer R. On the maximal ionization of atoms in strong magnetic fields.
Journal of Physics A: Mathematical and General. 2001;34(9):1943-1948. doi:10.1088/0305-4470/34/9/311'
apa: 'Seiringer, R. (2001). On the maximal ionization of atoms in strong magnetic
fields. Journal of Physics A: Mathematical and General. IOP Publishing
Ltd. https://doi.org/10.1088/0305-4470/34/9/311'
chicago: 'Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic
Fields.” Journal of Physics A: Mathematical and General. IOP Publishing
Ltd., 2001. https://doi.org/10.1088/0305-4470/34/9/311.'
ieee: 'R. Seiringer, “On the maximal ionization of atoms in strong magnetic fields,”
Journal of Physics A: Mathematical and General, vol. 34, no. 9. IOP Publishing
Ltd., pp. 1943–1948, 2001.'
ista: 'Seiringer R. 2001. On the maximal ionization of atoms in strong magnetic
fields. Journal of Physics A: Mathematical and General. 34(9), 1943–1948.'
mla: 'Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic
Fields.” Journal of Physics A: Mathematical and General, vol. 34, no. 9,
IOP Publishing Ltd., 2001, pp. 1943–48, doi:10.1088/0305-4470/34/9/311.'
short: 'R. Seiringer, Journal of Physics A: Mathematical and General 34 (2001) 1943–1948.'
date_created: 2018-12-11T11:57:07Z
date_published: 2001-03-09T00:00:00Z
date_updated: 2023-05-30T12:37:44Z
day: '09'
doi: 10.1088/0305-4470/34/9/311
extern: '1'
external_id:
arxiv:
- math-ph/0006002
intvolume: ' 34'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0006002
month: '03'
oa: 1
oa_version: None
page: 1943 - 1948
publication: 'Journal of Physics A: Mathematical and General'
publication_identifier:
issn:
- 0305-4470
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '4580'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the maximal ionization of atoms in strong magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 34
year: '2001'
...
---
_id: '2341'
abstract:
- lang: eng
text: We study the ground state properties of an atom with nuclear charge Z and
N bosonic "electrons" in the presence of a homogeneous magnetic field
B. We investigate the mean field limit N→∞ with N / Z fixed, and identify three
different asymptotic regions, according to B≪Z2,B∼Z2,andB≫Z2 . In Region 1 standard
Hartree theory is applicable. Region 3 is described by a one-dimensional functional,
which is identical to the so-called Hyper-Strong functional introduced by Lieb,
Solovej and Yngvason for atoms with fermionic electrons in the region B≫Z3 ; i.e.,
for very strong magnetic fields the ground state properties of atoms are independent
of statistics. For Region 2 we introduce a general magnetic Hartree functional,
which is studied in detail. It is shown that in the special case of an atom it
can be restricted to the subspace of zero angular momentum parallel to the magnetic
field, which simplifies the theory considerably. The functional reproduces the
energy and the one-particle reduced density matrix for the full N-particle ground
state to leading order in N, and it implies the description of the other regions
as limiting cases.
article_processing_charge: No
article_type: original
author:
- first_name: Bernhard
full_name: Baumgartner, Bernhard
last_name: Baumgartner
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Baumgartner B, Seiringer R. Atoms with bosonic "electrons"
in strong magnetic fields. Annales Henri Poincare. 2001;2(1):41-76. doi:10.1007/PL00001032
apa: Baumgartner, B., & Seiringer, R. (2001). Atoms with bosonic "electrons"
in strong magnetic fields. Annales Henri Poincare. Birkhäuser. https://doi.org/10.1007/PL00001032
chicago: Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic "Electrons"
in Strong Magnetic Fields.” Annales Henri Poincare. Birkhäuser, 2001. https://doi.org/10.1007/PL00001032.
ieee: B. Baumgartner and R. Seiringer, “Atoms with bosonic "electrons"
in strong magnetic fields,” Annales Henri Poincare, vol. 2, no. 1. Birkhäuser,
pp. 41–76, 2001.
ista: Baumgartner B, Seiringer R. 2001. Atoms with bosonic "electrons"
in strong magnetic fields. Annales Henri Poincare. 2(1), 41–76.
mla: Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic "Electrons"
in Strong Magnetic Fields.” Annales Henri Poincare, vol. 2, no. 1, Birkhäuser,
2001, pp. 41–76, doi:10.1007/PL00001032.
short: B. Baumgartner, R. Seiringer, Annales Henri Poincare 2 (2001) 41–76.
date_created: 2018-12-11T11:57:06Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-30T12:49:08Z
day: '01'
doi: 10.1007/PL00001032
extern: '1'
external_id:
arxiv:
- math-ph/0007007
intvolume: ' 2'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0007007
month: '02'
oa: 1
oa_version: None
page: 41 - 76
publication: Annales Henri Poincare
publication_identifier:
issn:
- 1424-0637
publication_status: published
publisher: Birkhäuser
publist_id: '4585'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Atoms with bosonic "electrons" in strong magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '2001'
...
---
_id: '2346'
abstract:
- lang: eng
text: By means of a generalization of the Fefferman - de la Llave decomposition
we derive a general lower bound on the interaction energy of one-dimensional quantum
systems. We apply this result to a specific class of lowest Landau band wave functions.
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Seiringer R. Bounds on one-dimensional exchange energies with application
to lowest Landau band quantum mechanics. Letters in Mathematical Physics.
2001;55(2):133-142. doi:10.1023/A:1010951905548
apa: Hainzl, C., & Seiringer, R. (2001). Bounds on one-dimensional exchange
energies with application to lowest Landau band quantum mechanics. Letters
in Mathematical Physics. Springer. https://doi.org/10.1023/A:1010951905548
chicago: Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange
Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters
in Mathematical Physics. Springer, 2001. https://doi.org/10.1023/A:1010951905548.
ieee: C. Hainzl and R. Seiringer, “Bounds on one-dimensional exchange energies with
application to lowest Landau band quantum mechanics,” Letters in Mathematical
Physics, vol. 55, no. 2. Springer, pp. 133–142, 2001.
ista: Hainzl C, Seiringer R. 2001. Bounds on one-dimensional exchange energies with
application to lowest Landau band quantum mechanics. Letters in Mathematical Physics.
55(2), 133–142.
mla: Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange
Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters
in Mathematical Physics, vol. 55, no. 2, Springer, 2001, pp. 133–42, doi:10.1023/A:1010951905548.
short: C. Hainzl, R. Seiringer, Letters in Mathematical Physics 55 (2001) 133–142.
date_created: 2018-12-11T11:57:07Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-30T12:44:05Z
day: '01'
doi: 10.1023/A:1010951905548
extern: '1'
external_id:
arxiv:
- cond-mat/0102118
intvolume: ' 55'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/cond-mat/0102118
month: '02'
oa: 1
oa_version: Published Version
page: 133 - 142
publication: Letters in Mathematical Physics
publication_identifier:
issn:
- 0377-9017
publication_status: published
publisher: Springer
publist_id: '4581'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bounds on one-dimensional exchange energies with application to lowest Landau
band quantum mechanics
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2001'
...
---
_id: '2340'
abstract:
- lang: eng
text: "Recent experimental breakthroughs in the treatment of dilute Bose gases have
renewed interest in their quantum mechanical description, respectively in approximations
to it. The ground state properties of dilute Bose gases confined in external potentials
and interacting via repulsive short range forces are usually described by means
of the Gross-Pitaevskii energy functional. In joint work with Elliott H. Lieb
and Jakob Yngvason its status as an approximation for the quantum mechanical many-body
ground state problem has recently been rigorously clarified. We present a summary
of this work, for both the two-and three-dimensional case.\r\n"
alternative_title:
- 'Operator Theory: Advances and Applications'
article_processing_charge: No
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Seiringer R. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii
ground state energy formula. In: Demuth M, Schultze B, eds. Vol 126. Birkhäuser;
2001:307-314. doi:10.1007/978-3-0348-8231-6'
apa: 'Seiringer, R. (2001). Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii
ground state energy formula. In M. Demuth & B. Schultze (Eds.) (Vol. 126,
pp. 307–314). Presented at the PDE: Partial Differential Equations and Spectral
Theory, Clausthal, Germany: Birkhäuser. https://doi.org/10.1007/978-3-0348-8231-6'
chicago: 'Seiringer, Robert. “Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii
Ground State Energy Formula.” edited by Michael Demuth and Bert Schultze, 126:307–14.
Birkhäuser, 2001. https://doi.org/10.1007/978-3-0348-8231-6.'
ieee: 'R. Seiringer, “Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii
ground state energy formula,” presented at the PDE: Partial Differential Equations
and Spectral Theory, Clausthal, Germany, 2001, vol. 126, pp. 307–314.'
ista: 'Seiringer R. 2001. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii
ground state energy formula. PDE: Partial Differential Equations and Spectral
Theory, Operator Theory: Advances and Applications, vol. 126, 307–314.'
mla: 'Seiringer, Robert. Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii
Ground State Energy Formula. Edited by Michael Demuth and Bert Schultze, vol.
126, Birkhäuser, 2001, pp. 307–14, doi:10.1007/978-3-0348-8231-6.'
short: R. Seiringer, in:, M. Demuth, B. Schultze (Eds.), Birkhäuser, 2001, pp. 307–314.
conference:
location: Clausthal, Germany
name: 'PDE: Partial Differential Equations and Spectral Theory'
date_created: 2018-12-11T11:57:05Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-30T13:20:05Z
day: '01'
doi: 10.1007/978-3-0348-8231-6
editor:
- first_name: Michael
full_name: Demuth, Michael
last_name: Demuth
- first_name: Bert
full_name: Schultze, Bert
last_name: Schultze
extern: '1'
external_id:
arxiv:
- math-ph/0010006
intvolume: ' 126'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0010006
month: '01'
oa: 1
oa_version: None
page: 307 - 314
publication_identifier:
isbn:
- '9783034894838'
publication_status: published
publisher: Birkhäuser
publist_id: '4586'
quality_controlled: '1'
status: public
title: 'Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state
energy formula'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 126
year: '2001'
...
---
_id: '1452'
abstract:
- lang: eng
text: 'In this Note we present pairs of hyperkähler orbifolds which satisfy two
different versions of mirror symmetry. On the one hand, we show that their Hodge
numbers (or more precisely, stringy E-polynomials) are equal. On the other hand,
we show that they satisfy the prescription of Strominger, Yau, and Zaslow (which
in the present case goes back to Bershadsky, Johansen, Sadov and Vafa): that a
Calabi-Yau and its mirror should fiber over the same real manifold, with special
Lagrangian fibers which are tori dual to each other. Our examples arise as moduli
spaces of local systems on a curve with structure group SL(n); the mirror is the
corresponding space with structure group PGL(n). The special Lagrangian tori come
from an algebraically completely integrable Hamiltonian system: the Hitchin system.'
acknowledgement: The authors are grateful for Nigel Hitchin for suggesting the similarity
between [4] and [12] in 1996 and for Pierre Deligne for numerous useful comments
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Michael
full_name: Thaddeus, Michael
last_name: Thaddeus
citation:
ama: 'Hausel T, Thaddeus M. Examples of mirror partners arising from integrable
systems. Comptes Rendus de l’Academie des Sciences - Series I: Mathematics.
2001;333(4):313-318. doi:10.1016/S0764-4442(01)02057-2'
apa: 'Hausel, T., & Thaddeus, M. (2001). Examples of mirror partners arising
from integrable systems. Comptes Rendus de l’Academie Des Sciences - Series
I: Mathematics. Elsevier. https://doi.org/10.1016/S0764-4442(01)02057-2'
chicago: 'Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising
from Integrable Systems.” Comptes Rendus de l’Academie Des Sciences - Series
I: Mathematics. Elsevier, 2001. https://doi.org/10.1016/S0764-4442(01)02057-2.'
ieee: 'T. Hausel and M. Thaddeus, “Examples of mirror partners arising from integrable
systems,” Comptes Rendus de l’Academie des Sciences - Series I: Mathematics,
vol. 333, no. 4. Elsevier, pp. 313–318, 2001.'
ista: 'Hausel T, Thaddeus M. 2001. Examples of mirror partners arising from integrable
systems. Comptes Rendus de l’Academie des Sciences - Series I: Mathematics. 333(4),
313–318.'
mla: 'Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising
from Integrable Systems.” Comptes Rendus de l’Academie Des Sciences - Series
I: Mathematics, vol. 333, no. 4, Elsevier, 2001, pp. 313–18, doi:10.1016/S0764-4442(01)02057-2.'
short: 'T. Hausel, M. Thaddeus, Comptes Rendus de l’Academie Des Sciences - Series
I: Mathematics 333 (2001) 313–318.'
date_created: 2018-12-11T11:52:06Z
date_published: 2001-08-15T00:00:00Z
date_updated: 2023-05-31T09:57:48Z
day: '15'
doi: 10.1016/S0764-4442(01)02057-2
extern: '1'
external_id:
arxiv:
- math/0106140
intvolume: ' 333'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/0106140
month: '08'
oa: 1
oa_version: Preprint
page: 313 - 318
publication: 'Comptes Rendus de l''Academie des Sciences - Series I: Mathematics'
publication_identifier:
issn:
- 0764-4442
publication_status: published
publisher: Elsevier
publist_id: '5742'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Examples of mirror partners arising from integrable systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 333
year: '2001'
...
---
_id: '888'
abstract:
- lang: eng
text: 'BACKGROUND: Detection of changes in a protein''s evolutionary rate may reveal
cases of change in that protein''s function. We developed and implemented a simple
relative rates test in an attempt to assess the rate constancy of protein evolution
and to detect cases of functional diversification between orthologous proteins.
The test was performed on clusters of orthologous protein sequences from complete
bacterial genomes (Chlamydia trachomatis, C. muridarum and Chlamydophila pneumoniae),
complete archaeal genomes (Pyrococcus horikoshii, P. abyssi and P. furiosus) and
partially sequenced mammalian genomes (human, mouse and rat). RESULTS: Amino-acid
sequence evolution rates are significantly correlated on different branches of
phylogenetic trees representing the great majority of analyzed orthologous protein
sets from all three domains of life. However, approximately 1% of the proteins
from each group of species deviates from this pattern and instead shows variation
that is consistent with an acceleration of the rate of amino-acid substitution,
which may be due to functional diversification. Most of the putative functionally
diversified proteins from all three species groups are predicted to function at
the periphery of the cells and mediate their interaction with the environment.
CONCLUSIONS: Relative rates of protein evolution are remarkably constant for the
three species groups analyzed here. Deviations from this rate constancy are probably
due to changes in selective constraints associated with diversification between
orthologs. Functional diversification between orthologs is thought to be a relatively
rare event. However, the resolution afforded by the test designed specifically
for genomic-scale datasets allowed us to identify numerous cases of possible functional
diversification between orthologous proteins.'
acknowledgement: We thank Alexey Kondrashov for many helpful discussions and constructive
criticisms, Charles DeLisi, David Landsman, Detlef Leipe, Wojciech Makalowski and
Itai Yanai for critical reading of the manuscript and constructive comments and
L. Aravind for advice on protein function prediction. The release of the unpublished
P. furiosus genome sequence by the Utah Genome Center at the University of Utah
is acknowledged and appreciated.
article_number: research0053.1
article_processing_charge: No
article_type: original
author:
- first_name: Ingo
full_name: Jordan, Ingo
last_name: Jordan
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Roman
full_name: Tatusov, Roman
last_name: Tatusov
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Jordan I, Kondrashov F, Rogozin I, Tatusov R, Wolf Y, Koonin E. Constant relative
rate of protein evolution and detection of functional diversification among bacterial,
archaeal and eukaryotic proteins . Genome Biology. 2001;2(12). doi:10.1186/gb-2001-2-12-research0053
apa: Jordan, I., Kondrashov, F., Rogozin, I., Tatusov, R., Wolf, Y., & Koonin,
E. (2001). Constant relative rate of protein evolution and detection of functional
diversification among bacterial, archaeal and eukaryotic proteins . Genome
Biology. BioMed Central. https://doi.org/10.1186/gb-2001-2-12-research0053
chicago: Jordan, Ingo, Fyodor Kondrashov, Igor Rogozin, Roman Tatusov, Yuri Wolf,
and Eugene Koonin. “Constant Relative Rate of Protein Evolution and Detection
of Functional Diversification among Bacterial, Archaeal and Eukaryotic Proteins
.” Genome Biology. BioMed Central, 2001. https://doi.org/10.1186/gb-2001-2-12-research0053.
ieee: I. Jordan, F. Kondrashov, I. Rogozin, R. Tatusov, Y. Wolf, and E. Koonin,
“Constant relative rate of protein evolution and detection of functional diversification
among bacterial, archaeal and eukaryotic proteins ,” Genome Biology, vol.
2, no. 12. BioMed Central, 2001.
ista: Jordan I, Kondrashov F, Rogozin I, Tatusov R, Wolf Y, Koonin E. 2001. Constant
relative rate of protein evolution and detection of functional diversification
among bacterial, archaeal and eukaryotic proteins . Genome Biology. 2(12), research0053.1.
mla: Jordan, Ingo, et al. “Constant Relative Rate of Protein Evolution and Detection
of Functional Diversification among Bacterial, Archaeal and Eukaryotic Proteins
.” Genome Biology, vol. 2, no. 12, research0053.1, BioMed Central, 2001,
doi:10.1186/gb-2001-2-12-research0053.
short: I. Jordan, F. Kondrashov, I. Rogozin, R. Tatusov, Y. Wolf, E. Koonin, Genome
Biology 2 (2001).
date_created: 2018-12-11T11:49:02Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-31T12:15:37Z
day: '01'
doi: 10.1186/gb-2001-2-12-research0053
extern: '1'
external_id:
pmid:
- '11790256'
intvolume: ' 2'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64838/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
issn:
- 1465-6906
publication_status: published
publisher: BioMed Central
publist_id: '6758'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Constant relative rate of protein evolution and detection of functional diversification
among bacterial, archaeal and eukaryotic proteins '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '2001'
...
---
_id: '1453'
abstract:
- lang: eng
text: In this Letter we exhibit a one-parameter family of new Taub-NUT instantons
parameterized by a half-line. The endpoint of the half-line will be the reducible
Yang-Mills instanton corresponding to the Eguchi-Hanson-Gibbons L2 harmonic 2-form,
while at an inner point we recover the Pope-Yuille instanton constructed as a
projection of the Levi-Civitá connection onto the positive su(2)+ ⊂ so(4) subalgebra.
Our method imitates the Jackiw-Nohl-Rebbi construction originally designed for
flat R4. That is we find a one-parameter family of harmonic functions on the Taub-NUT
space with a point singularity, rescale the metric and project the obtained Levi-Civitá
connection onto the other negative su(2)- ⊂ so(4) part. Our solutions will possess
the full U(2) symmetry, and thus provide more solutions to the recently proposed
U(2) symmetric ansatz of Kim and Yoon.
acknowledgement: We would like to acknowledge the financial support provided by the
Miller Institute of Basic Research in Science, the Japan Society for the Promotion
of Science, grant No. P99736 and the partial support by OTKA grant No. T032478.
article_processing_charge: No
article_type: original
author:
- first_name: Gábor
full_name: Etesi, Gábor
last_name: Etesi
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
citation:
ama: 'Etesi G, Hausel T. Geometric construction of new Yang-Mills instantons over
Taub-NUT space. Physics Letters, Section B: Nuclear, Elementary Particle and
High-Energy Physics. 2001;514(1-2):189-199. doi:10.1016/S0370-2693(01)00821-8'
apa: 'Etesi, G., & Hausel, T. (2001). Geometric construction of new Yang-Mills
instantons over Taub-NUT space. Physics Letters, Section B: Nuclear, Elementary
Particle and High-Energy Physics. Elsevier. https://doi.org/10.1016/S0370-2693(01)00821-8'
chicago: 'Etesi, Gábor, and Tamás Hausel. “Geometric Construction of New Yang-Mills
Instantons over Taub-NUT Space.” Physics Letters, Section B: Nuclear, Elementary
Particle and High-Energy Physics. Elsevier, 2001. https://doi.org/10.1016/S0370-2693(01)00821-8.'
ieee: 'G. Etesi and T. Hausel, “Geometric construction of new Yang-Mills instantons
over Taub-NUT space,” Physics Letters, Section B: Nuclear, Elementary Particle
and High-Energy Physics, vol. 514, no. 1–2. Elsevier, pp. 189–199, 2001.'
ista: 'Etesi G, Hausel T. 2001. Geometric construction of new Yang-Mills instantons
over Taub-NUT space. Physics Letters, Section B: Nuclear, Elementary Particle
and High-Energy Physics. 514(1–2), 189–199.'
mla: 'Etesi, Gábor, and Tamás Hausel. “Geometric Construction of New Yang-Mills
Instantons over Taub-NUT Space.” Physics Letters, Section B: Nuclear, Elementary
Particle and High-Energy Physics, vol. 514, no. 1–2, Elsevier, 2001, pp. 189–99,
doi:10.1016/S0370-2693(01)00821-8.'
short: 'G. Etesi, T. Hausel, Physics Letters, Section B: Nuclear, Elementary Particle
and High-Energy Physics 514 (2001) 189–199.'
date_created: 2018-12-11T11:52:07Z
date_published: 2001-08-09T00:00:00Z
date_updated: 2023-05-31T11:51:37Z
day: '09'
doi: 10.1016/S0370-2693(01)00821-8
extern: '1'
external_id:
arxiv:
- hep-th/0105118
intvolume: ' 514'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/hep-th/0105118
month: '08'
oa: 1
oa_version: Preprint
page: 189 - 199
publication: 'Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy
Physics'
publication_identifier:
issn:
- 0370-2693
publication_status: published
publisher: Elsevier
publist_id: '5743'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometric construction of new Yang-Mills instantons over Taub-NUT space
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 514
year: '2001'
...
---
_id: '1454'
abstract:
- lang: eng
text: We address the problem of finding Abelian instantons of finite energy on the
Euclidean Schwarzschild manifold. This amounts to construct self-dual L2 harmonic
2-forms on the space. Gibbons found a non-topological L2 harmonic form in the
Taub-NUT metric, leading to Abelian instantons with continuous energy. We imitate
his construction in the case of the Euclidean Schwarzschild manifold and find
a non-topological self-dual L2 harmonic 2-form on it. We show how this gives rise
to Abelian instantons and identify them with SU(2)-instantons of Pontryagin number
2n2 found by Charap and Duff in 1977. Using results of Dodziuk and Hitchin we
also calculate the full L2 harmonic space for the Euclidean Schwarzschild manifold.
acknowledgement: The work in this paper was done when Tamás Hausel visited the Yukawa
Institute of Kyoto University in February 2000. We are grateful for Prof. G.W. Gibbons
for insightful discussions and Prof. H. Kodama and the Yukawa Institute for the
invitation and hospitality.
article_processing_charge: No
article_type: original
author:
- first_name: Gábor
full_name: Etesi, Gábor
last_name: Etesi
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
citation:
ama: Etesi G, Hausel T. Geometric interpretation of Schwarzschild instantons. Journal
of Geometry and Physics. 2001;37(1-2):126-136. doi:10.1016/S0393-0440(00)00040-1
apa: Etesi, G., & Hausel, T. (2001). Geometric interpretation of Schwarzschild
instantons. Journal of Geometry and Physics. Elsevier. https://doi.org/10.1016/S0393-0440(00)00040-1
chicago: Etesi, Gábor, and Tamás Hausel. “Geometric Interpretation of Schwarzschild
Instantons.” Journal of Geometry and Physics. Elsevier, 2001. https://doi.org/10.1016/S0393-0440(00)00040-1.
ieee: G. Etesi and T. Hausel, “Geometric interpretation of Schwarzschild instantons,”
Journal of Geometry and Physics, vol. 37, no. 1–2. Elsevier, pp. 126–136,
2001.
ista: Etesi G, Hausel T. 2001. Geometric interpretation of Schwarzschild instantons.
Journal of Geometry and Physics. 37(1–2), 126–136.
mla: Etesi, Gábor, and Tamás Hausel. “Geometric Interpretation of Schwarzschild
Instantons.” Journal of Geometry and Physics, vol. 37, no. 1–2, Elsevier,
2001, pp. 126–36, doi:10.1016/S0393-0440(00)00040-1.
short: G. Etesi, T. Hausel, Journal of Geometry and Physics 37 (2001) 126–136.
date_created: 2018-12-11T11:52:07Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-31T12:08:45Z
day: '01'
doi: 10.1016/S0393-0440(00)00040-1
extern: '1'
external_id:
arxiv:
- hep-th/0003239
intvolume: ' 37'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/hep-th/0003239
month: '01'
oa: 1
oa_version: Preprint
page: 126 - 136
publication: Journal of Geometry and Physics
publication_identifier:
issn:
- 0393-0440
publication_status: published
publisher: Elsevier
publist_id: '5744'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometric interpretation of Schwarzschild instantons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 37
year: '2001'
...
---
_id: '855'
abstract:
- lang: eng
text: 'Motivation: The context of the start codon (typically, AUG) and the features
of the 5′ Untranslated Regions (5′ UTRs) are important for understanding translation
regulation in eukaryotic mRNAs and for accurate prediction of the coding region
in genomic and cDNA sequences. The presence of AUG triplets in 5′ UTRs (upstream
AUGs) might effect the initiation rate and, in the context of gene prediction,
could reduce the accuracy of the identification of the authentic start. To reveal
potential connections between the presence of upstream AUGs and other features
of 5′ UTRs, such as their length and the start codon context, we undertook a systematic
analysis of the available eukaryotic 5′ UTR sequences. Results: We show that a
large fraction of 5′ UTRs in the available cDNA sequences, 15-53% depending on
the organism, contain upstream ATGs. A negative correlation was observed between
the information content of the translation start signal and the length of the
5′ UTR. Similarly, a negative correlation exists between the ''strength'' of the
start context and the number of upstream ATGs. Typically, cDNAs containing long
5′ UTRs with multiple upstream ATGs have a ''weak'' start context, and in contrast,
cDNAs containing short 5′ UTRs without ATGs have ''strong'' starts. These counter-intuitive
results may be interpreted in terms of upstream AUGs having an important role
in the regulation of translation efficiency by ensuring low basal translation
level via double negative control and creating the potential for additional regulatory
mechanisms. One of such mechanisms, supported by experimental studies of some
mRNAs, includes removal of the AUG-containing portion of the 5′ UTR by alternative
splicing.'
acknowledgement: This work has been partially supported by EU 'TRADAT' project and
by CNR Genetic Engineering (Italy), the RFBR grant for support of scientific schools
(00-15-97968) and SD RAS grant for young scientists (AVK). The authors wish to thank
J.Lyons-Weiler for helpful comments and A. Sorokin for help with the ATG_EVALUATOR
program.
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Alex
full_name: Kochetov, Alex
last_name: Kochetov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
- first_name: Luciano
full_name: Milanesi, Luciano
last_name: Milanesi
citation:
ama: Rogozin I, Kochetov A, Kondrashov F, Koonin E, Milanesi L. Presence of ATG
triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a ’weak’context
of the start codon. Bioinformatics. 2001;17(10):890-900. doi:10.1093/bioinformatics/17.10.890
apa: Rogozin, I., Kochetov, A., Kondrashov, F., Koonin, E., & Milanesi, L. (2001).
Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates
with a ’weak’context of the start codon. Bioinformatics. Oxford University
Press. https://doi.org/10.1093/bioinformatics/17.10.890
chicago: Rogozin, Igor, Alex Kochetov, Fyodor Kondrashov, Eugene Koonin, and Luciano
Milanesi. “Presence of ATG Triplets in 5′ Untranslated Regions of Eukaryotic CDNAs
Correlates with a ’weak’context of the Start Codon.” Bioinformatics. Oxford
University Press, 2001. https://doi.org/10.1093/bioinformatics/17.10.890.
ieee: I. Rogozin, A. Kochetov, F. Kondrashov, E. Koonin, and L. Milanesi, “Presence
of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with
a ’weak’context of the start codon,” Bioinformatics, vol. 17, no. 10. Oxford
University Press, pp. 890–900, 2001.
ista: Rogozin I, Kochetov A, Kondrashov F, Koonin E, Milanesi L. 2001. Presence
of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with
a ’weak’context of the start codon. Bioinformatics. 17(10), 890–900.
mla: Rogozin, Igor, et al. “Presence of ATG Triplets in 5′ Untranslated Regions
of Eukaryotic CDNAs Correlates with a ’weak’context of the Start Codon.” Bioinformatics,
vol. 17, no. 10, Oxford University Press, 2001, pp. 890–900, doi:10.1093/bioinformatics/17.10.890.
short: I. Rogozin, A. Kochetov, F. Kondrashov, E. Koonin, L. Milanesi, Bioinformatics
17 (2001) 890–900.
date_created: 2018-12-11T11:48:52Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-06-02T09:08:25Z
day: '01'
doi: 10.1093/bioinformatics/17.10.890
extern: '1'
external_id:
pmid:
- '11673233'
intvolume: ' 17'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 890 - 900
pmid: 1
publication: Bioinformatics
publication_identifier:
issn:
- 1367-4803
publication_status: published
publisher: Oxford University Press
publist_id: '6795'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates
with a 'weak'context of the start codon
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '874'
abstract:
- lang: eng
text: Sex is thought to facilitate accumulation of initially rare beneficial mutations
by allowing simultaneous allele replacements at many loci. However, this advantage
of sex depends on a restrictive assumption that the fitness of a genotype is determined
by fitness potential, a single intermediate variable to which all loci contribute
additively, so that new alleles can accumulate in any order. Individual-based
simulations of sexual and asexual populations reveal that under generic selection,
sex often retards adaptive evolution. When new alleles are beneficial only if
they accumulate in a prescribed order, a sexual population may evolve two or more
times slower than an asexual population because only asexual reproduction allows
some overlap of successive allele replacements. Many other fitness surfaces lead
to an even greater disadvantage of sex. Thus, either sex exists in spite of its
impact on the rate of adaptive allele replacements, or natural fitness surfaces
have rather specific properties, at least at the scale of intrapopulation genetic
variability.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
citation:
ama: Kondrashov F, Kondrashov A. Multidimensional epistasis and the disadvantage
of sex. PNAS. 2001;98(21):12089-12092. doi:10.1073/pnas.211214298
apa: Kondrashov, F., & Kondrashov, A. (2001). Multidimensional epistasis and
the disadvantage of sex. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.211214298
chicago: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis
and the Disadvantage of Sex.” PNAS. National Academy of Sciences, 2001.
https://doi.org/10.1073/pnas.211214298.
ieee: F. Kondrashov and A. Kondrashov, “Multidimensional epistasis and the disadvantage
of sex,” PNAS, vol. 98, no. 21. National Academy of Sciences, pp. 12089–12092,
2001.
ista: Kondrashov F, Kondrashov A. 2001. Multidimensional epistasis and the disadvantage
of sex. PNAS. 98(21), 12089–12092.
mla: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis and
the Disadvantage of Sex.” PNAS, vol. 98, no. 21, National Academy of Sciences,
2001, pp. 12089–92, doi:10.1073/pnas.211214298.
short: F. Kondrashov, A. Kondrashov, PNAS 98 (2001) 12089–12092.
date_created: 2018-12-11T11:48:58Z
date_published: 2001-10-09T00:00:00Z
date_updated: 2023-06-02T08:18:22Z
day: '09'
doi: 10.1073/pnas.211214298
extern: '1'
external_id:
pmid:
- '11593020'
intvolume: ' 98'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59772/
month: '10'
oa: 1
oa_version: Published Version
page: 12089 - 12092
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '6774'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multidimensional epistasis and the disadvantage of sex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '867'
abstract:
- lang: eng
text: Genes with new functions often evolve by gene duplication. Alternative splicing
is another means of evolutionary innovation in eukaryotes, which allows a single
gene to encode functionally diverse proteins. We investigate a connection between
these two evolutionary phenomena. For ∼10% of the described cases of substitution
alternative splicing, such that either one or another amino acid sequence is included
into the protein, evidence of origin by tandem exon duplication was found. This
is a conservative estimate because alternative exons are typically short and,
on many occasions, duplicates may have diverged beyond recognition. Dating exon
duplications through a combination of the available experimental data on alternative
splicing in orthologous genes from different species and computational analysis
indicates that most of the duplications antedate at least the radiation of mammalian
orders or even the radiation of vertebrate classes. At present, tandem exon duplication
is the only mechanism of evolution of substitution alternative splicing that can
be specifically demonstrated. Along with gene duplication, this could be a major
route for generating functional diversity during evolution of multicellular eukaryotes.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Kondrashov F, Koonin E. Origin of alternative splicing by tandem exon duplication.
Human Molecular Genetics. 2001;10(23):2661-2669. doi:10.1093/hmg/10.23.2661
apa: Kondrashov, F., & Koonin, E. (2001). Origin of alternative splicing by
tandem exon duplication. Human Molecular Genetics. Oxford University Press.
https://doi.org/10.1093/hmg/10.23.2661
chicago: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing
by Tandem Exon Duplication.” Human Molecular Genetics. Oxford University
Press, 2001. https://doi.org/10.1093/hmg/10.23.2661.
ieee: F. Kondrashov and E. Koonin, “Origin of alternative splicing by tandem exon
duplication,” Human Molecular Genetics, vol. 10, no. 23. Oxford University
Press, pp. 2661–2669, 2001.
ista: Kondrashov F, Koonin E. 2001. Origin of alternative splicing by tandem exon
duplication. Human Molecular Genetics. 10(23), 2661–2669.
mla: Kondrashov, Fyodor, and Eugene Koonin. “Origin of Alternative Splicing by Tandem
Exon Duplication.” Human Molecular Genetics, vol. 10, no. 23, Oxford University
Press, 2001, pp. 2661–69, doi:10.1093/hmg/10.23.2661.
short: F. Kondrashov, E. Koonin, Human Molecular Genetics 10 (2001) 2661–2669.
date_created: 2018-12-11T11:48:55Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-06-02T08:39:47Z
day: '01'
doi: 10.1093/hmg/10.23.2661
extern: '1'
external_id:
pmid:
- '11726553'
intvolume: ' 10'
issue: '23'
language:
- iso: eng
month: '11'
oa_version: Published Version
page: 2661 - 2669
pmid: 1
publication: Human Molecular Genetics
publication_identifier:
issn:
- 0964-6906
publication_status: published
publisher: Oxford University Press
publist_id: '6777'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Origin of alternative splicing by tandem exon duplication
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2001'
...
---
_id: '851'
abstract:
- lang: eng
text: 'The study and comparison of mutation(al) spectra is an important problem
in molecular biology, because these spectra often reflect on important features
of mutations and their fixation. Such features include the interaction of DNA
with various mutagens, the function of repair/replication enzymes, and properties
of target proteins. It is known that mutability varies significantly along nucleotide
sequences, such that mutations often concentrate at certain positions, called
"hotspots," in a sequence. In this paper, we discuss in detail two approaches
for mutation spectra analysis: the comparison of mutation spectra with a HG-PUBL
program, (FTP: sunsite.unc.edu/pub/academic/ biology/dna-mutations/hyperg) and
hotspot prediction with the CLUSTERM program (www.itba.mi.cnr.it/webmutation;
ftp.bionet.nsc.ru/pub/biology/dbms/clusterm.zip). Several other approaches for
mutational spectra analysis, such as the analysis of a target protein structure,
hotspot context revealing, multiple spectra comparisons, as well as a number of
mutation databases are briefly described. Mutation spectra in the lacI gene of
E. coli and the human p53 gene are used for illustration of various difficulties
of such analysis.'
acknowledgement: 'Russian Fund of Fundamental Research. Grant Number: 99-04-49535.
NIH. Grant Number: GM 20293. NASA. Grant Number: NCC2-1057'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Galina
full_name: Glazko, Galina
last_name: Glazko
citation:
ama: Rogozin I, Kondrashov F, Glazko G. Use of mutation spectra analysis software.
Human Mutation. 2001;17(2):83-102. doi:10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
apa: Rogozin, I., Kondrashov, F., & Glazko, G. (2001). Use of mutation spectra
analysis software. Human Mutation. Wiley-Blackwell. https://doi.org/10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
chicago: Rogozin, Igor, Fyodor Kondrashov, and Galina Glazko. “Use of Mutation Spectra
Analysis Software.” Human Mutation. Wiley-Blackwell, 2001. https://doi.org/10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E.
ieee: I. Rogozin, F. Kondrashov, and G. Glazko, “Use of mutation spectra analysis
software,” Human Mutation, vol. 17, no. 2. Wiley-Blackwell, pp. 83–102,
2001.
ista: Rogozin I, Kondrashov F, Glazko G. 2001. Use of mutation spectra analysis
software. Human Mutation. 17(2), 83–102.
mla: Rogozin, Igor, et al. “Use of Mutation Spectra Analysis Software.” Human
Mutation, vol. 17, no. 2, Wiley-Blackwell, 2001, pp. 83–102, doi:10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E.
short: I. Rogozin, F. Kondrashov, G. Glazko, Human Mutation 17 (2001) 83–102.
date_created: 2018-12-11T11:48:50Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-06-02T09:22:17Z
day: '01'
doi: 10.1002/1098-1004(200102)17:2<83::AID-HUMU1>3.0.CO;2-E
extern: '1'
external_id:
pmid:
- '11180592'
intvolume: ' 17'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 83 - 102
pmid: 1
publication: Human Mutation
publication_identifier:
issn:
- 1059-7794
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6796'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Use of mutation spectra analysis software
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '841'
article_processing_charge: No
article_type: original
author:
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: 'Wolf Y, Kondrashov F, Koonin E. Footprints of primordial introns on the eukaryotic
genome: still no clear traces . Trends in Genetics. 2001;17(9):499-501.
doi:10.1016/S0168-9525(01)02376-9'
apa: 'Wolf, Y., Kondrashov, F., & Koonin, E. (2001). Footprints of primordial
introns on the eukaryotic genome: still no clear traces . Trends in Genetics.
Elsevier. https://doi.org/10.1016/S0168-9525(01)02376-9'
chicago: 'Wolf, Yuri, Fyodor Kondrashov, and Eugene Koonin. “Footprints of Primordial
Introns on the Eukaryotic Genome: Still No Clear Traces .” Trends in Genetics.
Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02376-9.'
ieee: 'Y. Wolf, F. Kondrashov, and E. Koonin, “Footprints of primordial introns
on the eukaryotic genome: still no clear traces ,” Trends in Genetics,
vol. 17, no. 9. Elsevier, pp. 499–501, 2001.'
ista: 'Wolf Y, Kondrashov F, Koonin E. 2001. Footprints of primordial introns on
the eukaryotic genome: still no clear traces . Trends in Genetics. 17(9), 499–501.'
mla: 'Wolf, Yuri, et al. “Footprints of Primordial Introns on the Eukaryotic Genome:
Still No Clear Traces .” Trends in Genetics, vol. 17, no. 9, Elsevier,
2001, pp. 499–501, doi:10.1016/S0168-9525(01)02376-9.'
short: Y. Wolf, F. Kondrashov, E. Koonin, Trends in Genetics 17 (2001) 499–501.
date_created: 2018-12-11T11:48:47Z
date_published: 2001-09-01T00:00:00Z
date_updated: 2023-06-02T09:38:37Z
day: '01'
doi: 10.1016/S0168-9525(01)02376-9
extern: '1'
external_id:
pmid:
- '11721681'
intvolume: ' 17'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 499 - 501
pmid: 1
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9479
publication_status: published
publisher: Elsevier
publist_id: '6805'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Footprints of primordial introns on the eukaryotic genome: still no clear
traces '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '11755'
abstract:
- lang: eng
text: Hyperlink analysis algorithms significantly improve the relevance of the search
results on the Web, so much so that all major Web search engines claim to use
some type of hyperlink analysis. However, the search engines do not disclose details
about the type of hyperlink analysis they perform, mostly to avoid manipulation
of search results by Web-positioning companies. The article discusses how hyperlink
analysis can be applied to ranking algorithms, and surveys other ways Web search
engines can use this analysis.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. Hyperlink analysis for the Web. IEEE Internet Computing.
2001;5(1):45-50. doi:10.1109/4236.895141
apa: Henzinger, M. H. (2001). Hyperlink analysis for the Web. IEEE Internet Computing.
Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/4236.895141
chicago: Henzinger, Monika H. “Hyperlink Analysis for the Web.” IEEE Internet
Computing. Institute of Electrical and Electronics Engineers, 2001. https://doi.org/10.1109/4236.895141.
ieee: M. H. Henzinger, “Hyperlink analysis for the Web,” IEEE Internet Computing,
vol. 5, no. 1. Institute of Electrical and Electronics Engineers, pp. 45–50, 2001.
ista: Henzinger MH. 2001. Hyperlink analysis for the Web. IEEE Internet Computing.
5(1), 45–50.
mla: Henzinger, Monika H. “Hyperlink Analysis for the Web.” IEEE Internet Computing,
vol. 5, no. 1, Institute of Electrical and Electronics Engineers, 2001, pp. 45–50,
doi:10.1109/4236.895141.
short: M.H. Henzinger, IEEE Internet Computing 5 (2001) 45–50.
date_created: 2022-08-08T10:51:43Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-08-03T12:45:55Z
day: '01'
doi: 10.1109/4236.895141
extern: '1'
external_id:
isi:
- '000744285600001'
intvolume: ' 5'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 45-50
publication: IEEE Internet Computing
publication_identifier:
eissn:
- 1941-0131
issn:
- 1089-7801
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hyperlink analysis for the Web
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2001'
...