[{"status":"public","article_type":"original","type":"journal_article","_id":"4264","extern":"1","date_updated":"2023-05-10T12:16:55Z","month":"07","intvolume":" 16","oa_version":"None","pmid":1,"abstract":[{"text":"The study of speciation has become one of the most active areas of evolutionary biology, and substantial progress has been made in documenting and understanding phenomena ranging from sympatric speciation and reinforcement to the evolutionary genetics of postzygotic isolation. This progress has been driven largely by empirical results, and most useful theoretical work has concentrated on making sense of empirical patterns. Given the complexity of speciation, mathematical theory is subordinate to verbal theory and generalizations about data. Nevertheless, mathematical theory can provide a useful classification of verbal theories; can help determine the biological plausibility of verbal theories; can determine whether alternative mechanisms of speciation are consistent with empirical patterns; and can occasionally provide predictions that go beyond empirical generalizations. We discuss recent examples of progress in each of these areas.","lang":"eng"}],"volume":16,"issue":"7","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0169-5347"]},"publication_status":"published","title":"Theory and speciation","publist_id":"1828","author":[{"first_name":"Michael","full_name":"Turelli, Michael","last_name":"Turelli"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"},{"full_name":"Coyne, Jerry","last_name":"Coyne","first_name":"Jerry"}],"external_id":{"pmid":["11403865"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Turelli, Michael, et al. “Theory and Speciation.” Trends in Ecology and Evolution, vol. 16, no. 7, Cell Press, 2001, pp. 330–43, doi:10.1016/S0169-5347(01)02177-2.","short":"M. Turelli, N.H. Barton, J. Coyne, Trends in Ecology and Evolution 16 (2001) 330–343.","ieee":"M. Turelli, N. H. Barton, and J. Coyne, “Theory and speciation,” Trends in Ecology and Evolution, vol. 16, no. 7. Cell Press, pp. 330–343, 2001.","apa":"Turelli, M., Barton, N. H., & Coyne, J. (2001). Theory and speciation. Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/S0169-5347(01)02177-2","ama":"Turelli M, Barton NH, Coyne J. Theory and speciation. Trends in Ecology and Evolution. 2001;16(7):330-343. doi:10.1016/S0169-5347(01)02177-2","chicago":"Turelli, Michael, Nicholas H Barton, and Jerry Coyne. “Theory and Speciation.” Trends in Ecology and Evolution. Cell Press, 2001. https://doi.org/10.1016/S0169-5347(01)02177-2.","ista":"Turelli M, Barton NH, Coyne J. 2001. Theory and speciation. Trends in Ecology and Evolution. 16(7), 330–343."},"quality_controlled":"1","publisher":"Cell Press","acknowledgement":"We thank D. Bolnick, B. Fitzpatrick, S. Gavrilets, R. Haygood, C.D. Jones, M. Kirkpatrick, A. Kondrashov, J.B. Mullet, S.V. Nuzhdin, H.A. Orr, T.D. Price, T. Prout, D.W. Schemske, D. Schluter, M.R. Servedio and P.S. Ward for discussion and comments. Some of these reviewers disagree with our conclusions. This work was supported by US National Science Foundation grants DEB 9527808 and DEB 0089716 to MT, grants from the Darwin Trust of Edinburgh and the Biotechnology and Biological Sciences Research Council (GRJ/76057, GR/H/09928) to NHB, and National Institutes of Health grant R01 GM58260 to JAC. ","date_published":"2001-07-01T00:00:00Z","doi":"10.1016/S0169-5347(01)02177-2","date_created":"2018-12-11T12:07:55Z","page":"330 - 343","day":"01","publication":"Trends in Ecology and Evolution","year":"2001"},{"_id":"4267","type":"book_chapter","status":"public","citation":{"ista":"Barton NH. 2001.Adaptation at the edge of a species’ range. In: Integrating ecology and evolution in a spatial context. , 365–392.","chicago":"Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” In Integrating Ecology and Evolution in a Spatial Context, 365–92. Cambridge University Press, 2001.","ieee":"N. H. Barton, “Adaptation at the edge of a species’ range,” in Integrating ecology and evolution in a spatial context, Cambridge University Press, 2001, pp. 365–392.","short":"N.H. Barton, in:, Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–392.","ama":"Barton NH. Adaptation at the edge of a species’ range. In: Integrating Ecology and Evolution in a Spatial Context. Cambridge University Press; 2001:365-392.","apa":"Barton, N. H. (2001). Adaptation at the edge of a species’ range. In Integrating ecology and evolution in a spatial context (pp. 365–392). Cambridge University Press.","mla":"Barton, Nicholas H. “Adaptation at the Edge of a Species’ Range.” Integrating Ecology and Evolution in a Spatial Context, Cambridge University Press, 2001, pp. 365–92."},"date_updated":"2023-05-10T11:59:06Z","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240"}],"publist_id":"1825","article_processing_charge":"No","title":"Adaptation at the edge of a species' range","abstract":[{"lang":"eng","text":"The flow of genes from the dense and well-adapted centre of a species' distribution interferes with adaptation to marginal environments, and may sharply limit a species' range. Deterministic models of a linear habitat suggest that populations could in principle adapt to very steep environmental gradients, by increasing their genetic variability. However, random fluctuations in sparse populations reduce this variance, and may be crucial in limiting the species' range."}],"oa_version":"None","publisher":"Cambridge University Press","quality_controlled":"1","main_file_link":[{"url":"https://www.cambridge.org/us/academic/subjects/life-sciences/ecology-and-conservation/integrating-ecology-and-evolution-spatial-context-14th-special-symposium-british-ecological-society?format=HB&isbn=9780521840002"}],"month":"08","publication_identifier":{"isbn":["9780521840002"]},"publication_status":"published","year":"2001","day":"01","language":[{"iso":"eng"}],"publication":"Integrating ecology and evolution in a spatial context","page":"365 - 392","date_published":"2001-08-01T00:00:00Z","date_created":"2018-12-11T12:07:57Z"},{"citation":{"chicago":"Cheng, Siu, Herbert Edelsbrunner, Ping Fu, and Ka Lam. “Design and Analysis of Planar Shape Deformation.” Computational Geometry: Theory and Applications. Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00020-7.","ista":"Cheng S, Edelsbrunner H, Fu P, Lam K. 2001. Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. 19(2–3), 205–218.","mla":"Cheng, Siu, et al. “Design and Analysis of Planar Shape Deformation.” Computational Geometry: Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 205–18, doi:10.1016/S0925-7721(01)00020-7.","ieee":"S. Cheng, H. Edelsbrunner, P. Fu, and K. Lam, “Design and analysis of planar shape deformation,” Computational Geometry: Theory and Applications, vol. 19, no. 2–3. Elsevier, pp. 205–218, 2001.","short":"S. Cheng, H. Edelsbrunner, P. Fu, K. Lam, Computational Geometry: Theory and Applications 19 (2001) 205–218.","apa":"Cheng, S., Edelsbrunner, H., Fu, P., & Lam, K. (2001). Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(01)00020-7","ama":"Cheng S, Edelsbrunner H, Fu P, Lam K. Design and analysis of planar shape deformation. Computational Geometry: Theory and Applications. 2001;19(2-3):205-218. doi:10.1016/S0925-7721(01)00020-7"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","publist_id":"2124","author":[{"last_name":"Cheng","full_name":"Cheng, Siu","first_name":"Siu"},{"first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner"},{"last_name":"Fu","full_name":"Fu, Ping","first_name":"Ping"},{"first_name":"Ka","last_name":"Lam","full_name":"Lam, Ka"}],"title":"Design and analysis of planar shape deformation","acknowledgement":"NSF under grants CCR-96-19542 and CCR-97-12088.","publisher":"Elsevier","quality_controlled":"1","year":"2001","publication":"Computational Geometry: Theory and Applications","day":"01","page":"205 - 218","date_created":"2018-12-11T12:06:22Z","doi":"10.1016/S0925-7721(01)00020-7","date_published":"2001-07-01T00:00:00Z","_id":"4002","type":"journal_article","article_type":"original","status":"public","date_updated":"2023-05-10T14:21:31Z","extern":"1","abstract":[{"lang":"eng","text":"Shape deformation refers to the continuous change of one geometric object to another. We develop a software tool for planning, analyzing and visualizing deformations between two shapes in R-2. The deformation is generated automatically without any user intervention or specification of feature correspondences. A unique property of the tool is the explicit availability of a two-dimensional shape space, which can be used for designing the deformation either automatically by following constraints and objectives or manually by drawing deformation paths."}],"oa_version":"None","scopus_import":"1","intvolume":" 19","month":"07","publication_status":"published","publication_identifier":{"issn":["0925-7721"]},"language":[{"iso":"eng"}],"issue":"2-3","volume":19},{"extern":"1","date_updated":"2023-05-10T12:57:14Z","status":"public","article_type":"original","type":"journal_article","_id":"4001","volume":19,"issue":"2-3","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0925-7721"]},"intvolume":" 19","month":"07","scopus_import":"1","oa_version":"None","abstract":[{"lang":"eng","text":"The construction of shape spaces is studied from a mathematical and a computational viewpoint. A program is outlined reducing the problem to four tasks: the representation of geometry, the canonical deformation of geometry, the measuring of distance in shape space, and the selection of base shapes. The technical part of this paper focuses on the second task: the specification of a deformation mixing two or more shapes in continuously changing proportions. (C) 2001 Elsevier Science B.V All rights reserved."}],"title":"Shape space from deformation","article_processing_charge":"No","publist_id":"2123","author":[{"last_name":"Cheng","full_name":"Cheng, Ho","first_name":"Ho"},{"first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"full_name":"Fu, Ping","last_name":"Fu","first_name":"Ping"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ama":"Cheng H, Edelsbrunner H, Fu P. Shape space from deformation. Computational Geometry: Theory and Applications. 2001;19(2-3):191-204. doi:10.1016/S0925-7721(01)00021-9","apa":"Cheng, H., Edelsbrunner, H., & Fu, P. (2001). Shape space from deformation. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/S0925-7721(01)00021-9","ieee":"H. Cheng, H. Edelsbrunner, and P. Fu, “Shape space from deformation,” Computational Geometry: Theory and Applications, vol. 19, no. 2–3. Elsevier, pp. 191–204, 2001.","short":"H. Cheng, H. Edelsbrunner, P. Fu, Computational Geometry: Theory and Applications 19 (2001) 191–204.","mla":"Cheng, Ho, et al. “Shape Space from Deformation.” Computational Geometry: Theory and Applications, vol. 19, no. 2–3, Elsevier, 2001, pp. 191–204, doi:10.1016/S0925-7721(01)00021-9.","ista":"Cheng H, Edelsbrunner H, Fu P. 2001. Shape space from deformation. Computational Geometry: Theory and Applications. 19(2–3), 191–204.","chicago":"Cheng, Ho, Herbert Edelsbrunner, and Ping Fu. “Shape Space from Deformation.” Computational Geometry: Theory and Applications. Elsevier, 2001. https://doi.org/10.1016/S0925-7721(01)00021-9."},"date_created":"2018-12-11T12:06:22Z","doi":"10.1016/S0925-7721(01)00021-9","date_published":"2001-07-01T00:00:00Z","page":"191 - 204","publication":"Computational Geometry: Theory and Applications","day":"01","year":"2001","publisher":"Elsevier","quality_controlled":"1","acknowledgement":"National Science Foundation under grants CCR-96-19542 and CCR-97-12088, and by the Army Research Office under grant DAAG55-98-1-0177."},{"date_updated":"2023-05-10T12:35:44Z","citation":{"ama":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. In: Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms. SIAM; 2001:47-56.","apa":"Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin triangulation. In Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms (pp. 47–56). Washington, DC, USA : SIAM.","ieee":"H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” in Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms, Washington, DC, USA , 2001, pp. 47–56.","short":"H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, in:, Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56.","mla":"Cheng, Ho, et al. “Dynamic Skin Triangulation.” Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2001, pp. 47–56.","ista":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms. SODA: Symposium on Discrete Algorithms, 47–56.","chicago":"Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” In Proceedings of the 12th Annual ACM-SIAM Symposium on Discrete Algorithms, 47–56. SIAM, 2001."},"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"first_name":"Ho","last_name":"Cheng","full_name":"Cheng, Ho"},{"last_name":"Dey","full_name":"Dey, Tamal","first_name":"Tamal"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner"},{"full_name":"Sullivan, John","last_name":"Sullivan","first_name":"John"}],"publist_id":"2120","article_processing_charge":"No","title":"Dynamic skin triangulation","_id":"4005","type":"conference","conference":{"name":"SODA: Symposium on Discrete Algorithms","start_date":"2001-01-07","end_date":"2001-01-09","location":"Washington, DC, USA "},"status":"public","publication_identifier":{"isbn":["9780898714906"]},"year":"2001","publication_status":"published","day":"09","language":[{"iso":"eng"}],"publication":"Proceedings of the 12th annual ACM-SIAM symposium on Discrete algorithms","page":"47 - 56","date_published":"2001-01-09T00:00:00Z","date_created":"2018-12-11T12:06:23Z","abstract":[{"text":"This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R-3. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface.","lang":"eng"}],"oa_version":"None","publisher":"SIAM","quality_controlled":"1","main_file_link":[{"url":"https://dl.acm.org/doi/10.5555/365411.365418"}],"month":"01"},{"acknowledgement":"NSF under grant DMS- 98-73945, ARO under grant DAAG55-98-1-0177, NSF under grants CCR-96- 19542 and CCR-97-12088.","publisher":"Springer","quality_controlled":"1","year":"2001","day":"04","publication":"Discrete & Computational Geometry","page":"525 - 568","date_published":"2001-04-04T00:00:00Z","doi":"10.1007/s00454-001-0007-1","date_created":"2018-12-11T12:06:24Z","citation":{"mla":"Cheng, Ho, et al. “Dynamic Skin Triangulation.” Discrete & Computational Geometry, vol. 25, no. 4, Springer, 2001, pp. 525–68, doi:10.1007/s00454-001-0007-1.","ama":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. Dynamic skin triangulation. Discrete & Computational Geometry. 2001;25(4):525-568. doi:10.1007/s00454-001-0007-1","apa":"Cheng, H., Dey, T., Edelsbrunner, H., & Sullivan, J. (2001). Dynamic skin triangulation. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0007-1","short":"H. Cheng, T. Dey, H. Edelsbrunner, J. Sullivan, Discrete & Computational Geometry 25 (2001) 525–568.","ieee":"H. Cheng, T. Dey, H. Edelsbrunner, and J. Sullivan, “Dynamic skin triangulation,” Discrete & Computational Geometry, vol. 25, no. 4. Springer, pp. 525–568, 2001.","chicago":"Cheng, Ho, Tamal Dey, Herbert Edelsbrunner, and John Sullivan. “Dynamic Skin Triangulation.” Discrete & Computational Geometry. Springer, 2001. https://doi.org/10.1007/s00454-001-0007-1.","ista":"Cheng H, Dey T, Edelsbrunner H, Sullivan J. 2001. Dynamic skin triangulation. Discrete & Computational Geometry. 25(4), 525–568."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"2122","author":[{"last_name":"Cheng","full_name":"Cheng, Ho","first_name":"Ho"},{"first_name":"Tamal","full_name":"Dey, Tamal","last_name":"Dey"},{"last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"John","last_name":"Sullivan","full_name":"Sullivan, John"}],"article_processing_charge":"No","title":"Dynamic skin triangulation","abstract":[{"text":"This paper describes an algorithm for maintaining an approximating triangulation of a deforming surface in R 3 . The surface is the envelope of an infinite family of spheres defined and controlled by a finite collection of weighted points. The triangulation adapts dynamically to changing shape, curvature, and topology of the surface. ","lang":"eng"}],"oa_version":"None","scopus_import":"1","month":"04","intvolume":" 25","publication_identifier":{"issn":["0179-5376"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"4","volume":25,"_id":"4007","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-10T12:45:59Z","extern":"1"},{"publisher":"Springer","quality_controlled":"1","intvolume":" 7","month":"05","abstract":[{"text":"The 180 models collected in this paper are produced by sampling and wrapping point sets on tubes. The surfaces are represented as triangulated 2-manifolds and available as st1-files from the author's web site at www.cs.duke.edu/similar toedels. Each tube is obtained by thickening a circle or a smooth torus knot, and for some we use the degrees of freedom in the thickening process to encode meaningful information, such as curvature or torsion.","lang":"eng"}],"oa_version":"None","page":"379 - 399","date_created":"2018-12-11T12:06:24Z","volume":7,"issue":"5","date_published":"2001-05-28T00:00:00Z","doi":"10.3217/jucs-007-05-0379","year":"2001","publication_status":"published","publication_identifier":{"issn":["0948-695X"]},"language":[{"iso":"eng"}],"publication":"Journal of Universal Computer Science","day":"28","type":"journal_article","article_type":"original","status":"public","_id":"4006","article_processing_charge":"No","author":[{"last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"2121","title":"180 wrapped tubes","date_updated":"2023-05-10T12:39:54Z","citation":{"ista":"Edelsbrunner H. 2001. 180 wrapped tubes. Journal of Universal Computer Science. 7(5), 379–399.","chicago":"Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer Science. Springer, 2001. https://doi.org/10.3217/jucs-007-05-0379.","short":"H. Edelsbrunner, Journal of Universal Computer Science 7 (2001) 379–399.","ieee":"H. Edelsbrunner, “180 wrapped tubes,” Journal of Universal Computer Science, vol. 7, no. 5. Springer, pp. 379–399, 2001.","apa":"Edelsbrunner, H. (2001). 180 wrapped tubes. Journal of Universal Computer Science. Springer. https://doi.org/10.3217/jucs-007-05-0379","ama":"Edelsbrunner H. 180 wrapped tubes. Journal of Universal Computer Science. 2001;7(5):379-399. doi:10.3217/jucs-007-05-0379","mla":"Edelsbrunner, Herbert. “180 Wrapped Tubes.” Journal of Universal Computer Science, vol. 7, no. 5, Springer, 2001, pp. 379–99, doi:10.3217/jucs-007-05-0379."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1"},{"issue":"22","volume":276,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9258"]},"publication_status":"published","month":"06","intvolume":" 276","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0021925819670134?via%3Dihub"}],"pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Regulated adhesion of leukocytes to the extracellular matrix is essential for transmigration of blood vessels and subsequent migration into the stroma of inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)- and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion to and migration on extracellular matrix molecules of the endothelial cell basement membrane and subjacent interstitial matrix. Mouse wild type and beta(2)-integrin null PMN and the progranulocytic cell line 32DC13 were employed in in vitro adhesion and migration assays using extracellular matrix molecules expressed at sites of extravasation in vivo, in particular the endothelial cell laminins 8 and 10. Wild type and beta(2)-integrin null PMN showed the same pattern of ECM binding, indicating that beta(2)-integrins do not mediate specific adhesion of PMN to the extracellular matrix molecules tested; binding was observed to the interstitial matrix molecules, fibronectin and vitronectin, via integrins alpha(5)beta(1) and alpha(v)beta(3), respectively; to laminin 10 via alpha(6)beta(1); but not to laminins 1, 2, and 8, collagen type I and IV, perlecan, or tenascin-C. PMN binding to laminins 1, 2, and 8 could not be induced despite surface expression of functionally active integrin alpha(6)beta(1), a major laminin receptor, demonstrating that expression of alpha(6)beta(1) alone is insufficient for ligand binding and suggesting the involvement of accessory factors. Nevertheless, laminins 1, 8, and 10 supported PMN migration, indicating that differential cellular signaling via laminins is independent of the extent of adhesion. The data demonstrate that adhesive and nonadhesive interactions with components of the endothelial cell basement membrane and subjacent interstitium play decisive roles in controlling PMN movement into sites of inflammation and illustrate that beta(2)-integrins are not essential for such interactions."}],"extern":"1","date_updated":"2023-05-11T12:54:06Z","status":"public","article_type":"original","type":"journal_article","_id":"3928","doi":"10.1074/jbc.M010898200","date_published":"2001-06-01T00:00:00Z","date_created":"2018-12-11T12:05:56Z","page":"18878 - 18887","day":"01","publication":"Journal of Biological Chemistry","year":"2001","publisher":"American Society for Biochemistry and Molecular Biology","quality_controlled":"1","oa":1,"acknowledgement":"We thank Dr. T. Winkler for carrying out flow cytometry analysis, Dr. Simon Goodman for providing cyclic RGD peptides and helpful discussions, and Stefanie Karosi and Thomas Samson for critical review of the manuscript. This work would not have been possible without the expert technical assistance of Friederike Pausch.","title":"Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation","publist_id":"2199","author":[{"last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Rupert","full_name":"Hallmann, Rupert","last_name":"Hallmann"},{"last_name":"Wendler","full_name":"Wendler, Olaf","first_name":"Olaf"},{"first_name":"Karin","last_name":"Scharffetter Kochanek","full_name":"Scharffetter Kochanek, Karin"},{"first_name":"Lydia","full_name":"Sorokin, Lydia","last_name":"Sorokin"}],"external_id":{"pmid":["11278780"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Sixt, Michael K, Rupert Hallmann, Olaf Wendler, Karin Scharffetter Kochanek, and Lydia Sorokin. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2001. https://doi.org/10.1074/jbc.M010898200.","ista":"Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. 2001. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 276(22), 18878–18887.","mla":"Sixt, Michael K., et al. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry, vol. 276, no. 22, American Society for Biochemistry and Molecular Biology, 2001, pp. 18878–87, doi:10.1074/jbc.M010898200.","ieee":"M. K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, and L. Sorokin, “Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation,” Journal of Biological Chemistry, vol. 276, no. 22. American Society for Biochemistry and Molecular Biology, pp. 18878–18887, 2001.","short":"M.K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, L. Sorokin, Journal of Biological Chemistry 276 (2001) 18878–18887.","apa":"Sixt, M. K., Hallmann, R., Wendler, O., Scharffetter Kochanek, K., & Sorokin, L. (2001). Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M010898200","ama":"Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 2001;276(22):18878-18887. doi:10.1074/jbc.M010898200"}},{"publication_status":"published","publication_identifier":{"issn":["0022-1767"]},"language":[{"iso":"eng"}],"volume":166,"issue":"2","abstract":[{"lang":"eng","text":"TNF-alpha has been clearly identified as central mediator of T cell activation-induced acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We show in this report that the hepatic TNFRs are not transcriptionally regulated, but are regulated by receptor shedding. TNF directly mediates hepatocellular death by activation of TNFR1 but also induces the expression of inflammatory proteins, such as cytokines and adhesion molecules. Here we provide evidence that resistance of TNFR1(-/-) and TNFR2(-/-) mice against Con A hepatitis is not due to an impaired production of the central mediators TNF and IFN-gamma. Con A injection results in a massive induction of ICAM-1, VCAM-1, and E-selectin in the liver. Lack of either one of both TNFRs did not change adhesion molecule expression in the livers of Con A-treated mice, presumably reflecting the fact that other endothelial cell-activating cytokines up-regulated adhesion molecule expression. However, treatment of TNFR1(-/-) and TNFR2(-/-) mice with murine rTNF revealed a predominant role for TNFR1 for the induction of hepatic adhesion molecule expression. Pretreatment with blocking Abs against E- and P-selectin or of ICAM(-/-) mice with anti-VCAM-1 Abs failed to prevent Con A hepatitis, although accumulation of the critical cell population, i.e., CD4(+) T cells was significantly inhibited. Hence, up-regulation of adhesion molecules during acute hepatitis unlikely contributes to organ injury but rather represents a defense mechanism."}],"pmid":1,"oa_version":"None","main_file_link":[{"url":"http://www.jimmunol.org/content/166/2/1300.long","open_access":"1"}],"intvolume":" 166","month":"01","date_updated":"2023-05-11T13:37:29Z","extern":"1","_id":"3927","article_type":"original","type":"journal_article","status":"public","year":"2001","publication":"Journal of Immunology","day":"15","page":"1300 - 1307","date_created":"2018-12-11T12:05:56Z","date_published":"2001-01-15T00:00:00Z","doi":"10.4049/jimmunol.166.2.1300","acknowledgement":"We thank Dr. H. Bluethmann (F. Hoffmann-LaRoche AG, Basle, Switzerland) for kindly providing us TNFR knockout mice. We are indebted to Dr. G. R. Adolf (Bender & Co Vienna, Austria) for providing recombinant murine TNF. We are also indebted to Dr. D. Vestweber for providing anti-P-selectin mAb (23). We thank Dr. W. Neuhuber (Institute of Anatomy, University of Erlangen-NÜrnberg, Erlangen, Germany) for experimental support regarding confocal laser scanning microscopy. The perfect technical assistance of Andrea Agli is gratefully acknowledged.","oa":1,"quality_controlled":"1","publisher":"American Association of Immunologists","citation":{"mla":"Wolf, Dominik, et al. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology, vol. 166, no. 2, American Association of Immunologists, 2001, pp. 1300–07, doi:10.4049/jimmunol.166.2.1300.","apa":"Wolf, D., Hallmann, R., Sass, G., Sixt, M. K., Küsters, S., Fregien, B., … Tiegs, G. (2001). TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. American Association of Immunologists. https://doi.org/10.4049/jimmunol.166.2.1300","ama":"Wolf D, Hallmann R, Sass G, et al. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 2001;166(2):1300-1307. doi:10.4049/jimmunol.166.2.1300","short":"D. Wolf, R. Hallmann, G. Sass, M.K. Sixt, S. Küsters, B. Fregien, C. Trautwein, G. Tiegs, Journal of Immunology 166 (2001) 1300–1307.","ieee":"D. Wolf et al., “TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis,” Journal of Immunology, vol. 166, no. 2. American Association of Immunologists, pp. 1300–1307, 2001.","chicago":"Wolf, Dominik, Rupert Hallmann, Gabriele Sass, Michael K Sixt, Sabine Küsters, Bastian Fregien, Christian Trautwein, and Gisa Tiegs. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology. American Association of Immunologists, 2001. https://doi.org/10.4049/jimmunol.166.2.1300.","ista":"Wolf D, Hallmann R, Sass G, Sixt MK, Küsters S, Fregien B, Trautwein C, Tiegs G. 2001. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 166(2), 1300–1307."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["11145713"]},"article_processing_charge":"No","publist_id":"2200","author":[{"first_name":"Dominik","full_name":"Wolf, Dominik","last_name":"Wolf"},{"full_name":"Hallmann, Rupert","last_name":"Hallmann","first_name":"Rupert"},{"first_name":"Gabriele","full_name":"Sass, Gabriele","last_name":"Sass"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179"},{"first_name":"Sabine","last_name":"Küsters","full_name":"Küsters, Sabine"},{"full_name":"Fregien, Bastian","last_name":"Fregien","first_name":"Bastian"},{"last_name":"Trautwein","full_name":"Trautwein, Christian","first_name":"Christian"},{"last_name":"Tiegs","full_name":"Tiegs, Gisa","first_name":"Gisa"}],"title":"TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis"},{"scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174323/","open_access":"1"}],"month":"05","intvolume":" 153","abstract":[{"text":"An active involvement of blood-brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extravasating T lymphocytes during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their expression was influenced by proinflammatory cytokines or angiostatic agents. T cells emigrating into the CNS during EAE encountered two biochemically distinct basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal (containing laminins 1 and 2) basement membranes. However, inflammatory cuffs occurred exclusively around endothelial basement membranes containing laminin 8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and 10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus a high turnover of laminin 8 at these sites, suggested two possible roles for laminin 8 in the endothelial basement membrane: one at the level of the endothelial cells resulting in reduced adhesion and, thereby, increased penetrability of the monolayer; and secondly at the level of the T cells providing direct signals to the transmigrating cells.","lang":"eng"}],"pmid":1,"oa_version":"Published Version","volume":153,"issue":"5","publication_identifier":{"issn":["0021-9525"]},"publication_status":"published","language":[{"iso":"eng"}],"type":"journal_article","article_type":"original","status":"public","_id":"3930","date_updated":"2023-05-11T12:19:36Z","extern":"1","publisher":"Rockefeller University Press","quality_controlled":"1","oa":1,"acknowledgement":"The authors thank Stefanie Karosi for careful and critical reading of the manuscript and Monika Bruckner for expert technical assistance. We are particularly grateful to Winfried Neuhuber for help with confocal microscopy and interpretation of the data. This work was supported by Deutsche Forschungsgemeinschaft grants So285/1-3 and So285/1-4 to L.M. Sorokin.","page":"933 - 946","date_published":"2001-05-21T00:00:00Z","doi":"10.1083/jcb.153.5.933 ","date_created":"2018-12-11T12:05:57Z","year":"2001","day":"21","publication":"Journal of Cell Biology","publist_id":"2198","author":[{"full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Engelhardt, Britta","last_name":"Engelhardt","first_name":"Britta"},{"full_name":"Pausch, Friederike","last_name":"Pausch","first_name":"Friederike"},{"first_name":"Rupert","full_name":"Hallmann, Rupert","last_name":"Hallmann"},{"first_name":"Olaf","full_name":"Wendler, Olaf","last_name":"Wendler"},{"first_name":"Lydia","full_name":"Sorokin, Lydia","last_name":"Sorokin"}],"external_id":{"pmid":["11381080"]},"article_processing_charge":"No","title":"Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis","citation":{"mla":"Sixt, Michael K., et al. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology, vol. 153, no. 5, Rockefeller University Press, 2001, pp. 933–46, doi:10.1083/jcb.153.5.933 .","ama":"Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 2001;153(5):933-946. doi:10.1083/jcb.153.5.933 ","apa":"Sixt, M. K., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin, L. (2001). Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.153.5.933 ","ieee":"M. K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, and L. Sorokin, “Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis,” Journal of Cell Biology, vol. 153, no. 5. Rockefeller University Press, pp. 933–946, 2001.","short":"M.K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L. Sorokin, Journal of Cell Biology 153 (2001) 933–946.","chicago":"Sixt, Michael K, Britta Engelhardt, Friederike Pausch, Rupert Hallmann, Olaf Wendler, and Lydia Sorokin. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology. Rockefeller University Press, 2001. https://doi.org/10.1083/jcb.153.5.933 .","ista":"Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. 2001. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 153(5), 933–946."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"The extent of genetic variation in fitness and its components and genetic variation's dependence on environmental conditions remain key issues in evolutionary biology. We present measurements of genetic variation in preadult viability in a laboratory-adapted population of Drosophila melanogaster, made at four different densities. By crossing flies heterozygous for a wild-type chromosome and one of two different balancers (TM1, TM2), we measure both heterozygous (TM1/+, TM2/+) and homozygous (+/+) viability relative to a standard genotype (TM1/TM2). Forty wild-type chromosomes were tested, of which 10 were chosen to be homozygous viable. The mean numbers produced varied significantly between chromosome lines, with an estimated between-line variance in loge numbers of 0.013. Relative viabilities also varied significantly across chromosome lines, with a variance in loge homozygous viability of 1.76 and of loge heterozygous viability of 0.165. The between-line variance for numbers emerging increased with density, from 0.009 at lowest density to 0.079 at highest. The genetic variance in relative viability increases with density, but not significantly. Overall, the effects of different chromosomes on relative viability were remarkably consistent across densities and across the two heterozygous genotypes (TM1, TM2). The 10 lines that carried homozygous viable wild-type chromosomes produced significantly more adults than the 30 lethal lines at low density and significantly fewer adults at the highest density. Similarly, there was a positive correlation between heterozygous viability and mean numbers at low density, but a negative correlation at high density."}],"intvolume":" 55","month":"08","main_file_link":[{"url":"http://www.jstor.org/stable/2680379"}],"scopus_import":"1","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0014-3820"]},"issue":"8","volume":55,"_id":"3622","status":"public","article_type":"original","type":"journal_article","extern":"1","date_updated":"2023-05-11T13:43:30Z","acknowledgement":"We thank SERC and BBSRC for financial support and R.Miah, G. Geddes, and E. Garcia for technical assistance.","publisher":"Wiley-Blackwell","quality_controlled":"1","publication":"Evolution","day":"01","year":"2001","date_created":"2018-12-11T12:04:18Z","date_published":"2001-08-01T00:00:00Z","doi":"10.1111/j.0014-3820.2001.tb00680.x","page":"1609 - 1620","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Gardner, Michael, Kevin Fowler, Linda Patridge, and Nicholas H Barton. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution. Wiley-Blackwell, 2001. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x.","ista":"Gardner M, Fowler K, Patridge L, Barton NH. 2001. Genetic variation for preadult viability in Drosophila melanogaster. Evolution. 55(8), 1609–1620.","mla":"Gardner, Michael, et al. “Genetic Variation for Preadult Viability in Drosophila Melanogaster.” Evolution, vol. 55, no. 8, Wiley-Blackwell, 2001, pp. 1609–20, doi:10.1111/j.0014-3820.2001.tb00680.x.","ieee":"M. Gardner, K. Fowler, L. Patridge, and N. H. Barton, “Genetic variation for preadult viability in Drosophila melanogaster,” Evolution, vol. 55, no. 8. Wiley-Blackwell, pp. 1609–1620, 2001.","short":"M. Gardner, K. Fowler, L. Patridge, N.H. Barton, Evolution 55 (2001) 1609–1620.","apa":"Gardner, M., Fowler, K., Patridge, L., & Barton, N. H. (2001). Genetic variation for preadult viability in Drosophila melanogaster. Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2001.tb00680.x","ama":"Gardner M, Fowler K, Patridge L, Barton NH. Genetic variation for preadult viability in Drosophila melanogaster. Evolution. 2001;55(8):1609-1620. doi:10.1111/j.0014-3820.2001.tb00680.x"},"title":"Genetic variation for preadult viability in Drosophila melanogaster","external_id":{"pmid":["11580020"]},"article_processing_charge":"No","author":[{"last_name":"Gardner","full_name":"Gardner, Michael","first_name":"Michael"},{"full_name":"Fowler, Kevin","last_name":"Fowler","first_name":"Kevin"},{"full_name":"Patridge, Linda","last_name":"Patridge","first_name":"Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"publist_id":"2761"},{"date_updated":"2023-05-11T13:50:32Z","citation":{"ista":"Barton NH. 2001. Mendel and mathematics. Trends in Genetics. 17, 420–420.","chicago":"Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics. Elsevier, 2001. https://doi.org/10.1016/S0168-9525(01)02315-0.","short":"N.H. Barton, Trends in Genetics 17 (2001) 420–420.","ieee":"N. H. Barton, “Mendel and mathematics,” Trends in Genetics, vol. 17. Elsevier, pp. 420–420, 2001.","ama":"Barton NH. Mendel and mathematics. Trends in Genetics. 2001;17:420-420. doi:10.1016/S0168-9525(01)02315-0","apa":"Barton, N. H. (2001). Mendel and mathematics. Trends in Genetics. Elsevier. https://doi.org/10.1016/S0168-9525(01)02315-0","mla":"Barton, Nicholas H. “Mendel and Mathematics.” Trends in Genetics, vol. 17, Elsevier, 2001, pp. 420–420, doi:10.1016/S0168-9525(01)02315-0."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","article_processing_charge":"No","author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"2787","title":"Mendel and mathematics","_id":"3596","type":"review","status":"public","year":"2001","publication_status":"published","publication_identifier":{"issn":["0168-9479"]},"publication":"Trends in Genetics","language":[{"iso":"eng"}],"day":"01","page":"420 - 420","date_created":"2018-12-11T12:04:09Z","volume":17,"date_published":"2001-07-01T00:00:00Z","doi":"10.1016/S0168-9525(01)02315-0","oa_version":"None","publisher":"Elsevier","quality_controlled":"1","intvolume":" 17","month":"07"},{"date_updated":"2023-05-12T09:47:39Z","extern":"1","_id":"3546","article_type":"original","type":"journal_article","status":"public","publication_identifier":{"issn":["0270-6474"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"10","volume":21,"abstract":[{"lang":"eng","text":"Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 <mu>m) pyramidal neurons compared with distant (>300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors."}],"oa_version":"Published Version","pmid":1,"scopus_import":"1","main_file_link":[{"url":"https://pubmed.ncbi.nlm.nih.gov/11319243/","open_access":"1"}],"month":"05","intvolume":" 21","citation":{"short":"H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal of Neuroscience 21 (2001).","ieee":"H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent states of the hippocampal network affect functional clustering of neurons,” Journal of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001.","apa":"Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G. (2001). Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001","ama":"Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001","mla":"Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol. 21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001.","ista":"Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 21(10).","chicago":"Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"last_name":"Hirase","full_name":"Hirase, Hajima","first_name":"Hajima"},{"first_name":"Xavier","last_name":"Leinekugel","full_name":"Leinekugel, Xavier"},{"last_name":"Csicsvari","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Czurkó","full_name":"Czurkó, András","first_name":"András"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"publist_id":"2839","external_id":{"pmid":["11319243"]},"article_processing_charge":"No","title":"Behavior-dependent states of the hippocampal network affect functional clustering of neurons","year":"2001","day":"15","publication":"Journal of Neuroscience","doi":"10.1523/JNEUROSCI.21-10-j0003.2001","date_published":"2001-05-15T00:00:00Z","date_created":"2018-12-11T12:03:54Z","quality_controlled":"1","publisher":"Society for Neuroscience","oa":1},{"volume":98,"issue":"16","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0027-8424"]},"publication_status":"published","month":"07","intvolume":" 98","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/","open_access":"1"}],"oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng","text":"What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Hero we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-steep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered."}],"extern":"1","date_updated":"2023-05-12T10:07:41Z","status":"public","article_type":"original","type":"journal_article","_id":"3540","date_published":"2001-07-31T00:00:00Z","doi":"10.1073/pnas.161274398","date_created":"2018-12-11T12:03:52Z","page":"9386 - 9390","day":"31","publication":"PNAS","year":"2001","publisher":"National Academy of Sciences","quality_controlled":"1","oa":1,"acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.), and the Uehara Memorial Foundation (H.H.).","title":"Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience","publist_id":"2846","author":[{"first_name":"Hajima","full_name":"Hirase, Hajima","last_name":"Hirase"},{"first_name":"Xavier","full_name":"Leinekugel, Xavier","last_name":"Leinekugel"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"}],"external_id":{"pmid":["11470910"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ama":"Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398","apa":"Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (2001). Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.161274398","ieee":"H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy of Sciences, pp. 9386–9390, 2001.","short":"H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98 (2001) 9386–9390.","mla":"Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS, vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398.","ista":"Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 98(16), 9386–9390.","chicago":"Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398."}},{"day":"15","publication":"Journal of Neuroscience","year":"2001","date_published":"2001-04-15T00:00:00Z","doi":"10.1523/JNEUROSCI.21-08-02687.2001","date_created":"2018-12-11T12:03:37Z","page":"2687 - 2698","acknowledgement":"This work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B). We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical assistance.","publisher":"Society for Neuroscience","quality_controlled":"1","oa":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001.","short":"M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience 21 (2001) 2687–2698.","ieee":"M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001.","apa":"Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001). Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001","ama":"Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001","chicago":"Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001.","ista":"Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 21(8), 2687–2698."},"title":"Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.","author":[{"first_name":"Marlene","last_name":"Bartos","full_name":"Bartos, Marlene"},{"full_name":"Vida, Imre","last_name":"Vida","first_name":"Imre"},{"first_name":"Michael","last_name":"Frotscher","full_name":"Frotscher, Michael"},{"first_name":"Jörg","full_name":"Geiger, Jörg","last_name":"Geiger"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"publist_id":"2893","external_id":{"pmid":["11306622"]},"article_processing_charge":"No","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"publication_status":"published","issue":"8","volume":21,"oa_version":"Published Version","pmid":1,"abstract":[{"text":"Mutual synaptic interactions between GABAergic interneurons are thought to be of critical importance for the generation of network oscillations and for temporal encoding of information in the hippocampus. However, the functional properties of synaptic transmission between hippocampal interneurons are largely unknown. We have made paired recordings from basket cells (BCs) in the dentate gyrus of rat hippocampal slices, followed by correlated light and electron microscopical analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2 msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression (PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression during repetitive stimulation. Detailed passive cable model simulations based on somatodendritic morphology and localization of synaptic contacts further indicated that the conductance change at the postsynaptic site was even faster, decaying with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed that the decay time course of IPSCs at BC–BC synapses was approximately twofold faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable. To examine the consequences of the fast postsynaptic conductance change for the generation of oscillatory activity, we developed a computational model of an interneuron network. The model showed robust oscillations at frequencies >60 Hz if the excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron synapses may promote the generation of high-frequency oscillations observed in the dentate gyrusin vivo. ","lang":"eng"}],"month":"04","intvolume":" 21","main_file_link":[{"url":"ncbi.nlm.nih.gov/pmc/articles/PMC6762544/","open_access":"1"}],"extern":"1","date_updated":"2023-05-15T13:47:04Z","_id":"3494","status":"public","type":"journal_article","article_type":"original"},{"scopus_import":"1","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64746/"}],"month":"12","intvolume":" 98","abstract":[{"text":"The mossy fiber-CA3 pyramidal neuron synapse is a main component of the hippocampal trisynaptic circuitry. Recent studies, however, suggested that inhibitory interneurons are the major targets of the mossy fiber system. To study the regulation of mossy fiber-interneuron excitation, we examined unitary and compound excitatory postsynaptic currents in dentate gyrus basket cells, evoked by paired recording between granule and basket cells or extracellular stimulation of mossy fiber collaterals. The application of an associative high-frequency stimulation paradigm induced posttetanic potentiation (PTP) followed by homosynaptic long-term potentiation (LTP). Analysis of numbers of failures, coefficient of variation, and paired-pulse modulation indicated that both PTP and LTP were expressed presynaptically. The Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) did not affect PTP or LTP at a concentration of 10 mM but attenuated LTP at a concentration of 30 mM. Both forskolin, an adenylyl cyclase activator, and phorbolester diacetate, a protein kinase C stimulator, lead to a long-lasting increase in excitatory postsynaptic current amplitude. H-89, a protein kinase A inhibitor, and bisindolylmaleimide, a protein kinase C antagonist, reduced PTP, whereas only bisindolylmaleimide reduced LTP. These results may suggest a differential contribution of protein kinase A and C pathways to mossy fiber-interneuron plasticity. Interneuron PTP and LTP may provide mechanisms to maintain the balance between synaptic excitation of interneurons and that of principal neurons in the dentate gyrus-CA3 network. ","lang":"eng"}],"pmid":1,"oa_version":"None","volume":98,"issue":"25","publication_identifier":{"issn":["0027-8424"]},"publication_status":"published","language":[{"iso":"eng"}],"article_type":"original","type":"journal_article","status":"public","_id":"3496","date_updated":"2023-05-15T11:08:08Z","extern":"1","quality_controlled":"1","publisher":"National Academy of Sciences","oa":1,"acknowledgement":"We thank Drs. J. Bischofberger and M. Martina for critically reading an earlier version of the manuscript and A. Blomenkamp for excellent technical assistance. Supported by the Deutsche Forschungsgemeinschaft Sonderforschungsbereich 505/C5 and Human Frontiers Science Program Organization Grant RG0017/98.","page":"14708 - 14713","date_published":"2001-12-04T00:00:00Z","doi":"10.1073/pnas.251610898 ","date_created":"2018-12-11T12:03:38Z","year":"2001","day":"04","publication":"PNAS","publist_id":"2891","author":[{"first_name":"Henrik","full_name":"Alle, Henrik","last_name":"Alle"},{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"},{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"}],"external_id":{"pmid":["11734656"]},"article_processing_charge":"No","title":"PTP and LTP at a hippocampal mossy fiber-interneuron synapse","citation":{"ista":"Alle H, Jonas PM, Geiger J. 2001. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. 98(25), 14708–14713.","chicago":"Alle, Henrik, Peter M Jonas, and Jörg Geiger. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.251610898 .","short":"H. Alle, P.M. Jonas, J. Geiger, PNAS 98 (2001) 14708–14713.","ieee":"H. Alle, P. M. Jonas, and J. Geiger, “PTP and LTP at a hippocampal mossy fiber-interneuron synapse,” PNAS, vol. 98, no. 25. National Academy of Sciences, pp. 14708–14713, 2001.","apa":"Alle, H., Jonas, P. M., & Geiger, J. (2001). PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.251610898 ","ama":"Alle H, Jonas PM, Geiger J. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. 2001;98(25):14708-14713. doi:10.1073/pnas.251610898 ","mla":"Alle, Henrik, et al. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” PNAS, vol. 98, no. 25, National Academy of Sciences, 2001, pp. 14708–13, doi:10.1073/pnas.251610898 ."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"page":"96 - 104","date_created":"2018-12-11T12:03:38Z","date_published":"2001-10-19T00:00:00Z","doi":"10.1016/S0169-328X(01)00221-2","year":"2001","publication":"Molecular Brain Research","day":"19","publisher":"Elsevier","quality_controlled":"1","acknowledgement":"This work was supported in part by grants from the 358 (1992) 36–41.Deutsche Forschungsgemeinschaft (Bi 642 / 1-2) and the Volkswagen foundation. ","external_id":{"pmid":["11597769"]},"article_processing_charge":"No","author":[{"last_name":"Jerecic","full_name":"Jerecic, Jasna","first_name":"Jasna"},{"first_name":"Christian","last_name":"Schulze","full_name":"Schulze, Christian"},{"first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"},{"first_name":"Rolf","full_name":"Sprengel, Rolf","last_name":"Sprengel"},{"full_name":"Seeburg, Peter","last_name":"Seeburg","first_name":"Peter"},{"full_name":"Bischofberger, Joseph","last_name":"Bischofberger","first_name":"Joseph"}],"publist_id":"2892","title":"Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression","citation":{"apa":"Jerecic, J., Schulze, C., Jonas, P. M., Sprengel, R., Seeburg, P., & Bischofberger, J. (2001). Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Molecular Brain Research. Elsevier. https://doi.org/10.1016/S0169-328X(01)00221-2","ama":"Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Molecular Brain Research. 2001;94(1-2):96-104. doi:10.1016/S0169-328X(01)00221-2","ieee":"J. Jerecic, C. Schulze, P. M. Jonas, R. Sprengel, P. Seeburg, and J. Bischofberger, “Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression,” Molecular Brain Research, vol. 94, no. 1–2. Elsevier, pp. 96–104, 2001.","short":"J. Jerecic, C. Schulze, P.M. Jonas, R. Sprengel, P. Seeburg, J. Bischofberger, Molecular Brain Research 94 (2001) 96–104.","mla":"Jerecic, Jasna, et al. “Impaired NMDA Receptor Function in Mouse Olfactory Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” Molecular Brain Research, vol. 94, no. 1–2, Elsevier, 2001, pp. 96–104, doi:10.1016/S0169-328X(01)00221-2.","ista":"Jerecic J, Schulze C, Jonas PM, Sprengel R, Seeburg P, Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Molecular Brain Research. 94(1–2), 96–104.","chicago":"Jerecic, Jasna, Christian Schulze, Peter M Jonas, Rolf Sprengel, Peter Seeburg, and Joseph Bischofberger. “Impaired NMDA Receptor Function in Mouse Olfactory Bulb Neurons by Tetracycline-Sensitive NR1 (N598R) Expression.” Molecular Brain Research. Elsevier, 2001. https://doi.org/10.1016/S0169-328X(01)00221-2."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","volume":94,"issue":"1-2","publication_status":"published","publication_identifier":{"issn":["0169-328X"]},"language":[{"iso":"eng"}],"scopus_import":"1","intvolume":" 94","month":"10","abstract":[{"text":"High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598. NR1(R) expression from a single allele in gene-targeted NR1+/R mice is lethal soon after birth, precluding analysis of altered synaptic functions later in life. We therefore employed the forebrain specific αCaMKII promoter to drive tTA-mediated tetracyclin sensitive transcription of transgenes for NR1(R) and for lacZ as reporter. Transgene expression was observed in cortex, striatum, hippocampus, amygdala and olfactory bulb and was mosaic in all these forebrain regions. It was highest in olfactory bulb granule cells, in most of which Ca2+ permeability and voltage-dependent Mg2+ block of NMDA receptors were reduced to different extents. This indicates significant impairment of NMDA receptor function by NR1(R) in presence of the wild-type NR1 complement. Indeed, even though NR1(R) mRNA constituted only 18% of the entire NR1 mRNA population in forebrain, the transgenic mice died during adolescence unless transgene expression was suppressed by doxycycline. Thus, glutamate receptor function can be altered in the mouse by regulated NR1(R) transgene expression.","lang":"eng"}],"oa_version":"None","pmid":1,"date_updated":"2023-05-15T13:42:32Z","extern":"1","article_type":"original","type":"journal_article","status":"public","_id":"3495"},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Szabo, Imre, et al. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods, vol. 105, no. 1, Elsevier, 2001, pp. 105–10, doi:10.1016/S0165-0270(00)00362-9.","short":"I. Szabo, A. Czurkó, J.L. Csicsvari, H. Hirase, X. Leinekugel, G. Buzsáki, Journal of Neuroscience Methods 105 (2001) 105–110.","ieee":"I. Szabo, A. Czurkó, J. L. Csicsvari, H. Hirase, X. Leinekugel, and G. Buzsáki, “The application of printed circuit board technology for fabrication of multi-channel micro-drives,” Journal of Neuroscience Methods, vol. 105, no. 1. Elsevier, pp. 105–110, 2001.","apa":"Szabo, I., Czurkó, A., Csicsvari, J. L., Hirase, H., Leinekugel, X., & Buzsáki, G. (2001). The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. Elsevier. https://doi.org/10.1016/S0165-0270(00)00362-9","ama":"Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. 2001;105(1):105-110. doi:10.1016/S0165-0270(00)00362-9","chicago":"Szabo, Imre, András Czurkó, Jozsef L Csicsvari, Hajima Hirase, Xavier Leinekugel, and György Buzsáki. “The Application of Printed Circuit Board Technology for Fabrication of Multi-Channel Micro-Drives.” Journal of Neuroscience Methods. Elsevier, 2001. https://doi.org/10.1016/S0165-0270(00)00362-9.","ista":"Szabo I, Czurkó A, Csicsvari JL, Hirase H, Leinekugel X, Buzsáki G. 2001. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods. 105(1), 105–110."},"title":"The application of printed circuit board technology for fabrication of multi-channel micro-drives","article_processing_charge":"No","external_id":{"pmid":["11166371"]},"author":[{"full_name":"Szabo, Imre","last_name":"Szabo","first_name":"Imre"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L"},{"last_name":"Hirase","full_name":"Hirase, Hajima","first_name":"Hajima"},{"first_name":"Xavier","last_name":"Leinekugel","full_name":"Leinekugel, Xavier"},{"first_name":"György","last_name":"Buzsáki","full_name":"Buzsáki, György"}],"publist_id":"2868","publication":"Journal of Neuroscience Methods","day":"30","year":"2001","date_created":"2018-12-11T12:03:45Z","doi":"10.1016/S0165-0270(00)00362-9","date_published":"2001-01-30T00:00:00Z","page":"105 - 110","quality_controlled":"1","publisher":"Elsevier","extern":"1","date_updated":"2023-05-15T10:50:39Z","_id":"3517","status":"public","article_type":"original","type":"journal_article","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0165-0270"]},"volume":105,"issue":"1","pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"A modular multichannel microdrive ('hyperdrive') is described. The microdrive uses printed circuit board technology and flexible fused silica capillaries. The modular design allows for the fabrication of 4-32 independently movable electrodes or `tetrodes'. The drives are re-usable and re-loading the drive with electrodes is simple. "}],"intvolume":" 105","month":"01","scopus_import":"1"},{"issue":"5","volume":81,"publication_status":"published","publication_identifier":{"issn":["0006-3495"]},"language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301733/"}],"intvolume":" 81","month":"11","abstract":[{"text":"Although agonists and competitive antagonists presumably occupy overlapping binding sites on ligand-gated channels, these interactions cannot be identical because agonists cause channel opening whereas antagonists do not. One explanation is that only agonist binding performs enough work on the receptor to cause the conformational changes that lead to gating. This idea is supported by agonist binding rates at GABAA and nicotinic acetylcholine receptors that are slower than expected for a diffusion-limited process, suggesting that agonist binding involves an energy-requiring event. This hypothesis predicts that competitive antagonist binding should require less activation energy than agonist binding. To test this idea, we developed a novel deconvolution-based method to compare binding and unbinding kinetics of GABAA receptor agonists and antagonists in outside-out patches from rat hippocampal neurons. Agonist and antagonist unbinding rates were steeply correlated with affinity. Unlike the agonists, three of the four antagonists tested had binding rates that were fast, independent of affinity, and could be accounted for by diffusion- and dehydration-limited processes. In contrast, agonist binding involved additional energy-requiring steps, consistent with the idea that channel gating is initiated by agonist-triggered movements within the ligand binding site. Antagonist binding does not appear to produce such movements, and may in fact prevent them.","lang":"eng"}],"pmid":1,"oa_version":"Published Version","date_updated":"2023-05-15T13:50:21Z","extern":"1","type":"journal_article","article_type":"original","status":"public","_id":"3493","page":"2660 - 2670","date_created":"2018-12-11T12:03:37Z","doi":"10.1016/S0006-3495(01)75909-7 ","date_published":"2001-11-01T00:00:00Z","year":"2001","publication":"Biophysical Journal","day":"01","oa":1,"quality_controlled":"1","publisher":"Biophysical Society","external_id":{"pmid":["11606279"]},"article_processing_charge":"No","publist_id":"2894","author":[{"first_name":"M.V","last_name":"Jones","full_name":"Jones, M.V"},{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Y.","last_name":"Sahara","full_name":"Sahara, Y."},{"first_name":"G.","last_name":"Westbrook","full_name":"Westbrook, G."}],"title":"Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists","citation":{"ista":"Jones M., Jonas PM, Sahara Y, Westbrook G. 2001. Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. 81(5), 2660–2670.","chicago":"Jones, M.V, Peter M Jonas, Y. Sahara, and G. Westbrook. “Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists.” Biophysical Journal. Biophysical Society, 2001. https://doi.org/10.1016/S0006-3495(01)75909-7 .","ieee":"M. . Jones, P. M. Jonas, Y. Sahara, and G. Westbrook, “Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists,” Biophysical Journal, vol. 81, no. 5. Biophysical Society, pp. 2660–2670, 2001.","short":"M.. Jones, P.M. Jonas, Y. Sahara, G. Westbrook, Biophysical Journal 81 (2001) 2660–2670.","ama":"Jones M., Jonas PM, Sahara Y, Westbrook G. Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. 2001;81(5):2660-2670. doi:10.1016/S0006-3495(01)75909-7 ","apa":"Jones, M. ., Jonas, P. M., Sahara, Y., & Westbrook, G. (2001). Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. Biophysical Society. https://doi.org/10.1016/S0006-3495(01)75909-7 ","mla":"Jones, M. .., et al. “Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists.” Biophysical Journal, vol. 81, no. 5, Biophysical Society, 2001, pp. 2660–70, doi:10.1016/S0006-3495(01)75909-7 ."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"article_processing_charge":"No","external_id":{"pmid":["11694393"]},"publist_id":"3717","author":[{"first_name":"Libuše","last_name":"Trnková","full_name":"Trnková, Libuše"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596"},{"first_name":"Oldřich","last_name":"Dračka","full_name":"Dračka, Oldřich"}],"title":"Elimination voltammetry of adenine and cytosine mixtures","citation":{"chicago":"Trnková, Libuše, Jiří Friml, and Oldřich Dračka. “Elimination Voltammetry of Adenine and Cytosine Mixtures.” Bioelectrochemistry. Elsevier, 2001. https://doi.org/10.1016/S1567-5394(01)00119-0.","ista":"Trnková L, Friml J, Dračka O. 2001. Elimination voltammetry of adenine and cytosine mixtures. Bioelectrochemistry. 54(2), 131–136.","mla":"Trnková, Libuše, et al. “Elimination Voltammetry of Adenine and Cytosine Mixtures.” Bioelectrochemistry, vol. 54, no. 2, Elsevier, 2001, pp. 131–36, doi:10.1016/S1567-5394(01)00119-0.","ieee":"L. Trnková, J. Friml, and O. Dračka, “Elimination voltammetry of adenine and cytosine mixtures,” Bioelectrochemistry, vol. 54, no. 2. Elsevier, pp. 131–136, 2001.","short":"L. Trnková, J. Friml, O. Dračka, Bioelectrochemistry 54 (2001) 131–136.","apa":"Trnková, L., Friml, J., & Dračka, O. (2001). Elimination voltammetry of adenine and cytosine mixtures. Bioelectrochemistry. Elsevier. https://doi.org/10.1016/S1567-5394(01)00119-0","ama":"Trnková L, Friml J, Dračka O. Elimination voltammetry of adenine and cytosine mixtures. Bioelectrochemistry. 2001;54(2):131-136. doi:10.1016/S1567-5394(01)00119-0"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"131 - 136","date_created":"2018-12-11T12:00:42Z","date_published":"2001-11-01T00:00:00Z","doi":"10.1016/S1567-5394(01)00119-0","year":"2001","publication":"Bioelectrochemistry","day":"01","quality_controlled":"1","publisher":"Elsevier","date_updated":"2023-05-15T14:48:44Z","extern":"1","article_type":"original","type":"journal_article","status":"public","_id":"2985","volume":54,"issue":"2","publication_status":"published","publication_identifier":{"isbn":["1567-5394"]},"language":[{"iso":"eng"}],"intvolume":" 54","month":"11","abstract":[{"lang":"eng","text":"The elimination voltammetry with linear scan (EVLS) was used to study adenine and cytosine reduction signals at the mercury electrode. In comparison with the linear scan voltammetry (which provides only one unresolved peak), two elimination functions provide good resolution of individual peaks and significant increase of sensitivity. The first elimination function eliminates the kinetic current (Ik) and conserves the diffusion current (Id). The second elimination function eliminates kinetic and charging currents (Ik and Ic) simultaneously and conserves the diffusion current (Id). Both functions give two well-resolved peaks of adenine and cytosine in a wide concentration range, while the linear sweep voltammetry gives badly resolved peaks due to hydrogen evolution. The best resolution of peaks is observed in acetate buffer at pH 3.8 and the detection limit for both substances is 500 nM. The concentration dependence of EVLS peak heights for one substance at the constant concentration of the other substance is linear. The peak potentials differ in these elimination functions. The difference in EVLS peak potentials gives the possibility to evaluate αna. Elimination voltammetry with linear scan contributes to the resolution of cathodic signals of purine and pyrimidine bases at very negative potentials near supporting electrolyte discharge. Copyright © 2001 Elsevier Science B.V."}],"pmid":1,"oa_version":"None"},{"title":"Computing visual correspondence with occlusions using graph cuts","author":[{"full_name":"Kolmogorov, Vladimir","last_name":"Kolmogorov","first_name":"Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zabih","full_name":"Zabih, Ramin","first_name":"Ramin"}],"publist_id":"3514","article_processing_charge":"No","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-05-15T14:45:50Z","citation":{"mla":"Kolmogorov, Vladimir, and Ramin Zabih. “Computing Visual Correspondence with Occlusions Using Graph Cuts.” Proceedings of the 8th IEEE International Conference on Computer Vision, vol. 2, IEEE, 2001, pp. 508–15, doi:10.1109/ICCV.2001.937668.","ieee":"V. Kolmogorov and R. Zabih, “Computing visual correspondence with occlusions using graph cuts,” in Proceedings of the 8th IEEE International Conference on Computer Vision, Vancouver, Canada, 2001, vol. 2, pp. 508–515.","short":"V. Kolmogorov, R. Zabih, in:, Proceedings of the 8th IEEE International Conference on Computer Vision, IEEE, 2001, pp. 508–515.","ama":"Kolmogorov V, Zabih R. Computing visual correspondence with occlusions using graph cuts. In: Proceedings of the 8th IEEE International Conference on Computer Vision. Vol 2. IEEE; 2001:508-515. doi:10.1109/ICCV.2001.937668","apa":"Kolmogorov, V., & Zabih, R. (2001). Computing visual correspondence with occlusions using graph cuts. In Proceedings of the 8th IEEE International Conference on Computer Vision (Vol. 2, pp. 508–515). Vancouver, Canada: IEEE. https://doi.org/10.1109/ICCV.2001.937668","chicago":"Kolmogorov, Vladimir, and Ramin Zabih. “Computing Visual Correspondence with Occlusions Using Graph Cuts.” In Proceedings of the 8th IEEE International Conference on Computer Vision, 2:508–15. IEEE, 2001. https://doi.org/10.1109/ICCV.2001.937668.","ista":"Kolmogorov V, Zabih R. 2001. Computing visual correspondence with occlusions using graph cuts. Proceedings of the 8th IEEE International Conference on Computer Vision. ICCV: International Conference on Computer Vision vol. 2, 508–515."},"status":"public","type":"conference","conference":{"name":"ICCV: International Conference on Computer Vision","start_date":"2001-07-07","location":"Vancouver, Canada","end_date":"2001-07-14"},"_id":"3169","date_published":"2001-08-01T00:00:00Z","doi":"10.1109/ICCV.2001.937668","volume":2,"date_created":"2018-12-11T12:01:47Z","page":"508 - 515","day":"01","language":[{"iso":"eng"}],"publication":"Proceedings of the 8th IEEE International Conference on Computer Vision","publication_identifier":{"isbn":["0769511430"]},"publication_status":"published","year":"2001","month":"08","intvolume":" 2","publisher":"IEEE","quality_controlled":"1","oa_version":"None","abstract":[{"lang":"eng","text":"Several new algorithms for visual correspondence based on graph cuts [7, 14, 17] have recently been developed. While these methods give very strong results in practice, they do not handle occlusions properly. Specifically, they treat the two input images asymmetrically, and they do not ensure that a pixel corresponds to at most one pixel in the other image. In this paper, we present a new method which properly addresses occlusions, while preserving the advantages of graph cut algorithms. We give experimental results for stereo as well as motion, which demonstrate that our method performs well both at detecting occlusions and computing disparities."}]},{"extern":"1","date_updated":"2023-05-15T13:58:49Z","_id":"3439","status":"public","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["1471-8278"]},"issue":"4","volume":1,"oa_version":"None","abstract":[{"lang":"eng","text":"High molecular weight DNA was extracted from the primary Neotropical malaria vector, Anopheles darlingi from Capanema, Pará, Brazil, to create a small insert genomic library, and then a phagemid library. Enriched sublibraries were constructed from the phagemid library using a microsatellite oligo primed second strand synthesis protocol. The resulting 242 760 individual clones were screened. The mean clone size of the positive clones was 302 bp. Flanking primers were designed for each suitable microsatellite sequence. Eight polymorphic loci were optimized and characterized. The allele size ranges are based on 253 samples of A. darlingi from eastern Amazonian and central Brazil."}],"intvolume":" 1","month":"12","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Conn, Jan, et al. “Isolation of Polymorphic Microsatellite Markers from the Malaria Vector Anopheles Darlingi.” Molecular Ecology Notes, vol. 1, no. 4, Wiley-Blackwell, 2001, pp. 223–25, doi: 10.1046/j.1471-8278.2001.00078.x.","short":"J. Conn, J.P. Bollback, D. Onyabe, T. Robinson, R. Wilkerson, M. Povoa, Molecular Ecology Notes 1 (2001) 223–225.","ieee":"J. Conn, J. P. Bollback, D. Onyabe, T. Robinson, R. Wilkerson, and M. Povoa, “Isolation of polymorphic microsatellite markers from the malaria vector Anopheles darlingi,” Molecular Ecology Notes, vol. 1, no. 4. Wiley-Blackwell, pp. 223–225, 2001.","apa":"Conn, J., Bollback, J. P., Onyabe, D., Robinson, T., Wilkerson, R., & Povoa, M. (2001). Isolation of polymorphic microsatellite markers from the malaria vector Anopheles darlingi. Molecular Ecology Notes. Wiley-Blackwell. https://doi.org/ 10.1046/j.1471-8278.2001.00078.x","ama":"Conn J, Bollback JP, Onyabe D, Robinson T, Wilkerson R, Povoa M. Isolation of polymorphic microsatellite markers from the malaria vector Anopheles darlingi. Molecular Ecology Notes. 2001;1(4):223-225. doi: 10.1046/j.1471-8278.2001.00078.x","chicago":"Conn, Jan, Jonathan P Bollback, David Onyabe, Tessa Robinson, Richard Wilkerson, and Marinete Povoa. “Isolation of Polymorphic Microsatellite Markers from the Malaria Vector Anopheles Darlingi.” Molecular Ecology Notes. Wiley-Blackwell, 2001. https://doi.org/ 10.1046/j.1471-8278.2001.00078.x.","ista":"Conn J, Bollback JP, Onyabe D, Robinson T, Wilkerson R, Povoa M. 2001. Isolation of polymorphic microsatellite markers from the malaria vector Anopheles darlingi. Molecular Ecology Notes. 1(4), 223–225."},"title":"Isolation of polymorphic microsatellite markers from the malaria vector Anopheles darlingi","article_processing_charge":"No","publist_id":"2961","author":[{"first_name":"Jan","last_name":"Conn","full_name":"Conn, Jan"},{"full_name":"Bollback, Jonathan P","orcid":"0000-0002-4624-4612","last_name":"Bollback","first_name":"Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Onyabe, David","last_name":"Onyabe","first_name":"David"},{"full_name":"Robinson, Tessa","last_name":"Robinson","first_name":"Tessa"},{"first_name":"Richard","full_name":"Wilkerson, Richard","last_name":"Wilkerson"},{"last_name":"Povoa","full_name":"Povoa, Marinete","first_name":"Marinete"}],"publication":"Molecular Ecology Notes","day":"01","year":"2001","date_created":"2018-12-11T12:03:20Z","doi":" 10.1046/j.1471-8278.2001.00078.x","date_published":"2001-12-01T00:00:00Z","page":"223 - 225","acknowledgement":"For support in Brazil we thank D. Galiza, R.N.L. Lacerda,E.P. Santa Rosa, M.N.O. Segura, and R.T.L. de Souza. We also thankM.J. Braun for allowing work on the library construction at theLaboratory of Molecular Systematics, Washington. Supported byNIH AI 40116 to JEC and Instituto Evandro Chagas, Belém, Brazil.","publisher":"Wiley-Blackwell","quality_controlled":"1"},{"year":"2001","publication":"Systematic Biology","day":"01","page":"351 - 366","date_created":"2018-12-11T12:03:20Z","date_published":"2001-05-01T00:00:00Z","doi":"10.1080/10635150119871","quality_controlled":"1","publisher":"Oxford University Press","citation":{"apa":"Huelsenbeck, J., & Bollback, J. P. (2001). Empirical and hierarchical Bayesian estimation of ancestral states. Systematic Biology. Oxford University Press. https://doi.org/10.1080/10635150119871","ama":"Huelsenbeck J, Bollback JP. Empirical and hierarchical Bayesian estimation of ancestral states. Systematic Biology. 2001;50(3):351-366. doi:10.1080/10635150119871","ieee":"J. Huelsenbeck and J. P. Bollback, “Empirical and hierarchical Bayesian estimation of ancestral states,” Systematic Biology, vol. 50, no. 3. Oxford University Press, pp. 351–366, 2001.","short":"J. Huelsenbeck, J.P. Bollback, Systematic Biology 50 (2001) 351–366.","mla":"Huelsenbeck, John, and Jonathan P. Bollback. “Empirical and Hierarchical Bayesian Estimation of Ancestral States.” Systematic Biology, vol. 50, no. 3, Oxford University Press, 2001, pp. 351–66, doi:10.1080/10635150119871.","ista":"Huelsenbeck J, Bollback JP. 2001. Empirical and hierarchical Bayesian estimation of ancestral states. Systematic Biology. 50(3), 351–366.","chicago":"Huelsenbeck, John, and Jonathan P Bollback. “Empirical and Hierarchical Bayesian Estimation of Ancestral States.” Systematic Biology. Oxford University Press, 2001. https://doi.org/10.1080/10635150119871."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["12116580"]},"publist_id":"2960","author":[{"last_name":"Huelsenbeck","full_name":"Huelsenbeck, John","first_name":"John"},{"last_name":"Bollback","orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","first_name":"Jonathan P"}],"title":"Empirical and hierarchical Bayesian estimation of ancestral states","publication_status":"published","publication_identifier":{"issn":["0039-7989"]},"language":[{"iso":"eng"}],"volume":50,"issue":"3","abstract":[{"lang":"eng","text":"Several methods have been proposed to infer the states at the ancestral nodes on a phylogeny. These methods assume a specific tree and set of branch lengths when estimating the ancestral character state. Inferences of the ancestral states, then, are conditioned on the tree and branch lengths being true. We develop a hierarchical Bayes method for inferring the ancestral states on a tree. The method integrates over uncertainty in the tree, branch lengths, and substitution model parameters by using Markov chain Monte Carlo. We compare the hierarchical Bayes inferences of ancestral states with inferences of ancestral states made under the assumption that a specific tree is correct. We find that the methods are correlated, but that accommodating uncertainty in parameters of the phylogenetic model can make inferences of ancestral states even more uncertain than they would be in an empirical Bayes analysis.\r\n"}],"oa_version":"None","pmid":1,"intvolume":" 50","month":"05","date_updated":"2023-05-15T13:54:01Z","extern":"1","_id":"3440","article_type":"original","type":"journal_article","status":"public"},{"_id":"3438","status":"public","type":"journal_article","extern":"1","date_updated":"2023-05-15T14:10:13Z","pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"As a discipline, phylogenetics is becoming transformed by a flood of molecular data. These data allow broad questions to be asked about the history of life, but also present difficult statistical and computational problems. Bayesian inference of phylogeny brings a new perspective to a number of outstanding issues in evolutionary biology, including the analysis of large phylogenetic trees and complex evolutionary models and the detection of the footprint of natural selection in DNA sequences."}],"month":"12","intvolume":" 294","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0036-8075"]},"publication_status":"published","issue":"5550","volume":294,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Huelsenbeck, John, et al. “Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” Science, vol. 294, no. 5550, American Association for the Advancement of Science, 2001, pp. 2310–14, doi:10.1126/science.1065889.","short":"J. Huelsenbeck, F. Ronquist, R. Nielsen, J.P. Bollback, Science 294 (2001) 2310–2314.","ieee":"J. Huelsenbeck, F. Ronquist, R. Nielsen, and J. P. Bollback, “Bayesian inference of phylogeny and its impact on evolutionary biology,” Science, vol. 294, no. 5550. American Association for the Advancement of Science, pp. 2310–2314, 2001.","apa":"Huelsenbeck, J., Ronquist, F., Nielsen, R., & Bollback, J. P. (2001). Bayesian inference of phylogeny and its impact on evolutionary biology. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1065889","ama":"Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. Bayesian inference of phylogeny and its impact on evolutionary biology. Science. 2001;294(5550):2310-2314. doi:10.1126/science.1065889","chicago":"Huelsenbeck, John, Fredrik Ronquist, Rasmus Nielsen, and Jonathan P Bollback. “Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” Science. American Association for the Advancement of Science, 2001. https://doi.org/10.1126/science.1065889.","ista":"Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. 2001. Bayesian inference of phylogeny and its impact on evolutionary biology. Science. 294(5550), 2310–2314."},"title":"Bayesian inference of phylogeny and its impact on evolutionary biology","publist_id":"2962","author":[{"first_name":"John","full_name":"Huelsenbeck, John","last_name":"Huelsenbeck"},{"first_name":"Fredrik","full_name":"Ronquist, Fredrik","last_name":"Ronquist"},{"last_name":"Nielsen","full_name":"Nielsen, Rasmus","first_name":"Rasmus"},{"first_name":"Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","last_name":"Bollback","full_name":"Bollback, Jonathan P","orcid":"0000-0002-4624-4612"}],"article_processing_charge":"No","external_id":{"pmid":["11743192 "]},"quality_controlled":"1","publisher":"American Association for the Advancement of Science","day":"14","publication":"Science","year":"2001","date_published":"2001-12-14T00:00:00Z","doi":"10.1126/science.1065889","date_created":"2018-12-11T12:03:20Z","page":"2310 - 2314"},{"date_updated":"2023-05-15T14:43:39Z","citation":{"mla":"Huelsenbeck, John, and Jonathan P. Bollback. “Application of the Likelihood Function in Phylogenetic Analysis.” Handbook of Statistical Genetics, edited by David Balding et al., Wiley-Blackwell, 2001, pp. 415–39, doi:10.1002/9780470061619.ch15.","short":"J. Huelsenbeck, J.P. Bollback, in:, D. Balding, M. Bishop, C. Cannings (Eds.), Handbook of Statistical Genetics, Wiley-Blackwell, 2001, pp. 415–439.","ieee":"J. Huelsenbeck and J. P. Bollback, “Application of the likelihood function in phylogenetic analysis,” in Handbook of Statistical Genetics, D. Balding, M. Bishop, and C. Cannings, Eds. Wiley-Blackwell, 2001, pp. 415–439.","apa":"Huelsenbeck, J., & Bollback, J. P. (2001). Application of the likelihood function in phylogenetic analysis. In D. Balding, M. Bishop, & C. Cannings (Eds.), Handbook of Statistical Genetics (pp. 415–439). Wiley-Blackwell. https://doi.org/10.1002/9780470061619.ch15","ama":"Huelsenbeck J, Bollback JP. Application of the likelihood function in phylogenetic analysis. In: Balding D, Bishop M, Cannings C, eds. Handbook of Statistical Genetics. Wiley-Blackwell; 2001:415-439. doi:10.1002/9780470061619.ch15","chicago":"Huelsenbeck, John, and Jonathan P Bollback. “Application of the Likelihood Function in Phylogenetic Analysis.” In Handbook of Statistical Genetics, edited by David Balding, Martin Bishop, and Chriss Cannings, 415–39. Wiley-Blackwell, 2001. https://doi.org/10.1002/9780470061619.ch15.","ista":"Huelsenbeck J, Bollback JP. 2001.Application of the likelihood function in phylogenetic analysis. In: Handbook of Statistical Genetics. , 415–439."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","article_processing_charge":"No","publist_id":"2966","author":[{"first_name":"John","last_name":"Huelsenbeck","full_name":"Huelsenbeck, John"},{"id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","first_name":"Jonathan P","last_name":"Bollback","orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P"}],"editor":[{"last_name":"Balding","full_name":"Balding, David","first_name":"David"},{"full_name":"Bishop, Martin","last_name":"Bishop","first_name":"Martin"},{"first_name":"Chriss","full_name":"Cannings, Chriss","last_name":"Cannings"}],"title":"Application of the likelihood function in phylogenetic analysis","_id":"3434","type":"book_chapter","status":"public","year":"2001","publication_status":"published","publication_identifier":{"isbn":["9781119429142 "]},"language":[{"iso":"eng"}],"publication":"Handbook of Statistical Genetics","day":"01","page":"415 - 439","date_created":"2018-12-11T12:03:19Z","date_published":"2001-01-01T00:00:00Z","doi":"10.1002/9780470061619.ch15","abstract":[{"text":"This chapter contains sections titled:\r\n\r\nIntroduction\r\n\r\n- History\r\n\r\n- Developing an Intuition of Likelihood\r\n\r\n- Method of Maximum Likelihood\r\n\r\n- Bayesian Inference\r\n\r\n- Markov Chain Monte Carlo\r\n\r\n- Assessing Uncertainty of Phylogenies\r\n\r\n- Hypothesis Testing and Model Choice\r\n\r\n- Comparative Analysis\r\n\r\n- Conclusions\r\n\r\n- References","lang":"eng"}],"oa_version":"None","quality_controlled":"1","publisher":"Wiley-Blackwell","month":"01"},{"quality_controlled":"1","publisher":"Cold Spring Harbor Laboratory Press","oa":1,"acknowledgement":"We thank Kim Hanson and Melissa McCarthy for technical support, and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning this manuscript. This work was supported by grants from the Department of Energy (DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","doi":"10.1101/gad.905201","date_published":"2001-08-01T00:00:00Z","date_created":"2018-12-11T12:00:41Z","page":"1985 - 1997","day":"01","publication":"Genes and Development","year":"2001","title":"BIG: A calossin-like protein required for polar auxin transport in Arabidopsis","author":[{"last_name":"Gil","full_name":"Gil, Pedro","first_name":"Pedro"},{"full_name":"Dewey, Elizabeth","last_name":"Dewey","first_name":"Elizabeth"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Yunde","last_name":"Zhao","full_name":"Zhao, Yunde"},{"full_name":"Snowden, Kimberley","last_name":"Snowden","first_name":"Kimberley"},{"first_name":"Jo","full_name":"Putterill, Jo","last_name":"Putterill"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"},{"last_name":"Estelle","full_name":"Estelle, Mark","first_name":"Mark"},{"first_name":"Joanne","last_name":"Chory","full_name":"Chory, Joanne"}],"publist_id":"3720","article_processing_charge":"No","external_id":{"pmid":["11485992"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development, vol. 15, no. 15, Cold Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:10.1101/gad.905201.","apa":"Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory, J. (2001). BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.905201","ama":"Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. 2001;15(15):1985-1997. doi:10.1101/gad.905201","short":"P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme, M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.","ieee":"P. Gil et al., “BIG: A calossin-like protein required for polar auxin transport in Arabidopsis,” Genes and Development, vol. 15, no. 15. Cold Spring Harbor Laboratory Press, pp. 1985–1997, 2001.","chicago":"Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden, Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.905201.","ista":"Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. 15(15), 1985–1997."},"month":"08","intvolume":" 15","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/","open_access":"1"}],"oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng","text":"Polar auxin transport is crucial for the regulation of auxin action and required for some light-regulated responses during plant development. We have found that two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated genes, and tir3, known for its reduced auxin transport - have similar defects and define mutations in a single gene that we have renamed BIG. BIG is very similar to the Drosophila gene Calossin/Pushover, a member of a gene family also present in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling experiments indicate that altered expression of multiple light-regulated genes in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression of an auxin biosynthetic gene, suggesting that normal auxin distribution is required to maintain low-level expression of these genes in the dark. Double mutants of tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent growth of the inflorescence. Chemical inhibitors of auxin transport change the intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants, supporting the idea that BIG is required for normal auxin efflux."}],"volume":15,"issue":"15","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0890-9369"]},"publication_status":"published","status":"public","type":"journal_article","article_type":"original","_id":"2982","extern":"1","date_updated":"2023-05-16T11:59:47Z"},{"citation":{"ista":"Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. 15(20), 2648–2653.","chicago":"Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg, Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.210501.","short":"R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett, Genes and Development 15 (2001) 2648–2653.","ieee":"R. Swarup et al., “Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex,” Genes and Development, vol. 15, no. 20. Cold Spring Harbor Laboratory Press, pp. 2648–2653, 2001.","ama":"Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. 2001;15(20):2648-2653. doi:10.1101/gad.210501","apa":"Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., & Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.210501","mla":"Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” Genes and Development, vol. 15, no. 20, Cold Spring Harbor Laboratory Press, 2001, pp. 2648–53, doi:10.1101/gad.210501."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"3718","author":[{"last_name":"Swarup","full_name":"Swarup, Ranjan","first_name":"Ranjan"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"full_name":"Marchant, Alan","last_name":"Marchant","first_name":"Alan"},{"full_name":"Ljung, Karin","last_name":"Ljung","first_name":"Karin"},{"first_name":"Göran","last_name":"Sandberg","full_name":"Sandberg, Göran"},{"full_name":"Palme, Klaus","last_name":"Palme","first_name":"Klaus"},{"first_name":"Malcolm","last_name":"Bennett","full_name":"Bennett, Malcolm"}],"article_processing_charge":"No","external_id":{"pmid":["11641271"]},"title":"Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex","acknowledgement":"We thank Ben Scheres and Marcus Grebe for critically reading the manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis Baker for valuable discussion. This work was funded by the BBSRC and European Commission grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","publisher":"Cold Spring Harbor Laboratory Press","quality_controlled":"1","oa":1,"year":"2001","day":"15","publication":"Genes and Development","page":"2648 - 2653","doi":"10.1101/gad.210501","date_published":"2001-10-15T00:00:00Z","date_created":"2018-12-11T12:00:41Z","_id":"2984","type":"journal_article","article_type":"original","status":"public","date_updated":"2023-05-16T11:37:53Z","extern":"1","abstract":[{"lang":"eng","text":"Auxins represent an important class of plant hormone that regulate plant development. Plants use specialized carrier proteins to transport the auxin indole-3-acetic acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport has been assumed to represent the sole mode of long distance IAA movement. Localization of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of root protophloem cells, is proposed to promote the acropetal, post-phloem movement of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1 localization to columella and lateral root cap tissues of the Arabidopsis root apex reveals that the auxin permease regulates a second IAA transport pathway. Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary for root gravitropism by facilitating basipetal auxin transport to distal elongation zone tissues."}],"pmid":1,"oa_version":"Published Version","scopus_import":"1","main_file_link":[{"url":"ncbi.nlm.nih.gov/pmc/articles/PMC312818/","open_access":"1"}],"month":"10","intvolume":" 15","publication_identifier":{"issn":["Genes and Development"]},"publication_status":"published","language":[{"iso":"eng"}],"volume":15,"issue":"20"},{"article_type":"original","type":"journal_article","status":"public","_id":"2981","date_updated":"2023-05-16T12:07:45Z","extern":"1","scopus_import":"1","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/","open_access":"1"}],"month":"06","intvolume":" 20","abstract":[{"lang":"eng","text":"Plants contain a novel unique subfamily of Rho GTPases, vital components of cellular signalling networks. Here we report a general role for some members of this family in polarized plant growth processes. We show that Arabidopsis AtRop4 and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates. We localized AtRop proteins in root meristem cells to the cross-wall and cell plate membranes. Polar localization of AtRops in trichoblasts specifies the growth sites for emerging root hairs. These sites were visible before budding and elongation of the Arabidopsis root hair when AtRops accumulated at their tips. Expression of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic Arabidopsis plants abolished polarized growth and delocalized the tip-focused Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse growth."}],"pmid":1,"oa_version":"Published Version","volume":20,"issue":"11","publication_identifier":{"issn":["0261-4189"]},"publication_status":"published","language":[{"iso":"eng"}],"publist_id":"3721","author":[{"first_name":"Arthur","full_name":"Molendijk, Arthur","last_name":"Molendijk"},{"first_name":"Friedrich","last_name":"Bischoff","full_name":"Bischoff, Friedrich"},{"last_name":"Rajendrakumar","full_name":"Rajendrakumar, Chadalavada","first_name":"Chadalavada"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí"},{"first_name":"Markus","full_name":"Braun, Markus","last_name":"Braun"},{"last_name":"Gilroy","full_name":"Gilroy, Simon","first_name":"Simon"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"}],"article_processing_charge":"No","external_id":{"pmid":["11387211"]},"title":"Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth","citation":{"mla":"Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO Journal, vol. 20, no. 11, Wiley-Blackwell, 2001, pp. 2779–88, doi:10.1093/emboj/20.11.2779.","ieee":"A. Molendijk et al., “Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth,” EMBO Journal, vol. 20, no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.","short":"A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy, K. Palme, EMBO Journal 20 (2001) 2779–2788.","ama":"Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. 2001;20(11):2779-2788. doi:10.1093/emboj/20.11.2779","apa":"Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy, S., & Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1093/emboj/20.11.2779","chicago":"Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO Journal. Wiley-Blackwell, 2001. https://doi.org/10.1093/emboj/20.11.2779.","ista":"Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. 20(11), 2779–2788."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Wiley-Blackwell","quality_controlled":"1","oa":1,"acknowledgement":"We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98 0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.","page":"2779 - 2788","doi":"10.1093/emboj/20.11.2779","date_published":"2001-06-01T00:00:00Z","date_created":"2018-12-11T12:00:40Z","year":"2001","day":"01","publication":"EMBO Journal"},{"date_published":"2001-09-27T00:00:00Z","doi":"10.1038/35096571","date_created":"2018-12-11T12:00:41Z","page":"425 - 428","day":"27","publication":"Nature","year":"2001","publisher":"Nature Publishing Group","quality_controlled":"1","title":"Auxin transport inhibitors block PIN1 cycling and vesicle trafficking","author":[{"first_name":"Niko","full_name":"Geldner, Niko","last_name":"Geldner"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"first_name":"York","full_name":"Stierhof, York","last_name":"Stierhof"},{"first_name":"Gerd","last_name":"Jürgens","full_name":"Jürgens, Gerd"},{"first_name":"Klaus","last_name":"Palme","full_name":"Palme, Klaus"}],"publist_id":"3719","external_id":{"pmid":["11574889"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Geldner, Niko, Jiří Friml, York Stierhof, Gerd Jürgens, and Klaus Palme. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” Nature. Nature Publishing Group, 2001. https://doi.org/10.1038/35096571.","ista":"Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. 2001. Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854), 425–428.","mla":"Geldner, Niko, et al. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” Nature, vol. 413, no. 6854, Nature Publishing Group, 2001, pp. 425–28, doi:10.1038/35096571.","short":"N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, K. Palme, Nature 413 (2001) 425–428.","ieee":"N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, and K. Palme, “Auxin transport inhibitors block PIN1 cycling and vesicle trafficking,” Nature, vol. 413, no. 6854. Nature Publishing Group, pp. 425–428, 2001.","ama":"Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature. 2001;413(6854):425-428. doi:10.1038/35096571","apa":"Geldner, N., Friml, J., Stierhof, Y., Jürgens, G., & Palme, K. (2001). Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature. Nature Publishing Group. https://doi.org/10.1038/35096571"},"issue":"6854","volume":413,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0028-0836"]},"publication_status":"published","month":"09","intvolume":" 413","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"Polar transport of the phytohormone auxin mediates various processes in plant growth and development, such as apical dominance, tropisms, vascular patterning and axis formation. This view is based largely on the effects of polar auxin transport inhibitors. These compounds disrupt auxin efflux from the cell but their mode of action is unknown. It is thought that polar auxin flux is caused by the asymmetric distribution of efflux carriers acting at the plasma membrane. The polar localization of efflux carrier candidate PIN1 supports this model. Here we show that the seemingly static localization of PIN1 results from rapid actin-dependent cycling between the plasma membrane and endosomal compartments. Auxin transport inhibitors block PIN1 cycling and inhibit trafficking of membrane proteins that are unrelated to auxin transport. Our data suggest that PIN1 cycling is of central importance for auxin transport and that auxin transport inhibitors affect efflux by generally interfering with membrane-trafficking processes. In support of our conclusion, the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of auxin transport inhibitors."}],"extern":"1","date_updated":"2023-05-16T11:51:44Z","status":"public","article_type":"letter_note","type":"journal_article","_id":"2983"},{"citation":{"chicago":"Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical Physics. International Press, 2001. https://doi.org/10.48550/arXiv.math-ph/0111042.","ista":"Erdös L, Yau H. 2001. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. 5(6), 1169–1205.","mla":"Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical Physics, vol. 5, no. 6, International Press, 2001, pp. 1169–205, doi:10.48550/arXiv.math-ph/0111042.","ieee":"L. Erdös and H. Yau, “Derivation of the nonlinear Schrödinger equation from a many body Coulomb system,” Advances in Theoretical and Mathematical Physics, vol. 5, no. 6. International Press, pp. 1169–1205, 2001.","short":"L. Erdös, H. Yau, Advances in Theoretical and Mathematical Physics 5 (2001) 1169–1205.","ama":"Erdös L, Yau H. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. 2001;5(6):1169-1205. doi:10.48550/arXiv.math-ph/0111042","apa":"Erdös, L., & Yau, H. (2001). Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. International Press. https://doi.org/10.48550/arXiv.math-ph/0111042"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"arxiv":["math-ph/0111042"]},"author":[{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"full_name":"Yau, Horng","last_name":"Yau","first_name":"Horng"}],"publist_id":"4156","title":"Derivation of the nonlinear Schrödinger equation from a many body Coulomb system","oa":1,"quality_controlled":"1","publisher":"International Press","year":"2001","publication":"Advances in Theoretical and Mathematical Physics","day":"01","page":"1169 - 1205","date_created":"2018-12-11T11:59:20Z","doi":"10.48550/arXiv.math-ph/0111042","date_published":"2001-11-01T00:00:00Z","_id":"2736","type":"journal_article","article_type":"original","status":"public","date_updated":"2023-05-16T12:12:41Z","extern":"1","abstract":[{"text":"We consider the time evolution of N bosonic particles interacting via a mean field Coulomb potential. Suppose the initial state is a product wavefunction. We show that at any finite time the correlation functions factorize in the limit N → ∞. Furthermore, the limiting one particle density matrix satisfies the nonlinear Hartree equation. The key ingredients are the uniqueness of the BBGKY hierarchy for the correlation functions and a new apriori estimate for the many-body Schrödinger equations.","lang":"eng"}],"oa_version":"Published Version","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0111042","open_access":"1"}],"scopus_import":"1","intvolume":" 5","month":"11","publication_status":"published","publication_identifier":{"issn":["1095-0761"]},"language":[{"iso":"eng"}],"issue":"6","volume":5},{"abstract":[{"lang":"eng","text":"We establish the exact low-energy asymptotics of the integrated density of states (Lifschitz tail) in a homogeneous magnetic field and Poissonian impurities with a repulsive single-site potential of Gaussian decay. It has been known that the Gaussian potential tail discriminates between the so-called “classical” and “quantum” regimes, and precise asymptotics are known in these cases. For the borderline case, the coexistence of the classical and quantum regimes was conjectured. Here we settle this last remaining open case to complete the full picture of the magnetic Lifschitz tails."}],"oa_version":"Published Version","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/math-ph/0003023","open_access":"1"}],"month":"10","intvolume":" 121","publication_identifier":{"issn":["0044-3719"]},"publication_status":"published","language":[{"iso":"eng"}],"volume":121,"issue":"2","_id":"2735","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-16T12:20:42Z","extern":"1","publisher":"Springer","quality_controlled":"1","oa":1,"year":"2001","day":"01","publication":"Probability Theory and Related Fields","page":"219 - 236","date_published":"2001-10-01T00:00:00Z","doi":"10.1007/PL00008803","date_created":"2018-12-11T11:59:19Z","citation":{"chicago":"Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” Probability Theory and Related Fields. Springer, 2001. https://doi.org/10.1007/PL00008803.","ista":"Erdös L. 2001. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. 121(2), 219–236.","mla":"Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” Probability Theory and Related Fields, vol. 121, no. 2, Springer, 2001, pp. 219–36, doi:10.1007/PL00008803.","ama":"Erdös L. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. 2001;121(2):219-236. doi:10.1007/PL00008803","apa":"Erdös, L. (2001). Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. Springer. https://doi.org/10.1007/PL00008803","short":"L. Erdös, Probability Theory and Related Fields 121 (2001) 219–236.","ieee":"L. Erdös, “Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case,” Probability Theory and Related Fields, vol. 121, no. 2. Springer, pp. 219–236, 2001."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"}],"publist_id":"4157","external_id":{"arxiv":["math-ph/0003023"]},"article_processing_charge":"No","title":"Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case"},{"abstract":[{"lang":"eng","text":"In this paper we describe an intrinsically geometric way of producing magnetic fields on S3 and R3 for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau [1]."}],"oa_version":"Published Version","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/math-ph/0001036","open_access":"1"}],"month":"10","intvolume":" 13","publication_identifier":{"issn":["0129-055X"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"10","volume":13,"_id":"2734","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-16T12:24:25Z","extern":"1","quality_controlled":"1","publisher":"World Scientific Publishing","oa":1,"year":"2001","day":"01","publication":"Reviews in Mathematical Physics","page":"1247 - 1280","doi":"10.1142/S0129055X01000983","date_published":"2001-10-01T00:00:00Z","date_created":"2018-12-11T11:59:19Z","citation":{"mla":"Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” Reviews in Mathematical Physics, vol. 13, no. 10, World Scientific Publishing, 2001, pp. 1247–80, doi:10.1142/S0129055X01000983.","apa":"Erdös, L., & Solovej, J. (2001). The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. World Scientific Publishing. https://doi.org/10.1142/S0129055X01000983","ama":"Erdös L, Solovej J. The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. 2001;13(10):1247-1280. doi:10.1142/S0129055X01000983","short":"L. Erdös, J. Solovej, Reviews in Mathematical Physics 13 (2001) 1247–1280.","ieee":"L. Erdös and J. Solovej, “The kernel of Dirac operators on S3 and R3,” Reviews in Mathematical Physics, vol. 13, no. 10. World Scientific Publishing, pp. 1247–1280, 2001.","chicago":"Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” Reviews in Mathematical Physics. World Scientific Publishing, 2001. https://doi.org/10.1142/S0129055X01000983.","ista":"Erdös L, Solovej J. 2001. The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. 13(10), 1247–1280."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"first_name":"Jan","full_name":"Solovej, Jan","last_name":"Solovej"}],"publist_id":"4158","article_processing_charge":"No","external_id":{"arxiv":["math-ph/0001036"]},"title":"The kernel of Dirac operators on S3 and R3"},{"acknowledgement":"The work contained in this manuscript was sponsored by the Canadian MRC, Grants # MT-12170 and MoP-38093. The authors would like to thank Sylvain Cote for technical assistance and Sid Parkinson for editorial assistance.","publisher":"Elsevier","quality_controlled":"1","year":"2001","day":"05","publication":"Neuroscience","page":"157 - 166","doi":"10.1016/S0306-4522(01)00158-0","date_published":"2001-12-05T00:00:00Z","date_created":"2018-12-11T11:58:40Z","citation":{"ista":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. Neuroscience. 108(1), 157–166.","chicago":"Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro Da Silva. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory Fibre Plasticity in the Rat Skin.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00158-0.","ieee":"I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin,” Neuroscience, vol. 108, no. 1. Elsevier, pp. 157–166, 2001.","short":"I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Neuroscience 108 (2001) 157–166.","ama":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. Neuroscience. 2001;108(1):157-166. doi:10.1016/S0306-4522(01)00158-0","apa":"Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00158-0","mla":"Ruocco, Isabella, et al. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory Fibre Plasticity in the Rat Skin.” Neuroscience, vol. 108, no. 1, Elsevier, 2001, pp. 157–66, doi:10.1016/S0306-4522(01)00158-0."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","author":[{"full_name":"Ruocco, Isabella","last_name":"Ruocco","first_name":"Isabella"},{"full_name":"Cuello, Augusto","last_name":"Cuello","first_name":"Augusto"},{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alfredo","last_name":"Ribeiro Da Silva","full_name":"Ribeiro Da Silva, Alfredo"}],"publist_id":"4286","article_processing_charge":"No","external_id":{"pmid":["11738139"]},"title":"Sympathectomies lead to transient substance P-immunoreactive sensory fibre plasticity in the rat skin","abstract":[{"lang":"eng","text":"Research using animal models of neuropathic pain has revealed sympathetic sprouting onto dorsal root ganglion cells. More recently, sensory fibre sprouting onto dorsal root ganglion cells has also been observed. Previous work in our laboratory demonstrated persistent sympathetic fibre sprouting in the skin of the rat lower lip following sensory denervation of this region. Therefore, we applied immunocytochemistry to determine the effects of sympathectomies on the terminal fields of sensory fibres. The superior cervical ganglia were removed bilaterally and the effects on the innervation of the skin of the rat lower lip were observed 1, 2, 3, 4, 6 and 8 weeks post-surgery. Substance P and dopamine-β-hydroxylase immunoreactivities were used to identify a subset of sensory and sympathetic fibres, respectively. We also assessed neurokinin-1 receptor immunoreactivity. Quantitative data was obtained with the aid of an image analysis system. In controls, the epidermis and upper dermis were innervated by substance P-immunoreactive fibres only and upper dermal blood vessels possessed the highest density of neurokinin-1 receptor immunoreactivity. Blood vessels in the lower dermis were innervated by both substance P- and dopamine-β-hydroxylase-immunoreactive fibres. Following sympathectomies, substance P-immunoreactive fibres in the epidermis and upper dermis were more intensely labelled only 1 and 2 weeks post-surgery when compared to sham controls. The length of substance P-immunoreactive fibres in this region was also increased only on the second week. Neurokinin-1 receptor immunoreactivity in the upper dermis was slightly decreased 1 and 2 weeks post-surgery. In the lower dermis, substance P-immunoreactive fibres associated with blood vessels were more intensely labelled only 1 and 2 weeks post-surgery, and at all post-surgical time points studied, blood vessels in this region were devoid of dopamine-β-hydroxylase-immunoreactive fibres. The length of substance P-immunoreactive fibres was increased from the first to the third week post-surgery in the lower dermis. These results indicate that sympathectomies lead to transient changes in substance P-immunoreactive fibre innervation and neurokinin-1 receptor expression in rat lower lip skin. The effects are most prominent in the lower dermis probably due to a greater local concentration of nerve growth factor in this region. The plasticity of the interactions between sensory and sympathetic fibres may prove important in the regulation of skin microcirculation and in the generation of painful sensations under normal conditions or following peripheral nerve injuries."}],"oa_version":"None","pmid":1,"scopus_import":"1","month":"12","intvolume":" 108","publication_identifier":{"issn":["0306-4522"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"1","volume":108,"_id":"2611","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-22T12:15:44Z","extern":"1"},{"publication":"Neuroscience Letters","day":"23","year":"2001","date_created":"2018-12-11T11:58:40Z","doi":"10.1016/S0304-3940(01)02321-7","date_published":"2001-11-23T00:00:00Z","page":"93 - 97","acknowledgement":"This work was supported in part by Grants-in-Aid from the National Natural Science Foundation of China (39870262, 39970239), from the Foundation for University Key Teacher of the Ministry of Education of China, and from the Ministry of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).","publisher":"Elsevier","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters. Elsevier, 2001. https://doi.org/10.1016/S0304-3940(01)02321-7.","ista":"Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience Letters. 315(1–2), 93–97.","mla":"Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters, vol. 315, no. 1–2, Elsevier, 2001, pp. 93–97, doi:10.1016/S0304-3940(01)02321-7.","ieee":"J. Li et al., “Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat,” Neuroscience Letters, vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.","short":"J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno, Neuroscience Letters 315 (2001) 93–97.","apa":"Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., & Mizuno, N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/S0304-3940(01)02321-7","ama":"Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience Letters. 2001;315(1-2):93-97. doi:10.1016/S0304-3940(01)02321-7"},"title":"Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in the rat","article_processing_charge":"No","external_id":{"pmid":["11711223"]},"author":[{"first_name":"Jin","last_name":"Li","full_name":"Li, Jin"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Ákos","full_name":"Kulik, Ákos","last_name":"Kulik"},{"last_name":"Chen","full_name":"Chen, Peng","first_name":"Peng"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"last_name":"Kaneko","full_name":"Kaneko, Takeshi","first_name":"Takeshi"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"publist_id":"4287","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0304-3940"]},"issue":"1-2","volume":315,"pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR) subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons (MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy, the immunogold-silver method for GABABR1 was combined with the immunoperoxidase method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were rarely associated with synaptic membrane specialization or extrasynaptic sites of plasma membrane. It has been indicated that GABABR1 may not be transported to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1 in the cell body of the rat MTN neurons might not be involved in the synaptic transmission."}],"intvolume":" 315","month":"11","scopus_import":"1","extern":"1","date_updated":"2023-05-22T12:30:05Z","_id":"2612","status":"public","article_type":"original","type":"journal_article"},{"type":"book_chapter","status":"public","_id":"2709","publist_id":"4187","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"}],"article_processing_charge":"No","title":"Long time dynamics of an electron in a weakly coupled phonon field","date_updated":"2023-05-22T12:11:29Z","citation":{"chicago":"Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon Field.” In 13th International Congress of Mathematical Physics, 273–81. International Press of Boston, 2001.","ista":"Erdös L. 2001.Long time dynamics of an electron in a weakly coupled phonon field. In: 13th International Congress of Mathematical Physics. , 273–281.","mla":"Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon Field.” 13th International Congress of Mathematical Physics, International Press of Boston, 2001, pp. 273–81.","short":"L. Erdös, in:, 13th International Congress of Mathematical Physics, International Press of Boston, 2001, pp. 273–281.","ieee":"L. Erdös, “Long time dynamics of an electron in a weakly coupled phonon field,” in 13th International Congress of Mathematical Physics, International Press of Boston, 2001, pp. 273–281.","apa":"Erdös, L. (2001). Long time dynamics of an electron in a weakly coupled phonon field. In 13th International Congress of Mathematical Physics (pp. 273–281). International Press of Boston.","ama":"Erdös L. Long time dynamics of an electron in a weakly coupled phonon field. In: 13th International Congress of Mathematical Physics. International Press of Boston; 2001:273-281."},"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":" International Press of Boston","quality_controlled":"1","month":"01","oa_version":"None","page":"273 - 281","date_published":"2001-01-01T00:00:00Z","date_created":"2018-12-11T11:59:11Z","publication_identifier":{"isbn":["9781571460851"]},"publication_status":"published","year":"2001","day":"01","language":[{"iso":"eng"}],"publication":"13th International Congress of Mathematical Physics"},{"publication":"Journal of Neuroscience","day":"15","year":"2001","date_created":"2018-12-11T11:58:39Z","date_published":"2001-11-15T00:00:00Z","doi":"10.1523/JNEUROSCI.21-22-08734.2001","page":"8734 - 8745","acknowledgement":"This work was supported in part by the Biotechnology and Biological Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8 cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination of brain sections, Christoph Wiessner for help with plots and statistics, Valerie Schuler for help with Western blots, and the team of the Novartis special strain breeding facility for their support.","oa":1,"quality_controlled":"1","publisher":"Society for Neuroscience","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"short":"G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder, D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten, Journal of Neuroscience 21 (2001) 8734–8745.","ieee":"G. Sansig et al., “Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no. 22. Society for Neuroscience, pp. 8734–8745, 2001.","ama":"Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745. doi:10.1523/JNEUROSCI.21-22-08734.2001","apa":"Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C., … Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001","mla":"Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001.","ista":"Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 21(22), 8734–8745.","chicago":"Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev, Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001."},"title":"Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7","article_processing_charge":"No","external_id":{"pmid":["11698585"]},"publist_id":"4288","author":[{"first_name":"Gilles","full_name":"Sansig, Gilles","last_name":"Sansig"},{"first_name":"Trevor","last_name":"Bushell","full_name":"Bushell, Trevor"},{"first_name":"Vernon","last_name":"Clarke","full_name":"Clarke, Vernon"},{"last_name":"Rozov","full_name":"Rozov, Andrei","first_name":"Andrei"},{"full_name":"Burnashev, Nail","last_name":"Burnashev","first_name":"Nail"},{"full_name":"Portet, Chantal","last_name":"Portet","first_name":"Chantal"},{"first_name":"Fabrizio","last_name":"Gasparini","full_name":"Gasparini, Fabrizio"},{"last_name":"Schmutz","full_name":"Schmutz, Markus","first_name":"Markus"},{"first_name":"Klaus","full_name":"Klebs, Klaus","last_name":"Klebs"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"last_name":"Flor","full_name":"Flor, Peter","first_name":"Peter"},{"first_name":"Rainer","full_name":"Kühn, Rainer","last_name":"Kühn"},{"last_name":"Knoepfel","full_name":"Knoepfel, Thomas","first_name":"Thomas"},{"full_name":"Schroeder, Markus","last_name":"Schroeder","first_name":"Markus"},{"first_name":"David","last_name":"Hampson","full_name":"Hampson, David"},{"full_name":"Collett, Valerie","last_name":"Collett","first_name":"Valerie"},{"first_name":"Congxiao","full_name":"Zhang, Congxiao","last_name":"Zhang"},{"last_name":"Duvoisin","full_name":"Duvoisin, Robert","first_name":"Robert"},{"first_name":"Graham","full_name":"Collingridge, Graham","last_name":"Collingridge"},{"full_name":"Van Der Putten, Herman","last_name":"Van Der Putten","first_name":"Herman"}],"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0270-6474"]},"issue":"22","volume":21,"oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng","text":"To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed no major changes in synaptic properties in two slice preparations. However, slightly increased excitability was evident in hippocampal slices. In addition, there was slower recovery from frequency facilitation in cortical slices, suggesting a role for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs."}],"intvolume":" 21","month":"11","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/"}],"scopus_import":"1","extern":"1","date_updated":"2023-05-24T08:47:53Z","_id":"2610","status":"public","type":"journal_article","article_type":"original"},{"citation":{"chicago":"Tamaru, Y, Sakashi Nomura, Noboru Mizuno, and Ryuichi Shigemoto. “Distribution of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00305-0.","ista":"Tamaru Y, Nomura S, Mizuno N, Shigemoto R. 2001. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. Neuroscience. 106(3), 481–503.","mla":"Tamaru, Y., et al. “Distribution of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.” Neuroscience, vol. 106, no. 3, Elsevier, 2001, pp. 481–503, doi:10.1016/S0306-4522(01)00305-0.","apa":"Tamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001). Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00305-0","ama":"Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites. Neuroscience. 2001;106(3):481-503. doi:10.1016/S0306-4522(01)00305-0","short":"Y. Tamaru, S. Nomura, N. Mizuno, R. Shigemoto, Neuroscience 106 (2001) 481–503.","ieee":"Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto, “Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites,” Neuroscience, vol. 106, no. 3. Elsevier, pp. 481–503, 2001."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4289","author":[{"full_name":"Tamaru, Y","last_name":"Tamaru","first_name":"Y"},{"last_name":"Nomura","full_name":"Nomura, Sakashi","first_name":"Sakashi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"}],"article_processing_charge":"No","external_id":{"pmid":["11591452"]},"title":"Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites","acknowledgement":"We are grateful to M. Yokoi and S. Nakanishi for kindly providing us with the mGluR2-de¢cient mice and F. Ferraguti for mGluR8b cDNA. The technical assistance of S. Doi and the photographic assistance of A. Uesugi are acknowledged. This work has been supported by research grants from the Ministry of Education, Sports, Culture, Science, and Technology of Japan.","publisher":"Elsevier","quality_controlled":"1","year":"2001","day":"27","publication":"Neuroscience","page":"481 - 503","doi":"10.1016/S0306-4522(01)00305-0","date_published":"2001-09-27T00:00:00Z","date_created":"2018-12-11T11:58:39Z","_id":"2609","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-24T08:51:17Z","extern":"1","abstract":[{"lang":"eng","text":"The metabotropic glutamate receptors (mGluRs) have distinct distribution patterns in the CNS but subtypes within group I or group III mGluRs share similar ultrastructural localization relative to neurotransmitter release sites: group I mGluRs are concentrated in an annulus surrounding the edge of the postsynaptic density, whereas group III mGluRs are concentrated in the presynaptic active zone. One of the group II subtypes, mGluR2, is expressed in both pre- and postsynaptic elements, having no close association with synapses. In order to determine if such a distribution is common to another group II subtype, mGluR3, an antibody was raised against a carboxy-terminus of mGluR3 and used for light and electron microscopic immunohistochemistry in the mouse CNS. The antibody reacted strongly with mGluR3, but it also reacted, though only weakly, with mGluR2. Therefore, to examine mGluR3-selective distribution, we used mGluR2-deficient mice as well as wild-type mice. Strong immunoreactivity for mGluR3 was found in the cerebral cortex, striatum, dentate gyrus of the hippocampus, olfactory tubercle, lateral septal nucleus, lateral and basolateral amygdaloid nuclei, and nucleus of the lateral olfactory tract. Pre-embedding immunoperoxidase and immunogold methods revealed mGluR3 labeling in both presynaptic and postsynaptic elements, and also in glial profiles. Double labeling revealed that the vast majority of mGluR3 in presynaptic elements is not closely associated with glutamate and GABA release sites in the striatum and thalamus, respectively. However, in the spines of the dentate granule cells, the highest receptor density was found in perisynaptic sites (20% of immunogold particles within 60 nm from the edge of postsynaptic membrane specialization) followed by a decreasing receptor density away from the synapses (to ∼5% of particles per 60 nm). Furthermore, 19% of immunogold particles were located in asymmetrical postsynaptic specialization, indicating an association of mGluR3 to glutamatergic synapses. The present results indicate that the localization of mGluR3 is rather similar to that of group I mGluRs in the postsynaptic elements, suggesting a unique functional role of mGluR3 in glutamatergic neurotransmission in the CNS."}],"oa_version":"None","pmid":1,"scopus_import":"1","month":"09","intvolume":" 106","publication_identifier":{"issn":["0306-4522"]},"publication_status":"published","language":[{"iso":"eng"}],"volume":106,"issue":"3"},{"year":"2001","publication":"Neuroscience","day":"27","page":"413 - 429","date_created":"2018-12-11T11:58:39Z","date_published":"2001-07-27T00:00:00Z","doi":"10.1016/S0306-4522(01)00188-9","acknowledgement":"öWe thank Drs. Paul Bolam, Ole Paulsen, Je¡ McIlhinney, Alfonso Faire¨n and Francisco Ciruela for reviewing a previous version of this manuscript and Mrs Alexandra Salewski for the English revision of the manuscript. We also want to thank Dr. Peter Somogyi for offering the facilities of the MRC Anatomical Neuropharmacology Unit to carry out part of this study. This work was supported by a Grant from the European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministry of Education (DGES PM 97-0082 to J.M.J.).","publisher":"Elsevier","quality_controlled":"1","citation":{"ista":"López Bendito G, Shigemoto R, Luján R, Juíz J. 2001. Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. Neuroscience. 105(2), 413–429.","chicago":"López Bendito, Guillermina, Ryuichi Shigemoto, Rafael Luján, and José Juíz. “Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00188-9.","ama":"López Bendito G, Shigemoto R, Luján R, Juíz J. Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. Neuroscience. 2001;105(2):413-429. doi:10.1016/S0306-4522(01)00188-9","apa":"López Bendito, G., Shigemoto, R., Luján, R., & Juíz, J. (2001). Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00188-9","ieee":"G. López Bendito, R. Shigemoto, R. Luján, and J. Juíz, “Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells,” Neuroscience, vol. 105, no. 2. Elsevier, pp. 413–429, 2001.","short":"G. López Bendito, R. Shigemoto, R. Luján, J. Juíz, Neuroscience 105 (2001) 413–429.","mla":"López Bendito, Guillermina, et al. “Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.” Neuroscience, vol. 105, no. 2, Elsevier, 2001, pp. 413–29, doi:10.1016/S0306-4522(01)00188-9."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["11672608 "]},"publist_id":"4290","author":[{"first_name":"Guillermina","full_name":"López Bendito, Guillermina","last_name":"López Bendito"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"José","last_name":"Juíz","full_name":"Juíz, José"}],"title":"Developmental changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje cells","publication_status":"published","publication_identifier":{"issn":["0306-4522"]},"language":[{"iso":"eng"}],"volume":105,"issue":"2","abstract":[{"lang":"eng","text":"The regulation of neurotransmitter receptors during synapse formation has been studied extensively at the neuromuscular junction, but little is known about the development of excitatory neurotransmitter receptors during synaptogenesis in central synapses. In this study we show qualitatively and quantitatively that a receptor undergoes changes in localisation on the surface of rat Purkinje cells during development in association with its excitatory synapses. The presence of mGluR1α at parallel and climbing fibre synapses on developing Purkinje cells was studied using high-resolution immunoelectron microscopy. Immunoreactivity for mGluR1α was detected from embryonic day 18 in Purkinje cells, and showed dramatic changes in its localisation with age. At early postnatal ages (P0 and P3), mGluR1α was found both in somata and stem dendrites but was not usually associated with synaptic contacts. At P7, mGluR1α became concentrated in somatic spines associated with climbing fibres and in the growing dendritic arborisation even before innervation by parallel fibres. During the second and third postnatal week, when spines and parallel fibre synapses were generated, mGluR1α became progressively concentrated in the molecular layer, particularly in the synaptic specialisations. As a result, during the fourth postnatal week, the pattern and level of mGluR1α expression became similar to the adult and mGluR1α appeared in high density in perisynaptic sites. Our results indicate that mGluR1α is present in the developing Purkinje cells prior to their innervation by climbing and parallel fibres and demonstrate that this receptor undergoes a dynamic and specific regulation during postnatal development in association with the establishment of synaptic inputs to Purkinje cell."}],"pmid":1,"oa_version":"None","scopus_import":"1","intvolume":" 105","month":"07","date_updated":"2023-05-24T09:31:48Z","extern":"1","_id":"2608","type":"journal_article","article_type":"original","status":"public"},{"title":"Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms","publist_id":"4291","author":[{"first_name":"Silvia","full_name":"Mion, Silvia","last_name":"Mion"},{"last_name":"Corti","full_name":"Corti, Corrado","first_name":"Corrado"},{"first_name":"Akio","full_name":"Neki, Akio","last_name":"Neki"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"first_name":"Mauro","full_name":"Corsi, Mauro","last_name":"Corsi"},{"full_name":"Fumagalli, Guido","last_name":"Fumagalli","first_name":"Guido"},{"last_name":"Ferraguti","full_name":"Ferraguti, Francesco","first_name":"Francesco"}],"external_id":{"pmid":["11414786"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Mion, Silvia, et al. “Bidirectional Regulation of Neurite Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” Molecular and Cellular Neuroscience, vol. 17, no. 6, Academic Press, 2001, pp. 957–72, doi:10.1006/mcne.2001.0993.","apa":"Mion, S., Corti, C., Neki, A., Shigemoto, R., Corsi, M., Fumagalli, G., & Ferraguti, F. (2001). Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. Academic Press. https://doi.org/10.1006/mcne.2001.0993","ama":"Mion S, Corti C, Neki A, et al. Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 2001;17(6):957-972. doi:10.1006/mcne.2001.0993","ieee":"S. Mion et al., “Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms,” Molecular and Cellular Neuroscience, vol. 17, no. 6. Academic Press, pp. 957–972, 2001.","short":"S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti, Molecular and Cellular Neuroscience 17 (2001) 957–972.","chicago":"Mion, Silvia, Corrado Corti, Akio Neki, Ryuichi Shigemoto, Mauro Corsi, Guido Fumagalli, and Francesco Ferraguti. “Bidirectional Regulation of Neurite Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” Molecular and Cellular Neuroscience. Academic Press, 2001. https://doi.org/10.1006/mcne.2001.0993.","ista":"Mion S, Corti C, Neki A, Shigemoto R, Corsi M, Fumagalli G, Ferraguti F. 2001. Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 17(6), 957–972."},"quality_controlled":"1","publisher":"Academic Press","acknowledgement":"The authors thank: Dr. J. M. Rimland and M. T. Scupoli for their technical help with X. oocytes recordings and FAC sorting, respectively; Dr. Y. Dalezios for helping with the statistical analyses; and Dr. G. Varani for helping with the analyses of mRNA and genomic sequences. We are also grateful to Professor F. Benfenati, Dr. F. Conquet, Dr. Rafael Lujan, Dr. J. McIlhinney, Professor P. Somogyi, Dr. J. H. Xuereb, and Dr. M. Zoli for careful reading of the manuscript\r\nand helpful suggestions. R.S. is supported by the Laboratory of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST Japan Science and Technology Corporation, Japan.","date_published":"2001-06-01T00:00:00Z","doi":"10.1006/mcne.2001.0993","date_created":"2018-12-11T11:58:38Z","page":"957 - 972","day":"01","publication":"Molecular and Cellular Neuroscience","year":"2001","status":"public","article_type":"original","type":"journal_article","_id":"2607","extern":"1","date_updated":"2023-05-24T09:34:13Z","month":"06","intvolume":" 17","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"Alternative splicing in the mGluR5 gene generates two different receptor isoforms, of which expression is developmentally regulated. However, little is known about the functional significance of mGluR5 splice variants. We have examined the functional coupling, subcellular targeting, and effect on neuronal differentiation of epitope-tagged mGluR5 isoforms by expression in neuroblastoma NG108-15 cells. We found that both mGluR5 splice variants give rise to comparable [Ca2+]i transients and have similar pharmacological profile. Tagged receptors were shown by immunofluorescence to be inserted in the plasma membrane. In undifferentiated cells the subcellular localization of the two mGluR5 isoforms was partially segregated, whereas in differentiated cells the labeling largely redistributed to the newly formed neurites. Interestingly, we demonstrate that mGluR5 splice variants dramatically influence the formation and maturation of neurites; mGluR5a hinders the acquisition of mature neuronal traits and mGluR5b fosters the elaboration and extension of neurites. These effects are partly inhibited by MPEP."}],"issue":"6","volume":17,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1044-7431"]},"publication_status":"published"},{"day":"10","publication":"Neuroscience","year":"2001","doi":"10.1016/S0306-4522(01)00058-6","date_published":"2001-05-10T00:00:00Z","date_created":"2018-12-11T11:58:38Z","page":"499 - 512","quality_controlled":"1","publisher":"Elsevier","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Geurts F, Timmermans J, Shigemoto R, De Schutter E. 2001. Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. Neuroscience. 104(2), 499–512.","chicago":"Geurts, Frederik, Jean Timmermans, Ryuichi Shigemoto, and Erik De Schutter. “Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons in the Adult Rat Cerebellum.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00058-6.","ieee":"F. Geurts, J. Timmermans, R. Shigemoto, and E. De Schutter, “Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum,” Neuroscience, vol. 104, no. 2. Elsevier, pp. 499–512, 2001.","short":"F. Geurts, J. Timmermans, R. Shigemoto, E. De Schutter, Neuroscience 104 (2001) 499–512.","ama":"Geurts F, Timmermans J, Shigemoto R, De Schutter E. Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. Neuroscience. 2001;104(2):499-512. doi:10.1016/S0306-4522(01)00058-6","apa":"Geurts, F., Timmermans, J., Shigemoto, R., & De Schutter, E. (2001). Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00058-6","mla":"Geurts, Frederik, et al. “Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons in the Adult Rat Cerebellum.” Neuroscience, vol. 104, no. 2, Elsevier, 2001, pp. 499–512, doi:10.1016/S0306-4522(01)00058-6."},"title":"Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum","author":[{"full_name":"Geurts, Frederik","last_name":"Geurts","first_name":"Frederik"},{"first_name":"Jean","full_name":"Timmermans, Jean","last_name":"Timmermans"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"De Schutter, Erik","last_name":"De Schutter","first_name":"Erik"}],"publist_id":"4292","external_id":{"pmid":["11377850"]},"article_processing_charge":"No","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0306-4522"]},"publication_status":"published","issue":"2","volume":104,"pmid":1,"oa_version":"None","abstract":[{"text":"The granular layer of the cerebellar cortex consists of densely packed neuronal cells, classified into granule cells and large interneurons. In this study, we provide a comparative survey of large granular layer interneurons in the adult rat cerebellum based on both morphological and neurochemical criteria. To this end, double immunofluorescence histochemistry was performed by combining antibodies against the cytoplasmic antigen Rat-303, calretinin, the metabotropic glutamate receptor mGluR2 and somatostatin. Based on Rat-303/calretinin double immunohistochemistry, three distinct populations of large granular layer interneurons could be discerned: cells immunopositive for Rat-303, calretinin or both. Rat-303 or calretinin single-labeled cells represented Golgi cells and unipolar brush cells, respectively. Rat-303/calretinin double-labeled cells located just underneath the Purkinje cell layer represented Lugaro cells. Morphometrical analysis distinguished two populations of Rat-303-positive Golgi cells according to their location: vermis versus hemisphere. Immunostaining for the metabotropic glutamate receptor mGluR2 combined with Rat-303 or calretinin revealed that the majority of Golgi cells (about 90%) appeared to be mGluR2 positive. Lugaro cells were mGluR2 negative. In addition, a limited population of large polymorphous interneurons in the depth of the granular layer with morphological features resembling Golgi cells also displayed Rat-303/calretinin immunoreactivity and were mGluR2 negative. Double immunohistochemistry for Rat-303 and somatostatin revealed three populations of labeled cells in the depth of the granular layer. Besides double-labeled Golgi cells, Rat-303 or somatostatin single-labeled cells were present. Based on mGluR2/somatostatin and calretinin/somatostatin double immunostainings, Rat-303 single-labeled cells were found to correspond to Rat-303/calretinin-positive, mGluR2-negative Golgi-like cells, while the identity of somatostatin single-labeled cells remained unclear. The data presented in this article elaborate previous reports on the morphological and neurochemical differentiation of large interneurons in the rat cerebellar granular layer. In addition, they indicate that the current classification of these cells into Golgi cells, Lugaro cells and unipolar brush cells does not describe the observed neurochemical heterogeneity.","lang":"eng"}],"month":"05","intvolume":" 104","scopus_import":"1","extern":"1","date_updated":"2023-05-24T12:45:30Z","_id":"2605","status":"public","article_type":"original","type":"journal_article"},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Ruocco, Isabella, et al. “Light and Electron Microscopic Study of the Distribution of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower Lip.” Journal of Comparative Neurology, vol. 432, no. 4, Wiley-Blackwell, 2001, pp. 466–80, doi:10.1002/cne.1114.","short":"I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Journal of Comparative Neurology 432 (2001) 466–480.","ieee":"I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip,” Journal of Comparative Neurology, vol. 432, no. 4. Wiley-Blackwell, pp. 466–480, 2001.","ama":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative Neurology. 2001;432(4):466-480. doi:10.1002/cne.1114","apa":"Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.1114","chicago":"Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro Da Silva. “Light and Electron Microscopic Study of the Distribution of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower Lip.” Journal of Comparative Neurology. Wiley-Blackwell, 2001. https://doi.org/10.1002/cne.1114.","ista":"Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative Neurology. 432(4), 466–480."},"title":"Light and electron microscopic study of the distribution of substance P-immunoreactive fibers and neurokinin-1 receptors in the skin of the rat lower lip","author":[{"full_name":"Ruocco, Isabella","last_name":"Ruocco","first_name":"Isabella"},{"full_name":"Cuello, Augusto","last_name":"Cuello","first_name":"Augusto"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"full_name":"Ribeiro Da Silva, Alfredo","last_name":"Ribeiro Da Silva","first_name":"Alfredo"}],"publist_id":"4294","external_id":{"pmid":["11268009"]},"article_processing_charge":"No","day":"16","publication":"Journal of Comparative Neurology","year":"2001","date_published":"2001-04-16T00:00:00Z","doi":"10.1002/cne.1114","date_created":"2018-12-11T11:58:37Z","page":"466 - 480","acknowledgement":"This work was sponsored by grant MT-12170 from the Canadian Medical Research Council. The authors thank Marie Ballak for electron microscopy assistance, Alan Forster for photographic expertise, and Sid Parkinson for editorial assistance.","quality_controlled":"1","publisher":"Wiley-Blackwell","extern":"1","date_updated":"2023-05-24T13:03:51Z","_id":"2604","status":"public","article_type":"original","type":"journal_article","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9967"]},"publication_status":"published","issue":"4","volume":432,"pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena that occur in neurogenic inflammation, are partially blocked by substance P (SP) receptor antagonists and are known to be mediated in part by mast cell-released substances, such as histamine, serotonin, and nitric oxide. In an attempt to provide a morphological substrate for the above phenomena, we applied light and electron microscopic immunocytochemistry to investigate the pattern of SP innervation of blood vessels and its relationship to mast cells in the skin of the rat lower lip. Furthermore, we examined the distribution of SP (neurokinin-1) receptors and their relationship to SP-immunoreactive (IR) fibers. Our results confirmed that SP-IR fibers are found in cutaneous nerves and that terminal branches are observed around blood vessels and penetrating the epidermis. SP-IR fibers also innervated hair follicles and sebaceous glands. At the ultrastructural level, SP-IR varicosities were observed adjacent to arterioles, capillaries, venules, and mast cells. The varicosities possessed both dense core vesicles and agranular synaptic vesicles. We quantified the distance between SP-IR varicosities and blood vessel endothelial cells. SP-IR terminals were located within 0.23-5.99 μm from the endothelial cell layer in 82.7% of arterioles, in 90.2% of capillaries, and in 86.9% of venules. Although there was a trend for SP-IR fibers to be located closer to the endothelium of venules, this difference was not significant. Neurokinin-1 receptor (NK-1r) immunoreactivity was most abundant in the upper dermis and was associated with the wall of blood vessels. NK-1r were located in equal amounts on the walls of arterioles, capillaries, and venules that were innervated by SP-IR fibers. The present results favor the concept of a participation of SP in cutaneous neurogenic vasodilatation and plasma extravasation both by an action on blood vessels after binding to the NK-1r and by causing the release of substances from mast cells after diffusion through the connective tissue."}],"month":"04","intvolume":" 432","scopus_import":"1"},{"acknowledgement":"MV and AF are senior coauthors of this work, which was supported by Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial de R+D AE98-18 from Generalitat Valenciana, and a Fellowship from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his G10 antireelin antibody and Roberto Gallego, Juan M. Luque and Felix Viana for their constructive criticisms on previous versions of the manuscript.","quality_controlled":"1","publisher":"Wiley-Blackwell","year":"2001","publication":"European Journal of Neuroscience","day":"01","page":"1147 - 1154","date_created":"2018-12-11T11:58:38Z","date_published":"2001-03-01T00:00:00Z","doi":"10.1046/j.0953-816X.2001.01494.x","citation":{"mla":"Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” European Journal of Neuroscience, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54, doi:10.1046/j.0953-816X.2001.01494.x.","ama":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience. 2001;13(6):1147-1154. doi:10.1046/j.0953-816X.2001.01494.x","apa":"Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., & Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816X.2001.01494.x","short":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos, European Journal of Neuroscience 13 (2001) 1147–1154.","ieee":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos, “Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors,” European Journal of Neuroscience, vol. 13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.","chicago":"Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto, Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” European Journal of Neuroscience. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.0953-816X.2001.01494.x.","ista":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience. 13(6), 1147–1154."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["11285012"]},"article_processing_charge":"No","author":[{"first_name":"Galán","last_name":"Martínez","full_name":"Martínez, Galán"},{"full_name":"López Bendito, Guillermina","last_name":"López Bendito","first_name":"Guillermina"},{"first_name":"Rafael","last_name":"Luján","full_name":"Luján, Rafael"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"full_name":"Fairén, Alfonso","last_name":"Fairén","first_name":"Alfonso"},{"first_name":"Miguel","last_name":"Valdeolmillos","full_name":"Valdeolmillos, Miguel"}],"publist_id":"4293","title":"Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors","abstract":[{"lang":"eng","text":"Glutamate receptors have been linked to the regulation of several developmental events in the CNS. By using cortical slices of early postnatal mice, we show that in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution of mGluRs to these responses was demonstrated by application of tACPD, an agonist to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs, elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius (Reelin-immunoreactive) neurons."}],"pmid":1,"oa_version":"None","scopus_import":"1","intvolume":" 13","month":"03","publication_status":"published","publication_identifier":{"issn":["0953-816X"]},"language":[{"iso":"eng"}],"issue":"6","volume":13,"_id":"2606","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-05-24T12:53:46Z","extern":"1"},{"volume":26,"issue":"2","publication_identifier":{"issn":["0179-5376"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","month":"01","intvolume":" 26","abstract":[{"text":"For an absolutely continuous probability measure μ. on ℝd and a nonnegative integer k, let S̃k(μ, 0) denote the probability that the convex hull of k + d + 1 random points which are i.i.d. according to μ contains the origin 0. For d and k given, we determine a tight upper bound on S̃k(μ, 0), and we characterize the measures in ℝd which attain this bound. As we will see, this result can be considered a continuous analogue of the Upper Bound Theorem for the maximal number of faces of convex polytopes with a given number of vertices. For our proof we introduce so-called h-functions, continuous counterparts of h-vectors of simplicial convex polytopes.","lang":"eng"}],"oa_version":"None","date_updated":"2023-05-24T13:13:51Z","extern":"1","article_type":"original","type":"journal_article","status":"public","_id":"2419","page":"205 - 219","doi":"10.1007/s00454-001-0028-9","date_published":"2001-01-01T00:00:00Z","date_created":"2018-12-11T11:57:33Z","year":"2001","day":"01","publication":"Discrete & Computational Geometry","quality_controlled":"1","publisher":"Springer","acknowledgement":"We are indebted to Rolf Schneider for many helpful remarks and in particular for bringing reference [6] to our attention","author":[{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568"},{"full_name":"Welzl, Emo","last_name":"Welzl","first_name":"Emo"}],"publist_id":"4506","article_processing_charge":"No","title":"A continuous analogue of the Upper Bound Theorem","citation":{"ista":"Wagner U, Welzl E. 2001. A continuous analogue of the Upper Bound Theorem. Discrete & Computational Geometry. 26(2), 205–219.","chicago":"Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.” Discrete & Computational Geometry. Springer, 2001. https://doi.org/10.1007/s00454-001-0028-9.","ieee":"U. Wagner and E. Welzl, “A continuous analogue of the Upper Bound Theorem,” Discrete & Computational Geometry, vol. 26, no. 2. Springer, pp. 205–219, 2001.","short":"U. Wagner, E. Welzl, Discrete & Computational Geometry 26 (2001) 205–219.","apa":"Wagner, U., & Welzl, E. (2001). A continuous analogue of the Upper Bound Theorem. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s00454-001-0028-9","ama":"Wagner U, Welzl E. A continuous analogue of the Upper Bound Theorem. Discrete & Computational Geometry. 2001;26(2):205-219. doi:10.1007/s00454-001-0028-9","mla":"Wagner, Uli, and Emo Welzl. “A Continuous Analogue of the Upper Bound Theorem.” Discrete & Computational Geometry, vol. 26, no. 2, Springer, 2001, pp. 205–19, doi:10.1007/s00454-001-0028-9."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0010-3616"]},"volume":217,"issue":"1","oa_version":"Preprint","abstract":[{"lang":"eng","text":"This paper concerns the asymptotic ground state properties of heavy atoms in strong, homogeneous magnetic fields. In the limit when the nuclear charge Z tends to ∞ with the magnetic field B satisfying B ≫ Z4/3 all the electrons are confined to the lowest Landau band. We consider here an energy functional, whose variable is a sequence of one-dimensional density matrices corresponding to different angular momentum functions in the lowest Landau band. We study this functional in detail and derive various interesting properties, which are compared with the density matrix (DM) theory introduced by Lieb, Solovej and Yngvason. In contrast to the DM theory the variable perpendicular to the field is replaced by the discrete angular momentum quantum numbers. Hence we call the new functional a discrete density matrix (DDM) functional. We relate this DDM theory to the lowest Landau band quantum mechanics and show that it reproduces correctly the ground state energy apart from errors due to the indirect part of the Coulomb interaction energy."}],"intvolume":" 217","month":"02","main_file_link":[{"url":"http://arxiv.org/abs/math-ph/0010005","open_access":"1"}],"scopus_import":"1","extern":"1","date_updated":"2023-05-30T06:54:54Z","_id":"2348","status":"public","article_type":"original","type":"journal_article","publication":"Communications in Mathematical Physics","day":"01","year":"2001","date_created":"2018-12-11T11:57:08Z","doi":"10.1007/s002200100373","date_published":"2001-02-01T00:00:00Z","page":"229 - 248","acknowledgement":"The authors would like to thank Bernhard Baumgartner and Jakob Yngvason for proofreading and valuable comments.","oa":1,"publisher":"Springer","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100373.","ista":"Hainzl C, Seiringer R. 2001. A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. 217(1), 229–248.","mla":"Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics, vol. 217, no. 1, Springer, 2001, pp. 229–48, doi:10.1007/s002200100373.","ieee":"C. Hainzl and R. Seiringer, “A discrete density matrix theory for atoms in strong magnetic fields,” Communications in Mathematical Physics, vol. 217, no. 1. Springer, pp. 229–248, 2001.","short":"C. Hainzl, R. Seiringer, Communications in Mathematical Physics 217 (2001) 229–248.","apa":"Hainzl, C., & Seiringer, R. (2001). A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100373","ama":"Hainzl C, Seiringer R. A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. 2001;217(1):229-248. doi:10.1007/s002200100373"},"title":"A discrete density matrix theory for atoms in strong magnetic fields","article_processing_charge":"No","external_id":{"arxiv":["math-ph/0010005"]},"publist_id":"4578","author":[{"full_name":"Hainzl, Christian","last_name":"Hainzl","first_name":"Christian"},{"full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}]},{"_id":"2347","type":"journal_article","article_type":"original","status":"public","date_updated":"2023-05-30T12:28:46Z","extern":"1","abstract":[{"lang":"eng","text":"We consider the ground state properties of an inhomogeneous two-dimensional Bose gas with a repulsive, short range pair interaction and an external confining potential. In the limit when the particle number N is large but ρ̅a 2 is small, where ρ̅ is the average particle density and a the scattering length, the ground state energy and density are rigorously shown to be given to leading order by a Gross–Pitaevskii (GP) energy functional with a coupling constant g~1/|1n(ρ̅a 2)|. In contrast to the 3D case the coupling constant depends on N through the mean density. The GP energy per particle depends only on Ng. In 2D this parameter is typically so large that the gradient term in the GP energy functional is negligible and the simpler description by a Thomas–Fermi type functional is adequate."}],"oa_version":"Published Version","main_file_link":[{"url":"http://arxiv.org/abs/cond-mat/0005026","open_access":"1"}],"scopus_import":"1","intvolume":" 224","month":"11","publication_status":"published","publication_identifier":{"issn":["0010-3616"]},"language":[{"iso":"eng"}],"volume":224,"issue":"1","citation":{"ista":"Lieb É, Seiringer R, Yngvason J. 2001. A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. 224(1), 17–31.","chicago":"Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “A Rigorous Derivation of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100533.","apa":"Lieb, É., Seiringer, R., & Yngvason, J. (2001). A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100533","ama":"Lieb É, Seiringer R, Yngvason J. A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. 2001;224(1):17-31. doi:10.1007/s002200100533","short":"É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics 224 (2001) 17–31.","ieee":"É. Lieb, R. Seiringer, and J. Yngvason, “A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas,” Communications in Mathematical Physics, vol. 224, no. 1. Springer, pp. 17–31, 2001.","mla":"Lieb, Élliott, et al. “A Rigorous Derivation of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical Physics, vol. 224, no. 1, Springer, 2001, pp. 17–31, doi:10.1007/s002200100533."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"arxiv":["cond-mat/0005026"]},"author":[{"full_name":"Lieb, Élliott","last_name":"Lieb","first_name":"Élliott"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"publist_id":"4579","title":"A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas","oa":1,"quality_controlled":"1","publisher":"Springer","year":"2001","publication":"Communications in Mathematical Physics","day":"01","page":"17 - 31","date_created":"2018-12-11T11:57:08Z","doi":"10.1007/s002200100533","date_published":"2001-11-01T00:00:00Z"},{"extern":"1","date_updated":"2023-05-30T12:37:44Z","status":"public","type":"journal_article","article_type":"original","_id":"2345","volume":34,"issue":"9","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0305-4470"]},"intvolume":" 34","month":"03","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0006002"}],"scopus_import":"1","oa_version":"None","abstract":[{"lang":"eng","text":"We give upper bounds for the number of spin-1/2 particles that can be bound to a nucleus of charge Z in the presence of a magnetic field B, including the spin-field coupling. We use Lieb's strategy, which is known to yield Nc < 2Z + 1 for magnetic fields that go to zero at infinity, ignoring the spin-field interaction. For particles with fermionic statistics in a homogeneous magnetic field our upper bound has an additional term of the order of Z × min {(B/Z3)2/5, 1 + | 1n(B/Z3)|2}."}],"title":"On the maximal ionization of atoms in strong magnetic fields","article_processing_charge":"No","external_id":{"arxiv":["math-ph/0006002"]},"author":[{"last_name":"Seiringer","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"4580","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic Fields.” Journal of Physics A: Mathematical and General, vol. 34, no. 9, IOP Publishing Ltd., 2001, pp. 1943–48, doi:10.1088/0305-4470/34/9/311.","ama":"Seiringer R. On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. 2001;34(9):1943-1948. doi:10.1088/0305-4470/34/9/311","apa":"Seiringer, R. (2001). On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. IOP Publishing Ltd. https://doi.org/10.1088/0305-4470/34/9/311","ieee":"R. Seiringer, “On the maximal ionization of atoms in strong magnetic fields,” Journal of Physics A: Mathematical and General, vol. 34, no. 9. IOP Publishing Ltd., pp. 1943–1948, 2001.","short":"R. Seiringer, Journal of Physics A: Mathematical and General 34 (2001) 1943–1948.","chicago":"Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic Fields.” Journal of Physics A: Mathematical and General. IOP Publishing Ltd., 2001. https://doi.org/10.1088/0305-4470/34/9/311.","ista":"Seiringer R. 2001. On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. 34(9), 1943–1948."},"date_created":"2018-12-11T11:57:07Z","doi":"10.1088/0305-4470/34/9/311","date_published":"2001-03-09T00:00:00Z","page":"1943 - 1948","publication":"Journal of Physics A: Mathematical and General","day":"09","year":"2001","oa":1,"quality_controlled":"1","publisher":"IOP Publishing Ltd."},{"date_updated":"2023-05-30T12:49:08Z","extern":"1","_id":"2341","article_type":"original","type":"journal_article","status":"public","publication_identifier":{"issn":["1424-0637"]},"publication_status":"published","language":[{"iso":"eng"}],"volume":2,"issue":"1","abstract":[{"lang":"eng","text":"We study the ground state properties of an atom with nuclear charge Z and N bosonic "electrons" in the presence of a homogeneous magnetic field B. We investigate the mean field limit N→∞ with N / Z fixed, and identify three different asymptotic regions, according to B≪Z2,B∼Z2,andB≫Z2 . In Region 1 standard Hartree theory is applicable. Region 3 is described by a one-dimensional functional, which is identical to the so-called Hyper-Strong functional introduced by Lieb, Solovej and Yngvason for atoms with fermionic electrons in the region B≫Z3 ; i.e., for very strong magnetic fields the ground state properties of atoms are independent of statistics. For Region 2 we introduce a general magnetic Hartree functional, which is studied in detail. It is shown that in the special case of an atom it can be restricted to the subspace of zero angular momentum parallel to the magnetic field, which simplifies the theory considerably. The functional reproduces the energy and the one-particle reduced density matrix for the full N-particle ground state to leading order in N, and it implies the description of the other regions as limiting cases."}],"oa_version":"None","scopus_import":"1","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0007007"}],"month":"02","intvolume":" 2","citation":{"chicago":"Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic "Electrons" in Strong Magnetic Fields.” Annales Henri Poincare. Birkhäuser, 2001. https://doi.org/10.1007/PL00001032.","ista":"Baumgartner B, Seiringer R. 2001. Atoms with bosonic "electrons" in strong magnetic fields. Annales Henri Poincare. 2(1), 41–76.","mla":"Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic "Electrons" in Strong Magnetic Fields.” Annales Henri Poincare, vol. 2, no. 1, Birkhäuser, 2001, pp. 41–76, doi:10.1007/PL00001032.","short":"B. Baumgartner, R. Seiringer, Annales Henri Poincare 2 (2001) 41–76.","ieee":"B. Baumgartner and R. Seiringer, “Atoms with bosonic "electrons" in strong magnetic fields,” Annales Henri Poincare, vol. 2, no. 1. Birkhäuser, pp. 41–76, 2001.","ama":"Baumgartner B, Seiringer R. Atoms with bosonic "electrons" in strong magnetic fields. Annales Henri Poincare. 2001;2(1):41-76. doi:10.1007/PL00001032","apa":"Baumgartner, B., & Seiringer, R. (2001). Atoms with bosonic "electrons" in strong magnetic fields. Annales Henri Poincare. Birkhäuser. https://doi.org/10.1007/PL00001032"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4585","author":[{"last_name":"Baumgartner","full_name":"Baumgartner, Bernhard","first_name":"Bernhard"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer"}],"external_id":{"arxiv":["math-ph/0007007"]},"article_processing_charge":"No","title":"Atoms with bosonic "electrons" in strong magnetic fields","year":"2001","day":"01","publication":"Annales Henri Poincare","page":"41 - 76","date_published":"2001-02-01T00:00:00Z","doi":"10.1007/PL00001032","date_created":"2018-12-11T11:57:06Z","quality_controlled":"1","publisher":"Birkhäuser","oa":1},{"oa":1,"publisher":"Springer","quality_controlled":"1","date_created":"2018-12-11T11:57:07Z","date_published":"2001-02-01T00:00:00Z","doi":"10.1023/A:1010951905548","page":"133 - 142","publication":"Letters in Mathematical Physics","day":"01","year":"2001","title":"Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics","article_processing_charge":"No","external_id":{"arxiv":["cond-mat/0102118"]},"author":[{"last_name":"Hainzl","full_name":"Hainzl, Christian","first_name":"Christian"},{"last_name":"Seiringer","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"4581","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters in Mathematical Physics. Springer, 2001. https://doi.org/10.1023/A:1010951905548.","ista":"Hainzl C, Seiringer R. 2001. Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. 55(2), 133–142.","mla":"Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters in Mathematical Physics, vol. 55, no. 2, Springer, 2001, pp. 133–42, doi:10.1023/A:1010951905548.","ieee":"C. Hainzl and R. Seiringer, “Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics,” Letters in Mathematical Physics, vol. 55, no. 2. Springer, pp. 133–142, 2001.","short":"C. Hainzl, R. Seiringer, Letters in Mathematical Physics 55 (2001) 133–142.","apa":"Hainzl, C., & Seiringer, R. (2001). Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. Springer. https://doi.org/10.1023/A:1010951905548","ama":"Hainzl C, Seiringer R. Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. 2001;55(2):133-142. doi:10.1023/A:1010951905548"},"intvolume":" 55","month":"02","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/cond-mat/0102118"}],"scopus_import":"1","oa_version":"Published Version","abstract":[{"text":"By means of a generalization of the Fefferman - de la Llave decomposition we derive a general lower bound on the interaction energy of one-dimensional quantum systems. We apply this result to a specific class of lowest Landau band wave functions.","lang":"eng"}],"volume":55,"issue":"2","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0377-9017"]},"status":"public","article_type":"original","type":"journal_article","_id":"2346","extern":"1","date_updated":"2023-05-30T12:44:05Z"},{"type":"conference","conference":{"name":"PDE: Partial Differential Equations and Spectral Theory","location":"Clausthal, Germany"},"status":"public","_id":"2340","date_updated":"2023-05-30T13:20:05Z","extern":"1","alternative_title":["Operator Theory: Advances and Applications"],"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0010006"}],"month":"01","intvolume":" 126","abstract":[{"text":"Recent experimental breakthroughs in the treatment of dilute Bose gases have renewed interest in their quantum mechanical description, respectively in approximations to it. The ground state properties of dilute Bose gases confined in external potentials and interacting via repulsive short range forces are usually described by means of the Gross-Pitaevskii energy functional. In joint work with Elliott H. Lieb and Jakob Yngvason its status as an approximation for the quantum mechanical many-body ground state problem has recently been rigorously clarified. We present a summary of this work, for both the two-and three-dimensional case.\r\n","lang":"eng"}],"oa_version":"None","volume":126,"publication_identifier":{"isbn":["9783034894838"]},"publication_status":"published","language":[{"iso":"eng"}],"author":[{"last_name":"Seiringer","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"4586","external_id":{"arxiv":["math-ph/0010006"]},"article_processing_charge":"No","title":"Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula","editor":[{"first_name":"Michael","full_name":"Demuth, Michael","last_name":"Demuth"},{"first_name":"Bert","last_name":"Schultze","full_name":"Schultze, Bert"}],"citation":{"mla":"Seiringer, Robert. Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii Ground State Energy Formula. Edited by Michael Demuth and Bert Schultze, vol. 126, Birkhäuser, 2001, pp. 307–14, doi:10.1007/978-3-0348-8231-6.","short":"R. Seiringer, in:, M. Demuth, B. Schultze (Eds.), Birkhäuser, 2001, pp. 307–314.","ieee":"R. Seiringer, “Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula,” presented at the PDE: Partial Differential Equations and Spectral Theory, Clausthal, Germany, 2001, vol. 126, pp. 307–314.","apa":"Seiringer, R. (2001). Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. In M. Demuth & B. Schultze (Eds.) (Vol. 126, pp. 307–314). Presented at the PDE: Partial Differential Equations and Spectral Theory, Clausthal, Germany: Birkhäuser. https://doi.org/10.1007/978-3-0348-8231-6","ama":"Seiringer R. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. In: Demuth M, Schultze B, eds. Vol 126. Birkhäuser; 2001:307-314. doi:10.1007/978-3-0348-8231-6","chicago":"Seiringer, Robert. “Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii Ground State Energy Formula.” edited by Michael Demuth and Bert Schultze, 126:307–14. Birkhäuser, 2001. https://doi.org/10.1007/978-3-0348-8231-6.","ista":"Seiringer R. 2001. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. PDE: Partial Differential Equations and Spectral Theory, Operator Theory: Advances and Applications, vol. 126, 307–314."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","publisher":"Birkhäuser","oa":1,"page":"307 - 314","date_published":"2001-01-01T00:00:00Z","doi":"10.1007/978-3-0348-8231-6","date_created":"2018-12-11T11:57:05Z","year":"2001","day":"01"},{"publist_id":"5742","author":[{"first_name":"Tamas","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","last_name":"Hausel","full_name":"Hausel, Tamas"},{"first_name":"Michael","last_name":"Thaddeus","full_name":"Thaddeus, Michael"}],"article_processing_charge":"No","external_id":{"arxiv":["math/0106140"]},"title":"Examples of mirror partners arising from integrable systems","citation":{"ama":"Hausel T, Thaddeus M. Examples of mirror partners arising from integrable systems. Comptes Rendus de l’Academie des Sciences - Series I: Mathematics. 2001;333(4):313-318. doi:10.1016/S0764-4442(01)02057-2","apa":"Hausel, T., & Thaddeus, M. (2001). Examples of mirror partners arising from integrable systems. Comptes Rendus de l’Academie Des Sciences - Series I: Mathematics. Elsevier. https://doi.org/10.1016/S0764-4442(01)02057-2","ieee":"T. Hausel and M. Thaddeus, “Examples of mirror partners arising from integrable systems,” Comptes Rendus de l’Academie des Sciences - Series I: Mathematics, vol. 333, no. 4. Elsevier, pp. 313–318, 2001.","short":"T. Hausel, M. Thaddeus, Comptes Rendus de l’Academie Des Sciences - Series I: Mathematics 333 (2001) 313–318.","mla":"Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising from Integrable Systems.” Comptes Rendus de l’Academie Des Sciences - Series I: Mathematics, vol. 333, no. 4, Elsevier, 2001, pp. 313–18, doi:10.1016/S0764-4442(01)02057-2.","ista":"Hausel T, Thaddeus M. 2001. Examples of mirror partners arising from integrable systems. Comptes Rendus de l’Academie des Sciences - Series I: Mathematics. 333(4), 313–318.","chicago":"Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising from Integrable Systems.” Comptes Rendus de l’Academie Des Sciences - Series I: Mathematics. Elsevier, 2001. https://doi.org/10.1016/S0764-4442(01)02057-2."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"313 - 318","doi":"10.1016/S0764-4442(01)02057-2","date_published":"2001-08-15T00:00:00Z","date_created":"2018-12-11T11:52:06Z","year":"2001","day":"15","publication":"Comptes Rendus de l'Academie des Sciences - Series I: Mathematics","quality_controlled":"1","publisher":"Elsevier","oa":1,"acknowledgement":"The authors are grateful for Nigel Hitchin for suggesting the similarity between [4] and [12] in 1996 and for Pierre Deligne for numerous useful comments","date_updated":"2023-05-31T09:57:48Z","extern":"1","type":"journal_article","article_type":"original","status":"public","_id":"1452","volume":333,"issue":"4","publication_identifier":{"issn":["0764-4442"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","main_file_link":[{"url":"http://arxiv.org/abs/math/0106140","open_access":"1"}],"month":"08","intvolume":" 333","abstract":[{"text":"In this Note we present pairs of hyperkähler orbifolds which satisfy two different versions of mirror symmetry. On the one hand, we show that their Hodge numbers (or more precisely, stringy E-polynomials) are equal. On the other hand, we show that they satisfy the prescription of Strominger, Yau, and Zaslow (which in the present case goes back to Bershadsky, Johansen, Sadov and Vafa): that a Calabi-Yau and its mirror should fiber over the same real manifold, with special Lagrangian fibers which are tori dual to each other. Our examples arise as moduli spaces of local systems on a curve with structure group SL(n); the mirror is the corresponding space with structure group PGL(n). The special Lagrangian tori come from an algebraically completely integrable Hamiltonian system: the Hitchin system.","lang":"eng"}],"oa_version":"Preprint"}]