---
_id: '11126'
abstract:
- lang: eng
text: Nuclear import of the two uracil-rich small nuclear ribonucleoprotein (U snRNP)
components U1A and U2B′′ is mediated by unusually long and complex nuclear localization
signals (NLSs). Here we investigate nuclear import of U1A and U2B′′ in vitro and
demonstrate that it occurs by an active, saturable process. Several lines of evidence
suggest that import of the two proteins occurs by an import mechanism different
to those characterized previously. No cross competition is seen with a variety
of previously studied NLSs. In contrast to import mediated by members of the importin-β
family of nucleocytoplasmic transport receptors, U1A/U2B′′ import is not inhibited
by either nonhydrolyzable guanosine triphosphate (GTP) analogues or by a mutant
of the GTPase Ran that is incapable of GTP hydrolysis. Adenosine triphosphate
is capable of supporting U1A and U2B′′ import, whereas neither nonhydrolyzable
adenosine triphosphate analogues nor GTP can do so. U1A and U2B′′ import in vitro
does not require the addition of soluble cytosolic proteins, but a factor or factors
required for U1A and U2B′′ import remains tightly associated with the nuclear
fraction of conventionally permeabilized cells. This activity can be solubilized
in the presence of elevated MgCl2. These data suggest that U1A and U2B′′ import
into the nucleus occurs by a hitherto uncharacterized mechanism.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
citation:
ama: Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear
import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology.
2000;148(2):293-304. doi:10.1083/jcb.148.2.293
apa: Hetzer, M., & Mattaj, I. W. (2000). An Atp-dependent, Ran-independent mechanism
for nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell
Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.148.2.293
chicago: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent
Mechanism for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” Journal
of Cell Biology. Rockefeller University Press, 2000. https://doi.org/10.1083/jcb.148.2.293.
ieee: M. Hetzer and I. W. Mattaj, “An Atp-dependent, Ran-independent mechanism for
nuclear import of the U1a and U2b′′ spliceosome proteins,” Journal of Cell
Biology, vol. 148, no. 2. Rockefeller University Press, pp. 293–304, 2000.
ista: Hetzer M, Mattaj IW. 2000. An Atp-dependent, Ran-independent mechanism for
nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology.
148(2), 293–304.
mla: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent Mechanism
for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” Journal of Cell
Biology, vol. 148, no. 2, Rockefeller University Press, 2000, pp. 293–304,
doi:10.1083/jcb.148.2.293.
short: M. Hetzer, I.W. Mattaj, Journal of Cell Biology 148 (2000) 293–304.
date_created: 2022-04-07T07:57:49Z
date_published: 2000-01-24T00:00:00Z
date_updated: 2022-07-18T08:58:29Z
day: '24'
doi: 10.1083/jcb.148.2.293
extern: '1'
external_id:
pmid:
- '10648562'
intvolume: ' 148'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 293-304
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and
U2b′′ spliceosome proteins
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 148
year: '2000'
...
---
_id: '11127'
abstract:
- lang: eng
text: Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited
by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE)
vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran
GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for
Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion
can be complemented by the addition of Ran loaded with either GTP or GDP but not
with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus,
generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the
extensive membrane fusion events that lead to NE formation.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Daniel
full_name: Bilbao-Cortés, Daniel
last_name: Bilbao-Cortés
- first_name: Tobias C
full_name: Walther, Tobias C
last_name: Walther
- first_name: Oliver J
full_name: Gruss, Oliver J
last_name: Gruss
- first_name: Iain W
full_name: Mattaj, Iain W
last_name: Mattaj
citation:
ama: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024.
doi:10.1016/s1097-2765(00)80266-x
apa: Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., & Mattaj,
I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly.
Molecular Cell. Elsevier. https://doi.org/10.1016/s1097-2765(00)80266-x
chicago: Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss,
and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.”
Molecular Cell. Elsevier, 2000. https://doi.org/10.1016/s1097-2765(00)80266-x.
ieee: M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj,
“GTP hydrolysis by Ran is required for nuclear envelope assembly,” Molecular
Cell, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000.
ista: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.
mla: Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope
Assembly.” Molecular Cell, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24,
doi:10.1016/s1097-2765(00)80266-x.
short: M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular
Cell 5 (2000) 1013–1024.
date_created: 2022-04-07T07:57:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-07-18T08:58:31Z
day: '01'
doi: 10.1016/s1097-2765(00)80266-x
extern: '1'
external_id:
pmid:
- '10911995'
intvolume: ' 5'
issue: '6'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S1097-2765(00)80266-X
month: '06'
oa: 1
oa_version: Published Version
page: 1013-1024
pmid: 1
publication: Molecular Cell
publication_identifier:
issn:
- 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GTP hydrolysis by Ran is required for nuclear envelope assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 5
year: '2000'
...
---
_id: '11683'
abstract:
- lang: eng
text: The vertex connectivity κ of a graph is the smallest number of vertices whose
deletion separates the graph or makes it trivial. We present the fastest known
deterministic algorithm for finding the vertex connectivity and a corresponding
separator. The time for a digraph having n vertices and m edges is O(min{κ3 +
n, κn}m); for an undirected graph the term m can be replaced by κn. A randomized
algorithm finds κ with error probability 1/2 in time O(nm). If the vertices have
nonnegative weights the weighted vertex connectivity is found in time O(κ1nmlog(n2/m))
where κ1 ≤ m/n is the unweighted vertex connectivity or in expected time O(nmlog(n2/m))
with error probability 1/2. The main algorithm combines two previous vertex connectivity
algorithms and a generalization of the preflow-push algorithm of Hao and Orlin
(1994, J. Algorithms17, 424–446) that computes edge connectivity.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Harold N.
full_name: Gabow, Harold N.
last_name: Gabow
citation:
ama: 'Henzinger MH, Rao S, Gabow HN. Computing vertex connectivity: New bounds from
old techniques. Journal of Algorithms. 2000;34(2):222-250. doi:10.1006/jagm.1999.1055'
apa: 'Henzinger, M. H., Rao, S., & Gabow, H. N. (2000). Computing vertex connectivity:
New bounds from old techniques. Journal of Algorithms. Elsevier. https://doi.org/10.1006/jagm.1999.1055'
chicago: 'Henzinger, Monika H, Satish Rao, and Harold N. Gabow. “Computing Vertex
Connectivity: New Bounds from Old Techniques.” Journal of Algorithms. Elsevier,
2000. https://doi.org/10.1006/jagm.1999.1055.'
ieee: 'M. H. Henzinger, S. Rao, and H. N. Gabow, “Computing vertex connectivity:
New bounds from old techniques,” Journal of Algorithms, vol. 34, no. 2.
Elsevier, pp. 222–250, 2000.'
ista: 'Henzinger MH, Rao S, Gabow HN. 2000. Computing vertex connectivity: New bounds
from old techniques. Journal of Algorithms. 34(2), 222–250.'
mla: 'Henzinger, Monika H., et al. “Computing Vertex Connectivity: New Bounds from
Old Techniques.” Journal of Algorithms, vol. 34, no. 2, Elsevier, 2000,
pp. 222–50, doi:10.1006/jagm.1999.1055.'
short: M.H. Henzinger, S. Rao, H.N. Gabow, Journal of Algorithms 34 (2000) 222–250.
date_created: 2022-07-28T08:56:10Z
date_published: 2000-02-01T00:00:00Z
date_updated: 2022-09-12T09:06:48Z
day: '01'
doi: 10.1006/jagm.1999.1055
extern: '1'
intvolume: ' 34'
issue: '2'
keyword:
- Computational Theory and Mathematics
- Computational Mathematics
- Control and Optimization
language:
- iso: eng
month: '02'
oa_version: None
page: 222-250
publication: Journal of Algorithms
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Computing vertex connectivity: New bounds from old techniques'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2000'
...
---
_id: '11685'
abstract:
- lang: eng
text: We consider the problem of sampling URLs uniformly at random from the Web.
A tool for sampling URLs uniformly can be used to estimate various properties
of Web pages, such as the fraction of pages in various Internet domains or written
in various languages. Moreover, uniform URL sampling can be used to determine
the sizes of various search engines relative to the entire Web. In this paper,
we consider sampling approaches based on random walks of the Web graph. In particular,
we suggest ways of improving sampling based on random walks to make the samples
closer to uniform. We suggest a natural test bed based on random graphs for testing
the effectiveness of our procedures. We then use our sampling approach to estimate
the distribution of pages over various Internet domains and to estimate the coverage
of various search engine indexes.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Allan
full_name: Heydon, Allan
last_name: Heydon
- first_name: Michael
full_name: Mitzenmacher, Michael
last_name: Mitzenmacher
- first_name: Marc
full_name: Najork, Marc
last_name: Najork
citation:
ama: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. On near-uniform URL sampling.
Computer Networks. 2000;33(1-6):295-308. doi:10.1016/s1389-1286(00)00055-4
apa: Henzinger, M. H., Heydon, A., Mitzenmacher, M., & Najork, M. (2000). On
near-uniform URL sampling. Computer Networks. Elsevier. https://doi.org/10.1016/s1389-1286(00)00055-4
chicago: Henzinger, Monika H, Allan Heydon, Michael Mitzenmacher, and Marc Najork.
“On Near-Uniform URL Sampling.” Computer Networks. Elsevier, 2000. https://doi.org/10.1016/s1389-1286(00)00055-4.
ieee: M. H. Henzinger, A. Heydon, M. Mitzenmacher, and M. Najork, “On near-uniform
URL sampling,” Computer Networks, vol. 33, no. 1–6. Elsevier, pp. 295–308,
2000.
ista: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. 2000. On near-uniform URL
sampling. Computer Networks. 33(1–6), 295–308.
mla: Henzinger, Monika H., et al. “On Near-Uniform URL Sampling.” Computer Networks,
vol. 33, no. 1–6, Elsevier, 2000, pp. 295–308, doi:10.1016/s1389-1286(00)00055-4.
short: M.H. Henzinger, A. Heydon, M. Mitzenmacher, M. Najork, Computer Networks
33 (2000) 295–308.
date_created: 2022-07-28T15:11:53Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-09-12T09:09:13Z
day: '01'
doi: 10.1016/s1389-1286(00)00055-4
extern: '1'
intvolume: ' 33'
issue: 1-6
keyword:
- URL sampling
- Random walks
- Internet domain distribution
- Search engine size
language:
- iso: eng
month: '06'
oa_version: None
page: 295-308
publication: Computer Networks
publication_identifier:
issn:
- 1389-1286
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On near-uniform URL sampling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2000'
...
---
_id: '11694'
abstract:
- lang: eng
text: We consider exploration problems where a robot has to construct a complete
map of an unknown environment. We assume that the environment is modeled by a
directed, strongly connected graph. The robot's task is to visit all nodes and
edges of the graph using the minimum number R of edge traversals. Deng and Papadimitriou
[Proceedings of the 31st Symposium on the Foundations of Computer Science, 1990,
pp. 356-361] showed an upper bound for R ofd O(d)m and Koutsoupias (reported by
Deng and Papadimitriou) gave a lower bound of Ω≠(d2m), where m is the number of
edges in the graph and d is the minimum number of edges that have to be added
to make the graph Eulerian. We give the 1rst subexponential algorithm for this
exploration problem, which achieves an upper bound of dO(logd)m. We also show
a matching lower bound of d≠(logd)m for our algorithm. Additionally, we give lower
bounds of 2≠(d)m, respectively, d≠(logd)m for various other natural exploration
algorithms.
acknowledgement: We thank Prabhakar Raghavan for bringing to our attention the literature
on the s-t connectivity problem. We also thank an anonymous referee for many helpful
comments which improved the presentation of the paper.
article_processing_charge: No
article_type: original
author:
- first_name: Susanne
full_name: Albers, Susanne
last_name: Albers
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Albers S, Henzinger MH. Exploring unknown environments. SIAM Journal on
Computing. 2000;29(4):1164-1188. doi:10.1137/s009753979732428x
apa: 'Albers, S., & Henzinger, M. H. (2000). Exploring unknown environments.
SIAM Journal on Computing. El Paso, TX, United States: Society for Industrial
and Applied Mathematics. https://doi.org/10.1137/s009753979732428x'
chicago: Albers, Susanne, and Monika H Henzinger. “Exploring Unknown Environments.”
SIAM Journal on Computing. Society for Industrial and Applied Mathematics,
2000. https://doi.org/10.1137/s009753979732428x.
ieee: S. Albers and M. H. Henzinger, “Exploring unknown environments,” SIAM Journal
on Computing, vol. 29, no. 4. Society for Industrial and Applied Mathematics,
pp. 1164–1188, 2000.
ista: Albers S, Henzinger MH. 2000. Exploring unknown environments. SIAM Journal
on Computing. 29(4), 1164–1188.
mla: Albers, Susanne, and Monika H. Henzinger. “Exploring Unknown Environments.”
SIAM Journal on Computing, vol. 29, no. 4, Society for Industrial and Applied
Mathematics, 2000, pp. 1164–88, doi:10.1137/s009753979732428x.
short: S. Albers, M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1164–1188.
conference:
end_date: 1997-05-06
location: El Paso, TX, United States
name: 'STOC97: 29th Annual Symposium on Theory of Computing'
start_date: 1997-05-04
date_created: 2022-07-29T09:04:36Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-02-17T14:41:36Z
day: '01'
doi: 10.1137/s009753979732428x
extern: '1'
intvolume: ' 29'
issue: '4'
keyword:
- directed graph
- exploration algorithm
language:
- iso: eng
month: '07'
oa_version: None
page: 1164-1188
publication: SIAM Journal on Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring unknown environments
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '11770'
abstract:
- lang: eng
text: 'We compare several algorithms for identifying mirrored hosts on the World
Wide Web. The algorithms operate on the basis of URL strings and linkage data:
the type of information about Web pages easily available from Web proxies and
crawlers. Identification of mirrored hosts can improve Web-based information retrieval
in several ways: first, by identifying mirrored hosts, search engines can avoid
storing and returning duplicate documents. Second, several new information retrieval
techniques for the Web make inferences based on the explicit links among hypertext
documents—mirroring perturbs their graph model and degrades performance. Third,
mirroring information can be used to redirect users to alternate mirror sites
to compensate for various failures, and can thus improve the performance of Web
browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting
mirrored host pairs (that is, algorithms that are based on page attributes such
as URL, IP address, and hyperlinks between pages, and not on the page content)
on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity
information. Our best approach is one which combines five algorithms and achieved
a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.'
article_processing_charge: No
article_type: original
author:
- first_name: Krishna
full_name: Bharat, Krishna
last_name: Bharat
- first_name: Andrei
full_name: Broder, Andrei
last_name: Broder
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find
mirrored hosts on the WWW. Journal of the American Society for Information
Science. 2000;51(12):1114-1122. doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
apa: Bharat, K., Broder, A., Dean, J., & Henzinger, M. H. (2000). A comparison
of techniques to find mirrored hosts on the WWW. Journal of the American Society
for Information Science. Wiley. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
chicago: Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A
Comparison of Techniques to Find Mirrored Hosts on the WWW.” Journal of the
American Society for Information Science. Wiley, 2000. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
ieee: K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques
to find mirrored hosts on the WWW,” Journal of the American Society for Information
Science, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.
ista: Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques
to find mirrored hosts on the WWW. Journal of the American Society for Information
Science. 51(12), 1114–1122.
mla: Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts
on the WWW.” Journal of the American Society for Information Science, vol.
51, no. 12, Wiley, 2000, pp. 1114–22, doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
short: K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society
for Information Science 51 (2000) 1114–1122.
date_created: 2022-08-08T12:57:37Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-02-10T08:27:19Z
day: '01'
doi: 10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
extern: '1'
intvolume: ' 51'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
month: '10'
oa: 1
oa_version: Published Version
page: 1114-1122
publication: Journal of the American Society for Information Science
publication_identifier:
issn:
- 0002-8231
- 1097-4571
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of techniques to find mirrored hosts on the WWW
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2000'
...
---
_id: '11802'
abstract:
- lang: eng
text: In this paper we survey algorithmic aspects of Web information retrieval.
As an example, we discuss ranking of search engine results using connectivity
analysis.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Web information retrieval - an algorithmic perspective. In:
8th Annual European Symposium on Algorithms. Vol 1879. Springer Nature;
2000:1–8. doi:10.1007/3-540-45253-2_1'
apa: 'Henzinger, M. H. (2000). Web information retrieval - an algorithmic perspective.
In 8th Annual European Symposium on Algorithms (Vol. 1879, pp. 1–8). Saarbrücken,
Germany: Springer Nature. https://doi.org/10.1007/3-540-45253-2_1'
chicago: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
In 8th Annual European Symposium on Algorithms, 1879:1–8. Springer Nature,
2000. https://doi.org/10.1007/3-540-45253-2_1.
ieee: M. H. Henzinger, “Web information retrieval - an algorithmic perspective,”
in 8th Annual European Symposium on Algorithms, Saarbrücken, Germany, 2000,
vol. 1879, pp. 1–8.
ista: 'Henzinger MH. 2000. Web information retrieval - an algorithmic perspective.
8th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms,
LNCS, vol. 1879, 1–8.'
mla: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
8th Annual European Symposium on Algorithms, vol. 1879, Springer Nature,
2000, pp. 1–8, doi:10.1007/3-540-45253-2_1.
short: M.H. Henzinger, in:, 8th Annual European Symposium on Algorithms, Springer
Nature, 2000, pp. 1–8.
conference:
end_date: 2000-09-08
location: Saarbrücken, Germany
name: 'ESA: European Symposium on Algorithms'
start_date: 2000-09-05
date_created: 2022-08-11T13:25:07Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-02-13T12:08:21Z
day: '01'
doi: 10.1007/3-540-45253-2_1
extern: '1'
intvolume: ' 1879'
language:
- iso: eng
month: '09'
oa_version: None
page: 1–8
publication: 8th Annual European Symposium on Algorithms
publication_identifier:
eisbn:
- '9783540452539'
eissn:
- 1611-3349
isbn:
- '9783540410041'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Web information retrieval - an algorithmic perspective
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1879
year: '2000'
...
---
_id: '11893'
abstract:
- lang: eng
text: "We present fully dynamic algorithms for maintaining the biconnected components
in general and plane graphs.\r\n\r\nA fully dynamic algorithm maintains a graph
during a sequence of insertions and deletions of edges or isolated vertices. Let
m be the number of edges and n be the number of vertices in a graph. The time
per operation of the best deterministic algorithms is \U0001D442(\U0001D45B√)
in general graphs and O(log n) in plane graphs for fully dynamic connectivity
and O(min m2/3 ,n}) in general graphs and \U0001D442(\U0001D45B√) in plane graphs
for fully dynamic biconnectivity. We improve the later running times to \U0001D442(\U0001D45Alog\U0001D45B‾‾‾‾‾‾‾√)
in general graphs and O(log 2n ) in plane graphs. Our algorithm for general graphscan
also find the biconnected components of all vertices in time O(n)."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. Improved data structures for fully dynamic biconnectivity. SIAM
Journal on Computing. 2000;29(6):1761-1815. doi:10.1137/s0097539794263907
apa: Henzinger, M. H. (2000). Improved data structures for fully dynamic biconnectivity.
SIAM Journal on Computing. Society for Industrial & Applied Mathematics.
https://doi.org/10.1137/s0097539794263907
chicago: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
SIAM Journal on Computing. Society for Industrial & Applied Mathematics,
2000. https://doi.org/10.1137/s0097539794263907.
ieee: M. H. Henzinger, “Improved data structures for fully dynamic biconnectivity,”
SIAM Journal on Computing, vol. 29, no. 6. Society for Industrial &
Applied Mathematics, pp. 1761–1815, 2000.
ista: Henzinger MH. 2000. Improved data structures for fully dynamic biconnectivity.
SIAM Journal on Computing. 29(6), 1761–1815.
mla: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
SIAM Journal on Computing, vol. 29, no. 6, Society for Industrial &
Applied Mathematics, 2000, pp. 1761–815, doi:10.1137/s0097539794263907.
short: M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1761–1815.
date_created: 2022-08-17T08:45:41Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-02-17T14:39:47Z
day: '01'
doi: 10.1137/s0097539794263907
extern: '1'
intvolume: ' 29'
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 1761-1815
publication: SIAM Journal on Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved data structures for fully dynamic biconnectivity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '2325'
alternative_title:
- Contemporary Mathematics
author:
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Seiringer R. Inequalities for Schrödinger operators and applications to the
stability of matter problem . In: Vol 529. American Mathematical Society; 2000:53-72.
doi:10.1090/conm/529'
apa: Seiringer, R. (2000). Inequalities for Schrödinger operators and applications
to the stability of matter problem (Vol. 529, pp. 53–72). Presented at the Arizona
School of Analysis With Applications, American Mathematical Society. https://doi.org/10.1090/conm/529
chicago: Seiringer, Robert. “Inequalities for Schrödinger Operators and Applications
to the Stability of Matter Problem ,” 529:53–72. American Mathematical Society,
2000. https://doi.org/10.1090/conm/529.
ieee: R. Seiringer, “Inequalities for Schrödinger operators and applications to
the stability of matter problem ,” presented at the Arizona School of Analysis
With Applications, 2000, vol. 529, pp. 53–72.
ista: Seiringer R. 2000. Inequalities for Schrödinger operators and applications
to the stability of matter problem . Arizona School of Analysis With Applications,
Contemporary Mathematics, vol. 529, 53–72.
mla: Seiringer, Robert. Inequalities for Schrödinger Operators and Applications
to the Stability of Matter Problem . Vol. 529, American Mathematical Society,
2000, pp. 53–72, doi:10.1090/conm/529.
short: R. Seiringer, in:, American Mathematical Society, 2000, pp. 53–72.
conference:
name: Arizona School of Analysis With Applications
date_created: 2018-12-11T11:57:00Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:47Z
day: '01'
doi: 10.1090/conm/529
extern: 1
intvolume: ' 529'
month: '01'
page: 53 - 72
publication_status: published
publisher: American Mathematical Society
publist_id: '4602'
quality_controlled: 0
status: public
title: 'Inequalities for Schrödinger operators and applications to the stability of
matter problem '
type: conference
volume: 529
year: '2000'
...
---
_id: '2343'
abstract:
- lang: eng
text: We study the energy levels of a single particle in a homogeneous magnetic
field and in an axially symmetric external potential. For potentials that are
superharmonic off the central axis, we find a general 'pseudoconcave' ordering
of the ground state energies of the Hamiltonian restricted to the sectors with
fixed angular momentum. The physical applications include atoms and ions in strong
magnetic fields. There the energies are monotone increasing and concave in angular
momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends
to the entire lowest band of Bloch functions.
author:
- first_name: Bernhard
full_name: Baumgartner, Bernhard
last_name: Baumgartner
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous
magnetic fields. Letters in Mathematical Physics. 2000;54(3):213-226. doi: 10.1023/A:1010978807635
apa: Baumgartner, B., & Seiringer, R. (2000). On the ordering of energy levels
in homogeneous magnetic fields. Letters in Mathematical Physics. Springer.
https://doi.org/ 10.1023/A:1010978807635
chicago: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy
Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics.
Springer, 2000. https://doi.org/
10.1023/A:1010978807635.
ieee: B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous
magnetic fields,” Letters in Mathematical Physics, vol. 54, no. 3. Springer,
pp. 213–226, 2000.
ista: Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous
magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.
mla: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels
in Homogeneous Magnetic Fields.” Letters in Mathematical Physics, vol.
54, no. 3, Springer, 2000, pp. 213–26, doi:
10.1023/A:1010978807635.
short: B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.
date_created: 2018-12-11T11:57:06Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2021-01-12T06:56:54Z
day: '01'
doi: ' 10.1023/A:1010978807635'
extern: 1
intvolume: ' 54'
issue: '3'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0011031
month: '11'
oa: 1
page: 213 - 226
publication: Letters in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4582'
quality_controlled: 0
status: public
title: On the ordering of energy levels in homogeneous magnetic fields
type: journal_article
volume: 54
year: '2000'
...
---
_id: '8525'
abstract:
- lang: eng
text: Let M be a smooth compact manifold of dimension at least 2 and Diffr(M) be
the space of C r smooth diffeomorphisms of M. Associate to each diffeomorphism
f;isin; Diffr(M) the sequence P n (f) of the number of isolated periodic points
for f of period n. In this paper we exhibit an open set N in the space of diffeomorphisms
Diffr(M) such for a Baire generic diffeomorphism f∈N the number of periodic points
P n f grows with a period n faster than any following sequence of numbers {a n
} n ∈ Z + along a subsequence, i.e. P n (f)>a ni for some n i →∞ with i→∞. In
the cases of surface diffeomorphisms, i.e. dim M≡2, an open set N with a supergrowth
of the number of periodic points is a Newhouse domain. A proof of the man result
is based on the Gontchenko–Shilnikov–Turaev Theorem [GST]. A complete proof of
that theorem is also presented.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. Generic diffeomorphisms with superexponential growth of number
of periodic orbits. Communications in Mathematical Physics. 2000;211:253-271.
doi:10.1007/s002200050811
apa: Kaloshin, V. (2000). Generic diffeomorphisms with superexponential growth of
number of periodic orbits. Communications in Mathematical Physics. Springer
Nature. https://doi.org/10.1007/s002200050811
chicago: Kaloshin, Vadim. “Generic Diffeomorphisms with Superexponential Growth
of Number of Periodic Orbits.” Communications in Mathematical Physics.
Springer Nature, 2000. https://doi.org/10.1007/s002200050811.
ieee: V. Kaloshin, “Generic diffeomorphisms with superexponential growth of number
of periodic orbits,” Communications in Mathematical Physics, vol. 211.
Springer Nature, pp. 253–271, 2000.
ista: Kaloshin V. 2000. Generic diffeomorphisms with superexponential growth of
number of periodic orbits. Communications in Mathematical Physics. 211, 253–271.
mla: Kaloshin, Vadim. “Generic Diffeomorphisms with Superexponential Growth of Number
of Periodic Orbits.” Communications in Mathematical Physics, vol. 211,
Springer Nature, 2000, pp. 253–71, doi:10.1007/s002200050811.
short: V. Kaloshin, Communications in Mathematical Physics 211 (2000) 253–271.
date_created: 2020-09-18T10:50:20Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2021-01-12T08:19:52Z
day: '01'
doi: 10.1007/s002200050811
extern: '1'
intvolume: ' 211'
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '04'
oa_version: None
page: 253-271
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
- 1432-0916
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Generic diffeomorphisms with superexponential growth of number of periodic
orbits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 211
year: '2000'
...
---
_id: '4637'
abstract:
- lang: eng
text: "In the synchronous composition of processes, one process may prevent another
process from proceeding unless compositions without a well-defined product behavior
are ruled out. They can be ruled out semantically, by insisting on the existence
of certain fixed points, or syntactically, by equipping processes with types,
which make the dependencies between input and output signals transparent. We classify
various typing mechanisms and study their effects on the control problem.\r\nA
static type enforces fixed, acyclic dependencies between input and output ports.
For example, synchronous hardware without combinational loops can be typed statically.
A dynamic type may vary the dependencies from state to state, while maintaining
acyclicity, as in level-sensitive latches. Then, two dynamically typed processes
can be syntactically compatible, if all pairs of possible dependencies are compatible,
or semantically compatible, if in each state the combined dependencies remain
acyclic. For a given plant process and control objective, there may be a controller
of a static type, or only a controller of a syntactically compatible dynamic type,
or only a controller of a semantically compatible dynamic type. We show this to
be a strict hierarchy of possibilities, and we present algorithms and determine
the complexity of the corresponding control problems.\r\nFurthermore, we consider
versions of the control problem in which the type of the controller (static or
dynamic) is given. We show that the solution of these fixed-type control problems
requires the evaluation of partially ordered (Henkin) quantifiers on boolean formulas,
and is therefore harder (nondeterministic exponential time) than more traditional
control questions"
acknowledgement: This research was supported in part by the DARPA grants NAG2-1214
and F33615-C-98-3614, the SRC contract 99-TJ-683.003, the MARCO grant 98-DT-660,
and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
citation:
ama: 'De Alfaro L, Henzinger TA, Mang F. The control of synchronous systems. In:
Proceedings of the 11th International Conference on Concurrency Theory.
Vol 1877. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2000:458-473. doi:10.1007/3-540-44618-4_33'
apa: 'De Alfaro, L., Henzinger, T. A., & Mang, F. (2000). The control of synchronous
systems. In Proceedings of the 11th International Conference on Concurrency
Theory (Vol. 1877, pp. 458–473). University Park, PA, USA: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-44618-4_33'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Freddy Mang. “The Control of Synchronous
Systems.” In Proceedings of the 11th International Conference on Concurrency
Theory, 1877:458–73. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2000.
https://doi.org/10.1007/3-540-44618-4_33.
ieee: L. De Alfaro, T. A. Henzinger, and F. Mang, “The control of synchronous systems,”
in Proceedings of the 11th International Conference on Concurrency Theory,
University Park, PA, USA, 2000, vol. 1877, pp. 458–473.
ista: 'De Alfaro L, Henzinger TA, Mang F. 2000. The control of synchronous systems.
Proceedings of the 11th International Conference on Concurrency Theory. CONCUR:
Concurrency Theory, LNCS, vol. 1877, 458–473.'
mla: De Alfaro, Luca, et al. “The Control of Synchronous Systems.” Proceedings
of the 11th International Conference on Concurrency Theory, vol. 1877, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2000, pp. 458–73, doi:10.1007/3-540-44618-4_33.
short: L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 11th International
Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2000, pp. 458–473.
conference:
end_date: 2000-08-25
location: University Park, PA, USA
name: 'CONCUR: Concurrency Theory'
start_date: 2000-08-22
date_created: 2018-12-11T12:09:53Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-13T11:00:46Z
day: '01'
doi: 10.1007/3-540-44618-4_33
extern: '1'
intvolume: ' 1877'
language:
- iso: eng
month: '01'
oa_version: None
page: 458 - 473
publication: Proceedings of the 11th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540678977'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '69'
quality_controlled: '1'
status: public
title: The control of synchronous systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1877
year: '2000'
...
---
_id: '4638'
abstract:
- lang: eng
text: "Any formal method or tool is almost certainly more often applied in situations
where the outcome is failure (a counterexample) rather than success (a correctness
proof). We present a method for symbolic model checking that can lead to significant
time and memory savings for model-checking runs that fail, while occurring only
a small overhead for model-checking runs that succeed. Our method discovers an
error as soon as it cannot be prevented, which can be long before it actually
occurs; for example, the violation of an invariant may become unpreventable many
transitions before the invariant is violated.\r\nThe key observation is that “unpreventability”
is a local property of a single module: an error is unpreventable in a module
state if no environment can prevent it. Therefore, unpreventability is inexpensive
to compute for each module, yet can save much work in the state exploration of
the global, compound system. Based on different degrees of information available
about the environment, we define and implement several notions of “unpreventability,”
including the standard notion of uncontrollability from discrete-event control.
We present experimental results for two examples, a distributed database protocol
and a wireless communication protocol."
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the SRC contract 99-TJ-683.003, the MARCO grant 98-DT-660, the DARPA (MARCO) grant
MDA972-99-1-0001, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
citation:
ama: 'De Alfaro L, Henzinger TA, Mang F. Detecting errors before reaching them.
In: Proceedings of the 12th International Conference on Computer Aided Verification.
Vol 1855. Springer; 2000:186-201. doi:10.1007/10722167_17'
apa: 'De Alfaro, L., Henzinger, T. A., & Mang, F. (2000). Detecting errors before
reaching them. In Proceedings of the 12th International Conference on Computer
Aided Verification (Vol. 1855, pp. 186–201). Chicago, IL, USA: Springer. https://doi.org/10.1007/10722167_17'
chicago: De Alfaro, Luca, Thomas A Henzinger, and Freddy Mang. “Detecting Errors
before Reaching Them.” In Proceedings of the 12th International Conference
on Computer Aided Verification, 1855:186–201. Springer, 2000. https://doi.org/10.1007/10722167_17.
ieee: L. De Alfaro, T. A. Henzinger, and F. Mang, “Detecting errors before reaching
them,” in Proceedings of the 12th International Conference on Computer Aided
Verification, Chicago, IL, USA, 2000, vol. 1855, pp. 186–201.
ista: 'De Alfaro L, Henzinger TA, Mang F. 2000. Detecting errors before reaching
them. Proceedings of the 12th International Conference on Computer Aided Verification.
CAV: Computer-Aided Verification, LNCS, vol. 1855, 186–201.'
mla: De Alfaro, Luca, et al. “Detecting Errors before Reaching Them.” Proceedings
of the 12th International Conference on Computer Aided Verification, vol.
1855, Springer, 2000, pp. 186–201, doi:10.1007/10722167_17.
short: L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 12th International
Conference on Computer Aided Verification, Springer, 2000, pp. 186–201.
conference:
end_date: 2000-07-19
location: Chicago, IL, USA
name: 'CAV: Computer-Aided Verification'
start_date: 2000-07-15
date_created: 2018-12-11T12:09:53Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-13T13:18:06Z
day: '01'
doi: 10.1007/10722167_17
extern: '1'
intvolume: ' 1855'
language:
- iso: eng
month: '01'
oa_version: None
page: 186 - 201
publication: Proceedings of the 12th International Conference on Computer Aided Verification
publication_identifier:
isbn:
- '9783540677703'
publication_status: published
publisher: Springer
publist_id: '70'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Detecting errors before reaching them
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1855
year: '2000'
...
---
_id: '4627'
abstract:
- lang: eng
text: 'We consider two-player games, which are played on a finite state space for
an infinite number of rounds. The games are concurrent, that is, in each round,
the two players choose their moves independently and simultaneously; the current
state and the two moves determine a successor state. We consider omega-regular
winning conditions on the resulting infinite state sequence. To model the independent
choice of moves, both players are allowed to use randomization for selecting their
moves. This gives rise to the following qualitative modes of winning, which can
be studied without numerical considerations concerning probabilities: sure-win
(player 1 can ensure winning with certainty), almost-sure-win (player 1 can ensure
winning with probability 1), limit-win (player 1 can ensure winning with probability
arbitrarily close to 1), bounded-win (player 1 can ensure winning with probability
bounded away from 0), positive-win (player 1 can ensure winning with positive
probability), and exist-win (player 1 can ensure that at least one possible outcome
of the game satisfies the winning condition).We provide algorithms for computing
the sets of winning states for each of these winning modes. In particular, we
solve concurrent Rabin-chain games in n0 (m) time, where n is the size of the
game structure and m is the number of pairs in the Rabin-chain condition. While
this complexity is in line with traditional turn-based games, where in each state
only one of the two players has a choice of moves, our algorithms are considerably
more involved than those for turn-based games are. This is because concurrent
games violate two of the most fundamental properties of turn-based games. First,
concurrent games are not determined, but rather exhibit a more general duality
property, which involves multiple modes of winning. Second, winning strategies
for concurrent games may require infinite memory.'
article_processing_charge: No
author:
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'De Alfaro L, Henzinger TA. Concurrent omega-regular games. In: Proceedings
of the 15th Annual IEEE Symposium on Logic in Computer Science. IEEE; 2000:141-154.
doi:10.1109/LICS.2000.855763'
apa: 'De Alfaro, L., & Henzinger, T. A. (2000). Concurrent omega-regular games.
In Proceedings of the 15th Annual IEEE Symposium on Logic in Computer Science
(pp. 141–154). Santa Barbara, CA, USA: IEEE. https://doi.org/10.1109/LICS.2000.855763'
chicago: De Alfaro, Luca, and Thomas A Henzinger. “Concurrent Omega-Regular Games.”
In Proceedings of the 15th Annual IEEE Symposium on Logic in Computer Science,
141–54. IEEE, 2000. https://doi.org/10.1109/LICS.2000.855763.
ieee: L. De Alfaro and T. A. Henzinger, “Concurrent omega-regular games,” in Proceedings
of the 15th Annual IEEE Symposium on Logic in Computer Science, Santa Barbara,
CA, USA, 2000, pp. 141–154.
ista: 'De Alfaro L, Henzinger TA. 2000. Concurrent omega-regular games. Proceedings
of the 15th Annual IEEE Symposium on Logic in Computer Science. LICS: Logic in
Computer Science, 141–154.'
mla: De Alfaro, Luca, and Thomas A. Henzinger. “Concurrent Omega-Regular Games.”
Proceedings of the 15th Annual IEEE Symposium on Logic in Computer Science,
IEEE, 2000, pp. 141–54, doi:10.1109/LICS.2000.855763.
short: L. De Alfaro, T.A. Henzinger, in:, Proceedings of the 15th Annual IEEE Symposium
on Logic in Computer Science, IEEE, 2000, pp. 141–154.
conference:
end_date: 2000-06-28
location: Santa Barbara, CA, USA
name: 'LICS: Logic in Computer Science'
start_date: 2000-06-26
date_created: 2018-12-11T12:09:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-13T13:24:29Z
day: '01'
doi: 10.1109/LICS.2000.855763
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 141 - 154
publication: Proceedings of the 15th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
isbn:
- '0769507255'
publication_status: published
publisher: IEEE
publist_id: '82'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Concurrent omega-regular games
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '4512'
abstract:
- lang: eng
text: "Masaccio is a formal model for hybrid dynamical systems which are built from
atomic discrete components (difference equations) and atomic continuous components
(differential equations) by parallel and serial composition, arbitrarily nested.
Each system component consists of an interface, which determines the possible
ways of using the component, and a set of executions, which define the possible
behaviors of the component in real time.\r\nVersion 1.0 (May 2000).\r\n"
acknowledgement: This research was supported in part by the DARPA grants NAG2-1214
and F33615-C-98-3614, and by the MARCO grant 98-DT-660.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Henzinger TA. Masaccio: A formal model for embedded components. In: Proceedings
of the 1st International Conference on Theoretical Computer Science . Vol
1872. Springer; 2000:549-563. doi:10.1007/3-540-44929-9_38'
apa: 'Henzinger, T. A. (2000). Masaccio: A formal model for embedded components.
In Proceedings of the 1st International Conference on Theoretical Computer
Science (Vol. 1872, pp. 549–563). Sendai, Japan: Springer. https://doi.org/10.1007/3-540-44929-9_38'
chicago: 'Henzinger, Thomas A. “Masaccio: A Formal Model for Embedded Components.”
In Proceedings of the 1st International Conference on Theoretical Computer
Science , 1872:549–63. Springer, 2000. https://doi.org/10.1007/3-540-44929-9_38.'
ieee: 'T. A. Henzinger, “Masaccio: A formal model for embedded components,” in Proceedings
of the 1st International Conference on Theoretical Computer Science , Sendai,
Japan, 2000, vol. 1872, pp. 549–563.'
ista: 'Henzinger TA. 2000. Masaccio: A formal model for embedded components. Proceedings
of the 1st International Conference on Theoretical Computer Science . TCS: Theoretical
Computer Science, LNCS, vol. 1872, 549–563.'
mla: 'Henzinger, Thomas A. “Masaccio: A Formal Model for Embedded Components.” Proceedings
of the 1st International Conference on Theoretical Computer Science , vol.
1872, Springer, 2000, pp. 549–63, doi:10.1007/3-540-44929-9_38.'
short: T.A. Henzinger, in:, Proceedings of the 1st International Conference on Theoretical
Computer Science , Springer, 2000, pp. 549–563.
conference:
end_date: 2000-08-19
location: Sendai, Japan
name: 'TCS: Theoretical Computer Science'
start_date: 2000-08-17
date_created: 2018-12-11T12:09:14Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-13T13:48:08Z
day: '01'
doi: 10.1007/3-540-44929-9_38
extern: '1'
intvolume: ' 1872'
language:
- iso: eng
month: '01'
oa_version: None
page: 549 - 563
publication: 'Proceedings of the 1st International Conference on Theoretical Computer
Science '
publication_identifier:
isbn:
- '9783540678236'
publication_status: published
publisher: Springer
publist_id: '215'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Masaccio: A formal model for embedded components'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1872
year: '2000'
...
---
_id: '4598'
abstract:
- lang: eng
text: A hybrid system is a dynamical system with both discrete and continuous state
changes. For analysis purposes, it is often useful to abstract a system in a way
that preserves the properties being analyzed while hiding the details that are
of no interest. We show that interesting classes of hybrid systems can be abstracted
to purely discrete systems while preserving all properties that are definable
in temporal logic. The classes that permit discrete abstractions fall into two
categories. Either the continuous dynamics must be restricted, as is the case
for timed and rectangular hybrid systems, or the discrete dynamics must be restricted,
as is the case for o-minimal hybrid systems. In this paper, we survey and unify
results from both areas.
acknowledgement: The authors would like to thank the reviewers for their detailed
comments.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Gerardo
full_name: Lafferriere, Gerardo
last_name: Lafferriere
- first_name: George
full_name: Pappas, George
last_name: Pappas
citation:
ama: Alur R, Henzinger TA, Lafferriere G, Pappas G. Discrete abstractions of hybrid
systems. Proceedings of the IEEE. 2000;88(7):971-984. doi:10.1109/5.871304
apa: Alur, R., Henzinger, T. A., Lafferriere, G., & Pappas, G. (2000). Discrete
abstractions of hybrid systems. Proceedings of the IEEE. IEEE. https://doi.org/10.1109/5.871304
chicago: Alur, Rajeev, Thomas A Henzinger, Gerardo Lafferriere, and George Pappas.
“Discrete Abstractions of Hybrid Systems.” Proceedings of the IEEE. IEEE,
2000. https://doi.org/10.1109/5.871304
.
ieee: R. Alur, T. A. Henzinger, G. Lafferriere, and G. Pappas, “Discrete abstractions
of hybrid systems,” Proceedings of the IEEE, vol. 88, no. 7. IEEE, pp.
971–984, 2000.
ista: Alur R, Henzinger TA, Lafferriere G, Pappas G. 2000. Discrete abstractions
of hybrid systems. Proceedings of the IEEE. 88(7), 971–984.
mla: Alur, Rajeev, et al. “Discrete Abstractions of Hybrid Systems.” Proceedings
of the IEEE, vol. 88, no. 7, IEEE, 2000, pp. 971–84, doi:10.1109/5.871304 .
short: R. Alur, T.A. Henzinger, G. Lafferriere, G. Pappas, Proceedings of the IEEE
88 (2000) 971–984.
date_created: 2018-12-11T12:09:41Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-04-13T13:32:11Z
day: '01'
doi: '10.1109/5.871304 '
extern: '1'
intvolume: ' 88'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 971 - 984
publication: Proceedings of the IEEE
publication_identifier:
issn:
- 0018-9219
publication_status: published
publisher: IEEE
publist_id: '107'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discrete abstractions of hybrid systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 88
year: '2000'
...
---
_id: '4482'
abstract:
- lang: eng
text: "We apply the theory of abstract interpretation to the verification of game
properties for reactive systems. Unlike properties expressed in standard temporal
logics, game properties can distinguish adversarial from collaborative relationships
between the processes of a concurrent program, or the components of a parallel
system. We consider two-player concurrent games –say, component vs. environment–
and specify properties of such games –say, the component has a winning strategy
to obtain a resource, no matter how the environment behaves– in the alternating-time
μ-calculus (Aμ ). A sound abstraction of such a game must at the same time restrict
the behaviors of the component and increase the behaviors of the environment:
if a less powerful component can win against a more powerful environment, then
surely the original component can win against the original environment.\r\nWe
formalize the concrete semantics of a concurrent game in terms of controllable
and uncontrollable predecessor predicates, which suffice for model checking all
Aμ properties by applying boolean operations and iteration. We then define the
abstract semantics of a concurrent game in terms of abstractions for the controllable
and uncontrollable predecessor predicates. This allows us to give general characterizations
for the soundness and completeness of abstract games with respect to Aμ properties.
We also present a simple programming language for multi-process programs, and
show how approximations of the maximal abstraction (w.r.t. Aμ properties) can
be obtained from the program text. We apply the theory to two practical verification
examples, a communication protocol developed at the Berkeley Wireless Research
Center, and a protocol converter. In the wireless protocol, both the use of a
game property for specification and the use of abstraction for automatic verification
were instrumental to uncover a subtle bug."
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the MARCO grant 98-DT-660,
the ARO MURI grant DAAH-04-96-1-0341, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
- first_name: Jean
full_name: Raskin, Jean
last_name: Raskin
citation:
ama: 'Henzinger TA, Majumdar R, Mang F, Raskin J. Abstract interpretation of game
properties. In: Proceedings of the 7th International Symposium on Static Analysis.
Vol 1824. Springer; 2000:220-239. doi:10.1007/978-3-540-45099-3_12'
apa: 'Henzinger, T. A., Majumdar, R., Mang, F., & Raskin, J. (2000). Abstract
interpretation of game properties. In Proceedings of the 7th International
Symposium on Static Analysis (Vol. 1824, pp. 220–239). Santa Barbara, CA,
USA: Springer. https://doi.org/10.1007/978-3-540-45099-3_12'
chicago: Henzinger, Thomas A, Ritankar Majumdar, Freddy Mang, and Jean Raskin. “Abstract
Interpretation of Game Properties.” In Proceedings of the 7th International
Symposium on Static Analysis, 1824:220–39. Springer, 2000. https://doi.org/10.1007/978-3-540-45099-3_12.
ieee: T. A. Henzinger, R. Majumdar, F. Mang, and J. Raskin, “Abstract interpretation
of game properties,” in Proceedings of the 7th International Symposium on Static
Analysis, Santa Barbara, CA, USA, 2000, vol. 1824, pp. 220–239.
ista: 'Henzinger TA, Majumdar R, Mang F, Raskin J. 2000. Abstract interpretation
of game properties. Proceedings of the 7th International Symposium on Static Analysis.
SAS: Static Analysis Symposium, LNCS, vol. 1824, 220–239.'
mla: Henzinger, Thomas A., et al. “Abstract Interpretation of Game Properties.”
Proceedings of the 7th International Symposium on Static Analysis, vol.
1824, Springer, 2000, pp. 220–39, doi:10.1007/978-3-540-45099-3_12.
short: T.A. Henzinger, R. Majumdar, F. Mang, J. Raskin, in:, Proceedings of the
7th International Symposium on Static Analysis, Springer, 2000, pp. 220–239.
conference:
end_date: 2000-07-06
location: Santa Barbara, CA, USA
name: 'SAS: Static Analysis Symposium'
start_date: 2000-06-29
date_created: 2018-12-11T12:09:04Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T12:49:56Z
day: '01'
doi: 10.1007/978-3-540-45099-3_12
extern: '1'
intvolume: ' 1824'
language:
- iso: eng
month: '01'
oa_version: None
page: 220 - 239
publication: Proceedings of the 7th International Symposium on Static Analysis
publication_identifier:
isbn:
- '9783540676683'
publication_status: published
publisher: Springer
publist_id: '248'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Abstract interpretation of game properties
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1824
year: '2000'
...
---
_id: '4481'
abstract:
- lang: eng
text: 'Since hybrid embedded systems are pervasive and often safety-critical, guarantees
about their correct performance are desirable. The hybrid systems model checker
HyTech provides such guarantees and has successfully verified some systems. However,
HyTech severely restricts the continuous dynamics of the system being analyzed
and, therefore, often forces the use of prohibitively expensive discrete and polyhedral
abstractions. We have designed a new algorithm, which is capable of directly verifying
hybrid systems with general continuous dynamics, such as linear and nonlinear
differential equations. The new algorithm conservatively overapproximates the
reachable states of a hybrid automaton by using interval numerical methods. Interval
numerical methods return sets of points that enclose the true result of numerical
computation and, thus, avoid distortions due to the accumulation of round-off
errors. We have implemented the new algorithm in a successor tool to HyTech called
HyperTech. We consider three examples: a thermostat with delay, a two-tank water
system, and an air-traffic collision avoidance protocol. HyperTech enables the
direct, fully automatic analysis of these systems, which is also more accurate
than the use of polyhedral abstractions.'
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the ARO MURI grant DAAH-04-96-1-0341,
and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Benjamin
full_name: Horowitz, Benjamin
last_name: Horowitz
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Horowitz B, Majumdar R, Wong Toi H. Beyond HyTech: Hybrid systems
analysis using interval numerical methods. In: Proceedings of the 3rd International
Workshop on Hybrid Systems. Vol 1790. Springer; 2000:130-144. doi:10.1007/3-540-46430-1_14'
apa: 'Henzinger, T. A., Horowitz, B., Majumdar, R., & Wong Toi, H. (2000). Beyond
HyTech: Hybrid systems analysis using interval numerical methods. In Proceedings
of the 3rd International Workshop on Hybrid Systems (Vol. 1790, pp. 130–144).
Pittsburgh, PA, USA: Springer. https://doi.org/10.1007/3-540-46430-1_14'
chicago: 'Henzinger, Thomas A, Benjamin Horowitz, Ritankar Majumdar, and Howard
Wong Toi. “Beyond HyTech: Hybrid Systems Analysis Using Interval Numerical Methods.”
In Proceedings of the 3rd International Workshop on Hybrid Systems, 1790:130–44.
Springer, 2000. https://doi.org/10.1007/3-540-46430-1_14.'
ieee: 'T. A. Henzinger, B. Horowitz, R. Majumdar, and H. Wong Toi, “Beyond HyTech:
Hybrid systems analysis using interval numerical methods,” in Proceedings of
the 3rd International Workshop on Hybrid Systems, Pittsburgh, PA, USA, 2000,
vol. 1790, pp. 130–144.'
ista: 'Henzinger TA, Horowitz B, Majumdar R, Wong Toi H. 2000. Beyond HyTech: Hybrid
systems analysis using interval numerical methods. Proceedings of the 3rd International
Workshop on Hybrid Systems. HSCC: Hybrid Systems - Computation and Control, LNCS,
vol. 1790, 130–144.'
mla: 'Henzinger, Thomas A., et al. “Beyond HyTech: Hybrid Systems Analysis Using
Interval Numerical Methods.” Proceedings of the 3rd International Workshop
on Hybrid Systems, vol. 1790, Springer, 2000, pp. 130–44, doi:10.1007/3-540-46430-1_14.'
short: T.A. Henzinger, B. Horowitz, R. Majumdar, H. Wong Toi, in:, Proceedings of
the 3rd International Workshop on Hybrid Systems, Springer, 2000, pp. 130–144.
conference:
end_date: 2000-03-25
location: Pittsburgh, PA, USA
name: 'HSCC: Hybrid Systems - Computation and Control'
start_date: 2000-03-23
date_created: 2018-12-11T12:09:04Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T12:44:52Z
day: '01'
doi: 10.1007/3-540-46430-1_14
extern: '1'
intvolume: ' 1790'
language:
- iso: eng
month: '01'
oa_version: None
page: 130 - 144
publication: Proceedings of the 3rd International Workshop on Hybrid Systems
publication_identifier:
isbn:
- '9783540672593'
publication_status: published
publisher: Springer
publist_id: '247'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Beyond HyTech: Hybrid systems analysis using interval numerical methods'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1790
year: '2000'
...
---
_id: '4483'
abstract:
- lang: eng
text: 'Model-checking algorithms can be used to verify, formally and automatically,
if a low-level description of a design conforms with a high-level description.
However, for designs with very large state spaces, prior to the application of
an algorithm, the refinement-checking task needs to be decomposed into subtasks
of manageable complexity. It is natural to decompose the task following the component
structure of the design. However, an individual component often does not satisfy
its requirements unless the component is put into the right context, which constrains
the inputs to the component. Thus, in order to verify each component individually,
we need to make assumptions about its inputs, which are provided by the other
components of the design. This reasoning is circular: component A is verified
under the assumption that context B behaves correctly, and symmetrically, B is
verified assuming the correctness of A. The assume-guarantee paradigm provides
a systematic theory and methodology for ensuring the soundness of the circular
style of postulating and discharging assumptions in component-based reasoning.We
give a tutorial introduction to the assume-guarantee paradigm for decomposing
refinement-checking tasks. To illustrate the method, we step in detail through
the formal verification of a processor pipeline against an instruction set architecture.
In this example, the verification of a three-stage pipeline is broken up into
three subtasks, one for each stage of the pipeline.'
acknowledgement: 'Supported in part by DARPA Information Technology Office, by the
MARC0 Gigascale Silicon Research Center, and by the National Science Foundation. '
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Shaz
full_name: Qadeer, Shaz
last_name: Qadeer
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Henzinger TA, Qadeer S, Rajamani S. Decomposing refinement proofs using assume-guarantee
reasoning. In: Proceedings of the 2000 International Conference on Computer-Aided
Design. IEEE; 2000:245-252. doi:10.1109/ICCAD.2000.896481'
apa: 'Henzinger, T. A., Qadeer, S., & Rajamani, S. (2000). Decomposing refinement
proofs using assume-guarantee reasoning. In Proceedings of the 2000 International
Conference on Computer-Aided Design (pp. 245–252). San Jose, CA, USA: IEEE.
https://doi.org/10.1109/ICCAD.2000.896481'
chicago: Henzinger, Thomas A, Shaz Qadeer, and Sriram Rajamani. “Decomposing Refinement
Proofs Using Assume-Guarantee Reasoning.” In Proceedings of the 2000 International
Conference on Computer-Aided Design, 245–52. IEEE, 2000. https://doi.org/10.1109/ICCAD.2000.896481.
ieee: T. A. Henzinger, S. Qadeer, and S. Rajamani, “Decomposing refinement proofs
using assume-guarantee reasoning,” in Proceedings of the 2000 International
Conference on Computer-Aided Design, San Jose, CA, USA, 2000, pp. 245–252.
ista: 'Henzinger TA, Qadeer S, Rajamani S. 2000. Decomposing refinement proofs using
assume-guarantee reasoning. Proceedings of the 2000 International Conference on
Computer-Aided Design. ICCAD: Computer-Aided Design, 245–252.'
mla: Henzinger, Thomas A., et al. “Decomposing Refinement Proofs Using Assume-Guarantee
Reasoning.” Proceedings of the 2000 International Conference on Computer-Aided
Design, IEEE, 2000, pp. 245–52, doi:10.1109/ICCAD.2000.896481.
short: T.A. Henzinger, S. Qadeer, S. Rajamani, in:, Proceedings of the 2000 International
Conference on Computer-Aided Design, IEEE, 2000, pp. 245–252.
conference:
end_date: 2000-11-09
location: San Jose, CA, USA
name: 'ICCAD: Computer-Aided Design'
start_date: 2000-11-05
date_created: 2018-12-11T12:09:05Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T12:57:52Z
day: '01'
doi: 10.1109/ICCAD.2000.896481
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 245 - 252
publication: Proceedings of the 2000 International Conference on Computer-Aided Design
publication_identifier:
isbn:
- '0780364457'
publication_status: published
publisher: IEEE
publist_id: '249'
quality_controlled: '1'
status: public
title: Decomposing refinement proofs using assume-guarantee reasoning
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '4513'
abstract:
- lang: eng
text: 'A hybrid automaton is a formal model for a mixed discrete-continuous system.
We classify hybrid automata according to what questions about their behavior can
be answered algorithmically. The classification reveals structure on mixed discrete-continuous
state spaces that was previously studied on purely discrete state spaces only.
In particular, various classes of hybrid automata induce finitary trace equivalence
(or similarity, or bisimilarity) relations on an uncountable state space, thus
permitting the application of various model-checking techniques that were originally
developed for finitestate systems. '
acknowledgement: 'This research was supported in part by the Office of Naval Research
Young Investigator award N00014-95-1-0520, by the National Science Foundation CAREER
award CCR-9501708, by the National Science Foundation grant CR9504469, by the Air
Force Office of Scientific Research contract F49620-93-1-0056, by the Army Research
Office MURI grant DAAH-04-96-1-0341, by the Advanced Research Projects Agency grant
NAG2-892, and by the Semiconductor Research Corporation contract 96-DC-324.036. '
alternative_title:
- 'NATO ASI Series F: Computer and Systems Sciences'
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Henzinger TA. The theory of hybrid automata. In: Inan M, Kurshan R, eds. Verification
of Digital and Hybrid Systems. Vol 170. Springer; 2000:265-292. doi:10.1007/978-3-642-59615-5'
apa: Henzinger, T. A. (2000). The theory of hybrid automata. In M. Inan & R.
Kurshan (Eds.), Verification of Digital and Hybrid Systems (Vol. 170, pp.
265–292). Springer. https://doi.org/10.1007/978-3-642-59615-5
chicago: Henzinger, Thomas A. “The Theory of Hybrid Automata.” In Verification
of Digital and Hybrid Systems, edited by M. Inan and Robert Kurshan, 170:265–92.
Springer, 2000. https://doi.org/10.1007/978-3-642-59615-5.
ieee: T. A. Henzinger, “The theory of hybrid automata,” in Verification of Digital
and Hybrid Systems, vol. 170, M. Inan and R. Kurshan, Eds. Springer, 2000,
pp. 265–292.
ista: 'Henzinger TA. 2000.The theory of hybrid automata. In: Verification of Digital
and Hybrid Systems. NATO ASI Series F: Computer and Systems Sciences, vol. 170,
265–292.'
mla: Henzinger, Thomas A. “The Theory of Hybrid Automata.” Verification of Digital
and Hybrid Systems, edited by M. Inan and Robert Kurshan, vol. 170, Springer,
2000, pp. 265–92, doi:10.1007/978-3-642-59615-5.
short: T.A. Henzinger, in:, M. Inan, R. Kurshan (Eds.), Verification of Digital
and Hybrid Systems, Springer, 2000, pp. 265–292.
date_created: 2018-12-11T12:09:14Z
date_published: 2000-04-28T00:00:00Z
date_updated: 2023-04-18T12:37:17Z
day: '28'
doi: 10.1007/978-3-642-59615-5
editor:
- first_name: M.
full_name: Inan, M.
last_name: Inan
- first_name: Robert
full_name: Kurshan, Robert
last_name: Kurshan
extern: '1'
intvolume: ' 170'
language:
- iso: eng
month: '04'
oa_version: None
page: 265 - 292
publication: Verification of Digital and Hybrid Systems
publication_identifier:
isbn:
- '9783642596155'
publication_status: published
publisher: Springer
publist_id: '216'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The theory of hybrid automata
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 170
year: '2000'
...
---
_id: '4433'
abstract:
- lang: eng
text: "Bisimulations enjoy numerous applications in the analysis of labeled transition
systems. Many of these applications are based on two central observations: first,
bisimilar systems satisfy the same branching-time properties; second, bisimilarity
can be checked efficiently for finite-state systems. The local character of bisimulation,
however, makes it difficult to address liveness concerns. Indeed, the definitions
of fair bisimulation that have been proposed in the literature sacrifice locality,
and with it, also efficient checkability. We put forward a new definition of fair
bisimulation which does not suffer from this drawback.\r\nThe bisimilarity of
two systems can be viewed in terms of a game played between a protagonist and
an adversary. In each step of the infinite bisimulation game, the adversary chooses
one system, makes a move, and the protagonist matches it with a move of the other
system. Consistent with this game-based view, we call two fair transition systems
bisimilar if in the bisimulation game, the infinite path produced in the first
system is fair iff the infinite path produced in the second system is fair.\r\nWe
show that this notion of fair bisimulation enjoys the following properties. First,
fairly bisimilar systems satisfy the same formulas of the logics Fair-AFMC (the
fair alternation-free μ-calculus) and Fair-CTL*. Therefore, fair bisimulations
can serve as property-preserving abstractions for these logics and weaker ones,
such as Fair-CTL and LTL. Indeed, Fair-AFMC provides an exact logical characterization
of fair bisimilarity. Second, it can be checked in time polynomial in the number
of states if two systems are fairly bisimilar. This is in stark contrast to all
trace-based equivalences, which are traditionally used for addressing liveness
but require exponential time for checking."
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the SRC contract 99-TJ-683.003, the MARCO grant 98-DT-660, the DARPA (MARCO) grant
MDA972-99-1-0001, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Henzinger TA, Rajamani S. Fair bisimulation. In: Proceedings of the 6th
International Conference on Tools and Algorithms for the Construction and Analysis
of Systems. Vol 1785. Springer; 2000:299-314. doi:10.1007/3-540-46419-0_21'
apa: 'Henzinger, T. A., & Rajamani, S. (2000). Fair bisimulation. In Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems (Vol. 1785, pp. 299–314). Berlin, Germany: Springer.
https://doi.org/10.1007/3-540-46419-0_21'
chicago: Henzinger, Thomas A, and Sriram Rajamani. “Fair Bisimulation.” In Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, 1785:299–314. Springer, 2000. https://doi.org/10.1007/3-540-46419-0_21.
ieee: T. A. Henzinger and S. Rajamani, “Fair bisimulation,” in Proceedings of
the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, Berlin, Germany, 2000, vol. 1785, pp. 299–314.
ista: 'Henzinger TA, Rajamani S. 2000. Fair bisimulation. Proceedings of the 6th
International Conference on Tools and Algorithms for the Construction and Analysis
of Systems. TACAS: Tools and Algorithms for the Construction and Analysis of Systems,
LNCS, vol. 1785, 299–314.'
mla: Henzinger, Thomas A., and Sriram Rajamani. “Fair Bisimulation.” Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, vol. 1785, Springer, 2000, pp. 299–314, doi:10.1007/3-540-46419-0_21.
short: T.A. Henzinger, S. Rajamani, in:, Proceedings of the 6th International Conference
on Tools and Algorithms for the Construction and Analysis of Systems, Springer,
2000, pp. 299–314.
conference:
end_date: 2000-04-02
location: Berlin, Germany
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2000-03-25
date_created: 2018-12-11T12:08:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:11:07Z
day: '01'
doi: 10.1007/3-540-46419-0_21
extern: '1'
intvolume: ' 1785'
language:
- iso: eng
month: '01'
oa_version: None
page: 299 - 314
publication: Proceedings of the 6th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems
publication_identifier:
isbn:
- '9783540672821'
publication_status: published
publisher: Springer
publist_id: '297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair bisimulation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1785
year: '2000'
...
---
_id: '4439'
abstract:
- lang: eng
text: "We define five increasingly comprehensive classes of infinite-state systems,
called STS1–5, whose state spaces have finitary structure. For four of these classes,
we provide examples from hybrid systems.\r\nSTS1 These are the systems with finite
bisimilarity quotients. They can be analyzed symbolically by (1) iterating the
predecessor and boolean operations starting from a finite set of observable state
sets, and (2) terminating when no new state sets are generated. This enables model
checking of the μ-calculus.\r\nSTS2 These are the systems with finite similarity
quotients. They can be analyzed symbolically by iterating the predecessor and
positive boolean operations. This enables model checking of the existential and
universal fragments of the μ-calculus.\r\nSTS3 These are the systems with finite
trace-equivalence quotients. They can be analyzed symbolically by iterating the
predecessor operation and a restricted form of positive boolean operations (intersection
is restricted to intersection with observables). This enables model checking of
linear temporal logic.\r\nSTS4 These are the systems with finite distance-equivalence
quotients (two states are equivalent if for every distance d, the same observables
can be reached in d transitions). The systems in this class can be analyzed symbolically
by iterating the predecessor operation and terminating when no new state sets
are generated. This enables model checking of the existential conjunction-free
and universal disjunction-free fragments of the μ-calculus.\r\nSTS5 These are
the systems with finite bounded-reachability quotients (two states are equivalent
if for every distance d, the same observables can be reached in d or fewer transitions).
The systems in this class can be analyzed symbolically by iterating the predecessor
operation and terminating when no new states are encountered. This enables model
checking of reachability properties."
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the MARCO grant 98-DT-660,
the ARO MURI grant DAAH-04-96-1-0341, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
citation:
ama: 'Henzinger TA, Majumdar R. A classification of symbolic transition systems.
In: Proceedings of the 17th Annual Symposium on Theoretical Aspects of Computer
Science. Vol 1770. Springer; 2000:13-34. doi:10.1007/3-540-46541-3_2'
apa: 'Henzinger, T. A., & Majumdar, R. (2000). A classification of symbolic
transition systems. In Proceedings of the 17th Annual Symposium on Theoretical
Aspects of Computer Science (Vol. 1770, pp. 13–34). Lille, France: Springer.
https://doi.org/10.1007/3-540-46541-3_2'
chicago: Henzinger, Thomas A, and Ritankar Majumdar. “A Classification of Symbolic
Transition Systems.” In Proceedings of the 17th Annual Symposium on Theoretical
Aspects of Computer Science, 1770:13–34. Springer, 2000. https://doi.org/10.1007/3-540-46541-3_2.
ieee: T. A. Henzinger and R. Majumdar, “A classification of symbolic transition
systems,” in Proceedings of the 17th Annual Symposium on Theoretical Aspects
of Computer Science, Lille, France, 2000, vol. 1770, pp. 13–34.
ista: 'Henzinger TA, Majumdar R. 2000. A classification of symbolic transition systems.
Proceedings of the 17th Annual Symposium on Theoretical Aspects of Computer Science.
STACS: Theoretical Aspects of Computer Science, LNCS, vol. 1770, 13–34.'
mla: Henzinger, Thomas A., and Ritankar Majumdar. “A Classification of Symbolic
Transition Systems.” Proceedings of the 17th Annual Symposium on Theoretical
Aspects of Computer Science, vol. 1770, Springer, 2000, pp. 13–34, doi:10.1007/3-540-46541-3_2.
short: T.A. Henzinger, R. Majumdar, in:, Proceedings of the 17th Annual Symposium
on Theoretical Aspects of Computer Science, Springer, 2000, pp. 13–34.
conference:
end_date: 2000-02-19
location: Lille, France
name: 'STACS: Theoretical Aspects of Computer Science'
start_date: 2000-02-17
date_created: 2018-12-11T12:08:51Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:02:39Z
day: '01'
doi: 10.1007/3-540-46541-3_2
extern: '1'
intvolume: ' 1770'
language:
- iso: eng
month: '01'
oa_version: None
page: 13 - 34
publication: Proceedings of the 17th Annual Symposium on Theoretical Aspects of Computer
Science
publication_identifier:
isbn:
- '9783540671411'
publication_status: published
publisher: Springer
publist_id: '292'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A classification of symbolic transition systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1770
year: '2000'
...
---
_id: '4435'
abstract:
- lang: eng
text: 'An important case of hybrid systems are the rectangular automata. First,
rectangular dynamics can naturally and arbitrarily closely approximate more general,
nonlinear dynamics. Second, rectangular automata are the most general type of
hybrid systems for which model checking -in particular, Ltl model checking- is
decidable. However, on one hand, the original proofs of decidability did not suggest
practical algorithms and, on the other hand, practical symbolic model-checking
procedures -such as those implemented in HyTech- were not known to terminate on
rectangular automata. We remedy this unsatisfactory situation: we present a symbolic
method for Ltl model checking which can be performed by HyTech and is guaranteed
to terminate on all rectangular automata. We do so by proving that our method
for symbolic Ltl model checking terminates on an infinite-state transition system
if the trace-equivalence relation of the system has finite index, which is the
case for all rectangular automata.'
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the MARCO grant 98-DT-660,
the ARO MURI grant DAAH-04-96-1-0341, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
citation:
ama: 'Henzinger TA, Majumdar R. Symbolic model checking for rectangular hybrid systems.
In: Proceedings of the 6th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems. Vol 1785. Springer; 2000:142-156.
doi:10.1007/3-540-46419-0_11'
apa: 'Henzinger, T. A., & Majumdar, R. (2000). Symbolic model checking for rectangular
hybrid systems. In Proceedings of the 6th International Conference on Tools
and Algorithms for the Construction and Analysis of Systems (Vol. 1785, pp.
142–156). Berlin, Germany: Springer. https://doi.org/10.1007/3-540-46419-0_11'
chicago: Henzinger, Thomas A, and Ritankar Majumdar. “Symbolic Model Checking for
Rectangular Hybrid Systems.” In Proceedings of the 6th International Conference
on Tools and Algorithms for the Construction and Analysis of Systems, 1785:142–56.
Springer, 2000. https://doi.org/10.1007/3-540-46419-0_11.
ieee: T. A. Henzinger and R. Majumdar, “Symbolic model checking for rectangular
hybrid systems,” in Proceedings of the 6th International Conference on Tools
and Algorithms for the Construction and Analysis of Systems, Berlin, Germany,
2000, vol. 1785, pp. 142–156.
ista: 'Henzinger TA, Majumdar R. 2000. Symbolic model checking for rectangular hybrid
systems. Proceedings of the 6th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems. TACAS: Tools and Algorithms for
the Construction and Analysis of Systems, LNCS, vol. 1785, 142–156.'
mla: Henzinger, Thomas A., and Ritankar Majumdar. “Symbolic Model Checking for Rectangular
Hybrid Systems.” Proceedings of the 6th International Conference on Tools and
Algorithms for the Construction and Analysis of Systems, vol. 1785, Springer,
2000, pp. 142–56, doi:10.1007/3-540-46419-0_11.
short: T.A. Henzinger, R. Majumdar, in:, Proceedings of the 6th International Conference
on Tools and Algorithms for the Construction and Analysis of Systems, Springer,
2000, pp. 142–156.
conference:
end_date: 2000-04-02
location: Berlin, Germany
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2000-03-25
date_created: 2018-12-11T12:08:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:08:09Z
day: '01'
doi: 10.1007/3-540-46419-0_11
extern: '1'
intvolume: ' 1785'
language:
- iso: eng
month: '01'
oa_version: None
page: 142 - 156
publication: Proceedings of the 6th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems
publication_identifier:
isbn:
- '9783540672821'
publication_status: published
publisher: Springer
publist_id: '293'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symbolic model checking for rectangular hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1785
year: '2000'
...
---
_id: '4434'
abstract:
- lang: eng
text: 'The algorithmic approach to the analysis of timed and hybrid systems is fundamentally
limited by undecidability, of universality in the timed case (where all continuous
variables are clocks), and of emptiness in the rectangular case (which includes
drifting clocks). Traditional proofs of undecidability encode a single Turing
computation by a single timed trajectory. These proofs have nurtured the hope
that the introduction of “fuzziness” into timed and hybrid models (in the sense
that a system cannot distinguish between trajectories that are sufficiently similar)
may lead to decidability. We show that this is not the case, by sharpening both
fundamental undecidability results. Besides the obvious blow our results deal
to the algorithmic method, they also prove that the standard model of timed and
hybrid systems, while not “robust” in its definition of trajectory acceptance
(which is affected by tiny perturbations in the timing of events), is quite robust
in its mathematical properties: the undecidability barriers are not affected by
reasonable perturbations of the model.'
acknowledgement: 'This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the ARO MURI grant DAAH-04-96-1-0341,
and the NSF CAREER award CCR-9501708. '
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jean
full_name: Raskin, Jean
last_name: Raskin
citation:
ama: 'Henzinger TA, Raskin J. Robust undecidability of timed and hybrid systems.
In: Proceedings of the 3rd International Workshop on Hybrid Systems. Vol
1790. Springer; 2000:145-159. doi:10.1007/3-540-46430-1_15'
apa: 'Henzinger, T. A., & Raskin, J. (2000). Robust undecidability of timed
and hybrid systems. In Proceedings of the 3rd International Workshop on Hybrid
Systems (Vol. 1790, pp. 145–159). Pittsburgh, PA, USA: Springer. https://doi.org/10.1007/3-540-46430-1_15'
chicago: Henzinger, Thomas A, and Jean Raskin. “Robust Undecidability of Timed and
Hybrid Systems.” In Proceedings of the 3rd International Workshop on Hybrid
Systems, 1790:145–59. Springer, 2000. https://doi.org/10.1007/3-540-46430-1_15.
ieee: T. A. Henzinger and J. Raskin, “Robust undecidability of timed and hybrid
systems,” in Proceedings of the 3rd International Workshop on Hybrid Systems,
Pittsburgh, PA, USA, 2000, vol. 1790, pp. 145–159.
ista: 'Henzinger TA, Raskin J. 2000. Robust undecidability of timed and hybrid systems.
Proceedings of the 3rd International Workshop on Hybrid Systems. HSCC: Hybrid
Systems - Computation and Control, LNCS, vol. 1790, 145–159.'
mla: Henzinger, Thomas A., and Jean Raskin. “Robust Undecidability of Timed and
Hybrid Systems.” Proceedings of the 3rd International Workshop on Hybrid Systems,
vol. 1790, Springer, 2000, pp. 145–59, doi:10.1007/3-540-46430-1_15.
short: T.A. Henzinger, J. Raskin, in:, Proceedings of the 3rd International Workshop
on Hybrid Systems, Springer, 2000, pp. 145–159.
conference:
end_date: 2000-03-25
location: Pittsburgh, PA, USA
name: 'HSCC: Hybrid Systems - Computation and Control'
start_date: 2000-03-23
date_created: 2018-12-11T12:08:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:16:13Z
day: '01'
doi: 10.1007/3-540-46430-1_15
extern: '1'
intvolume: ' 1790'
language:
- iso: eng
month: '01'
oa_version: None
page: 145 - 159
publication: Proceedings of the 3rd International Workshop on Hybrid Systems
publication_identifier:
isbn:
- '9783540672593'
publication_status: published
publisher: Springer
publist_id: '298'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Robust undecidability of timed and hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1790
year: '2000'
...
---
_id: '4276'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Population genetics of multiple loci. Genetics Research.
2000;75(3):371-373. doi:10.1017/S0016672300239220
apa: Barton, N. H. (2000). Population genetics of multiple loci. Genetics Research.
Cambridge University Press. https://doi.org/10.1017/S0016672300239220
chicago: Barton, Nicholas H. “Population Genetics of Multiple Loci.” Genetics
Research. Cambridge University Press, 2000. https://doi.org/10.1017/S0016672300239220.
ieee: N. H. Barton, “Population genetics of multiple loci,” Genetics Research,
vol. 75, no. 3. Cambridge University Press, pp. 371–373, 2000.
ista: Barton NH. 2000. Population genetics of multiple loci. Genetics Research.
75(3), 371–373.
mla: Barton, Nicholas H. “Population Genetics of Multiple Loci.” Genetics Research,
vol. 75, no. 3, Cambridge University Press, 2000, pp. 371–73, doi:10.1017/S0016672300239220.
short: N.H. Barton, Genetics Research 75 (2000) 371–373.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-18T15:01:01Z
day: '01'
doi: 10.1017/S0016672300239220
extern: '1'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/population-genetics-of-multiple-loci-by-f-b-christiansen-wiley-series-in-mathematical-and-computational-biology-ed-s-levin-john-wiley-sons-1999-isbn-0-471-979791-365-pages-price-80-hardback/9F9E954479B9FB87B0A07250AD6AAD9C
month: '06'
oa_version: None
page: 371 - 373
publication: Genetics Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1814'
quality_controlled: '1'
status: public
title: Population genetics of multiple loci
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...
---
_id: '4271'
abstract:
- lang: eng
text: "Within hybrid zones that are maintained by a balance between selection and
dispersal, linkage disequilibrium is generated by the mixing of divergent populations.
This linkage disequilibrium causes selection on each locus to act on all other
loci, thereby steepening dines, and generating a barrier to gene flow. Diffusion
models predict simple relations between the strength of linkage disequilibrium
and the dispersal rate, σ, and between the barrier to gene flow, B, and the reduction
in mean fitness, W̄. The aim of this paper is to test the accuracy of these predictions
by comparison with an exact deterministic model of unlinked loci (r = 0.5). Disruptive
selection acts on the proportion of alleles from the parental populations (p,
q): W = exp[-S(4pq)(β)], such that the least fit genotype has fitness e(-S). Where
β << 1, fitness is reduced for a wide range of intermediate genotypes; where
β >> 1, fitness is only reduced for those genotypes close to p = 0.5. Even
with strong epistasis, linkage disequilibria are close to σ2p'(i)p'(j)/r(ij),
where p'(i), p'(j) are the gradients in allele frequency at loci i, j. The barrier
to gene flow, which is reflected in the steepening of neutral dines, is given
by B = ∫(-∞)(∞) (W̄(1/r̄)-1) dx, where r̄, the harmonic mean recombination rate
between the neural and selected loci, is here 0.5. This is a close approximation
for weak selection, but underestimates B for strong selection. The barrier is
stronger for small β, because hybrid fitness is then reduced over a wider range
of p. The widths of the selected dines are harder to predict: though simple approximations
are accurate for β = 1, they become inaccurate for extreme β because, then, fitness
changes sharply with p. Estimates of gene number, made from neutral dines on the
assumption that selection acts against heterozygotes, are accurate for weak selection
when β = 1; however, for strong selection, gene number is overestimated. For β
> 1, gene number is systematically overestimated and, conversely, when β <
1, it is underestimated.\r\n"
acknowledgement: We are grateful to Loeske Kruuk and Michael Turelli for their helpful
comments on the manuscript. N.B. was supported by grants GR3/11635 from the NERC
and GR/L10048 from the EPSRC, and by the Darwin Trust of Edinburgh. M.S. was supported
by a graduate student fellowship from the Yale Institute for Biospheric Studies.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Max
full_name: Shpak, Max
last_name: Shpak
citation:
ama: Barton NH, Shpak M. The effects of epistasis on the structure of hybrid zones.
Genetical Research. 2000;75(2):179-198. doi:10.1017/S0016672399004334
apa: Barton, N. H., & Shpak, M. (2000). The effects of epistasis on the structure
of hybrid zones. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672399004334
chicago: Barton, Nicholas H, and Max Shpak. “The Effects of Epistasis on the Structure
of Hybrid Zones.” Genetical Research. Cambridge University Press, 2000.
https://doi.org/10.1017/S0016672399004334.
ieee: N. H. Barton and M. Shpak, “The effects of epistasis on the structure of hybrid
zones,” Genetical Research, vol. 75, no. 2. Cambridge University Press,
pp. 179–198, 2000.
ista: Barton NH, Shpak M. 2000. The effects of epistasis on the structure of hybrid
zones. Genetical Research. 75(2), 179–198.
mla: Barton, Nicholas H., and Max Shpak. “The Effects of Epistasis on the Structure
of Hybrid Zones.” Genetical Research, vol. 75, no. 2, Cambridge University
Press, 2000, pp. 179–98, doi:10.1017/S0016672399004334.
short: N.H. Barton, M. Shpak, Genetical Research 75 (2000) 179–198.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-04-19T09:58:36Z
day: '01'
doi: 10.1017/S0016672399004334
extern: '1'
external_id:
pmid:
- '10816975'
intvolume: ' 75'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 179 - 198
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1819'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effects of epistasis on the structure of hybrid zones
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...
---
_id: '4274'
abstract:
- lang: eng
text: Selection on one or more genes inevitably perturbs other genes, even when
those genes have no direct effect on fitness. This article reviews the theory
of such genetic hitchhiking, concentrating on effects on neutral loci. Maynard
Smith and Haigh introduced the classical case where the perturbation is due to
a single favourable mutation. This is contrasted with the apparently distinct
effects of inherited variation in fitness due to loosely linked loci. A model
of fluctuating selection is analysed which bridges these alternative treatments.
When alleles sweep between extreme frequencies at a rate λ, the rate of drift
is increased by a factor (1 + E[1/pq]λ/(2(2λ + r))), where the recombination rate
r is much smaller than the strength of selection. In spatially structured populations,
the effects of any one substitution are weaker, and only cause a local increase
in the frequency of a neutral allele. This increase depends primarily on the rate
of recombination relative to selection (r/s), and more weakly, on the neighbourhood
size, Nb = 4πρσ2. Spatial subdivision may allow local selective sweeps to occur
more frequently than is indicated by the overall rate of molecular evolution.
However, it seems unlikely that such sweeps can be sufficiently frequent to increase
significantly the drift of neutral alleles.
acknowledgement: "I am grateful to B. Charlesworth and M.Slatkin for their helpful
comments. This work was supported by the Biotechnology\r\nand Biological Sciences
Research Council, the Natural Environment Research Council, and the Darwin Trust
of Edinburgh."
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London Series B, Biological Sciences. 2000;355(1403):1553-1562.
doi:10.1098/rstb.2000.0716
apa: Barton, N. H. (2000). Genetic hitchhiking. Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences. Royal Society
of London. https://doi.org/10.1098/rstb.2000.0716
chicago: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions
of the Royal Society of London. Series B, Biological Sciences. Royal Society
of London, 2000. https://doi.org/10.1098/rstb.2000.0716.
ieee: N. H. Barton, “Genetic hitchhiking,” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 355, no. 1403.
Royal Society of London, pp. 1553–1562, 2000.
ista: Barton NH. 2000. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London. Series B, Biological Sciences. 355(1403), 1553–1562.
mla: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences, vol. 355, no.
1403, Royal Society of London, 2000, pp. 1553–62, doi:10.1098/rstb.2000.0716.
short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
B, Biological Sciences 355 (2000) 1553–1562.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-11-29T00:00:00Z
date_updated: 2023-04-19T09:35:31Z
day: '29'
doi: 10.1098/rstb.2000.0716
extern: '1'
external_id:
pmid:
- '11127900'
intvolume: ' 355'
issue: '1403'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692896/
month: '11'
oa: 1
oa_version: None
page: 1553 - 1562
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society of London
publist_id: '1815'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic hitchhiking
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 355
year: '2000'
...
---
_id: '4272'
abstract:
- lang: eng
text: 'Analysis of multilocus evolution is usually intractable for more than n ~
10 genes, because the frequencies of very large numbers of genotypes must be followed.
An exact analysis of up to n ~ 100 loci is feasible for a symmetrical model, in
which a set of unlinked loci segregate for two alleles (labeled ''0'' and ''1'')
with interchangeable effects on fitness. All haploid genotypes with the same number
of 1 alleles can then remain equally frequent. However, such a symmetrical solution
may be unstable: for example, under stabilizing selection, populations tend to
fix any one genotype which approaches the optimum. Here, we show how the 2'' x
2'' stability matrix can be decomposed into a set of matrices, each no larger
than n x n. This allows the stability of symmetrical solutions to be determined.
We apply the method to stabilizing and disruptive selection in a single deme and
to selection against heterozygotes in a linear cline. (C) 2000 Academic Press.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Max
full_name: Shpak, Max
last_name: Shpak
citation:
ama: Barton NH, Shpak M. The stability of symmetrical solutions to polygenic models.
Theoretical Population Biology. 2000;57(3):249-263. doi:10.1006/tpbi.2000.1455
apa: Barton, N. H., & Shpak, M. (2000). The stability of symmetrical solutions
to polygenic models. Theoretical Population Biology. Academic Press. https://doi.org/10.1006/tpbi.2000.1455
chicago: Barton, Nicholas H, and Max Shpak. “The Stability of Symmetrical Solutions
to Polygenic Models.” Theoretical Population Biology. Academic Press, 2000.
https://doi.org/10.1006/tpbi.2000.1455.
ieee: N. H. Barton and M. Shpak, “The stability of symmetrical solutions to polygenic
models,” Theoretical Population Biology, vol. 57, no. 3. Academic Press,
pp. 249–263, 2000.
ista: Barton NH, Shpak M. 2000. The stability of symmetrical solutions to polygenic
models. Theoretical Population Biology. 57(3), 249–263.
mla: Barton, Nicholas H., and Max Shpak. “The Stability of Symmetrical Solutions
to Polygenic Models.” Theoretical Population Biology, vol. 57, no. 3, Academic
Press, 2000, pp. 249–63, doi:10.1006/tpbi.2000.1455.
short: N.H. Barton, M. Shpak, Theoretical Population Biology 57 (2000) 249–263.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-05-01T00:00:00Z
date_updated: 2023-04-19T12:36:39Z
day: '01'
doi: 10.1006/tpbi.2000.1455
extern: '1'
external_id:
pmid:
- '10828217'
intvolume: ' 57'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 249 - 263
pmid: 1
publication: Theoretical Population Biology
publication_identifier:
issn:
- 0040-5809
publication_status: published
publisher: Academic Press
publist_id: '1820'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The stability of symmetrical solutions to polygenic models
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '2000'
...
---
_id: '4273'
abstract:
- lang: eng
text: We review the various factors that limit adaptation by natural selection.
Recent discussion of constraints on selection and, conversely, of the factors
that enhance 'evolvability', have concentrated on the kinds of variation that
can be produced. Here, we emphasise that adaptation depends on how the various
evolutionary processes shape variation in populations. We survey the limits that
population genetics places on adaptive evolution, and discuss the relationship
between disparate literatures. BioEssays 22:1075-1084, 2000. (C) 2000 John Wiley
and Sons, Inc.
acknowledgement: We thank Brian Charlesworth, Toby Johnson, and two anonymous referees
for helpful discussions and criticism of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
citation:
ama: Barton NH, Partridge L. Limits to natural selection. BioEssays. 2000;22(12):1075-1084.
doi:10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
apa: Barton, N. H., & Partridge, L. (2000). Limits to natural selection. BioEssays.
Wiley-Blackwell. https://doi.org/10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
chicago: Barton, Nicholas H, and Linda Partridge. “Limits to Natural Selection.”
BioEssays. Wiley-Blackwell, 2000. https://doi.org/10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M.
ieee: N. H. Barton and L. Partridge, “Limits to natural selection,” BioEssays,
vol. 22, no. 12. Wiley-Blackwell, pp. 1075–1084, 2000.
ista: Barton NH, Partridge L. 2000. Limits to natural selection. BioEssays. 22(12),
1075–1084.
mla: Barton, Nicholas H., and Linda Partridge. “Limits to Natural Selection.” BioEssays,
vol. 22, no. 12, Wiley-Blackwell, 2000, pp. 1075–84, doi:10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M.
short: N.H. Barton, L. Partridge, BioEssays 22 (2000) 1075–1084.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-04-19T09:49:52Z
day: '01'
doi: 10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
extern: '1'
external_id:
pmid:
- '11084623'
intvolume: ' 22'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1075 - 1084
pmid: 1
publication: BioEssays
publication_identifier:
issn:
- 0265-9247
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1818'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limits to natural selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2000'
...
---
_id: '4269'
article_processing_charge: No
article_type: original
author:
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: Coyne J, Barton NH, Turelli M. Is Wright’s shifting balance process important
in evolution? Evolution; International Journal of Organic Evolution. 2000;54(1):306-317.
doi:10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
apa: Coyne, J., Barton, N. H., & Turelli, M. (2000). Is Wright’s shifting balance
process important in evolution? Evolution; International Journal of Organic
Evolution. Wiley-Blackwell. https://doi.org/10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
chicago: Coyne, Jerry, Nicholas H Barton, and Michael Turelli. “Is Wright’s Shifting
Balance Process Important in Evolution?” Evolution; International Journal of
Organic Evolution. Wiley-Blackwell, 2000. https://doi.org/10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2.
ieee: J. Coyne, N. H. Barton, and M. Turelli, “Is Wright’s shifting balance process
important in evolution?,” Evolution; International Journal of Organic Evolution,
vol. 54, no. 1. Wiley-Blackwell, pp. 306–317, 2000.
ista: Coyne J, Barton NH, Turelli M. 2000. Is Wright’s shifting balance process
important in evolution? Evolution; International Journal of Organic Evolution.
54(1), 306–317.
mla: Coyne, Jerry, et al. “Is Wright’s Shifting Balance Process Important in Evolution?”
Evolution; International Journal of Organic Evolution, vol. 54, no. 1,
Wiley-Blackwell, 2000, pp. 306–17, doi:10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2.
short: J. Coyne, N.H. Barton, M. Turelli, Evolution; International Journal of Organic
Evolution 54 (2000) 306–317.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-02-01T00:00:00Z
date_updated: 2023-04-19T12:48:29Z
day: '01'
doi: 10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
extern: '1'
external_id:
pmid:
- '10937209'
intvolume: ' 54'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 306 - 317
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1821'
quality_controlled: '1'
status: public
title: Is Wright’s shifting balance process important in evolution?
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 54
year: '2000'
...
---
_id: '4275'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Differentiation. In: Encyclopedia of Biodiversity. Academic
Press; 2000:85-94. doi:10.1016/B0-12-226865-2/00070-5'
apa: Barton, N. H. (2000). Differentiation. In Encyclopedia of Biodiversity
(pp. 85–94). Academic Press. https://doi.org/10.1016/B0-12-226865-2/00070-5
chicago: Barton, Nicholas H. “Differentiation.” In Encyclopedia of Biodiversity,
85–94. Academic Press, 2000. https://doi.org/10.1016/B0-12-226865-2/00070-5.
ieee: N. H. Barton, “Differentiation,” in Encyclopedia of Biodiversity, Academic
Press, 2000, pp. 85–94.
ista: 'Barton NH. 2000.Differentiation. In: Encyclopedia of Biodiversity. , 85–94.'
mla: Barton, Nicholas H. “Differentiation.” Encyclopedia of Biodiversity,
Academic Press, 2000, pp. 85–94, doi:10.1016/B0-12-226865-2/00070-5.
short: N.H. Barton, in:, Encyclopedia of Biodiversity, Academic Press, 2000, pp.
85–94.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-04-19T09:39:55Z
day: '01'
doi: 10.1016/B0-12-226865-2/00070-5
extern: '1'
language:
- iso: eng
month: '10'
oa_version: None
page: 85 - 94
publication: Encyclopedia of Biodiversity
publication_identifier:
isbn:
- '9780122268656'
publication_status: published
publisher: Academic Press
publist_id: '1816'
status: public
title: Differentiation
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '4197'
abstract:
- lang: eng
text: Vertebrate gastrulation involves the specification and coordinated movement
of large populations of cells that give rise to the ectodermal, mesodermal and
endodermal germ layers. Although many of the genes involved in the specification
of cell identity during this process have been identified, little is known of
the genes that coordinate cell movement. Here we show that the zebrafish silberblick
(slb) locus(1) encodes Wnt11 and that Slb/Wnt11 activity is required for cells
to undergo correct convergent extension movements during gastrulation. In the
absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia
and other midline defects in the head(2). The requirement for Slb/Wnt11 is cell
non-autonomous, and our results indicate that the correct extension of axial tissue
is at least partly dependent on medio-lateral cell intercalation in paraxial tissue.
We also show that the slb phenotype is rescued by a truncated form of Dishevelled
that does not signal through the canonical Wnt pathway(3), suggesting that, as
in flies(4), Wnt signalling might mediate morphogenetic events through a divergent
signal transduction cascade. Our results provide genetic and experimental evidence
that Wnt activity in lateral tissues has a crucial role in driving the convergent
extension movements underlying vertebrate gastrulation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Masazumi
full_name: Tada, Masazumi
last_name: Tada
- first_name: Gerd
full_name: Rauch, Gerd
last_name: Rauch
- first_name: Leonor
full_name: Saúde, Leonor
last_name: Saúde
- first_name: Miguel
full_name: Concha, Miguel
last_name: Concha
- first_name: Robert
full_name: Geisler, Robert
last_name: Geisler
- first_name: Derek
full_name: Stemple, Derek
last_name: Stemple
- first_name: James
full_name: Smith, James
last_name: Smith
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
citation:
ama: Heisenberg C-PJ, Tada M, Rauch G, et al. Silberblick/Wnt11 mediates convergent
extension movements during zebrafish gastrulation. Nature. 2000;405(6782):76-81.
doi:10.1038/35011068
apa: Heisenberg, C.-P. J., Tada, M., Rauch, G., Saúde, L., Concha, M., Geisler,
R., … Wilson, S. (2000). Silberblick/Wnt11 mediates convergent extension movements
during zebrafish gastrulation. Nature. Nature Publishing Group. https://doi.org/10.1038/35011068
chicago: Heisenberg, Carl-Philipp J, Masazumi Tada, Gerd Rauch, Leonor Saúde, Miguel
Concha, Robert Geisler, Derek Stemple, James Smith, and Stephen Wilson. “Silberblick/Wnt11
Mediates Convergent Extension Movements during Zebrafish Gastrulation.” Nature.
Nature Publishing Group, 2000. https://doi.org/10.1038/35011068.
ieee: C.-P. J. Heisenberg et al., “Silberblick/Wnt11 mediates convergent
extension movements during zebrafish gastrulation,” Nature, vol. 405, no.
6782. Nature Publishing Group, pp. 76–81, 2000.
ista: Heisenberg C-PJ, Tada M, Rauch G, Saúde L, Concha M, Geisler R, Stemple D,
Smith J, Wilson S. 2000. Silberblick/Wnt11 mediates convergent extension movements
during zebrafish gastrulation. Nature. 405(6782), 76–81.
mla: Heisenberg, Carl-Philipp J., et al. “Silberblick/Wnt11 Mediates Convergent
Extension Movements during Zebrafish Gastrulation.” Nature, vol. 405, no.
6782, Nature Publishing Group, 2000, pp. 76–81, doi:10.1038/35011068.
short: C.-P.J. Heisenberg, M. Tada, G. Rauch, L. Saúde, M. Concha, R. Geisler, D.
Stemple, J. Smith, S. Wilson, Nature 405 (2000) 76–81.
date_created: 2018-12-11T12:07:32Z
date_published: 2000-05-04T00:00:00Z
date_updated: 2023-04-19T14:40:45Z
day: '04'
doi: 10.1038/35011068
extern: '1'
external_id:
pmid:
- '10811221 '
intvolume: ' 405'
issue: '6782'
language:
- iso: eng
month: '05'
oa_version: None
page: 76 - 81
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '1921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Silberblick/Wnt11 mediates convergent extension movements during zebrafish
gastrulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 405
year: '2000'
...
---
_id: '4147'
abstract:
- lang: eng
text: We have developed a protocol to perform a genetic screen for zygotic mutations
affecting embryogenesis on the protochordate Ciona intestinalis. The choice of
this taxon, whose phylogenetic position places it at the basis of the chordates
as one the most primitive vertebrate relatives, could allow to address several
evolutionary questions. The protochordates share many morphological features with
the vertebrates, in primis the presence of a notochord. Ciona intestinalis shows
several ideal features for a mutational analysis, such as external development
and larvae made of a limited number of cells and cell types. Detailed cell lineage
studies are available. The haploid genome size is comparable to the size of the
Drosophila haploid genome. We have optimised conditions for chemical mutagenesis
studying the efficiency at which different concentration of N-ethyl-N-nitrosourea
(ENU) can induce mutations. Because the adult Ciona are hermaphrodites, we are
performing a one-generation screen. The induced mutations are identified by visual
inspection of developmental stages. We report the preliminary results from our
screen including examples of the different classes of mutant phenotypes found
so far.
article_processing_charge: No
article_type: original
author:
- first_name: Paolo
full_name: Sordino, Paolo
last_name: Sordino
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Paola
full_name: Cirino, Paola
last_name: Cirino
- first_name: Alfonso
full_name: Toscano, Alfonso
last_name: Toscano
- first_name: Paola
full_name: Giuliano, Paola
last_name: Giuliano
- first_name: Rita
full_name: Marino, Rita
last_name: Marino
- first_name: Maria
full_name: Pinto, Maria
last_name: Pinto
- first_name: Rosaria
full_name: De Santis, Rosaria
last_name: De Santis
citation:
ama: Sordino P, Heisenberg C-PJ, Cirino P, et al. A mutational approach to the study
of development of the protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia.
2000;85(2):173-176. doi:10.1080/00364827.2000.10414567
apa: Sordino, P., Heisenberg, C.-P. J., Cirino, P., Toscano, A., Giuliano, P., Marino,
R., … De Santis, R. (2000). A mutational approach to the study of development
of the protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia. Taylor
& Francis. https://doi.org/10.1080/00364827.2000.10414567
chicago: Sordino, Paolo, Carl-Philipp J Heisenberg, Paola Cirino, Alfonso Toscano,
Paola Giuliano, Rita Marino, Maria Pinto, and Rosaria De Santis. “A Mutational
Approach to the Study of Development of the Protochordate Ciona Intestinalis (Tunicata,
Chordata).” Sarsia. Taylor & Francis, 2000. https://doi.org/10.1080/00364827.2000.10414567.
ieee: P. Sordino et al., “A mutational approach to the study of development
of the protochordate Ciona intestinalis (Tunicata, Chordata),” Sarsia,
vol. 85, no. 2. Taylor & Francis, pp. 173–176, 2000.
ista: Sordino P, Heisenberg C-PJ, Cirino P, Toscano A, Giuliano P, Marino R, Pinto
M, De Santis R. 2000. A mutational approach to the study of development of the
protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia. 85(2), 173–176.
mla: Sordino, Paolo, et al. “A Mutational Approach to the Study of Development of
the Protochordate Ciona Intestinalis (Tunicata, Chordata).” Sarsia, vol.
85, no. 2, Taylor & Francis, 2000, pp. 173–76, doi:10.1080/00364827.2000.10414567.
short: P. Sordino, C.-P.J. Heisenberg, P. Cirino, A. Toscano, P. Giuliano, R. Marino,
M. Pinto, R. De Santis, Sarsia 85 (2000) 173–176.
date_created: 2018-12-11T12:07:13Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-19T14:50:58Z
day: '01'
doi: 10.1080/00364827.2000.10414567
extern: '1'
intvolume: ' 85'
issue: '2'
language:
- iso: eng
month: '06'
oa_version: None
page: 173 - 176
publication: Sarsia
publication_identifier:
issn:
- 0036-4827
publication_status: published
publisher: Taylor & Francis
publist_id: '1972'
quality_controlled: '1'
status: public
title: A mutational approach to the study of development of the protochordate Ciona
intestinalis (Tunicata, Chordata)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 85
year: '2000'
...
---
_id: '4270'
abstract:
- lang: eng
text: 'A coalescence-based maximum-likelihood method is presented that aims to (i)
detect diversity-reducing events in the recent history of a population and (ii)
distinguish between demographic (e.g., bottlenecks) and selective causes (selective
sweep) of a recent reduction of genetic variability. The former goal is achieved
by taking account of the distortion in the shape of gene genealogies generated
by diversity-reducing events: gene trees tend to be more star-like than under
the standard coalescent. The latter issue is addressed by comparing patterns between
loci: demographic events apply to the whole genome whereas selective events affect
distinct regions of the genome to a varying extent. The maximum-likelihood approach
allows one to estimate the time and strength of diversity-reducing events and
to choose among competing hypotheses. An application to sequence data from an
African population of Drosophila melanogaster shows that the bottleneck hypothesis
is unlikely and that one or several selective sweeps probably occurred in the
recent history of this population.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicolas
full_name: Galtier, Nicolas
last_name: Galtier
- first_name: Frantz
full_name: Depaulis, Frantz
last_name: Depaulis
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Galtier N, Depaulis F, Barton NH. Detecting bottlenecks and selective sweeps
from DNA sequence polymorphism. Genetics. 2000;155(2):981-987. doi:10.1093/genetics/155.2.981
apa: Galtier, N., Depaulis, F., & Barton, N. H. (2000). Detecting bottlenecks
and selective sweeps from DNA sequence polymorphism. Genetics. Genetics
Society of America. https://doi.org/10.1093/genetics/155.2.981
chicago: Galtier, Nicolas, Frantz Depaulis, and Nicholas H Barton. “Detecting Bottlenecks
and Selective Sweeps from DNA Sequence Polymorphism.” Genetics. Genetics
Society of America, 2000. https://doi.org/10.1093/genetics/155.2.981.
ieee: N. Galtier, F. Depaulis, and N. H. Barton, “Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism,” Genetics, vol. 155, no. 2. Genetics
Society of America, pp. 981–987, 2000.
ista: Galtier N, Depaulis F, Barton NH. 2000. Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism. Genetics. 155(2), 981–987.
mla: Galtier, Nicolas, et al. “Detecting Bottlenecks and Selective Sweeps from DNA
Sequence Polymorphism.” Genetics, vol. 155, no. 2, Genetics Society of
America, 2000, pp. 981–87, doi:10.1093/genetics/155.2.981.
short: N. Galtier, F. Depaulis, N.H. Barton, Genetics 155 (2000) 981–987.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-19T14:03:56Z
day: '01'
doi: 10.1093/genetics/155.2.981
extern: '1'
external_id:
pmid:
- '10835415'
intvolume: ' 155'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461106/
month: '06'
oa: 1
oa_version: None
page: 981 - 987
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1822'
status: public
title: Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 155
year: '2000'
...
---
_id: '4268'
article_processing_charge: No
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Partridge L, Barton NH. Evolving evolvability. Nature. 2000;407(6803):457-458.
doi:10.1038/35035173
apa: Partridge, L., & Barton, N. H. (2000). Evolving evolvability. Nature.
Nature Publishing Group. https://doi.org/10.1038/35035173
chicago: Partridge, Linda, and Nicholas H Barton. “Evolving Evolvability.” Nature.
Nature Publishing Group, 2000. https://doi.org/10.1038/35035173.
ieee: L. Partridge and N. H. Barton, “Evolving evolvability,” Nature, vol.
407, no. 6803. Nature Publishing Group, pp. 457–458, 2000.
ista: Partridge L, Barton NH. 2000. Evolving evolvability. Nature. 407(6803), 457–458.
mla: Partridge, Linda, and Nicholas H. Barton. “Evolving Evolvability.” Nature,
vol. 407, no. 6803, Nature Publishing Group, 2000, pp. 457–58, doi:10.1038/35035173.
short: L. Partridge, N.H. Barton, Nature 407 (2000) 457–458.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-04-19T14:37:19Z
day: '01'
doi: 10.1038/35035173
extern: '1'
intvolume: ' 407'
issue: '6803'
language:
- iso: eng
month: '09'
oa_version: None
page: 457 - 458
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '1823'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolving evolvability
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 407
year: '2000'
...
---
_id: '4009'
abstract:
- lang: eng
text: We study the maintenance of a simplicial grid or complex under changing density
requirements. The proposed method works in any fixed dimension and generates grids
by projecting cross-sections of a monotone simplicial complex that lives in one
dimension higher than the grid. The density of the grid is adapted by locally
moving the cross-section up or down along the extra dimension.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Roman
full_name: Waupotitsch, Roman
last_name: Waupotitsch
citation:
ama: Edelsbrunner H, Waupotitsch R. Adaptive simplicial grids from cross-sections
of monotone complexes. International Journal of Computational Geometry and
Applications. 2000;10(3):267-284. doi:10.1142/S0218195900000164
apa: Edelsbrunner, H., & Waupotitsch, R. (2000). Adaptive simplicial grids from
cross-sections of monotone complexes. International Journal of Computational
Geometry and Applications. World Scientific Publishing. https://doi.org/10.1142/S0218195900000164
chicago: Edelsbrunner, Herbert, and Roman Waupotitsch. “Adaptive Simplicial Grids
from Cross-Sections of Monotone Complexes.” International Journal of Computational
Geometry and Applications. World Scientific Publishing, 2000. https://doi.org/10.1142/S0218195900000164.
ieee: H. Edelsbrunner and R. Waupotitsch, “Adaptive simplicial grids from cross-sections
of monotone complexes,” International Journal of Computational Geometry and
Applications, vol. 10, no. 3. World Scientific Publishing, pp. 267–284, 2000.
ista: Edelsbrunner H, Waupotitsch R. 2000. Adaptive simplicial grids from cross-sections
of monotone complexes. International Journal of Computational Geometry and Applications.
10(3), 267–284.
mla: Edelsbrunner, Herbert, and Roman Waupotitsch. “Adaptive Simplicial Grids from
Cross-Sections of Monotone Complexes.” International Journal of Computational
Geometry and Applications, vol. 10, no. 3, World Scientific Publishing, 2000,
pp. 267–84, doi:10.1142/S0218195900000164.
short: H. Edelsbrunner, R. Waupotitsch, International Journal of Computational Geometry
and Applications 10 (2000) 267–284.
date_created: 2018-12-11T12:06:25Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-20T13:45:46Z
day: '01'
doi: 10.1142/S0218195900000164
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 267 - 284
publication: International Journal of Computational Geometry and Applications
publication_identifier:
issn:
- 0218-1959
publication_status: published
publisher: World Scientific Publishing
publist_id: '2117'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adaptive simplicial grids from cross-sections of monotone complexes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2000'
...
---
_id: '4010'
abstract:
- lang: eng
text: A sliver is a tetrahedron whose four vertices lie close to a plane and whose
orthogonal projection to that plane is a convex quadrilateral with no short edge.
Slivers are notoriously common in 3-dimensional Delaunay triangulations even for
well-spaced point sets. We show that, if the Delaunay triangulation has the ratio
property introduced in Miller et al. [1995], then there is an assignment of weights
so the weighted Delaunay triangulation contains no slivers. We also give an algorithm
to compute such a weight assignment.
acknowledgement: NSF under grant DMS 98-73945, NSF under grant CCR 96-19542 and ARO
under grant DAAG-55-98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Siu
full_name: Cheng, Siu
last_name: Cheng
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Facello, Michael
last_name: Facello
- first_name: Shang
full_name: Teng, Shang
last_name: Teng
citation:
ama: Cheng S, Dey T, Edelsbrunner H, Facello M, Teng S. Sliver exudation. Journal
of the ACM. 2000;47(5):883-904. doi:10.1145/355483.355487
apa: Cheng, S., Dey, T., Edelsbrunner, H., Facello, M., & Teng, S. (2000). Sliver
exudation. Journal of the ACM. ACM. https://doi.org/10.1145/355483.355487
chicago: Cheng, Siu, Tamal Dey, Herbert Edelsbrunner, Michael Facello, and Shang
Teng. “Sliver Exudation.” Journal of the ACM. ACM, 2000. https://doi.org/10.1145/355483.355487.
ieee: S. Cheng, T. Dey, H. Edelsbrunner, M. Facello, and S. Teng, “Sliver exudation,”
Journal of the ACM, vol. 47, no. 5. ACM, pp. 883–904, 2000.
ista: Cheng S, Dey T, Edelsbrunner H, Facello M, Teng S. 2000. Sliver exudation.
Journal of the ACM. 47(5), 883–904.
mla: Cheng, Siu, et al. “Sliver Exudation.” Journal of the ACM, vol. 47,
no. 5, ACM, 2000, pp. 883–904, doi:10.1145/355483.355487.
short: S. Cheng, T. Dey, H. Edelsbrunner, M. Facello, S. Teng, Journal of the ACM
47 (2000) 883–904.
date_created: 2018-12-11T12:06:25Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-04-21T08:58:30Z
day: '01'
doi: 10.1145/355483.355487
extern: '1'
intvolume: ' 47'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 883 - 904
publication: Journal of the ACM
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: ACM
publist_id: '2118'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sliver exudation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '2000'
...
---
_id: '4008'
abstract:
- lang: eng
text: We formalize a notion of topological simplification within the framework of
a filtration, which is the history of a growing complex. We classify a topological
change that happens during growth as either a feature or noise depending on its
life-time or persistence within the filtration. We give fast algorithms for computing
persistence and experimental evidence for their speed and utility.
acknowledgement: Research by the first and third authors is partially supported by
ARO under grant DAAG55-98-1-0177. Research by the first author is also partially
supported by NSF under grant CCR-97-12088.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: David
full_name: Letscher, David
last_name: Letscher
- first_name: Afra
full_name: Zomorodian, Afra
last_name: Zomorodian
citation:
ama: 'Edelsbrunner H, Letscher D, Zomorodian A. Topological persistance and simplification.
In: Proceedings 41st Annual Symposium on Foundations of Computer Science.
IEEE; 2000:454-463. doi:10.1109/SFCS.2000.892133'
apa: 'Edelsbrunner, H., Letscher, D., & Zomorodian, A. (2000). Topological persistance
and simplification. In Proceedings 41st Annual Symposium on Foundations of
Computer Science (pp. 454–463). Washington, DC, United States: IEEE. https://doi.org/10.1109/SFCS.2000.892133'
chicago: Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological
Persistance and Simplification.” In Proceedings 41st Annual Symposium on Foundations
of Computer Science, 454–63. IEEE, 2000. https://doi.org/10.1109/SFCS.2000.892133.
ieee: H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistance
and simplification,” in Proceedings 41st Annual Symposium on Foundations of
Computer Science, Washington, DC, United States, 2000, pp. 454–463.
ista: 'Edelsbrunner H, Letscher D, Zomorodian A. 2000. Topological persistance and
simplification. Proceedings 41st Annual Symposium on Foundations of Computer Science.
FOCS: Foundations of Computer Science, 454–463.'
mla: Edelsbrunner, Herbert, et al. “Topological Persistance and Simplification.”
Proceedings 41st Annual Symposium on Foundations of Computer Science, IEEE,
2000, pp. 454–63, doi:10.1109/SFCS.2000.892133.
short: H. Edelsbrunner, D. Letscher, A. Zomorodian, in:, Proceedings 41st Annual
Symposium on Foundations of Computer Science, IEEE, 2000, pp. 454–463.
conference:
end_date: 2000-11-14
location: Washington, DC, United States
name: 'FOCS: Foundations of Computer Science'
start_date: 2000-11-12
date_created: 2018-12-11T12:06:24Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-04-25T06:53:21Z
day: '01'
doi: 10.1109/SFCS.2000.892133
extern: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 454 - 463
publication: Proceedings 41st Annual Symposium on Foundations of Computer Science
publication_identifier:
isbn:
- '0769508502'
publication_status: published
publisher: IEEE
publist_id: '2116'
quality_controlled: '1'
status: public
title: Topological persistance and simplification
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2000'
...
---
_id: '3624'
abstract:
- lang: eng
text: 'The state of a diploid population segregating for two alleles at each of
n loci is described by 22(n) genotype frequencies, or equivalently, by allele
frequencies and by multilocus moments or cumulants of various orders. These measures
of linkage disequilibrium cannot usually be determined, both because one cannot
tell whether a gene came from the maternal or paternal gamete, and because such
a large number of parameters cannot be estimated even from large samples. Simplifying
assumptions must therefore be made. This paper sets out methods for estimating
multilocus genotype frequencies which are appropriate for unlinked neutral loci,
and for populations that are ultimately derived by mixing of two source populations.
In such a hybrid population, all multilocus associations depend primarily on the
number of loci involved that derive from the maternal genome, and the number derived
from the paternal genome Allele frequencies may differ across loci, and the contribution
of each locus to multilocus associations may be scaled by the difference in allele
frequency between source populations for that locus (δp ≤ 1). For example, the
cumulant describing the association between genes i, j, k from the maternal genome,
and genes i, l from the paternal genome is K(tJ,k,iλ*), = δp(i)/2 δp(J) δp(k)
δp(l) κ3,2. The state of the population is described by n allele frequencies;
n divergences, δp; and by a symmetric matrix of cumulants, κ(J,K) (J = 0 ,...,
n, K = 0 ,..., n). Expressions for these cumulants under short- and long-range
migration are given. Two methods for estimating the cumulants are described: a
simple method based on multivariate moments, and a maximum likelihood procedure,
which uses the Metropolis algorithm. Both methods perform well when tested against
simulations with two or four loci.'
acknowledgement: This work was supported by grant MMI09726 from the BBSRC/EPSRC, and
by the Darwin Trust of Edinburgh. I am grateful to W. G. Hill, L. Kruuk and M. Orive,
and to the referees, for their helpful comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Estimating multilocus linkage disequilibria. Heredity. 2000;84(3):373-389.
doi:10.1046/j.1365-2540.2000.00683.x
apa: Barton, N. H. (2000). Estimating multilocus linkage disequilibria. Heredity.
Nature Publishing Group. https://doi.org/10.1046/j.1365-2540.2000.00683.x
chicago: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity.
Nature Publishing Group, 2000. https://doi.org/10.1046/j.1365-2540.2000.00683.x.
ieee: N. H. Barton, “Estimating multilocus linkage disequilibria,” Heredity,
vol. 84, no. 3. Nature Publishing Group, pp. 373–389, 2000.
ista: Barton NH. 2000. Estimating multilocus linkage disequilibria. Heredity. 84(3),
373–389.
mla: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity,
vol. 84, no. 3, Nature Publishing Group, 2000, pp. 373–89, doi:10.1046/j.1365-2540.2000.00683.x.
short: N.H. Barton, Heredity 84 (2000) 373–389.
date_created: 2018-12-11T12:04:18Z
date_published: 2000-03-01T00:00:00Z
date_updated: 2023-05-02T12:04:03Z
day: '01'
doi: 10.1046/j.1365-2540.2000.00683.x
extern: '1'
external_id:
pmid:
- '10762407'
intvolume: ' 84'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/6886830
month: '03'
oa_version: None
page: 373 - 389
pmid: 1
publication: Heredity
publication_identifier:
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2759'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimating multilocus linkage disequilibria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3798'
abstract:
- lang: eng
text: Glutamate is the main excitatory transmitter in the mammalian CNS, mediating
fast synaptic transmission primarily by activation of AMPA-type glutamate receptor
channels. Both synaptic structure and a cell-specific molecular switch in the
AMPA receptor subunit expression are involved in the regulation of the synaptic
signaling time course.
acknowledgement: I thank Drs. J.R.P. Geiger, K. Haverkampf, and B. Taskin for helpful
discussions. This review is based on a lecture given in Lisbon in March 1998 on
the occasion of the first award of the Medinfar European Prize in Physiology. My
studies are supported by the Deutsche Forschungsgemeinschaft, the German Israeli
Foundation, and the Human Frontiers Science Program Organization. I regret that
many relevant papers could not be cited due to editorial restric-tions on the maximum
number of references.
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Jonas PM. The time course of signaling at central glutamatergic synapses. Physiology.
2000;15(2):83-89. doi:10.1152/physiologyonline.2000.15.2.83
apa: Jonas, P. M. (2000). The time course of signaling at central glutamatergic
synapses. Physiology. American Physiological Society. https://doi.org/10.1152/physiologyonline.2000.15.2.83
chicago: Jonas, Peter M. “The Time Course of Signaling at Central Glutamatergic
Synapses.” Physiology. American Physiological Society, 2000. https://doi.org/10.1152/physiologyonline.2000.15.2.83.
ieee: P. M. Jonas, “The time course of signaling at central glutamatergic synapses,”
Physiology, vol. 15, no. 2. American Physiological Society, pp. 83–89,
2000.
ista: Jonas PM. 2000. The time course of signaling at central glutamatergic synapses.
Physiology. 15(2), 83–89.
mla: Jonas, Peter M. “The Time Course of Signaling at Central Glutamatergic Synapses.”
Physiology, vol. 15, no. 2, American Physiological Society, 2000, pp. 83–89,
doi:10.1152/physiologyonline.2000.15.2.83.
short: P.M. Jonas, Physiology 15 (2000) 83–89.
date_created: 2018-12-11T12:05:14Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-02T11:57:50Z
day: '01'
doi: 10.1152/physiologyonline.2000.15.2.83
extern: '1'
external_id:
pmid:
- '11390884'
intvolume: ' 15'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 83 - 89
pmid: 1
publication: Physiology
publication_identifier:
issn:
- 1548-9213
publication_status: published
publisher: American Physiological Society
publist_id: '2412'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The time course of signaling at central glutamatergic synapses
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2000'
...
---
_id: '4004'
abstract:
- lang: eng
text: In this paper we introduce the abacus model of a simplex and use it to subdivide
a d-simplex into k(d) d-simplices all of the same volume and shape characteristics.
The construction is an extension of the subdivision method of Freudenthal [3]
and has been used by Goodman and Peters [4] to design smooth manifolds.
acknowledgement: NSF under Grant DMS 98-73945, NSF under Grant CCR-96-19542 and by
ARO under Grant DAAG55- 98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Daniel
full_name: Grayson, Daniel
last_name: Grayson
citation:
ama: Edelsbrunner H, Grayson D. Edgewise subdivision of a simplex. Discrete &
Computational Geometry. 2000;24(4):707-719. doi:10.1007/s004540010063
apa: Edelsbrunner, H., & Grayson, D. (2000). Edgewise subdivision of a simplex.
Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s004540010063
chicago: Edelsbrunner, Herbert, and Daniel Grayson. “Edgewise Subdivision of a Simplex.”
Discrete & Computational Geometry. Springer, 2000. https://doi.org/10.1007/s004540010063.
ieee: H. Edelsbrunner and D. Grayson, “Edgewise subdivision of a simplex,” Discrete
& Computational Geometry, vol. 24, no. 4. Springer, pp. 707–719, 2000.
ista: Edelsbrunner H, Grayson D. 2000. Edgewise subdivision of a simplex. Discrete
& Computational Geometry. 24(4), 707–719.
mla: Edelsbrunner, Herbert, and Daniel Grayson. “Edgewise Subdivision of a Simplex.”
Discrete & Computational Geometry, vol. 24, no. 4, Springer, 2000,
pp. 707–19, doi:10.1007/s004540010063.
short: H. Edelsbrunner, D. Grayson, Discrete & Computational Geometry 24 (2000)
707–719.
date_created: 2018-12-11T12:06:23Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-05-02T11:43:59Z
day: '01'
doi: 10.1007/s004540010063
extern: '1'
intvolume: ' 24'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 707 - 719
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2119'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edgewise subdivision of a simplex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 24
year: '2000'
...
---
_id: '3923'
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
the Journal of the Boehringer Ingelheim Fonds. 2000;15(1):68-71.'
apa: 'Cremer, S. (2000). Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
The Journal of the Boehringer Ingelheim Fonds. Hippokrates.'
chicago: 'Cremer, Sylvia. “Paternity Analysis with AFLPs in Cardiocondyla Ants.”
Futura: The Journal of the Boehringer Ingelheim Fonds. Hippokrates, 2000.'
ieee: 'S. Cremer, “Paternity analysis with AFLPs in Cardiocondyla ants,” Futura:
the Journal of the Boehringer Ingelheim Fonds, vol. 15, no. 1. Hippokrates,
pp. 68–71, 2000.'
ista: 'Cremer S. 2000. Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
the Journal of the Boehringer Ingelheim Fonds. 15(1), 68–71.'
mla: 'Cremer, Sylvia. “Paternity Analysis with AFLPs in Cardiocondyla Ants.” Futura:
The Journal of the Boehringer Ingelheim Fonds, vol. 15, no. 1, Hippokrates,
2000, pp. 68–71.'
short: 'S. Cremer, Futura: The Journal of the Boehringer Ingelheim Fonds 15 (2000)
68–71.'
date_created: 2018-12-11T12:05:55Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-02T11:47:47Z
day: '01'
extern: '1'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 68 - 71
publication: 'Futura: the Journal of the Boehringer Ingelheim Fonds'
publication_identifier:
issn:
- 0179-6372
publication_status: published
publisher: Hippokrates
publist_id: '2228'
status: public
title: Paternity analysis with AFLPs in Cardiocondyla ants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2000'
...
---
_id: '3548'
abstract:
- lang: eng
text: Simultaneous recording from large numbers of neurons is a prerequisite for
understanding their cooperative behavior. Various recording techniques and spike
separation methods are being used toward this goal. However, the error rates involved
in spike separation have not yet been quantified. We studied the separation reliability
of “tetrode” (4-wire electrode) recorded spikes by monitoring simultaneously from
the same cell intracellularly with a glass pipette and extracellularly with a
tetrode. With manual spike sorting, we found a trade-off between Type I and Type
II errors, with errors typically ranging from 0 to 30% depending on the amplitude
and firing pattern of the cell, the similarity of the waveshapes of neighboring
neurons, and the experience of the operator. Performance using only a single wire
was markedly lower, indicating the advantages of multiple-site monitoring techniques
over single-wire recordings. For tetrode recordings, error rates were increased
by burst activity and during periods of cellular synchrony. The lowest possible
separation error rates were estimated by a search for the best ellipsoidal cluster
shape. Human operator performance was significantly below the estimated optimum.
Investigation of error distributions indicated that suboptimal performance was
caused by inability of the operators to mark cluster boundaries accurately in
a high-dimensional feature space. We therefore hypothesized that automatic spike-sorting
algorithms have the potential to significantly lower error rates. Implementation
of a semi-automatic classification system confirms this suggestion, reducing errors
close to the estimated optimum, in the range 0-8%.
acknowledgement: The costs of publication of this article were defrayed in part by
the payment of page charges. The article must therefore be hereby marked ‘‘advertisement’
’in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank
R. Bruno for performing cluster analysis and drawing our attention to the AutoClass
program, M. Recce and P. Mitra for suggestions withdata analysis and comments on
the manuscript, C. King, G. Dragoi, and X.Leinekugel for performing cluster analysis,
and J. Hetke and K. Wise for supplying silicon probes. The data used in this paper
are available on request by e-mail to G. Buzsaki. This work was supported by National
Institutes of Health Grants NS-34994,413 MH-54671, and MH-12403 (to D. A. Henze)
and by the Epilepsy Foundationof America (to D. A. Henze).
article_processing_charge: No
article_type: original
author:
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. Accuracy of tetrode spike
separation as determined by simultaneous intracellular and extracellular measurements.
Journal of Neurophysiology. 2000;84(1):401-414. doi:10.1152/jn.2000.84.1.401
apa: Harris, K., Henze, D., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000).
Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.401
chicago: Harris, Kenneth, Darrell Henze, Jozsef L Csicsvari, Hajima Hirase, and
György Buzsáki. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous
Intracellular and Extracellular Measurements.” Journal of Neurophysiology.
American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.401.
ieee: K. Harris, D. Henze, J. L. Csicsvari, H. Hirase, and G. Buzsáki, “Accuracy
of tetrode spike separation as determined by simultaneous intracellular and extracellular
measurements,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 401–414, 2000.
ista: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. 2000. Accuracy of tetrode
spike separation as determined by simultaneous intracellular and extracellular
measurements. Journal of Neurophysiology. 84(1), 401–414.
mla: Harris, Kenneth, et al. “Accuracy of Tetrode Spike Separation as Determined
by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology,
vol. 84, no. 1, American Physiological Society, 2000, pp. 401–14, doi:10.1152/jn.2000.84.1.401.
short: K. Harris, D. Henze, J.L. Csicsvari, H. Hirase, G. Buzsáki, Journal of Neurophysiology
84 (2000) 401–414.
date_created: 2018-12-11T12:03:54Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:16:45Z
day: '01'
doi: 10.1152/jn.2000.84.1.401
extern: '1'
external_id:
pmid:
- '10899214 '
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 401 - 414
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2837'
quality_controlled: '1'
status: public
title: Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3532'
abstract:
- lang: eng
text: Multichannel tetrode array recording in awake behaving animals provides a
powerful method to record the activity of large numbers of neurons. The power
of this method could be extended if further information concerning the intracellular
state of the neurons could be extracted from the extracellularly recorded signals.
Toward this end, we have simultaneously recorded intracellular and extracellular
signals from hippocampal CA1 pyramidal cells and interneurons in the anesthetized
rat. We found that several intracellular parameters can be deduced from extracellular
spike waveforms. The width of the intracellular action potential is defined precisely
by distinct points on the extracellular spike. Amplitude changes of the intracellular
action potential are reflected by changes in the amplitude of the initial negative
phase of the extracellular spike, and these amplitude changes are dependent on
the state of the network. In addition, intracellular recordings from dendrites
with simultaneous extracellular recordings from the soma indicate that, on average,
action potentials are initiated in the perisomatic region and propagate to the
dendrites at 1.68 m/s. Finally we determined that a tetrode in hippocampal area
CA1 theoretically should be able to record electrical signals from similar to
1,000 neurons. Of these, 60-100 neurons should generate spikes of sufficient amplitude
to be detectable from the noise and to allow for their separation using current
spatial clustering methods. This theoretical maximum is in contrast to the approximately
six units that are usually detected per tetrode. From this, we conclude that a
large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral
condition.
acknowledgement: We thank M. Recce for comments on the manuscript and J. Hetke and
K.Wise for supplying us with the silicon probes (1P41RR09754).This work was supported
by National Institutes of Health Grants NS-34994,MH-54671, and MH-12403 (to D.
A. Henze), the Epilepsy Foundation of American (D. A.Henze), and an Eotvos fellowship
(Z. Borhegyi).
article_processing_charge: No
article_type: original
author:
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Zsolt
full_name: Borhegyi, Zsolt
last_name: Borhegyi
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 2000;84(1):390-400. doi:10.1152/jn.2000.84.1.390
apa: Henze, D., Borhegyi, Z., Csicsvari, J. L., Mamiya, A., Harris, K., & Buzsáki,
G. (2000). Intracellular features predicted by extracellular recordings in the
hippocampus in vivo. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.390
chicago: Henze, Darrell, Zsolt Borhegyi, Jozsef L Csicsvari, Akira Mamiya, Kenneth
Harris, and György Buzsáki. “Intracellular Features Predicted by Extracellular
Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology. American
Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.390.
ieee: D. Henze, Z. Borhegyi, J. L. Csicsvari, A. Mamiya, K. Harris, and G. Buzsáki,
“Intracellular features predicted by extracellular recordings in the hippocampus
in vivo,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 390–400, 2000.
ista: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. 2000. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 84(1), 390–400.
mla: Henze, Darrell, et al. “Intracellular Features Predicted by Extracellular Recordings
in the Hippocampus in Vivo.” Journal of Neurophysiology, vol. 84, no. 1,
American Physiological Society, 2000, pp. 390–400, doi:10.1152/jn.2000.84.1.390.
short: D. Henze, Z. Borhegyi, J.L. Csicsvari, A. Mamiya, K. Harris, G. Buzsáki,
Journal of Neurophysiology 84 (2000) 390–400.
date_created: 2018-12-11T12:03:49Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:31:13Z
day: '01'
doi: 10.1152/jn.2000.84.1.390
extern: '1'
external_id:
pmid:
- '10899213'
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 390 - 400
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2854'
quality_controlled: '1'
status: public
title: Intracellular features predicted by extracellular recordings in the hippocampus
in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3623'
abstract:
- lang: eng
text: 'We present the theoretical background to a new method for measuring genetic
variation for total fitness in Drosophila. The method allows heterozygous effects
on total fitness of whole wild-type chromosomes to be measured under normal demography
with overlapping generations. The wild-type chromosomes are competed against two
balancer chromosomes (B1, B2, say), providing a standard genotype B1/B2 against
which variation in the fitness effects of the wild-type chromosomes can be assessed.
Fitness can be assessed in two ways: (i) at equilibrium of all three chromosomes
under heterozygote advantage, and (ii) during displacement of one balancer by
the other. Equilibrium with all three chromosomes present will be achieved only
if the wild-type homozygote is not too fit, and if the fitnesses of the three
heterozygotes are not too unequal. These conditions were not satisfied for any
of a sample of 12 lethal-bearing chromosomes isolated from a random-bred laboratory
population of Drosophila. At equilibrium, genotypic frequencies show low sensitivity
to changes in genotypic fitness. Furthermore, where all four genotypes are viable
and fertile, supplementary information from cages with only two chromosomes present
and from direct measurements of pre-adult viability are required to estimate fitnesses
from frequencies. The invasion method has the advantages of a greater sensitivity
and of not requiring further data to estimate fitnesses if the wild-type homozygote
is fertile. However, it requires that multiple samples be taken as the invasion
progresses. In a discrete generation model, generation time influences fitness
estimates from this method and is difficult to estimate accurately from the data.
A full age-structured model can also be applied to the data from both types of
experiment. For the invasion method, this gives fitness estimates close to those
from the discrete generation model.'
acknowledgement: This work was supported by grant GR31/G09821 from the BBSRC, and
by fellowships from the Darwin Trust of Edinburgh and the NERC. We are grateful
to the referees for their helpful comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Patridge, Linda
last_name: Patridge
citation:
ama: Barton NH, Patridge L. Measuring fitness by means of balancer chromosomes.
Genetical Research. 2000;75(3):297-314. doi:10.1017/S0016672399004346
apa: Barton, N. H., & Patridge, L. (2000). Measuring fitness by means of balancer
chromosomes. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672399004346
chicago: Barton, Nicholas H, and Linda Patridge. “Measuring Fitness by Means of
Balancer Chromosomes.” Genetical Research. Cambridge University Press,
2000. https://doi.org/10.1017/S0016672399004346.
ieee: N. H. Barton and L. Patridge, “Measuring fitness by means of balancer chromosomes,”
Genetical Research, vol. 75, no. 3. Cambridge University Press, pp. 297–314,
2000.
ista: Barton NH, Patridge L. 2000. Measuring fitness by means of balancer chromosomes.
Genetical Research. 75(3), 297–314.
mla: Barton, Nicholas H., and Linda Patridge. “Measuring Fitness by Means of Balancer
Chromosomes.” Genetical Research, vol. 75, no. 3, Cambridge University
Press, 2000, pp. 297–314, doi:10.1017/S0016672399004346.
short: N.H. Barton, L. Patridge, Genetical Research 75 (2000) 297–314.
date_created: 2018-12-11T12:04:18Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-02T12:09:23Z
day: '01'
doi: 10.1017/S0016672399004346
extern: '1'
external_id:
pmid:
- '10893866'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 297 - 314
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2760'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Measuring fitness by means of balancer chromosomes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...
---
_id: '3555'
abstract:
- lang: eng
text: A sliver is a tetrahedron whose four vertices lie close to a plane and whose
perpendicular projection to that plane is a convex quadrilateral with no short
edge. Slivers are both undesirable and ubiquitous in 3-dimensional Delaunay triangulations.
Even when the point-set is well-spaced, slivers may result. This paper shows that
such a point set permits a small perturbation whose Delaunay triangulation contains
no slivers. It also gives deterministic algorithms that compute the perturbation
of n points in time O(n log n) with one processor and in time O(log n) with O(n)
processors.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Xiang
full_name: Li, Xiang
id: 4B7E523C-F248-11E8-B48F-1D18A9856A87
last_name: Li
- first_name: Gary
full_name: Miller, Gary
last_name: Miller
- first_name: Andreas
full_name: Stathopoulos, Andreas
last_name: Stathopoulos
- first_name: Dafna
full_name: Talmor, Dafna
last_name: Talmor
- first_name: Shang
full_name: Teng, Shang
last_name: Teng
- first_name: Alper
full_name: Üngör, Alper
last_name: Üngör
- first_name: Noel
full_name: Walkington, Noel
last_name: Walkington
citation:
ama: 'Edelsbrunner H, Li X, Miller G, et al. Smoothing and cleaning up slivers.
In: Proceedings of the 32nd Annual ACM Symposium on Theory of Computing.
ACM; 2000:273-277. doi:10.1145/335305.335338'
apa: 'Edelsbrunner, H., Li, X., Miller, G., Stathopoulos, A., Talmor, D., Teng,
S., … Walkington, N. (2000). Smoothing and cleaning up slivers. In Proceedings
of the 32nd annual ACM symposium on Theory of computing (pp. 273–277). Portland,
OR, USA: ACM. https://doi.org/10.1145/335305.335338'
chicago: Edelsbrunner, Herbert, Xiang Li, Gary Miller, Andreas Stathopoulos, Dafna
Talmor, Shang Teng, Alper Üngör, and Noel Walkington. “Smoothing and Cleaning
up Slivers.” In Proceedings of the 32nd Annual ACM Symposium on Theory of Computing,
273–77. ACM, 2000. https://doi.org/10.1145/335305.335338.
ieee: H. Edelsbrunner et al., “Smoothing and cleaning up slivers,” in Proceedings
of the 32nd annual ACM symposium on Theory of computing, Portland, OR, USA,
2000, pp. 273–277.
ista: 'Edelsbrunner H, Li X, Miller G, Stathopoulos A, Talmor D, Teng S, Üngör A,
Walkington N. 2000. Smoothing and cleaning up slivers. Proceedings of the 32nd
annual ACM symposium on Theory of computing. STOC: Symposium on the Theory of
Computing, 273–277.'
mla: Edelsbrunner, Herbert, et al. “Smoothing and Cleaning up Slivers.” Proceedings
of the 32nd Annual ACM Symposium on Theory of Computing, ACM, 2000, pp. 273–77,
doi:10.1145/335305.335338.
short: H. Edelsbrunner, X. Li, G. Miller, A. Stathopoulos, D. Talmor, S. Teng, A.
Üngör, N. Walkington, in:, Proceedings of the 32nd Annual ACM Symposium on Theory
of Computing, ACM, 2000, pp. 273–277.
conference:
end_date: 2000-05-23
location: Portland, OR, USA
name: 'STOC: Symposium on the Theory of Computing'
start_date: 2000-05-21
date_created: 2018-12-11T12:03:56Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-02T14:07:00Z
day: '01'
doi: 10.1145/335305.335338
extern: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 273 - 277
publication: Proceedings of the 32nd annual ACM symposium on Theory of computing
publication_identifier:
isbn:
- '9781581131840'
publication_status: published
publisher: ACM
publist_id: '2830'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Smoothing and cleaning up slivers
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '3492'
abstract:
- lang: eng
text: Analysis of presynaptic determinants of synaptic strength has been difficult
at cortical synapses, mainly due to the lack of direct access to presynaptic elements.
Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal
slices. The presynaptic action potential is very short during low-frequency stimulation
but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated
K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly,
suggesting that cumulative K+ channel inactivation mediates activity-dependent
spike broadening. Prolongation of the presynaptic voltage waveform leads to an
increase in the number of Ca2+ ions entering the terminal per action potential
and to a consecutive potentiation of evoked excitatory postsynaptic currents at
MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels
contributes to the control of efficacy of a glutamatergic synapse in the cortex.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating
K+ channels in hippocampal mossy fiber boutons. Neuron. 2000;28(3):927-939.
doi:10.1016/S0896-6273(00)00164-1
apa: Geiger, J., & Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+)
inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron.
Elsevier. https://doi.org/10.1016/S0896-6273(00)00164-1
chicago: Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+)
Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron.
Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00164-1.
ieee: J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by
fast-inactivating K+ channels in hippocampal mossy fiber boutons,” Neuron,
vol. 28, no. 3. Elsevier, pp. 927–939, 2000.
ista: Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by
fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3),
927–939.
mla: Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow
by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron,
vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:10.1016/S0896-6273(00)00164-1.
short: J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.
date_created: 2018-12-11T12:03:37Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-05-02T14:34:37Z
day: '01'
doi: 10.1016/S0896-6273(00)00164-1
extern: '1'
external_id:
pmid:
- '11163277'
intvolume: ' 28'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 927 - 939
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2895'
quality_controlled: '1'
status: public
title: Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels
in hippocampal mossy fiber boutons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '3542'
abstract:
- lang: eng
text: Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous
recording of neuronal ensembles in the behaving rat. A nonlinear interaction among
pyramidal neurons was observed during sharp wave (SPW)-related population bursts,
with stronger synchrony associated with more widespread spatial coherence. SPW
bursts emerged in the CA3a-b subregions and spread to CA3c before invading the
CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was
required to exert a detectable influence on CA1 pyramidal cells. Activity of some
CA3 pyramidal neurons differentially predicted the ripple-related discharge of
circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral
state, the coherent discharge of a small group of CA3 cells is the primary cause
of spiking activity in CA1 pyramidal neurons.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron.
2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5
apa: Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble
patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population
events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5
chicago: Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble
Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population
Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5.
ieee: J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns
of hippocampal CA3-CA1 neurons during sharp wave-associated population events,”
Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000.
ista: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2),
585–594.
mla: Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons
during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2,
Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5.
short: J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594.
date_created: 2018-12-11T12:03:52Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-02T14:26:07Z
day: '01'
doi: 10.1016/S0896-6273(00)00135-5
extern: '1'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 585 - 594
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2843'
quality_controlled: '1'
status: public
title: Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated
population events
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '3583'
abstract:
- lang: eng
text: The Delaunay triangulation of a finite point set is a central theme in computational
geometry. It finds its major application in the generation of meshes used in the
simulation of physical processes. This paper connects the predominantly combinatorial
work in classical computational geometry with the numerical interest in mesh generation.
It focuses on the two- and three-dimensional case and covers results obtained
during the twentieth century.
acknowledgement: Research is partially supported by the Army Research Office under
grant DAAG55-98-1-0177 and by the National Science Foundation under grants CCR-96-19542
and CCR-97-12088.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Triangulations and meshes in computational geometry. Acta
Numerica. 2000;9:133-213. doi:10.1017/S0962492900001331
apa: Edelsbrunner, H. (2000). Triangulations and meshes in computational geometry.
Acta Numerica. Cambridge University Press. https://doi.org/10.1017/S0962492900001331
chicago: Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.”
Acta Numerica. Cambridge University Press, 2000. https://doi.org/10.1017/S0962492900001331.
ieee: H. Edelsbrunner, “Triangulations and meshes in computational geometry,” Acta
Numerica, vol. 9. Cambridge University Press, pp. 133–213, 2000.
ista: Edelsbrunner H. 2000. Triangulations and meshes in computational geometry.
Acta Numerica. 9, 133–213.
mla: Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.”
Acta Numerica, vol. 9, Cambridge University Press, 2000, pp. 133–213, doi:10.1017/S0962492900001331.
short: H. Edelsbrunner, Acta Numerica 9 (2000) 133–213.
date_created: 2018-12-11T12:04:05Z
date_published: 2000-03-21T00:00:00Z
date_updated: 2023-05-02T12:20:27Z
day: '21'
doi: 10.1017/S0962492900001331
extern: '1'
intvolume: ' 9'
language:
- iso: eng
month: '03'
oa_version: None
page: 133 - 213
publication: Acta Numerica
publication_status: published
publisher: Cambridge University Press
publist_id: '2802'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulations and meshes in computational geometry
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 9
year: '2000'
...
---
_id: '3572'
abstract:
- lang: eng
text: "Allzulange wurde die spielhafte Beschäftigung als Gegensatz zu ernsthafter
Arbeit gesehen. Dieser Artikel propagiert die spielerische Untersuchung von Kreis-
und Kugelmengen. Gleichzeitig belegt er die nutzbare Anwendung\r\nvon elementaren
Einsichten in der Molekularbiologie und allgemeiner\r\nin der Beschreibung von
Form und Verformung."
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung.
In: Zur Kunst Des Formalen Denkens. Passagen Verlag; 2000:153-171.'
apa: Edelsbrunner, H. (2000). Spielereien mit Kreisen und Kugeln. Zum Thema Form
und Verformung. In Zur Kunst des formalen Denkens (pp. 153–171). Passagen
Verlag.
chicago: Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form
Und Verformung.” In Zur Kunst Des Formalen Denkens, 153–71. Passagen Verlag,
2000.
ieee: H. Edelsbrunner, “Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung,”
in Zur Kunst des formalen Denkens, Passagen Verlag, 2000, pp. 153–171.
ista: 'Edelsbrunner H. 2000.Spielereien mit Kreisen und Kugeln. Zum Thema Form und
Verformung. In: Zur Kunst des formalen Denkens. , 153–171.'
mla: Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form
Und Verformung.” Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000,
pp. 153–71.
short: H. Edelsbrunner, in:, Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000,
pp. 153–171.
date_created: 2018-12-11T12:04:01Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-02T13:07:14Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 153 - 171
publication: Zur Kunst des formalen Denkens
publication_identifier:
isbn:
- '3851653580'
publication_status: published
publisher: Passagen Verlag
publist_id: '2813'
quality_controlled: '1'
status: public
title: Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '3491'
abstract:
- lang: eng
text: Fast and reliable activation of inhibitory interneurons is critical for the
stability of cortical neuronal networks. Active conductances in dendrites may
facilitate interneuron activation, but direct experimental evidence was unavailable.
Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons
revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous
recordings from dendrites and somata suggested that action potential initiation
occurs preferentially in the axon with long threshold stimuli, but can be shifted
to somatodendritic sites when brief stimuli are applied. After initiation, action
potentials propagate over the somatodendritic domain with constant amplitude,
high velocity, and reliability, even during high-frequency trains.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action
potentials in interneuron dendrites. Science. 2000;287(5451):295-300. doi:10.1126/science.287.5451.295
apa: Martina, M., Vida, I., & Jonas, P. M. (2000). Distal initiation and active
propagation of action potentials in interneuron dendrites. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.287.5451.295
chicago: Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active
Propagation of Action Potentials in Interneuron Dendrites.” Science. American
Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.287.5451.295.
ieee: M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation
of action potentials in interneuron dendrites,” Science, vol. 287, no.
5451. American Association for the Advancement of Science, pp. 295–300, 2000.
ista: Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation
of action potentials in interneuron dendrites. Science. 287(5451), 295–300.
mla: Martina, Marco, et al. “Distal Initiation and Active Propagation of Action
Potentials in Interneuron Dendrites.” Science, vol. 287, no. 5451, American
Association for the Advancement of Science, 2000, pp. 295–300, doi:10.1126/science.287.5451.295.
short: M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-01-14T00:00:00Z
date_updated: 2023-05-03T07:55:32Z
day: '14'
doi: 10.1126/science.287.5451.295
extern: '1'
external_id:
pmid:
- '10634782'
intvolume: ' 287'
issue: '5451'
language:
- iso: eng
month: '01'
oa_version: None
page: 295 - 300
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distal initiation and active propagation of action potentials in interneuron
dendrites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 287
year: '2000'
...
---
_id: '3489'
abstract:
- lang: eng
text: We have examined factors that determine the strength and dynamics of GABAergic
synapses between interneurons [dentate gyrus basket cells (BCs)] and principal
neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal
slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular
Cl− concentration showed a fast rise and a biexponential decay, with mean time
constants of 2 and 9 msec. The mean quantal conductance change, determined directly
at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release
at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis
of IPSC peak amplitudes and numbers of failures by multiple probability compound
binomial analysis indicated that synaptic transmission at the BC–GC synapse involves
three to seven release sites, each of which releases transmitter with high probability
(∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression
(PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery
from depression occurred with a time constant of 2 sec. Paired-pulse depression
was mainly presynaptic in origin but appeared to be independent of previous release.
Synaptic transmission at the BC–GC synapse showed frequency-dependent depression,
with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials.
The relative stability of transmission at the BC–GC synapse is consistent with
a model in which an activity-dependent gating mechanism reduces release probability
and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus
several mechanisms converge on the generation of powerful and sustained transmission
at interneuron–principal neuron synapses in hippocampal circuits.
acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft
(SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B)
to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger,
F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically
reading this manuscript. We also thank A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a
hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000
apa: Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal
GABA release at a hippocampal interneuron-principal neuron synapse. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000
chicago: Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.
ieee: U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience,
vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.
ista: Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
20(15), 5594–5607.
mla: Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607,
doi:10.1523/JNEUROSCI.20-15-05594.2000.
short: U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-08-01T00:00:00Z
date_updated: 2023-05-03T08:18:39Z
day: '01'
doi: 10.1523/JNEUROSCI.20-15-05594.2000
extern: '1'
external_id:
pmid:
- '10908596'
intvolume: ' 20'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/
month: '08'
oa: 1
oa_version: Published Version
page: 5594 - 5607
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2898'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal
neuron synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3490'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that can be induced
either by low-frequency stimulation of presynaptic fibers or in an associative
manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated
the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus
using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices.
Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with
a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude
to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant
to the application of D-AP-5, indicating that it is independent of NMDA receptors.
In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine,
indicating the involvement of metabotropic glutamate receptors. Furthermore, associative
LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic
action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin
GVIA, a selective N-type channel blocker, abolished the induction of associative
LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist,
inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting
presynaptic transmitter release. OH-DPAT also inhibited the induction of associative
LTD, suggesting that the involvement of N-type channels makes synaptic plasticity
accessible to modulation by neurotransmitters. Thus, the modulation of N-type
Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal
neurons.
acknowledgement: This work was supported by a grant from the Deutsche Forschungsgemeinschaft
Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation
(J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically
reading this manuscript and A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Claus
full_name: Normann, Claus
last_name: Normann
- first_name: Diana
full_name: Peckys, Diana
last_name: Peckys
- first_name: Christian
full_name: Schulze, Christian
last_name: Schulze
- first_name: Jörg
full_name: Walden, Jörg
last_name: Walden
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
citation:
ama: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative
long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+)
channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000
apa: Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger,
J. (2000). Associative long-term depression in the hippocampus is dependent on
postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000
chicago: Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas,
and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience.
Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.
ieee: C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger,
“Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society
for Neuroscience, pp. 8290–8297, 2000.
ista: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000.
Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.
mla: Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience,
vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000.
short: C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger,
Journal of Neuroscience 20 (2000) 8290–8297.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-11-15T00:00:00Z
date_updated: 2023-05-03T08:02:52Z
day: '15'
doi: 10.1523/JNEUROSCI.20-22-08290.2000
extern: '1'
external_id:
pmid:
- '11069935'
intvolume: ' 20'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/
month: '11'
oa: 1
oa_version: Published Version
page: 8290 - 8297
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2897'
quality_controlled: '1'
status: public
title: Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3149'
abstract:
- lang: eng
text: The prohormone convertases (PCs) are an evolutionarily ancient group of proteases
required for the maturation of neuropeptide and peptide hormone precursors. In
Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado),
is required for normal hatching behavior, and immunoblotting data indicate that
flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires
7B2, a helper protein for productive maturation, we searched the fly data base
for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone
encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were
subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and
rat 7B2 were used as controls. Although active mPC2 was detected in medium in
the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon
coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was
synthesized but not secreted from HEK-293 cells. However, when dPC2 and either
d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive
dPC2 was secreted into the medium, coincident with the appearance of PC2 activity.
Expression and secretion of dPC2 enzyme activity thus appears to require insect
cell-specific posttranslational processing events. The significant differences
in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required
for secretion of dPC2 and zymogen conversion occurring intracellularly in the
case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific
requirements for maturation and secretion that can be met only in insect cells.
acknowledgement: This work was supported by National Institutes of Health Grants DK49703
(to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section
1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory
and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans
PC2 expression vector, and Joelle Finley for assistance with cell culture.
article_processing_charge: No
article_type: original
author:
- first_name: Jae
full_name: Hwang, Jae
last_name: Hwang
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
- first_name: Paul
full_name: Taghert, Paul
last_name: Taghert
- first_name: Iris
full_name: Lindberg, Iris
last_name: Lindberg
citation:
ama: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila
melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing
and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893.
doi:10.1074/jbc.M000032200 '
apa: 'Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000).
Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 '
chicago: 'Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg.
“Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect
Cell Specific Processing and Secretion.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .'
ieee: 'J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion,” Journal of Biological Chemistry, vol. 275, no.
23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893,
2000.'
ista: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.'
mla: 'Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase
2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological
Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular
Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .'
short: J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological
Chemistry 275 (2000) 17886–17893.
date_created: 2018-12-11T12:01:40Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T08:47:13Z
day: '09'
doi: '10.1074/jbc.M000032200 '
extern: '1'
external_id:
pmid:
- '10749852'
intvolume: ' 275'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 17886 - 17893
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '3546'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 275
year: '2000'
...
---
_id: '2602'
abstract:
- lang: eng
text: Although presynaptic localization of mGluR7 is well established, the mechanism
by which the receptor may control Ca2+ channels in neurons is still unknown. We
show here that cultured cerebellar granule cells express native metabotropic glutamate
receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was
also expressed in cell bodies. This allowed us to study the effect of the transfected
receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited
P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis
toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating
the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics
of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel
subunit, but was abolished by quenching βγ subunits with specific intracellular
peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action
of mGluR7, suggesting that both G-protein βγ and αo subunits were required to
mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory
action of mGluR7, suggesting that a coincident activation of PLC by the G-protein
βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition
of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC)
abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent
IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release
was required for PKC-dependent inhibition of the Ca2+ channels. Possible control
of synaptic transmission by the present mechanisms is discussed.
acknowledgement: This work was supported by Centre National de la Recherche Scientifique
and grants from Association Française contre les Myopathies, Fondation pour la Recherche
Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J.
P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J.
Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France)
for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the
anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal
antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Prezèau, Laurent
last_name: Prezèau
- first_name: Michel
full_name: De Waard, Michel
last_name: De Waard
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Joël
full_name: Bockaërt, Joël
last_name: Bockaërt
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
citation:
ama: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience.
2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000
apa: Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni,
L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic
glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000
chicago: Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël
Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels
by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway
in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.
ieee: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni,
“Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons,” Journal of
Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.
ista: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21),
7896–7904.
mla: Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the
Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.”
Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000,
pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.
short: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni,
Journal of Neuroscience 20 (2000) 7896–7904.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:48:17Z
day: '01'
doi: 10.1523/JNEUROSCI.20-21-07896.2000
extern: '1'
external_id:
pmid:
- '11050109'
intvolume: ' 20'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/
month: '11'
oa: 1
oa_version: Published Version
page: 7896 - 7904
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4296'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '2603'
abstract:
- lang: eng
text: Aggregation of neurotransmitter receptors at pre- and postsynaptic structures
is crucial for efficient neuronal communication. In contrast to the wealth of
information about postsynaptic specializations, little is known about the molecular
organization of presynaptic membrane proteins. We show here that the metabotropic
glutamate receptor mGluR7a, which localizes specifically to presynaptic active
zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous
systems induces coclustering dependent upon the extreme C terminus of mGluR7a
and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses
in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic
sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not
cluster. These results suggest that PICK1 is a component of the presynaptic machinery
involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.
acknowledgement: 'We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P.
J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent
preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work
was supported by the Pew Chari-table Trust and National Institutes of Health grants
NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship
from IPSEN Foundation (H. B.). '
article_processing_charge: No
article_type: original
author:
- first_name: Hélène
full_name: Boudin, Hélène
last_name: Boudin
- first_name: Andrew
full_name: Doan, Andrew
last_name: Doan
- first_name: Jun
full_name: Xia, Jun
last_name: Xia
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Richard
full_name: Huganir, Richard
last_name: Huganir
- first_name: Paul
full_name: Worley, Paul
last_name: Worley
- first_name: Ann
full_name: Craig, Ann
last_name: Craig
citation:
ama: Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires
the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6
apa: Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., &
Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain
binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6
chicago: Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir,
Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1
PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6.
ieee: H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1
PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497,
2000.
ista: Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000.
Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site.
Neuron. 28(2), 485–497.
mla: Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1
PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97,
doi:10.1016/S0896-6273(00)00127-6.
short: H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig,
Neuron 28 (2000) 485–497.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:41:55Z
day: '01'
doi: 10.1016/S0896-6273(00)00127-6
extern: '1'
external_id:
pmid:
- '11144358'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 485 - 497
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4295'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '2732'
abstract:
- lang: eng
text: 'We consider a quantum particle moving in a harmonic exterior potential and
linearly coupled to a heat bath of quantum oscillators. Caldeira and Leggett derived
the Fokker Planck equation with friction for the Wigner distribution of the particle
in the large-temperature limit: however, their (nonrigorous) derivation was not
free of criticism, especially since the limiting equation is not of Lindblad form.
In this paper we recover the correct form of their result in a rigorous way. We
also point out that the source of the diffusion is physically restrictive under
this scaling. We investigate the model at a fixed temperature and in the large-time
limit, where the origin of the diffusion is a cumulative effect of many resonant
collisions. We obtain a heat equation with a friction term for the radial process
in phase space and we prove the Einstein relation in this case.'
acknowledgement: The authors are indebted to H. Spohn for discussions. F.C. and L.E.
were partially supported by the Erwin Schrödinger Institute in Vienna (Austria)
during their visit, and they thank this institution for its hospitality. This work
was supported by the TMR-Network ``Asymptotic Methods in Kinetic Theory'' number
ERB FMBX CT97 0157 (F.C., F.F., and P.A.M.) and by NSF Grant DMS-9970323 (L.E.).
article_processing_charge: No
article_type: original
author:
- first_name: François
full_name: Castella, François
last_name: Castella
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Florian
full_name: Frommlet, Florian
last_name: Frommlet
- first_name: Peter
full_name: Markowich, Peter
last_name: Markowich
citation:
ama: Castella F, Erdös L, Frommlet F, Markowich P. Fokker-Planck equations as scaling
limits of reversible quantum systems. Journal of Statistical Physics. 2000;100(3-4):543-601.
doi:10.1023/A:1018667323830
apa: Castella, F., Erdös, L., Frommlet, F., & Markowich, P. (2000). Fokker-Planck
equations as scaling limits of reversible quantum systems. Journal of Statistical
Physics. Springer. https://doi.org/10.1023/A:1018667323830
chicago: Castella, François, László Erdös, Florian Frommlet, and Peter Markowich.
“Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal
of Statistical Physics. Springer, 2000. https://doi.org/10.1023/A:1018667323830.
ieee: F. Castella, L. Erdös, F. Frommlet, and P. Markowich, “Fokker-Planck equations
as scaling limits of reversible quantum systems,” Journal of Statistical Physics,
vol. 100, no. 3–4. Springer, pp. 543–601, 2000.
ista: Castella F, Erdös L, Frommlet F, Markowich P. 2000. Fokker-Planck equations
as scaling limits of reversible quantum systems. Journal of Statistical Physics.
100(3–4), 543–601.
mla: Castella, François, et al. “Fokker-Planck Equations as Scaling Limits of Reversible
Quantum Systems.” Journal of Statistical Physics, vol. 100, no. 3–4, Springer,
2000, pp. 543–601, doi:10.1023/A:1018667323830.
short: F. Castella, L. Erdös, F. Frommlet, P. Markowich, Journal of Statistical
Physics 100 (2000) 543–601.
date_created: 2018-12-11T11:59:18Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T09:02:11Z
day: '01'
doi: 10.1023/A:1018667323830
extern: '1'
intvolume: ' 100'
issue: 3-4
language:
- iso: eng
month: '01'
oa_version: None
page: 543 - 601
publication: Journal of Statistical Physics
publication_identifier:
issn:
- 0022-4715
publication_status: published
publisher: Springer
publist_id: '4160'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fokker-Planck equations as scaling limits of reversible quantum systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 100
year: '2000'
...
---
_id: '2731'
abstract:
- lang: eng
text: We study the time evolution of a quantum particle in a Gaussian random environment.
We show that in the weak coupling limit the Wigner distribution of the wave function
converges to a solution of a linear Boltzmann equation globally in time. The Boltzmann
collision kernel is given by the Born approximation of the quantum differential
scattering cross section.
acknowledgement: Partially supported by U.S. National Science Foundation grants DMS-9403462,
9703752. We would like to thank H. Spohn for his several comments and discussions
on this project. Part of this work was done during the time when L. E. visited the
Erwin Schrödinger Institute in Vienna and when both authors visited the Center of
Theoretical Sciences in Taiwan. We thank them for the hospitality and the support
of this work.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Linear Boltzmann equation as the weak coupling limit of a random
Schrödinger equation. Communications on Pure and Applied Mathematics. 2000;53(6):667-735.
doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
apa: Erdös, L., & Yau, H. (2000). Linear Boltzmann equation as the weak coupling
limit of a random Schrödinger equation. Communications on Pure and Applied
Mathematics. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
chicago: Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling
Limit of a Random Schrödinger Equation.” Communications on Pure and Applied
Mathematics. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5.
ieee: L. Erdös and H. Yau, “Linear Boltzmann equation as the weak coupling limit
of a random Schrödinger equation,” Communications on Pure and Applied Mathematics,
vol. 53, no. 6. Wiley-Blackwell, pp. 667–735, 2000.
ista: Erdös L, Yau H. 2000. Linear Boltzmann equation as the weak coupling limit
of a random Schrödinger equation. Communications on Pure and Applied Mathematics.
53(6), 667–735.
mla: Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling
Limit of a Random Schrödinger Equation.” Communications on Pure and Applied
Mathematics, vol. 53, no. 6, Wiley-Blackwell, 2000, pp. 667–735, doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5.
short: L. Erdös, H. Yau, Communications on Pure and Applied Mathematics 53 (2000)
667–735.
date_created: 2018-12-11T11:59:18Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-03T09:09:04Z
day: '01'
doi: 10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
extern: '1'
external_id:
arxiv:
- math-ph/9901020
intvolume: ' 53'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: Preprint
page: 667 - 735
publication: Communications on Pure and Applied Mathematics
publication_identifier:
issn:
- 0010-3640
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4161'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linear Boltzmann equation as the weak coupling limit of a random Schrödinger
equation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 53
year: '2000'
...
---
_id: '2710'
abstract:
- lang: eng
text: In this paper we describe an intrinsically geometric way of producing magnetic
fields on §3 and $\R^3$ for which the corresponding Dirac operators have a non-trivial
kernel. In many cases we are able to compute the dimension of the kernel. In particular
we can give examples where the kernel has any given dimension. This generalizes
the examples of Loss and Yau (Commun. Math. Phys. 104 (1986) 283-290).
acknowledgement: L. Erdös was supported by the N.S.F. grant DMS-9970323. J. P. Solovej
was supported in parts by the EU TMR-grant FMRX-CT 96-0001 by MaPhySto — Centre
for Mathematical Physics and Stochastics, funded by a grant from The Danish National
Research Foundation and by a grant from the Danish Natural Science Research Council.
alternative_title:
- AMS/IP Studies in Advanced Mathematics
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. The kernel of Dirac operators on S3 and R3. In: Differential Equations
and Mathematical Physics. Vol 16. American Mathematical Society; 2000:111-119.
doi:10.1090/amsip/016'
apa: Erdös, L. (2000). The kernel of Dirac operators on S3 and R3. In Differential
Equations and Mathematical Physics (Vol. 16, pp. 111–119). American Mathematical
Society. https://doi.org/10.1090/amsip/016
chicago: Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” In Differential
Equations and Mathematical Physics, 16:111–19. American Mathematical Society,
2000. https://doi.org/10.1090/amsip/016.
ieee: L. Erdös, “The kernel of Dirac operators on S3 and R3,” in Differential
Equations and Mathematical Physics, vol. 16, American Mathematical Society,
2000, pp. 111–119.
ista: 'Erdös L. 2000.The kernel of Dirac operators on S3 and R3. In: Differential
Equations and Mathematical Physics. AMS/IP Studies in Advanced Mathematics, vol.
16, 111–119.'
mla: Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” Differential
Equations and Mathematical Physics, vol. 16, American Mathematical Society,
2000, pp. 111–19, doi:10.1090/amsip/016.
short: L. Erdös, in:, Differential Equations and Mathematical Physics, American
Mathematical Society, 2000, pp. 111–119.
date_created: 2018-12-11T11:59:12Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T09:37:03Z
day: '01'
doi: 10.1090/amsip/016
extern: '1'
external_id:
arxiv:
- math-ph/0001036
intvolume: ' 16'
language:
- iso: eng
month: '01'
oa_version: Preprint
page: 111 - 119
publication: Differential Equations and Mathematical Physics
publication_identifier:
isbn:
- '9780821821572'
publication_status: published
publisher: American Mathematical Society
publist_id: '4186'
quality_controlled: '1'
status: public
title: The kernel of Dirac operators on S3 and R3
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2000'
...
---
_id: '2733'
abstract:
- lang: eng
text: The Li-Yau semiclassical lower bound for the sum of the first N eigenvalues
of the Dirichlet–Laplacian is extended to Dirichlet–Laplacians with constant magnetic
fields. Our method involves a new diamagnetic inequality for constant magnetic
fields.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Michael
full_name: Loss, Michael
last_name: Loss
- first_name: Vitali
full_name: Vougalter, Vitali
last_name: Vougalter
citation:
ama: Erdös L, Loss M, Vougalter V. Diamagnetic behavior of sums Dirichlet eigenvalues.
Annales de l’Institut Fourier. 2000;50(3):891-907. doi:10.5802/aif.1777
apa: Erdös, L., Loss, M., & Vougalter, V. (2000). Diamagnetic behavior of sums
Dirichlet eigenvalues. Annales de l’Institut Fourier. Association des Annales
de l’Institut Fourier. https://doi.org/10.5802/aif.1777
chicago: Erdös, László, Michael Loss, and Vitali Vougalter. “Diamagnetic Behavior
of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier. Association
des Annales de l’Institut Fourier, 2000. https://doi.org/10.5802/aif.1777.
ieee: L. Erdös, M. Loss, and V. Vougalter, “Diamagnetic behavior of sums Dirichlet
eigenvalues,” Annales de l’Institut Fourier, vol. 50, no. 3. Association
des Annales de l’Institut Fourier, pp. 891–907, 2000.
ista: Erdös L, Loss M, Vougalter V. 2000. Diamagnetic behavior of sums Dirichlet
eigenvalues. Annales de l’Institut Fourier. 50(3), 891–907.
mla: Erdös, László, et al. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.”
Annales de l’Institut Fourier, vol. 50, no. 3, Association des Annales
de l’Institut Fourier, 2000, pp. 891–907, doi:10.5802/aif.1777.
short: L. Erdös, M. Loss, V. Vougalter, Annales de l’Institut Fourier 50 (2000)
891–907.
date_created: 2018-12-11T11:59:19Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T08:56:17Z
day: '01'
doi: 10.5802/aif.1777
extern: '1'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 891 - 907
publication: Annales de l'Institut Fourier
publication_identifier:
issn:
- 0373-0956
publication_status: published
publisher: Association des Annales de l'Institut Fourier
publist_id: '4159'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diamagnetic behavior of sums Dirichlet eigenvalues
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '2000'
...
---
_id: '2601'
abstract:
- lang: eng
text: Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene
can cause defects in development and function in the cerebellum. We introduced
the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje
cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term
depression and regression of multiple climbing fiber innervation, events significantly
impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by
this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a
key molecule for normal synapse formation, synaptic plasticity, and motor control
in the cerebellum.
article_processing_charge: No
article_type: original
author:
- first_name: Taeko
full_name: Ichise, Taeko
last_name: Ichise
- first_name: Masanobu
full_name: Kano, Masanobu
last_name: Kano
- first_name: Kouichi
full_name: Hashimoto, Kouichi
last_name: Hashimoto
- first_name: Dai
full_name: Yanagihara, Dai
last_name: Yanagihara
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Atsu
full_name: Aiba, Atsu
last_name: Aiba
citation:
ama: Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential
for long-term depression, synapse elimination, and motor coordination. Science.
2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832
apa: Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto,
R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term
depression, synapse elimination, and motor coordination. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832
chicago: Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki
Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar
Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor
Coordination.” Science. American Association for the Advancement of Science,
2000. https://doi.org/10.1126/science.288.5472.1832.
ieee: T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for
long-term depression, synapse elimination, and motor coordination,” Science,
vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835,
2000.
ista: Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki
M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression,
synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.
mla: Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term
Depression, Synapse Elimination, and Motor Coordination.” Science, vol.
288, no. 5472, American Association for the Advancement of Science, 2000, pp.
1832–35, doi:10.1126/science.288.5472.1832.
short: T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto,
M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T09:53:38Z
day: '09'
doi: 10.1126/science.288.5472.1832
extern: '1'
external_id:
pmid:
- '10846166 '
intvolume: ' 288'
issue: '5472'
language:
- iso: eng
month: '06'
oa_version: None
page: 1832 - 1835
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse
elimination, and motor coordination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 288
year: '2000'
...
---
_id: '2600'
abstract:
- lang: eng
text: 'The synaptic relationship between substance P (SP) and its receptor, i.e.
neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal
subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the
rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry
for NK1 and SP was performed. In electron microscopic double-immunolabeling study,
immunoreactivity for NK1R was detected with the silver-intensified gold method,
while immunoreactivity for SP was detected with peroxidase immunohistochemistry.
SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric)
contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo.
Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive
sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic
and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals
might not only act on NK1Rs facing the SP-containing axon terminals, but also
diffuse in the extracellular fluid for distances larger than the synaptic cleft
to act on NK1Rs at some distances from the synaptic sites. '
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Dan
full_name: Wang, Dan
last_name: Wang
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat. Neuroscience
Research. 2000;36(4):327-334. doi:10.1016/S0168-0102(00)00095-X'
apa: 'Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N.
(2000). The relationship between neurokinin-1 receptor and substance P in the
medullary dorsal horn: A light and electron microscopic immunohistochemical study
in the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(00)00095-X'
chicago: 'Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance
P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical
Study in the Rat.” Neuroscience Research. Elsevier, 2000. https://doi.org/10.1016/S0168-0102(00)00095-X.'
ieee: 'J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat,” Neuroscience
Research, vol. 36, no. 4. Elsevier, pp. 327–334, 2000.'
ista: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat. Neuroscience
Research. 36(4), 327–334.'
mla: 'Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance
P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical
Study in the Rat.” Neuroscience Research, vol. 36, no. 4, Elsevier, 2000,
pp. 327–34, doi:10.1016/S0168-0102(00)00095-X.'
short: J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience
Research 36 (2000) 327–334.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-03T10:47:06Z
day: '01'
doi: 10.1016/S0168-0102(00)00095-X
extern: '1'
external_id:
pmid:
- '10771111'
intvolume: ' 36'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 327 - 334
pmid: 1
publication: Neuroscience Research
publication_identifier:
issn:
- 0168-0102
publication_status: published
publisher: Elsevier
publist_id: '4298'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The relationship between neurokinin-1 receptor and substance P in the medullary
dorsal horn: A light and electron microscopic immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 36
year: '2000'
...
---
_id: '2598'
abstract:
- lang: eng
text: "There are many types of cerebellar ataxia, including ataxia due to congenital
or metabolic disorders and a paraneoplastic form in patients with gynecologic
cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic
syndrome is the only type of cerebellar ataxia associated with autoantibodies
against neuronal antigens. Often, the neuronal antigens are aberrantly expressed
by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar
ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the
ataxia by months to years in 80 percent of patients, and ataxia often occurs during
a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent
have anti–Purkinje-cell antibodies, some of which have the features of the neuronal
antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with
severe cerebellar ataxia that developed while they were in remission from Hodgkin's
disease. The antibody reacts specifically with the metabotropic glutamate receptor
mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family
of cell-surface receptors that transmit signals into the cell by coupling to guanine
nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the
serum of both patients blocked the glutamate-stimulated formation of inositol
phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the
injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid
space of mice caused severe, reversible ataxia. These results indicate that antineuronal
autoantibodies can cause disease of the central nervous system by blocking neuronal
receptors."
acknowledgement: "Supported in part by the Ministry of Education, Science, and Culture
of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology
Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr.
De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw
and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to
the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to
T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful
discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C.
Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E.
Koekkoek, K.J. Reus, and C. Vermeer for technical assistance."
article_processing_charge: No
article_type: original
author:
- first_name: Peter
full_name: Sillevis Smitt, Peter
last_name: Sillevis Smitt
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Bertie
full_name: De Leeuw, Bertie
last_name: De Leeuw
- first_name: Wiebe
full_name: Moll, Wiebe
last_name: Moll
- first_name: Michiel
full_name: Coesmans, Michiel
last_name: Coesmans
- first_name: Dick
full_name: Jaarsma, Dick
last_name: Jaarsma
- first_name: Sonja
full_name: Henzen Logmans, Sonja
last_name: Henzen Logmans
- first_name: Charles
full_name: Vecht, Charles
last_name: Vecht
- first_name: Chris
full_name: De Zeeuw, Chris
last_name: De Zeeuw
- first_name: Naotaka
full_name: Sekiyama, Naotaka
last_name: Sekiyama
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar
ataxia due to autoantibodies against a glutamate receptor. New England Journal
of Medicine. 2000;342(1):21-27. doi:10.1056/NEJM200001063420104
apa: Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma,
D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies
against a glutamate receptor. New England Journal of Medicine. Massachussetts
Medical Society. https://doi.org/10.1056/NEJM200001063420104
chicago: Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel
Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar
Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal
of Medicine. Massachussetts Medical Society, 2000. https://doi.org/10.1056/NEJM200001063420104.
ieee: P. Sillevis Smitt et al., “Paraneoplastic cerebellar ataxia due to
autoantibodies against a glutamate receptor,” New England Journal of Medicine,
vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.
ista: Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D,
Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000.
Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor.
New England Journal of Medicine. 342(1), 21–27.
mla: Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies
against a Glutamate Receptor.” New England Journal of Medicine, vol. 342,
no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:10.1056/NEJM200001063420104.
short: P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma,
S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto,
New England Journal of Medicine 342 (2000) 21–27.
date_created: 2018-12-11T11:58:35Z
date_published: 2000-01-06T00:00:00Z
date_updated: 2023-05-03T11:14:19Z
day: '06'
doi: 10.1056/NEJM200001063420104
extern: '1'
external_id:
pmid:
- '10620645'
intvolume: ' 342'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nejm.org/doi/full/10.1056/nejm200001063420104
month: '01'
oa: 1
oa_version: None
page: 21 - 27
pmid: 1
publication: New England Journal of Medicine
publication_identifier:
issn:
- 0028-4793
publication_status: published
publisher: Massachussetts Medical Society
publist_id: '4300'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate
receptor
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 342
year: '2000'
...
---
_id: '2599'
abstract:
- lang: eng
text: 'The synaptic relationship between substance P (SP) and its receptor, i.e.,
neurokinin-1 receptor (NK1R), was examined in the striatum of the rat by confocal
laser-scanning microscopy and electron microscopy. For confocal laser-scanning
microscopy, triple-immunofluorescence histochemistry was performed to label NK1R,
SP, and vesicular acetylcholine transporter (a specific marker for cholinergic
neurons). In electron microscopic double- immunolabeling study, immunoreactivity
for NK1R was detected with the silver- intensified gold method, while immunoreactivity
for SP was detected with peroxidase immunohistochemistry. Simultaneous immunolabeling
of NK1R and SP revealed significant mismatch at the synaptic level: although some
SP- immunopositive axon terminals were in synaptic contact with NK1R- immunopositive
sites of plasma membrane, NK1R-immunoreactivity was observed at both synaptic
and non-synaptic sites of plasma membrane. Thus, SP released from the sites remote
from NK1Rs might diffuse in the extracellular fluid to act, as a paracrine neurotransmitter,
on NK1Rs distant from its releasing site. SP neurotransmission in the striatum
might occur not only synaptically but also extrasynaptically. The SP-NK1R system
might constitute an association system within the striatum.'
acknowledgement: The authors are grateful for the photographic help of Ms. Yue-Ping Yuan, Mr. Akira Uesugi, Ms. Keiko Oka-moto,
Mr. Nobuyuki Kobayashi, and Mr. Hideki Itabashi. The authors also express their
gratitudes for the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine
and Pediatrics, Kadoma, Osaka, Japan
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Dan
full_name: Wang, Dan
last_name: Wang
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Relationship between
neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic
immunohistochemical study in the rat. Journal of Comparative Neurology.
2000;418(2):156-163. doi:10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z'
apa: 'Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N.
(2000). Relationship between neurokinin-1 receptor and substance P in the striatum:
Light and electron microscopic immunohistochemical study in the rat. Journal
of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z'
chicago: 'Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “Relationship between Neurokinin-1 Receptor and Substance P
in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the
Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z.'
ieee: 'J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Relationship
between neurokinin-1 receptor and substance P in the striatum: Light and electron
microscopic immunohistochemical study in the rat,” Journal of Comparative Neurology,
vol. 418, no. 2. Wiley-Blackwell, pp. 156–163, 2000.'
ista: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. Relationship
between neurokinin-1 receptor and substance P in the striatum: Light and electron
microscopic immunohistochemical study in the rat. Journal of Comparative Neurology.
418(2), 156–163.'
mla: 'Li, Jin, et al. “Relationship between Neurokinin-1 Receptor and Substance
P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in
the Rat.” Journal of Comparative Neurology, vol. 418, no. 2, Wiley-Blackwell,
2000, pp. 156–63, doi:10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z.'
short: J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of
Comparative Neurology 418 (2000) 156–163.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-03-06T00:00:00Z
date_updated: 2023-05-03T10:56:44Z
day: '06'
doi: 10.1002/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z
extern: '1'
external_id:
pmid:
- '10701441'
intvolume: ' 418'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 156 - 163
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4299'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Relationship between neurokinin-1 receptor and substance P in the striatum:
Light and electron microscopic immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 418
year: '2000'
...
---
_id: '2494'
abstract:
- lang: eng
text: 'This chapter focuses on metabotropic glutamate receptors (mGluRs). These
receptors are linked to several intracellular signal transduction mechanisms via
G-protein and are implicated in diverse functions of the mammalian central nervous
system (CNS). These functions include mediation of slow excitatory and inhibitory
responses; regulation of calcium channels, potassium channels, and non-selective
cation channels; inhibition and facilitation of transmitter release; induction
of long-term potentiation and long-term depression; and regulation of neuronal
development. Functional diversity of the metabotropic glutamate receptor is reflected
in molecular diversity of receptor subtypes. The sites of action of mGluRs are
widely found throughout different membrane compartments of neuronal and glial
cells. The chapter reviews the differential subcellular localization of metabotropic
glutamate receptors in relation to transmitter release sites. Patterns of subcellular
localization of mGluRs are different among three subgroups: group I and III mGluRs
are mainly localized to somatodendritic and axonal domains of neurons, respectively,
while group II mGluRs are extensively localized to both domains as well as to
glial cell processes.'
alternative_title:
- Handbook of Chemical Neuroanatomy
article_processing_charge: No
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical
and in situ hybridization analyses. In: Glutamate. Vol 18. Elsevier; 2000:63-98.
doi:10.1016/S0924-8196(00)80044-5'
apa: Shigemoto, R., & Mizuno, N. (2000). Chapter III Metabotropic glutamate
receptors - immunocytochemical and in situ hybridization analyses. In Glutamate
(Vol. 18, pp. 63–98). Elsevier. https://doi.org/10.1016/S0924-8196(00)80044-5
chicago: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In Glutamate,
18:63–98. Elsevier, 2000. https://doi.org/10.1016/S0924-8196(00)80044-5.
ieee: R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors
- immunocytochemical and in situ hybridization analyses,” in Glutamate,
vol. 18, Elsevier, 2000, pp. 63–98.
ista: 'Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors
- immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook
of Chemical Neuroanatomy, vol. 18, 63–98.'
mla: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
Receptors - Immunocytochemical and in Situ Hybridization Analyses.” Glutamate,
vol. 18, Elsevier, 2000, pp. 63–98, doi:10.1016/S0924-8196(00)80044-5.
short: R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.
date_created: 2018-12-11T11:58:00Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T12:27:40Z
day: '01'
doi: 10.1016/S0924-8196(00)80044-5
extern: '1'
intvolume: ' 18'
language:
- iso: eng
month: '01'
oa_version: None
page: 63 - 98
publication: Glutamate
publication_identifier:
eissn:
- 0924-8196
publication_status: published
publisher: Elsevier
publist_id: '4407'
quality_controlled: '1'
status: public
title: Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ
hybridization analyses
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '2000'
...
---
_id: '2418'
abstract:
- lang: eng
text: For an absolutely continuous probability measure μ on Rd and a nonnegative
integer k, let sk(μ, 0) denote the probability that the convex hull of k+d+1 random
points which are i.i.d. according to μ contains the origin 0. For d and k given,
we determine a tight upper bound on sk(μ, 0), and we characterize the measures
in Rd which attain this bound. This result can be considered a continuous analogue
of the Upper Bound Theorem for the maximal number of faces of convex polytopes
with a given number of vertices. For our proof we introduce so-called h-functions,
continuous counterparts of h-vectors for simplicial convex polytopes.
article_processing_charge: No
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: 'Wagner U, Welzl E. Origin-embracing distributions or a continuous analogue
of the Upper Bound Theorem. In: Proceedings of the 16th Annual Symposium on
Computational Geometry. ACM; 2000:50-56. doi:10.1145/336154.336176'
apa: 'Wagner, U., & Welzl, E. (2000). Origin-embracing distributions or a continuous
analogue of the Upper Bound Theorem. In Proceedings of the 16th annual symposium
on Computational geometry (pp. 50–56). Clear Water Bay Kowloon, Hong Kong:
ACM. https://doi.org/10.1145/336154.336176'
chicago: Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous
Analogue of the Upper Bound Theorem.” In Proceedings of the 16th Annual Symposium
on Computational Geometry, 50–56. ACM, 2000. https://doi.org/10.1145/336154.336176.
ieee: U. Wagner and E. Welzl, “Origin-embracing distributions or a continuous analogue
of the Upper Bound Theorem,” in Proceedings of the 16th annual symposium on
Computational geometry, Clear Water Bay Kowloon, Hong Kong, 2000, pp. 50–56.
ista: 'Wagner U, Welzl E. 2000. Origin-embracing distributions or a continuous analogue
of the Upper Bound Theorem. Proceedings of the 16th annual symposium on Computational
geometry. SCG: Symposium on Computational Geometry, 50–56.'
mla: Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous
Analogue of the Upper Bound Theorem.” Proceedings of the 16th Annual Symposium
on Computational Geometry, ACM, 2000, pp. 50–56, doi:10.1145/336154.336176.
short: U. Wagner, E. Welzl, in:, Proceedings of the 16th Annual Symposium on Computational
Geometry, ACM, 2000, pp. 50–56.
conference:
end_date: 2000-04-14
location: Clear Water Bay Kowloon, Hong Kong
name: 'SCG: Symposium on Computational Geometry'
start_date: 2000-06-12
date_created: 2018-12-11T11:57:33Z
date_published: 2000-05-01T00:00:00Z
date_updated: 2023-05-03T12:41:02Z
day: '01'
doi: 10.1145/336154.336176
extern: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 50 - 56
publication: Proceedings of the 16th annual symposium on Computational geometry
publication_identifier:
isbn:
- '9781581132243'
publication_status: published
publisher: ACM
publist_id: '4507'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Origin-embracing distributions or a continuous analogue of the Upper Bound
Theorem
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '2344'
abstract:
- lang: eng
text: The ground-state properties of interacting Bose gases in external potentials,
as considered in recent experiments, are usually described by means of the Gross-Pitaevskii
energy functional. We present here a rigorous proof of the asymptotic exactness
of this approximation for the ground-state energy and particle density of a dilute
Bose gas with a positive interaction.
article_processing_charge: No
article_type: original
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: 'Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of
the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular,
and Optical Physics. 2000;61(4):436021-4360213. doi:10.1103/PhysRevA.61.043602'
apa: 'Lieb, É., Seiringer, R., & Yngvason, J. (2000). Bosons in a trap: A rigorous
derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic,
Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.61.043602'
chicago: 'Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap:
A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical
Review A - Atomic, Molecular, and Optical Physics. American Physical Society,
2000. https://doi.org/10.1103/PhysRevA.61.043602.'
ieee: 'É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation
of the Gross-Pitaevskii energy functional,” Physical Review A - Atomic, Molecular,
and Optical Physics, vol. 61, no. 4. American Physical Society, pp. 436021–4360213,
2000.'
ista: 'Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation
of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular,
and Optical Physics. 61(4), 436021–4360213.'
mla: 'Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii
Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics,
vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:10.1103/PhysRevA.61.043602.'
short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular,
and Optical Physics 61 (2000) 436021–4360213.
date_created: 2018-12-11T11:57:07Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-03T12:47:08Z
day: '01'
doi: 10.1103/PhysRevA.61.043602
extern: '1'
external_id:
arxiv:
- math-ph/9908027
intvolume: ' 61'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/9908027
month: '04'
oa: 1
oa_version: Published Version
page: 436021 - 4360213
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_identifier:
issn:
- 0556-2791
publication_status: published
publisher: American Physical Society
publist_id: '4583'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '2000'
...
---
_id: '2342'
abstract:
- lang: eng
text: In the theoretical description of recent experiments with dilute Bose gases
confined in external potentials the Gross-Pitaevskii equation plays an important
role. Its status as an approximation for the quantum mechanical many-body ground
state problem has recently been rigorously clarified. A summary of this work is
presented here.
article_processing_charge: No
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: 'Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting
bosons in a trap. In: Proceedings of the International Symposium on Quantum
Theory and Symmetries. World Scientific Publishing; 2000:101-110.'
apa: Seiringer, R., Lieb, É., & Yngvason, J. (2000). The ground state energy
and density of interacting bosons in a trap. In Proceedings of the International
Symposium on Quantum Theory and Symmetries (pp. 101–110). World Scientific
Publishing.
chicago: Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State
Energy and Density of Interacting Bosons in a Trap.” In Proceedings of the
International Symposium on Quantum Theory and Symmetries, 101–10. World Scientific
Publishing, 2000.
ieee: R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density
of interacting bosons in a trap,” in Proceedings of the International Symposium
on Quantum Theory and Symmetries, 2000, pp. 101–110.
ista: 'Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density
of interacting bosons in a trap. Proceedings of the International Symposium on
Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.'
mla: Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting
Bosons in a Trap.” Proceedings of the International Symposium on Quantum Theory
and Symmetries, World Scientific Publishing, 2000, pp. 101–10.
short: R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International
Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000,
pp. 101–110.
conference:
name: 'ISQTS: Quantum Theory and Symmetries'
date_created: 2018-12-11T11:57:06Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-03T13:00:35Z
day: '01'
extern: '1'
external_id:
arxiv:
- math-ph/9911026
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/9911026
month: '06'
oa: 1
oa_version: None
page: 101 - 110
publication: Proceedings of the International Symposium on Quantum Theory and Symmetries
publication_identifier:
isbn:
- '9789810242374 '
publication_status: published
publisher: World Scientific Publishing
publist_id: '4584'
quality_controlled: '1'
status: public
title: The ground state energy and density of interacting bosons in a trap
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '1957'
abstract:
- lang: eng
text: NADH:ubiquinone oxidoreductase (complex I) is the first and largest enzyme
of the mitochondrial respiratory chain. The low-resolution structure of the complex
is known from electron microscopy studies. The general shape of the complex is
in the form of an L, with one arm in the membrane and the other peripheral. We
have purified complex I from beef heart mitochondria and reconstituted the enzyme
into lipid bilayers. Under different conditions, several two-dimensional crystal
forms were obtained. Crystals belonging to space groups p2221 and c12 (unit cell
488 Å x 79 Å) were obtained at 22°C and contained only the membrane fragment of
complex I similar to hydrophobic subcomplex Iβ but lacking the ND5 subunit. A
crystal form with larger unit cell (534 Å x 81 Å, space group c12) produced at
4°C contained both the peripheral and membrane arms of the enzyme, except that
ND5 was missing. Projection maps from frozen hydrated samples were calculated
for all crystal forms. By comparing two different c12 crystal forms, extra electron
density in the projection map of large crystal form was assigned to the peripheral
arm of the enzyme. One of the features of the map is a deep, channel-like, cleft
next to peripheral arm. Comparison with available structures of the intact enzyme
indicates that large hydrophobic subunit ND5 is situated at the distal end of
the membrane domain. Possible locations of sub-unit ND4 and of other subunits
in the membrane domain are proposed. Implications of our findings for the mechanism
of proton pumping by complex I are discussed. (C) 2000 Academic Press.
acknowledgement: We thank Drs I. M. Fearnley and S. Y. Peak-Chew for performing peptide
mass mapping. We also thank Drs R. Henderson and G. F. X. Schertler for advice on
image processing and for valuable discussions.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: John
full_name: Walker, John
last_name: Walker
citation:
ama: Sazanov LA, Walker J. Cryo-electron crystallography of two sub-complexes of
bovine complex I reveals the relationship between the membrane and peripheral
arms. Journal of Molecular Biology. 2000;302(2):455-464. doi:10.1006/jmbi.2000.4079
apa: Sazanov, L. A., & Walker, J. (2000). Cryo-electron crystallography of two
sub-complexes of bovine complex I reveals the relationship between the membrane
and peripheral arms. Journal of Molecular Biology. Elsevier. https://doi.org/10.1006/jmbi.2000.4079
chicago: Sazanov, Leonid A, and John Walker. “Cryo-Electron Crystallography of Two
Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane
and Peripheral Arms.” Journal of Molecular Biology. Elsevier, 2000. https://doi.org/10.1006/jmbi.2000.4079.
ieee: L. A. Sazanov and J. Walker, “Cryo-electron crystallography of two sub-complexes
of bovine complex I reveals the relationship between the membrane and peripheral
arms,” Journal of Molecular Biology, vol. 302, no. 2. Elsevier, pp. 455–464,
2000.
ista: Sazanov LA, Walker J. 2000. Cryo-electron crystallography of two sub-complexes
of bovine complex I reveals the relationship between the membrane and peripheral
arms. Journal of Molecular Biology. 302(2), 455–464.
mla: Sazanov, Leonid A., and John Walker. “Cryo-Electron Crystallography of Two
Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane
and Peripheral Arms.” Journal of Molecular Biology, vol. 302, no. 2, Elsevier,
2000, pp. 455–64, doi:10.1006/jmbi.2000.4079.
short: L.A. Sazanov, J. Walker, Journal of Molecular Biology 302 (2000) 455–464.
date_created: 2018-12-11T11:54:55Z
date_published: 2000-09-15T00:00:00Z
date_updated: 2023-05-04T13:23:03Z
day: '15'
doi: 10.1006/jmbi.2000.4079
extern: '1'
external_id:
pmid:
- '10970745'
intvolume: ' 302'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 455 - 464
pmid: 1
publication: Journal of Molecular Biology
publication_identifier:
issn:
- 0022-2836
publication_status: published
publisher: Elsevier
publist_id: '5126'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cryo-electron crystallography of two sub-complexes of bovine complex I reveals
the relationship between the membrane and peripheral arms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 302
year: '2000'
...
---
_id: '1736'
abstract:
- lang: eng
text: A coding scheme called diode is compared with duobinary signalling and with
normal binary transmission. It is shown that the diode coding suppresses the FWM
products of a three channel DWDM system and this reduction against that achieved
with duobinary coding is presented. The results presented show how the average
level of the FWM products relative to the average levels of the three optical
carriers vary over the channel spacing range. The suppression observed is about
/ dB more than that achieved with duobinary modulation and is greater for narrow
channel spacing.
alternative_title:
- LEOS
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Phil
full_name: Lane, Phil
last_name: Lane
- first_name: Michelle
full_name: Murphy, Michelle
last_name: Murphy
citation:
ama: 'Katsaros G, Lane P, Murphy M. Comparison of the impact of FWM on binary, duobinary
and dicode modulation in DWDM systems. In: Proceedings of the 2000 IEEE Annual
Meeting Conference . Vol 1. IEEE; 2000:27-28. doi:10.1109/LEOS.2000.890656'
apa: 'Katsaros, G., Lane, P., & Murphy, M. (2000). Comparison of the impact
of FWM on binary, duobinary and dicode modulation in DWDM systems. In Proceedings
of the 2000 IEEE Annual Meeting Conference (Vol. 1, pp. 27–28). Rio Grande,
PR, USA: IEEE. https://doi.org/10.1109/LEOS.2000.890656'
chicago: Katsaros, Georgios, Phil Lane, and Michelle Murphy. “Comparison of the
Impact of FWM on Binary, Duobinary and Dicode Modulation in DWDM Systems.” In
Proceedings of the 2000 IEEE Annual Meeting Conference , 1:27–28. IEEE,
2000. https://doi.org/10.1109/LEOS.2000.890656.
ieee: G. Katsaros, P. Lane, and M. Murphy, “Comparison of the impact of FWM on binary,
duobinary and dicode modulation in DWDM systems,” in Proceedings of the 2000
IEEE Annual Meeting Conference , Rio Grande, PR, USA, 2000, vol. 1, pp. 27–28.
ista: Katsaros G, Lane P, Murphy M. 2000. Comparison of the impact of FWM on binary,
duobinary and dicode modulation in DWDM systems. Proceedings of the 2000 IEEE
Annual Meeting Conference . Lasers and Electro Optics Society Annual Meeting,
LEOS, vol. 1, 27–28.
mla: Katsaros, Georgios, et al. “Comparison of the Impact of FWM on Binary, Duobinary
and Dicode Modulation in DWDM Systems.” Proceedings of the 2000 IEEE Annual
Meeting Conference , vol. 1, IEEE, 2000, pp. 27–28, doi:10.1109/LEOS.2000.890656.
short: G. Katsaros, P. Lane, M. Murphy, in:, Proceedings of the 2000 IEEE Annual
Meeting Conference , IEEE, 2000, pp. 27–28.
conference:
end_date: 2000-11-16
location: Rio Grande, PR, USA
name: Lasers and Electro Optics Society Annual Meeting
start_date: 2000-11-13
date_created: 2018-12-11T11:53:44Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-04T14:46:21Z
day: '01'
doi: 10.1109/LEOS.2000.890656
extern: '1'
intvolume: ' 1'
language:
- iso: eng
month: '01'
oa_version: None
page: 27 - 28
publication: 'Proceedings of the 2000 IEEE Annual Meeting Conference '
publication_identifier:
isbn:
- 078035947X
publication_status: published
publisher: IEEE
publist_id: '5388'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the impact of FWM on binary, duobinary and dicode modulation
in DWDM systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '2000'
...
---
_id: '1958'
abstract:
- lang: eng
text: "\r\nComplex I (NADH:ubiquinone oxidoreductase) purified from bovine heart
mitochondria was treated with the detergent N,N-dimethyldodecylamine N-oxide (LDAO).
The enzyme dissociated into two known subcomplexes, Iα and Iβ, containing mostly
hydrophilic and hydrophobic subunits, and a previously undetected fragment referred
to as Iγ. Subcomplex Iγ contains the hydrophobic subunits ND1, ND2, ND3, and ND4L
which are encoded in the mitochondrial genome, and the nuclear-encoded subunit
KFYL. During size- exclusion chromatography in the presence of LDAO, subcomplex
Iα lost several subunits and formed another characterized subcomplex known as
Iλ. Similarly, subcomplex Iβ dissociated into two smaller subcomplexes, one of
which contains the hydrophobic subunits ND4 and ND5; subcomplex Iγ released a
fragment containing ND1 and ND2. These results suggest that in the intact complex
subunits ND1 and ND2 are likely to be in a different region of the membrane domain
than subunits ND4 and ND5. The compositions of the various subcomplexes and fragments
of complex I provide an organization of the subunits of the enzyme in the framework
of the known low resolution structure of the enzyme."
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Sew
full_name: Peak Chew, Sew
last_name: Peak Chew
- first_name: Ian
full_name: Fearnley, Ian
last_name: Fearnley
- first_name: John
full_name: Walker, John
last_name: Walker
citation:
ama: 'Sazanov LA, Peak Chew S, Fearnley I, Walker J. Resolution of the membrane
domain of bovine complex I into subcomplexes: implications for the structural
organization of the enzyme. Biochemistry. 2000;39(24):7229-7235. doi:10.1021/bi000335t'
apa: 'Sazanov, L. A., Peak Chew, S., Fearnley, I., & Walker, J. (2000). Resolution
of the membrane domain of bovine complex I into subcomplexes: implications for
the structural organization of the enzyme. Biochemistry. ACS. https://doi.org/10.1021/bi000335t'
chicago: 'Sazanov, Leonid A, Sew Peak Chew, Ian Fearnley, and John Walker. “Resolution
of the Membrane Domain of Bovine Complex I into Subcomplexes: Implications for
the Structural Organization of the Enzyme.” Biochemistry. ACS, 2000. https://doi.org/10.1021/bi000335t.'
ieee: 'L. A. Sazanov, S. Peak Chew, I. Fearnley, and J. Walker, “Resolution of the
membrane domain of bovine complex I into subcomplexes: implications for the structural
organization of the enzyme,” Biochemistry, vol. 39, no. 24. ACS, pp. 7229–7235,
2000.'
ista: 'Sazanov LA, Peak Chew S, Fearnley I, Walker J. 2000. Resolution of the membrane
domain of bovine complex I into subcomplexes: implications for the structural
organization of the enzyme. Biochemistry. 39(24), 7229–7235.'
mla: 'Sazanov, Leonid A., et al. “Resolution of the Membrane Domain of Bovine Complex
I into Subcomplexes: Implications for the Structural Organization of the Enzyme.”
Biochemistry, vol. 39, no. 24, ACS, 2000, pp. 7229–35, doi:10.1021/bi000335t.'
short: L.A. Sazanov, S. Peak Chew, I. Fearnley, J. Walker, Biochemistry 39 (2000)
7229–7235.
date_created: 2018-12-11T11:54:55Z
date_published: 2000-05-24T00:00:00Z
date_updated: 2023-05-04T14:14:53Z
day: '24'
doi: 10.1021/bi000335t
extern: '1'
external_id:
pmid:
- '10852722'
intvolume: ' 39'
issue: '24'
language:
- iso: eng
month: '05'
oa_version: None
page: 7229 - 7235
pmid: 1
publication: Biochemistry
publication_identifier:
issn:
- 0006-2960
publication_status: published
publisher: ACS
publist_id: '5127'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Resolution of the membrane domain of bovine complex I into subcomplexes: implications
for the structural organization of the enzyme'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 39
year: '2000'
...
---
_id: '12925'
abstract:
- lang: eng
text: Normal function of organs and cells is tightly linked to the cytoarchitecture.
Control of the cell volume is therefore vital for the organism. A widely established
strategy of cells to counteract swelling is the activation of chloride and potassium
channels, which leads to a net efflux of salt followed by water - a process termed
regulatory volume decrease. Since there is evidence for swelling-dependent chloride
channels (IClswell) being activated also during pathological processes, the identification
of the molecular entity underlying IClswell is of utmost importance. Several proteins
are discussed as the channel forming IClswell, i.e. phospholemman, p-glycoprotein,
CLC-3 and ICln. In this review we would like to focus on the properties of ICln,
a protein cloned from a Madin Darby canine kidney (MDCK) cell library whose expression
in Xenopus laevis oocytes resulted in a nucleotide sensitive outwardly rectifying
chloride current closely resembling the biophysical properties of IClswell.
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
full_name: Fürst, Johannes
last_name: Fürst
- first_name: Martin
full_name: Jakab, Martin
last_name: Jakab
- first_name: Matthias
full_name: König, Matthias
last_name: König
- first_name: Markus
full_name: Ritter, Markus
last_name: Ritter
- first_name: Martin
full_name: Gschwentner, Martin
last_name: Gschwentner
- first_name: Jakob
full_name: Rudzki, Jakob
last_name: Rudzki
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Michael
full_name: Mayer, Michael
last_name: Mayer
- first_name: Carmen M.
full_name: Burtscher, Carmen M.
last_name: Burtscher
- first_name: Julia
full_name: Schirmer, Julia
last_name: Schirmer
- first_name: Brigitte
full_name: Maier, Brigitte
last_name: Maier
- first_name: Manfred
full_name: Nairz, Manfred
last_name: Nairz
- first_name: Sabine
full_name: Chwatal, Sabine
last_name: Chwatal
- first_name: Markus
full_name: Paulmichl, Markus
last_name: Paulmichl
citation:
ama: Fürst J, Jakab M, König M, et al. Structure and Function of the Ion Channel
ICln. Cellular Physiology and Biochemistry. 2000;10(5-6):329-334. doi:10.1159/000016374
apa: Fürst, J., Jakab, M., König, M., Ritter, M., Gschwentner, M., Rudzki, J., …
Paulmichl, M. (2000). Structure and Function of the Ion Channel ICln. Cellular
Physiology and Biochemistry. S. Karger AG. https://doi.org/10.1159/000016374
chicago: Fürst, Johannes, Martin Jakab, Matthias König, Markus Ritter, Martin Gschwentner,
Jakob Rudzki, Johann G Danzl, et al. “Structure and Function of the Ion Channel
ICln.” Cellular Physiology and Biochemistry. S. Karger AG, 2000. https://doi.org/10.1159/000016374.
ieee: J. Fürst et al., “Structure and Function of the Ion Channel ICln,”
Cellular Physiology and Biochemistry, vol. 10, no. 5–6. S. Karger AG, pp.
329–334, 2000.
ista: Fürst J, Jakab M, König M, Ritter M, Gschwentner M, Rudzki J, Danzl JG, Mayer
M, Burtscher CM, Schirmer J, Maier B, Nairz M, Chwatal S, Paulmichl M. 2000. Structure
and Function of the Ion Channel ICln. Cellular Physiology and Biochemistry. 10(5–6),
329–334.
mla: Fürst, Johannes, et al. “Structure and Function of the Ion Channel ICln.” Cellular
Physiology and Biochemistry, vol. 10, no. 5–6, S. Karger AG, 2000, pp. 329–34,
doi:10.1159/000016374.
short: J. Fürst, M. Jakab, M. König, M. Ritter, M. Gschwentner, J. Rudzki, J.G.
Danzl, M. Mayer, C.M. Burtscher, J. Schirmer, B. Maier, M. Nairz, S. Chwatal,
M. Paulmichl, Cellular Physiology and Biochemistry 10 (2000) 329–334.
date_created: 2023-05-08T09:04:58Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-08T10:07:10Z
doi: 10.1159/000016374
extern: '1'
external_id:
pmid:
- '11125213'
intvolume: ' 10'
issue: 5-6
keyword:
- Physiology
language:
- iso: eng
oa_version: None
page: 329-334
pmid: 1
publication: Cellular Physiology and Biochemistry
publication_identifier:
issn:
- 1015-8987
- 1421-9778
publication_status: published
publisher: S. Karger AG
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure and Function of the Ion Channel ICln
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2000'
...
---
_id: '1455'
abstract:
- lang: eng
text: First, a special case of Knaster's problem is proved implying that each symmetric
convex body in ℝ3 admits an inscribed cube. It is deduced from a theorem in equivariant
topology, which says that there is no S4 - equivariant map from SO(3) to S2, where
S4 acts on SO(3) on the right as the rotation group of the cube, and on S2 on
the right as the symmetry group of the regular tetrahedron. Some generalizations
are also given. Second, it is shown how the above non-existence theorem yields
Makeev's conjecture in ℝ3 that each set in ℝ3 of diameter 1 can be covered by
a rhombic dodecahedron, which has distance 1 between its opposite faces. This
reveals an unexpected connection between inscribing cubes into symmetric bodies
and covering sets by rhombic dodecahedra. Finally, a possible application of our
second theorem to the Borsuk problem in ℝ3 is pointed out.
acknowledgement: The research of the first author was partially supported by Trinity
College, Cambridge, and that of all the authors by grants 23444, T-030012 and A
046/96, respectively, from the Hungarian National Foundation for Scientific Research.
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Endre
full_name: Makai, Endre
last_name: Makai
- first_name: András
full_name: Szücs, András
last_name: Szücs
citation:
ama: Hausel T, Makai E, Szücs A. Inscribing cubes and covering by rhombic dodecahedra
via equivariant topology. Mathematika. 2000;47(1-2):371-397. doi:10.1112/S0025579300015965
apa: Hausel, T., Makai, E., & Szücs, A. (2000). Inscribing cubes and covering
by rhombic dodecahedra via equivariant topology. Mathematika. University
College London. https://doi.org/10.1112/S0025579300015965
chicago: Hausel, Tamás, Endre Makai, and András Szücs. “Inscribing Cubes and Covering
by Rhombic Dodecahedra via Equivariant Topology.” Mathematika. University
College London, 2000. https://doi.org/10.1112/S0025579300015965.
ieee: T. Hausel, E. Makai, and A. Szücs, “Inscribing cubes and covering by rhombic
dodecahedra via equivariant topology,” Mathematika, vol. 47, no. 1–2. University
College London, pp. 371–397, 2000.
ista: Hausel T, Makai E, Szücs A. 2000. Inscribing cubes and covering by rhombic
dodecahedra via equivariant topology. Mathematika. 47(1–2), 371–397.
mla: Hausel, Tamás, et al. “Inscribing Cubes and Covering by Rhombic Dodecahedra
via Equivariant Topology.” Mathematika, vol. 47, no. 1–2, University College
London, 2000, pp. 371–97, doi:10.1112/S0025579300015965.
short: T. Hausel, E. Makai, A. Szücs, Mathematika 47 (2000) 371–397.
date_created: 2018-12-11T11:52:07Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-08T08:56:46Z
day: '01'
doi: 10.1112/S0025579300015965
extern: '1'
external_id:
arxiv:
- math/9906066
intvolume: ' 47'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/9906066
month: '06'
oa: 1
oa_version: Preprint
page: 371 - 397
publication: Mathematika
publication_identifier:
issn:
- 0025-5793
publication_status: published
publisher: University College London
publist_id: '5745'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inscribing cubes and covering by rhombic dodecahedra via equivariant topology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '2000'
...
---
_id: '842'
article_processing_charge: No
article_type: original
author:
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Wolf Y, Kondrashov F, Koonin E. No footprints of primordial introns in a eukaryotic
genome. Trends in Genetics. 2000;16(8):333-334. doi:10.1016/S0168-9525(00)02059-X
apa: Wolf, Y., Kondrashov, F., & Koonin, E. (2000). No footprints of primordial
introns in a eukaryotic genome. Trends in Genetics. Elsevier. https://doi.org/10.1016/S0168-9525(00)02059-X
chicago: Wolf, Yuri, Fyodor Kondrashov, and Eugene Koonin. “No Footprints of Primordial
Introns in a Eukaryotic Genome.” Trends in Genetics. Elsevier, 2000. https://doi.org/10.1016/S0168-9525(00)02059-X.
ieee: Y. Wolf, F. Kondrashov, and E. Koonin, “No footprints of primordial introns
in a eukaryotic genome,” Trends in Genetics, vol. 16, no. 8. Elsevier,
pp. 333–334, 2000.
ista: Wolf Y, Kondrashov F, Koonin E. 2000. No footprints of primordial introns
in a eukaryotic genome. Trends in Genetics. 16(8), 333–334.
mla: Wolf, Yuri, et al. “No Footprints of Primordial Introns in a Eukaryotic Genome.”
Trends in Genetics, vol. 16, no. 8, Elsevier, 2000, pp. 333–34, doi:10.1016/S0168-9525(00)02059-X.
short: Y. Wolf, F. Kondrashov, E. Koonin, Trends in Genetics 16 (2000) 333–334.
date_created: 2018-12-11T11:48:48Z
date_published: 2000-08-01T00:00:00Z
date_updated: 2023-05-08T09:22:03Z
day: '01'
doi: 10.1016/S0168-9525(00)02059-X
extern: '1'
external_id:
pmid:
- '10904260 '
intvolume: ' 16'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 333 - 334
pmid: 1
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9479
publication_status: published
publisher: Elsevier
publist_id: '6806'
quality_controlled: '1'
scopus_import: '1'
status: public
title: No footprints of primordial introns in a eukaryotic genome
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2000'
...
---
_id: '13437'
abstract:
- lang: eng
text: Liquid/liquid Phase Transfer Catalysis (PTC) reaction of 4-chlorobutyronitrile
with nonenolisable aldehydes leads via an addition-cyclisation reaction sequence
to derivatives of tetrahydrofuran-3-carbonitrile.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Mieczysław
full_name: Macogonkosza, Mieczysław
last_name: Macogonkosza
- first_name: Jacek
full_name: Przyborowski, Jacek
last_name: Przyborowski
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Andrzej
full_name: Kwast, Andrzej
last_name: Kwast
citation:
ama: Macogonkosza M, Przyborowski J, Klajn R, Kwast A. Simple synthesis of 2-substituted
Tetrahydrofuran-3-carbonitriles. Synlett. 2000;2000(12):1773-1774. doi:10.1055/s-2000-8670
apa: Macogonkosza, M., Przyborowski, J., Klajn, R., & Kwast, A. (2000). Simple
synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles. Synlett. Georg
Thieme Verlag. https://doi.org/10.1055/s-2000-8670
chicago: Macogonkosza, Mieczysław, Jacek Przyborowski, Rafal Klajn, and Andrzej
Kwast. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.” Synlett.
Georg Thieme Verlag, 2000. https://doi.org/10.1055/s-2000-8670.
ieee: M. Macogonkosza, J. Przyborowski, R. Klajn, and A. Kwast, “Simple synthesis
of 2-substituted Tetrahydrofuran-3-carbonitriles,” Synlett, vol. 2000,
no. 12. Georg Thieme Verlag, pp. 1773–1774, 2000.
ista: Macogonkosza M, Przyborowski J, Klajn R, Kwast A. 2000. Simple synthesis of
2-substituted Tetrahydrofuran-3-carbonitriles. Synlett. 2000(12), 1773–1774.
mla: Macogonkosza, Mieczysław, et al. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.”
Synlett, vol. 2000, no. 12, Georg Thieme Verlag, 2000, pp. 1773–74, doi:10.1055/s-2000-8670.
short: M. Macogonkosza, J. Przyborowski, R. Klajn, A. Kwast, Synlett 2000 (2000)
1773–1774.
date_created: 2023-08-01T10:39:48Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-08-02T07:54:46Z
day: '01'
doi: 10.1055/s-2000-8670
extern: '1'
intvolume: ' 2000'
issue: '12'
keyword:
- Organic Chemistry
language:
- iso: eng
month: '12'
oa_version: None
page: 1773-1774
publication: Synlett
publication_identifier:
eissn:
- 1437-2096
issn:
- 0936-5214
publication_status: published
publisher: Georg Thieme Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2000
year: '2000'
...