[{"citation":{"ista":"Agarwal PK, EppsteinL. J. Guibas D, Henzinger MH. 1998. Parametric and kinetic minimum spanning trees. Proceedings of the 39th Annual Symposium on Foundations of Computer Science. Annual IEEE Symposium on Foundations of Computer Science, 596–605.","chicago":"Agarwal, P. K., D. EppsteinL. J. Guibas, and Monika H Henzinger. “Parametric and Kinetic Minimum Spanning Trees.” In Proceedings of the 39th Annual Symposium on Foundations of Computer Science, 596–605, 1998. https://doi.org/10.1109/SFCS.1998.743510.","ama":"Agarwal PK, EppsteinL. J. Guibas D, Henzinger MH. Parametric and kinetic minimum spanning trees. In: Proceedings of the 39th Annual Symposium on Foundations of Computer Science. ; 1998:596-605. doi:10.1109/SFCS.1998.743510","apa":"Agarwal, P. K., EppsteinL. J. Guibas, D., & Henzinger, M. H. (1998). Parametric and kinetic minimum spanning trees. In Proceedings of the 39th Annual Symposium on Foundations of Computer Science (pp. 596–605). Palo Alto, CA, United States. https://doi.org/10.1109/SFCS.1998.743510","short":"P.K. Agarwal, D. EppsteinL. J. Guibas, M.H. Henzinger, in:, Proceedings of the 39th Annual Symposium on Foundations of Computer Science, 1998, pp. 596–605.","ieee":"P. K. Agarwal, D. EppsteinL. J. Guibas, and M. H. Henzinger, “Parametric and kinetic minimum spanning trees,” in Proceedings of the 39th Annual Symposium on Foundations of Computer Science, Palo Alto, CA, United States, 1998, pp. 596–605.","mla":"Agarwal, P. K., et al. “Parametric and Kinetic Minimum Spanning Trees.” Proceedings of the 39th Annual Symposium on Foundations of Computer Science, 1998, pp. 596–605, doi:10.1109/SFCS.1998.743510."},"date_updated":"2023-02-09T11:28:52Z","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Agarwal","full_name":"Agarwal, P. K.","first_name":"P. K."},{"first_name":"D.","last_name":"EppsteinL. J. Guibas","full_name":"EppsteinL. J. Guibas, D."},{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"article_processing_charge":"No","title":"Parametric and kinetic minimum spanning trees","_id":"11682","type":"conference","conference":{"name":"Annual IEEE Symposium on Foundations of Computer Science","location":"Palo Alto, CA, United States","end_date":"1998-11-11","start_date":"1998-11-08"},"status":"public","publication_identifier":{"issn":["0272-5428"],"isbn":["0-8186-9172-7"]},"publication_status":"published","year":"1998","day":"01","language":[{"iso":"eng"}],"publication":"Proceedings of the 39th Annual Symposium on Foundations of Computer Science","page":"596-605","doi":"10.1109/SFCS.1998.743510","date_published":"1998-09-01T00:00:00Z","date_created":"2022-07-28T07:21:34Z","abstract":[{"lang":"eng","text":"We consider the parametric minimum spanning tree problem, in which we are given a graph with edge weights that are linear functions of a parameter /spl lambda/ and wish to compute the sequence of minimum spanning trees generated as /spl lambda/ varies. We also consider the kinetic minimum spanning tree problem, in which /spl lambda/ represents time and the graph is subject in addition to changes such as edge insertions, deletions, and modifications of the weight functions as time progresses. We solve both problems in time O(n/sup 2/3/log/sup 4/3/) per combinatorial change in the tree (or randomized O(n/sup 2/3/log/sup 4/3/ n) per change). Our time bounds reduce to O(n/sup 1/2/log/sup 3/2/ n) per change (O(n/sup 1/2/log n) randomized) for planar graphs or other minor-closed families of graphs, and O(n/sup 1/4/log/sup 3/2/ n) per change (O(n/sup 1/4/ log n) randomized) for planar graphs with weight changes but no insertions or deletions."}],"oa_version":"None","quality_controlled":"1","scopus_import":"1","month":"09"},{"article_processing_charge":"No","author":[{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger"},{"last_name":"Fredman","full_name":"Fredman, M. L.","first_name":"M. L."}],"title":"Lower bounds for fully dynamic connectivity problems in graphs","citation":{"ieee":"M. H. Henzinger and M. L. Fredman, “Lower bounds for fully dynamic connectivity problems in graphs,” Algorithmica, vol. 22, no. 3. Springer Nature, pp. 351–362, 1998.","short":"M.H. Henzinger, M.L. Fredman, Algorithmica 22 (1998) 351–362.","ama":"Henzinger MH, Fredman ML. Lower bounds for fully dynamic connectivity problems in graphs. Algorithmica. 1998;22(3):351-362. doi:10.1007/pl00009228","apa":"Henzinger, M. H., & Fredman, M. L. (1998). Lower bounds for fully dynamic connectivity problems in graphs. Algorithmica. Springer Nature. https://doi.org/10.1007/pl00009228","mla":"Henzinger, Monika H., and M. L. Fredman. “Lower Bounds for Fully Dynamic Connectivity Problems in Graphs.” Algorithmica, vol. 22, no. 3, Springer Nature, 1998, pp. 351–62, doi:10.1007/pl00009228.","ista":"Henzinger MH, Fredman ML. 1998. Lower bounds for fully dynamic connectivity problems in graphs. Algorithmica. 22(3), 351–362.","chicago":"Henzinger, Monika H, and M. L. Fredman. “Lower Bounds for Fully Dynamic Connectivity Problems in Graphs.” Algorithmica. Springer Nature, 1998. https://doi.org/10.1007/pl00009228."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"351-362","date_created":"2022-07-28T06:58:36Z","doi":"10.1007/pl00009228","date_published":"1998-11-01T00:00:00Z","year":"1998","publication":"Algorithmica","day":"01","quality_controlled":"1","publisher":"Springer Nature","acknowledgement":".","date_updated":"2022-09-12T09:03:36Z","extern":"1","article_type":"original","type":"journal_article","keyword":["Dynamic planarity testing","Dynamic connectivity testing","Lower bounds","Cell probe model"],"status":"public","_id":"11681","volume":22,"issue":"3","publication_status":"published","publication_identifier":{"eissn":["1432-0541"],"issn":["0178-4617"]},"language":[{"iso":"eng"}],"scopus_import":"1","intvolume":" 22","month":"11","abstract":[{"lang":"eng","text":"We prove lower bounds on the complexity of maintaining fully dynamic k -edge or k -vertex connectivity in plane graphs and in (k-1) -vertex connected graphs. We show an amortized lower bound of Ω (log n / {k (log log n} + log b)) per edge insertion, deletion, or query operation in the cell probe model, where b is the word size of the machine and n is the number of vertices in G . We also show an amortized lower bound of Ω (log n /(log log n + log b)) per operation for fully dynamic planarity testing in embedded graphs. These are the first lower bounds for fully dynamic connectivity problems."}],"oa_version":"None"},{"publication":"9th Annual ACM SIAM Symposium on Discrete Algorithms","language":[{"iso":"eng"}],"day":"01","publication_status":"published","year":"1998","publication_identifier":{"isbn":["0898714109"]},"date_created":"2022-08-19T06:22:30Z","date_published":"1998-01-01T00:00:00Z","related_material":{"record":[{"relation":"later_version","id":"11763","status":"public"}]},"page":"97-106","oa_version":"None","abstract":[{"lang":"eng","text":"We present the first polylog-competitive online algorithm for the general multicast problem in the throughput model. The ratio of the number of requests accepted by the optimum offline alaorithm to the exoected number of reauests accepted by our algorithm is O(jlog n + log log M)(log n + log M) log n), where M is the number of multicast groups and n is the number of nodes in the nraoh. We show that this is close to optimum by presenting-an*R(log nlog M) lower\r\nbound on this ratio for anv randomized online algorithm against an oblivious adversary, when M is much lar&r than the link capacities. Our lower bound applies even in the restricted case where the link capacities are much larger than bandwidth requested by a single multicast. We also present a simple proof showing that it is impossible to be competitive against an adaptive online adversary. As in the previous online routing algorithms, our algorithm uses edge-costs when deciding on which is the best path to use. In contrast to the nrevious comnetitive aleorithms in the throughput modei, our cost is-not a direct function of the edne load. The new cost definition allows us to decouple the effects of routing and admission decisions of different multicast groups. "}],"month":"01","scopus_import":"1","quality_controlled":"1","publisher":"Society for Industrial and Applied Mathematics","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","citation":{"mla":"Goel, Ashish, et al. “An Online Throughput-Competitive Algorithm for Multicast Routing and Admission Control.” 9th Annual ACM SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 1998, pp. 97–106.","ieee":"A. Goel, M. H. Henzinger, and S. Plotkin, “An online throughput-competitive algorithm for multicast routing and admission control,” in 9th Annual ACM SIAM Symposium on Discrete Algorithms, San Francisco, CA, United States, 1998, pp. 97–106.","short":"A. Goel, M.H. Henzinger, S. Plotkin, in:, 9th Annual ACM SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 1998, pp. 97–106.","ama":"Goel A, Henzinger MH, Plotkin S. An online throughput-competitive algorithm for multicast routing and admission control. In: 9th Annual ACM SIAM Symposium on Discrete Algorithms. Society for Industrial and Applied Mathematics; 1998:97-106.","apa":"Goel, A., Henzinger, M. H., & Plotkin, S. (1998). An online throughput-competitive algorithm for multicast routing and admission control. In 9th Annual ACM SIAM Symposium on Discrete Algorithms (pp. 97–106). San Francisco, CA, United States: Society for Industrial and Applied Mathematics.","chicago":"Goel, Ashish, Monika H Henzinger, and Serge Plotkin. “An Online Throughput-Competitive Algorithm for Multicast Routing and Admission Control.” In 9th Annual ACM SIAM Symposium on Discrete Algorithms, 97–106. Society for Industrial and Applied Mathematics, 1998.","ista":"Goel A, Henzinger MH, Plotkin S. 1998. An online throughput-competitive algorithm for multicast routing and admission control. 9th Annual ACM SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 97–106."},"date_updated":"2023-02-21T16:27:22Z","title":"An online throughput-competitive algorithm for multicast routing and admission control","article_processing_charge":"No","author":[{"first_name":"Ashish","last_name":"Goel","full_name":"Goel, Ashish"},{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"last_name":"Plotkin","full_name":"Plotkin, Serge","first_name":"Serge"}],"_id":"11926","status":"public","conference":{"start_date":"1998-01-25","end_date":"1998-01-27","location":"San Francisco, CA, United States","name":"SODA: Symposium on Discrete Algorithms"},"type":"conference"},{"year":"1998","publication":"Algorithmica","day":"01","page":"31-60","date_created":"2022-07-28T06:50:51Z","date_published":"1998-01-01T00:00:00Z","doi":"10.1007/pl00009186","acknowledgement":"The authors would like to thank Emo Welzl for helpful discussions.","quality_controlled":"1","publisher":"Springer Nature","citation":{"mla":"Alberts, D., and Monika H. Henzinger. “Average-Case Analysis of Dynamic Graph Algorithms.” Algorithmica, vol. 20, Springer Nature, 1998, pp. 31–60, doi:10.1007/pl00009186.","short":"D. Alberts, M.H. Henzinger, Algorithmica 20 (1998) 31–60.","ieee":"D. Alberts and M. H. Henzinger, “Average-case analysis of dynamic graph algorithms,” Algorithmica, vol. 20. Springer Nature, pp. 31–60, 1998.","ama":"Alberts D, Henzinger MH. Average-case analysis of dynamic graph algorithms. Algorithmica. 1998;20:31-60. doi:10.1007/pl00009186","apa":"Alberts, D., & Henzinger, M. H. (1998). Average-case analysis of dynamic graph algorithms. Algorithmica. Springer Nature. https://doi.org/10.1007/pl00009186","chicago":"Alberts, D., and Monika H Henzinger. “Average-Case Analysis of Dynamic Graph Algorithms.” Algorithmica. Springer Nature, 1998. https://doi.org/10.1007/pl00009186.","ista":"Alberts D, Henzinger MH. 1998. Average-case analysis of dynamic graph algorithms. Algorithmica. 20, 31–60."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","author":[{"first_name":"D.","full_name":"Alberts, D.","last_name":"Alberts"},{"first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530"}],"title":"Average-case analysis of dynamic graph algorithms","publication_status":"published","publication_identifier":{"eissn":["1432-0541"],"issn":["0178-4617"]},"language":[{"iso":"eng"}],"volume":20,"related_material":{"record":[{"relation":"earlier_version","status":"public","id":"11928"}]},"abstract":[{"text":"We present a model for edge updates with restricted randomness in dynamic graph algorithms and a general technique for analyzing the expected running time of an update operation. This model is able to capture the average case in many applications, since (1) it allows restrictions on the set of edges which can be used for insertions and (2) the type (insertion or deletion) of each update operation is arbitrary, i.e., not random. We use our technique to analyze existing and new dynamic algorithms for the following problems: maximum cardinality matching, minimum spanning forest, connectivity, 2-edge connectivity, k -edge connectivity, k -vertex connectivity, and bipartiteness. Given a random graph G with m 0 edges and n vertices and a sequence of l update operations such that the graph contains m i edges after operation i , the expected time for performing the updates for any l is O(llogn+∑li=1n/m−−√i) in the case of minimum spanning forests, connectivity, 2-edge connectivity, and bipartiteness. The expected time per update operation is O(n) in the case of maximum matching. We also give improved bounds for k -edge and k -vertex connectivity. Additionally we give an insertions-only algorithm for maximum cardinality matching with worst-case O(n) amortized time per insertion.","lang":"eng"}],"oa_version":"None","scopus_import":"1","intvolume":" 20","month":"01","date_updated":"2023-02-21T16:33:27Z","extern":"1","_id":"11680","article_type":"original","type":"journal_article","keyword":["Dynamic graph algorithm","Average-case analysis","Minimum spanning forest","Connectivity","Bipartiteness","Maximum matching."],"status":"public"},{"_id":"1450","article_type":"original","type":"journal_article","status":"public","date_updated":"2022-09-01T14:09:49Z","extern":"1","abstract":[{"text":"In this paper we consider the topological side of a problem which is the analogue of Sen's S-duality testing conjecture for Hitchin's moduli space M of rank 2 stable Higgs bundles of fixed determinant of odd degree over a Riemann surface ∑. We prove that all intersection numbers in the compactly supported cohomology of M vanish, i.e. "there are no topological L2 harmonic forms on M". This result generalizes the well known vanishing of the Euler characteristic of the moduli space of rank 2 stable bundles N of fixed determinant of odd degree over ∑. Our proof shows that the vanishing of all intersection numbers of H* cpt(M) is given by relations analogous to the Mumford relations in the cohomology ring of N.","lang":"eng"}],"oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math/9805071"}],"scopus_import":"1","intvolume":" 2","month":"09","publication_status":"published","publication_identifier":{"issn":["1095-0761"]},"language":[{"iso":"eng"}],"volume":2,"issue":"5","citation":{"mla":"Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of Higgs Bundles.” Advances in Theoretical and Mathematical Physics, vol. 2, no. 5, International Press, 1998, pp. 1011–40, doi:10.4310/ATMP.1998.v2.n5.a3.","ama":"Hausel T. Vanishing of intersection numbers on the moduli space of Higgs bundles. Advances in Theoretical and Mathematical Physics. 1998;2(5):1011-1040. doi:10.4310/ATMP.1998.v2.n5.a3","apa":"Hausel, T. (1998). Vanishing of intersection numbers on the moduli space of Higgs bundles. Advances in Theoretical and Mathematical Physics. International Press. https://doi.org/10.4310/ATMP.1998.v2.n5.a3","short":"T. Hausel, Advances in Theoretical and Mathematical Physics 2 (1998) 1011–1040.","ieee":"T. Hausel, “Vanishing of intersection numbers on the moduli space of Higgs bundles,” Advances in Theoretical and Mathematical Physics, vol. 2, no. 5. International Press, pp. 1011–1040, 1998.","chicago":"Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of Higgs Bundles.” Advances in Theoretical and Mathematical Physics. International Press, 1998. https://doi.org/10.4310/ATMP.1998.v2.n5.a3.","ista":"Hausel T. 1998. Vanishing of intersection numbers on the moduli space of Higgs bundles. Advances in Theoretical and Mathematical Physics. 2(5), 1011–1040."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"arxiv":["math/9805071"]},"article_processing_charge":"No","author":[{"first_name":"Tamas","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","last_name":"Hausel","full_name":"Hausel, Tamas"}],"publist_id":"5747","title":"Vanishing of intersection numbers on the moduli space of Higgs bundles","acknowledgement":"First of all I would like to thank my supervisor Nigel Hitchin for suggesting Problem 1, and for his help and \r\n encouragement. I am grateful to Michael Thaddeus for his inspiring paper [Thai], enlightening communications and his constant interest in my work. I am also indebted to Manfred Lehn for the idea of the proof of Theorem 6.2. I have found\r\nconversations with Michael Atiyah, Frances Kirwan and Graeme Segal very stimulating. I thank the Mathematical Institute and St. Catherine's College, Oxford for their hospitality during the preparation of this work. Finally I thank Trinity College, Cambridge for financial support.","oa":1,"quality_controlled":"1","publisher":"International Press","year":"1998","publication":"Advances in Theoretical and Mathematical Physics","day":"01","page":"1011 - 1040","date_created":"2018-12-11T11:52:06Z","doi":"10.4310/ATMP.1998.v2.n5.a3","date_published":"1998-09-01T00:00:00Z"},{"intvolume":" 1998","month":"10","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math/9804083"}],"scopus_import":"1","oa_version":"Preprint","abstract":[{"text":"In this paper we consider a canonical compactification of M, the moduli space of stable Higgs bundles with fixed determinant of odd degree over a Riemann surface Σ, producing a projective variety M̄ = M ∪ Z. We give a detailed study of the spaces M̄, Z and M. In doing so we reprove some assertions of Laumon and Thaddeus on the nilpotent cone.","lang":"eng"}],"issue":"503","volume":1998,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["1435-5345"]},"status":"public","article_type":"original","type":"journal_article","_id":"1449","extern":"1","date_updated":"2022-09-01T13:51:07Z","oa":1,"publisher":"Walter de Gruyter","quality_controlled":"1","date_created":"2018-12-11T11:52:05Z","doi":"10.1515/crll.1998.096","date_published":"1998-10-01T00:00:00Z","page":"169 - 192","publication":"Journal fur die Reine und Angewandte Mathematik","day":"01","year":"1998","title":"Compactification of moduli of Higgs bundles","article_processing_charge":"No","external_id":{"arxiv":["math/9804083"]},"publist_id":"5746","author":[{"last_name":"Hausel","full_name":"Hausel, Tamas","first_name":"Tamas","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Hausel T. 1998. Compactification of moduli of Higgs bundles. Journal fur die Reine und Angewandte Mathematik. 1998(503), 169–192.","chicago":"Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” Journal Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter, 1998. https://doi.org/10.1515/crll.1998.096.","short":"T. Hausel, Journal Fur Die Reine Und Angewandte Mathematik 1998 (1998) 169–192.","ieee":"T. Hausel, “Compactification of moduli of Higgs bundles,” Journal fur die Reine und Angewandte Mathematik, vol. 1998, no. 503. Walter de Gruyter, pp. 169–192, 1998.","ama":"Hausel T. Compactification of moduli of Higgs bundles. Journal fur die Reine und Angewandte Mathematik. 1998;1998(503):169-192. doi:10.1515/crll.1998.096","apa":"Hausel, T. (1998). Compactification of moduli of Higgs bundles. Journal Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter. https://doi.org/10.1515/crll.1998.096","mla":"Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” Journal Fur Die Reine Und Angewandte Mathematik, vol. 1998, no. 503, Walter de Gruyter, 1998, pp. 169–92, doi:10.1515/crll.1998.096."}},{"article_processing_charge":"No","external_id":{"pmid":["9448329 "]},"publist_id":"5130","author":[{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Burrows","full_name":"Burrows, Paul","first_name":"Paul"},{"first_name":"Peter","last_name":"Nixon","full_name":"Nixon, Peter"}],"title":"The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes","citation":{"chicago":"Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “The Plastid Ndh Genes Code for an NADH-Specific Dehydrogenase: Isolation of a Complex I Analogue from Pea Thylakoid Membranes.” PNAS. National Academy of Sciences, 1998. https://doi.org/10.1073/pnas.95.3.1319.","ista":"Sazanov LA, Burrows P, Nixon P. 1998. The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes. PNAS. 95(3), 1319–1324.","mla":"Sazanov, Leonid A., et al. “The Plastid Ndh Genes Code for an NADH-Specific Dehydrogenase: Isolation of a Complex I Analogue from Pea Thylakoid Membranes.” PNAS, vol. 95, no. 3, National Academy of Sciences, 1998, pp. 1319–24, doi:10.1073/pnas.95.3.1319.","apa":"Sazanov, L. A., Burrows, P., & Nixon, P. (1998). The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.95.3.1319","ama":"Sazanov LA, Burrows P, Nixon P. The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes. PNAS. 1998;95(3):1319-1324. doi:10.1073/pnas.95.3.1319","short":"L.A. Sazanov, P. Burrows, P. Nixon, PNAS 95 (1998) 1319–1324.","ieee":"L. A. Sazanov, P. Burrows, and P. Nixon, “The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes,” PNAS, vol. 95, no. 3. National Academy of Sciences, pp. 1319–1324, 1998."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa":1,"publisher":"National Academy of Sciences","quality_controlled":"1","acknowledgement":"We gratefully acknowledge Dr. A.Carne (Institute of Cancer Research, London, U.K.) for help with N-terminal sequencing. We thank Prof. C. J. Leaver (University of Oxford, U.K.), Prof. K.-H. Süss (Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany), and Prof. L. J. Rogers (University of Aberystwyth, U.K.) for gifts of antiserum against maize mitochondrial cytochrome oxidase subunit 1 and cytochrome bc1 complex, spinach FNR, and spinach ferredoxin, respectively. This work was supported by grants from The Royal Society and the Biotechnology and Biological Sciences Research Council.","page":"1319 - 1324","date_created":"2018-12-11T11:54:54Z","doi":"10.1073/pnas.95.3.1319","date_published":"1998-02-03T00:00:00Z","year":"1998","publication":"PNAS","day":"03","article_type":"original","type":"journal_article","status":"public","_id":"1956","date_updated":"2022-09-01T13:47:05Z","extern":"1","main_file_link":[{"open_access":"1","url":"https://europepmc.org/article/pmc/18756"}],"scopus_import":"1","intvolume":" 95","month":"02","abstract":[{"text":"\r\nThe plastid genomes of several plants contain ndh genes-homologues of genes encoding subunits of the proton-pumping NADH:ubiquinone oxidoreductase, or complex I, involved in respiration in mitochondria and eubacteria. From sequence similarities with these genes, the ndh gene products have been suggested to form a large protein complex (Ndh complex); however, the structure and function of this complex remains to be established. Herein we report the isolation of the Ndh complex from the chloroplasts of the higher plant Pisum sativum. The purification procedure involved selective solubilization of the thylakoid membrane with dodecyl maltoside, followed by two anion-exchange chromatography steps and one size-exclusion chromatography step. The isolated Ndh complex has an apparent total molecular mass of approximately 550 kDa and according to SDS/PAGE consists of at least 16 subunits including NdhA, NdhI, NdhJ, NdhK, and NdhH, which were identified by N-terminal sequencing and immunoblotting. The Ndh complex showed an NADH- and deamino-NADH-specific dehydrogenase activity, characteristic of complex I, when either ferricyanide or the quinones menadione and duroquinone were used as electron acceptors. This study describes the isolation of the chloroplast analogue of the respiratory complex I and provides direct evidence for the function of the plastid Ndh complex as an NADH:plastoquinone oxidoreductase. Our results are compatible with a dual role for the Ndh complex in the chloro-respiratory and cyclic photophosphorylation pathways.","lang":"eng"}],"pmid":1,"oa_version":"None","volume":95,"issue":"3","publication_status":"published","publication_identifier":{"issn":["0027-8424"]},"language":[{"iso":"eng"}]},{"status":"public","type":"journal_article","article_type":"original","_id":"1955","extern":"1","date_updated":"2022-09-01T13:17:49Z","month":"02","intvolume":" 17","scopus_import":"1","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170436/"}],"pmid":1,"oa_version":"None","abstract":[{"text":"The plastid genomes of several plants contain homologues, termed ndh genes, of genes encoding subunits of the NADH:ubiquinone oxidoreductase or complex I of mitochondria and eubacteria. The functional significance of the Ndh proteins in higher plants is uncertain. We show here that tobacco chloroplasts contain a protein complex of 550 kDa consisting of at least three of the ndh gene products: NdhI, NdhJ and NdhK. We have constructed mutant tobacco plants with disrupted ndhC, ndhK and ndhJ plastid genes, indicating that the Ndh complex is dispensible for plant growth under optimal growth conditions. Chlorophyll fluorescence analysis shows that in vivo the Ndh complex catalyses the post-illumination reduction of the plastoquinone pool and in the light optimizes the induction of photosynthesis under conditions of water stress. We conclude that the Ndh complex catalyses the reduction of the plastoquinone pool using stromal reductant and so acts as a respiratory complex. Overall, our data are compatible with the participation of the Ndh complex in cyclic electron flow around the photosystem I complex in the light and possibly in a chloroplast respiratory chain in the dark.","lang":"eng"}],"volume":17,"issue":"4","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0261-4189"]},"publication_status":"published","title":"Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes","publist_id":"5129","author":[{"full_name":"Burrows, Paul","last_name":"Burrows","first_name":"Paul"},{"last_name":"Sazanov","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Zóra","last_name":"Sváb","full_name":"Sváb, Zóra"},{"first_name":"Pàl","full_name":"Maliga, Pàl","last_name":"Maliga"},{"last_name":"Nixon","full_name":"Nixon, Peter","first_name":"Peter"}],"external_id":{"pmid":["9463365"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Burrows, Paul, et al. “Identification of a Functional Respiratory Complex in Chloroplasts through Analysis of Tobacco Mutants Containing Disrupted Plastid Ndh Genes.” EMBO Journal, vol. 17, no. 4, Wiley-Blackwell, 1998, pp. 868–76, doi:10.1093/emboj/17.4.868.","short":"P. Burrows, L.A. Sazanov, Z. Sváb, P. Maliga, P. Nixon, EMBO Journal 17 (1998) 868–876.","ieee":"P. Burrows, L. A. Sazanov, Z. Sváb, P. Maliga, and P. Nixon, “Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes,” EMBO Journal, vol. 17, no. 4. Wiley-Blackwell, pp. 868–876, 1998.","apa":"Burrows, P., Sazanov, L. A., Sváb, Z., Maliga, P., & Nixon, P. (1998). Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1093/emboj/17.4.868","ama":"Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal. 1998;17(4):868-876. doi:10.1093/emboj/17.4.868","chicago":"Burrows, Paul, Leonid A Sazanov, Zóra Sváb, Pàl Maliga, and Peter Nixon. “Identification of a Functional Respiratory Complex in Chloroplasts through Analysis of Tobacco Mutants Containing Disrupted Plastid Ndh Genes.” EMBO Journal. Wiley-Blackwell, 1998. https://doi.org/10.1093/emboj/17.4.868.","ista":"Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. 1998. Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal. 17(4), 868–876."},"quality_controlled":"1","publisher":"Wiley-Blackwell","oa":1,"acknowledgement":"We thank Professor Süss (Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany) for the gift of the anti-FNR antiserum, Professor Masahiro Sugiura (Nagoya University, Japan) for the gift of plasmid pTB19 and Professor Peter Horton (University of Sheffield) for the loan of his ED-800T unit. P.B. is a recipient of a BBSRC studentship and the work was supported by grants from the BBSRC, The Royal Society (to P.J.N.) and The National Science Foundation (to P.M.).","date_published":"1998-02-04T00:00:00Z","doi":"10.1093/emboj/17.4.868","date_created":"2018-12-11T11:54:54Z","page":"868 - 876","day":"04","publication":"EMBO Journal","year":"1998"},{"title":"The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves","article_processing_charge":"No","external_id":{"pmid":["9657394 "]},"publist_id":"5128","author":[{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A"},{"first_name":"Paul","last_name":"Burrows","full_name":"Burrows, Paul"},{"first_name":"Peter","full_name":"Nixon, Peter","last_name":"Nixon"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Sazanov LA, Burrows P, Nixon P. 1998. The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Letters. 429(1), 115–118.","chicago":"Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “The Chloroplast Ndh Complex Mediates the Dark Reduction of the Plastoquinone Pool in Response to Heat Stress in Tobacco Leaves.” FEBS Letters. Elsevier, 1998. https://doi.org/10.1016/S0014-5793(98)00573-0.","ieee":"L. A. Sazanov, P. Burrows, and P. Nixon, “The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves,” FEBS Letters, vol. 429, no. 1. Elsevier, pp. 115–118, 1998.","short":"L.A. Sazanov, P. Burrows, P. Nixon, FEBS Letters 429 (1998) 115–118.","apa":"Sazanov, L. A., Burrows, P., & Nixon, P. (1998). The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Letters. Elsevier. https://doi.org/10.1016/S0014-5793(98)00573-0","ama":"Sazanov LA, Burrows P, Nixon P. The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Letters. 1998;429(1):115-118. doi:10.1016/S0014-5793(98)00573-0","mla":"Sazanov, Leonid A., et al. “The Chloroplast Ndh Complex Mediates the Dark Reduction of the Plastoquinone Pool in Response to Heat Stress in Tobacco Leaves.” FEBS Letters, vol. 429, no. 1, Elsevier, 1998, pp. 115–18, doi:10.1016/S0014-5793(98)00573-0."},"date_created":"2018-12-11T11:54:54Z","doi":"10.1016/S0014-5793(98)00573-0","date_published":"1998-06-05T00:00:00Z","page":"115 - 118","publication":"FEBS Letters","day":"05","year":"1998","quality_controlled":"1","publisher":"Elsevier","acknowledgement":"This work was funded by the BBSRC. We would like to thank Professor Peter Horton (University of Sheffield) for the loan of the ED 800 T unit.","extern":"1","date_updated":"2022-09-01T13:12:15Z","status":"public","type":"journal_article","article_type":"original","_id":"1954","volume":429,"issue":"1","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0014-5793"]},"intvolume":" 429","month":"06","oa_version":"None","pmid":1,"abstract":[{"lang":"eng","text":"\r\nWe have examined the effects of heat stress on electron transfer in the thylakoid membrane of an engineered plastid ndh deletion mutant, Δ1, incapable of performing the Ndh-mediated reduction of the plastoquinone pool in the chloroplast. Upon heat stress in the dark, the rate of PSII- independent reduction of PSI after subsequent illumination by far-red light is dramatically enhanced in both Δ1 and a wild-type control plant (WT). In contrast, in the dark, only the WT shows an increase in the reduction state of the plastoquinone pool. We conclude that the heat stress-induced reduction of the intersystem electron transport chain can be mediated by Ndh- independent pathways in the light but that in the dark the dominant pathway for reduction of the plastoquinone pool is catalysed by the Ndh complex. Our results therefore demonstrate a functional role for the Ndh complex in the dark.\r\n"}]},{"issue":"3","volume":393,"publication_identifier":{"issn":["0021-9967"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","month":"03","intvolume":" 393","abstract":[{"lang":"eng","text":"The distributions of two alternative splicing variants of metabotropic glutamate receptor mGluR7, mGluR7a and mGluR7b, were examined immunohistochemically in the rat and mouse by using variant-specific antibodies raised against C-terminal portions of rat mGluR7a and human mGluR7b. Many regions throughout the central nervous system (CNS) showed mGluR7-like immunoreactivities (LI). The distribution patterns of mGluR7-LI in the rat were substantially the same as those in the mouse, although some species differences were observed in a few regions. Intense mGluR7a-LI was seen in the main and accessory olfactory bulbs, anterior olfactory nucleus, islands of Calleja, superficial layers of the olfactory tubercle, piriform cortex and entorhinal cortex, periamygdaloid cortex, amygdalohippocampal area, hippocampus, layer I of the neocortical regions, globus pallidus, superficial layers of the superior colliculus, locus coeruleus, and superficial layers of the medullary and spinal dorsal horns. The distribution of mGluR7b was more restricted. It was intense in the islands of Calleja, substantia innominata, hippocampus, ventral pallidum, and globus pallidus. The medial habenular nucleus also showed intense mGluR7a-LI in the rat but not in the mouse. For both mGluR7a- and mGluR7b-LI, localization in the active zones of presynaptic axon terminals was confirmed electron microscopically at synapses of both the asymmetrical and symmetrical types. It is noteworthy that mGluR7a-LI is seen preferentially in relay nuclei of the sensory pathways and that both mGluR7a- and mGluR7b-LI are observed not only in presumed glutamatergic axon terminals, but also in non-glutamatergic axon terminals including presumed inhibitory ones. Thus, mGluR7 may play roles not only as an autoreceptor in glutamatergic axon terminals, but also as a presynaptic heteroreceptor in non-glutamatergic axon terminals in various CNS regions."}],"oa_version":"None","pmid":1,"date_updated":"2022-09-01T12:11:04Z","extern":"1","type":"journal_article","article_type":"original","status":"public","_id":"2584","page":"332 - 352","date_published":"1998-03-13T00:00:00Z","doi":"10.1002/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","date_created":"2018-12-11T11:58:31Z","year":"1998","day":"13","publication":"Journal of Comparative Neurology","quality_controlled":"1","publisher":"Wiley-Blackwell","acknowledgement":"The authors are grateful for photographic help of Mr.Akira Uesugi, and the support of Dr. Kajitaro Morita inMorita Clinic of Internal Medicine and Pediatrics, Kadoma,Osaka, Japan. The authors also express gratitude for thesupport of Dr. Satoru Fukuchi, Dr. Ritsu Hayashi, Dr.Sohzaburo Hayashi, Dr. Mizuho Katsurada, Dr. HitoshiKawai, Dr. Yutaka Kitani, Dr. Toshihiko Kuroda, Dr. KeikoKumagai, Dr. Hiroshi Matsubara, Dr. Hiroshi Mat-sushima, Dr. Chisato Minakuchi, Dr. Gonpei Niwa, Dr.Hajime Oda, Dr. Mashiko Ohbayashi, Dr. Sei-ichi Ohbaya-shi, Dr. Hiroyasu Ohtsuka, Dr. Shigeo Tamaki, Dr. EizoWatanabe, Dr. Kazuo Yoshino, and Dr. Toshiaki Yoshino.","author":[{"first_name":"Ayae","full_name":"Kinoshita, Ayae","last_name":"Kinoshita"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Ohishi, Hitoshi","last_name":"Ohishi","first_name":"Hitoshi"},{"first_name":"Herman","last_name":"Van Der Putten","full_name":"Van Der Putten, Herman"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"publist_id":"4314","external_id":{"pmid":["9548554"]},"article_processing_charge":"No","title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study","citation":{"mla":"Kinoshita, Ayae, et al. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR7a and MGluR7b, in the Central Nervous System of the Adult Rat and Mouse: A Light and Electron Microscopic Study.” Journal of Comparative Neurology, vol. 393, no. 3, Wiley-Blackwell, 1998, pp. 332–52, doi:10.1002/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2.","ama":"Kinoshita A, Shigemoto R, Ohishi H, Van Der Putten H, Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study. Journal of Comparative Neurology. 1998;393(3):332-352. doi:10.1002/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","apa":"Kinoshita, A., Shigemoto, R., Ohishi, H., Van Der Putten, H., & Mizuno, N. (1998). Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","ieee":"A. Kinoshita, R. Shigemoto, H. Ohishi, H. Van Der Putten, and N. Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study,” Journal of Comparative Neurology, vol. 393, no. 3. Wiley-Blackwell, pp. 332–352, 1998.","short":"A. Kinoshita, R. Shigemoto, H. Ohishi, H. Van Der Putten, N. Mizuno, Journal of Comparative Neurology 393 (1998) 332–352.","chicago":"Kinoshita, Ayae, Ryuichi Shigemoto, Hitoshi Ohishi, Herman Van Der Putten, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR7a and MGluR7b, in the Central Nervous System of the Adult Rat and Mouse: A Light and Electron Microscopic Study.” Journal of Comparative Neurology. Wiley-Blackwell, 1998. https://doi.org/10.1002/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2.","ista":"Kinoshita A, Shigemoto R, Ohishi H, Van Der Putten H, Mizuno N. 1998. Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study. Journal of Comparative Neurology. 393(3), 332–352."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"external_id":{"pmid":["9550154"]},"article_processing_charge":"No","publist_id":"4313","author":[{"full_name":"Wada, Eiki","last_name":"Wada","first_name":"Eiki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"last_name":"Kinoshita","full_name":"Kinoshita, Ayae","first_name":"Ayae"},{"full_name":"Ohishi, Hitoshi","last_name":"Ohishi","first_name":"Hitoshi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}],"title":"Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: A light and electron microscopic immunohistochemical study in the rat","citation":{"chicago":"Wada, Eiki, Ryuichi Shigemoto, Ayae Kinoshita, Hitoshi Ohishi, and Noboru Mizuno. “Metabotropic Glutamate Receptor Subtypes in Axon Terminals of Projection Fibers from the Main and Accessory Olfactory Bulbs: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology. Wiley-Blackwell, 1998. https://doi.org/10.1002/(SICI)1096-9861(19980420)393:4<493::AID-CNE8>3.0.CO;2-W.","ista":"Wada E, Shigemoto R, Kinoshita A, Ohishi H, Mizuno N. 1998. Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: A light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 393(4), 493–504.","mla":"Wada, Eiki, et al. “Metabotropic Glutamate Receptor Subtypes in Axon Terminals of Projection Fibers from the Main and Accessory Olfactory Bulbs: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Journal of Comparative Neurology, vol. 393, no. 4, Wiley-Blackwell, 1998, pp. 493–504, doi:10.1002/(SICI)1096-9861(19980420)393:4<493::AID-CNE8>3.0.CO;2-W.","short":"E. Wada, R. Shigemoto, A. Kinoshita, H. Ohishi, N. Mizuno, Journal of Comparative Neurology 393 (1998) 493–504.","ieee":"E. Wada, R. Shigemoto, A. Kinoshita, H. Ohishi, and N. Mizuno, “Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: A light and electron microscopic immunohistochemical study in the rat,” Journal of Comparative Neurology, vol. 393, no. 4. Wiley-Blackwell, pp. 493–504, 1998.","apa":"Wada, E., Shigemoto, R., Kinoshita, A., Ohishi, H., & Mizuno, N. (1998). Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: A light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19980420)393:4<493::AID-CNE8>3.0.CO;2-W","ama":"Wada E, Shigemoto R, Kinoshita A, Ohishi H, Mizuno N. Metabotropic glutamate receptor subtypes in axon terminals of projection fibers from the main and accessory olfactory bulbs: A light and electron microscopic immunohistochemical study in the rat. Journal of Comparative Neurology. 1998;393(4):493-504. doi:10.1002/(SICI)1096-9861(19980420)393:4<493::AID-CNE8>3.0.CO;2-W"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"493 - 504","date_created":"2018-12-11T11:58:31Z","date_published":"1998-04-20T00:00:00Z","doi":"10.1002/(SICI)1096-9861(19980420)393:4<493::AID-CNE8>3.0.CO;2-W","year":"1998","publication":"Journal of Comparative Neurology","day":"20","publisher":"Wiley-Blackwell","quality_controlled":"1","acknowledgement":"The authors are grateful for photographic help of Mr.Akira Uesugi. The authors also express their gratitudesfor the support of Dr. Satoru Fukuchi, Dr. Ritsu Hayashi,Dr. Sohzaburo Hayashi, Dr. Mizuho Katsurada, Dr. Hitoshi Kawai, Dr. Yutaka Kitani, Dr. Toshihiko Kuroda, Dr.Keiko Kumagai, Dr. Hiroshi Matsubara, Dr. Hiroshi Matsushima, Dr. Chisato Minakuchi, Dr. Gonpei Niwa, Dr.Hajime Oda, Dr. Mashiko Ohbayashi, Dr. Seiichi Ohbayashi, Dr. Hiroyasu Ohtsuka, Dr. Shigeo Tamaki, Dr. EizoWatanabe, Dr. Kazuo Yoshino, and Dr. Toshiaki Yoshino.","date_updated":"2022-08-31T14:53:58Z","extern":"1","type":"journal_article","article_type":"original","status":"public","_id":"2585","issue":"4","volume":393,"publication_status":"published","publication_identifier":{"issn":["0021-9967"]},"language":[{"iso":"eng"}],"scopus_import":"1","intvolume":" 393","month":"04","abstract":[{"text":"Localization of metabetropic glutamate receptor subtypes, mGluR1, mGluRlu, mGluR2/3, mGluR4a, mGluR5, mGluR7a, mGluR7b, and mGluR8, was examined in some of the target areas of projection fibers from the main and accessory olfactory bulbs (MOB and AOB) by using subtype-specific antibodies. The superficial layer of the olfactory tubercle and layer Ia of the pitiform cortex, the target areas of MOB, showed marked mGluR1-, mGluR5-, mGluR7a-, and mGluR8-like immunoreactivities (-LI), and rather weak mGluR2/3-LI. The periamygdaloid cortical region including the target areas of both MOB and AOB showed intense mGluR2/3-LI as well as marked mGluRl-, mGluR5-, mGluR7a-, and mGluRS-LI. No significant mGluR1a-, mGluR4a-, or mGluR7b-LI was seen in these regions. After transection of the lateral olfactory tract, mGluR2/3-, mGluR7a-, and mGluR8-LI were reduced markedly in the target regions on the side ipsilateral to the transection; no significant changes were detected in mGluR1- or mGIuR5-LI. Double labeling experiments indicated light and electron microscopically colocalization of mGluR7a- and mGluRS-LI in axon terminals on dendritic shafts of presumed interneurons in the superficial layer of the olfactory tubercle and layer Ia of the piriform cortex. Electron microscopically mGluR2/3-LI was seen in preterminal and terminal portions of axons, whereas mGluR7a- and mGluRS-LI were associated with presynaptic membrane specialization. Immunolabeled axon terminals were filled with round synaptic vesicles and constituted asymmetric synapses with dendritic profiles. The results suggest that glutamate release from axon terminals of projection fibers from MOB and AOB is regulated presynaptically and differentially through mGluR2/3, mGluR7a, and/or mGluRS.","lang":"eng"}],"pmid":1,"oa_version":"None"},{"external_id":{"pmid":["9778244 "]},"article_processing_charge":"No","author":[{"full_name":"Watanabe, Dai","last_name":"Watanabe","first_name":"Dai"},{"last_name":"Inokawa","full_name":"Inokawa, Hitoshi","first_name":"Hitoshi"},{"full_name":"Hashimoto, Kouichi","last_name":"Hashimoto","first_name":"Kouichi"},{"first_name":"Noboru","full_name":"Suzuki, Noboru","last_name":"Suzuki"},{"full_name":"Kano, Masanobu","last_name":"Kano","first_name":"Masanobu"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"full_name":"Hirano, Tomoo","last_name":"Hirano","first_name":"Tomoo"},{"last_name":"Toyama","full_name":"Toyama, Keisuke","first_name":"Keisuke"},{"full_name":"Kaneko, Satoshi","last_name":"Kaneko","first_name":"Satoshi"},{"first_name":"Mineto","full_name":"Yokoi, Mineto","last_name":"Yokoi"},{"first_name":"Koki","full_name":"Moriyoshi, Koki","last_name":"Moriyoshi"},{"last_name":"Suzuki","full_name":"Suzuki, Misao","first_name":"Misao"},{"full_name":"Kobayashi, Kazuto","last_name":"Kobayashi","first_name":"Kazuto"},{"first_name":"Toshiharu","last_name":"Nagatsu","full_name":"Nagatsu, Toshiharu"},{"last_name":"Kreitman","full_name":"Kreitman, Robert","first_name":"Robert"},{"first_name":"Ira","full_name":"Pastan, Ira","last_name":"Pastan"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"publist_id":"4312","title":"Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination","citation":{"chicago":"Watanabe, Dai, Hitoshi Inokawa, Kouichi Hashimoto, Noboru Suzuki, Masanobu Kano, Ryuichi Shigemoto, Tomoo Hirano, et al. “Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination.” Cell. Cell Press, 1998. https://doi.org/10.1016/S0092-8674(00)81779-1.","ista":"Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, Hirano T, Toyama K, Kaneko S, Yokoi M, Moriyoshi K, Suzuki M, Kobayashi K, Nagatsu T, Kreitman R, Pastan I, Nakanishi S. 1998. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. 95(1), 17–27.","mla":"Watanabe, Dai, et al. “Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination.” Cell, vol. 95, no. 1, Cell Press, 1998, pp. 17–27, doi:10.1016/S0092-8674(00)81779-1.","short":"D. Watanabe, H. Inokawa, K. Hashimoto, N. Suzuki, M. Kano, R. Shigemoto, T. Hirano, K. Toyama, S. Kaneko, M. Yokoi, K. Moriyoshi, M. Suzuki, K. Kobayashi, T. Nagatsu, R. Kreitman, I. Pastan, S. Nakanishi, Cell 95 (1998) 17–27.","ieee":"D. Watanabe et al., “Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination,” Cell, vol. 95, no. 1. Cell Press, pp. 17–27, 1998.","ama":"Watanabe D, Inokawa H, Hashimoto K, et al. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. 1998;95(1):17-27. doi:10.1016/S0092-8674(00)81779-1","apa":"Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., … Nakanishi, S. (1998). Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(00)81779-1"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publisher":"Cell Press","quality_controlled":"1","acknowledgement":"We thank Kumlesh K Dev for careful reading of this manuscript, Peter Somogyi and Hirohide Sawada for invaluable advice, and Akira Uesugi for photographic assistance. This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan. the Sankyo Foundation. the Yamanouchi Founda-tion. the Biomolecular Engineering Research Institute, CREST and the International Resource Program of the National Cancer Institute. \r\n","page":"17 - 27","date_created":"2018-12-11T11:58:32Z","doi":"10.1016/S0092-8674(00)81779-1","date_published":"1998-10-02T00:00:00Z","year":"1998","publication":"Cell","day":"02","type":"journal_article","article_type":"original","status":"public","_id":"2586","date_updated":"2022-08-31T13:46:20Z","extern":"1","scopus_import":"1","intvolume":" 95","month":"10","abstract":[{"text":"The role of inhibitory Golgi cells in cerebellar function was investigated by selectively ablating Golgi cells expressing human interleukin-2 receptor α subunit in transgenic mice, using the immunotoxin- mediated cell targeting technique. Golgi cell disruption caused severe acute motor disorders. These mice showed gradual recovery but retained a continuing inability to perform compound movements. Optical and electrical recordings combined with immunocytological analysis indicated that elimination of Golgi cells not only reduces GABA-mediated inhibition but also attenuates functional NMDA receptors in granule cells. These results demonstrate that synaptic integration involving both GABA inhibition and NMDA receptor activation is essential for compound motor coordination. Furthermore, this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors.","lang":"eng"}],"oa_version":"None","pmid":1,"volume":95,"issue":"1","publication_status":"published","publication_identifier":{"issn":["0092-8674"]},"language":[{"iso":"eng"}]},{"extern":"1","date_updated":"2022-09-01T12:19:44Z","_id":"2583","status":"public","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0168-0102"]},"publication_status":"published","volume":30,"issue":"3","oa_version":"None","pmid":1,"abstract":[{"text":"Substance P receptor (SPR)-immunoreactive neurons projecting to the periaqueductal gray (PAG) were examined in the rat spinal trigeminal nucleus and spinal cord by a retrograde tracing method combined with immunofluorescence histochemistry. After injection of Fluoro-gold (FG) into the PAG, SPR-immunoreactive neurons labeled with FG were observed mainly in the lateral spinal nucleus and lamina I of the medullary and spinal dorsal horns and additionally in laminae V and X of the spinal cord.","lang":"eng"}],"month":"03","intvolume":" 30","scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Li J, Ding Y, Xiong K, Li J, Shigemoto R, Mizuno N. 1998. Substance P receptor (NK1)-immunoreactive neurons projecting to the periaqueductal gray: Distribution in the spinal trigeminal nucleus and the spinal cord of the rat. Neuroscience Research. 30(3), 219–225.","chicago":"Li, Jin, Yu Ding, Kang Xiong, Ji Li, Ryuichi Shigemoto, and Noboru Mizuno. “Substance P Receptor (NK1)-Immunoreactive Neurons Projecting to the Periaqueductal Gray: Distribution in the Spinal Trigeminal Nucleus and the Spinal Cord of the Rat.” Neuroscience Research. Elsevier, 1998. https://doi.org/10.1016/S0168-0102(97)00132-6.","ama":"Li J, Ding Y, Xiong K, Li J, Shigemoto R, Mizuno N. Substance P receptor (NK1)-immunoreactive neurons projecting to the periaqueductal gray: Distribution in the spinal trigeminal nucleus and the spinal cord of the rat. Neuroscience Research. 1998;30(3):219-225. doi:10.1016/S0168-0102(97)00132-6","apa":"Li, J., Ding, Y., Xiong, K., Li, J., Shigemoto, R., & Mizuno, N. (1998). Substance P receptor (NK1)-immunoreactive neurons projecting to the periaqueductal gray: Distribution in the spinal trigeminal nucleus and the spinal cord of the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(97)00132-6","ieee":"J. Li, Y. Ding, K. Xiong, J. Li, R. Shigemoto, and N. Mizuno, “Substance P receptor (NK1)-immunoreactive neurons projecting to the periaqueductal gray: Distribution in the spinal trigeminal nucleus and the spinal cord of the rat,” Neuroscience Research, vol. 30, no. 3. Elsevier, pp. 219–225, 1998.","short":"J. Li, Y. Ding, K. Xiong, J. Li, R. Shigemoto, N. Mizuno, Neuroscience Research 30 (1998) 219–225.","mla":"Li, Jin, et al. “Substance P Receptor (NK1)-Immunoreactive Neurons Projecting to the Periaqueductal Gray: Distribution in the Spinal Trigeminal Nucleus and the Spinal Cord of the Rat.” Neuroscience Research, vol. 30, no. 3, Elsevier, 1998, pp. 219–25, doi:10.1016/S0168-0102(97)00132-6."},"title":"Substance P receptor (NK1)-immunoreactive neurons projecting to the periaqueductal gray: Distribution in the spinal trigeminal nucleus and the spinal cord of the rat","publist_id":"4315","author":[{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"first_name":"Yu","full_name":"Ding, Yu","last_name":"Ding"},{"last_name":"Xiong","full_name":"Xiong, Kang","first_name":"Kang"},{"first_name":"Ji","last_name":"Li","full_name":"Li, Ji"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"article_processing_charge":"No","external_id":{"pmid":["9593332"]},"day":"01","publication":"Neuroscience Research","year":"1998","doi":"10.1016/S0168-0102(97)00132-6","date_published":"1998-03-01T00:00:00Z","date_created":"2018-12-11T11:58:31Z","page":"219 - 225","acknowledgement":"The authors are grateful for the support of Dr Kajitaro Morita of the Morita Clinic of Internal Medicine and Pediatrics at Kadoma, Osaka and for the help of Yue-Ping Yuan and Akira Uesugi with photography. This work was supported in part by Grants-in-Aid from the National Natural Science Foundation of China (39600045) and the Ministry of Education, Sci-\r\nence, Sports and Culture of Japan (09480211, 08458245).","publisher":"Elsevier","quality_controlled":"1"},{"oa_version":"None","pmid":1,"abstract":[{"text":"Unipolar brush cells (UBCs) are a class of small neurons that are densely concentrated in the granular layers of the vestibulocerebellar cortex and dorsal cochlear nucleus. The UBCs form giant synapses with individual mossy fibre rosettes on the dendrioles which make up their brush formations and are provided with numerous, unusual non-synaptic appendages. In accord with the glutamatergic nature of mossy fibres, our previous post-embedding immunocytochemical studies indicated that various ionotropic glutamate receptor subunits are localized at the post-synaptic densities of the giant synapses, whereas the non-synaptic appendages are immunonegative. On the contrary, the metabotropic glutamate receptors mGluR1α and mGluR2/3 are situated at the non-synaptic appendages and are lacking at the post-synaptic densities. Other authors, however, have shown that antibodies to these metabotropic receptors stain both appendages and post-synaptic densities. In the present study, we have re-evaluated the distribution of metabotropic glutamate receptors in the UBCs of the cerebellum and the cochlear nuclear complex by light and electron microscopic pre-embedding immunocytochemistry with subtype-specific antibodies. We confirm that UBCs dendritic brushes are densely immunostained by antibody to mGluR1α particularly in the cerebellum and that antibody to mGluR2/3 labels at least a percentage of the UBC brushes in both the cerebellum and cochlear nuclei. At the ultrastructural level, it appears that mGluR1α and mGluR2/3 immunoreactivities are not associated with the post-synaptic densities of the giant mossy fibre-UBC synapses, but instead are concentrated on the non-synaptic appendages of the cerebellar UBCs. The non-synaptic appendages, therefore, may be an important avenue for regulating the excitability of UBCs and mediating glutamate effects on their still unknown intracellular signal transduction cascades. We also show that the pre-synaptic densities of UBC dendrodendritic junctions are mGluR2/3 positive. As previously demonstrated, antibodies to mGluR1α and mGluR2/3 label subsets of Golgi cells. Antibody to mGluR5 does not stain UBCs in the cerebellum and cochlear nucleus and reveals the somatodendritic compartment of Golgi cells situated in the core of the cerebellar granular layer, whilst cochlear nucleus Golgi cells are mGluR5 negative.","lang":"eng"}],"intvolume":" 27","month":"01","scopus_import":"1","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0300-4864"]},"volume":27,"issue":"5","_id":"2590","status":"public","type":"journal_article","article_type":"original","extern":"1","date_updated":"2022-08-31T12:30:14Z","acknowledgement":"The authors wish to thank Dr R. L. Huganir and coworkers for kindly providing an aliquot of their mGluR1a antibody and Dr N. Traverse Slater for helpful comments on the manuscript. The study was supported by US-PHS grants NS 09904 and DC 01805 (to E.M.).","publisher":"Kluwer","quality_controlled":"1","publication":"Journal of Neurocytology","day":"01","year":"1998","date_created":"2018-12-11T11:58:33Z","date_published":"1998-01-01T00:00:00Z","doi":"10.1023/A:1006982023657","page":"303 - 327","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Jaarsma D, Diño M, Ohishi H, Shigemoto R, Mugnaini E. 1998. Metabotropic glutamate receptors are associated with non-synaptic appendages of unipolar brush cells in rat cerebellar cortex and cochlear nuclear complex. Journal of Neurocytology. 27(5), 303–327.","chicago":"Jaarsma, Dick, Maria Diño, Hitoshi Ohishi, Ryuichi Shigemoto, and Enrico Mugnaini. “ Metabotropic Glutamate Receptors Are Associated with Non-Synaptic Appendages of Unipolar Brush Cells in Rat Cerebellar Cortex and Cochlear Nuclear Complex.” Journal of Neurocytology. Kluwer, 1998. https://doi.org/10.1023/A:1006982023657.","apa":"Jaarsma, D., Diño, M., Ohishi, H., Shigemoto, R., & Mugnaini, E. (1998). Metabotropic glutamate receptors are associated with non-synaptic appendages of unipolar brush cells in rat cerebellar cortex and cochlear nuclear complex. Journal of Neurocytology. Kluwer. https://doi.org/10.1023/A:1006982023657","ama":"Jaarsma D, Diño M, Ohishi H, Shigemoto R, Mugnaini E. Metabotropic glutamate receptors are associated with non-synaptic appendages of unipolar brush cells in rat cerebellar cortex and cochlear nuclear complex. Journal of Neurocytology. 1998;27(5):303-327. doi:10.1023/A:1006982023657","short":"D. Jaarsma, M. Diño, H. Ohishi, R. Shigemoto, E. Mugnaini, Journal of Neurocytology 27 (1998) 303–327.","ieee":"D. Jaarsma, M. Diño, H. Ohishi, R. Shigemoto, and E. Mugnaini, “ Metabotropic glutamate receptors are associated with non-synaptic appendages of unipolar brush cells in rat cerebellar cortex and cochlear nuclear complex,” Journal of Neurocytology, vol. 27, no. 5. Kluwer, pp. 303–327, 1998.","mla":"Jaarsma, Dick, et al. “ Metabotropic Glutamate Receptors Are Associated with Non-Synaptic Appendages of Unipolar Brush Cells in Rat Cerebellar Cortex and Cochlear Nuclear Complex.” Journal of Neurocytology, vol. 27, no. 5, Kluwer, 1998, pp. 303–27, doi:10.1023/A:1006982023657."},"title":" Metabotropic glutamate receptors are associated with non-synaptic appendages of unipolar brush cells in rat cerebellar cortex and cochlear nuclear complex","article_processing_charge":"No","external_id":{"pmid":["9923978 "]},"publist_id":"4308","author":[{"full_name":"Jaarsma, Dick","last_name":"Jaarsma","first_name":"Dick"},{"first_name":"Maria","last_name":"Diño","full_name":"Diño, Maria"},{"first_name":"Hitoshi","last_name":"Ohishi","full_name":"Ohishi, Hitoshi"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"last_name":"Mugnaini","full_name":"Mugnaini, Enrico","first_name":"Enrico"}]},{"publist_id":"4309","author":[{"last_name":"Kaupmann","full_name":"Kaupmann, Klemens","first_name":"Klemens"},{"last_name":"Malitschek","full_name":"Malitschek, Barbara","first_name":"Barbara"},{"first_name":"Valérie","last_name":"Schuler","full_name":"Schuler, Valérie"},{"last_name":"Heid","full_name":"Heid, Jacob","first_name":"Jacob"},{"first_name":"Wolfgang","last_name":"Froestl","full_name":"Froestl, Wolfgang"},{"first_name":"Pascal","last_name":"Beck","full_name":"Beck, Pascal"},{"last_name":"Mosbacher","full_name":"Mosbacher, Johannes","first_name":"Johannes"},{"first_name":"Serge","full_name":"Bischoff, Serge","last_name":"Bischoff"},{"full_name":"Kulik, Ákos","last_name":"Kulik","first_name":"Ákos"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Karschin, Andreas","last_name":"Karschin","first_name":"Andreas"},{"first_name":"Bernhard","full_name":"Bettler, Bernhard","last_name":"Bettler"}],"article_processing_charge":"No","external_id":{"pmid":["9872317"]},"title":" GABA(B)-receptor subtypes assemble into functional heteromeric complexes","citation":{"ama":"Kaupmann K, Malitschek B, Schuler V, et al. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature. 1998;396(6712):683-687. doi:10.1038/25360","apa":"Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., … Bettler, B. (1998). GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature. Nature Publishing Group. https://doi.org/10.1038/25360","ieee":"K. Kaupmann et al., “ GABA(B)-receptor subtypes assemble into functional heteromeric complexes,” Nature, vol. 396, no. 6712. Nature Publishing Group, pp. 683–687, 1998.","short":"K. Kaupmann, B. Malitschek, V. Schuler, J. Heid, W. Froestl, P. Beck, J. Mosbacher, S. Bischoff, Á. Kulik, R. Shigemoto, A. Karschin, B. Bettler, Nature 396 (1998) 683–687.","mla":"Kaupmann, Klemens, et al. “ GABA(B)-Receptor Subtypes Assemble into Functional Heteromeric Complexes.” Nature, vol. 396, no. 6712, Nature Publishing Group, 1998, pp. 683–87, doi:10.1038/25360.","ista":"Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik Á, Shigemoto R, Karschin A, Bettler B. 1998. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature. 396(6712), 683–687.","chicago":"Kaupmann, Klemens, Barbara Malitschek, Valérie Schuler, Jacob Heid, Wolfgang Froestl, Pascal Beck, Johannes Mosbacher, et al. “ GABA(B)-Receptor Subtypes Assemble into Functional Heteromeric Complexes.” Nature. Nature Publishing Group, 1998. https://doi.org/10.1038/25360."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"683 - 687","doi":"10.1038/25360","date_published":"1998-12-17T00:00:00Z","date_created":"2018-12-11T11:58:32Z","year":"1998","day":"17","publication":"Nature","quality_controlled":"1","publisher":"Nature Publishing Group","acknowledgement":"We thank D. Ristig, A. Begrich, I. Meigel and S. Leonhard for technical assistance.","date_updated":"2022-08-31T12:43:05Z","extern":"1","type":"journal_article","article_type":"original","status":"public","_id":"2588","volume":396,"issue":"6712","publication_identifier":{"issn":["0028-0836"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","month":"12","intvolume":" 396","abstract":[{"text":"B-type receptors for the neurotransmitter GABA (γ-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. Physiological and biochemical studies show that there are differences in drug efficiencies at different GABA(B) receptors, so it is expected that GABA(B)-receptor (GABA(B)R) subtypes exist. Two GABA(B)-receptor splice variants have been cloned (GABA(B)R1a and GABA(B)R1b), but native GABA(B) receptors and recombinant receptors showed unexplained differences in agonist-binding potencies. Moreover, the activation of presumed effector ion channels in heterologous cells expressing the recombinant receptors proved difficult. Here we describe a new GABA(B) receptor subtype, GABA(B)R2, which does not bind available GABA(B) antagonists with measurable potency. GABA(B)R1a, GABA(B)R1b and GABA(B)R2 alone do not activate Kir3-type potassium channels efficiently, but co- expression of these receptors yields a robust coupling to activation of Kir3 channels. We provide evidence for the assembly of heteromeric GABA(B) receptors in vivo and show that GABA(B)R2 and GABA(B)R1a/b proteins immunoprecipitate and localize together at dendritic spines. The heteromeric receptor complexes exhibit a significant increase in agonist- and partial- agonist-binding potencies as compared with individual receptors and probably represent the predominant native GABA(B) receptor. Heteromeric assembly among G-protein-coupled receptors has not, to our knowledge, been described before.\r\n","lang":"eng"}],"pmid":1,"oa_version":"None"},{"publisher":"Wiley-Blackwell","quality_controlled":"1","acknowledgement":"The authors thank Dr. Wolfgang A.A. Kunze for his helpin the English reviewing of the manuscript. The authorsthank Drs. Nadine Clerc, Jean-Pierre Kessler, WolfgangA.A. Kunze, Jean-Jacques Puizillout, and Fabien Tell fortheir constructive discussions and critiques of the manu-script. This study was supported by CNRS (FR45/UPR9024).","doi":"10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B","date_published":"1998-12-14T00:00:00Z","date_created":"2018-12-11T11:58:32Z","page":"181 - 196","day":"14","publication":"Journal of Comparative Neurology","year":"1998","title":"Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: A light and electron microscope study","publist_id":"4310","author":[{"first_name":"Agnès","last_name":"Baude","full_name":"Baude, Agnès"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"}],"external_id":{"pmid":["9845242 "]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Baude A, Shigemoto R. 1998. Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: A light and electron microscope study. Journal of Comparative Neurology. 402(2), 181–196.","chicago":"Baude, Agnès, and Ryuichi Shigemoto. “Cellular and Subcellular Distribution of Substance P Receptor Immunoreactivity in the Dorsal Vagal Complex of the Rat and Cat: A Light and Electron Microscope Study.” Journal of Comparative Neurology. Wiley-Blackwell, 1998. https://doi.org/10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B.","ama":"Baude A, Shigemoto R. Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: A light and electron microscope study. Journal of Comparative Neurology. 1998;402(2):181-196. doi:10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B","apa":"Baude, A., & Shigemoto, R. (1998). Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: A light and electron microscope study. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B","short":"A. Baude, R. Shigemoto, Journal of Comparative Neurology 402 (1998) 181–196.","ieee":"A. Baude and R. Shigemoto, “Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: A light and electron microscope study,” Journal of Comparative Neurology, vol. 402, no. 2. Wiley-Blackwell, pp. 181–196, 1998.","mla":"Baude, Agnès, and Ryuichi Shigemoto. “Cellular and Subcellular Distribution of Substance P Receptor Immunoreactivity in the Dorsal Vagal Complex of the Rat and Cat: A Light and Electron Microscope Study.” Journal of Comparative Neurology, vol. 402, no. 2, Wiley-Blackwell, 1998, pp. 181–96, doi:10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B."},"month":"12","intvolume":" 402","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"text":"Immunoreactivity for the substance P receptor (NK1 receptor) has been investigated by light and electron microscopy in the dorsal vagal complexes of adult rats and cats. The general pattern of NK1 immunoreactivity was similar for both rat and cat. Numerous NK1-immunoreactive neurons were present in the area postrema, the nucleus of the solitary tract, and the dorsal motor nucleus of the vagus nerve. The density of labelled neurons differed between the subnuclei of the nucleus of the solitary tract. Overall, the efferent neurons of the dorsal motor nucleus of the vagus nerve highly expressed NK1 when compared to neurons in the nucleus of the solitary tract. The results are discussed with reference to the viscerotopic organisation of the dorsal vagal complex. Ultrastructural analysis demonstrated that NK1 immunoreactivity was present only at the membrane surface of somatic and dendritic profiles of neurons. No labelling was found in axon terminals, axons, or glial processes. NK1 immunoreactivity, as revealed by a preembedding immunogold technique in serial ultrathin sections; was preferentially located at nonsynaptic sites. A semiquantitative study suggested that the density of NK1 receptors is statistically higher at membrane sites free of any contact (synaptic or not) with axon terminals. The subcellular localisation of NK1 immunoreactivity was similar for neurons of both rat and cat. These results suggest that in the dorsal vagal complex, substance P might act on NK1 receptors through a process of volume transmission.","lang":"eng"}],"volume":402,"issue":"2","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9967"]},"publication_status":"published","status":"public","type":"journal_article","article_type":"original","_id":"2589","extern":"1","date_updated":"2022-08-31T12:57:30Z"},{"page":"137 - 155","date_created":"2018-12-11T11:59:07Z","volume":217,"date_published":"1998-01-01T00:00:00Z","doi":"10.1090/conm/217","year":"1998","publication_status":"published","publication_identifier":{"issn":["0271-4132"]},"publication":"Advances in Differential Equations and Mathematical Physics","language":[{"iso":"eng"}],"day":"01","alternative_title":["Contemporary Mathematics"],"publisher":"American Mathematical Society","quality_controlled":"1","intvolume":" 217","month":"01","abstract":[{"lang":"eng","text":"We study a quantum particle in a random potential in two scaling limits: the low density limit (or Boltzman-Grad) and the weak coupling limit. The low density limit is the quantum analogue of the Lorentz gas. In both cases, the phase space density of the quantum evolution defined through the Wigner transform or the Husimi function converges weakly to a linear Boltz-mann equation with collision kernel given by the quantum scattering cross section. "}],"oa_version":"None","article_processing_charge":"No","publist_id":"4202","author":[{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"},{"full_name":"Yau, Horng","last_name":"Yau","first_name":"Horng"}],"title":"Linear Boltzmann equation as scaling limit of quantum Lorentz gas","citation":{"mla":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as Scaling Limit of Quantum Lorentz Gas.” Advances in Differential Equations and Mathematical Physics, vol. 217, American Mathematical Society, 1998, pp. 137–55, doi:10.1090/conm/217.","apa":"Erdös, L., & Yau, H. (1998). Linear Boltzmann equation as scaling limit of quantum Lorentz gas. In Advances in Differential Equations and Mathematical Physics (Vol. 217, pp. 137–155). American Mathematical Society. https://doi.org/10.1090/conm/217","ama":"Erdös L, Yau H. Linear Boltzmann equation as scaling limit of quantum Lorentz gas. In: Advances in Differential Equations and Mathematical Physics. Vol 217. American Mathematical Society; 1998:137-155. doi:10.1090/conm/217","ieee":"L. Erdös and H. Yau, “Linear Boltzmann equation as scaling limit of quantum Lorentz gas,” in Advances in Differential Equations and Mathematical Physics, vol. 217, American Mathematical Society, 1998, pp. 137–155.","short":"L. Erdös, H. Yau, in:, Advances in Differential Equations and Mathematical Physics, American Mathematical Society, 1998, pp. 137–155.","chicago":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as Scaling Limit of Quantum Lorentz Gas.” In Advances in Differential Equations and Mathematical Physics, 217:137–55. American Mathematical Society, 1998. https://doi.org/10.1090/conm/217.","ista":"Erdös L, Yau H. 1998.Linear Boltzmann equation as scaling limit of quantum Lorentz gas. In: Advances in Differential Equations and Mathematical Physics. Contemporary Mathematics, vol. 217, 137–155."},"date_updated":"2022-08-31T11:46:40Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","type":"book_chapter","status":"public","_id":"2695"},{"publist_id":"4163","author":[{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös"}],"article_processing_charge":"No","title":"Lifschitz tail in a magnetic field: The nonclassical regime","citation":{"short":"L. Erdös, Probability Theory and Related Fields 112 (1998) 321–371.","ieee":"L. Erdös, “Lifschitz tail in a magnetic field: The nonclassical regime,” Probability Theory and Related Fields, vol. 112, no. 3. Springer, pp. 321–371, 1998.","ama":"Erdös L. Lifschitz tail in a magnetic field: The nonclassical regime. Probability Theory and Related Fields. 1998;112(3):321-371. doi:10.1007/s004400050193","apa":"Erdös, L. (1998). Lifschitz tail in a magnetic field: The nonclassical regime. Probability Theory and Related Fields. Springer. https://doi.org/10.1007/s004400050193","mla":"Erdös, László. “Lifschitz Tail in a Magnetic Field: The Nonclassical Regime.” Probability Theory and Related Fields, vol. 112, no. 3, Springer, 1998, pp. 321–71, doi:10.1007/s004400050193.","ista":"Erdös L. 1998. Lifschitz tail in a magnetic field: The nonclassical regime. Probability Theory and Related Fields. 112(3), 321–371.","chicago":"Erdös, László. “Lifschitz Tail in a Magnetic Field: The Nonclassical Regime.” Probability Theory and Related Fields. Springer, 1998. https://doi.org/10.1007/s004400050193."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","publisher":"Springer","acknowledgement":"The author is grateful to Professor A.-S. Sznitman for explaining him his work and for fruitful discussions, and to the referee for pointing out errors and for many helpful comments.This work has been initiated and later on completed at the Forschungsinstitut für Mathematik, ETH Zürich.","page":"321 - 371","date_published":"1998-11-01T00:00:00Z","doi":"10.1007/s004400050193","date_created":"2018-12-11T11:59:17Z","year":"1998","day":"01","publication":"Probability Theory and Related Fields","article_type":"original","type":"journal_article","status":"public","_id":"2728","date_updated":"2022-08-30T08:17:54Z","extern":"1","scopus_import":"1","month":"11","intvolume":" 112","abstract":[{"lang":"eng","text":"We obtain the Lifschitz tail, i.e. the exact low energy asymptotics of the integrated density of states (IDS) of the two-dimensional magnetic Schrödinger operator with a uniform magnetic field and random Poissonian impurities. The single site potential is repulsive and it has a finite but nonzero range. We show that the IDS is a continuous function of the energy at the bottom of the spectrum. This result complements the earlier (nonrigorous) calculations by Brézin, Gross and Itzykson which predict that the IDS is discontinuous at the bottom of the spectrum for zero range (Dirac delta) impurities at low density. We also elucidate the reason behind this apparent controversy. Our methods involve magnetic localization techniques (both in space and energy) in addition to a modified version of the "enlargement of obstacles" method developed by A.-S. Sznitman."}],"oa_version":"None","volume":112,"issue":"3","publication_identifier":{"issn":["0044-3719"]},"publication_status":"published","language":[{"iso":"eng"}]},{"date_created":"2018-12-11T12:03:35Z","doi":"10.1523/JNEUROSCI.18-20-08111.1998","date_published":"1998-10-15T00:00:00Z","page":"8111 - 8125","publication":"Journal of Neuroscience","day":"15","year":"1998","oa":1,"quality_controlled":"1","publisher":"Society for Neuroscience","acknowledgement":"Supported by German Israeli Foundation Grant I 0352–073.01/94 to P.J. and Deutsche Forschungsgemeinschaft Grant Mo 432/3–1 to H.M. We thank Drs. L. Y. Jan, D. McKinnon, O. Pongs, L. Salkoff, S. H. Snyder, and J. S. Trimmer for providing plasmids, Dr. D. J. Surmeier for sharing unpublished data, and Drs. J. Bischofberger and J. R. P. Geiger for critically reading this manuscript. M.M. and J.H.S. contributed equally to this work.","title":"Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus","article_processing_charge":"No","external_id":{"pmid":["9763458"]},"author":[{"full_name":"Martina, Marco","last_name":"Martina","first_name":"Marco"},{"last_name":"Schultz","full_name":"Schultz, Jobst","first_name":"Jobst"},{"full_name":"Ehmke, Heimo","last_name":"Ehmke","first_name":"Heimo"},{"first_name":"Hannah","last_name":"Monyer","full_name":"Monyer, Hannah"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"2899","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Martina, Marco, Jobst Schultz, Heimo Ehmke, Hannah Monyer, and Peter M Jonas. “Functional and Molecular Differences between Voltage-Gated K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1998. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998.","ista":"Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. 1998. Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience. 18(20), 8111–8125.","mla":"Martina, Marco, et al. “Functional and Molecular Differences between Voltage-Gated K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.” Journal of Neuroscience, vol. 18, no. 20, Society for Neuroscience, 1998, pp. 8111–25, doi:10.1523/JNEUROSCI.18-20-08111.1998.","apa":"Martina, M., Schultz, J., Ehmke, H., Monyer, H., & Jonas, P. M. (1998). Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998","ama":"Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience. 1998;18(20):8111-8125. doi:10.1523/JNEUROSCI.18-20-08111.1998","ieee":"M. Martina, J. Schultz, H. Ehmke, H. Monyer, and P. M. Jonas, “Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus,” Journal of Neuroscience, vol. 18, no. 20. Society for Neuroscience, pp. 8111–8125, 1998.","short":"M. Martina, J. Schultz, H. Ehmke, H. Monyer, P.M. Jonas, Journal of Neuroscience 18 (1998) 8111–8125."},"volume":18,"issue":"20","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0270-6474"]},"intvolume":" 18","month":"10","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792860/"}],"scopus_import":"1","oa_version":"None","pmid":1,"abstract":[{"lang":"eng","text":"We have examined gating and pharmacological characteristics of somatic K+ channels in fast-spiking interneurons and regularly spiking principal neurons of hippocampal slices. In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4- AP) (half-maximal inhibitory concentrations <0.1 mM) predominated, contributing an average of 58% to the total K+ current in these cells. By contrast, in pyramidal neurons of the CA1 region a rapidly inactivating A- type K+ current component that was TEA-resistant prevailed, contributing 61% to the total K+ current. Both types of neurons also showed small amounts of the K+ current component mainly found in the other type of neuron and, in addition, a slow delayed rectifier K+ current component with intermediate properties (sow inactivation, intermediate sensitivity to TEA). Single-cell RT-PCR analysis of mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal neurons. In contrast, Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of pyramidal neurons but only in 55% of interneurons. Selective block of fast delayed rectifier K+ channels, presumably assembled from Kv3 subunits, by 4-AP reduced substantially the action potential frequency in interneurons. These results indicate that the differential expression of Kv3 and Kv4 subunits shapes the action potential phenotypes of principal neurons and interneurons in the cortex."}],"extern":"1","date_updated":"2022-08-29T14:20:39Z","status":"public","article_type":"original","type":"journal_article","_id":"3488"},{"date_updated":"2022-08-29T14:52:38Z","extern":"1","_id":"3487","type":"journal_article","article_type":"original","status":"public","publication_status":"published","publication_identifier":{"issn":["0036-8075"]},"language":[{"iso":"eng"}],"volume":281,"issue":"5375","abstract":[{"lang":"eng","text":"It is widely accepted that individual neurons in the central nervous system release only a single fast transmitter. The possibility of corelease of fast neurotransmitters was examined by making paired recordings from synaptically connected neurons in spinal cord slices. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron synapses consisted of a strychnine-sensitive, glycine receptor-mediated component and a bicuculline-sensitive, γ-aminobutyric acid (GABA)(A) receptor-mediated component. These results indicate that spinal interneurons release both glycine and GABA to activate functionally distinct receptors in their postsynaptic target cells. A subset of miniature synaptic currents also showed both components, consistent with corelease from individual synaptic vesicles."}],"pmid":1,"oa_version":"None","scopus_import":"1","intvolume":" 281","month":"07","citation":{"mla":"Jonas, Peter M., et al. “Corelease of Two Fast Neurotransmitters at a Central Synapse.” Science, vol. 281, no. 5375, American Association for the Advancement of Science, 1998, pp. 419–24, doi:10.1126/science.281.5375.419.","ama":"Jonas PM, Bischofberger J, Sandkühler J. Corelease of two fast neurotransmitters at a central synapse. Science. 1998;281(5375):419-424. doi:10.1126/science.281.5375.419","apa":"Jonas, P. M., Bischofberger, J., & Sandkühler, J. (1998). Corelease of two fast neurotransmitters at a central synapse. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.281.5375.419","ieee":"P. M. Jonas, J. Bischofberger, and J. Sandkühler, “Corelease of two fast neurotransmitters at a central synapse,” Science, vol. 281, no. 5375. American Association for the Advancement of Science, pp. 419–424, 1998.","short":"P.M. Jonas, J. Bischofberger, J. Sandkühler, Science 281 (1998) 419–424.","chicago":"Jonas, Peter M, Joseph Bischofberger, and Jürgen Sandkühler. “Corelease of Two Fast Neurotransmitters at a Central Synapse.” Science. American Association for the Advancement of Science, 1998. https://doi.org/10.1126/science.281.5375.419.","ista":"Jonas PM, Bischofberger J, Sandkühler J. 1998. Corelease of two fast neurotransmitters at a central synapse. Science. 281(5375), 419–424."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["9665886 "]},"article_processing_charge":"No","author":[{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Joseph","full_name":"Bischofberger, Joseph","last_name":"Bischofberger"},{"first_name":"Jürgen","full_name":"Sandkühler, Jürgen","last_name":"Sandkühler"}],"publist_id":"2900","title":"Corelease of two fast neurotransmitters at a central synapse","year":"1998","publication":"Science","day":"17","page":"419 - 424","date_created":"2018-12-11T12:03:35Z","date_published":"1998-07-17T00:00:00Z","doi":"10.1126/science.281.5375.419","acknowledgement":"See comment by Nicoll RA, Malenka RC (1998) Science 281:360-361\r\n","quality_controlled":"1","publisher":"American Association for the Advancement of Science"}]