---
_id: '3756'
abstract:
- lang: eng
text: 'In many eukaryotic cells going through M-phase, a bipolar spindle is formed
by microtubules nucleated from centrosomes. These microtubules, in addition to
being `''captured” by kinetochores, may be stabilized by chromatin in two different
ways: short-range stabilization effects may affect microtubules in close contact
with the chromatin, while long-range stabilization effects may `''guide” microtubule
growth towards the chromatin (e.g., by introducing a diffusive gradient of an
enzymatic activity that affects microtubule assembly). Here, we use both meiotic
and mitotic extracts from Xenopus laevis eggs to study microtubule aster formation
and microtubule dynamics in the presence of chromatin. In `''low-speed” meiotic
extracts, in the presence of salmon sperm chromatin, we find that short-range
stabilization effects lead to a strong anisotropy of the microtubule asters. Analysis
of the dynamic parameters of microtubule growth shows that this anisotropy arises
from a decrease in the catastrophe frequency, an increase in the rescue frequency
and a decrease in the growth velocity. In this system we also find evidence for
long-range `''guidance” effects, which lead to a weak anisotropy of the asters.
Statistically relevant results on these long-range effects are obtained in `''high-speed”
mitotic extracts in the presence of artificially constructed chromatin stripes.
We find that aster anisotropy is biased in the direction of the chromatin and
that the catastrophe frequency is reduced in its vicinity. In this system we also
find a surprising dependence of the catastrophe and the rescue frequencies on
the length of microtubules nucleated from centrosomes: the catastrophe frequency
increases and the rescue frequency decreases with microtubule length.'
acknowledgement: "We would like to thank T. Holy and T. Mitchison for providing us
with centrosomes; M. Glotzer and T. Mitchison for giving us the plasmid for A90
cyclin B; J. Stock and members of his laboratory for help with biochemical preparations;
R. Zimmerman for help with the biotinylation of DNA; J. Shepard for help with the
patterning of surfaces; D. Tsui for use\r\nof his clean room facility, and D. Fygenson,
T. Holy, E. Karsenti, E. Kennedy, A. Levine, T. Mitchison, and G. Waters for valuable
discussions, constant encouragement and technical help. This work was partially
supported by the National Institutes of Health (Grant No. GM-50712) and the Human
Frontier Science Program."
article_processing_charge: No
article_type: original
author:
- first_name: Marileen
full_name: Dogterom, Marileen
last_name: Dogterom
- first_name: M.
full_name: Felix, M.
last_name: Felix
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: 'Dogterom M, Felix M, Guet CC, Leibler S. Influence of M-phase chromatin on
the anisotropy of microtubule asters. Journal of Cell Biology. 1996;133(1):125-140.
doi:doi: 10.1083/jcb.133.1.125
'
apa: 'Dogterom, M., Felix, M., Guet, C. C., & Leibler, S. (1996). Influence
of M-phase chromatin on the anisotropy of microtubule asters. Journal of Cell
Biology. Rockefeller University Press. https://doi.org/doi: 10.1083/jcb.133.1.125 '
chicago: 'Dogterom, Marileen, M. Felix, Calin C Guet, and Stanislas Leibler. “Influence
of M-Phase Chromatin on the Anisotropy of Microtubule Asters.” Journal of Cell
Biology. Rockefeller University Press, 1996. https://doi.org/doi: 10.1083/jcb.133.1.125 .'
ieee: M. Dogterom, M. Felix, C. C. Guet, and S. Leibler, “Influence of M-phase chromatin
on the anisotropy of microtubule asters,” Journal of Cell Biology, vol.
133, no. 1. Rockefeller University Press, pp. 125–140, 1996.
ista: Dogterom M, Felix M, Guet CC, Leibler S. 1996. Influence of M-phase chromatin
on the anisotropy of microtubule asters. Journal of Cell Biology. 133(1), 125–140.
mla: 'Dogterom, Marileen, et al. “Influence of M-Phase Chromatin on the Anisotropy
of Microtubule Asters.” Journal of Cell Biology, vol. 133, no. 1, Rockefeller
University Press, 1996, pp. 125–40, doi:doi: 10.1083/jcb.133.1.125 .'
short: M. Dogterom, M. Felix, C.C. Guet, S. Leibler, Journal of Cell Biology 133
(1996) 125–140.
date_created: 2018-12-11T12:05:00Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-09T14:20:13Z
day: '01'
doi: 'doi: 10.1083/jcb.133.1.125 '
extern: '1'
external_id:
pmid:
- '8601601'
intvolume: ' 133'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120784/
month: '01'
oa: 1
oa_version: Published Version
page: 125 - 140
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '2473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of M-phase chromatin on the anisotropy of microtubule asters
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 133
year: '1996'
...
---
_id: '4027'
abstract:
- lang: eng
text: 'Questions about lines in space arise frequently as subproblems in three-dimensional
computational geometry. In this paper we study a number of fundamental combinatorial
and algorithmic problems involving arrangements of n lines in three-dimensional
space. Our main results include: 1. A tight Θ(n2) bound on the maximum combinatorial
description complexity of the set of all oriented lines that have specified orientations
relative to the n given lines. 2. A similar bound of Θ(n3) for the complexity
of the set of all lines passing above the n given lines. 3. A preprocessing procedure
using O(n2+ε) time and storage, for any ε > 0, that builds a structure supporting
O(logn)-time queries for testing if a line lies above all the given lines. 4.
An algorithm that tests the "towering property" in O(n4/3+ε) time, for
any ε > 0: do n given red lines lie all above n given blue lines? The tools
used to obtain these and other results include Plücker coordinates for lines in
space and ε-nets for various geometric range spaces.'
acknowledgement: Work on this paper by Bernard Chazelle has been supported by NSF
Grant CCR-87-00917. Work on this paper by Herbert Edelsbrunner has been supported
by NSF Grant CCR-87-14565. Work on this paper by Leonidas Guibas has been supported
by grants from the Mitsubishi and Toshiba Corporations. Work on this paper by Micha
Sharir has been supported by ONR Grant N00014-87-K-0129, by NSF Grants DCR-83-20085
and CCR-89-01484, and by grants from the U.S.-Israeli Binational Science Foundation,
the NCRD — the Israeli National Council for Research and Development, and the EMET
Fund of the Israeli Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jorge
full_name: Stolfi, Jorge
last_name: Stolfi
citation:
ama: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. Lines in space:
Combinatorics and algorithms. Algorithmica. 1996;15(5):428-447. doi:10.1007/BF01955043'
apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., & Stolfi, J. (1996).
Lines in space: Combinatorics and algorithms. Algorithmica. Springer. https://doi.org/10.1007/BF01955043'
chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
and Jorge Stolfi. “Lines in Space: Combinatorics and Algorithms.” Algorithmica.
Springer, 1996. https://doi.org/10.1007/BF01955043.'
ieee: 'B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Stolfi, “Lines
in space: Combinatorics and algorithms,” Algorithmica, vol. 15, no. 5.
Springer, pp. 428–447, 1996.'
ista: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. 1996. Lines in
space: Combinatorics and algorithms. Algorithmica. 15(5), 428–447.'
mla: 'Chazelle, Bernard, et al. “Lines in Space: Combinatorics and Algorithms.”
Algorithmica, vol. 15, no. 5, Springer, 1996, pp. 428–47, doi:10.1007/BF01955043.'
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Stolfi, Algorithmica
15 (1996) 428–447.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-05-01T00:00:00Z
date_updated: 2022-08-09T09:55:46Z
day: '01'
doi: 10.1007/BF01955043
extern: '1'
intvolume: ' 15'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 428 - 447
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2100'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lines in space: Combinatorics and algorithms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4026'
abstract:
- lang: eng
text: A set of n weighted points in general position in R(d) defines a unique regular
triangulation. This paper proves that if the points are added one by one, then
flipping in a topological order will succeed in constructing this triangulation.
If, in addition, the points are added in a random sequence and the history of
the flips is used for locating the next point, then the algorithm takes expected
time at most O(n log n + n(inverted left perpendicular d/2 inverted right perpendicular)).
Under the assumption that the points and weights are independently and identically
distributed, the expected running time is between proportional to and a factor
log n more than the expected size of the regular triangulation. The expectation
is over choosing the points and over independent coin-flips performed by the algorithm.
acknowledgement: National Science Foundation under Grant CCR-8921421, Alan T. Waterman
award, Grant CCR-9118874.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Nimish
full_name: Shah, Nimish
last_name: Shah
citation:
ama: Edelsbrunner H, Shah N. Incremental topological flipping works for regular
triangulations. Algorithmica. 1996;15(3):223-241. doi:10.1007/BF01975867
apa: Edelsbrunner, H., & Shah, N. (1996). Incremental topological flipping works
for regular triangulations. Algorithmica. Springer. https://doi.org/10.1007/BF01975867
chicago: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping
Works for Regular Triangulations.” Algorithmica. Springer, 1996. https://doi.org/10.1007/BF01975867.
ieee: H. Edelsbrunner and N. Shah, “Incremental topological flipping works for regular
triangulations,” Algorithmica, vol. 15, no. 3. Springer, pp. 223–241, 1996.
ista: Edelsbrunner H, Shah N. 1996. Incremental topological flipping works for regular
triangulations. Algorithmica. 15(3), 223–241.
mla: Edelsbrunner, Herbert, and Nimish Shah. “Incremental Topological Flipping Works
for Regular Triangulations.” Algorithmica, vol. 15, no. 3, Springer, 1996,
pp. 223–41, doi:10.1007/BF01975867.
short: H. Edelsbrunner, N. Shah, Algorithmica 15 (1996) 223–241.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-03-01T00:00:00Z
date_updated: 2022-08-09T09:46:07Z
day: '01'
doi: 10.1007/BF01975867
extern: '1'
intvolume: ' 15'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 223 - 241
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2099'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Incremental topological flipping works for regular triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4030'
acknowledgement: article M-Pos412
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: Liang J, Edelsbrunner H, Subramaniam S. Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations. Vol 70.
Cell Press; 1996:A224-A224. doi:10.1016/S0006-3495(96)79664-9
apa: Liang, J., Edelsbrunner, H., & Subramaniam, S. (1996). Effects of molecular
shape representations on boundary element method for protein electrostatics computations.
Fortieth Annual Meeting (Vol. 70, pp. A224–A224). Cell Press. https://doi.org/10.1016/S0006-3495(96)79664-9
chicago: Liang, Jie, Herbert Edelsbrunner, and Shankar Subramaniam. Effects of
Molecular Shape Representations on Boundary Element Method for Protein Electrostatics
Computations. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79664-9.
ieee: J. Liang, H. Edelsbrunner, and S. Subramaniam, Effects of molecular shape
representations on boundary element method for protein electrostatics computations,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A224–A224.
ista: Liang J, Edelsbrunner H, Subramaniam S. 1996. Effects of molecular shape representations
on boundary element method for protein electrostatics computations, Cell Press,p.
mla: Liang, Jie, et al. “Effects of Molecular Shape Representations on Boundary
Element Method for Protein Electrostatics Computations.” Fortieth Annual Meeting,
vol. 70, no. 2, Part 2, Cell Press, 1996, pp. A224–A224, doi:10.1016/S0006-3495(96)79664-9.
short: J. Liang, H. Edelsbrunner, S. Subramaniam, Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations, Cell Press,
1996.
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-19T00:00:00Z
date_updated: 2022-08-08T10:22:38Z
day: '19'
doi: 10.1016/S0006-3495(96)79664-9
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796649?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A224 - A224
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2097'
status: public
title: Effects of molecular shape representations on boundary element method for protein
electrostatics computations
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4031'
acknowledgement: article W-AM-L6
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sudhakar
full_name: Pamidghantam, Sudhakar
last_name: Pamidghantam
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets. Vol 70.
Cell Press; 1996:A377-A377. doi:10.1016/S0006-3495(96)79670-4'
apa: 'Liang, J., Edelsbrunner, H., Pamidghantam, S., & Subramaniam, S. (1996).
Analytical method for molecular shapes: Area, volume, cavities, interface and
pockets. Fortieth Annual Meeting (Vol. 70, pp. A377–A377). Cell Press.
https://doi.org/10.1016/S0006-3495(96)79670-4'
chicago: 'Liang, Jie, Herbert Edelsbrunner, Sudhakar Pamidghantam, and Shankar Subramaniam.
Analytical Method for Molecular Shapes: Area, Volume, Cavities, Interface and
Pockets. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79670-4.'
ieee: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, and S. Subramaniam, Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A377–A377.'
ista: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. 1996. Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets, Cell
Press,p.'
mla: 'Liang, Jie, et al. “Analytical Method for Molecular Shapes: Area, Volume,
Cavities, Interface and Pockets.” Fortieth Annual Meeting, vol. 70, no.
2, Part 2, Cell Press, 1996, pp. A377–A377, doi:10.1016/S0006-3495(96)79670-4.'
short: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, S. Subramaniam, Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets, Cell Press,
1996.'
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-21T00:00:00Z
date_updated: 2022-08-08T10:21:56Z
day: '21'
doi: 10.1016/S0006-3495(96)79670-4
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796704?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A377 - A377
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2098'
status: public
title: 'Analytical method for molecular shapes: Area, volume, cavities, interface
and pockets'
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4142'
abstract:
- lang: eng
text: 'Mutations giving rise to anatomical defects in the inner ear have been isolated
in a large scale screen for mutations causing visible abnormalities in the zebrafish
embryo (Haffter, P., Granato, M., Brand, M. et al. (1996) Development 123, 1-36).
58 mutants have been classified as having a primary ear phenotype; these fall
into several phenotypic classes, affecting presence or size of the otoliths, size
and shape of the otic vesicle and formation of the semicircular canals, and define
at least 20 complementation groups. Mutations in seven genes cause loss of one
or both otoliths, but do not appear to affect development of other structures
within the ear. Mutations in seven genes affect morphology and patterning of the
inner ear epithelium, including formation of the semicircular canals and, in some,
development of sensory patches (maculae and cristae). Within this class, dog-eared
mutants show abnormal development of semicircular canals and lack cristae within
the ear, while in van gogh, semicircular canals fail to form altogether, resulting
in a tiny otic vesicle containing a single sensory patch. Both these mutants show
defects in the expression of homeobox genes within the otic vesicle. In a further
class of mutants, ear size is affected while patterning appears to be relatively
normal; mutations in three genes cause expansion of the otic vesicle, while in
little ears and microtic, the ear is abnormally small, but still contains all
five sensory patches, as in the wild type. Many of the ear and otolith mutants
show an expected behavioural phenotype: embryos fail to balance correctly, and
may swim on their sides, upside down, or in circles. Several mutants with similar
balance defects have also been isolated that have no obvious structural ear defect,
but that may include mutants with vestibular dysfunction of the inner ear (Granato,
M., van Eeden, F. J. M., Schach, U. et al. (1996) Development, 123, 399-413,).
Mutations in 19 genes causing primary defects in other structures also show an
ear defect. In particular, ear phenotypes are often found in conjunction with
defects of neural crest derivatives (pigment cells and/or cartilaginous elements
of the jaw). At least one mutant, dog-eared, shows defects in both the ear and
another placodally derived sensory system, the lateral line, while hypersensitive
mutants have additional trunk lateral line organs.'
acknowledgement: T. T. W. thanks all members of the Tübingen fish and fly groups for
their hospitality and generosity during her visits to the laboratory. We thank Julian
Lewis, in whose laboratory much of this work was carried out, for many helpful discussions
and suggestions, Catherine Haddon for advice on wild-type ear development and techniques,
and Stephen Massey for fish husbandry in Oxford. We are grateful to Julian Lewis,
Catherine Haddon, Nick Monk and Patrick Blader for comments on the manuscript, and
to Trevor Jowett, Tom Schilling,Eric Weinberg and Monte Westerfield for providing
cDNAs. We also thank Jarema Malicki and Wolfgang Driever for making some of the
Boston otolith mutants available before publication. T. T. W. thanks the EMBO (ASTF
7668; ASTF 7918), the Imperial Cancer Research Fund and the Wellcome Trust (03643/Z/92)
for support.
article_processing_charge: No
article_type: original
author:
- first_name: Tanya
full_name: Whitfield, Tanya
last_name: Whitfield
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Whitfield T, Granato M, Van Eeden F, et al. Mutations affecting development
of the zebrafish inner ear and lateral line. Development. 1996;123:241-254.
doi:10.1242/dev.123.1.241
apa: Whitfield, T., Granato, M., Van Eeden, F., Schach, U., Brand, M., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting development of the
zebrafish inner ear and lateral line. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.241
chicago: Whitfield, Tanya, Michael Granato, Fredericus Van Eeden, Ursula Schach,
Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Mutations Affecting
Development of the Zebrafish Inner Ear and Lateral Line.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.241.
ieee: T. Whitfield et al., “Mutations affecting development of the zebrafish
inner ear and lateral line,” Development, vol. 123. Company of Biologists,
pp. 241–254, 1996.
ista: Whitfield T, Granato M, Van Eeden F, Schach U, Brand M, Furutani Seiki M,
Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the
zebrafish inner ear and lateral line. Development. 123, 241–254.
mla: Whitfield, Tanya, et al. “Mutations Affecting Development of the Zebrafish
Inner Ear and Lateral Line.” Development, vol. 123, Company of Biologists,
1996, pp. 241–54, doi:10.1242/dev.123.1.241.
short: T. Whitfield, M. Granato, F. Van Eeden, U. Schach, M. Brand, M. Furutani
Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 241–254.
date_created: 2018-12-11T12:07:11Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:45:59Z
day: '01'
doi: 10.1242/dev.123.1.241
extern: '1'
external_id:
pmid:
- '9007244'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 241 - 254
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1979'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the zebrafish inner ear and lateral line
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4154'
abstract:
- lang: eng
text: As part of a large scale chemical mutagenesis screen of the zebrafish (Danio
rerio) genome, we have identified 33 mutants with defects in hematopoiesis, Complementation
analysis placed 32 of these mutants into 17 complementation groups, The allelism
of the remaining 1 blood mutant is currently unresolved, We have categorized these
blood mutants into four phenotypic classes based on analyses of whole embryos
and isolated blood cells, as well as by in situ hybridization using the hematopoietic
transcription factors GATA-1 and GATA-2, Embryos mutant for the gene moonshine
have few if any proerythroblasts visible on the day circulation begins and normal
erythroid cell differentiation is blocked as determined by staining for hemoglobin
and GATA-1 expression, Mutations in five genes, chablis, frascati, merlot, retsina,
thunderbird and two possibly unique mutations cause a progressive decrease in
the number of blood cells during the first 5 days of development, Mutations in
another seven genes, chardonnay, chianti, grenache, sauternes, weibherbst and
zinfandel, and two additional mutations result in hypochromic blood cells which
also decrease in number as development proceeds, Several of these mutants have
immature cells in the circulation, indicating a block in normal erythroid development.
The mutation in zinfandel is dominant, and 2-day old heterozygous carriers fail
to express detectable levels of hemoglobin and have decreasing numbers of circulating
cells during the first 5 days of development, Mutations in two genes, freixenet
and yquem, result in the animals that are photosensitive with autofluorescent
blood, similar to that found in the human congenital porphyrias, The collection
of mutants presented here represent several steps required for normal erythropoiesis,
The analysis of these mutants provides a powerful approach towards defining the
molecular mechanisms involved in vertebrate hematopoietic development.
acknowledgement: 'We thank Leonard Zon for his generous support of D. G. R. and A.
B., for critical review of this manuscript and for many helpful discussions. We
also thank Lauren Barone and Stephen Pratt for technical assistance. D. G. R. is
a postdoctoral fellow of the Howard Hughes Medical Institute. '
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Ransom, David
last_name: Ransom
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Alison
full_name: Brownlie, Alison
last_name: Brownlie
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Ransom D, Haffter P, Odenthal J, et al. Characterization of zebrafish mutants
with defects in embryonic hematopoiesis. Development. 1996;123(1):311-319.
doi:10.1242/dev.123.1.311
apa: Ransom, D., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh,
R., … Nüsslein Volhard, C. (1996). Characterization of zebrafish mutants with
defects in embryonic hematopoiesis. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.311
chicago: Ransom, David, Pascal Haffter, Jörg Odenthal, Alison Brownlie, Elisabeth
Vogelsang, Robert Kelsh, Michael Brand, et al. “Characterization of Zebrafish
Mutants with Defects in Embryonic Hematopoiesis.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.311.
ieee: D. Ransom et al., “Characterization of zebrafish mutants with defects
in embryonic hematopoiesis,” Development, vol. 123, no. 1. Company of Biologists,
pp. 311–319, 1996.
ista: Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, Brand M,
Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang
Y, Kane D, Mullins M, Nüsslein Volhard C. 1996. Characterization of zebrafish
mutants with defects in embryonic hematopoiesis. Development. 123(1), 311–319.
mla: Ransom, David, et al. “Characterization of Zebrafish Mutants with Defects in
Embryonic Hematopoiesis.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 311–19, doi:10.1242/dev.123.1.311.
short: D. Ransom, P. Haffter, J. Odenthal, A. Brownlie, E. Vogelsang, R. Kelsh,
M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J.
Heisenberg, Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123
(1996) 311–319.
date_created: 2018-12-11T12:07:16Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:23:35Z
day: '01'
doi: 10.1242/dev.123.1.311
extern: '1'
external_id:
pmid:
- '9007251'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 311 - 319
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1966'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Characterization of zebrafish mutants with defects in embryonic hematopoiesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4156'
abstract:
- lang: eng
text: 'In a large scale screen for mutants that affect the early development of
the zebrafish, 109 mutants were found that cause defects in the formation of the
jaw and the more posterior pharyngeal arches, Here we present the phenotypic description
and results of the complementation analysis of mutants belonging to two major
classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants
with defects in cartilage differentiation and growth in all arches, Mutations
in four of the genes identified during the screen show specific defects in the
first two arches and leave the more posterior pharyngeal arches largely unaffected
(schmerle, sucker, hoover and sturgeon). In these mutants ventral components of
the mandibular and hyoid arches are reduced (Meckel''s cartilage and ceratohyal
cartilage) whereas dorsal structures (palato-quadrate and hyosymplectic cartilages)
are of normal size or enlarged, Thus, mutations in single genes cause defects
in the formation of first and second arch structures but also differentially affect
development of the dorsal and ventral structures within one arch. In 27 mutants
that define at least 8 genes, the differentiation of cartilage and growth is affected.
In hammerhead mutants particularly the mesodermally derived cartilages are reduced,
whereas jellyfish mutant larvae are characterized by a severe reduction of all
cartilaginous elements, leaving only two pieces in the position of the ceratohyal
cartilages. In all other mutant larvae all skeletal elements are present, but
consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened
heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths
of chondrocytes occur along the edges of all cartilaginous elements. The mutants
presented here may be valuable tools for elucidating the genetic mechanisms that
underlie the development of the mandibular and the hyoid arches, as well as the
process of cartilage differentiation.'
acknowledgement: We would like to thank Siegfried Roth, Stefan Schulte-Merker and
Tanya Whitfield for critically reading the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Piotrowski T, Schilling T, Brand M, et al. Jaw and branchial arch mutants
in zebrafish II: Anterior arches and cartilage differentiation. Development.
1996;123(1):345-356. doi:10.1242/dev.123.1.345'
apa: 'Piotrowski, T., Schilling, T., Brand, M., Jiang, Y., Heisenberg, C.-P. J.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in
zebrafish II: Anterior arches and cartilage differentiation. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.345'
chicago: 'Piotrowski, Tatjana, Thomas Schilling, Michael Brand, Yunjin Jiang, Carl-Philipp
J Heisenberg, Dirk Beuchle, Heiner Grandel, et al. “Jaw and Branchial Arch Mutants
in Zebrafish II: Anterior Arches and Cartilage Differentiation.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.345.'
ieee: 'T. Piotrowski et al., “Jaw and branchial arch mutants in zebrafish
II: Anterior arches and cartilage differentiation,” Development, vol. 123,
no. 1. Company of Biologists, pp. 345–356, 1996.'
ista: 'Piotrowski T, Schilling T, Brand M, Jiang Y, Heisenberg C-PJ, Beuchle D,
Grandel H, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996.
Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation. Development. 123(1), 345–356.'
mla: 'Piotrowski, Tatjana, et al. “Jaw and Branchial Arch Mutants in Zebrafish II:
Anterior Arches and Cartilage Differentiation.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 345–56, doi:10.1242/dev.123.1.345.'
short: T. Piotrowski, T. Schilling, M. Brand, Y. Jiang, C.-P.J. Heisenberg, D. Beuchle,
H. Grandel, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt,
D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development
123 (1996) 345–356.
date_created: 2018-12-11T12:07:17Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:13:07Z
day: '01'
doi: 10.1242/dev.123.1.345
extern: '1'
external_id:
pmid:
- '9007254 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 345 - 356
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1963'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4191'
abstract:
- lang: eng
text: In a screen for embryonic mutants in the zebrafish a large number of mutants
were isolated with abnormal brain morphology, We describe here 26 mutants in 13
complementation groups that show abnormal development of large regions of the
brain, Early neurogenesis is affected in white tail (wit), During segmentation
stages, homozygous wit embryos display an irregularly formed neural keel, particularly
in the hindbrain, Using a variety of molecular markers, a severe increase in the
number of various early differentiating neurons can be demonstrated, In contrast,
late differentiating neurons, radial glial cells and some nonneural cell types,
such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis
appears delayed, In addition, very reduced numbers of melanophores are present
posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants
in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general
organization of the hindbrain is disturbed and many rounded cells accumulate loosely
in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk),
natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop
collapsed brain ventricles, before showing signs of general degeneration, atlantis
(atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele)
mutants have different malformation of the brain folds, Some of them have transient
phenotypes, and mutant individuals may grow up to adults.
acknowledgement: We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield,
Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse
Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan
and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants
to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J.
J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).
article_processing_charge: No
article_type: original
author:
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis
and brain morphology in the zebrafish, Danio rerio. Development. 1996;123(1):205-216.
doi:10.1242/dev.123.1.205
apa: Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M.,
Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and
brain morphology in the zebrafish, Danio rerio. Development. Company of
Biologists. https://doi.org/10.1242/dev.123.1.205
chicago: Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle,
Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting
Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.205.
ieee: Y. Jiang et al., “Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 205–216, 1996.
ista: Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga
R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio. Development. 123(1), 205–216.
mla: Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 205–16, doi:10.1242/dev.123.1.205.
short: Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R.
Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins,
J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.
date_created: 2018-12-11T12:07:30Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:13:51Z
day: '01'
doi: 10.1242/dev.123.1.205
extern: '1'
external_id:
pmid:
- '9007241'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 205 - 216
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4186'
abstract:
- lang: eng
text: 'Neural crest development involves cell-fate specification, proliferation,
patterned cell migration, survival and differentiation, Zebrafish neural crest
derivatives include three distinct chromatophores, which are well-suited to genetic
analysis of their development, As part of a large-scale mutagenesis screen for
embryonic/early larval mutations, we have isolated 285 mutations affecting all
aspects of zebrafish larval pigmentation, By complementation analysis, we define
94 genes, We show here that comparison of their phenotypes permits classification
of these mutations according to the types of defects they cause, and these suggest
which process of neural crest development is probably affected, Mutations in eight
genes affect the number of chromatophores: these include strong candidates for
genes necessary for the processes of pigment cell specification and proliferation,
Mutations in five genes remove part of the wild-type pigment pattern, and suggest
a role in larval pigment pattern formation, Mutations in five genes show ectopic
chromatophores in distinct sites, and may have implications for chromatophore
patterning and proliferation, 76 genes affect pigment or morphology of one or
more chromatophore types: these mutations include strong candidates for genes
important in various aspects of chromatophore differentiation and survival, In
combination with the embryological advantages of zebrafish, these mutations should
permit cellular and molecular dissection of many aspects of neural crest development.'
acknowledgement: We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and
Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral
Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Lisa
full_name: Vogelsang, Lisa
last_name: Vogelsang
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the
processes of neural crest development. Development. 1996;123(1):369-389.
doi:10.1242/dev.123.1.369
apa: Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P.,
… Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes
of neural crest development. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.369
chicago: Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg,
Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations
and the Processes of Neural Crest Development.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.369.
ieee: R. Kelsh et al., “Zebrafish pigmentation mutations and the processes
of neural crest development,” Development, vol. 123, no. 1. Company of
Biologists, pp. 369–389, 1996.
ista: Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J,
Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D,
Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation
mutations and the processes of neural crest development. Development. 123(1),
369–389.
mla: Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of
Neural Crest Development.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 369–89, doi:10.1242/dev.123.1.369.
short: R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J.
Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development
123 (1996) 369–389.
date_created: 2018-12-11T12:07:28Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T11:16:49Z
day: '01'
doi: 10.1242/dev.123.1.369
extern: '1'
external_id:
pmid:
- '9007256 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 369 - 389
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1933'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zebrafish pigmentation mutations and the processes of neural crest development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4189'
abstract:
- lang: eng
text: 'This report describes mutants of the zebrafish having phenotypes causing
a general arrest in early morphogenesis. These mutants identify a group of loci
making up about 20% of the loci identified by mutants with visible morphological
phenotypes within the first day of development. There are 12 Class I mutants,
which fall into 5 complementation groups and have cells that lyse before morphological
defects are observed. Mutants at three loci, speed bump, ogre and zombie, display
abnormal nuclei. The 8 Class II mutants, which fall into 6 complementation groups,
arrest development before cell lysis is observed. These mutants seemingly stop
development in the late segmentation stages, and maintain a body shape similar
to a 20 hour embryo. Mutations in speed bump, ogre, zombie, specter, poltergeist
and troll were tested for cell lethality by transplanting mutant cells into wild-type
hosts. With poltergeist, transplanted mutant cells all survive. The remainder
of the mutants tested were autonomously but conditionally lethal: mutant cells,
most of which lyse, sometimes survive to become notochord, muscles, or, in rare
cases, large neurons, all cell types which become postmitotic in the gastrula.
Some of the genes of the early arrest group may be necessary for progression though
the cell cycle; if so, the survival of early differentiating cells may be based
on having their terminal mitosis before the zygotic requirement for these genes.'
acknowledgement: We thank Dr Adam Felsenfeld for his careful comments on earlier drafts
of this manuscript, D. A. K. also thanks the two anonymous referees who patiently
pointed out a number of ‘speed bumps’ in the first submitted draft of this manuscript.
This work was supported in part by a grant from the National Institutes of Health
to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Maischein H, Brand M, et al. The zebrafish early arrest mutants. Development.
1996;123(1):57-66. doi:10.1242/dev.123.1.57
apa: Kane, D., Maischein, H., Brand, M., Van Eeden, F., Furutani Seiki, M., Granato,
M., … Nüsslein Volhard, C. (1996). The zebrafish early arrest mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.57
chicago: Kane, Donald, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto
Furutani Seiki, Michael Granato, Pascal Haffter, et al. “The Zebrafish Early Arrest
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.57 .
ieee: D. Kane et al., “The zebrafish early arrest mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 57–66, 1996.
ista: Kane D, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kelsh R, Mullins M, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish early arrest mutants. Development.
123(1), 57–66.
mla: Kane, Donald, et al. “The Zebrafish Early Arrest Mutants.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 57–66, doi:10.1242/dev.123.1.57 .
short: D. Kane, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 57–66.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:43:44Z
day: '01'
doi: '10.1242/dev.123.1.57 '
extern: '1'
external_id:
pmid:
- '9007229 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 57 - 66
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish early arrest mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4188'
abstract:
- lang: eng
text: 'Epiboly, the enveloping of the yolk cell by the blastoderm, is the first
zebrafish morphogenetic movement, We isolated four mutations that affect epiboly:
half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal
progress of the deep cells of the blastoderm; only the yolk syncytial layer of
the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole
of the embryo, The mutations half baked, avalanche and lawine produce a novel
dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos
produced from heterozygous females slow down epiboly and accumulate detached cells
over the neural tube; a small fraction of these mutant individuals are viable,
Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type
females complete epiboly normally and are completely viable. Additionally, embryos
heterozygous for half baked have an enlarged hatching gland, a partial dominant
phenotype, The phenotypes of these mutants demonstrate that, for the spreading
of cells during epiboly, the movement of the deep cells of the blastoderm require
the function of genes that are not necessary for the movement of the enveloping
layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes
illustrate the maternal and zygotic interplay of genes that orchestrate the early
cell movements of the zebrafish.'
acknowledgement: We thank Drs John Postlethwait and Sigfreid Roth for their helpful
comments on earlier drafts of this paper. This work was supported in part by a grant
from the National Institutes of Health to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. Development.
1996;123(1):47-55. doi:10.1242/dev.123.1.47
apa: Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.47
chicago: Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.47 .
ieee: D. Kane et al., “The zebrafish epiboly mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.
ista: Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development.
123(1), 47–55.
mla: Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:10.1242/dev.123.1.47 .
short: D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:22:40Z
day: '01'
doi: '10.1242/dev.123.1.47 '
extern: '1'
external_id:
pmid:
- '9007228 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 47 - 55
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1930'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish epiboly mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4203'
abstract:
- lang: eng
text: 'We identified four zebrafish mutants with defects in forebrain induction
and patterning during embryogenesis. The four mutants define three genes: masterblind
(mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain
acquires posterior forebrain characteristics: anterior structures such as the
eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis
located in the posterior forebrain is expanded, In slb embryos, the extension
of the embryonic axis is initially delayed and eventually followed by a partial
fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia
is incomplete and dorsal midline cells fail to form a differentiated roof plate,
Analysis of the mutant phenotypes indicates that we have identified genes essential
for the specification of the anterior forebrain (mbl), positioning of the eyes
(slb) and differentiation of the roof plate (kas). In an appendix to this study
we list mutants showing alterations in the size of the eyes and abnormal differentiation
of the lenses.'
acknowledgement: We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b
cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and
V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for
help with the initial characterization of the mbl phenotype and many valuable comments
on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan,
Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of
the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development
in the zebrafish, Danio rerio. Development. 1996;123:191-203. doi:10.1242/dev.123.1.191
apa: Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in
the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.191
chicago: Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga,
Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved
in Forebrain Development in the Zebrafish, Danio Rerio.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.191
.
ieee: C.-P. J. Heisenberg et al., “Genes involved in forebrain development
in the zebrafish, Danio rerio,” Development, vol. 123. Company of Biologists,
pp. 191–203, 1996.
ista: Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish,
Danio rerio. Development. 123, 191–203.
mla: Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development
in the Zebrafish, Danio Rerio.” Development, vol. 123, Company of Biologists,
1996, pp. 191–203, doi:10.1242/dev.123.1.191
.
short: C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.
date_created: 2018-12-11T12:07:34Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T08:06:15Z
day: '01'
doi: '10.1242/dev.123.1.191 '
extern: '1'
external_id:
pmid:
- '9007240 '
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 191 - 203
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes involved in forebrain development in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4216'
abstract:
- lang: eng
text: Tissues of the dorsal midline of vertebrate embryos, such as notochord and
floor plate, have been implicated in inductive interactions that pattern the neural
tube and somites. In our screen for embryonic visible mutations in the zebrafish
we found 113 mutations in more than 27 genes with altered body shape, often with
additional defects in CNS development. We concentrated on a subgroup of mutations
in ten genes (the midline-group) that cause defective development of the floor
plate. By using floor plate markers, such as the signaling molecule sonic hedgehog,
we show that the schmalspur (sur) gene is needed for early floor plate development,
similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene.
In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted
to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In
the underlying mesendodermal tissue of the head, sur is needed only for development
of the posterior prechordal plate, whereas oep and eye are required for both anterior
and posterior prechordal plate development. Our analysis of sur mutants suggests
that defects within the posterior prechordal plate may cause aberrant development
of ventral CNS structures in the mid- and hindbrain. Later development of the
floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour,
schmalkars and monorail embryos; these mutants often show additional defects in
tissues that are known to depend on signals from notochord and floor plate, For
example, sur, con, and yot mutants show reduction of motor neurons; median deletions
of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and
dtr mutants often show no or abnormal formation of the optic chiasm. We also find
fusions of the ventral neurocranium for all midline mutants tested, which may
reveal a hitherto unrecognized function of the midline in influencing differentiation
of neural crest cells at their destination. As a working hypothesis, we propose
that midline-group genes may act to maintain proper structure and inductive function
of zebrafish midline tissues.
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss
and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg
and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript,
his colleagues at the institute for numerous discussions, Inge Zimmermann for patient
sectioning, and Silke Hein for help during the final\r\nstages of this work. M.
B. was supported by a Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Rolf
full_name: Karlstrom, Rolf
last_name: Karlstrom
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Alexander
full_name: Picker, Alexander
last_name: Picker
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of
the midline and general body shape during zebrafish embryogenesis. Development.
1996;123(1):129-142. doi:10.1242/dev.123.1.129
apa: Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle,
D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline
and general body shape during zebrafish embryogenesis. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.129
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri,
Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development
of the Midline and General Body Shape during Zebrafish Embryogenesis.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.129
.
ieee: M. Brand et al., “Mutations affecting development of the midline and
general body shape during zebrafish embryogenesis,” Development, vol. 123,
no. 1. Company of Biologists, pp. 129–142, 1996.
ista: Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker
A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations
affecting development of the midline and general body shape during zebrafish embryogenesis.
Development. 123(1), 129–142.
mla: Brand, Michael, et al. “Mutations Affecting Development of the Midline and
General Body Shape during Zebrafish Embryogenesis.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 129–42, doi:10.1242/dev.123.1.129 .
short: M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle,
A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter,
M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard,
Development 123 (1996) 129–142.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T12:55:13Z
day: '01'
doi: '10.1242/dev.123.1.129 '
extern: '1'
external_id:
pmid:
- '9007235 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and
month: '12'
oa: 1
oa_version: Published Version
page: 129 - 142
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1900'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the midline and general body shape during
zebrafish embryogenesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4219'
abstract:
- lang: eng
text: 'Mutations in two genes affect the formation of the boundary between midbrain
and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos
lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric
duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that
the MHB region and the dorsal and ventral midbrain are absent or abnormal, but
that the rostral hindbrain is unaffected with the exception of the cerebellum,
Using markers that are expressed during its formation (eng, wnt1 and pax-b), we
find that the MHB region is already misspecified in noi mutant embryos during
late gastrulation. The tectum is initially present and later degenerates, The
defect in ace mutant embryos is more restricted: MHB and cerebellum are absent,
but a tectum is formed, Molecular organisation of the tectum and tegmentum is
disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained,
We propose that noi and ace are required for development of the MHB region and
of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB
region, Presence of pax-b RNA, and absence of pax-b protein, together with the
observation of genetic linkage and the occurrence of a point mutation, show that
noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue
of the Drosophila gene paired, which is involved in a pathway of cellular interactions
at the posterior compartment boundary in Drosophila, Our results confirm and extend
a previous report, and show that at least one member of this conserved signalling
pathway is required for formation of the boundary between midbrain and hindbrain
in the zebrafish.'
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir
Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder,
Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B
would like to thank his colleagues for numerous discussions, and Francisco Pelegri,
Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also
to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression,
and especially to Corinne Houart, for her lovely in situ protocol and many discussions.
Silke Hein helped greatly in final stages of this work. M.B. was supported by a
Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Klaus
full_name: Lun, Klaus
last_name: Lun
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
1996;123(1):179-190. doi:10.1242/dev.123.1.179
apa: Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.179
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle,
Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish
Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.”
Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.179 .
ieee: M. Brand et al., “Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain,” Development, vol. 123,
no. 1. Company of Biologists, pp. 179–190, 1996.
ista: Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato
M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.
mla: Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation
of the Boundary between Midbrain and Hindbrain.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 179–90, doi:10.1242/dev.123.1.179 .
short: M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki,
M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal,
F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T11:45:04Z
day: '01'
doi: '10.1242/dev.123.1.179 '
extern: '1'
external_id:
pmid:
- '9007239 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the
month: '12'
oa: 1
oa_version: Published Version
page: 179 - 190
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations in zebrafish genes affecting the formation of the boundary between
midbrain and hindbrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4222'
abstract:
- lang: eng
text: Somitogenesis is the basis of segmentation of the mesoderm in the trunk and
tail of vertebrate embryos, Two groups of mutants with defects in this patterning
process have been isolated in our screen for zygotic mutations affecting the embryonic
development of the zebrafish (Danio rerio), In mutants of the first group, boundaries
between individual somites are invisible early on, although the paraxial mesoderm
is present, Later, irregular boundaries between somites are present, Mutations
infused somites (fss) and beamter (bea) affect all somites, whereas mutations
in deadly seven (des), after eight (aei) and white tail (wit) only affect the
more posterior somites, Mutants of all genes but wit are homozygous viable and
fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest
that anteroposterior patterning within individual somites is abnormal, In the
second group of mutants, formation of the horizontal myoseptum, which separates
the dorsal and ventral part of the myotome, is reduced, Six genes have been defined
in this group (you-type genes), yea-too mutants show the most severe phenotype;
in these the adaxial cells, muscle pioneers and the primary motoneurons are affected,
in addition to the horizontal myoseptum. The horizontal myoseptum is also missing
in mutants that lack a notochord. The similarity of the somite phenotype in mutants
lacking the notochord and in the you-type mutants suggests that the genes mutated
in these two groups are involved in a signaling pathway from the notochord, important
for patterning of the somites.
acknowledgement: We would like to thank P. Ingham and T. Whitfield for valuable comments
on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J.
Eisen and R. BreMiller for the znp-1 antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 1996;123(1):153-164.
doi:10.1242/dev.123.1.153
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.153
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting
Somite Formation and Patterning in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.153.
ieee: F. Van Eeden et al., “Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 153–164, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.
mla: Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 153–64, doi:10.1242/dev.123.1.153.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 153–164.
date_created: 2018-12-11T12:07:41Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T09:29:56Z
day: '01'
doi: 10.1242/dev.123.1.153
extern: '1'
external_id:
pmid:
- '9007237 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and
month: '12'
oa: 1
oa_version: Published Version
page: 153 - 164
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1895'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting somite formation and patterning in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4220'
abstract:
- lang: eng
text: In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during
embryogenesis. At larval stages the caudal fin fold is replaced by four different
fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins
are formed, We have identified a total of 118 mutations affecting larval fin formation,
Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal
and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly
normal complement of adult fins, Mutations in nine genes result in an increased
or reduced size of the pectoral fins, Interestingly, in mutants of one of these
genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium
fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme
of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations
in five other genes affect adult fin but not larval fin development, Two mutants,
longfin (lof) and another longfin (alf) have generally longer fins. Stein und
bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda
(wan) mutants affect all adult fins, Finally, mutations in four genes causing
defects in embryonic skin formation will be briefly reported.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation
in the zebrafish, Danio rerio. Development. 1996;123(1):255-262. doi:10.1242/dev.123.1.255
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.255
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis
of Fin Formation in the Zebrafish, Danio Rerio.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.255
.
ieee: F. Van Eeden et al., “Genetic analysis of fin formation in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
255–262, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. 123(1), 255–262.
mla: Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 255–62, doi:10.1242/dev.123.1.255
.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T10:01:17Z
day: '01'
doi: '10.1242/dev.123.1.255 '
extern: '1'
external_id:
pmid:
- '9007245 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish
month: '12'
oa: 1
oa_version: Published Version
page: 255 - 262
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic analysis of fin formation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4294'
abstract:
- lang: eng
text: 'Any sample of genes traces back to a single common ancestor. Each gene also
has other properties: its sequence, its geographic location and the phenotype
and fitness of the organism that carries it. With sexual reproduction, different
genes have different genealogies, which gives us much more information, but also
greatly complicates population genetic analysis. We review the close relation
between the distribution of genealogies and the classic theory of identity by
descent in spatially structured populations, and develop a simple diffusion approximation
to the distribution of coalescence times in a homogeneous two-dimensional habitat.
This shows that when neighbourhood size is large (as in most populations) only
a small fraction of pairs of genes are closely related, and only this fraction
gives information about current rates of gene flow. The increase of spatial dispersion
with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy
depends on the long-term history of the population; we discuss ways of inferring
this history from the concordance between genealogies across loci.'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Ian
full_name: Wilson, Ian
last_name: Wilson
citation:
ama: 'Barton NH, Wilson I. Genealogies and geography. In: New Uses for New Phylogenies.
Oxford University Press; 1996:23-56. doi:10.1098/rstb.1995.0090'
apa: Barton, N. H., & Wilson, I. (1996). Genealogies and geography. In New
uses for new phylogenies (pp. 23–56). Oxford University Press. https://doi.org/10.1098/rstb.1995.0090
chicago: Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In New
Uses for New Phylogenies, 23–56. Oxford University Press, 1996. https://doi.org/10.1098/rstb.1995.0090.
ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” in New uses for
new phylogenies, Oxford University Press, 1996, pp. 23–56.
ista: 'Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new
phylogenies. , 23–56.'
mla: Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” New Uses
for New Phylogenies, Oxford University Press, 1996, pp. 23–56, doi:10.1098/rstb.1995.0090.
short: N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University
Press, 1996, pp. 23–56.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-04T08:59:18Z
day: '01'
doi: 10.1098/rstb.1995.0090
extern: '1'
external_id:
pmid:
- '8748019'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 56
pmid: 1
publication: New uses for new phylogenies
publication_identifier:
isbn:
- 978-0198549840
publication_status: published
publisher: Oxford University Press
publist_id: '1783'
quality_controlled: '1'
status: public
title: Genealogies and geography
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4295'
abstract:
- lang: eng
text: Genetic studies are beginning to provide insights into the evolutionary processes
that reduce the fitness of hybrids between recently diverged species. However,
the deleterious gene interactions responsible for this fitness reduction are still
poorly understood.
acknowledgement: Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael
Turelli for their comments on this note, and to the BBSRC and NERC for financial
support.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Speciation: more than the sum of its parts. In: Current Biology.
Vol 6. Cell Press; 1996:1244-1246. doi:10.1016/S0960-9822(02)70707-0'
apa: 'Barton, N. H. (1996). Speciation: more than the sum of its parts. In Current
Biology (Vol. 6, pp. 1244–1246). Cell Press. https://doi.org/10.1016/S0960-9822(02)70707-0'
chicago: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In Current
Biology, 6:1244–46. Cell Press, 1996. https://doi.org/10.1016/S0960-9822(02)70707-0.'
ieee: 'N. H. Barton, “Speciation: more than the sum of its parts,” in Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–1246.'
ista: 'Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology.
vol. 6, 1244–1246.'
mla: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–46, doi:10.1016/S0960-9822(02)70707-0.'
short: N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.
date_created: 2018-12-11T12:08:06Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2022-07-07T09:28:28Z
day: '01'
doi: 10.1016/S0960-9822(02)70707-0
extern: '1'
external_id:
pmid:
- '8939554'
intvolume: ' 6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub
month: '10'
oa: 1
oa_version: Published Version
page: 1244 - 1246
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Speciation: more than the sum of its parts'
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1996'
...
---
_id: '4419'
abstract:
- lang: eng
text: A {\em hybrid automaton\/} consists of a finite automaton interacting with
a dynamical system. Hybrid automata are used to model embedded controllers and
other systems that consist of interacting discrete and continuous components.
A hybrid automaton is {\em rectangular\/} if each of its continuous variables~x
satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where
a and~b are rational constants. Rectangular hybrid automata are particularly useful
for the analysis of communication protocols in which local clocks have bounded
drift, and for the conservative approximation of systems with more complex continuous
behavior. We examine several verification problems on the class of rectangular
hybrid automata, including reachability, temporal logic model checking, and controller
synthesis. Both dense-time and discrete-time models are considered. We identify
subclasses of rectangular hybrid automata for which these problems are decidable
and give complexity analyses. An investigation of the structural properties of
rectangular hybrid automata is undertaken. One method for proving the decidability
of verification problems on infinite-state systems is to find finite quotient
systems on which analysis can proceed. Three state-space equivalence relations
with strong connections to temporal logic are bisimilarity, similarity, and language
equivalence. We characterize the quotient spaces of rectangular hybrid automata
with respect to these equivalence relations.
article_processing_charge: No
author:
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: Kopke P. The Theory of Rectangular Hybrid Automata. 1996.
apa: Kopke, P. (1996). The Theory of Rectangular Hybrid Automata. Cornell
University.
chicago: Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University,
1996.
ieee: P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University,
1996.
ista: Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.
mla: Kopke, Peter. The Theory of Rectangular Hybrid Automata. Cornell University,
1996.
short: P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University,
1996.
date_created: 2018-12-11T12:08:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T15:11:24Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication_status: published
publisher: Cornell University
publist_id: '312'
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: The Theory of Rectangular Hybrid Automata
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...